Abstract:
Compounds having the formula:                            
     wherein R 1 -R 5 , X and G are described herein and which are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

Description:
This application is a divisional application of U.S. Ser. No. 09/447,006 filed Nov. 22, 1999 now U.S. Pat. No. 5,197,803 and U.S. Ser. No. 09/444,782, filed Nov. 22, 1999 now U.S. Pat. No. 6,166,028 which claims benefit of prior U.S. Provisional application Nos. 60/150,698, 60/155,240, 60/155,192, 60/150,692, 60/228,805, 60/228,808 and 60/228,809 filed Dec. 9, 1998. These applications are herein incorporated by reference in their entireties. 
    
    
     BACKGROUND OF THE INVENTION 
     Eight viruses have been identified which are members of the family Herpesviridae (reviewed in Roizman, B. 1996. Herpesviridae, p. 2221-2230. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.). Each member of this family is characterized by an enveloped virus containing proteinaceous tegument and nucleocapsid, the latter of which houses the viruses&#39; relatively large double-stranded DNA genome (i.e. approximately 80-250 kilobases). Members of the human alphaherpesvirus subfamily are neurotropic and include herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and varicella-zoster virus (VZV). The human betaherpesviruses are cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7). The gammaherpesviruses are lymphotropic and include Epstein-Barr virus (EBV) and Kaposi&#39;s herpesvirus (HHV-8). Each of these herpesviruses is causally-related to human disease, including herpes labialis and herpes genitalis (HSV-1 and HSV-2 [Whitley, R. J. 1996. Herpes Simplex Viruses, p. 2297-2342. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]); chicken pox and shingles (VZV [Arvin, A. 1996. Varicella-Zoster Virus, p. 2547-2585. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]); infectious mononucleosis (EBV [Rickinson, A. B. and Kieff, E. 1996. Epstein-Barr Virus, p. 2397-2446. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]); pneumonia and retinitis (HCMV [(Britt, W. J., and Alford, C. A. 1996. Cytomegalovirus, p. 2493-2523. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]); exanthem subitum (HHV-6 [(Pellet, P. E, and Black, J. B. 1996. Human Herpesvirus 6, p. 2587-2608. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]and HHV-7 [Frenkel, N., and Roffman, E. 1996. Human Herpesvirus 7, p. 2609-2622. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.]); and Kaposi&#39;s sarcoma (HHV-8 [Neipel, F., Albrecht, J.C., and Fleckenstein, B. 1997. Cell-homologous genes in the Kaposi&#39;s sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J. Virol. 71:4187-92, 1997]). HCMV is considered in more detail below. Following the primary infection, herpesviruses establish latency within the infected individual and remain there for the remainder of his/her life. Periodic reactivation of latent virus is clinically relevant. In the case of HSV, reactivated virus can be transmitted to infants during birth, causing either skin or eye infection, central nervous system infection, or disseminated infection (i.e. multiple organs or systems). Shingles is the clinical manifestation of VZV reactivation. Treatment of HSV and VZV is generally with antiviral drugs such as acyclovir (Glaxo Wellcome), ganciclovir (Roche) and foscarnet (Asta) which target viral encoded DNA polymerase. 
     HCMV is a ubiquitous opportunistic pathogen infecting 50-90% of the adult population (Britt, W. J., and Alford, C. A. 1996. Cytomegalovirus, p. 2493-2523. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.). Primary infection with HCMV is usually asymptomatic, although heterophile negative mononucleosis has been observed. The virus is horizontally transmitted by sexual contact, breast milk, and saliva. Intrauterine transmission of HCMV from the pregnant mother to the fetus occurs and is often the cause of serious clinical consequences. HCMV remains in a latent state within the infected person for the remainder of his/her life. Cell-mediated immunity plays a central role in controlling reactivation from latency. Impaired cellular immunity leads to reactivation of latent HCMV in seropositive persons. 
     HCMV disease is associated with deficient or immature cellular immunity. There are 3 major categories of persons with HCMV disease (reviewed by Britt and Alford, 1996). (1) In immunocompromised (AIDS) patients, HCMV is one of the two most common pathogens causing clinical disease (the other is Pneumocystis). The most common manifestation of HCMV in AIDS is retinitis, although infection of other organs including the adrenal glands, lungs. GI tract, and central nervous system are also reported frequently. 90% of AIDs patients have active HCMV infection; 25-40% (˜85,000 patients in the United States) have life- or sight-threatening HCMV disease. HCMV is the cause of death in 10% of persons with AIDs. (2) Due to immune system suppression to reduce the risk of graft rejection, HCMV reactivation or reinfection is common amongst kidney, liver, heart, and allogeneic bone marrow transplant patients. Pneumonia is the most common HCMV disease in these patients, occurring in up to 70% of these transplant patients. (3) Congenital infection due to HCMV occurs in 1% of all births, about 40K per year. Up to 25% of these infants are symptomatic for HCMV disease between ages 0-3 years. HCMV disease is progressive, causing mental retardation and neurological abnormalities, in children. Recent studies suggest that treatment with anti-HCMV drugs may reduce morbidity in these children. 
     Several antiviral drugs are currently being marketed (Bron, D., R. Snoeck, and L. Lagneaux. 1996. New insights into the pathogenesis and treatment of cytomegalovirus. Exp. Opin. Invest. Drugs 5:337-344; Crumpacker, C. 1996. Ganciclovir. New Eng. J. Med. 335:721-729; Sachs, S., and F. Alrabiah. 1996. Novel herpes treatments: a review. Exp. Opin. Invest. Drugs 5:169-183). These include: ganciclovir (Roche), a nucleoside analog with hemopoietic cell toxicity; foscarnet (Astra), a pyrophosphate analog with nephrotoxicity; and cidofovir, Gilead), a nucleoside phosphonate with acute nephrotoxicity. Each of these drugs target the viral-encoded DNA polymerase, are typically administered intravenously due to their low bioavailability, and, as noted above, are the source of significant toxicity. Ganciclovir-resistant mutants which arise clinically are often cross-resistant with cidofovir. Hence, there is a need for safer (i.e. less toxic), orally bioavailable anti-viral drugs which are directed against novel viral targets. 
     Phenyl thioureas are disclosed for use in a variety of pharmaceutical applications. Armistead, et al., WO 97/40028, teaches phenyl ureas and thioureas as inhibitors of the inosine monophosphate dehydrogenase (IMPDH) enzyme which is taught to play a role in viral replication diseases such herpes. 
     Widdowson, et al., WO 96/25157, teaches phenyl urea and thiourea compounds of the below formula for treating diseases mediated by the chemokine, interleukin-8.                           
     Morin, Jr., et al., U.S. Pat. No. 5,593,993 teaches certain phenyl thiourea compounds for treatment of AIDs and the inhibition of the replication of HIV and related viruses. 
     Therefore, it is an object of this invention to provide compounds, and pharmaceutically acceptable salts thereof, to inhibit and/or treat diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus. 
     DESCRIPTION OF THE INVENTION 
     In accordance with the present invention are provided compounds having the formula:                           
     wherein 
     R 1 -R 5  are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, —CN, —NO 2 , —CO 2 R 6 , —COR 6 , —OR 6 , —SR 6 , —SOR 6 , —SO 2 R 6 , —CONR 7 R 8 , —NR 6 N(R 7 R 8 ), —N(R 7 R 8 ) or W—Y—(CH 2 ) n —Z provided that at least one of R 1 -R 5  is not hydrogen; or R 2  and R 3  or R 3  and R 4 , taken together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; 
     R 6  and R 7  are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; 
     R 8  is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or 
     R 7  and R 8 , taken together may form a 3 to 7 membered heterocycloalkyl; 
     W is O, NR 6 , or is absent; 
     Y is —(CO)—or —(CO 2 )—, or is absent; 
     Z is alkyl of 1 to 4 carbon atoms, —CN, —CO 2 R 6 , COR 6 , —CONR 7 R 8 , —OCOR 6 , —NR 6 COR 7 , —OCONR 6 , —OR 6 , —SR 6 , —SOR 6 , —SO 2 R 6 , SR 6 N(R 7 R 8 ), —N(R 7 R 8 ) or phenyl; 
     G is monocyclic heteroaryl; 
     X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; 
     J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and 
     n is an integer from 1 to 6, or pharmaceutical salts thereof. 
     In some preferred embodiments of the present invention, R 1 -R 5  are independently, hydrogen alkyl of 1 to 6 carbon atoms, halogen, perhaloalkyl of 1 to 6 carbon atoms, OR 6  or N(R 7 R 8 ). Preferably, 1 to 3 of R 1 -R 5  is not hydrogen. Most preferably, 2 of R 1 -R 5  is not hydrogen. In preferred compounds of the present invention R 3  and R 5 , or R 4  and R 5  are preferably, independently, halogen or CF 3 . 
     In some embodiments of the present invention G is monocyclic heteroaryl, preferably thiazolyl, thiadiazolyl, oxazolyl or furyl. G is preferably not substituted. 
     In some embodiments of the present invention X is a bond, CH(J) or C 1 -C 4  alkyl. Preferably, when X is C 1 -C 4  alkyl, said alkyl is straight chain alkyl. When X is CH(J), J is preferably methyl. 
     Preferred compounds of the present invention are the following compounds which include pharmaceutical salts thereof. 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-piperidin-1-yl-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-dimethylamino-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-dimethylamino-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     Thiazole-4-carboxylic acid {4-[3-(4-tert-butyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     Thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-ethyl]-thioureido}-pheyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-tert-butyl-benzyl)-thioureido]-phenyl}-amide, 
     Thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2,4-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-iodo-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2,4-dichloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     Thiazole-4-carboxylic acid {4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-iodo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     Furan-2-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(2-methyl-butyl)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-isobutyl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-dimethylamino-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     Thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide, 
     Thiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-iodo-phenyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid [4-(3-benzo[1,3]dioxol-5-ylmethyl-thioureido)-phenyl]-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,3-diphenyl-propyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-fluoro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-pyrrolidin-1-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(butyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dimethyl-benzyl)-thioureido]-phenyl}-amide, 
     Thiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-chloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-ethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide. 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [ 1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-difluoro-benzyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid {4-[3-(3,5-dichloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-p-tolyl-ethyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-phenyl-butyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-phenylsulfanyl-ethyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-iodo-benzyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid (4-{3-[2-(3-bromo-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide, 
     Oxazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl)}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-difluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-difluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-iodo-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-amino-5-chloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(isobutyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-phenyl-propyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid{4-[3-(3-chloro-4-fluoro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid{4-[3-(3,4,5-trichloro-phenyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-morpholin-4-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-iodo-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo-4-trifluoromethoxy-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-dimethylamino-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[4-(4-methyl-piperazin-1-yl)-3-trifluoromethyl-benzyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-difluoro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-3-chloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-phenoxy-ethyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-methyl-phenyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid {4-[3-(3-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-nitro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-piperidin-1-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     Oxazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid {4-[3-(3,4,5-trichloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-benzo[1,3]dioxol-5-ylmethyl-thioureido)-phenyl]-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-phenethyl-thioureido)-phenyl]-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-chloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(1H-pyrazol-3-yl)-phenyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(2-piperidin-1-yl-acetylamino)-phenyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-amide, 
     Furan-2-carboxylic acid [4-(3-benzyl-thioureido)-phenyl]-amide, 
     Furan-2-carboxylic acid (4-{3-[2-(3,5-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide, 
     Furan-2-carboxylic acid (4-{3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-4-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     Oxazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-chloro-benzyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-benzyl)-thioureido]-phenyl}-amide, 
     Furan-2-carboxylic acid {4-[3-(4-bromo-3-chloro-phenyl)-thioureido]-phenyl}-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1S)-1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1R)-1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1S)-1-(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1R)-1-(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     N-[4-[[[[1-(4-Cyanophenyl)ethyl]amino]thioxomethyl]amino]phenyl]-1,2,3-thiadiazole-4-carboxamide, 
     Thiazole-4-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide, 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-(1S)-[1-(3,5-bis-trifluoromethyl-phenyl)-ethy]-thioueido}-phenyl)-amide, 
     N-(4-{[({1-[4-fluoro-3-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,2,3,-thiadiazole-4-carboxamide, 
     N-(4-{[({1-[4-chloro-3-thiadiazole-4-carboxamide, 
     N-(4-{[({(1S)-1-[3,5-thiazole-4-carboxamide, 
     N-(4-{[({1-[3-fluoro-5-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-(4-({[({1-[2-fluoro-5-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-(4-{[(1-[2,4-bis(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-}4-[({[1-(2,4-dimethylphenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(2,4-dichlorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3-methylphenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[4-fluoro-3-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(2-chloro-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[{([1-(3,4-difluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(4-bromo-2-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(2-bromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3-bromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[2-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(2,4-difluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3,4-dichlorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(4-chloro-2-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[4-fluoro-2-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(4-chloro-3-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(2-bromo-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3,4-dibromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-{4-[({[1-(3-chloro-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, 
     N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]propyl  56  amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide, 
     N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]butyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide, 
     N-(4-{[(1-[3,5-bis(trifluoromethyl)phenyl]pentyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide, 
     N-{4-[({[[3,5-bis(trifluoromethyl)phenyl](phenyl)methyl]amino}carbothioyl)amino]phenyl}-1,2,3-thiadiazole-4-carboxamide, 
     N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide, 
     N-{4-[({[3,5-bis(trifluoromethyl)benzyl]amino}carbothioyl)amino]phenyl}-1H-imidazole-4-carboxamide, 
     N-{4-[({[1-(4-fluorophenyl)ethy]amino}carbothioyl)amino]phenyl}-1H-imidazole-4-carboxamide, 
     N-{4-[({[3,5-bis(trifluoromethyl)benzyl]amino}carbothioyl)amino]phenyl)-1-methyl-1H-imidazole-4-carboxamide, 
     N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]propyl)amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide; and pharmaceutical salts thereof. 
     Unless otherwise defined, the terms used herein have the following meanings. 
     Alkyl as used herein refers to straight or branched chain lower alkyl of 1 to 6 carbon atoms. Exemplary alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl and hexyl. 
     Alkenyl as used herein refers to straight or branched chain lower alkyl of 2 to 6 carbon atoms containing at least one carbon-carbon double bond. Alkenyl includes vinyl groups. 
     Alkynyl as used herein refers to straight or branched chain lower alkyl of 2 to 6 carbon atoms containing at least one carbon-carbon triple bond. 
     Alkyl, alkenyl and alkynyl groups of the present invention may be substituted or unsubstituted. 
     Cycloalkyl refers to a saturated mono or bicyclic ring system of 3 to 10 carbon atoms. Exemplary cycloalkyl groups include cyclopentyl, cyclohexyl and cycloheptyl. Cycloalkyl groups of the present invention may be substituted or unsubstituted. 
     Heterocycloalkyl refers to a saturated mono or bicyclic ring system of 3 to 10 members having 1 to 3 heteroatoms selected from N, S and O, including, but not limited to aziridinyl, azetidinyl, imidazolidinyl, morpholinyl, thiomorpholinyl, piperazinyl, pyrazolidinyl, piperidinyl, and pyrrolidinyl. Heterocycloalkyl groups of the present invention may be substituted or unsubstituted. 
     Aryl, as used herein refers to an aromatic mono or bicyclic ring of 6 to 10 carbon atoms. Exemplary aryl groups include phenyl, naphthyl, and biphenyl. Aryl groups of the present invention may be substituted or unsubstituted. 
     Heteroaryl as used herein refers to an aromatic mono or bicyclic ring of 5 to 10 members having 1 to 3 heteroatoms selected from N, S or O including, but not limited to thiazolyl, thiadiazolyl, oxazolyl, furyl, indolyl, benzothiazolyl, benzotriazolyl, benzodioxyl, indazolyl, and benzofuryl. Preferred heteroaryls include quinolyl, isoquinolyl, napthalenyl, benzofuranyl, benzothienyl, indolyl, pyridyl, pyrazinyl, thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, pyrazolyl, triazolyl, thiadiazolyl, and imidazolyl. Heteroaryl groups of the present invention may be substituted or unsubstituted. 
     Perhaloalkyl refers to an alkyl group of 1 to 6 carbon atoms in which three or more hydrogens are substituted with halogen. 
     Phenyl as used herein refers to a 6 membered aromatic ring. 
     Halogen, as used herein refers to chlorine, bromine, iodine and fluorine. 
     Unless otherwise limited, substitutents are unsubstituted and may include alkyl of 1 to 6 carbon atoms, cycloalkyl of 1 to 6 carbon atoms, heterocycloalkyl of 1 to 6 members, perhaloalkyl of 1 to 6 carbon atoms, amino, azido, hydroxy, alkylamino, dialkylamino, aryl or heteroaryl. 
     Carbon number refers to the number of carbons in the carbon backbone and does not include carbon atoms occurring in substituents such as an alkyl or alkoxy substituents. 
     Where terms are used in combination, the definition for each individual part of the combination applies unless defined otherwise. For instance, alkylcycloalkyl is an alkyl-cycloalkyl group in which alkyl and cycloalkyl are as previously described. 
     Pharmaceutically acceptable salts are the acid addition salts which can be formed from a compound of the above general formula and a pharmaceutically acceptable acid such as phosphoric, sulfuric, hydrochloric, hydrobromic, citric, maleic, succinic, fumaric, acetic, lactic, nitric, sulfonic, p-toluene sulfonic, methane sulfonic acid, and the like. 
     The compounds of this invention contain a chiral center, providing for various seteroisomeric forms of the compounds such as racemic mixtures as well as the individual optical isomers. In some preferred embodiments of the present invention the compounds of the present invention are substantially pure optical isomers. By substantially pure optical isomer is meant the composition contains greater than 75% of the desired isomer and may include no more than 25% of the undesired isomer. In more preferred embodiments the pure optical isomer is greater than 90% of the desired isomer. The individual isomers can be prepared directly or by asymmetric or stereospecific synthesis or by conventional separation of optical isomers from the racemic mixture. 
     Compounds of the present invention may be prepared by those skilled in the art of organic synthesis employing methods described below which utilize readily available reagents and starting materials unless otherwise described. Compounds of the present invention are thus prepared in accordance with the following schemes. 
     The novel compounds of the present invention are prepared according to the following reaction schemes. 
     Referring to Methods 31 and 34, reacting appropriately substituted amines 2, wherein the substitutents R 1 -R 5 , and X are described as above, with appropriately substituted isothiocyanates 3, wherein the substituent G is described above, either neat or in an appropriate solvent such as tetrahydrofuran, acetonitrile, ethyl acetate, dichloromethane, or N,N-dimethylformamide affords the desired thioureas 1. Similarly, reaction of appropriately substituted isothiocyanates 4, wherein the substitutents R 1 -R 5 , and X are described as above with appropriately substituted anilines 5, wherein the substituent G is described above, in a convenient solvent such as those listed above affords the desired thioureas 1.                           
     Alternatively, appropriately substituted thioureas 1 can be prepared as described by Methods 32 and 33 by reacting anilines 2 and 5, wherein R 1 -R 5 , and G are described as above, in the presence of either one molar equivalent of 1,1′-thiocarbonyldiimidazole or 1,1′-carbonyldiimidazole in an appropriate solvent such as dichloromethane and tetrahydrofuran or mixtures thereof or one molar equivalent of 1,1′-thiocarbonyl-di-(1,2,4)-triazole or 1,1′-carbonyl-di-(1,2,4)-triazole in an appropriate solvent such as dichloromethane and tetrahydrofuran or mixtures thereof at room temperature.                           
     In certain instances, subsequent chemical modification of the final thioureas 1 was required. These methods, Methods 35-39, are summarized below.                         
                           
     Thioureas 1 wherein at least one substituent of R 1 -R 5  is 1-hydroxyethoxy or carboxy-methoxy, G is defined as above and X equals a bond, may be prepared from the corresponding alkyl esters by alkaline hydrolysis with aqueous sodium or potassium hydroxide in a suitable solvent such as methanol, tetrahydrofuran or mixtures thereof at room temperature in accordance with Methods 35 and 36. 
     Thioureas 1 wherein at least one substituent of R 1 -R 5  is 1-acyloxyethoxy or methansulfonoxyethoxy, G is defined as above and X equals a bond, may be prepared from the corresponding 1-hydroxyethoxy derivative by acylation with appropriate acylating agents such as benzoic acid chloride or methanesulfonic acid chloride in the presence of a suitable tertiary amine base such as triethylamine or diisopropylethylamine in a suitable solvent such as dichloromethane or the like at room temperature in accordance with Methods 37 and 38. 
     Thioureas 1 wherein at least one substituent of R 1 -R 5  is 1-aminoethoxy, G is defined as above and X equals a bond, may be prepared from the corresponding 1-methanesulfonoxy-ethoxy derivative by reaction with an appropriate secondary amine such as dimethylamine in a suitable solvent mixture such as tetrahydrofuran and water or the like at room temperature in accordance with Method 39. 
     Thioureas 1 wherein at least one substituent of R 1 -R 5  is 1-aminoalkyl, G is defined as above and X equals a bond, may be prepared from the corresponding 1-azidoalkyl derivative by reaction with stannous chloride in a suitable solvent such as methanol, ethanol or the like at room temperature in accordance with Method 40. 
     The intermediate isothiocyanates 3 and 4 shown above in Methods 31 and 34 are prepared in accordance with Method 41 (below) essentially according to the procedures of Staab, H. A. and Walther, G.  Justus Liebigs Ann. Chem.  657, 104 (1962)) by reacting appropriately substituted amines 5 or 2, respectively, wherein R 1 -R 5  and G are described above and X is defined above, with one molar equivalent of 1,1′-thiocarbonyldiimidazole in an appropriate solvent such as dichloromethane and tetrahydrofuran or mixtures thereof.                           
     The intermediates 2 and 5 may be prepared according to the following protocols: 
     According to,Methods 1A-1G, amines 2, wherein R 1 -R 5  are defined above and X is defined above, amines 5 may be prepared by reduction of the appropriately substituted nitrobenzenes according to a variety of procedures known to those skilled in the art and described in R. J. Lindsay,  Comprehensive Organic Chemistry  (ed. Sutherland), Volume 2, Chapter 6.3.1, Aromatic Amines, 1979. Such procedures include the reduction of nitrobenzenes to form anilines upon exposure to: 
     a) iron powder and a strong acid, such as hydrochloric acid (Methods 1A) either neat or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the refluxing temperature of the solvent, or; 
     b) iron powder and glacial acetic acid (Method 1B), either neat or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the refluxing temperature of the solvent, or; 
     c) iron powder and aqueous ammonium chloride (Method 1C), either neat or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the refluxing temperature of the solvent, or; 
     d) tin and a strong mineral acid, such as hydrochloric acid (Method 1D), either neat or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the refluxing temperature of the solvent, or; 
     e) when R 1 -R 5  are selected from Cl, Br, I, —(OSO 2 )—CF 3 , or —(OSO 2 )-1-(4-methylpheny), by catalytic reduction such as with hydrogen and palladium on carbon (Method 1E) in an appropriate solvent such as methanol, ethanol, or ethyl acetate, under one or more atmospheres of pressure or; 
     f) when R 1 -R 5  and R 9 -R  12  are selected from Cl, Br, I, —(OSO 2 )—CF 3 , or —(OSO 2 )-1-(4-methylphenyl), by catalytic reduction such as with cyclohexene and palladium on carbon (Method 1F) in an appropriate solvent such as methanol or ethanol, at temperatures ranging from room temperature to the refluxing temperature of the solvent, or; 
     g) aqueous sodium hydrosulfite in alcohol solvent at temperatures ranging from room temperature to the refluxing temperature of the solvent (Method 1G). 
     Alternatively, according to Methods 3A-3C, amines 2, wherein R 1 -R 5  are defined above and X is defined above and anilines 5, above may be prepared by the cleavage of the aniline nitrogen-carbon bond of amide and carbamate derivatives of these anilines according to a variety of procedures known to those skilled in the art and described in Greene,  Protective Groups in Organic Synthesis  volume 2, Chapter 7, 1991, and references therein. Such procedures include: 
     a) the exposure of appropriately substituted arylamino-tert-butyl-carbamates to a strong acid such as trifluoroacetic acid (Method 3A)either neat or in an appropriate solvent such as dichloromethane at temperatures between 0° C. and room temperature, or; 
     b) the exposure of appropriately substituted arylamino-(2-trimethylsilylethyl)-carbamates to a fluoride ion source such as tetrabutylammonium fluoride or potassium fluoride (Method 3B) in aqueous acetonitrile or tetrahydrofuran or mixtures thereof at temperatures ranging from room temperature to the reflux temperature of the solvent, or; 
     c) the exposure of appropriately substituted arylamino-trifluoroacetamides to a strong base such as sodium or potassium hydroxide or sodium or potassium carbonate in an alcohol solvent such as methanol or ethanol (Method 3C) at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Alternatively, according to Method 11, amines 2, wherein R 1 -R 5  are defined above, and X is defined above at least one substituent of R 1 -R 5  is defined as vinyl, may be prepared by the palladium catalyzed coupling of a vinyl trialkyltin reagent, such as tributylvinyltin, with an appropriately substituted bromo- or iodo-aniline, for example 3-chloro-4-iodo-aniline, employing a palladium catalyst, such as tris(dibenzylidineacetone)-bipalladium, and a ligand, such as triphenylarsine, in a suitable solvent such as tetrahydrofuran or N-methylpyrrolidinone, at temperatures ranging from room temperature to the reflux temperature of the solvent, essentially according to the procedures of V. Farina and G. P. Roth in  Advances in Metal - Organic Chemistry , Vol. 5, 1-53, 1996 and references therein. 
     Alternatively, according to Method 42, amines 2, wherein R 1 -R 5  are defined above and X is defined above and at least one substituent of R 2  or R 4  is defined as dialkylamino, may be prepared by the palladium catalyzed amination of an appropriately substituted 3- or 5-bromo- or iodo-aniline, for example 3-amino-5-bromobenzotrifluoride, by secondary amines under conditions which employ a palladium catalyst, such as bis(dibenzylidineacetone)palladium, and a ligand, such as tri-o-tolylphosphine, and at least two molar equivalents of a strong base, such as lithium bis-(trimethylsilyl)amide in a sealed tube, in a suitable solvent such as tetrahydrofuran or toluene, at temperatures ranging from room temperature to 100° C., essentially according to the procedures of J. F. Hartwig and J. Louie  Tetrahedron Letters  36 (21), 3609 (1995). 
     Alternatively, according to Method 43, amines 2, wherein R 1 -R 5  are defined above and X is defined above and at least one substituent of R 2  or R 4  is defined as alkyl, may be prepared by the palladium catalyzed alkylation of an appropriately substituted 3- or 5-bromo- or iodo-aniline, for example 3-amino-5-bromobenzotrifluoride by alkenes under conditions which employ a palladiumcatalyst such as [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) chloride-dichloromethane complex and in the presence of 9-borabicyclo[3.3.1]nonane and a suitable base such as aqueous sodium hydroxide in a suitable solvent such as tetrahydrofuran or the like at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     The acyl and carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C may be prepared by the derivatization of the corresponding amines as described in Methods 2A-2G according to a variety of procedures known to those skilled in the art and described in Greene,  Protective Groups in Organic Synthesis  volume 2, Chapter 7, 1991, and references therein. Such procedures include: 
     a) the reaction of an appropriately substituted amine with di-tert-butyl-dicarbonate (Method 2A) in the presence or absence of one or more molar equivalents of a tertiary amine such as triethylamine or N,N-diisopropylethylamine in a suitable solvent such as acetone, tetrahydrofuran, dimethylformamide, dichloromethane, and the like, at temperatures ranging from room temperature to the reflux temperature of the solvent to produce the corresponding arylamino-tert-butyl-carbamate, or; 
     b) the reaction of an appropriately substituted aniline with 1-[2-(trimethylsilyl)ethoxycarbonyl-oxy]benzotriazole (Method 2B) in the presence of a tertiary amine such as triethylamine or diisopropylethylamine in a suitable solvent such as dimethylformamide at room temperature to produce the corresponding arylamino-(2-trimethylsilylethyl)-carbamate, or; 
     c) the reaction of an appropriately substituted aniline with a carboxylic acid chloride or acid anhydride (Method 2C) either neat or in an appropriate solvent such as tetrahydrofuran, dimethylformamide, dichloromethane, pyridine and the like, in the presence of one or more molar equivalents of a tertiary amine base such as triethylamine or N,N-diisopropylethyl-amine to produce the corresponding arylaminoamide, or; 
     d) the reaction of an apptopriately substituted nitro aniline with a carboxylic acid chloride (Method 2D) in the absence of one or more molar equivalents of a tertiary amine base such as triethylamine or N,N-diisopropylethylamine either neat or in an appropriate solvent such as tetrahydrofuran, 1,4-dioxane and the like at temperatures ranging from room temperature to the reflux temperature of the solvent to produce the corresponding nitro arylaminoamide, or; 
     e) the reaction of an appropiately substituted aniline with a carboxylic acid (Method 2E) in the presence of a coupling agent such as benzotriazole-1-yloxy-tris-(dimethylamino)-phosphonium hexafluorophosphate, 2-(1H-benzotriazole-1-yloxy)-1,1,3,3-tetra-methyluronium hexafluorophosphate, dicyclohexyl carbodiimide and the like and in the presence of a tertiary amine such as triethylamine or diisopropylethylamine in a suitable solvent such as diichloromethane, dimethylformamide and the like, at room temperature to produce the corresponding arylaminoamide, or; 
     f) the reaction of an appropriately protected aniline such as an arylamino-tert-butyl-carbamate or the like in which at least one substituent of R 1 -R 12  is defined as —W—Y—(CH 2 ) n —Z wherein W, Y, and Z are defined as above, with a carboxylic acid anhydride (Method 2F) in the presence of a suitable base such as pyridine in an appropriate such as dichloromethane, dimethylformamide or the like at temperatures ranging from 0° C. to room temperature to produce the corresponding carboxylic acid ester, or; 
     g) the reaction of an appropriately substituted aniline in which a t least one substituent of R 1 -R 5  is defined as hydroxyl with di-tert-butyl-dicarbonate (Method 2G) in the absence of one or more molar equivalents of a tertiary amine such as triethylamine or N,N-diisopropylethylamine in a suitable solvent such as acetone, tetrahydrofuran, dimethylformamide, dichloromethane, and the like, at temperatures ranging from room temperature to the reflux temperature of the solvent to produce the corresponding arylamino-tert-butyl-carbamate. 
     Nitrobenzene intermediates that are ultimately converted to amines 2 and 5 by methods shown above in Methods 1A-1G may be prepared in accordance with Methods 4A, 4C, 4E-4F. 
     Referring to Methods 4A, 4C, and 4E-4H, the nitrobenzene intermediates which are ultimately converted into amines 2, R 2  and R 4  are defined above and R 1 , R 3 , and/or R 5  are defined as alkoxy, thioalkoxy, alkylsulfenyl, alkylsulfinyl, and dialkylamino may be prepared by the nucleophilic displacement of appropriately substituted 2-, 4-, and/or 6-fluoro-, chloro-, bromo-, iodo-, trifluoromethylsulfonyl-, or (4-methylphenyl)sulfonyl-substituted nitrobenzenes by methods which include the following: 
     a) reaction of alcohols with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4A) either neat or in an appropriate solvent such as tetrahydrofuran, dioxane, acetonitrile, N,N-dimethylformamide or dimethylsulfoxide in the presence or absence of one or more molar equivalents of a base such as sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride, potassium hydride, or the like, at temperatures ranging from room temperature to the reflux temperature of the solvent; 
     b) reactions of preformed sodium, lithium, or potassium phenoxides with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4H) either neat or in an appropriate solvent such as tetrahydrofuran, dioxane, acetonitrile, N,N-dimethylformamide or dimethylsulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; 
     c) reaction of ammonia, primary or secondary amines with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Methods 4C,F) either neat or in an appropriate solvent such as tetrahydrofuran, dioxane, acetonitrile, N,N-dimethyl-formamide or dimethylsulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent; 
     d) reaction of preformed sodium, lithium, or potassium salts of amines with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4G) in an appropriate solvent such as tetrahydrofuran at temperatures ranging from 0° C. to the reflux temperature of the solvent, or; 
     e) reaction of sodium sulfide with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles either neat or in an appropriate solvent such as tetrahydro-furan, dioxane, acetonitrile, N,N-dimethylformamide or dimethylsulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent, followed by the addition of an alkyl halide directly to the reaction mixture (Method 4E). 
     Alternatively, referring to Methods 5C and 6, the nitrobenzene intermediates which are ultimately converted into amines 2, wherein at least one substitutent R 1 -R 5  is defined as alkoxy may be prepared from the corresponding substituted hydroxy-nitrobenzenes by methods which include the following: 
     a) reaction of the hydroxy-nitrobenzene with an alkyl halide or dialkyl sulfonate ester (Method 5C) in the presence of a base, such as potassium carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, potassium hydride, or sodium hydride, in an appropriate solvent such as acetone, N,N-dimethylformamide, tetrahydrofuran or dimethylsulfoxide at temperatures ranging from room temperature to the reflux temperature of the solvent, or; 
     b) reaction of the hydroxy-nitrobenzene with an alkyl alcohol, triphenylphosphine, and a dialkylazadicarboxylate reagent (Method 6), such as diethylazodicarboxylate, in an anhydrous aprotic solvent such as diethyl ether or tetrahydrofuran at temperatures ranging from 0° C. to the reflux temperature of the solvent, essentially according to methods described in Mitsunobu, O, Synthesis 1981, 1 and references therein. 
     In addition, referring to Method 5A and 5E, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein at least one substituent R 1 -R 5  is defined as alkoxy may be prepared the corresponding substituted hydroxy arylamino-tert-butyl-carbamate by reaction with alkyl halides, trifluormethane-sulfonates, 4-methylbenzenesulfonates, dialkylsulfonate, ethylene carbonate and the like in the presence of a suitable base such as potassium carbonate in an appropriate solvent such as acetone, toluene, or N,N-dimethylformamide at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Alternatively, referring to Methods 7A-G, the nitrobenzene intermediates which are ultimately converted into amines 2, R 1  and/or R 3  is alkoxy, and R 2  and/or R 4  is a halogen, and X equals a bond, may be prepared by standard halogenation reactions which include the following: 
     a) reaction of a 2- or 4-hydroxy-nitrobenzene with aqueous sodium hypochlorite (Methods 7A and 7B), at room temperature or; 
     b) reaction of a 2-hydroxy-4-methoxy or 2,4-dimethoxynitrobenzene (Method 7C and 7D) with bromine in suitable solvent such as chloroform, dichlormethane, glacial acetic acid or the like in the presence or the absence of silver trifluoroacetate at room temperature, or; 
     c) reaction of a 2,4-dimethoxynitrobenzene (Method 7E) with benzyltrimethyl-ammonium dichloroiodate in the presence of anhydrous zinc chloride in a suitable solvent such as glacial acetic acid, at room temperature or; 
     d) reaction of a 2-hydroxy-4-methoxynitrobenzene (Method 7F) with benzyltrimethyl-ammonium dichloroiodate in the presence of sodium bicarbonate in a suitable solvent mixture such as dichloromethane and methanol, at room temperature or; 
     e) reaction of a 2,4-dimethoxynitrobenzene (Method 7G) with 3,5-dichloro-1-fluoropyridine triflate in a suitable solvent such as tetrachloroethane, at a temperature ranging from room temperature to the reflux temperature of the solvent. 
     Referring to Method 8, the nitrobenzene intermediates which are ultimately converted into amines 2, wherein R 4  =—CF 3 , and R 1 -R 3  and R 5 -R 8  are defined as above and X equals a bond may be prepared from the corresponding substituted 4-iodo-nitrobenzenes by reaction with trimethyl(trifluoromethyl)silane in the presence of cuprous iodide and potassium fluoride in a suitable solvent such as N,N-dimethylformamide or the like at a temperature ranging from room temperature to the reflux temperature of the solvent in a sealed reaction vessel. 
     Referring to Methods 19A and 19B, the nitrobenzene intermediates which are ultimately converted into amines 2, wherein R 4 =—HNCOCH 2 NR 7 R 8  or —HNCOCH 2 SR 6 , and R 1 -R 3  and R 5  are defined as above and X equals a bond may be prepared from the corresponding substituted 4-(N-chloroacetyl)-nitroaniline by reaction with either a suitable secondary amine such as dimethylamine, morpholine or the like in a suitable solvent such as tetrahydrofuran and/or water mixtures at temperatures ranging from room temperature to the reflux temperature of the solvent or by reaction with an appropriate thiol in the presence of a suitable base such as sodium or potassium carbonate or the like in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Referring to Method 25, the nitrobenzene intermediates which are ultimately converted into amines 2, wherein at least one substituent of R 1 -R 5  is defined as triflate and X equals a bond may be prepared from the corresponding phenol by reaction with trifluoromethane-sulfonic anhydride in the presence of a tertiary amines such as triethylamine or diisopropyl-ethylamine or the like in a suitable solvent such as dichloromethane at temperatures ranging from 0° C. to room temperature. 
     Referring to Methods 9, 9B, and 10, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein at least one substituent R 1 -R 5  is defined as either alkylsulfenyl or alkylsulfinyl, may be prepared by reaction of the appropriate 4-alkylthio acyl-arylamino or carbamoyl arylamino derivative with an appropriate oxidizing agent such as dimethyloxirane or sodium periodate in a suitable solvent mixture such as acetone and dichloromethane or water at room temperature. 
     Referring to Method 12, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as 1-hydroxyethyl and R 1 -R 3  and R 5  are defined as above and X is a bond may be prepared by reacting the corresponding 4-vinyl carbamoyl aniline with sodium borohydride in the presence of mercuric acetate in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like and water at room temperature. 
     Referring to Method 13, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as 2-hydroxyethyl and R 1 -R 3  and R 5  are defined as above and X equals a bond, may be prepared by reacting the corresponding 4-vinyl carbamoyl aniline with sodium borohydride in the presence of glacial acetic acid in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like at temperatures ranging from 0° C. to room temperature. 
     Referring to Method 14, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as 1-azidoethyl and R 1 -R 3  and R 5  are defined as above and X is defined above, may be prepared by reacting the corresponding 4-(1-hydroxyethyl)carbamoyl aniline with hydrazoic acid in the presence of a dialkylazodicarboxylate such as diethylazodicarboxylate and triphenylphosphine in a suitable solvent mixture such as tetrahydrofuran and dichloromethane at temperatures ranging from 0° C. to room temperature. 
     Referring to Method 15, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as 3-dimethylaminoprop-1-ynyl and R 1 -R 3  and R 5  are defined as above and X is defined above, may be prepared by reacting the corresponding 4-iodocarbamoyl aniline with 1-dimethylamino-2-propyne in a suitable tertiary amine solvent such as triethylamine or diisopropylethylamine in the presence of bis(triphenylphosphine)-palladium(II) chloride and cuprous iodide at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Referring to Method 16, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as 3-dimethylaminoacryloyl and R 1 -R 3  and R 5  are defined as above and X equals a bond, may be prepared by reacting the corresponding 4-(3-dimethylaminoprop-1-ynyl)carbamoyl aniline with a suitable peracid such as 3-chloroperoxybenzoic acid in a suitable solvent mixture such as dichloromethane and methanol at temperatures ranging from 0° C. to room temperature. 
     Referring to Methods 17 and 18, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4  is defined as either 4-isoxazol-5-yl or 4-(1H-pyrazol-3-yl) and R 1 -R 3  and R 5  are defined as above and X equals a bond, may be prepared by reacting the corresponding 4-(3-dimethylamino-acryloyl)carbamoyl aniline with either hydroxylamine hydrochloride or hydrazine hydrate in a suitable solvent such as 1,4-dioxane or ethanol and the like at room temperature. 
     Referring to Method 20, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein R 4 =—HNCO 2 Z, and R 1 -R 3 , R 5 , and Z are defined as above and X equals a bond, may be prepared by reacting the corresponding 4-aminocarbamoyl aniline with 1,1-carbonyl-di-(1,2,4)-triazole and an appropriately substituted alcohol in a suitable solvent mixture such as tetrahydrofuran and dichloromethane and the like at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Referring to Methods 26 and 30, the carbamoyl amine derivatives utilized as starting materials in Methods 3A-3C which are ultimately converted into amines 2, wherein at least one substituent of R 1 -R 5  is defined as dialkylamino and X is defined above may be prepared by reaction of appropriately substituted aldehydes in the presence of either sodium cyanoboro-hydride or hydrogen gas and 10% palladium on carbon in a suitable solvent such as water, methanol, tetrahydrofuran mixtures or toluene or the like at room temperature. 
     Referring to Methods 27 and 28, amines 2 wherein at least one substituent of R 1 -R 5  is defined as hydroxy and X is defined above can be prepared by reaction of the corresponding ester such as acetate with an appropriate base such as sodium bicarbonate or sodium hydroxide in a suitable solvent mixture such as methanol-water mixtures at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Referring to Method 29, amines 2 wherein at least one substituent of R 1 -R 5  is defined as 2-hydroxybenzamido and X is defined above can be prepared by reaction of the corresponding N-(4-aminophenyl)phthalimide with lithium borohydride in an appropriate solvent such as tetrahydrofuran, diethyl ether, or the like at room temperature. 
     The intermediate amines 2 wherein R 1 -R 5  are defined as above and X equals either —CH 2 — or —(CH 2 ) 2 — can be prepared by the following procedures: 
     a) reduction of an appropriately substituted benzo- or phenylacetonitrile with borane-dimethylsulfide complex in a suitable solvent such as ethylene glycol dimethyl ether, tetrahydrofuran or the like a temperatures ranging from room temperature to the reflux temperature of the solvent. (Method 44); 
     b) reduction under one or more atmospheres of hydrogen in the presence of a suitable catalyst such as 5% or 10% palladium on carbon and an acid such as 4-methyl-benzenesulfonic acid, hydrochloric acid or the like in a suitable solvent such as ethylene glycol monomethyl ether, ethyl acetate, ethanol or the like at room temperature. (Method 50); 
     c) reduction with lithium aluminum hydride in a suitable solvent such as tetrahydrofuran or diethyl ether at temperatures ranging from 0° C. to room temperature. (Method 51); 
     The unsaturated nitro precursors which are utilized as starting materials in Method 51 and are ultimately converted to amines 2 wherein R 1 -R 5  are defined as above and X equals —(CH 2 ) 2 — can be prepared by reaction of an appropriately substituted benzaldehyde with nitro-methane in the presence of ammonium acetate in a suitable solvent such as acetic acid at temperatures ranging from room temperature to the reflux temperature of the solvent.(Method 53); The benzaldehydes, utilized as starting materials in Method 53, can be prepared by diisobutylaluminum hydride reduction of an appropriately substituted benzonitrile. (Method 52) The substituted benzonitriles, utilized as starting materials in Method 52, can be prepared from the corresponding aryl bromide by reaction with copper cyanide in a suitable solvent such as N,N-dimethylformamide at temperatures ranging from room temperature to the reflux temperature of the solvent. (Method 59) 
     For amines 2, wherein R 1 -R 5  is defined as above and X equals either —O(CH 2 ) 2 NH 2  or —S(CH 2 ) 2 NH 2 , the requisite nitrile precursors may be prepared by reaction of an appropriately substituted phenol or thiophenol with bromoacetonitrile in the presence of a suitable base such as potassium carbonate in an appropriate solvent such as acetone at room temperature according to Method 49. 
     Alternatively, for amines 2, wherein R 1 -R 5  are defined as above and X equals —(CH 2 ) 3 —, the nitrile precursors can be prepared essentially according to the procedure of Wilk, B.  Synthetic Comm.  23, 2481 (1993), by reaction of an appropriately substituted phenethanol with acetone cyanohydrin and triphenylphosphine in the presence of a suitable azodicarboxylate such as diethyl azodicarboxylate in an appropriate solvent such as diethyl ether or tetrahydro-furan or the like at temperatures ranging from 0° C. to room temperature. (Method 54) 
     Alternatively, intermediate amines 2 wherein R 1 -R 5  are defined as above and X equals —(CH(CH 3 ))— can be prepared by acid or base catalyzed hydrolysis of the corresponding formamide using an appropriate acid catalyst such as 6N hydrochloric acid or a suitable base catalyst such as 5N sodium or potassium hydroxide in an appropriate solvent mixture such as water and methanol or water and ethanol at temperatures ranging from room temperature to the reflux temperature of the solvent. (Method 46) 
     The formamide precursors utilized as starting materials in Method 46 and which are ultimately converted into amines 2, are prepared according to Method 45 by treatment of an appropriately substituted acetophenone with ammonium formate, formic acid and formamide at temperatures ranging from room temperature to the reflux temperature of the solvent. 
     Alternatively, amines 2 wherein R 1 -R 5  are defined as above and X equals —(CH(CH 3 ))— can be prepared by reduction of an appropriately substituted O-methyl oxime in the presence of sodium borohydride and zirconium tetrachloride in a suitable solvent such as tetrahydrofuran or diethyl ether at room temperature Method 48 essentially according to the procedure of Itsuno, S., Sakurai, Y., Ito, K.  Synthesis  1988, 995. The requisite O-methyl oximes can be prepared from the corresponding acetophenone by reaction with methoxylamine hydrochloride and pyridine in a suitable solvent such as ethanol or methanol at temperatures ranging from room temperature to the reflux temperature of the solvent. (Method 47) 
     Amines 2 for which R 1 -R 5  are defined as above and X equals —CH(J)— where J is defined as above, can be prepared by reduction of the appropriately substituted ketone by the methods described above (Methods 45, 47, and 48). These requisite ketones, when not commercially available, can be prepared by reaction of a suitably substituted benzaldehyde with an appropriate organometallic reagent such as phenyllithium, isopropylmagnesium bromide or ethylmagnesium bromide or the like in a suitable solvent such as diethyl ether or tetrahydrofuran at temperatures ranging from −78° C. to 0° C. (Method 57) The resulting alcohols can be oxidized to the corresponding ketone with an appropriate oxidizing agent such as chromium trioxide in aqueous sulfuric acid and acetone or pyridinium chlorochromate or pyridium dichromate in an appropriate solvent such as dichloromethane or the like at room temperature. (Method 58) 
     The intermediate anilines 5 may be prepared as previously described Method 3A. Thus treating phenyl carbamic acid tert-butyl ester 6, G is described as above, with neat trifluoroacetic acid at room temperature followed by neutralization with aqueous sodium hydroxide affords the desired anilines 5. The requisite carbamic acid esters 6, wherein G is described as above, are prepared as shown in Method 2C by reaction of substituted acid chlorides, 8, where G is described as above, and 4-aminophenylcarbamic acid tert-butyl esters 7 in the presence of triethylamine in an appropriate solvent such as dichloromethane, dimethylsulfoxide, or dimethylformamide or mixtures thereof. Carboxylic acid chlorides 8 are either commercially available or prepared from the corresponding carboxylic acid by reaction with oxalyl chloride in a suitable solvent such as dichloromethane at room temperature.                           
     Alternatively, carbamic acid esters 6, wherein G is described as above, are prepared as shown in Method 2E by reaction of substituted carboxylic acids 8a, wherein G is described as above, and an appropriately substituted 4-aminophenyl carbamic acid tert-butyl esters 7 in the presence of a suitable coupling agent such as benzotriazole-1-yloxy-tris-(dimethylamino)phosphonium hexafluorophosphate, 2-(1H-benzotriazole-1-yloxy)-1,1,3,3-tetramethyluronium hexafluorophosphage, dicyclohexyl carbodiimide or the like and in the presence of a tertiary amine base such as triethylamine or diisopropylethylamine in a suitable solvent such as dichloromethane, dimethylformamide and the like, at room temperature to produce the corresponding arylaminoamide. 
     Carboxylic acids 8a are either commercially available or are prepared according to literature methods. For example, when G is a substituted thiadiazole, the acid is available from the corresponding carboxylic acid ester by reaction with an appropriate base such as sodium or potassium hydroxide in a suitable solvent mixture such as methanol or ethanol and water at room temperature. 
     Similarly, when G is either substituted or unsubstituted thiazole, substituted or unsubstituted oxazole, substituted or unsubstituted isothiazole, or substituted or unsubstituted isoxazole, when not commercially available, the corresponding carboxylic acid 8a is available from the corresponding ethyl or methyl ester by reaction with an appropriate base such as sodium or pottasium hydroxide in a suitable solvent mixture such as methanol or ethanol and water at room temperature. These esters are either commercially available or can be prepared according to literature methods. 
     When the carboxylic acid ester precursors which are ultimately converted to acids 8 are not commmercially available, they may be prepared by methods known in the literature. For example, 5-substituted-1,2,3-thiadiazole-4 carboxylic acid esters may be prepared essentially according to the procedure of Caron, M  J. Org. Chem.  51, 4075 (1986) and Taber, D. F., Ruckle, R. E.  J. Amer. Chem. Soc.  108, 7686 (1986). Thus, according to Method 21, treatment of a beta-keto carboxylic acid ester with 4-methylbenzenesulfonyl azide or methanesulfonyl azide or the like in the presence of a tertiary amine base such triethylamine or diisopropylethylamine in a suitable solvent such as acetonitrile affords the corresponding diazo-beta-keto carboxylic acid ester. Treatment of this compound with 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide in a suitable solvent such as benzene or toluene or the like at temperatures ranging from room temperature to the reflux temperature of the solvent gives the desired 5-substituted-1,2,3-thiadiazole-4-carboxylic acid ester. 
     Alternatively, 4-substituted-1,2,3-thiadiazole-5-carboxylic acid esters may be prepared essentially according to the procedure of Shafiee, A., Lalezari, I., Yazdani, S., Shahbazian, F. M., Partovi, T.  J. Pharmaceutical Sci.  65, 304 (1976). Thus, according to Method 22 and 23, reaction of an appropriately substituted beta-keto carboxylic acid ester in a suitable alcoholic solvent such as methanol or ethanol with an aqueous solution semicarbazide hydrochloride at temperatures ranging from room temperature to the reflux temperature of the solvent in the presence of a suitable base such as pyridine gives corresponding semicarbazone derivative. Treatment of this compound with neat thionyl chloride at 0° C. followed by treatment with an excess aqueous solution of sodium bicarbonate affords the corresponding 4-substituted-1,2,3-thiadiazole-5-carboxylic acid esters. 
     4-carboalkoxythiazoles are prepared essentially according to the procedure of Schöllkopf, U., Porsch, P., Lau, H.  Liebigs Ann. Chem.  1444 (1979). Thus, according to Method 55 and 56, reaction of ethyl isocyanoacetate with N,N-dimethylformamide dimethyl acetal in a suitable alcoholic solvent such as ethanol at room temperature gives the corresponding 3-dimethylamino-2-isocyano-acrylic acid ethyl ester. A solution of this compound in a suitable solvent such as tetrahydrofuran is treated with gaseous hydrogen sulfide in the presence of a suitable tertiary amine base such as triethylamine or diiso-propylethylamine or the like at room temperature to give the corresponding 4-carboethoxy-thiazole. 
     Additional appropriately substituted thiazoles may be prepared essentially according to the procedure of Bredenkarnp, M. W., Holzafel, C. W., van Zyl, W.  J. Synthetic Comm.  20, 2235 (1990). Appropriate unsaturated oxazoles are prepared essentially according to the procedure of Henneke, K. H., Schöllkopf, U., Neudecker, T.  Liebigs Ann. Chem.  1979 (1979). Substituted oxazoles may be prepared essentially according to the procedures of Galeotti, N., Montagne, C., Poncet, J., Jouin, P.  Tetrahedron Lett.  33, 2807, (1992) and Shin, C., Okumura, K., Ito, A., Nakamura, Y.  Chemistry Lett.  1305, (1994). 
    
    
     The following specific examples are illustrative, but are not meant to be limiting of the present invention. 
     EXAMPLE 1 (METHOD 1A) 
     4-Methoxy-3-trifluoromethyl-phenylamine 
     A suspension of 4-methoxy-3-trifluoromethyl-nitrobenzene (2.2 g) and iron powder (1.68 g) in ethanol (35 mL) and water (15 mL) is treated with a solution of concentrated hydrochloric acid (0.42 mL) in ethanol (6 mL) and water (3 mL) and the mixture is heated to reflux for approximately 1 hour. The mixture is then cooled, filtered, and concentrated under reduced pressure. The resulting oil is dissolved in ethyl acetate and extracted three times with 5% aqueous hydrochloric acid. The pooled acidic extracts are then cooled in an ice bath and basified with solid potassium carbonate, then extracted with ethyl acetate. These organic extracts are washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated under reduced pressure, then passed through a short column of silica gel (ethyl acetate is used as the eluant) to provide the desired compound as an amber oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     2,6-Dichloro-benzene-1,4-diamine 
     3-Chloro-4-methylsulfanyl-phenylamine 
     2,6-Dibromo-benzene-1,4-diamine 
     3-Chloro-4-trifluoromethyl-phenylamine 
     3-Chloro-4-ethylsulfanyl-phenylamine 
     4-Methoxy-3-trifluoromethyl-phenylamine 
     3,5-Dichloro-4-methoxy-2-methyl-phenylamine 
     5-Chloro-2-ethoxy-4-methoxy-phenylamine 
     5-Chloro-4-ethoxy-2-methoxy-phenylamine 
     5-Iodo-2,4-dimethoxy-phenylamine 
     3,5-Diiodo-2,4-dimethoxy-phenylamine 
     3,5-Dibromo-2,4-dimethoxy-phenylamine 
     5-Chloro-2-methoxy-4-methyl-phenylamine 
     2-Chloro-N(1),N(1)-dimethyl-benzene-1,4-diamine 
     3-Chloro-4-piperidin-1-yl-phenylamine 
     3-Chloro-4-pyrrolidin-1-yl-phenylamine 
     N(1)-Benzyl-2-chloro-benzene-1,4-diamine 
     3-Chloro-4-(4-methyl-piperazin-1-yl)-phenylamine 
     2-Chloro-N(1)-methyl-N(1)-(1-methyl-piperidin-4-yl)-benzene-1,4-diamine 
     2-Chloro-N(1)-methyl-N(1)-(1-methyl-pyrrolidin-3-yl)-benzene-1,4-diamine 
     2-Chloro-N(1)-methyl-N(1)-phenyl-benzene-1,4-diamine 
     N(1)-(1-Benzyl-pyrrolidin-3-yl)-2-chloro-N(1)-methyl-benzene-1,4-diamine 
     2-Chloro-N(1)-cyclopentyl-N(1)-methyl-benzene-1,4-diamine 
     2-[(4-Amino-2-chloro-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol 
     2-Chloro-N(1)-hexyl-N(1)-methyl-benzene-1,4-diamine 
     2-Chloro-N(1)-isobutyl-N(1)-methyl-benzene-1,4-diamine 
     2-[(4-Amino-2-chloro-phenyl)-methyl-amino]-ethanol 
     2-Chloro-N(1)-(3-dimethylamino-propyl)-N(1)-methyl-benzene-1,4-diamine 
     2-Chloro-N(1)-(2-dimethylamino-ethyl)-N(1)-methyl-benzene-1,4-diamine 
     2-Chloro-N(1)-(2-dimethylamino-ethyl)-benzene-1,4-diamine 
     N(1)-(1-Benzyl-piperidin-4-yl)-2-chloro-benzene-1,4-diamine 
     2-Chloro-N(1)-(2-methoxy-ethyl)-N(1)-methyl-benzene-1,4-diamine 
     2-Chloro-N(1)-(3-dimethylamino-propyl)-benzene-1,4-diamine 
     N(1)-(1-Benzyl-pyrrolidin-3-yl)-2-chloro-benzene-1,4-diamine 
     3-Chloro-4-(1-methyl-piperidin-4-yloxy)-phenylamine 
     3-Chloro-4-(2-dimethylamino-ethoxy)-phenylamine 
     3-Chloro-4-(3-dimethylamino-propoxy)-phenylamine 
     3-Chloro-4-(1-methyl-pyrrolidin-3-yloxy)-phenylamine 
     3-Chloro-4-cyclohexyloxy-phenylamine 
     EXAMPLE 2 (METHOD 1B) 
     4-Bromo-2,4-dimethoxy-phenylamine 
     A suspension of 4-bromo-2,4-dimethioxy-nitrobenzene (0.48 g) and iron powder (0.42 g) in acetic acid (10 mL) and ethanol (10 mL) is heated to 120° C. for approximately 5 hours. The mixture is then cooled, filtered, and concentrated under reduced pressure. Water is added and the mixture is cooled in an ice bath and neutralized with solid potassium carbonate and then extracted with dichloromethane. These organic extracts are washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated under reduced pressure, then chromatographed over silica gel (20% ethyl acetate in hexanes is used as the eluant) to provide the desired compound as an amber oil. 
     EXAMPLE 3 (METHOD 1C) 
     (4-Amino-2,6-dichloro-phenoxy)-acetic acid tert-butyl ester 
     A solution of (4-nitro-2,6-dichloro-phenoxy)-acetic acid tert-butyl ester (1 g) in ethanol (17 mL) and water (8.6 mL) is treated with iron powder (0.861 g) and ammonium chloride (86 mg) and the mixture is heated to reflux for approximately 1 hour. The mixture is then filtered and concentrated under reduced pressure. The resulting oil is partitioned between water and ethyl acetate, and the organic phase is then washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to provide the desired compound as a pale yellow solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     4-Chloro-benzene-1,2-diamine 
     N-(4-Amino-2-chloro-phenyl)-acetamide 
     (4-Amino-2,6-dichloro-phenoxy)-acetonitrile 
     (4-Amino-2,6-dichloro-phenoxy)-acetic acid tert-butyl ester 
     (2-Amino-4-chloro-5-methoxy-phenoxy)-acetonitrile 
     (4-Amino-2-chloro-5-methoxy-phenoxy)-acetic acid methyl ester 
     (4-Amino-2-chloro-5-methoxy-phenoxy)-acetic acid tert-butyl ester 
     (2-Amino-4-chloro-5-methoxy-phenoxy)-acetic acid tert-butyl ester 
     N(1)-Benzyl-4-chloro-5-methoxy-benzene-1,2-diamine 
     N-(4-Amino-2-chloro-phenyl)-2-fluoro-benzamide 
     N-(4-Amino-5-chloro-2-hydroxy-phenyl)-acetamide 
     N-(4-Amino-5-chloro-2-hydroxy-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2-chloro-phenyl)-amide 
     (4-Amino-2-chloro-phenyl)-carbamic acid ethyl ester 
     N-(4-Amino-5-chloro-2-methyl-phenyl)-acetamide 
     N-(4-Amino-5-chloro-2-methyl-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-5-chloro-2-methyl-phenyl)amide 
     N-(4-Amino-3-chloro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-3-chloro-phenyl)-amide 
     N-(4-Amino-2-chloro-phenyl)-2-dimethylamino-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-piperidin-1-yl-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-morpholin-4-yl-acetamide 
     N-(4-Amino-2-chloro-phenyl)-methanesulfonamide 
     N-(4-Amino-2-chloro-phenyl)-benzamide 
     N-(4-Amino-2-chloro-phenyl)-2-diethylamino-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-pyrrolidin-1-yl-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-azepan-1-yl-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-(2-methyl-piperidin-1-yl)-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-(3-methyl-piperidin-1-yl)-acetamide 
     3-Chloro-benzene-1,2-diamine 
     4-Chloro-N,N-dimethyl-benzene-1,2-diamine 
     EXAMPLE 4 (METHOD 1D) 
     3,5-Dichloro-4-phenoxy-phenylamine 
     To a slurry of 3,5-dichloro-4-phenoxy-nitrobenzene (6.1 g) and tin powder (12 g) is added dropwise concentrated hydrochloric acid (60 mL). Ethanol (60 mL) is added and the mixture is heated to reflux for approximately 1 hour. The mixture is then cooled in an ice bath and basified by addition of solid sodium hydroxide. The resulting suspension is filtered through a pad of diatomaceous earth and extracted three times with ethyl acetate. The combined organic extracts are then washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to provide the desired product as a yellow solid. Recrystallization from ethyl acetate-hexanes provided the product as a pale yellow solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     1-Furan-2-yl-ethylamine 
     3-Chloro-4-isopropoxy-phenylamine 
     2-Butoxy-5-chloro-4-methoxy-phenylamine 
     3,5-Dichloro-2-methoxy-4-methyl-phenylamine 
     2-Benzyloxy-5-chloro-4-methoxy-phenylamine 
     4-Benzyloxy-5-chloro-2-methoxy-phenylamine 
     5-Fluoro-2,4-dimethoxy-phenylamine 
     (4-Amino-2,6-dichloro-phenoxy)-acetic acid ethyl ester 
     3,5-Dichloro-4-phenoxy-phenylamine 
     2-(4-Amino-2-chloro-5-methoxy-phenoxy)-acetamide 
     (4-Amino-2-chloro-5-methoxy-phenoxy)-acetonitrile 
     2-(2-Amino-4-chloro-5-methoxy-phenoxy)-ethanol 
     2-(4-Amino-2-chloro-5-methoxy-phenoxy)-ethanol 
     4-(4-Amino-2-chloro-5-methoxy-phenoxy)-butyronitrile 
     4-Amino-2-chloro-5-methoxy-phenol 
     2-Amino-4-chloro-5-methoxy-phenol 
     5-Chloro-4-methoxy-2-morpholin-4-yl-phenylamine 
     4-Chloro-5-methoxy-N(1),N(1)-dimethyl-benzene-1,2-diamine 
     5-Chloro-4-methoxy-2-piperidin-1-yl-phenylamine 
     5-Chloro-4-methoxy-2-pyrrolidin-1-yl-phenylamine 
     2-Chloro-N(1)-cyclohexyl-N(1)-methyl-benzene-1,4-diamine 
     N(2)-Benzyl-4-methoxy-benzene-1,2-diamine 
     2-(4-Amino-2-chloro-phenoxy)-ethanol 
     2-Chloro-N(1)-cyclohexyl-N(1)-ethyl-benzene-1,4-diamine 
     4-Butoxy-3-chloro-phenylamine 
     (4-Amino-2-chloro-phenoxy)-acetonitrile 
     2-Chloro-N(1)-cyclohexyl-benzene-1,4-diamine 
     2-Chloro-N(1),N(1)-dipropyl-benzene-1,4-diamine 
     3-Chloro-4-(2,2,2-trifluoro-ethoxy)-phenylamine 
     3-Chloro-4-(octahydro-quinolin-1-yl)-phenylamine 
     N(1)-Allyl-2-chloro-N(1)-cyclohexyl-benzene-1,4-diamine 
     N-(4-Amino-2-methoxy-5-methyl-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2-methoxy-5-methyl-phenyl)amide 
     N-(4-Amino-naphthalen-1-yl)-2-fluoro-benzamide 
     3-Chloro-N,N-dimethyl-benzene-1,2-diamine 
     3-Chloro-4-propoxy-phenylamine 
     3-Iodo-4-methoxy-phenylamine 
     3-Chloro-2,4-dimethoxy-aniline 
     3-Bromo-4-methoxy-phenylamine 
     3-Chloro-4-ethoxy-phenylamine 
     EXAMPLE 5 (Method 1E) 
     (4-Amino-phenyl)-carbamic acid isobutyl ester 
     To a solution of N-(4-Nitro-phenyl)-isobutyrlamide (2.0 g) in 100 mL ethylene glycol monomethyl ether (100 mL) is added 10% palladium on carbon (275 mg). The mixture is hydrogenated for 2 hours at room temperature under 30 psi of hydrogen on a Parr hydrogenation apparatus. The catalyst is then removed by filtration through diatomaceous earth and the filtrate is evaporated to dryness under reduced pressure by azeotroping three times with heptane. Trituration of the residue with heptane provides the desired product as a white solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     2-Methyl-3H-benzoimidazol-5-ylamine 
     N-(4-Amino-phenyl)-formamide 
     1H-Benzoimidazol-5-ylamine 
     (4Amino-phenyl)-carbamic acid isobutyl ester 
     N-(4-Amino-phenyl)-isobutyramide 
     N-(5-Amino-pyridin-2-yl)-2-methyl-benzamide 
     Furan-2-carboxylic acid (5-amino-pyridin-2-yl)-amide 
     N-(5-Amino-pyridin-2-yl)-2-fluoro-benzamide 
     [6-(2,2,2-Trifluoro-acetylamino)-pyridin-3-yl]-carbamic acid tert-butyl ester 
     N-(5-Amino-pyridin-2-yl)-2,2,2-trifluoro-acetamide 
     (4-Amino-benzyl)-carbamic acid tert-butyl ester 
     2-(3,5-Bis-trifluoromethyl-phenyl)-ethylamine 
     1-tert-Butyl-1H-imidazol-2-ylamine 
     3-(3-Dimethylamino-propyl)-5-trifluoromethyl-phenylamine 
     EXAMPLE 6 (METHOD 1F) 
     N-(4-Amino-2-methylphenyl)-2-fluorobenzamide 
     A mixture of 2-fluoro-N-(2-methyl-4-nitrophenyl)benzamide (4.55 g), cyclohexene (30 mL), ethanol (70 mL), water (30 mL) and 10% palladium on charcoal (3 g) is heated at reflux for 30 minutes. The mixture is filtered through diatomaceous earth and concentrated under reduced pressure. The resulting oil is dissolved in 50 mL of ethyl acetate and cooled at 4° C. for 12 hours. Filtration provides the product as a tan solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(4-Amino-2-methyl-phenyl)-acetamide 
     2-Methyl-benzooxazol-6-ylamine 
     N-(4-Amino-3-methoxy-phenyl)-acetamide 
     2-Acetylamino-5-amino-benzoic acid 
     N-(4-Amino-phenyl)-acetamide 
     [4-(3-Amino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Amino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     N-(4-Amino-2-cyano-phenyl)-acetamide 
     N-(4-Amino-2,5-dimethoxy-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2,5-dimethoxy-phenyl)-amide 
     N-(4-Amino-2-cyano-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2-methoxy-phenyl)-amide 
     N-(4-Amino-2-methoxy-phenyl)-2-fluoro-benzamide 
     N-(4-Amino-2-methoxy-5-methyl-phenyl)-acetamide 
     N-(4-Amino-2-benzoyl-phenyl)-acetamide 
     N-(4-Amino-2-benzoyl-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2-benzoyl-phenyl)-amide 
     N-(4-Amino-3-methyl-phenyl)-acetamide 
     N-(4-Amino-3-methyl-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-3-methyl-phenyl)-amide 
     5-Amino-2-[(2-fluorobenzoyl)amino]-N-phenylbenzamide 
     Furan-2-carboxylic acid (4-amino-2-phenylcarbamoyl-phenyl)amide 
     N-(4-Amino-naphthalen-1-yl)-acetamide 
     Furan-2-carboxylic acid (4-amino-naphthalen-1-yl)-amide 
     N-(4-Amino-2-trifluoromethyl-phenyl)-acetamide 
     Furan-2-carboxylic acid (4-amino-2-cyano-phenyl)-amide 
     Furan-2-carboxylic acid (4-amino-2-trifluoromethyl-phenyl)-amide 
     N-(4-Amino-2-methyl-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-2-methyl-phenyl)-amide 
     5-Amino-2-(2-fluoro-benzoylamino)-benzoic acid 
     5-Amino-2-[(furan-2-carbonyl)-amino]-benzoic acid 
     N-(4-Amino-2-cyano-phenyl)-2,2,2-trifluoro-acetamide 
     N-(4-Amino-3-methyl-phenyl)-2,6-difluoro-benzamide 
     N-(4-Amino-3-trifluoromethyl-phenyl)-acetamide 
     N-(4-Amino-3-trifluoromethyl-phenyl)-2-fluoro-benzamide 
     N-(4-Amino-2-trifluoromethyl-phenyl)-2,2,2-trifluoro-acetamide 
     N-(4-Amino-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
     N-(4-Amino-2-trifluoromethyl-phenyl)-2-fluoro-N-(2-fluoro-benzoyl)-benzamide 
     N-(4-Amino-2-trifluoromethyl-phenyl)-2-fluoro-benzamide 
     EXAMPLE 7 (METHOD 1G) 
     N-(4-Amino-2-chlorophenyl)-2-thiomorpholino-4-yl-acetamide 
     A solution of N-(2-chloro-4-nitrophenyl)-2-thiomorpholino-4-yl-acetamide (3.02 g) in ethanol (200 mL) is added to a solution of sodium thiosulfate (12 g) in water (60 mL). The mixture is heated at reflux for 12 hours, cooled and poured into water. The mixture is then extracted with ethyl acetate. The ethyl acetate solution is washed twice with saturated aqueous sodium chloride, dried over anhydrous potassium carbonate, filtered through a pad of diatomaceous earth and concentrated under reduced pressure to give an oil. Toluene is added and the solution chilled to give the desired product as a light orange crystalline solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(4-Amino-2-chloro-phenyl)-2-thiomorpholin-4-yl-acetamide 
     N-(4-Amino-2-chloro-phenyl)-2-dipropylamino-acetamide 
     EXAMPLE 8 (METHOD 2A) 
     (3-Chloro-4iodo-phenyl)-carbamic acid tert-butyl ester 
     To a solution of 3-chloro-4-iodo-aniline (10 g) in tetrahydrofuran (40 mL) containing diiso-propylethylamine (6.9 mL) is added di-tert-butyl-dicarbonate (8.6 g) and the mixture is heated to reflux. After approximately 15 hours additional portions of diisopropylethylamine (6.9 mL) and di-tert-butyl-dicarbonate (21 g) is added and heating is continued for approximately 24 hours. The solution is then cooled, concentrated under reduced pressure, diluted with ethyl acetate, and washed successively three times with 5% aqueous hydrochloric acid then once with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate then concentrated under reduced pressure to provide the desired crude product as a brown oil. Crystallization is induced by addition of hexanes, and the collected solid material is recrystallized from hexanes to give the desired product as a white solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N′-(4-Nitro-benzoyl)-hydrazinecarboxylic acid tert-butyl ester 
     (3-Chloro-4-iodo-phenyl)-carbamic acid tert-butyl ester 
     (4-Bromo-3-chloro-phenyl)-carbamic acid tert-butyl ester 
     (3-Chloro-4-vinyl-phenyl)-carbamic acid tert-butyl ester 
     (3-Chloro-4-methylsulfanyl-phenyl)-carbamic acid tert-butyl ester 
     (4-Amino-3-chloro-phenyl)-carbamic acid tert-butyl ester 
     (4-Chloro-2-nitro-phenyl)-carbamic acid tert-butyl ester 
     (3-tert-Butoxycarbonylamino-5-chloro-phenyl)-carbamic acid tert-butyl ester 
     (4-Nitro-benzyl)-carbamic acid tert-butyl ester 
     (3-Bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
     (2-Amino-3-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
     EXAMPLE 9 (METHOD 2B) 
     (3-Chloro-4-vinyl-phenyl)-carbamic acid2-trimethylsilanyl-ethyl ester 
     To a solution of 3-chloro-4-vinyl-phenylamine (3.4 g) in N,N-dimethylformamide (44 mL) containing diisopropylethylamine (5.8 mL) is added 1-[2-(trimethylsilyl)-ethoxycarbonyl-oxy]benzotriazole (7.1 g) and the mixture is stirred at room temperature under an atmosphere of argon for three days. The solution is then diluted with water and extracted three times with diethyl ether. The combined organic extracts are washed successively with water, saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue is chromatographed over silica gel (10% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a yellow oil. 
     EXAMPLE 10 (METHOD 2C) 
     [4-(2-Fluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     To a solution of mono-N-(t-butoxycarbonyl)-1,4-phenylenediamine (1.58 g) and triethylamine (1.50 mL) in 25 mL of dichloromethane is added o-fluorobenzoyl chloride (1.20 g). A solid formed immediately forms and is filtered and washed with fresh solvent to yield a white solid, 1.90 g. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(3-Methoxy-4-nitro-phenyl)-acetamide 
     N-(4-Amino-phenyl)-isobutyrlamide 
     2,2,2-Trifluoro-N-(2-methoxy-4-nitro-phenyl)-acetamide 
     [4-(2-Methyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     Acetic acid 2-(4-tert-butoxycarbonylamino-phenylcarbamoyl)-phenyl ester 
     [4-(4-Fluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(3-Fluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Fluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Methoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(3-Methoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(4-Methoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,2-Dimethyl-propionylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Bromo-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     (4-Benzoylamino-phenyl)-carbamic acid tert-butyl ester 
     (4-Methanesulfonylamino-phenyl)-carbamic acid tert-butyl ester 
     (4-Phenylacetylamino-phenyl)-carbamic acid tert-butyl ester 
     {4-[(Thiophene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [4-(3-Nitro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(3-Acetylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(3-Methanesulfonylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     Ethyl [3-[[[4-[[(1,1,-dimethylethoxy)carbonyl]amino]phenyl]amino]carbonyl]phenyl]-carbamate 
     [4-(2-Trifluoromethyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,6-Difluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Chloro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Bromo-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Nitro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[(Benzo[b]thiophene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Pyridine-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Naphthalene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Naphthalene-1-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(3-Bromo-thiophene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Biphenyl-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     N-(4-tert-Butoxycarbonylamino-phenyl)-phthalamic acid 
     [4-(2,3-Difluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,5-Difluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,4-Difluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Acetylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2-Methanesulfonylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,3,4-Trifluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(2,3,4,5,6-Pentafluoro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     N-(4-tert-Butoxycarbonylamino-phenyl)-isophthalamic acid methyl ester 
     2-Methylsulfanyl-N-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-benzamide 
     [4-(3-Benzyloxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(3-Butoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[(5-Difluoromethyl-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Thiophene-3-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-Methyl-furan-2-carbonyl)-amino]-phenyl} -carbamic acid tert-butyl ester 
     {4-[(5-Bromo-furan-2-carbonyl)-amino]-phenyl} -carbamic acid tert-butyl ester 
     (4-Hexanoylamino-phenyl)-carbamic acid tert-butyl ester 
     [4-(2-Thiophen-2-yl-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[(Pyridine-3-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(4-Bromo-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Furan-3-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     (4-Phenoxycarbonylamino-phenyl)-carbamic acid tert-butyl ester 
     {4-[(Benzo[1,3]dioxole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [4-(3-Trifluoromethoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     N-(2,5-Dimethoxy-4-nitro-phenyl)-2-fluoro-benzamide 
     {4-[(Furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [4-(2-Phenoxy-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[(5-Nitro-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-Chloro-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(3-Methyl-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [4-(2-Methoxy-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[(4-Furan-3-yl-[1,2,3]thiadiazole-5-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-tert-Butyl-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     N-[3-Cyano-4-(2,2,2-trifluoro-acetylamino)-phenyl]-2-fluoro-benzamide 
     Furan-2-carboxylic acid [3-cyano-4-(2,2,2-trifluoro-acetylamino)-phenyl]amide 
     N-(4-Acetylamino-2-cyano-phenyl)-2,2,2-trifluoro-acetamide 
     2,2,2-Trifluoro-N-(4-nitro-2-trifluoromethyl-phenyl)-acetamide 
     N-(4-Acetylamino-2-trifluoromethyl-phenyl)-2,2,2-trifluoro-acetamide 
     2-Fluoro-N-[4-(2,2,2-trifluoro-acetylamino)-3-trifluoromethyl-phenyl]benzamide 
     Furan-2-carboxylic acid [4-(2,2,2-trifluoro-acetylamino)-3-trifluoromethyl-phenyl]amide 
     2-Fluoro-N-(2-methyl-benzooxazol-6-yl)-benzamide 
     4-(2-Fluoro-benzoylamino)-2-hydroxy-benzoic acid phenyl ester 
     {(4-[(Isoxazole-5-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     N-(4-Acetylamino-2-methoxy-phenyl)-2,2,2-trifluoro-acetamide 
     2-Fluoro-N-[3-methoxy-4-(2,2,2-trifluoro-acetylamino)-phenyl]benzamide 
     2-Fluoro-N-(2-fluoro-benzoyl)-N-(4-nitro-2-tuoromethyl-phenyl)benzamide 
     (4-[(1H-Pyrazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(1H-Imidazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-Methyl-[1,2,3]thiadiazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-Furan-3-yl-[1,2,3]thiadiazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     2,2,2-Trifluoro-N-(5-nitro-pyridin-2-yl)-acetamide 
     {4-[(1-Methyl-1H-pyrazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     4-(2-Fluoro-benzoylamino)-2-hydroxy-benzoic acid methyl ester 
     N-(5-Chloro-2,4-dimethoxy-phenyl)-oxalamic acid 
     Isoxazole-5-carboxylic acid (4-amino-phenyl)-amide 
     2-Fluoro-N-(4-nitro-benzyl)-benzamide 
     Furan-2-carboxylic acid 4-nitro-benzylamide 
     N-[3-Chloro-5-(2,2,2-trifluoro-acetylamino)-phenyl]-2,2,2-trifluoro-acetamide 
     N-(3-Amino-5-chloro-phenyl)-2,2,2-trifluoro-acetamide 
     [4-(2-Fluoro-benzoylamino)-benzyl]-carbamic acid tert-butyl ester 
     [4-(2,6-Difluoro-benzoylamino)-benzyl]-carbamic acid tert-butyl ester 
     2,6-Difluoro-N-(4-nitro-benzyl)-benzamide 
     {4-[(Furan-2-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester 
     N-(3-Amino-5-chloro-phenyl)-acetamide 
     [4-(3-Chloro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(4-Chloro-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     [4-(4-Dimethylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     4-Benzenesulfonylamino-phenyl)-carbamic acid tert-butyl ester 
     [4-(3-Trifluoromethyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     2,2-Trifluoro-N-(5-nitro-pyrimidin-2-yl)-acetamide 
     EXAMPLE 11 (METHOD 2D) 
     2-Chloro-N-(2-chloro-4-nitrophenyl)acetamide 
     A solution of 2-chloro-4-nitroaniline (19.0 g) and chloroacetyl chloride (30 mL) in tetrahydrofuran (150 mL) is heated at reflux for 1 hour. The solution is cooled and concentrated under reduced pressure, giving a wet yellow solid. Ether (250 mL) is added and the yellow solid is collected. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(4-Nitro-3-trifluoromethyl-phenyl)-acetamide 
     (2-Chloro-4-nitro-phenyl)-carbamic acid ethyl ester 
     2-Acetylamino-5-nitro-benzoic acid 
     Furan-2-carboxylic acid (5-chloro-2-hydroxy-4-nitro-phenyl)-amide 
     Furan-2-carboxylic acid (2-methyl-4-nitro-phenyl)-amide 
     Furan-2-carboxylic acid (2-methoxy-4-nitro-phenyl)-amide 
     N-(2-Chloro-4-nitro-phenyl)-benzamide 
     2-Methoxy-N-(4-nitro-phenyl)-acetamide 
     N-(4-Nitro-phenyl)-acrylamide 
     N-(4-Nitro-phenyl)-isobutyrlamide 
     [4-)acryloylamino)-phenyl]carbamic acid tert-butyl ester 
     (4-Nitro-phenyl)-carbamic acid isobutyl ester 
     [1,2,3]Thiadiazole-4-carboxylic acid (5-nitro-pyridin-2-yl)-amide 
     Furan-2-carboxylic acid (5-nitro-pyridin2-yl)-amide 
     2-Fluoro-N-(5-nitro-pyridin-2-yl)-benzamide 
     N-(2-Chloro-4-nitro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (2,5-dimethoxy-4-nitro-phenyl)-amide 
     N-(2-Cyano-4-nitro-phenyl)-2-fluoro-benzamide 
     2-Fluoro-N-(2-methoxy-4-nitro-phenyl)-benzamide 
     2-Methyl-N-(5-nitro-pyridin-2-yl)-benzamide 
     Furan-2-carboxylic acid (2-methoxy-5-methyl-4-nitro-phenyl)-amide 
     2-Fluoro-N-(2-methoxy-5-methyl-4-nitro-phenyl)-benzamide 
     N-(2-Benzoyl-4-nitro-phenyl)-acetamide 
     N-(2-Benzoyl-4-nitro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (2-benzoyl-4-nitro-phenyl)-amide 
     N-(3-Methyl-4-nitro-phenyl)-acetamide 
     2-Fluoro-N-(3-methyl-4-nitro-phenyl)-benzamide 
     Furan-2-carboxylic acid (3-methyl-4-nitro-phenyl)-amide 
     2-Acetylamino-5-nitro-N-phenyl-benzamide 
     2-[(2-Fluorobenzoyl)amino]5-nitro-N-phenylbenzamide 
     Furan-2-carboxylic acid (4-nitro-2-phenylcarbamoyl-phenyl)-amide 
     2-Fluoro-N-(4-nitro-naphthalen-1-yl)-benzamide 
     Furan-2-carboxylic acid (4-nitro-naphthalen-1-yl)-amide 
     N-(5-Chloro-2-hydroxy-4-nitro-phenyl)-acetamide 
     N-(5-Chloro-2-hydroxy-4-nitro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (2-chloro-4-nitro-phenyl)-amide 
     N-(4-Nitro-2-trifluoromethyl-phenyl)-acetamide 
     Furan-2-carboxylic acid (2-cyano-4-nitro-phenyl)-amide 
     2-Fluoro-N-(4-nitro-2-trifluoromethyl-phenyl)-benzamide 
     Furan-2-carboxylic acid (4-nitro-2-trifluoromethyl-phenyl)-amide 
     2-Fluoro-N-(2-methyl-4-nitro-phenyl)-benzamide 
     N-(5-Chloro-2-methyl-4-nitro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (5-chloro-2-methyl-4-nitro-phenyl)-amide 
     2-(2-Fluoro-benzoylamino)-5-nitro-benzoic acid 
     2-[(Furan-2-carbonyl)-amino]-5-nitro-benzoic acid 
     N-(3-Chloro-4-nitro-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (3-chloro-4-nitro-phenyl)-amide 
     2,6-Difluoro-N-(3-methyl-4-nitro-phenyl)-benzamide 
     2-Fluoro-N-(4-nitro-3-trifluoromethyl-phenyl)-benzamide 
     Furan-2-carboxylic acid (4-nitro-3-trifluoromethyl-phenyl)-amide 
     2-Chloro-N-(2-chloro-4-nitro-phenyl)-acetamide 
     N-(2-Chloro-4-nitrophenyl)methanesulfonamide 
     Furan-2-carboxylic acid [3-methoxy-4-(2,2,2-trifluoro-acetylamino)-phenyl]-amide 
     N-(2-Chloro-4-nitro-phenyl)-2,2,2-trifluoro-acetamide 
     EXAMPLE 12 
     {4-[(4Phenyl-[1,2,3]thiadiazole-5-carbonyl)-amino]-phenyl }-carbamic acid tert-butyl 
     A solution of 1-(N-tert-butoxycarbonyl)-1,4-phenylenediamine (0.8 g) and 4-phenyl-[1,2,3]thiadiazole-5-carboxylic acid (0.7 g) in dichloromethane (10 mL) is treated with triethylamine (1.3 mL) and benzotriazole-1-yloxy-tris(dimethylamino)-phosphonium hexa-fluorophosphate (1.6 g). After stirring at room temperature, the reaction is diluted with water and extracted with dichloromethane. The organic layer is washed with 0.5 N hydrochloric acid, saturated sodium bicarbonate, and water then dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give the desired product. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     {4-[(1H-Pyrrole-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Pyrazine-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(5-Methyl-thiophene-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(1-Methyl-1H-pyrrole-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Quinoline-8-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Benzofuran-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Isoquinoline-1-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Quinoline-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Pyridine-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(Isoquinoline-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[([1,2,3]Thiadiazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(1H-[1,2,3]Triazole-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [4-(2-Methylsulfanyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4[(Quinoline-4-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(4-Methyl-[1,2,3]thiadiazole-5-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(4-Phenyl-[1,2,3]thiadiazole-5-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[(1H-Indole-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     [1,2,3]Thiadiazole-4-carboxylic acid 4-nitro-benzylamide 
     (4-[([1,2,3]Thiadiazole-4-carbonyl)-amino]-benzyl}-carbamic acid tert-butyl ester 
     Acetic acid 4-(4-tert-butoxycarbonylamino-phenylcarbamoyl)-phenyl ester 
     {4-[(Quinoline-6-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
     EXAMPLE 13 (METHOD 2F) 
     Acetic acid 2-(4-tert-butoxycarbonylamino-2,6-dichloro-phenoxy)-ethyl ester 
     A solution of [3,5-dichloro-4-(2-hydroxy-ethoxy)-phenyl]-carbamic acid tert-butyl ester (0.85 g) in pyridine (14 mL) is treated with acetic anhydride (1.24 mL) and mixture is stirred at room temperature for 15 hours. The solvent is removed under reduced pressure and the residue dissolved in ethyl acetate. This solution is then washed twice with 5% aqueous hydrochloric acid, once with saturated aqueous sodium bicarbonate, and then with saturated aqueous sodium chloride. The solution is dried over anhydrous magnesium sulfate and the solvent is removed under reduced pressure to provide the desired product as a colorless oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     Phenylsulfanyl-acetonitrile 
     Acetic acid 2-(4-tert-butoxycarbonylamino-2,6-dichloro-phenoxy)-ethyl ester 
     EXAMPLE 14 (METHOD 2G) 
     (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester 
     To a solution of 2,6-dichloro-4-amino phenol (9.5 g) in tetrahydrofuran (130 mL) is added di-tert-butyl-dicarbonate (11.7 g) and the mixture is heated to reflux for approximately 15 hours. The solution is then cooled, concentrated under reduced pressure, diluted with ethyl acetate, and washed successively three times with 5% aqueous hydrochloric acid then once with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate then concentrated under reduced pressure to provide the desired crude product. This material is then triturated with cold dichloromethane to provide the product as a white solid. 
     Using the above procedure and appropriate starting materials the following compound was prepared: 
     (3-Amino-5-chloro-phenyl)-carbamic acid tert-butyl ester 
     EXAMPLE 15 (METHOD 3A) 
     3,5-Dichloro-4-ethoxy-phenylamine 
     Trifluoroacetic acid (5 mL) is added to solid (3,5-dichloro-4-ethoxy-phenyl)-carbamic acid tert-butyl ester (0.97 g) and the mixture is stirred for approximately 45 minutes at room temperature. Water is then added, and the mixture is cooled in an ice bath and basified with solid potassium carbonate. The solution is extracted three times with ethyl acetate and the combined organic phases are washed with saturated aqueous sodium chloride then dried over anhydrous sodium sulfate. Concentration under reduced pressure and recrystallization from hexanes provides the desired product as a pale yellow crystalline solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared:ps 
     5-Bromo-pyridin-3-ylamine 
     3-Chloro-4-methanesulfonyl-phenylamine 
     N-(4-Amino-phenyl)-2-methyl-benzamide 
     Acetic acid 2-(4-amino-phenylcarbamoyl)-phenyl ester 
     N-(4-Amino-phenyl)-4-fluoro-benzamide 
     N-(4-Amino-phenyl)-3-fluoro-benzamide 
     N-(4-Amino-phenyl)-2-fluoro-benzamide 
     N-(4-Amino-phenyl)-2-methoxy-benzamide 
     N-(4-Amino-phenyl)-3-methoxy-benzamide 
     N-(4-Amino-phenyl)-4-methoxy-benzamide 
     N-(4-Amino-phenyl)-2-phenyl-acetamide 
     N-(4-Amino-phenyl)-2,2-dimethyl-propionamide 
     N-(4-Amino-phenyl)-2,2,2-trifluoro-acetamide 
     Thiophene-2-carboxylic acid (4-amino-phenyl)-amide 
     1H-Pyrrole-2-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-3-nitro-benzamide 
     3-Acetylamino-N-(4-amino-phenyl)-benzamide 
     N-(4-Amino-phenyl)-3-dimethylamino-benzamide 
     N-(4-Amino-phenyl)-3-methanesulfonylamino-benzamide 
     N-(4-Amino-phenyl)-2-trifluoromethyl-benzamide 
     N-(4-Amino-phenyl)-2,6-difluoro-benzamide 
     N-(4-Amino-phenyl)-2-chloro-benzamide 
     N-(4-Amino-phenyl)-2-bromo-benzamide 
     N-(4-Amino-phenyl)-2-nitro-benzamide 
     Pyrazine-2-carboxylic acid (4-amino-phenyl)-amide 
     5-Methyl-thiophene-2-carboxylic acid (4-amino-phenyl)-amide 
     Quinoline-8-carboxylic acid (4-amino-phenyl)-amide 
     1-Methyl-1H-pyrrole-2-carboxylic acid (4-amino-phenyl)-amide 
     Benzo[b]thiophene-2-carboxylic acid (4-amino-phenyl)-amide 
     Benzofuran-2-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-isonicotinamide 
     Naphthalene-2-carboxylic acid (4-amino-phenyl)-amide 
     Naphthalene-1-carboxylic acid (4-amino-phenyl)-amide 
     Isoquinoline-1-carboxylic acid (4-amino-phenyl)-amide 
     Quinoline-2-carboxylic acid (4-amino-phenyl)-amide 
     3,5-Dichloro-4-ethoxy-phenylamine 
     4-Butoxy-3,5-dichloro-phenylamine 
     Isoquinoline-4-carboxylic acid (4-amino-phenyl)-amide 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-amino-phenyl)-amide 
     1H-[1,2,3]Triazole-4-carboxylic acid (4-amino-phenyl)-amide 
     3-Bromo-thiophene-2-carboxylic acid (4-amino-phenyl)-amide 
     4-Benzyloxy-3,5-dichloro-phenylamine 
     2-(4-Amino-2,6-dichloro-phenoxy)-acetamide 
     (4-Amino-2,6-dichloro-phenoxy)-acetic acid methyl ester 
     [3-(4-Amino-phenylcarbamoyl)-phenyl]-carbamic acid ethyl ester 
     2-Amino-N-(4-amino-phenyl)-benzamide 
     Biphenyl-2-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-2,3-difluoro-benzamide 
     N-(4-Amino-phenyl)-2,5-difluoro-benzamide 
     N-(4-Amino-phenyl)-2,4-difluoro-benzamide 
     2-Acetylamino-N-(4-amino-phenyl)-benzamide 
     N-(4-Amino-phenyl)-2-methanesulfonylamino-benzamide 
     N-(4-Amino-phenyl)-2,3,4-trifluoro-benzamide 
     N-(4-Amino-phenyl)-2,3,4,5,6-pentafluoro-benzamide 
     N-(4-Amino-phenyl)-2-methylsulfanyl-benzamide 
     Acetic acid 2-(4-amino-2,6-dichloro-phenoxy)-ethyl ester 
     N-(4-Amino-phenyl)-isophthalamic acid methyl ester 
     N-(4-Amino-phenyl)-3-benzyloxy-benzamide 
     N-(4-Amino-phenyl)-3-butoxy-benzamide 
     [3-(4-Amino-phenylcarbamoyl)-phenoxy]-acetic acid ethyl ester 
     Pyridine-2-carboxylic acid (4-amino-phenyl)-amide 
     Quinoline-4-carboxylic acid (4-amino-phenyl)-amide 
     5-Methyl-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     5-Difluoromethyl-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     1H-Indole-2-carboxylic acid (4-amino-phenyl)-amide 
     4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid (4-amino-phenyl)-amide 
     Thiophene-3-carboxylic acid (4-amino-phenyl)-amide 
     5-Chloro-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     5-Nitro-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-2-thiophen-2-yl-acetamide 
     3-Methyl-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     5-Bromo-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     4-Bromo-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-nicotinamide 
     N-(4-Aminophenyl)-3-furancarboxamide 
     4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid (4-amino-phenyl)-amide 
     Acetic acid 3-(4-amino-phenylcarbamoyl)-phenyl ester 
     Benzo[1,3]dioxole-4-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-3-(2-dimethylamino-ethoxy)-benzamide 
     N-(4-Amino-phenyl)-3-trifluoromethoxy-benzamide 
     N-(4-Amino-phenyl)-3-(2-morpholin-4-yl-ethoxy)-benzamide 
     (4-Amino-phenyl)-carbamic acid hexyl ester 
     Furan-2-carboxylic acid (4-amino-phenyl)-amide 
     (4-Amino-phenyl)-carbamic acid phenyl ester 
     Hexanoic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-acrylamide 
     N-(4-Amino-phenyl)-2-methoxy-acetamide 
     4-Furan-3-yl-[1,2,3]thiadiazole-5-carboxylic acid (4-amino-phenyl)-amide 
     5-tert-Butyl-furan-2-carboxylic acid (4-amino-phenyl)-amide 
     3-Chloro-4-methanesulfinyl-phenylamine 
     5-Methyl-[1,2,3]thiadiazole-4-carboxylic acid (4-amino-phenyl)-amide 
     2-(4-Amino-2-chloro-phenyl)-ethanol 
     (4-Amino-2-chloro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester 
     5-Chloro-N,N-dimethyl-benzene-1,3-diamine 
     3-(2-Methyl-butyl)-5-trifluoromethyl-phenylamine 
     3-Isobutyl-5-trifluoromethyl-phenylamine 
     Furan-2-carboxylic acid (4-aminomethyl-phenyl)-amide 
     N-(4-Aminomethyl-phenyl)-2-fluoro-benzamide 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-aminomethyl-phenyl)-amide 
     N-(4-Aminomethyl-phenyl)-2,6-difluoro-benzamide 
     Oxazole-4-carboxylic acid (4-amino-phenyl)-amide 
     N-(4-Amino-phenyl)-3-chloro-benzamide 
     N-(4-Amino-phenyl)-4-chloro-benzamide 
     Acetic acid 4-(4-amino-phenylcarbamoyl)-phenyl ester 
     N-(4-Amino-phenyl)-4-dimethylamino-benzamide 
     1-(4-Amino-phenyl)-3-(3,5-bis-trifluoromethyl-phenyl)-thiourea 
     N-(4-Amino-phenyl)-2-iodo-benzamide 
     N-(4-Amino-phenyl)-3-trifluoromethyl-benzamide 
     EXAMPLE 16 (METHOD 3B) 
     1-(4-Amino-2-chloro-phenyl)-ethanol 
     A 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (5.7 mL) is added to [3-chloro-4-(1-hydroxy-ethyl)-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester (0.5 g) and the mixture is stirred at room temperature for approximately 3.5 hours. The solution is then concentrated under reduced pressure, dissolved in a 1:1 mixture of ethyl acetate and hexanes, washed successively with water then saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure followed by chromatography over silica gel (40% ethyl acetate in hexanes is used as the eluant) provides the product as an amber oil. 
     EXAMPLE 17 (METHOD 3C) 
     N-(4-Amino-3-cyanophenyl)-2-fluoro-benzamide 
     Potassium carbonate (5.0 g) is added to a solution of N-[3-cyano-4-(2,2,2-trifluoroacetyl-amino)-phenyl]-2-fluoro-benzamide (2.5 g) in methanol (270 mL) and water (16 mL) and the mixture is refluxed overnight. After removing the solvent under reduced pressure, the residue is suspended in water and extracted with dichloromethane. The organic extracts are pooled, washed with water and then saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to provide the desired compound as a white solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(4-Amino-phenyl)-2-methanesulfinyl-benzamide 
     N-(4-Amino-3-cyano-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-3-cyano-phenyl)-amide 
     N-(4-Amino-3-cyano-phenyl)-acetamide 
     Furan-2-carboxylic acid (4-amino-3-trifluoromethyl-phenyl)-amide 
     N-(4-Amino-3-methoxy-phenyl)-acetamide 
     N-(4-Amino-3-methoxy-phenyl)-2-fluoro-benzamide 
     Furan-2-carboxylic acid (4-amino-3-methoxy-phenyl)-amide 
     EXAMPLE 17 (METHOD 4A) 
     2-Chloro1-cyclohexyloxy-4-nitro-benzene 
     Cylcohexanol (2.9 g) in dimethylsulfoxide (20 mL) is added slowly to a flask containing potassium hydride (0.90 g, pre-washed three times with hexanes) under an atmosphere of argon and the solution is stirred for about 1 hour at room temperature. A solution of 3-chloro-4-fluoro-nitrobenzene (1g) in dimethylsulfoxide (10 mL) is added and the resulting dark red colored solution is then heated for three hours to approximately 100 degrees. The reaction mixture is then cooled, diluted with diethyl ether (300 mL), and washed successively with saturated aqueous ammonium chloride, three times with water, then with saturated aqueous sodium chloride. The organic layer is then dried over anhydrous magnesium sulfate, the solvent is removed under reduced pressure, and the resulting oil is chromatographed over silica gel (5% ethyl acetate in hexanes is used as the eluant) to provide the desired product as an orange solid. 
     EXAMPLE 18 (METHOD 4C) 
     (2-Chloro-4-nitro-phenyl)-methyl-(1-methyl-pyrrolidin-3-yl)-amine 
     3-Chloro-4-fluoronitrobenzene (1.0 g) and N,N′-dimethyl-3-aminopyrrolidine (1.72 g) are combined and stirred for approximately 24 hours. The mixture is then diluted with ethyl acetate, washed twice with water and once with saturated sodium chloride, and dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure the residue is chromatographed over silica gel (pure ethyl acetate followed by pure methanol is used as the eluants) to provide the desired product as a yellow oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     (2-Chloro-4-nitro-phenyl)-dipropyl-amine 
     1-(2-Chloro-4-nitro-phenyl)-piperidine 
     1-(2-Chloro-4-nitro-phenyl)-pyrrolidine 
     (2-Chloro-4-nitro-phenyl)-cyclohexyl-methyl-amine 
     Benzyl-(2-chloro-4-nitro-phenyl)-amine 
     (2-Chloro-4-nitro-phenyl)-methyl-(1-methyl-piperidin-4-yl)-amine 
     (2-Chloro-4-nitro-phenyl)-cyclohexyl-ethyl-amine 
     (2-Chloro-4-nitro-phenyl)-cyclohexyl-amine 
     (2-Chloro-4-nitro-phenyl)-methyl-(1-methyl-pyrrolidin-3-yl)-amine 
     (1-Benzyl-pyrrolidin-3-yl)-(2-chloro-4-nitro-phenyl)-methyl-amine 
     (2-Chloro-4-nitro-phenyl)-cyclopentyl-methyl-amine 
     1-(2-Chloro-4-nitro-phenyl)-decahydro-quinoline 
     Allyl-(2-chloro-4-nitro-phenyl)-cyclohexyl-amine 
     2-[(2-Chloro-4-nitro-phenyl)-(2-hydroxy-ethyl)-amino]-ethanol 
     (2-Chloro-4-nitro-phenyl)-isobutyl-methyl-amine 
     (2-Chloro-4-nitro-phenyl)-hexyl-methyl-amine 
     2-[(2-Chloro-4-nitro-phenyl)-methyl-amino]-ethanol 
     N-(2-Chloro-4-nitro-phenyl)-N,N′,N′-trimethyl-ethane-1,2-diamine 
     N-(2-Chloro-4-nitro-phenyl)-N,N′,N′-trimethyl-propane-1,3-diamine 
     (1-Benzyl-piperidin-4-yl)-(2-chloro-4-nitro-phenyl)-amine 
     N-(2-Chloro-4-nitro-phenyl)-N′,N′-dimethyl-ethane-1,2-diamine 
     N-(2-Chloro-4-nitro-phenyl)-N′,N′-dimethyl-propane-1,3-diamine 
     (2-Chloro-4-nitro-phenyl)-(2-methoxy-ethyl)-methyl-amine 
     (1-Benzyl-pyrrolidin-3-yl)-(2-chloro-4-nitro-phenyl)-amine 
     4-Piperidin-1-yl-3-trifluoromethyl-benzonitrile 
     4-Dimethylamino-3-trifluoromethyl-benzonitrile 
     4-(4-Methyl-piperazin-1-yl)-3-trifluoromethyl-benzonitrile 
     EXAMPLE 19 (METHOD 4E) 
     Butyl-(2-chloro-4-nitro-phenyl)thioether 
     A solution of 3-chloro-4-fluoro-nitrobenzene (5.0 g) and sodium sulfide (2.5 g) in N,N-dimethylformamide (30 mL) is stirred at room temperature for 1 hour and then treated with 1-iodobutane (12.6 g). The solvent is then removed under reduced pressure and the resulting residue is treated with ethyl acetate and hexanes to precipitate the inorganic salts. The solids are removed by filtration and the filtrate is reduced under reduced pressure. The resulting residue is then passed through hydrous magnesium silicate using dichloromethane as the eluent to provide the desired compound as a yellow solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     1-Butylsulfanyl-2-chloro-4-nitro-benzene 
     2-Chloro-1-cyclohexylsulfanyl-4-nitro-benzene 
     2-Chloro-1-ethylsulfanyl-4-nitro-benzene 
     EXAMPLE 20 (METHOD 4F) 
     (4-Chloro-5-methoxy-2-nitro-phenyl)-dimethyl-amine 
     To a solution of trifluoro-methanesulfonic acid 4-chloro-5-methoxy-2-nitro-phenyl ester (1.0 g) in tetrahydrofuran (2.0 mL) is added dimethylamine (4.0 mL of a 40% aqueous solution) and the mixture is stirred at room temperature for approximately 15 hours. The solution is then concentrated under reduced pressure and the residue is dissolved in ethyl acetate and then washed with water. The aqueous layer is extracted once with ethyl acetate and the combined organic layers are washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with hexanes to provide the desired product as a colorless solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     (4-Chloro-2-nitro-phenyl)-dimethyl-amine 
     4-(4-Chloro-5-methoxy-2-nitro-phenyl)-morpholine 
     4-Chloro-5-methoxy-2-nitro-phenyl)-dimethyl-amine 
     1-(4-Chloro-5-methoxy-2-nitro-phenyl)-piperidine 
     1-(4-Chloro-5-methoxy-2-nitro-phenyl)-pyrrolidine 
     Benzyl-(4-chloro-5-methoxy-2-nitro-phenyl)-amine (2-Chloro-6-nitro-phenyl)-dimethyl-amine 
     EXAMPLE 21 (METHOD 4G) 
     (2-Chloro-4-nitro-phenyl)-methyl-phenyl-amine 
     n-Butyl lithium (12.3 mL of a 2.5 M solution in hexanes) is added dropwise to a solution of N-methyl aniline (3.0 g) in tetrahydrofuran (75 mL) at 0° C. The mixture is allowed to warm slowly to room temperature and is then re-cooled to 0° C. and added by cannula to a solution of 3-chloro-4-fluoronitrobenzene (4.9 g) in tetrahydrofuran (35 mL) that is kept at −78° C. Following the addition, the reaction mixture is permitted to warm to room temperature over the course of 1 hour, and is then concentrated under reduced pressure, quenched by addition of saturated aqueous ammonium chloride, and extracted three times with ethyl acetate. The pooled organic layers are washed three times with 5% aqueous hydrochloric acid, once with water, once with saturated aqueous sodium bicarbonate, once with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. Following removal of the solvent under reduced pressure the residue is chromatographed over silica gel (5% diethyl ether in hexanes is used as the eluant) to provide the desired product as a clear colorless oil. 
     EXAMPLE 22 (METHOD 4H) 
     2,6-Dichloro-4-nitrophenol 
     3,4,5-Trichloronitrobenzene (14.86 g) is added to a solution of potassium phenoxide (8.66 g) in diethylene glycol (66 mL) and the mixture is heated to 160° C. for approximately 15 hours. The resulting dark brown solution is cooled to room temperature, poured onto 100 mL cold water, and extracted twice with diethyl ether. The pooled organic extracts are washed with water, 10% aqueous sodium hydroxide, and then dried over anhydrous magnesium sulfate. Following removal of the solvent under reduced pressure the resulting oil is distilled in a Kugelrohr apparatus to provide a yellow oil that solidifies on standing. Recrystallization from ethanol-water provides the desired product as a pale yellow solid. 
     EXAMPLE 23 (METHOD 5A) 
     (3,5-Dichloro-4ethoxy-phenyl)-carbamic acid tert-butyl ester 
     To a solution of (3,5-dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester (1.0 g) and potassium carbonate (1.0 g) in acetone (18 mL) is added ethyl iodide (0.36 mL) and the mixture is stirred for approximately 15 hours at room temperature. The solution is then filtered, concentrated under reduced pressure, and partitioned between ethyl acetate and water. The separated aqueous layer is further extracted twice with ethyl acetate, and the pooled organic extracts are washed successively with 10% aqueous sodium hydroxide, with water, and then dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave the desired product as a tan solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     (3,5-Dichloro-4-ethoxy-phenyl)-carbamic acid tert-butyl ester 
     (4-Butoxy-3,5-dichloro-phenyl)-carbamic acid tert-butyl ester 
     (4-Benzyloxy-3,5-dichloro-phenyl)-carbamic acid tert-butyl ester 
     (4-Carbamoylmethoxy-3,5-dichloro-phenyl)-carbamic acid tert-butyl ester 
     [3,5-Dichloro-4-(2-nitrilo-ethoxy)-phenyl]-carbamic acid tert-butyl ester 
     (4-tert-Butoxycarbonylamino-2,6-dichloro-phenoxy)-acetic acid methyl ester 
     3-Butoxy-benzoic acid methyl ester 
     3-tert-Butoxycarbonylmethoxy-benzoic acid methyl ester 
     3-Carbamoylmethoxy-benzoic acid methyl ester 
     [4-(3-Carbamoylmethoxy-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[3-(2-Chloro-ethoxy)-benzoylamino]-phenyl}-carbamic acid tert-butyl ester 
     EXAMPLE 24 (METHOD 5C) 
     (2,6-Dichloro-4-nitro-phenoxy)-acetic acid tert-butyl ester 
     To a solution of 2,6-dichloro-4-nitrophenol (2.5 g) and potassium carbonate (3.3 g) in dimethyl-formamide (50 mL) is added tert-butyl-bromoacetate (10 mL) and the mixture is stirred at room temperature for two days. The solution is then poured into 500 mL water, extracted three times with hexanes, and the pooled organic extracts are washed with saturated aqueous ammonium chloride and then dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure followed by trituration of the resulting oil with hexanes provides the desired product as a white solid. 
     Using the above procedure and starting materials the following compounds were prepared: 
     3-Dimethylamino-1-(4-nitro-phenyl)-propenone 
     2-Chloro-1-isopropoxy-4-nitro-benzene 
     1,3-Dichloro-2-methoxy-4-methyl-5-nitro-benzene 
     1-Chloro-4-ethoxy-2-methoxy-5-nitro-benzene 
     1-Butoxy-4-chloro-5-methoxy-2-nitro-benzene 
     1-Chloro-2-methoxy-5-nitro-4-(phenylmethoxy)benzene (CA name) 
     1-Chloro-4-methoxy-5-nitro-2-(phenylmethoxy)benzene (CA name) 
     (2,6-Dichloro-4-nitro-phenoxy)-acetic acid tert-butyl ester 
     (2,6-Dichloro-4-nitro-phenoxy)-acetonitrile 
     1-Chloro-4-methoxy-2-methyl-5-nitro-benzene 
     2-(4-Chloro-5-methoxy-2-nitro-phenoxy)-acetamide 
     2-(2-Chloro-5-methoxy-4-nitro-phenoxy)-acetamide 
     (4-Chloro-5-methoxy-2-nitro-phenoxy)-acetonitrile 
     (2-Chloro-5-methoxy-4-nitro-phenoxy)-acetonitrile 
     4-(2-Chloro-5-methoxy-4-nitro-phenoxy)-butyronitrile 
     2-(4-Chloro-5-methoxy-2-nitro-phenoxy)-ethanol 
     2-(2-Chloro-5-methoxy-4-nitro-phenoxy)-ethanol 
     (2-Chloro-5-methoxy-4-nitro-phenoxy)-acetic acid tert-butyl ester 
     (2-Chloro-5-methoxy-4-nitro-phenoxy)-acetic acid methyl ester 
     (4-Chloro-5-methoxy-2-nitro-phenoxy)-acetic acid methyl ester 
     (4-Chloro-5-methoxy-2-nitro-phenoxy)-acetic acid tert-butyl ester 
     (2-Chloro-4-nitro-phenoxy)-acetonitrile 
     1-Butoxy-2-chloro-4-nitro-benzene 
     2-Chloro-4-nitro-1-(2,2,2-trifluoro-ethoxy)-benzene 
     2-Chloro-4-nitro-1-propoxy-benzene 
     2-Chloro-1-ethoxy-4-nitro-benzene 
     1,3-Diiodo-2,4-dimethoxy-5-nitro-benzene 
     1,3-Dibromo-2,4-dimethoxy-5-nitro-benzene 
     3-Chloro-2,4-dimethoxy-nitro-benzene 
     EXAMPLE 25 (METHOD 5E) 
     [3,5-Dichloro-4-(2-hydroxy-ethoxy)-phenyl]-carbamic acid tert-butyl ester 
     To a solution of (3,5-dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester (1.0 g) and potassium carbonate (0.55 g) in toluene (20 mL) is added ethylene carbonate (1.6 g) and the mixture is heated to reflux for 3 hours. To the cooled reaction mixture is added 2.5 M aqueous sodium hydroxide (50 mL), and the separated organic layer is then washed successively with water, then saturated aqueous sodium chloride, and then dried over anhydrous sodium sulfate. The solvent is then removed by evaporation under reduced pressure and the resulting residue is chromatographed over silica gel (30% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a white foam. 
     EXAMPLE 26 (METHOD 6) 
     3-(2-Chloro-4-nitro-phenoxy)-1-methyl-pyrrolidine 
     To a solution of 2-chloro-4-nitrophenol (2.0 g) in tetrahydrofuran (60 mL) is added 1-methyl-3-pyrrolidinol (2.3 g), triphenyl phosphine (6.0 g), and diethylazodicarboxylate (3.6 mL) and the mixture is stirred at room temperature under an atmosphere of argon for 1.5 hours. The solution is then concentrated under reduced pressure, diluted with ethyl acetate, washed successively with 10% aqueous sodium hydroxide, water, saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is chromatographed over silica gel (ethyl acetate then 10% methanol in dichloromethane is used as the eluant). Pooled product fractions are then recrystallized from hexanes to provide the desired product as a yellow solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     4-(2-Chloro-4-nitro-phenoxy)-1-methyl-piperidine 
     3-(2-Chloro-4-nitro-phenoxy)-1-methyl-pyrrolidine 
     [2-(2-Chloro-4-nitro-phenoxy)-ethyl]-dimethyl-amine 
     [3-(2-Chloro-4-nitro-phenoxy)-propyl]-dimethyl-amine 
     EXAMPLE 27 (METHOD 7A) 
     2-Chloro-3-methoxy-6-nitro-phenol and 2,4-Dichloro-3-methoxy-6-nitro-phenol 
     To a flask containing 3-methoxy-6-nitro-phenol (0.5 g) is added aqueous sodium hypochlorite (5.25% aqueous solution, 21 mL) and the mixture is stirred at room temperature for approximately 24 hours. The mixture is then cooled in an ice-bath, acidified by addition of concentrated hydrochloric acid, then extracted twice with ethyl acetate. These organic extracts are dried over anhydrous magnesium sulfate, the solvent is removed by evaporation under reduced pressure, and the residue is chromatographed over silca gel (15% acetone in hexanes is used as the eluant) to provide both the mono- and di-chlorinated products as yellow solids. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     3-Chloro-2-hydroxy-4-methoxy-nitrobenzene 
     3,5-Dichloro-2-hydroxy-4-methoxy-nitrobenzene 
     EXAMPLE 28 (METHOD 7B) 
     2,4-Dichloro-3-methyl-6-nitro-phenol 
     To a solution of 3-methyl-4-nitro-phenol (5.0 g) in water (150 mL) is added aqueous sodium hypochlorite (5.25% aqueous solution, 230 mL) and the mixture is stirred at room temperature for approximately 15 hours. Additional aqueous sodium hypochlorite (5.25% aqueous solution, 230 mL) is added and the mixture is permitted to stir at room temperature for 2.5 days. The mixture is then cooled in an ice-bath, acidified by addition of concentrated hydrochloric acid, then extracted twice with ethyl acetate. These organic extracts are dried over anhydrous magnesium sulfate, the solvent is removed by evaporation under reduced pressure, and the residue is chromatographed over silca gel (ethyl acetate is used as the eluant) to provide the desired product as a yellow solid. An analytically pure sample is obtained by a single recrystallization from chloroform. 
     EXAMPLE 29 (METHOD 7C) 
     1-Bromo-2,4-dimethoxy-5-nitro-benzene 
     To a solution of 2,4-dimethoxy-nitrobenzene (0.50 g) in chloroform (3 mL) is added dropwise a solution of bromine (0.23 g) in chloroform (1 mL) and the mixture is allowed to stir at room temperature for approximately 15 hours. Additional bromine (0.15 g) in chloroform (1 mL) is added and the reaction is stirred for an additional 4 hours. The mixture is then poured onto 5% aqueous sodium bisulfite and then extracted with chloroform. Pooled organic extracts are then washed successively with 5% aqueous sodium bisulfite then saturated sodium chloride, and then dried over anhydrous sodium sulfate. Removal of the solvent under reduced pressure and recrystallization of the residue from toluene provides the desired product as a yellow solid. 
     EXAMPLE 30 (METHOD 7D) 
     2,4-Dibromo-3-methoxy-6-nitro-phenol 
     To a solution of 5-methoxy-2-nitro-phenol (0.25 g) and silver trifluoroacetate (0.49 g) in glacial acetic acid (3 mL) is added dropwise a solution of bromine (1.42 g) in glacial acetic acid (3 mL) and the mixture is stirred at room temperature for approximately 24 hours. The solution is then partitioned between ethyl acetate and water, and the organic layer is washed successively three times with 5% aqueous sodium bisulfite, three times with saturated aqueous sodium bicarbonate, and once with saturated aqueous sodium chloride. The organic layer is then dried over anhydrous magnesium sulfate and the solvent is removed under reduced pressure. The residue is chromatographed over silica gel (20% ethyl acetate in hexanes is used as the eluant) then recrystallized from chloroform to provide the desired dibrominated product as an orange solid. 
     EXAMPLE 31 (METHOD 7E) 
     1-Iodo-2,4-dimethoxy-5-nitro-benzene 
     To a solution of 2,4-dimethoxy-nitrobenzene (1.0 g) in glacial acetic acid (30 mL) is added benzyltrimethylammonium dichloroiodate (1.90 g) and anhydrous zinc chloride (1.0 g) and the mixture is stirred at room temperature under an atmosphere of argon. Additional benzyltrimethylammonium dichloroiodate (0.4 g) is added after 5 hours and again after 24 hours. Additional zinc chloride (0.5 g) and glacial acetic acid (15 mL) is added after 24 hours. The mixture is permitted to stir at room temperature for 3 days and is then filtered, diluted with 5% aqueous sodium bisulfite, and extracted three times with ethyl acetate. These pooled organic extracts are washed successively with 5% aqueous sodium bisulfite, saturated aqueous sodium chloride, then dried over anhydrous magnesium sulfate. 
     After removal of the solvent under reduced pressure the residue is triturated with hexanes to provide the desired product as a pale yellow solid. 
     EXAMPLE 32 (METHOD 7F) 
     2,4-Diiodo-3-methoxy-6-nitro-phenol 
     To a solution of 5-methoxy-2-nitro-phenol (0.25 g) in dichloromethane (15 mL) and methanol (6 mL) is added benzyltrimethylammonium dichloroiodate (1.08 g) and sodium bicarbonate (0.85 g) and the mixture is allowed to stir at room temperature for 24 hours. The solution is then filtered, the filtrate is concentrated under reduced pressure, the residue is dissolved in ethyl acetate and then washed successively with 5% aqueous sodium bicarbonate, 5% aqueous sodium bisulfite, and saturated aqueous sodium chloride. After drying over anhydrous magnesium sulfate the solvent is removed by evaporation under reduced pressure and the residue is recrystallized from toluene to provide the desired product as yellow needles. 
     EXAMPLE 33 (METHOD 7G) 
     1-Fluoro-2,4dimethoxy-5-nitro-benzene 
     To a solution of 2,4-dimethoxy-nitrobenzene (1.0 g) in tetrachloroethane (10 mL) is added 3,5-dichloro-1-fluoro-pyridinium triflate (85%, 5.07 g) and the mixture is heated to 120° C. for 5 hours. Additional 3,5-dichloro-1-fluoro-pyridinium triflate (85%, 0.25 g) is added and heating is continued for 1 hour. The solution is then cooled to room temperature and passed over a column of silica gel (hexanes followed by 30% ethyl acetate in hexanes is used as the eluant). Product containing fractions are combined, evaporated under reduced pressure, and the residue is crystallized from hexanes to provide the desired product as a tan solid. 
     EXAMPLE 34 (METHOD 8) 
     3-Chloro-4-trifluoromethyl-nitrobenzene 
     A solution of 3-chloro-4-iodo-nitrobenzene (2.26 g), trimethyl(trifluoromethyl)silane (5.68 g), copper(I) iodide (2.28 g), and potassium fluoride (0.56 g) in N,N-dimethylformamide (8 mL) is heated in a sealed tube to 80° C. for 40 hours. The solution is then cooled, diluted with diethyl ether, filtered through diatomaceous earth, and the filtrate is washed successively with water, saturated aqueous sodium chloride, and then dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure and the residue is chromatographed over silica gel (1% diethyl ether in hexanes followed by 10% ethyl acetate in hexanes is used as the eluant) to provided the desired product as a colorless oil. 
     EXAMPLE 35 (METHOD 9) 
     (3-Chloro-4methanesulfinyl-phenyl)-carbamic acid tert-butyl ester 
     To a solution of (3-chloro-4-thiomethyl-phenyl)-carbamic acid tert-butyl ester (0.89 g) in dichloromethane (15 mL) at 0° C. is added a solution of dimethyldioxirane (˜0.11 M in acetone, 34 mL) and the mixture is stirred at 0° C. for 1 hour. The solvent is removed under reduced pressure and the residue is dissolved in dichloromethane, washed with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. Removal of the solvent-under reduced pressure gave the desired product as an orange foam. 
     EXAMPLE 36 (METHOD 9B) 
     [4-(2-Methylsulfinyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     To a solution of 2-methylsulfanyl-N-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-benzamide (234 mg) is added a saturated solution of sodium periodate (5 mL) and the mixture is stirred for 12 hours. The purple mixture is poured into water, extracted with ethyl acetate, dried over anhydrous potassium carbonate and evaporated to yield a red solid, 101 mg. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     [4-(2-Methanesulfinyl-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     2-Methanesulfinyl-N-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-benzamide 
     EXAMPLE 37 (METHOD 10) 
     (3-Chloro-4methanesulfonyl-phenyl)-carbamic acid tert-butyl ester 
     To a solution of (3-chloro-4-thiomethyl-phenyl)-carbamic acid tert-butyl ester (0.90 g) in dichloromethane (30 mL) at 0° C. is added a solution of dimethyldioxirane (˜0.11 M in acetone, 80 mL) and the mixture is stirred at 0° C. for 1 hour. The solvent is removed under reduced pressure and the residue is dissolved in dichloromethane, washed with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gives the desired product as an orange foam. 
     EXAMPLE 38 (METHOD 11) 
     3-Chloro-4-vinyl-phenylamine 
     To a deoxygenated solution of 3-chloro-4-iodo-aniline (6.95 g), triphenyl arsine (0.67 g), and tris(dibenzylideneacetone)palladium(0) (0.50 g) in tetrahydrofuran (120 mL) at 50° C. is added tributylvinyltin (10 g) and the mixture is stirred for approximately 15 hours at 50° C. under an atmosphere of argon. The reaction is then cooled, filtered through diatomaceous earth, and the filtrate is evaporated to dryness under reduced pressure. The residue is dissolved in hexanes and then extracted three times with 5% aqueous hydrochloric acid. These aqueous acidic extracts are then basified with solid potassium carbonate and extracted three times with ethyl acetate. These pooled organic extracts are then washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and the solvent is removed under reduced pressure. The resulting residue is chromatographed over silica gel (hexanes and then 10% ethyl acetate in hexanes is used as the eluant) to provide the desired product as an amber oil. 
     EXAMPLE 39 (METHOD 12) 
     [3-Chloro-4-(1-hydroxy-ethyl)-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 
     (3-Chloro-4-vinyl-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester (2.6 g) is added to a solution of mercuric acetate (3.48 g) in water (7 mL) and tetrahydrofuran (5.25 mL) and the mixture is stirred for approximately 15 hours. 3N Aqueous sodium hydroxide (8.7 mL) and a 0.5 M solution of sodium borohydride in 3N aqueous sodium hydroxide (8.7 mL) are then added and stirring is continued for 6 hours. The solution is then saturated with sodium chloride and extracted with ethyl acetate. These organic extracts are then washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. Following removal of the solvent under reduced pressure the residue is chromatographed over silica gel (20% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a white solid. 
     EXAMPLE 40 (METHOD 13) 
     [3-Chloro-4-(2-hydroxy-ethyl)-phenyl]-carbamic acid tert-butyl ester 
     To a stirring suspension of sodium borohydride (0.45 g) in tetrahydrofuran (13 mL) at 0° C. is added glacial acetic acid (0.75 mL) and the mixture is stirred at 0° C. for 1 hour. The solution is then warmed to room temperature and (3-chloro-4-vinyl-phenyl)-carbamic acid 2-trimethylsilanyl-ethyl ester (1.0 g) is added. The reaction is stirred at room temperature for approximately 15 hours and then heated to reflux for approximately 20 hours. The mixture is then cooled and solutions of 5 N aqueous sodium hydroxide (0.80 mL) and 30% aqueous hydrogen peroxide (0.56 mL) are added. After stirring for an additional 15 hours the layers are separated, the aqueous layer is extracted three times with diethyl ether, and these organic extracts are dried over anhydrous magnesium sulfate. Following removal of the solvent under reduced pressure the residue is chromatographed over silica gel (40% ethyl acetate in hexanes is used as the eluant) to provide the desired product as an amber oil. 
     EXAMPLE 41 (METHOD 14) 
     [4(1-Azido-ethyl)-3-chloro-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester 
     To a solution of [3-chloro-4-(1-hydroxy-ethyl)-phenyl]-carbamic acid 2-trimethylsilanyl-ethyl ester (1.25 g) in tetrahydrofuran (20 mL) at 0° C. under an atmosphere of argon is added triphenyl-phosphine (2.6 g), hydrazoic acid (approximately 2.5 molar equivalents in dichloromethane, prepared by the method of Fieser and Fieser,  Reagents for Organic Synthesis , Vol. 1, pg. 446; Wiley, New York) and diethyl azodicarboxylate (1.72 g). After approximately 10 minutes the solvent is removed under reduced pressure and the residue is chromatographed over silica gel (5% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a colorless oil. 
     EXAMPLE 42 (METHOD 15) 
     [3-Chloro-4-(3-dimethylamino-prop-1-ynyl)-phenyl]-carbamic acid tert-butyl ester 
     To a deoxygenated solution of (3-chloro-4-iodo-phenyl)-carbamic acid tert-butyl ester (10.0 g) in triethylamine (120 ml) is added 1-dimethylamino-2-propyne (2.82 g), bis(triphenyl-phosphine)palladium(II) chloride (0.4 g), and cuprous iodide (0.054 g). The mixture is stirred at room temperature under an atmosphere of argon for approximately 6 hours and is then heated briefly (ca. 10 minutes) to 60° C. The reaction mixture is then cooled, filtered through diatomaceous earth, and the solvent is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate, washed three times with water, once with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure, and the residue is chromatographed over silica gel (80% ethyl acetate in hexanes is used as the eluant) to give the purified product as an amber oil that solidified on standing. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     [3-Chloro-4-(3-dimethylamino-prop-1-ynyl)-phenyl]-carbamic acid tert-butyl ester [3-(4-Methoxy-phenyl)-prop-2-ynyl]-dimethyl-amine 
     4-(3-Dimethylamino-prop-1-ynyl)-benzonitrile 
     Dimethyl-[3-(4-nitro-phenyl)-prop-2-ynyl]-amine 
     EXAMPLE 43 (METHOD 16) 
     (3-Chloro-4-(3-dimethylamino-acryloyl)-phenyl]-carbamic acid tert-butyl ester 
     To an ice cold solution of [3-chloro-4-(3-dimethylamino-prop-1-ynyl)-phenyl]-carbamic acid tert-butyl ester (4.0 g) in dichloromethane (30 ml) is added in small portions 3-chloroperoxybenzoic acid (2.34 g). After the reaction is stirred at 0° C. for 20 minutes, the mixture is passed over twenty weight equivalents of basic alumina (Brockmann Grade I, 150 mesh) and the N-oxide is eluted using a solution of 5% methanol in dichloromethane. All fractions containing the desired amine N-oxide were combined and evaporated to near dryness under reduced pressure. The residue is treated successively three times with small portions of methanol (ca. 50 ml) followed by evaporation to near dryness under reduced pressure, and the volume of the solution is adjusted to 250 mL by addition of methanol. The methanolic solution of the N-oxide is then heated to reflux for approximately 15 hours, then cooled, and the solvent is evaporated to dryness under reduced pressure. The residue is purified by chromatography over silica gel (80% ethyl acetate in hexanes is used as the eluant) to give the desired product as a pale yellow solid. 
     EXAMPLE 44 (METHOD 17) 
     (3-Chloro-4-isoxazol-5-yl-phenyl)-carbamic acid tert-butyl ester 
     A solution of [3-chloro-4-(3-dimethylamino-acryloyl)-phenyl]-carbamic acid tert-butyl ester (270 mg) in dioxane (3 ml) is treated with hydroxylamine hydrochloride (122 mg) and the mixture is stirred at room temperature for 10 days. The mixture is diluted with ethyl acetate, washed successively with water, 5% aqueous sodium bicarbonate, saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is chromatographed over silica gel (33% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a colorless solid. 
     EXAMPLE 45 (METHOD 18) 
     [3-Chloro-4-(1H-pyrazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 
     A solution of [3-chloro-4-(3-dimethylamino-acryloyl)-phenyl]-carbamic acid tert-butyl ester (250 mg) in ethanol (1.25 ml) is treated with hydrazine hydrate (0.25 ml) and the mixture is stirred at room temperature for 3 hours. The mixture is then diluted with 30 mL of diethyl ether, washed three times with water, once with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is chromatographed over silica gel (67% ethyl acetate in hexanes is used as the eluant) to provide the desired product as an oil. 
     EXAMPLE 46 (METHOD 19A) 
     N-(2-Chloro-4-nitrophenyl)-2-thiomorpholino-4-yl-acetamide 
     To a solution N-(chloroacetyl)-2-chloro-4-nitroaniline (3.80 g) in tetrahydrofuran (50 mL) is added thiomorpholine (10 mL) and the solution allowed to stand for 1 hour. This reaction mixture is poured into water a pale yellow solid is collected and then recrystallized from hot 2-propanol to give a pale yellow crystalline solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     (4-{2-[Bis-(2-hydroxy-ethyl)-amino]-acetylamino)-phenyl)-carbamic acid tert-butyl ester 
     [4-(2-Dimethylamino-acetylamino)-phenyl]-carbamic acid tert-butyl ester 
     {4-[3-(2-Dimethylamino-ethoxy)-benzoylamino]-phenyl}-carbamic acid tert-butyl ester 
     {4-[3-(2-Morpholin-4-yl-ethoxy)-benzoylamino]-phenyl}-carbamic acid tert-butyl ester 
     N-(2-Chloro-4-nitro-phenyl)-2-dimethylamino-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-piperidin-1-yl-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-morpholin-4-yl-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-dipropylamino-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-thiomorpholin-4-yl-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-diethylamino-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-pyrrolidin-1-yl-acetamide 
     2-Azepan-1-yl-N-(2-chloro-4-nitro-phenyl)-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-(2-methyl-piperidin-1-yl)-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-(3-methyl-piperidin-1-yl)-acetamide 
     N-(2-Chloro-4-nitro-phenyl)-2-(4-methyl-piperidin-1-yl)-acetamide 
     EXAMPLE 47 (METHOD 19B) 
     N-(2-Chloro-4-nitrophenyl)-2-(2-dimethylaminoethylsulfanyl)acetamide 
     To a solution of N-(chloroacetyl)-2-chloro-4-nitroaniline (3.01 g) in N,N-dimethylformamide (100 mL) is added powdered sodium carbonate (6.0 g) and 2-dimethylaminoethanethiol hydrochloride (6.0 g). The mixture is stirred for 1 hour at 25° C., poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous potassium carbonate and concentrated under reduced pressure to give an oil. The oil is crystallized from toluene-hexanes (3:1) to yield a pale yellow crystalline solid. 
     EXAMPLE 48 (METHOD 20) 
     (4-tert-butoxycarbonylamino-2-chloro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester 
     To a suspension of 1,1-carbonyl-di-(1,2,4)-triazole (4.0 g) in dichloromethane (40 mL) is added a solution of (4-amino-3-chloro-phenyl) carbamic acid tert-butyl ester (5.0 g) in dichloromethane (45 mL) dropwise over 20 minutes. The reaction is stirred at room temperature for 30 minutes at which point a precipitate forms. To this mixture is added piperidineethanol (6.6 mL) and tetra-hydrofuran (20 mL) is added to maintain homogeneity. After heating at reflux overnight the reaction is cooled and then poured into water, the organic layer separated and then washed with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to a crude oil that is purified by chromatography over silica gel (5% methanol in dichloromethane is used as the eluant) to give the desired product as a white foam. 
     EXAMPLE 49 (METHOD 21) 
     5-Phenyl-[1,2,3]thiadiazole-4-carboxylic acid methyl ester 
     A solution of ethyl benzoylacetate (1.1 g) in acetonitrile (10 mL) is treated with 4-methylbenzenesulfonyl azide (1.3 g) and triethylamine (1.6 g). After stirring overnight at room temperature, the reaction is concentrated under reduced pressure and the resulting crude product is dissolved in ethyl acetate and washed with 1N sodium hydroxide. The organic layer is then dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to yield a yellow oil. 
     This oil is taken into dichloromethane and filtered through a pad of hydrous magnesium silicate, eluting with dichloromethane to give the partially purified diazoketone as a colorless oil. A sample of the diazoketone from above (1.2 g) is dissolved in toluene (25 mL) and treated with 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide (2.8 g) and the reaction is heated to reflux. After 3 hours, the reaction is cooled to room temperature, loaded onto a pad of silica gel and eluted with dichloromethane. After removing the solvent under reduced pressure, the resulting oil is purified by chromatography over silica gel (30% diethyl ether in petroleum ether is used as the eluant) and then recrystallized from hexanes to give the desired product as pale yellow needles. 
     Using the above procedure and appropriate starting materials the following compound was prepared: 
     5-Phenyl-[1,2,3]thiadiazole-4-carboxylic acid ethyl ester 
     5-Methyl-[1,2,3]thiadiazole-4-carboxylic acid methyl ester 
     EXAMPLE 50 
     Ethyl benzoylacetate semicarbazide 
     Ethyl benzoylacetate (5.0 g) is dissolved in methanol (10 mL) and added rapidly to a hot solution of semicarbazide hydrochloride (29 g) in water (130 mL). To this is added pyridine (4.1 g) and after heating to reflux for 5 minutes, the reaction mixture is cooled to −20° C. overnight. The resulting solid semicarbazone is collected by filtration, washed with water and then diethyl ether to give the desired product as white crystals. 
     Using the above procedure and appropriate starting materials the following compound was prepared: 
     Ethyl (Z)-3-[(aminocarbonyl)hydrazono]-4,4,4-trifluorobutanoate 
     3-[(Z)-2-(Aminocarbonyl)hydrazono]-3-phenylpropanoic acid ethyl ester 
     3-[(E)-2-(Aminocarbonyl)hydrazono]-3-(3-furyl)propanoic acid ethyl ster 
     EXAMPLE 51 
     5-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid ethyl ester 
     A solution of ethyl benzoylacetate semicarbazone (2.5 g) in neat thionyl chloride (5 mL) is stirred at 0° C. for 1 hour. Dichloromethane is then added (25 mL), the excess thionyl chloride is destroyed slowly with saturated aqueous sodium bicarbonate. The precipitate which forms on quenching is removed by filtration and the filtrate is extracted with dichloromethane. Pooled organic extracts are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Chromatography over silica gel (50% hexanes in dichloromethane is used as the eluant) affords the desired product as a colorless oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid methyl ester 
     4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid ethyl ester 
     4-Furan-3-yl-[1,2,3]thiadiazole-5-carboxylic acid ethyl ester 
     EXAMPLE 52 
     4Methyl-[1,2,3]thiadiazole-5-carboxylic acid 
     4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid methyl ester (1.7 g) is dissolved in methanol (15 mL) and treated with 1N sodium hydroxide (16 mL). After stirring at room temperature for 1 hour, the reaction is treated with concentrated hydrochloric acid (1.5 mL) and concentrated under reduced pressure. The resulting turbid aqueous layer is extracted twice with diethyl ether and the pooled organic layers are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the desired compound as a white powder. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     3-Ethoxycarbonylmethoxy-benzoic acid 
     5-Furan-3-yl-[1,2,3]thiadiazole-4-carboxylic acid 
     Thiazole-4-carboxylic acid 
     4-Methyl-[1,2,3]thiadiazole-5-carboxylic acid 
     5-Methyl-[1,2,3]thiadiazole-4-carboxylic acid 
     EXAMPLE 53 (METHOD 25) 
     Trifluoro-methanesulfonic acid 4chloro-5-methoxy-2-nitro-phenyl ester 
     To a solution of 4-chloro-5-methoxy-2-nitro-phenol (6.5 g) in dichloromethane (150 mL) at 0° C. under an atmosphere of argon is added triethylamine (10 g) and then a solution of trifluoro-methanesulfonic anhydride (13.5 g) in dichloromethane (30 mL). The solution is stirred at 0° C. for 10 minutes, and is then diluted with dichloromethane and washed successively with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate the solvent is removed by evaporation under reduced pressure and the residue is dissolved in a solution of 20% dichloromethane in hexanes and passed through a short column of hydrous magnesium silicate (20% dichloromethane in hexanes is used as the eluant). Product containing fractions are pooled and the solvents removed by evaporation under reduced pressure to give the desired product as a yellow oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     Trifluoro-methanesulfonic acid 4-chloro-5-methoxy-2-nitro-phenyl ester 
     Trifluoro-methanesulfonic acid 4-chloro-2-nitro-phenyl ester 
     Trifluoro-methanesulfonic acid 2-chloro-6-nitro-phenyl ester 
     EXAMPLE 54 (METHOD 26) 
     [4-(3-Dimethylamino-benzoylamino)-phenyl]-carbamic acid t-butyl ester 
     A solution of [4-(3-amino-benzoylamino)-phenyl]-carbamic acid t-butyl ester (505 mg), sodium cyanoborohydride (250 mg), acetic acid (3 drops) and 40% aqueous formaldehyde (4 mL) in 1:2 tetrahydrofuran-methanol (15 mL) is stirred for 15 minutes, and then poured into saturated aqueous sodium bicarbonate and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous potassium carbonate and concentrated under reduced pressure to give a solid which is recrystallized from acetonitrile to provide a pale pink crystalline solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     [4-(3-Dimethylamino-benzoylamino)-phenyl]-carbamic acid tert-butyl ester 
     (3-Bromo-5-trifluoromethyl-phenyl)-dimethyl-amine 
     N-(3-Chloro-5-dimethylamino-phenyl)-acetamide 
     EXAMPLE 55 (METHOD 27) 
     N-(4-Aminophenyl)-2-hydroxybenzamide 
     To a solution of 2-(4-aminophenylcarbamoyl) phenyl acetate (580 mg) in methanol (10 mL) is added saturated sodium bicarbonate (2 mL) and water (3 mL). The mixture is heated at 80° C.for 30 minutes, then poured into half-saturated aqueous sodium chloride and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid. 
     EXAMPLE 56 (METHOD 28) 
     [4-(3-(Hydroxybenzoylamino)phenyl}carbamic acid t-butyl ester 
     To a solution of of 3-(4-aminophenylcarbamoyl) phenyl acetate (4.34 g) in methanol (75 mL) is added 0.1 N aqueous sodium hydroxide (25 mL) and tetrahydrofuran (25 mL). This solution is heated at 40° C. for 30 minutes, then cooled, poured into 1 M hydrochloric acid and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid, which is further purified by trituration with diethyl ether. 
     EXAMPLE 57 (METHOD 29) 
     N-(4-Aminophenyl)-2-hydroxymethylbenzamide 
     To a solution of N-(4-aminophenyl)phthalimide (332 mg) in tetrahydrofuran (4 mL) is added lithium borohydride (1.0 g) and the mixture is stirred for 1 hour at 25° C. The mixture is poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white foam, which when triturated with diethyl ether provides the desired product as a white powder. 
     EXAMPLE 58 (METHOD 30) 
     (3-Chloro-5-dimethylamino-phenyl)-carbamic acid tert-butyl ester 
     To a solution of (3-amino-5-chloro-phenyl)-carbamic acid tert-butyl ester (0.32 g) in toluene (10 mL) is added aqueous formaldehyde (37%, 1.5 mL) then 10% palladium on carbon (0.50 g) and the mixture is stirred under an atmosphere of hydrogen for approximately 15 hours. The solution is then filtered through diatomaceous earth and the filtrate is concentrated under reduced pressure. The residue is chromatographed over silica gel (50% dichloromethane in hexanes is used as the eluant) to provide the desired product as a white solid. 
     EXAMPLE 59 (METHOD 35) 
     N-(4-{3-[3,5-Dichloro-4-(2-hydroxy-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
     To a solution of acetic acid 2-{4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-ethyl ester (0.16 g) in a 1:1 mixture of tetrahydrofuran and methanol (2.5 mL) is added 1N aqueous sodium hydroxide (1 mL) and the mixture is stirred for approximately 2 hours at room temperature. The solution is then poured into 2 M aqueous hydrochloric acid (3 mL), extracted into ethyl acetate, and the extracts are dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with diethyl ether to provide the desired product as a white solid. 
     EXAMPLE 60 (METHOD 36) 
     {4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-acetic acid 
     To a solution of {4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-acetic acid ethyl ester (0.29 g) in a 1:1 mixture of tetrahydrofuran and methanol (4 mL) is added 1N aqueous sodium hydroxide (2 mL) and the mixture is stirred for approximately 2 hours at room temperature. The solution is then poured into 2 M aqueous hydrochloric acid (5 mL), extracted into ethyl acetate, and the extracts are dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with diethyl ether to provide the desired product as a white solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     {(4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-acetic acid 
     {2-[3-(4-Acetylamino-phenyl)-thioureido]-4-chloro-5-methoxy-phenoxy}-acetic acid 
     {4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-5-methoxy-phenoxy}-acetic acid 
     EXAMPLE 61 (METHOD 37) 
     Benzoic acid 2-{4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-ethyl ester 
     To an ice cooled solution of N-(4-{3-[3,5-dichloro-4-(2-hydroxy-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide (0.20 g) in pyridine (2 mL) and tetrahydrofuran (0.5 mL) is added benzoyl chloride (0.08 g) and the mixture is stirred at 0° C. for 1.5 hours. The mixture is then diluted with ethyl acetate, washed successively two times with 2% aqueous hydrochloric acid, once with saturated aqueous sodium chloride, then dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure the residue is chromatographed over silica gel (5% methanol in dichloromethane is used as the eluant) and product containing fractions are combined, evaporated under reduced pressure, and the residue is recrystallized from acetone-hexanes to provide the desired product as a white powder. 
     EXAMPLE 62 (METHOD 38) 
     Methanesulfonic acid 2-{4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-ethyl ester 
     To an ice cooled solution of N-(4-{3-[3,5-dichloro-4-(2-hydroxy-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide (0.20 g) in pyridine (2 mL) and tetrahydrofuran (0.5 mL) is added methanesulfonyl chloride (0.11 g) and the solution is stirred at 0° C. for 45 minutes. The reaction mixture is then diluted with ethyl acetate, washed successively twice with 2% aqueous hydrochloric acid, once with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. After removing the solvents by evaporation under reduced pressure the resulting residue is recrystallized from acetone-hexanes to give the desired product as a white powder. 
     EXAMPLE 63 (METHOD 39) 
     N-(4-{3-[3,5-Dichloro-4-(2-dimethylamino-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
     To a solution of methanesulfonic acid 2-{4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichlorophenoxy}-ethyl ester (0.33 g) in tetrahydrofuran (6 mL) is added aqueous dimethyl-amine (8.8 M, 0.5 mL) and the mixture is stirred at room temperature for 5 days. The reaction mixture is then diluted with ethyl acetate, then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure the residue is chromatographed over silica gel (pure methanol is used as the eluant). Pooled product containing fractions are evaporated under reduced pressure and the residue is recrystallized from acetonitrile to provide the desired product as a white powder. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-(4-{3-[3,5-Dichloro-4-(2-dimethylamino-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
     Benzoic acid 2-{4-[3-(4-acetylamino-phenyl)-thioureido]-2,6-dichloro-phenoxy}-ethyl ester 
     EXAMPLE 64 (METHOD 40) 
     Furan-2-carboxylic acid (4-{3-[4-(1-amino-ethyl)-3-chloro-phenyl]-thioureido}-phenyl)-amide 
     To a solution of tin(II) chloride dihydrate (0.25 g) in methanol (2.5 mL) is added furan-2-carboxylic acid (4-{3-[4-(1-azido-ethyl)-3-chloro-phenyl]-thioureido}-phenyl)-amide (0.22 g) and the solution is stirred for approximately 15 hours at room temperature. The solution is then diluted with ethyl acetate, washed successively with saturated aqueous sodium bicarbonate then saturated aqueous sodium chloride, then dried over anhydrous sodium sulfate. After removal of the solvent by evaporation under reduced pressure the residue is chromatographed over silica gel (8% methanol in dichloromethane containing 1% triethylamine is used as the eluant) to provide the desired product as a yellow solid. 
     EXAMPLE 65 (METHOD 41) 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-isothiocyanato-phenyl)-amide 
     To a ice cooled solution of 1,1′-thiocarbonyldiimidazole (7.28 g) in tetrahydrofuran (50 mL) is added [1,2,3]-thiadiazole-4-carboxylic acid (4-amino-phenyl) amide (9.0 g) in tetrahydrofuran (100 mL). After approximately one hour the solvent is removed by evaporation and the residue is dissolved in ethyl acetate. Diethyl ether is added to precipitate the crude product, which is then collected by filtration, dissolved in dichloromethane, and passed through a plug of hydrous magnesium silicate. After removal of solvents, the residue is recrystallized from ethyl acetate-hexanes to provide the desired product as a slightly yellow solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     2-Fluoro-N-(4-isothiocyanato-phenyl)-benzamide 
     Furan-2-carboxylic acid (4-isothiocyanato-phenyl)-amide 
     [1,2,3]Thiadiazole-4-carboxylic acid (4-isothiocyanato-phenyl)-amide 
     Thiazole-4-carboxylic acid (4-isothiocyanato-phenyl)-amide 
     EXAMPLE 66 (METHOD 42) 
     N,N-Dimethyl-5-trifluoromethyl-benzene-1,3-diamine 
     To a solution of 3-amino-5-bromo-benzotrifluoride (1.0 g) in degassed (argon) tetrahydrofuran (2 mL) is added bis-(tri-o-tolylphosphino)palladium (0.15 g), a solution of dimethylamine in tetra-hydrofuran (2M, 4.2 mL), and a solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (1M, 10.4 mL). The reaction mixture is heated in a sealed vessel to 100° C. for approximately 2.5 hours to complete the reaction. The mixture is then cooled to room temperature, quenched by addition of water, and diluted with ethyl acetate. The product is extracted three times into 5% aqueous hydrochloric acid, and pooled acidic extracts are then basified with cooling by addition of 5N aqueous sodium hydroxide. This basic solution is then extracted with ethyl acetate, and these pooled organic extracts are washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and evaporated to dryness under reduced pressure. The resulting residue is chromatographed over silica gel (20-30% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a slightly tinted solid. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-phenylamine 
     3-Morpholin-4-yl-5-trifluoromethyl-phenylamine 
     3-Piperidin-1-yl-5-trifluoromethyl-phenylamine 
     3-Pyrrolidin-1-yl-5-trifluoromethyl-phenylamine 
     N,N-Dimethyl-5-trifluoromethyl-benzene-1,3-diamine 
     N-Isobutyl-N-methyl-5-trifluoromethyl-benzene-1,3-diamine 
     N-Butyl-N-methyl-5-trifluoromethyl-benzene-1,3-diamine 
     EXAMPLE 67 (METHOD 43) 
     (3-Isobutyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
     To a sealed tube containing tetrahydrofuran (5 mL) that is capped with a rubber septum and cooled in a dry ice-acetone bath is bubbled isobutylene for about 5 minutes. A solution of 9-borabicyclo[3.3.1]nonane in tetrahydrofuran (0.5 M, 11 mL) is added, the vessel is sealed with a teflon cap, slowly warmed to room temperature and kept at room temperature for approximately 2.5 hours. The mixture is then re-cooled in a dry ice-acetone bath, the teflon cap is replaced by a rubber septum, and argon is bubbled through the mixture with venting to removed the excess isobutylene. A solution of (3-bromo-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (1.7 g) in tetrahydrofuran (12 mL) is added, followed by [1,1′-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex (0.12 g), and then 3N aqueous sodium hydroxide. The vessel is again sealed with the teflon cap and is then heated to 65° C. for approximately 15 hours. The mixture is then cooled to room temperature, diluted with hexanes, washed with water, saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure. The resulting oil is chromatographed over silica gel (5% ethyl acetate in hexanes is used as the eluant) to provide the desired product as a white powder. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     [3-(2-Methyl-butyl)-5-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester 
     (3-Isobutyl-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester 
     EXAMPLE 68 (METHOD 44) 
     2-(3,5-Dichloro-phenylsulfanyl)-ethylamine 
     To a solution of (3,5-dichlorophenylthio)acetonitrile (1.2 g) in 3.0 mL of ethylene glycol dimethyl ether is added 0.61 mL of 10M borane dimethyl sulfide complex and the mixture heated at reflux for 0.5 hours. The reaction is cooled in an ice bath and 2.0 mL of water and 2.0 mL of concentrated hydrochloric acid is added. This mixture is heated at reflux for 0.5 hr. The clear solution is then cooled and basified with 5N sodium hydroxide and extracted with ether. The ether extract is dried over potassium carbonate, filtered and concentrated to give 1.0 g of a colorless oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     2-(3-Bromo-phenylsulfanyl)-ethylamine 
     2-(4-Bromo-phenoxy)-ethylamine 
     2-(4-Iodo-phenoxy)-ethylamine 
     2-(3,4-Dichloro-phenoxy)-ethylamine 
     2-(3-Chloro-phenylsulfanyl)-ethylamine 
     2-(3,4-Dichloro-phenylsulfanyl)-ethylamine 
     3-(4-Bromo-phenyl)-propylamine 
     2-(2-Fluoro-phenoxy)-ethylamine 
     2-(2-Chloro-phenoxy)-ethylamine 
     2-(3-Bromo-phenoxy)-ethylamine 
     2-(3-Fluoro-phenoxy)-ethylamine 
     2-(3-Iodo-phenoxy)-ethylamine 
     2-(3,5-Dichloro-phenylsulfanyl)-ethylamine 
     2-Phenylsulfanyl-ethylamine 
     1-(2-Chloro-phenyl)-ethylamine 
     EXAMPLE 69 (METHOD 45) 
     N-(1-Naphthalen-2-yl-ethyl)-formamide 
     A mixture of 2-acetylnaphthylene (3.0 g), ammonium formate (11.0 g), formic acid (3.3 mL), and formamide (3.5 mL) is heated at 190° C. for 3 hours. The mixture is cooled, poured into water and extracted with ether. The ether extract is dried with anhydrous potassium carbonate, filtered and concentrated to give a yellow oil, which is crystallized from toluene-hexanes to give a white solid, 1.97 g. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     N-[1-(4-Fluoro-phenyl)-2-methyl-propyl]-formamide 
     N-(1-Naphthalen-2-yl-ethyl)-formamide 
     EXAMPLE 70 (METHOD 46) 
     1-(2-Naphthyl)ethylamine 
     A mixture of N-(1-naphthalen-2-yl-ethyl)-formamide (1.12 g), ethanol (10 mL) and 5 N sodium hydroxide (10 mL) is heated at reflux for 1 hour. The solution is cooled, poured into water and extracted with ether. The ether solution is dried with anhydrous potassium carbonate. filtered and concentrated to give the product (0.95 g) as a pale yellow oil. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     1-(3-Trifluoromethyl-phenyl)-ethylamine 
     1-(4-Fluoro-phenyl)-2-methyl-propylamine 
     [3-(1-Amino-ethyl)-phenyl]-dimethyl-amine 
     3-(1-Amino-ethyl)-benzonitrile 
     EXAMPLE 71 (METHOD 47) 
     1-(3-Trifluoromethyl-phenyl)-ethanone O-methyl-oxime 
     Methoxylamine hydrochloride (2.33 g) is added to a solution of 3′-(trifluoromethyl)-acetophenone (1.5 g) in ethanol (20 mL) and pyridine (2 mL). The solution is heated at reflux for 45 minutes. The reaction mixture is then cooled, concentrated under reduced pressure and partitioned between water and ethyl acetate. The aqueous layer is extracted with ethyl acetate. The combined organic layers are washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the desired product as a colorless oil (1.61 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     3,5-Bis-trifluoromethyl-benzaldehyde oxime 
     1-(4-Fluoro-phenyl)-propan-1-one O-methyl-oxime 
     1-(2-Chloro-phenyl)-ethanone O-methyl-oxime 
     1-(3-Bromo-phenyl)-ethanone O-methyl-oxime 
     1-(3-Chloro-phenyl)-ethanone O-methyl-oxime 
     1-p-Tolyl-ethanone O-methyl-oxime 
     1-(4-Fluoro-phenyl)-pentan-1-one O-methyl-oxime 
     1-(4-Fluoro-phenyl)-2-phenyl-ethanone O-methyl-oxime 
     1-o-Tolyl-ethanone O-methyl-oxime 
     1-m-Tolyl-ethanone O-methyl-oxime 
     1-(2-Fluoro-phenyl)-ethanone O-methyl-oxime 
     3-(1-Methoxyimino-ethyl)-benzonitrile 
     4-(1-Methoxyimino-ethyl)-benzonitrile 
     1-(4-Methoxy-phenyl)-ethanone O-methyl-oxime 
     1-(2-Methoxy-phenyl)-ethanone O-methyl-oxime 
     1-(4-Dimethylamino-phenyl)-ethanone O-methyl-oxime 
     1-(2-Trifluoromethyl-phenyl)-ethanone O-methyl-oxime 
     1-(3-Methoxy-phenyl)-ethanone O-methyl-oxime 
     1-(3-Trifluoromethyl-phenyl)-ethanone O-methyl-oxime 
     1-(4-Trifluoromethyl-phenyl)-ethanone O-methyl-oxime 
     1-Furan-2-yl-ethanone O-methyl-oxime 
     1-Pyridin-4-yl-ethanone O-methyl-oxime 
     1-(1-Methyl-1H-pyrrol-2-yl)-ethanone O-methyl-oxime 
     1-Thiophen-3-yl-ethanone O-methyl-oxime 
     (4-Fluoro-phenyl)-phenyl-methanone O-methyl-oxime 
     1-(4-methoxyphenyl)ethanone O-methyloxime 
     1-(3-Chloro-4-methoxy-phenyl)-ethanone O-methyl-oxime 
     4-(1-Methoxyimino-ethyl)-benzenesulfonamide 
     4-(1-Methoxyimino-ethyl)-N,N-dimethyl-benzenesulfonamide 
     1-[4-(Piperidine-1-sulfonyl)-phenyl]-ethanone O-methyl-oxime 
     4-(1-Methoxyimino-ethyl)-N,N-dipropyl-benzenesulfonamide 
     2-Fluoro-N-[4-(1-methoxyimino-ethyl)-phenyl]-benzamide 
     1-(3,5-Bis-trifluoromethyl-phenyl)-ethanone O-methyl-oxime 
     1-[4-(1H-Imidazol-1-yl)phenyl]-1-ethanone, O-methyloxime 
     1-[4-(Trifluoromethyl)phenyl]-1-ethanone, O-methyloxime 
     1-[1,1′-Biphenyl]-4-yl-1-ethanone, O-methyloxime 
     1-(4-Methylphenyl)-1-ethanone, O-methyloxime 
     1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(3,5-bis(trifluoromethyl)phenyl]ethanone O-benzyloxime 
     1-[4-chloro-3-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-[2-fluoro-4-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-[2-fluoro-5-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(2,4-dichlorophenyl)ethanone O-methyloxime 
     1-(2,4-dimethylphenyl)ethanone O-methyloxime 
     1-[2,4-bis(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(3-bromophenyl)ethanone O-methyloxime 
     1-(3-methylphenyl)ethanone O-methyloxime 
     1-[4-(4-morpholinyl)phenyl]ethanone O-methyloxime 
     1-(2-chloro-4-fluorophenyl)ethanone O-methyloxime 
     1-(4-bromo-2-fluorophenyl)ethanone O-methyloxime 
     1-(3,4-difluorophenyl)ethanone O-methyloxime 
     1-[3-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-[2-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(2,4-difluorophenyl)ethanone O-methyloxime 
     1-[3-fluoro-4-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(3,4-dichlorophenyl)ethanone O-methyloxime 
     1-[4-fluoro-2-(trifluoromethyl)phenyl]ethanone O-methyloxime 
     1-(3-chloro-4-fluorophenyl)ethanone O-methyloxime 
     1-(4-chloro-3-fluorophenyl)ethanone O-methyloxime 
     1-(2,5-difluorophenyl)ethanone O-methyloxime 
     1-(2-bromo-4-fluorophenyl)ethanone O-methyloxime 
     1-(3,4-dibromophenyl)ethanone O-methyloxime 
     1-(2-bromophenyl)ethanone O-methyloxime 
     EXAMPLE 72 (METHOD 48) 
     1-(2-Trifluoromethyl-phenyl)-ethylamine 
     Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     1-(3-Methoxy-phenyl)-ethylamine 
     1-(4-Fluoro-phenyl)-propylamine 
     1-Naphthalen-2-yl-ethylamine 
     4-(1-Amino-ethyl)-benzonitrile 
     1-(4-Trifluoromethyl-phenyl)-ethylamine 
     1-(4-Methoxy-phenyl)-ethylamine 
     1-Prop-2-ynyl-pyrrolidine 
     1-(2-Methoxy-phenyl)-ethylamine 
     1-m-Tolyl-ethylamine 
     1-(2-Bromo-phenyl)-ethylamine 
     1-o-Tolyl-ethylamine 
     C-(4-Fluoro-phenyl)-C-phenyl-methylamine 
     1-(4-Fluoro-phenyl)-pentylamine 
     1-(4-Fluoro-phenyl)-2-phenyl-ethylamine 
     1-(2-Trifluoromethyl-phenyl)-ethylamine 
     1-(3-Bromo-phenyl)-ethylamine 
     1-(3-Chloro-phenyl)-ethylamine 
     [4-(1-Amino-ethyl)-phenyl]-dimethyl-amine 
     1-(1-Methyl-1H-pyrrol-2-yl)-ethylamine 
     1-Thiophen-3-yl-ethylamine 
     1-[3,5-bis(trifluoromethyl)phenyl]propylamine 
     1-[3,5-bis(trifluoromethyl)phenyl]-1-butanamine or 
     1-[3,5-bis(trifluoromethyl)phenyl]butylamine 
     1-[3,5-bis(trifluoromethyl)phenyl]-1-pentanamine 
     1-(4-methylphenyl)ethanamine 
     1-[3-(trifluoromethyl)phenyl]ethylamine 
     1-[4-(trifluoromethyl)phenyl]ethylamine 
     1-(3-methylphenyl)ethanamine 
     1-(3,4-dichlorophenyl)ethanamine 
     1-(2-Bromo-phenyl)-ethylamine 
     1-(2-Trifluoromethyl-phenyl)-ethylamine 
     1-(3-Bromo-phenyl)-ethylamine 
     1-(3-Chloro-4-methoxy-phenyl)-ethylamine 
     4-(1-Amino-ethyl)-N,N-dimethyl-benzenesulfonamide 
     1-[4-(Piperidine-1-sulfonyl)-phenyl]-ethylamine 
     1-Quinolin-6-yl-ethylamine 
     1-(3,5-Bis-trifluoromethyl-phenyl)-ethylamine 
     4-[(1S)-1-aminoethyl]benzonitrile 
     (S)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanamine(S)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanamine 
     1-Biphenyl-4-yl-ethylamine 
     1-(4-Fluoro-phenyl)-ethylamine 
     1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanamine 
     1-[4-chloro-3-(trifluoromethyl)phenyl]ethanamine 
     N-{4-[(1R)-1-aminoethyl]phenyl}-1,2,3-thiadiazole-4-carboxamide 
     N-{4-[(1S)-1-aminoethyl]phenyl}-1,2,3-thiadiazole-4-carboxamide 
     1-[3-fluoro-5-(trifluoromethyl)phenyl]ethylamine 
     1-[2-fluoro-4-(trifluoromethyl)phenyl]ethylamine 
     1-[2-fluoro-5-(trifluoromethyl)phenyl]ethylamine 
     1-(2,4-dichlorophenyl)ethylamine 
     1-(2,4-dimethylphenyl)ethylamine 
     1-[2,4-bis(trifluoromethyl)phenyl]ethylamine 
     1-(2-chloro-4-fluorophenyl)ethylamine 
     1-(3,4-difluorophenyl)ethylamine 
     1-(4-bromo-2-fluorophenyl)ethylamine 
     1-(3-fluorophenyl)ethylamine 
     1-(2,4-difluorophenyl)ethylamine 
     1-[3-fluoro-4-(trifluoromethyl)phenyl]ethylamine 
     1-[4-fluoro-2-(trifluoromethyl)phenyl]ethylamine 
     1-(3-chloro-4-fluorophenyl)ethylamine 
     1-(4-chloro-3-fluorophenyl)ethylamine 
     1-(3,4-dibromophenyl)ethylamine 
     1-(2-bromo-4-fluorophenyl)ethanamine 1-(2-bromo-4-fluorophenyl)ethylamine 
     EXAMPLE 73 (METHOD 49) 
     (2-Fluoro-5-trifluoromethyl-phenoxy)-acetonitrile 
     A solution of 2-fluoro-5-trifluoromethylphenol (25 g) in reagent grade acetone (0.55 L) is treated with solid potassium carbonate (7.7 g) followed by the rapid addition of neat bromoacetonitrile (10 mL). The heterogenous mixture is stirred vigorously for approximately 20 hours whereupon it is poured into water and extracted into diethyl ether. The combined ether extracts are washed with saturated sodium chloride and dried over anhydrous potassium carbonate. Filtration and concen-tration under reduced pressure gives a pale orange solid which is then chromatographed on silica gel, eluting with dichloromethane, to give the desired product as white solid (28.3 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     (3-Bromo-phenylsulfanyl)-acetonitrile 
     (3-Chloro-phenylsulfanyl)-acetonitrile 
     (4-Iodo-phenoxy)-acetonitrile 
     (3-Trifluoromethyl-phenylsulfanyl)-acetonitrile 
     (3,5-Dichloro-phenylsulfanyl)-acetonitrile 
     (3,4-Dichloro-phenylsulfanyl)-acetonitrile 
     (3,4-Dichloro-phenoxy)-acetonitrile 
     (2-Fluoro-phenoxy)-acetonitrile 
     (3-Fluoro-phenoxy)-acetonitrile 
     (2-Chloro-phenoxy)-acetonitrile 
     (3-Bromo-phenoxy)-acetonitrile 
     (2-Fluoro-5-trifluoromethyl-phenoxy)-acetonitrile 
     (3-Iodo-phenoxy)-acetonitrile 
     (4-Bromo-phenoxy)-acetonitrile 
     EXAMPLE 74 (METHOD 50) 
     3-Fluoro-5-trifluoromethylphenethylamine tosylate 
     A solution of 2.5 g of 3-fluoro-5-trifluoromethylphenylacetonitrile and 2.34 g (12.3 mmol) of p-toluenesulfonic acid in 75 ml of ethylene glycol monomethyl ether is hydrogenated for 3 hours at room temperature at 40 psi, using 200 mg 10% palladium on carbon catalyst. The catalyst is filtered off and the solvent evaporated to half the volume. Upon standing, the p-toluenesulfonic acid salt of the desired 3-fluoro-5-trifluoromethylphenethylamine crystallizes. The white crystals. 4.26 g (91%) are collected by filtration. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     2-(3,5-Difluoro-phenyl)-ethylamine 
     2-(4-Trifluoromethyl-phenyl)-ethylamine 
     2-(3,4-Difluoro-phenyl)-ethylamine 
     2-(2-Fluoro-phenyl)-ethylamine 
     2-(3-Fluoro-5-trifluoromethyl-phenyl)-ethylamine 
     2-(2-Fluoro-3-trifluoromethyl-phenyl)-ethylamine 
     2-(2,4-Bis-trifluoromethyl-phenyl)-ethylamine 
     2-(4-Fluoro-3-trifluoromethyl-phenyl)-ethylamine 
     EXAMPLE 75 (METHOD 51) 
     (4-Aminomethyl-2-trifluoromethyl-phenyl)-dimethyl-amine 
     A solution of 4-dimethylamino-3-trifluoromethylbenzonitrile (0.35 g) in tetrahydrofuran (2 mL) is slowly added to a suspension of lithium aluminum hydride (0.1 g) in tetrahydrofuran (2 mL) at 0° C. and stirred under an atmosphere of argon for 2 hours. While at 0° C. water (0.1 mL) is slowly added followed by 5% sodium hydroxide (0.1 mL) and water (0.3 mL). The resulting gray solid is filtered and washed with tetrahydrofuran. The filtrates are collected and concentrated under reduced pressure and the resulting oil is chromatographed over silica gel (15% methanol in methylene chloride is used as the eluant) to provide the desired product as a pale orange oil (0.164 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     4-Piperidin-1-yl-3-trifluoromethyl-benzylamine 
     (4-Aminomethyl-2-trifluoromethyl-phenyl)-dimethyl-amine 
     4-(4-Methyl-piperazin-1-yl)-3-trifluoromethyl-benzylamine 
     (3-Aminomethyl-5-trifluoromethyl-phenyl)-dimethyl-amine 
     [3-(2-Amino-ethyl)-5-trifluoromethyl-phenyl]-dimethyl-amine 
     [4-(2-Amino-ethyl)-2-methyl-phenyl]-dimethyl-amine 
     EXAMPLE 76 (METHOD 52) 
     3-Dimethylamino-5-trifluoromethyl-benzaldehyde 
     Diisobutylaluminum hydride (10 mL of a 1M solution in methylene chloride) is added dropwise to a solution of 3-dimethylamino-5-trifluoromethylbenzonitrile (1.06 g) in methylene chloride (25 mL) at 0° C. and the mixture stirred for 2 hours. 
     While still at 0° C. a saturated aqueous solution of sodium potassium tartrate (8 mL) is slowly added and the solution is stirred for 1.5 hours. The reaction mixture is then extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to provide the desired product as a yellow solid (0.97 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     3-Dimethylamino-5-trifluoromethyl-benzaldehyde 
     4-Dimethylamino-3-methyl-benzaldehyde 
     EXAMPLE 77 (METHOD 53) 
     Dimethyl-[3-(2-nitro-vinyl)-5-trifluoromethyl-phenyl]-amine 
     Nitromethane (0.473 g) is added to a solution of 3-dimethylamino-5-trifluoromethyl-benzaldehyde (0.885 g) and ammonium acetate (0.339 g) in acetic acid (3.4 mL) and the solution is heated at 110° C. for 6 hours. The reaction mixture is cooled to 0° C. and a solid forms which is filtered and washed with 1:1 water-acetic acid. This solid is recrystallized from ethanol to provide the desired product as a red solid (0.39 g). 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     Dimethyl-[3-(2-nitro-vinyl)-5-trifluoromethyl-phenyl]-amine 
     Dimethyl-[2-methyl-4-(2-nitro-vinyl)-phenyl]-amine 
     EXAMPLE 78 (METHOD 54) 
     3-(4-Bromo-phenyl)-propionitrile 
     Diethylazodicarboxylate (5.2 g) is added dropwise to a solution of 4-bromo-phenethylalcohol (2.01 g), and triphenylphosphine (7.9 g) in diethyl ether (16 mL) at 0° C. The reaction mixture is stirred for 10 minutes and a solution of acetone cyanohydrin (2.6 g) in diethyl ether (10 mL) is added. The clear orange solution is stirred for 5 minutes at 0° C. and then at 25° C. for 12 hours. The reaction mixture is then filtered, and washed with diethyl ether. The filtrate is concentrated under reduced pressure and chromatographed over silica gel (10% ethyl acetate-hexanes is used as the eluant) to provide the desired product as a pale yellow oil (2.04 g). 
     EXAMPLE 79 (METHOD 55) 
     3-Dimethylamino-2-isocyano-acrylic acid ethyl ester 
     To a solution of ethyl isocyanoacetate (5.0 g) in ethanol (100 mL) is added N,N-dimethyl-formamide dimethyl acetal (6.5 g) dropwise with stirring over 10 minutes. The reaction is stirred for 24 hours and the ethanol is evaporated. The resulting oil is passed through magnesium silicate using 50% ethyl acetate-hexanes as the eluant. The solvents are removed and the resulting oil is crystallized from ethyl acetate-hexanes to yield light yellow needles, 3.0 g. 
     EXAMPLE 80 (METHOD 56) 
     4-Carboethoxythiazole 
     A solution of 3-dimethylamino-2-isocyano-acrylic acid ethyl ester (1.0 g) and triethylamine (3.0 g) in tetrahydrofuran (30 mL) is treated with gaseous hydrogen sulfide until all starting material is consumed. The mixture is concentrated to an oil and purified by column chromatography using silica and 25% ethyl acetate-hexanes as the eluant. The purified material (0.61 g) is isolated as an oil. 
     EXAMPLE 81 (METHOD 34) 
     N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-2-fluoro-benzamide 
     A suspension of N-(4-amino-phenyl)-2-fluoro-benzamide (0.43 g) in acetonitrile (4mL) is treated with 5-chloro-2,4-dimethoxyphenylisocyanate (0.40 g). The mixture becomes a solution and is allowed to stand for 12 hours. A white solid forms and is collected by filtration (0.79 g). [M+H] 444. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     
       
         
               
               
               
             
           
               
                   
               
               
                 EX 
                   
                   
               
               
                 NO. 
                 M + H 
                 COMPOUND NAME 
               
               
                   
               
             
             
               
                 81 
                 445 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-2-fluoro-benzamide 
               
               
                 82 
                 441 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-2-methyl-benzamide 
               
               
                 83 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-amide 
               
               
                 84 
                 443 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-phenyl} amide 
               
               
                 85 
                 453 
                 N-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido]-phenyl}-2-fluoro-benzamide 
               
               
                 86 
                 409 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-ureido]-phenyl}-amide 
               
               
                 87 
                 486 
                 N-{4-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-phenyl}-2-fluoro-benzamide 
               
               
                 88 
                 458 
                 Furan-2-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-ureido]-phenyl}-amide 
               
               
                 89 
                 476 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-ureido]-phenyl}-amide 
               
               
                 90 
                 423 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-ureido]-phenyl}-amide 
               
               
                   
               
             
          
         
       
     
     EXAMPLE 91 (METHOD 31) 
     N-(5-{[({((1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}-2-pyridinyl)-1,3-thiazole-4-carboxamide 
     A mixture of N-(5-isothiocyanato-2-pyridinyl)-1,3-thiazole-4-carboxamide (0.36 g) and (S)-alpha-methyl-3,5-bis(trifluoromethyl)-benzenemethanamine (0.36 g) is heated with acetonitrile (10 mL) until all solids are dissolved. The solution is allowed to stand for 12 hours. A white solid forms and is collected by filtration (0.40 g). [M+H] 520. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     
       
         
               
               
               
             
           
               
                   
               
               
                 EX. 
                   
                   
               
               
                 NO. 
                 M + H 
                 COMPOUND NAME 
               
               
                   
               
             
             
               
                  92 
                 506 
                 [3-Chloro-5-(3-{4-[([1,2,3]thiadiazole-4-carbonyl)-amino]-phenyl}-thioureido)phenyl]-carbamic acid tert-butyl ester 
               
               
                  93 
                 409 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(4-morpholin-4-yl-phenyl)-thiourea 
               
               
                  94 
                 370 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(4-methylsulfanyl-phenyl)-thiourea 
               
               
                  95 
                 338 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-p-tolyl-thiourea 
               
               
                  96 
                 414 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenylsulfanyl}-acetic acid 
               
               
                  97 
                 384 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-[4-(2-hydroxy-ethoxy)-phenyl]-thiourea 
               
               
                  98 
                 340 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-thiourea 
               
               
                  99 
                 395 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-N-methyl-acetamide 
               
               
                 100 
                 381 
                 N-{3-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 101 
                 411 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid ethyl ester 
               
               
                 102 
                 319 
                 1-(2,4-Dimethoxy-phenyl)-3-(4-methoxy-phenyl)-thiourea 
               
               
                 103 
                 346 
                 N-{4-[3-(2,4-Dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 104 
                 316 
                 N-{4-[3-(4-Methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 105 
                 316 
                 N-{4-[3-(2-Methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 106 
                 351 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 107 
                 351 
                 N-{4-[3-(5-Chloro-2-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 108 
                 371 
                 N-{4-[3-(3,5-Dichloro-4-hydroxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 109 
                 385 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 110 
                 381 
                 N-{4-[3-(4-Chloro-2,5-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 111 
                 389 
                 N-{4-[3-(2-Chloro-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 112 
                 389 
                 N-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 113 
                 422 
                 Benzoic acid 4-[3-(4-acetylamino-phenyl)-thioureido]-3-hydroxy-phenylester 
               
               
                 114 
                 457 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                 115 
                 501 
                 Acetic acid 2-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl-carbamoyl}-phenyl ester 
               
               
                 116 
                 461 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-4-fluoro-benzamide 
               
               
                 117 
                 461 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-fluoro-benzamide 
               
               
                 118 
                 461 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 119 
                 473 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methoxy-benzamide 
               
               
                 120 
                 473 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-methoxy-benzamide 
               
               
                 121 
                 473 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-4-methoxy-benzamide 
               
               
                 122 
                 443 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 123 
                 417 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-methane-sulfonamide 
               
               
                 124 
                 331 
                 N-{4-[3-(3-Nitro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 125 
                 339 
                 1-(3-Chloro-4-methoxy-phenyl)-3-(3-nitro-phenyl)-thiourea 
               
               
                 126 
                 337 
                 N-{4-[3-(5-Chloro-2-hydroxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 127 
                 439 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid tert-butyl ester 
               
               
                 128 
                 351 
                 N-{4-[3-(3-Chloro-4-hydroxy-5-methyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 129 
                 385 
                 N-{4-[3-(3,5-Dichloro-4-hydroxy-2-methyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 130 
                 318 
                 N-{4-[3-(2,4-Dihydroxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 131 
                 414 
                 N-{4-[3-(2,4-Dimethoxy-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 132 
                 332 
                 N-{4-[3-(2-Hydroxy-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 133 
                 465 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]-phenyl}-4-fluoro-benzamide 
               
               
                 134 
                 500 
                 3-Acetylamino-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 135 
                 488 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-nitro-benzamide- 
               
               
                 136 
                 486 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-dimethylamino-benzamide 
               
               
                 137 
                 536 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-methane-sulfony-amino-benzamide 
               
               
                 138 
                 511 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-trifluoro-methyl-benzamide 
               
               
                 139 
                 459 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-hydroxy-benzamide 
               
               
                 140 
                 479 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 141 
                 477 
                 2-Chloro-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 142 
                 522 
                 2-Bromo-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 143 
                 488 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-nitro-benzamide 
               
               
                 144 
                 445 
                 Pyrazine-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 145 
                 463 
                 5-Methyl-thiophene-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 146 
                 494 
                 Quinoline-8-carboxylic acid {4-[3-(5-chloro-,2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 147 
                 446 
                 1-Methyl-1H-pyrrole-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 148 
                 369 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(2-nitro-phenyl)-thiourea 
               
               
                 149 
                 369 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(4-nitro-phenyl)-thiourea 
               
               
                 150 
                 425 
                 N-{4-[3-(5-Bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 151 
                 376 
                 N-{4-[3-(3,4,5-Trimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 152 
                 399 
                 N-{4-[3-(3,5-Dichloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 153 
                 499 
                 Benzo[b]thiophene-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 154 
                 483 
                 Benzofuran-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 155 
                 444 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-isonicotinamide 
               
               
                 156 
                 493 
                 Naphthalene-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 157 
                 493 
                 Naphthalene-1-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 158 
                 494 
                 Isoquinoline-1-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 159 
                 494 
                 Quinoline-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 160 
                 444 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-nicotinamide 
               
               
                 161 
                 478 
                 5-Nitro-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amidecarbamic acid phenyl ester 
               
               
                 162 
                 459 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}- 
               
               
                 163 
                 467 
                 5-Chloro-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 164 
                 439 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid isobutyl ester 
               
               
                 165 
                 397 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid methyl ester 
               
               
                 166 
                 433 
                 Furan-3-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 167 
                 447 
                 3-Methyl-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 168 
                 512 
                 5-Bromo-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 169 
                 512 
                 4-Bromo-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 170 
                 433 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 171 
                 467 
                 {4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid hexyl ester 
               
               
                 172 
                 494 
                 Isoquinoline-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 173 
                 451 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 174 
                 434 
                 1H-[1,2,3]Triazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 175 
                 528 
                 3-Bromo-thiophene-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 176 
                 399 
                 N-{4-[3-(3,5-Dichloro-4-ethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 177 
                 427 
                 N-{4-[3-(4-Butoxy-3,5-dichloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 178 
                 461 
                 N-{4-[3-(4-Benzyloxy-3,5-dichloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 179 
                 381 
                 N-{4-[3-(3-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 180 
                 530 
                 (3-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenylcarbamoyl}-phenyl)-carbamic acid ethyl ester 
               
               
                 181 
                 458 
                 2-Amino-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 182 
                 519 
                 Biphenyl-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 183 
                 469 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-phenyl]-thiourea 
               
               
                 184 
                 487 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-phthalamic acid 
               
               
                 185 
                 473 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-hydroxy-methyl-benzamide 
               
               
                 186 
                 479 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,3-difluoro-benzamide 
               
               
                 187 
                 479 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,5-difluoro-benzamide 
               
               
                 188 
                 479 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,4-difluoro-benzamide 
               
               
                 189 
                 500 
                 2-Acetylamino-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 190 
                 441 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-thiourea 
               
               
                 191 
                 536 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methane-sulfonylamino-benzamide 
               
               
                 192 
                 497 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,3,4-trifluoro-benzamide 
               
               
                 193 
                 533 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2,3,4,5,6-pentafluoro-benzamide 
               
               
                 194 
                 489 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methyl-sulfanyl-benzamide 
               
               
                 195 
                 431 
                 5-Methyl-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-amide 
               
               
                 196 
                 467 
                 5-Difluoromethyl-furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-ureido]-phenyl}-amide 
               
               
                 197 
                 472 
                 N-{4-[3-(5-Iodo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 198 
                 364 
                 N-{4-[3-(5-Fluoro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 199 
                 365 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 200 
                 459 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 201 
                 455 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-4-methoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 202 
                 392 
                 N-{4-[3-(3-Chloro-4-diethylamino-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 203 
                 432 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 204 
                 506 
                 1-Hydroxy-naphthalene-2-carboxylic acid {4-[3-(4-acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-amide 
               
               
                 205 
                 406 
                 N-{4-[3-(3-Chloro-4-morpholin-4-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 206 
                 443 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(3-chloro-4-morpholin-4-yl-phenyl)-thiourea 
               
               
                 207 
                 372 
                 1-(5-Chloro-2,4-dimethoxy-phenyl)-3-(5-chloro-2-methyl-phenyl)-thiourea 
               
               
                 208 
                 501 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-isophthalamic acid methyl ester 
               
               
                 209 
                 487 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-isophthalamic acid 
               
               
                 210 
                 549 
                 3-Benzyloxy-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 211 
                 434 
                 N-(4-{3-[5-Chloro-2-methoxy-4-(4-nitrilo-butoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 212 
                 406 
                 N-(4-{3-[5-Chloro-2-methoxy-4-(2-nitrilo-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 213 
                 406 
                 N-(4-{3-[5-Chloro-4-methoxy-2-(2-nitrilo-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 214 
                 411 
                 N-(4-{3-[5-Chloro-2-(2-hydroxy-ethoxy)-4-methoxy-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 215 
                 411 
                 N-(4-{3-[5-Chloro-4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 216 
                 481 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-5-methoxy-phenoxy}-acetic acid tert-butyl ester 
               
               
                 217 
                 439 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-5-methoxy-phenoxy}-acetic acid methyl ester 
               
               
                 218 
                 481 
                 {2-[3-(4-Acetylamino-phenyl)-thioureido]-4-chloro-5-methoxy-phenoxy}-acetic acid tert-butyl ester 
               
               
                 219 
                 515 
                 3-Butoxy-N-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 220 
                 505 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methane-sulfinyl-benzamide 
               
               
                 221 
                 545 
                 (3-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureldo]-phenylcarbamoyl}-phenoxy)-acetic acid ethyl ester 
               
               
                 222 
                 517 
                 (3-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureldo]-phenylcarbamoyl}-phenoxy)-acetic acid 
               
               
                 223 
                 367 
                 N-{4-[3-(5-Chloro-4-hydroxy-2-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 224 
                 444 
                 Pyridine-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 225 
                 494 
                 Quinoline-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 226 
                 436 
                 N-{4-[3-(5-Chloro-4-methoxy-2-morpholin-4-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 227 
                 394 
                 N-{4-[3-(5-Chloro-2-dimethylamino-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 228 
                 420 
                 N-{4-[3-(5-Chloro-4-methoxy-2-pyrrolidin-1-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 229 
                 434 
                 N-{4-[3-(5-Chloro-4-methoxy-2-piperidin-1-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 230 
                 405 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 231 
                 415 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 232 
                 427 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-phenyl}-3-methoxy-benzamide 
               
               
                 233 
                 387 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 234 
                 411 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                 235 
                 433 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 236 
                 398 
                 Pyridine-2-carboxylic acid {4-[3-(3-chloro-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 237 
                 502 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 238 
                 512 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 239 
                 404 
                 N-{4-[3-(3-Chloro-4-piperidin-1-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 240 
                 364 
                 N-{4-[3-(3-Chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 241 
                 426 
                 N-{4-[3-(4-Benzylamino-3-chloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 242 
                 390 
                 N-{4-[3-(3-Chloro-4-pyrrolidin-1-yl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 243 
                 419 
                 N-(4-{3-[3-Chloro-4-(4-methyl-piperazin-1-yl)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 244 
                 469 
                 N-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 245 
                 422 
                 N-{4-[3-(2-Benzylamino-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 246 
                 484 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 247 
                 508 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-2-methyl-benzamide 
               
               
                 248 
                 530 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-2,6-difluoro-benzamide 
               
               
                 249 
                 495 
                 Pyridine-2-carboxylic acid (4-{3-[3-chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 250 
                 524 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-methyl-amino)-phenyl]-thioureido}-phenyl)-3-methoxy-benzamide 
               
               
                 251 
                 376 
                 N-(4-{3-[3-Chloro-4-(2-nitrilo-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 252 
                 393 
                 N-{4-[3-(4-sec-Butoxy-3-chloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 253 
                 501 
                 Acetic acid 3-{4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl-carbamoyl}-phenyl ester 
               
               
                 254 
                 459 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-hydroxy-benzamide 
               
               
                 255 
                 487 
                 Benzo[1,3]dioxole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 256 
                 527 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-trifluoro-methoxy-benzamide 
               
               
                 257 
                 530 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-(2-dimethylamino-ethoxy)-benzamide 
               
               
                 258 
                 572 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-3-(2-morpholin-4-yl-ethoxy)-benzamide 
               
               
                 259 
                 406 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-cyano-phenyl}-acetamide 
               
               
                 260 
                 521 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2,5-dimethoxy-phenyl}-2-fluoro-benzamide 
               
               
                 261 
                 441 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2,5-dimethoxy-phenyl}-acetamide 
               
               
                 262 
                 527 
                 2-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenoxy}-5-chloro-benzenesulfonic acid 
               
               
                 263 
                 562 
                 2-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenoxy}-4,5-dichloro-benzenesulfonic acid 
               
               
                 264 
                 527 
                 4-Phenyl-[1,2,3]thiadiazole-5-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 265 
                 381 
                 N-(4-{3-[3-Chloro-4-(2-hydroxy-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 266 
                 393 
                 N-{4-[3-(4-Butoxy-3-chloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 267 
                 446 
                 N-(4-{3-[3-Chloro-4-(cyclohexyl-ethyl-amino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 268 
                 365 
                 N-{4-[3-(3-Chloro-4-ethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 269 
                 427 
                 N-{4-[3-(4-Benzyloxy-3-chloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 270 
                 317 
                 {4-[(3-Methyl-furan-2-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
               
               
                 271 
                 456 
                 N-{4-[3-(2-Benzylamino-5-chloro-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 272 
                 420 
                 N-{4-[3-(3-Chloro-5-dipropylamino-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 273 
                 458 
                 N-{4-[3-(4-Allyl-cyclohexyl-amino)-3-chloro-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 274 
                 411 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-phenyl}-acetamide 
               
               
                 275 
                 415 
                 N-{2-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 276 
                 493 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2,5-dimethoxy-phenyl}-amide 
               
               
                 277 
                 486 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-cyano-phenyl}-2-fluoro-benzamide 
               
               
                 278 
                 495 
                 N-{2-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 279 
                 465 
                 5-Methyl-[1,2,3]thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 280 
                 517 
                 5-Furan-3-yl-[1,2,3]thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}amide 
               
               
                 281 
                 527 
                 5-Phenyl-[1,2,3]thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 282 
                 458 
                 N-(4-{3-[3-Chloro-4-(octahydro-quinolin-1-yl)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 283 
                 458 
                 N-[5-[[[(5-Chloro-2,4-dimethoxyphenyl)amino]thioxomethyl]amino]-2-pyridinyl]-2-methylbenzamide 
               
               
                 284 
                 434 
                 Furan-2-carboxylic acid {5-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-2-yl}-amide 
               
               
                 285 
                 425 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-5-methyl-phenyl}-acetamide 
               
               
                 286 
                 505 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-5-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 287 
                 477 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-5-methyl-phenyl}-amide 
               
               
                 288 
                 517 
                 4-Furan-3-yl-[1,2,3]thiadiazole-5-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 289 
                 462 
                 N-{5-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-2-yl}-2-fluoro-benzamide 
               
               
                 290 
                 384 
                 N-{4-[3-(4-Methoxy-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 291 
                 394 
                 N-[4-(3-{3-Chloro-4-[(2-hydroxy-ethyl)-methyl-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                 292 
                 485 
                 N-{2-Benzoyl-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 293 
                 565 
                 N-{2-Benzoyl-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 294 
                 537 
                 Furan-2-carboxylic acid {2-benzoyl-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 295 
                 475 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 296 
                 447 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methyl-phenyl}-amide 
               
               
                 297 
                 395 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methyl-phenyl}-acetamide 
               
               
                 298 
                 435 
                 N-[4-(3-{3-Chloro-4-[(3-dimethylamino-propyl)-methyl-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                 299 
                 418 
                 N-{4-[3-(3-Chloro-4-cyclohexylamino-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 300 
                 421 
                 N-[4-(3-{3-Chloro-4-[(2-dimethylamino-ethyl)-methyl-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                 301 
                 580 
                 5-[[[(5-Chloro-2,4-dimethoxyphenyl)amino]thioxomethyl]amino]-2-[(2-fluorobenzoyl)amino]-N-phenyl-benzamide 
               
               
                 302 
                 552 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-phenylcarbamoyl-phenyl}-amide 
               
               
                 303 
                 491 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-phenyl}-2-fluoro-benzamide 
               
               
                 304 
                 463 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methoxy-phenyl}-amide 
               
               
                 305 
                 449 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-trifluoromethyl-phenyl}-acetamide 
               
               
                 306 
                 458 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-cyano-phenyl}-amide 
               
               
                 307 
                 467 
                 Furan-2-carboxylic acid {2-chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 308 
                 501 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-trifluoromethyl-phenyl}-amide 
               
               
                 309 
                 395 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-acetamide 
               
               
                 310 
                 475 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 311 
                 447 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-amide 
               
               
                 312 
                 378 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-acetamide 
               
               
                 313 
                 408 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-carbamic acid ethyl ester 
               
               
                 314 
                 382 
                 N-{5-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-2-yl}-acetamide 
               
               
                 315 
                 509 
                 N-(4-{3-[4-(1-Benzyl-piperidin-4-ylamino)-3-chloro-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 316 
                 407 
                 N-(4-{3-[3-Chloro-4-(2-dimethylamino-ethylamino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 317 
                 408 
                 N-[4-(3-{3-Chloro-4-[(2-methoxy-ethyl)-methyl-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                 318 
                 421 
                 N-(4-{3-[3-Chloro-4-(3-dimethylamino-propylamino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 319 
                 495 
                 N-(4-{3-[4-(1-Benzyl-pyrrolidin-3-ylamino)-3-chloro-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 320 
                 483 
                 Furan-2-carboxylic acid {5-chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-hydroxy-phenyl}-amide 
               
               
                 321 
                 431 
                 N-{5-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-hydroxy-phenyl}-acetamide 
               
               
                 322 
                 511 
                 (5H,11H-Benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)-(2-chloro-4-imidazol-1-yl-phenyl)-methanone 
               
               
                 323 
                 451 
                 [1,2,3]Thiadiazole-5-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 324 
                 483 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-naphthalen-1-yl}-amide 
               
               
                 325 
                 511 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-naphthalen-1-yl}-2-fluoro-benzamide 
               
               
                 326 
                 429 
                 N-{5-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-acetamide 
               
               
                 327 
                 509 
                 N-{5-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 328 
                 481 
                 Furan-2-carboxylic acid (5-chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-2-methyl-phenyl}-amide 
               
               
                 329 
                 431 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-naphthalen-1-yl}-acetamide 
               
               
                 330 
                 416 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 331 
                 561 
                 Furan-2-carboxylic acid [4-(3-{4-[(1-benzyl-pyrrolidin-3-yl)-methyl-amino]-3-chloro-phenyl}-thioureido)-phenyl]-amide 
               
               
                 332 
                 513 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-phenyl}-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                 333 
                 463 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 334 
                 420 
                 N-(4-{3-[3-Chloro-4-(1-methyl-pyrrolidin-3-yloxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 335 
                 434 
                 N-(4-{3-[3-Chloro-4-(1-methyl-piperidin-4-yloxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 336 
                 422 
                 N-(4-{3-[3-Chloro-4-(3-dimethylamino-propoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 337 
                 425 
                 2-Acetylamino-5-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-benzoic acid 
               
               
                 338 
                 505 
                 5-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-(2-fluoro-benzoylamino)-benzoic acid 
               
               
                 339 
                 477 
                 5-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-[(furan-2-carbonyl)-amino]-benzoic acid 
               
               
                 340 
                 545 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-2,6-difluoro-benzamide 
               
               
                 341 
                 503 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-{3-chloro-4-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 342 
                 443 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                 343 
                 408 
                 N-(4-{3-[3-Chloro-4-(2-dimethylamino-ethoxy)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 344 
                 499 
                 Furan-2-carboxylic acid [4-(3-{3-chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 345 
                 419 
                 N-{4-[3-(3-Chloro-4-cyclohexyloxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 346 
                 440 
                 N-{4-[3-(3-Chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                 347 
                 493 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methyl-phenyl}-2,6-difluoro-benzamide 
               
               
                 348 
                 462 
                 N-{4-[3-(3-Chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 349 
                 531 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-phenyl}-thioureido)-phenyl]-2,6-difluoro-benzamide 
               
               
                 350 
                 427 
                 Pyridine-2-carboxylic acid {4-[3-(3-chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 351 
                 430 
                 Pyridine-2-carboxylic acid {4-[3-(3-chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 352 
                 428 
                 Pyridine-2-carboxylic acid {4-[3-(5-chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 353 
                 417 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 354 
                 496 
                 Pyridine-2-carboxylic acid [4-(3-{3-chloro-4-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 355 
                 495 
                 N-{3-Chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 356 
                 467 
                 Furan-2-carboxylic acid {3-chloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 357 
                 515 
                 N-{4-[3-(3-Chloro-4-cyclohexylsulfanyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 358 
                 449 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-trifluoromethyl-phenyl}-acetamide 
               
               
                 359 
                 529 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-tritluoromethyl-phenyl}-2-fluoro-benzamide 
               
               
                 360 
                 421 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-dimethyl-amino-acetamide 
               
               
                 361 
                 473 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-dimethylamino-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 362 
                 501 
                 N-(4-{3-[3-Chloro-4-(2-dimethylamino-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 363 
                 461 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-piperidin-1-yl-acetamide 
               
               
                 364 
                 541 
                 N-(4-{3-[3-Chloro-4-(2-piperidin-1-yl-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 365 
                 513 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-piperidin-1-yl-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 366 
                 463 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-morpholin-4-yl-acetamide 
               
               
                 367 
                 543 
                 N-(4-{3-[3-Chloro-4-(2-morpholin-4-yl-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 368 
                 515 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-morpholin-4-yl-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 369 
                 414 
                 N-{4-[3-(3-Chloro-4-methanesulfonylamino-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 370 
                 494 
                 N-{4-[3-(3-Chloro-4-methanesulfonylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 371 
                 466 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-methanesulfonylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 372 
                 481 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-(2-dimethy-lamino-ethylsulfanyl)-acetamide 
               
               
                 373 
                 561 
                 N-[4-(3-{3-Chloro-4-[2-(2-dimethylamino-ethylsulfanyl)-acetylamino]-phenyl}-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                 374 
                 585 
                 N-[4-(3-{4-[(1-Benzyl-pyrrolidin-3-yl)-methyl-amino]-3-chloro-phenyl}-thioureido)-phenyl]-2-methyl-benzamide 
               
               
                 375 
                 523 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-2-methyl-benzamide 
               
               
                 376 
                 510 
                 Pyridine-2-carboxylic acid [4-(3-{3-chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 377 
                 347 
                 N-{4-[3-(3-Chloro-4-vinyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                 378 
                 441 
                 Furan-2-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 379 
                 452 
                 Pyridine-2-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 380 
                 487 
                 N-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 381 
                 486 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-cyano-phenyl}-2-fluoro-benzamide 
               
               
                 382 
                 458 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-3-cyano-phenyl}-amide 
               
               
                 383 
                 406 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-cyano-phenyl}-acetamide 
               
               
                 384 
                 395 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-2-methyl-isothioureido]-phenyl}-acetamide 
               
               
                 385 
                 396 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-2-methyl-isothioureido]-phenyl}-acetamide 
               
               
                 386 
                 461 
                 N-{4-[3-(3-Chloro-4-ethylsulfanyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 387 
                 489 
                 N-{4-[3-(4-Butylsulfanyl-3-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 388 
                 411 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methoxy-phenyl}-acetamide 
               
               
                 389 
                 491 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methoxy-phenyl}-2-fluoro-benzamide 
               
               
                 390 
                 463 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-3-methoxy-phenyl}-amide 
               
               
                 391 
                 531 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(2-piperidin-1-yl-acetyl-amino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 392 
                 481 
                 N-{4-[3-(3-Chloro-4-methanesulfinyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 393 
                 497 
                 N-{4-[3-(3-Chloro-4-methanesulfonyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 394 
                 459 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 395 
                 429 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 396 
                 533 
                 Furan-2-carboxylic acid [4-(3-{3-chloro-4-[2-(2-dimethylamino-ethylsulfanyl)-acetylamino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 397 
                 458 
                 N-{4-[3-(4-Acetylamino-3-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 398 
                 460 
                 [2-Chloro-4-(3-{4-[(furan-2-carbonyl)-amino]-phenyl}-thioureido)-phenyl]-carbamic acid ethyl ester 
               
               
                 399 
                 488 
                 (2-Chloro-4-{3-[4-(2-fluoro-benzoylamino)-phenyl]-thioureido}-phenyl)-carbamic acid ethyl ester 
               
               
                 400 
                 440 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-benzamide 
               
               
                 401 
                 520 
                 N-{4-[({[4-(Benzoylamino)-3-chloro-phenyl]-amino}-thioxomethyl)-amino]-phenyl}-2-fluoro-benzamide 
               
               
                 402 
                 529 
                 N-{4-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-2-trifluoromethyl-phenyl}-2-fluoro-benzamide 
               
               
                 403 
                 492 
                 Furan-2-carboxylic acid {4-[3-(4-benzoylamino-3-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 404 
                 416 
                 N-{4-[3-(4-Amino-3-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 405 
                 479 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-thiomorpholin-4-yl-acetamide 
               
               
                 406 
                 531 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-thiomorpholin-4-yl-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 407 
                 559 
                 N-(4-{3-[3-Chloro-4-(2-thiomorpholin-4-yl-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 408 
                 461 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 409 
                 430 
                 Furan-2-carboxylic acid {4-[3-(4-acetylamino-3-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 410 
                 477 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-dipropyl-amino-acetamide 
               
               
                 411 
                 529 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-dipropylamino-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 412 
                 449 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-diethyl-amino-acetamide 
               
               
                 413 
                 501 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-diethylamino-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 414 
                 529 
                 N-(4-{3-[3-Chloro-4-(2-diethylamino-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 415 
                 447 
                 N-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-phenyl}-2-pyrrolidin-1-yl-acetamide 
               
               
                 416 
                 499 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(2-pyrrolidin-1-yl-acetylamino)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 417 
                 527 
                 N-(4-{3-[3-Chloro-4-(2-pyrrolidin-1-yl-acetylamino)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 418 
                 475 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-3-methoxy-phenyl}-2-fluoro-benzamide 
               
               
                 419 
                 445 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]-3-methoxy-phenyl}-2-fluoro-benzamide 
               
               
                 420 
                 477 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-3-methoxy-phenyl}-2-fluoro-benzamide 
               
               
                 421 
                 388 
                 Furan-2-carboxylic acid {4-[3-(4-amino-3-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 422 
                 527 
                 Furan-2-carboxylic acid (4-{3-[4-(2-azepan-1-yl-acetylamino)-3-chloro-phenyl]-thioureido}-phenyl)-amide 
               
               
                 423 
                 555 
                 N-(4-{3-[4-(2-Azepan-1-yl-acetylamino)-3-chloro-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 424 
                 527 
                 Furan-2-carboxylic acid [4-(3-{3-chloro-4-[2-(2-methyl-piperidin-1-yl)-acetyl-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                 425 
                 555 
                 N-[4-(3-{3-Chloro-4-[2-(2-methyl-piperidin-1-yl)-acetylamino]-phenyl}-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                 426 
                 339 
                 Furan-2-carboxylic acid [4-(3-pyridin-2-yl-thioureido)-phenyl]-amide 
               
               
                 427 
                 339 
                 Furan-2-carboxylic acid [4-(3-pyridin-4-yl-thioureido)-phenyl]-amide 
               
               
                 428 
                 367 
                 2-Fluoro-N-[4-(3-pyridin-3-yl-thioureido)-phenyl]-benzamide 
               
               
                 429 
                 339 
                 Furan-2-carboxylic acid [4-(3-pyridin-3-yl-thioureido)-phenyl]-amide 
               
               
                 430 
                 353 
                 Furan-2-carboxylic acid {4-[3-(3-amino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 431 
                 406 
                 Furan-2-carboxylic acid {4-[3-(3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 432 
                 380 
                 2-Fluoro-N-[4-(3-m-tolyl-thioureido)-phenyl]-benzamide 
               
               
                 433 
                 434 
                 2-Fluoro-N-{4-[3-(3-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 434 
                 381 
                 N-{4-[3-(3-Amino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 435 
                 388 
                 Furan-2-carboxylic acid {4-[3-(3-amino-5-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 436 
                 352 
                 Furan-2-carboxylic acid [4-(3-m-tolyl-thioureido)-phenyl]-amide 
               
               
                 437 
                 416 
                 N-{4-[3-(2-Amino-5-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 438 
                 571 
                 (2-Chloro-4-{3-[4-(2-fluoro-benzoylamino)-phenyl]-thioureido}-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester 
               
               
                 439 
                 543 
                 [2-Chloro-4-(3-{4-[(furan-2-carbonyl)-maino]-phenyl}-thioureido)-phenyl]-carbamic acid 2-piperidin-1-yl-ethyl ester 
               
               
                 440 
                 388 
                 Furan-2-carboxylic acid {4-[3-(2-amino-5-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 441 
                 363 
                 Furan-2-carboxylic acid {4-[3-(3-cyano-phenyl)-thioureido]-phenyl}-amide 
               
               
                 442 
                 416 
                 N-{4-[3-(3-Amino-5-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 443 
                 367 
                 2-Fluoro-N-[4-(3-pyridin-2-yl-thioureido)-phenyl]-benzamide 
               
               
                 444 
                 367 
                 2-Fluoro-N-[4-(3-pyridin-4-yl-thioureido)-phenyl]-benzamide 
               
               
                 445 
                 374 
                 Furan-2-carboxylic acid {4-[3-(6-chloro-pyridin-3-yl)-thioureido]-phenyl}-amide 
               
               
                 446 
                 388 
                 Furan-2-carboxylic acid {4-[3-(2-amino-3-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 447 
                 396 
                 Furan-2-carboxylic acid {4-[3-(3-hydrazinocarbonyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 448 
                 410 
                 2-Fluoro-N-(4-{3-[3-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-benzamide 
               
               
                 449 
                 414 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-hydrazinocarbonyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 450 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-isopropyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 451 
                 380 
                 Furan-2-carboxylic acid {4-[3-(3-isopropyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 452 
                 409 
                 2-Fluoro-N-{4-[3-(3-isopropyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 453 
                 381 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-cyano-phenyl)-thioureido]-phenyl}-amide 
               
               
                 454 
                 410 
                 N-{4-[3-(3-Dimethylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 455 
                 381 
                 Furan-2-carboxylic acid {4-[3-(3-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 456 
                 370 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-m-tolyl-thioureido)-phenyl]-amide 
               
               
                 457 
                 424 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 458 
                 479 
                 N-{3-Chloro-4-[3-(5-chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 459 
                 449 
                 N-{3-Chloro-4-[3-(3-chloro-4-methyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 460 
                 481 
                 N-{3-Chloro-4-[3-(3-chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 461 
                 391 
                 N-{4-[3-(3-Cyano-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 462 
                 395 
                 Furan-2-carboxylic acid {4-[3-(3-acetylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 463 
                 424 
                 2-Fluoro-N-{4-[3-(3-hydrazinocarbonyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 464 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3 (1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 465 
                 434 
                 N-{4-[3-(2-Amino-3-chloro-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 466 
                 406 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-amino-5-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 467 
                 398 
                 Furan-2-carboxylic acid {4-[3-(3,5-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 468 
                 416 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 469 
                 454 
                 5-(3-{4-[(Furan-2-carbonyl)-amino]-phenyl}-thioureido)-isophthalic acid dimethyl ester 
               
               
                 470 
                 434 
                 Isoxazole-5-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 471 
                 392 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(6-chloro-pyridin-3-yl)-thioureido]-phenyl}-amide 
               
               
                 472 
                 382 
                 Furan-2-carboxylic acid (4-{3-[3-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-amide 
               
               
                 473 
                 368 
                 Furan-2-carboxylic acid {4-[3-(3-methoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 474 
                 354 
                 Furan-2-carboxylic acid {4-[3-(3-hydroxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 475 
                 382 
                 2-Fluoro-N-{4-[3-(3-hydroxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 476 
                 396 
                 2-Fluoro-N-{4-[3-(3-hydroxymethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 477 
                 423 
                 N-{4-[3-(3-Acetylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 478 
                 413 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-acetylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 479 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3 dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 480 
                 340 
                 Furan-2-carboxylic acid [4-(3-pyrimidin-4-yl-thioureido)-phenyl]-amide 
               
               
                 481 
                 378 
                 Furan-2-carboxylic acid {4-[3-(1H-indazol-5-yl)-thioureido]-phenyl}-amide 
               
               
                 482 
                 395 
                 Furan-2-carboxylic acid [4-(3-benzothiazol-5-yl-thioureido)-phenyl]-amide 
               
               
                 483 
                 406 
                 2-Fluoro-N-{4-[3-(1H-indazol-5-yl)-thioureido]-phenyl}-benzamide 
               
               
                 484 
                 424 
                 N-[4-(3-Benzothiazol-5-yl-thioureido)-phenyl]-2-fluoro benzamide 
               
               
                 485 
                 473 
                 5-(3-{4-[([1,2,3]Thiadiazole-4-carbonyl)-amino]-phenyl}-thioureido)-isophthalic acid dimethyl ester 
               
               
                 486 
                 442 
                 Furan-2-carboxylic acid (4-{3-[4-(1-azido-ethyl)-3-chloro-phenyl]-thioureido}-phenyl)-amide 
               
               
                 487 
                 396 
                 2-Fluoro-N-{4-[3-(3-methoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 488 
                 368 
                 Furan-2-carboxylic acid {4-[3-(3-hydroxymethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 489 
                 416 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 490 
                 444 
                 N-{4-[3-(5-Chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 491 
                 506 
                 [3-Chloro-5-(3-{4-[([1,2,3]thiadiazole-4-carbonyl)-amino]-phenyl}-thioureido)-phenyl]-carbamic acid tert-butyl ester 
               
               
                 492 
                 470 
                 N-(4-{3-[4-(1-Azido-ethyl)-3-chloro-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 493 
                 337 
                 Furan-2-carboxylic acid [4-(1H-thiazolo[5,4-b]pyridin-2-ylideneamino)-phenyl]-amide 
               
               
                 494 
                 378 
                 Furan-2-carboxylic acid {4-[3-(1H-benzoimidazol-5-yl)-thioureido]-phenyl}-amide 
               
               
                 495 
                 392 
                 Furan-2-carboxylic acid {4-[3-(2-methyl-1H-benzoimidazol-5-yl)-thioureido]-phenyl}-amide 
               
               
                 496 
                 406 
                 N-{4-[3-(1H-Benzoimidazol-5-yl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 497 
                 420 
                 2-Fluoro-N-{4-[3-(2-methyl-1H-benzoimidazol-5-yl)-thioureido]-phenyl}-benzamide 
               
               
                 498 
                 452 
                 [1,2,3]Thiadiazole-4-carboxylic acid {5-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-2-yl}-amide 
               
               
                 499 
                 445 
                 Pyridine-2-carboxylic acid {5-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-2-yl}-amide 
               
               
                 500 
                 434 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 501 
                 484 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[4-(2-amino-pyrimidin-4-yl)-3-chloro-phenyl]-thioureido}-phenyl)-amide 
               
               
                 502 
                 494 
                 N-(4-{3-[4-(2-Amino-pyrimidin-4-yl)-3-chloro-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 503 
                 434 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 504 
                 462 
                 N-{4-[3-(3-Chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 505 
                 416 
                 Furan-2-carboxylic acid (4-[3-(3-chloro-2-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 506 
                 445 
                 Pyridine-2-carboxylic acid {6-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-3-yl}-amide 
               
               
                 507 
                 462 
                 N-{6-[3-(5-Chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-3-yl}-2-fluoro-benzamide 
               
               
                 508 
                 482 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-iodo-phenyl)-thioureido]-phenyl}-amide 
               
               
                 509 
                 413 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-tert-butyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 510 
                 387 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 511 
                 415 
                 N-{4-[3-(3-Chloro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 512 
                 434 
                 Furan-2-carboxylic acid {6-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-3-yl}-amide 
               
               
                 513 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo-phenyl)-thioureido]-phenyl}-amide 
               
               
                 514 
                 452 
                 [1,2,3]Thiadiazole-4-carboxylic acid {6-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-pyridin-3-yl}-amide 
               
               
                 515 
                 426 
                 [1,2,3]Thiadiazole-4-carboxylic acid {5-[3-(3,5-dichloro-phenyl)-thioureido]-pyridin-2-yl}-amide 
               
               
                 516 
                 474 
                 Furan-2-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 517 
                 502 
                 N-{4-[3-(3,5-Bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-2-Fluoro-Benzamide 
               
               
                 518 
                 450 
                 N-{4-[3-(4-Amino-3,5-dichloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 519 
                 539 
                 N-{4-[3-(4-Amino-3,5-dibromo-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 520 
                 392 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-pyridin-3-yl)-thioureido]-phenyl}-amide 
               
               
                 521 
                 529 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-amino-3,5-dibromo-phenyl)-thioureido]-phenyl}-amide 
               
               
                 522 
                 434 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-5-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 523 
                 444 
                 N-{4-[3-(3-Chloro-5-dimethylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 524 
                 416 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-5-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                 525 
                 436 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-bromo-pyridin-3-yl)-thioureido]-phenyl}-amide 
               
               
                 526 
                 379 
                 Furan-2-carboxylic acid {4-[3-(1H-benzotriazol-5-yl)-thioureido]-phenyl}-amide 
               
               
                 527 
                 425 
                 N-{4-[3-(1H-Benzotriazol-5-yl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                 528 
                 388 
                 N-[4-({[2-(3-Chloro-phenyl)-hydrazino]-thioxomethyl}-amino)-phenyl]-furan-2-carboxamide 
               
               
                 529 
                 416 
                 N-[4-({[2-(3-Chloro-phenyl)-hydrazino]-thioxomethyl}-amino)-phenyl]-2-fluoro-benzamide 
               
               
                 530 
                 456 
                 Furan-2-carboxylic acid {4-[3-(2-amino-3-chloro-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 531 
                 513 
                 N-{4-[3-(3-Bromo-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 532 
                 503 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 533 
                 374 
                 {4-[(Furan-2-carbonyl)-amino]-phenyl}-thiocarbamic acid ( )-(3-chloro-phenyl) ester 
               
               
                 534 
                 474 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-amino-3-chloro-5-trifluoro-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 535 
                 508 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-piperidin-1-yl-5-trifluoro-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 536 
                 380 
                 N-[4-(3-Benzyl-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                 537 
                 439 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 538 
                 449 
                 N-{4-[3-(3,4-Dichloro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 539 
                 370 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-benzyl-thioureido)-phenyl]-amide 
               
               
                 540 
                 424 
                 N-[4-(3-Benzo[1,3]dioxol-5-ylmethyl-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                 541 
                 414 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-benzo[1,3]dioxol-5-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 542 
                 506 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 543 
                 516 
                 N-{4-[3-(3,5-Bis-trifluoromethyl-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 544 
                 352 
                 Furan-2-carboxylic acid [4-(3-benzyl-thioureido)-phenyl]-amide 
               
               
                 545 
                 421 
                 Furan-2-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 546 
                 396 
                 Furan-2-carboxylic acid [4-(3-benzo[1,3]dioxol-5-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 547 
                 488 
                 Furan-2-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 548 
                 503 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-[3-(4-bromo-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 549 
                 529 
                 N-{4-[3-(3-Bromo-4-trifluoromethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 550 
                 519 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-bromo4-trifluoromethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                 551 
                 473 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-trifluoromethylsulfanyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 552 
                 412 
                 2-Fluoro-N-(4-{3-[2-(3-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 553 
                 412 
                 2-Fluoro-N-(4-{3-[2-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 554 
                 402 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 555 
                 402 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 556 
                 495 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(2-methyl-butyl)-5-trifluoro-methyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 557 
                 481 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-[3-(3-isobutyl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 558 
                 523 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(4-methyl-piperazin-1-yl)-5-trifluoro-methyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 559 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-morpholin-4-yl-5-trifluoro-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 560 
                 494 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-pyrrolidin-1-yl-5-trifluoro-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 561 
                 384 
                 Furan-2-carboxylic acid (4-{3-[2-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 562 
                 419 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 563 
                 429 
                 N-(4-{3-[2-(3-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 564 
                 401 
                 Furan-2-carboxylic acid (4-{3-[2-(3-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 565 
                 402 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-theyl]-thioureido}-phenyl)-amide 
               
               
                 566 
                 504 
                 2-Fluoro-N-{4-[3-(3-pyrrolidin-1-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 567 
                 477 
                 N-{4-[3-(3-Dimethylamino-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 568 
                 520 
                 2-Fluoro-N-{4-[3-(3-morpholin-4-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 569 
                 533 
                 2-Fluoro-N-(4-{3-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-benzamide 
               
               
                 570 
                 518 
                 2-Fluoro-N-{4-[3-(3-piperidin-1-yl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 571 
                 468 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-dimethylamino-5-trifluoro-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 572 
                 405 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 573 
                 384 
                 Furan-2-carboxylic acid (4-{3-[2-(3-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 574 
                 366 
                 Furan-2-carboxylic acid [4-(3-phenethyl-thioureido)-phenyl]-amide 
               
               
                 575 
                 384 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-phenethyl-thioureido)-phenyl]-amide 
               
               
                 576 
                 394 
                 2-Fluoro-N-[4-(3-phenethyl-thioureido)-phenyl]-benzamide 
               
               
                 577 
                 505 
                 2-Fluoro-N-(4-{3-[3-(2-methyl-butyl)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-benzamide 
               
               
                 578 
                 491 
                 2-Fluoro-N-{4-[3-(3-isobutyl-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 579 
                 388 
                 Furan-2-carboxylic acid {4-[3-(3,5-difluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 580 
                 416 
                 N-{4-[3-(3,5-Difluoro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 581 
                 406 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-difluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 582 
                 421 
                 Furan-2-carboxylic acid {4-[3-(3,5-dichloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 583 
                 449 
                 N-{4-[3-(3,5-Dichloro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 584 
                 439 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 585 
                 438 
                 Furan-2-carboxylic acid {4-[3-(3-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 586 
                 466 
                 2-Fluoro-N-{4-[3-(3-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-benzamide 
               
               
                 587 
                 456 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 588 
                 384 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(1-phenyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 589 
                 394 
                 2-Fluoro-N-{4-[3-(1-phenyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 590 
                 366 
                 Furan-2-carboxylic acid {4-[3-(1-phenyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 591 
                 412 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 592 
                 384 
                 Furan-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 593 
                 413 
                 N-{4-[3-(1-tert-Butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 594 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(isobutyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 595 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(3-hydroxy-pyrrolidin-1-yl)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 596 
                 520 
                 2-Fluoro-N-(4-{3-[3-(isobutyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-benzamide 
               
               
                 597 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(butyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 598 
                 520 
                 N-(4-{3-[3-(Butyl-methyl-amino)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 599 
                 520 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 600 
                 442 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 601 
                 522 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-[3-(4-piperidin-1-yl-3-trifluoro-methyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 602 
                 482 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-dimethylamino-3-trifluoro-methyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 603 
                 381 
                 Furan-2-carboxylic acid (4-{3-[2-(4-amino-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 604 
                 445 
                 Furan-2-carboxylic acid (4-{3-[2-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 605 
                 380 
                 Furan-2-carboxylic acid {4-[3-(2-p-tolyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 606 
                 463 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 607 
                 396 
                 Furan-2-carboxylic acid (4-{3-[2-(3-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 608 
                 403 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(1-tert-butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-amide 
               
               
                 609 
                 384 
                 Furan-2-carboxylic acid {4-[3-(1-tert-butyl-1H-imidazol-2-yl)-thioureido]-phenyl}-amide 
               
               
                 610 
                 492 
                 N-{4-[3-(4-Dimethylamino-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 611 
                 427 
                 Furan-2-carboxylic acid (4-{3-[2-(3,4-dimethoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 612 
                 380 
                 Furan-2-carboxylic acid {4-[3-(3-phenyl-propyl)-thioureido]-phenyl}-amide 
               
               
                 613 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-phenyl-propyl)-thioureido]-phenyl}-amide 
               
               
                 614 
                 502 
                 Furan-2-carboxylic acid (4-{3-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 615 
                 550 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-iodo-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 616 
                 532 
                 2-Fluoro-N-{4-[3-(4-piperidin-1-yl-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-benzamide 
               
               
                 617 
                 537 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[4-(4-methyl-piperazin-1-yl)-3-trifluoromethyl-benzyl]-thioureido}-phenyl)-amide 
               
               
                 618 
                 482 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-dimethylamino-5-trifluoro-methyl-benzyl)-thioureido]-phenyl}amide 
               
               
                 619 
                 488 
                 Furan-2-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido-methyl]-phenyl}-amide 
               
               
                 620 
                 421 
                 Furan-2-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureidomethyl]-phenyl}-amide 
               
               
                 621 
                 421 
                 Furan-2-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureidomethyl]-phenyl}-amide 
               
               
                 622 
                 455 
                 Furan-2-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido-methyl]-phenyl}-amide 
               
               
                 623 
                 466 
                 2-Fluoro-N-{4-[3-(4-fluoro-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-benzamide 
               
               
                 624 
                 456 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 625 
                 410 
                 2-Fluoro-N-{4-[3-(2-phenoxy-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 626 
                 382 
                 Furan-2-carboxylic acid {4-[3-(2-phenoxy-ethyl)-thioureido]-phenyl}-amide 
               
               
                 627 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-phenoxy-ethyl)-thioureido]-phenyl}-amide 
               
               
                 628 
                 409 
                 2-Fluoro-N-{4-[3-(3-phenyl-propyl)-thioureido]-phenyl}-benzamide 
               
               
                 629 
                 425 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-trifluoromethyl-pyridin-3-yl)-thioureido]-phenyl}-amide 
               
               
                 630 
                 439 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido-methyl]-phenyl}-amide 
               
               
                 631 
                 473 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureidomethyl]-phenyl}-amide 
               
               
                 632 
                 381 
                 2-Fluoro-N-[4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-benzamide 
               
               
                 633 
                 353 
                 Furan-2-carboxylic acid [4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 634 
                 371 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-pyridin-3-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 635 
                 439 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido-methyl]-phenyl}-amide 
               
               
                 636 
                 492 
                 N-{4-[3-(3-Dimethylamino-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 637 
                 415 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 638 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-p-tolyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 639 
                 445 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dimethoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 640 
                 506 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureidomethyl]-phenyl}-amide 
               
               
                 641 
                 516 
                 N-{4-[3-(3,5-Bis-trifluoromethyl-phenyl)-thioureidomethyl]-phenyl}-2-fluoro-benzamide 
               
               
                 642 
                 449 
                 N-{4-[3-(3,5-Dichloro-phenyl)-thioureidomethyl]-phenyl}-2-fluoro-benzamide 
               
               
                 643 
                 449 
                 N-{4-[3-(3,4-Dichloro-phenyl)-thioureidomethyl]-phenyl}-2-fluoro-benzamide 
               
               
                 644 
                 448 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-acetylamino-5-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 645 
                 453 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 646 
                 413 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(1-methyl-3-phenyl-propyl)-thioureido]-phenyl}-amide 
               
               
                 647 
                 463 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 648 
                 413 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-phenyl-butyl)-thioureido]-phenyl}-amide 
               
               
                 649 
                 397 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-indan-1-yl-thioureido)-phenyl]-amide 
               
               
                 650 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-methoxy-benzyl)-thioureido]-phenyl}-amide 
               
               
                 651 
                 415 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 652 
                 415 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 653 
                 506 
                 N-(4-{3-[2-(3-Dimethylamino-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 654 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-(3-dimethylamino-propyl)-5-trifluoromethyl-phenyl]-thioureido}-phenyl)-amide 
               
               
                 655 
                 417 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-phenylsulfanyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 656 
                 427 
                 2-Fluoro-N-{4-[3-(2-phenylsulfanyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 657 
                 399 
                 Furan-2-carboxylic acid {4-[3-(2-phenylsulfanyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 658 
                 381 
                 2-Fluoro-N-[4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-benzamide 
               
               
                 659 
                 353 
                 Furan-2-carboxylic acid [4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 660 
                 371 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-pyridin-4-ylmethyl-thioureido)-phenyl]-amide 
               
               
                 661 
                 506 
                 2-Fluoro-N-{4-[3-(3-iodo-benzyl)-thioureido]-phenyl}benzamide 
               
               
                 662 
                 478 
                 Furan-2-carboxylic acid {4-[3-(3-iodo-benzyl)-thioureido]-phenyl}-amide 
               
               
                 663 
                 496 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-iodo-benzyl)-thioureido]-phenyl}-amide 
               
               
                 664 
                 479 
                 N-(4-{3-[2-(3,5-Dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 665 
                 451 
                 Furan-2-carboxylic acid (4-{3-[2-(3,5-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 666 
                 445 
                 N-(4-{3-[2-(3-Chloro-phenoxy)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 667 
                 417 
                 Furan-2-carboxylic acid (4-{3-[2-(3-chloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 668 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-chloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 669 
                 466 
                 2-Fluoro-N-{4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-benzamide 
               
               
                 670 
                 438 
                 Furan-2-carboxylic acid {4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 671 
                 456 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 672 
                 416 
                 N-{4-[3-(3,4-Difluoro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 673 
                 452 
                 N-(4-{3-[2-(4-Dimethylamino-3-methyl-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 674 
                 496 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-dimethylamino-5-trifluoro-methyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 675 
                 388 
                 Furan-2-carboxylic acid {4-[3-(3,4-difluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 676 
                 406 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-difluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 677 
                 433 
                 N-{4-[3-(3-Chloro-4-fluoro-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 678 
                 495 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 679 
                 477 
                 Furan-2-carboxylic acid (4-{3-[2-(3-bromo-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 680 
                 505 
                 N-(4-{3-[2-(3-Bromo-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 681 
                 493 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-4-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 682 
                 493 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-ihioureido}-phenyl)-amide 
               
               
                 683 
                 419 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 684 
                 402 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 685 
                 419 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[22(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 686 
                 475 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,3-diphenyl-propyl)-thioureido]-phenyl}-amide 
               
               
                 687 
                 547 
                 2-Fluoro-N-(4-{3-[4-(4-methyl-piperazin-1-yl)-3-trifluoromethyl-benzyl]-thioureido}-phenyl)-benzamide 
               
               
                 688 
                 469 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 689 
                 423 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-fluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 690 
                 427 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-tert-butyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 691 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dimethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 692 
                 442 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-dimethylamino-3-methyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 693 
                 479 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-bromo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 694 
                 526 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-iodo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 695 
                 489 
                 N-(4-{3-[2-(4-Bromo-phenoxy)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 696 
                 536 
                 2-Fluoro-N-(4-{3-[2-(4-iodo-phenoxy)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 697 
                 461 
                 Furan-2-carboxylic acid (4-{3-[2-(4-bromo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 698 
                 508 
                 Furan-2-carboxylic acid (4-{3-[2-(4-iodo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 699 
                 408 
                 Oxazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 700 
                 424 
                 Thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 701 
                 491 
                 Thiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 702 
                 408 
                 Oxazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 703 
                 469 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 704 
                 424 
                 Thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 705 
                 458 
                 Thiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 706 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-phenylamino-ethyl)-thioureido]-phenyl}-amide 
               
               
                 707 
                 453 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2,4-dichloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 708 
                 452 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 709 
                 453 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2,6-dichloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 710 
                 485 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 711 
                 503 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenylsulfanyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 712 
                 668 
                 N-(4-{3-[3-Chloro-5-(3-{4-[([1,2,3]thiadiazole-4-carbonyl)-amino]-phenyl}-thioureido)-phenyl]-thioureido}-phenyl)- 
               
               
                   
                   
                 [1,2,3]thiadiazole-4-carboxamide 
               
               
                 713 
                 413 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-ethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 714 
                 442 
                 Oxazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 715 
                 475 
                 Oxazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 716 
                 420 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,4-difluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 717 
                 452 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 718 
                 435 
                 Furan-2-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-ethyl]-thioureido]-phenyl)-amide 
               
               
                 719 
                 463 
                 N-(4-{3-[2-(3,4-Dichloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 720 
                 420 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3,5-difluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 721 
                 412 
                 2-fluoro-N-(4-{3-[2-(2-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 722 
                 429 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-nitro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 723 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(1-methyl-2-phenyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 724 
                 437 
                 N-{4-[3-(4-tert-Butyl-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 725 
                 409 
                 N-{4-[3-(3,5-Dimethyl-benzyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 726 
                 400 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-hydroxy-1-phenyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 727 
                 409 
                 2-Fluoro-N-{4-[3-(1-methyl-1-phenyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 728 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(1-methyl-1-phenyl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 729 
                 405 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-chloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 730 
                 388 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(2-fluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 731 
                 438 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 732 
                 388 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-fluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 733 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-chloro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 734 
                 479 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 735 
                 418 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 736 
                 418 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 737 
                 486 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 738 
                 384 
                 Furan-2-carboxylic acid (4-{3-[2-(2-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 739 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-phenyl)-thioureido]-phenyl}-amide 
               
               
                 740 
                 374 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-fluoro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 741 
                 388 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-[3-(4-fluoro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 742 
                 405 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 743 
                 449 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-benzyl)-thioureido]-phenyl}-amide 
               
               
                 744 
                 332 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-acetamide 
               
               
                 745 
                 438 
                 Thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-benzyl)-thioureido]-phenyl}-amide 
               
               
                 746 
                 455 
                 Thiazole-4-carboxylic acid {4-[3-(2-fluoro-5-trifluoromethyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 747 
                 426 
                 Thiazole-4-carboxylic acid {4-[3-(4-tert-butyl-benzyl)-thioureido]-phenyl}-amide 
               
               
                 748 
                 374 
                 [1,2,3]Thiazole-4-carboxylic acid {4-[3-(2-fluoro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 749 
                 374 
                 [1,2,3]Thiazole-4-carboxylic acid {4-[3-(3-fluoro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 750 
                 526 
                 [1,2,3]Thiazole-4-carboxylic acid (4-{3-[2-(3-iodo-phenoxy)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 751 
                 409 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-phenyl-acetamide 
               
               
                 752 
                 425 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-methoxy-benzamide 
               
               
                 753 
                 425 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-3-methoxy-benzamide 
               
               
                 754 
                 425 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-4-methoxy-benzamide 
               
               
                 755 
                 429 
                 2-Chloro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 756 
                 429 
                 4-Chloro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 757 
                 453 
                 Acetic acid 4-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-carbamoyl)-phenyl ester 
               
               
                 758 
                 394 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 759 
                 395 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-isonicotinamide 
               
               
                 760 
                 410 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-4-hydroxy-benzamide 
               
               
                 761 
                 429 
                 3-Chloro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 762 
                 470 
                 [1,2,3]Thiazole-4-carboxylic acid (4-{3-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 763 
                 520 
                 [1,2,3]Thiazole-4-carboxylic acid (4-{3-[2-(2,4-bis-fluoro-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 764 
                 470 
                 [1,2,3]Thiazole-4-carboxylic acid (4-{3-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 765 
                 438 
                 4-Dimethylamino-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 766 
                 470 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 767 
                 470 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(2-fluoro-5-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 768 
                 510 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-iodo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 769 
                 470 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(4-fluoro-2-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 770 
                 463 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[2-(3-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 771 
                 427 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-propyl]-thioureido}-phenyl)-benzamide 
               
               
                 772 
                 475 
                 2-Fluoro-N-(4-{3-[(4-fluoro-phenyl)-phenyl-methyl]-thioureido}-phenyl)-benzamide 
               
               
                 773 
                 455 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-pentyl]-thioureido}-phenyl)-benzamide 
               
               
                 774 
                 489 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-2-phenyl-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 775 
                 409 
                 2-Fluoro-N-{4-[3-(1-o-tolyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 776 
                 409 
                 2-Fluoro-N-{4-[3-(1-m-tolyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 777 
                 425 
                 2-Fluoro-N-(4-{3-[1-(4-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 778 
                 412 
                 2-Fluoro-N-(4-{3-[1-(2-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 779 
                 429 
                 N-(4-{3-[1-(3-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 780 
                 473 
                 N-(4 {3-[1-(3-Bromo-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 781 
                 429 
                 N-(4-{3-[1-(4-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 782 
                 409 
                 2-Fluoro-N-{4-[3-(1-p-tolyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 783 
                 473 
                 N-(4-{3-[1-(2-Bromo-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 784 
                 429 
                 N-(4-{3-[1-(2-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 785 
                 462 
                 2-Fluoro-N-(4-{3-[1-(2-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 786 
                 462 
                 2-Fluoro-N-(4-{3-[1-(3-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 787 
                 462 
                 2-Fluoro-N-(4-{3-[1-(4-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 788 
                 425 
                 2-Fluoro-N-(4-{3-[1-(2-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 789 
                 425 
                 2-Fluoro-N-(4-{3-[1-(3-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 790 
                 441 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-2-methyl-propyl]-thioureido}-phenyl)-benzamide 
               
               
                 791 
                 419 
                 N-(4-{3-[1-(3-Cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 792 
                 419 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 793 
                 438 
                 N-(4-{3-[1-(4-Dimethylamino-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 794 
                 438 
                 N-(4-{3-[1-(3-Dimethylamino-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 795 
                 473 
                 2-Bromo-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 796 
                 446 
                 Quinoline-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 797 
                 410 
                 2-Fluoro-N-{4-[3-(2-hydroxy-1-phenyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 798 
                 332 
                 2-Fluoro-N-[4-(3-isopropyl-thioureido)-phenyl]-benzamide 
               
               
                 799 
                 445 
                 2-Fluoro-N-{4-[3-(1-naphthalene-2-yl-ethyl)-thioureido}-phenyl}-benzamide 
               
               
                 800 
                 412 
                 3-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 801 
                 412 
                 4-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 802 
                 384 
                 2-Fluoro-N-{4-[3-(1-furan-2-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 803 
                 395 
                 2-Fluoro-N-{4-[3-(1-pyridin-4-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 804 
                 397 
                 2-Fluoro-N-(4-{3-[1-(1-methyl-1H-pyrrol-2-yl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 805 
                 401 
                 2-Fluoro-N-{4-[3-(1-thiophen-3-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 806 
                 445 
                 N-{4-[3-(3-Chloro-4-ethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 807 
                 459 
                 N-{4-[3-(3-Chloro-4-propoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 808 
                 459 
                 N-{4-[3-(3-Chloro-4-isopropoxy-phenyl)-thioureido]-phenyl}-2-fluoro-Benzamide 
               
               
                 809 
                 473 
                 N-{4-[3-(4-Butoxy-3-chloro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 810 
                 522 
                 2-Fluoro-N-{4-[3-(3-iodo-4-methoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 811 
                 475 
                 N-{4-[3-(3-Bromo-4-methoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 812 
                 520 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-iodo-benzamide 
               
               
                 813 
                 346 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-propionamide 
               
               
                 814 
                 286 
                 N-[4-(3-Phenyl-thioureido)-phenyl]-acetamide 
               
               
                 815 
                 463 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1S)-1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 816 
                 463 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1R)-1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 818 
                 520 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 820 
                 418 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1S)-1-(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 821 
                 418 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[(1R)-1-(4-chloro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 822 
                 409 
                 N-[4-[[[[1-(4-Cyanophenyl)ethyl]amino]thioxomethyl]amino]phenyl]-1,2,3-thiadiazole-4-carboxamide 
               
               
                 824 
                 462 
                 Thiazole-4-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 825 
                 520 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-(1S)-[1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 828 
                 470 
                 N-(4-{[({1-[4-fluoro-3-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide 
               
               
                 829 
                 486 
                 N-(4-{[({1-[4-chloro-3-hiadiazole-4-carboxamide 
               
               
                 830 
                 519 
                 N-(4-{[({(1S)-1-[3,5-thiazole-4-carboxamide 
               
               
                 831 
                 469 
                 N-(4-{[({1-[3-fluoro-5-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 832 
                 469 
                 N-(4-{[({1-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 833 
                 469 
                 N-(4-{[({1-[2-fluoro-5-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 834 
                 519 
                 N-(4-{[({1-[2,4-bis(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 834 
                 411 
                 N-{4-[({[1-(2,4-dimethylphenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 836 
                 452 
                 N-{4-[({[1-(2,4-dichlorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 837 
                 397 
                 N-{4-[({[1-(3-methylphenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 838 
                 469 
                 N-(4-{[({1-[4-fluoro-3-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 839 
                 435 
                 N-{4-[({[1-(2-chloro-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 840 
                 419 
                 N-{4-[({[1-(3,4-difluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 841 
                 480 
                 N-{4-[({[1-(4-bromo-2-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 842 
                 401 
                 N-{4-[({[1-(3-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 843 
                 462 
                 N-{4-[({[1-(2-bromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 844 
                 462 
                 N-{4-[({[1-(3-bromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 845 
                 451 
                 N-(4-{[({1-[2-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 846 
                 419 
                 N-{4-[({[1-(2,4-difluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 847 
                 519 
                 N-(4-{[({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 848 
                 452 
                 N-{4-[({[1-(3,4-dichlorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 849 
                 469 
                 N-(4-{[({1-[3-fluoro-4-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 850 
                 485 
                 N-(4-{[({1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 851 
                 435 
                 N-{4-[({[1-(4-chloro-2-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 852 
                 469 
                 N-(4-{[({1-[4-fluoro-2-trifluoromethyl)phenyl]ethyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                 853 
                 435 
                 N-{4-[({[1-(4-chloro-3-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 854 
                 480 
                 N-{4-[({[1-(2-bromo-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 855 
                 541 
                 N-{4-[({[1-(3,4-dibromophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 856 
                 435 
                 N-{4-[({[1-(3-chloro-4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide 
               
               
                 857 
                 366 
                 N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]propyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide 
               
               
                 858 
                 392 
                 N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]butyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide 
               
               
                 859 
                 330 
                 N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]pentyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide 
               
               
                 860 
                 521 
                 N-{4-[({[[3,5-bis(trifluoromethyl)phenyl](phenyl)methyl]amino}carbothioyl)amino]phenyl}-1,2,3-thiadiazole-4-carboxamide 
               
               
                 861 
                 450 
                 N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]-1-methylethyl}amino)carbothioyl]amino}phenyl)-1,2,3-thiadiazole-4-carboxamide 
               
               
                 862 
                 433 
                 N-{4-[({[3,5-bis(trifluoromethyl)benzyl]amino}carbothioyl)amino]phenyl}-1H-imidazole-4-carboxamide 
               
               
                 863 
                 440 
                 N-{4-[({[1-(4-fluorophenyl)ethyl]amino}carbothioyl)amino]phenyl}-1H-imidazole-4-carboxamide 
               
               
                 864 
                 506 
                 N-{4-[({[3,5-bis(trifluoromethyl)benzyl]amino}carbothioyl)amino]phenyl}-1-methyl-1H-imidazole-4-carboxamide 
               
               
                 865 
                 462 
                 N-(4-{[({1-[3,5-bis(trifluoromethyl)phenyl]propyl}amino)carbothioyl]amino}phenyl)-1,3-thiazole-4-carboxamide 
               
               
                   
               
             
          
         
       
     
     EXAMPLE 866 (METHOD 32) 
     [1,2,3,]Thiadiazole-4-carboxylic acid {4-[3-(2,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
     To a solution of 2,5-dichloroaniline (0.16 g) in tetrahydrofuran (20 mL) is added freshly prepared 1,1′-thiocarbonyldiimidazole (0.20 g) and the mixture is stirred for approximately 30 minutes at room temperature. [1,2,3]-Thiadiazole-4-carboxylic acid (4-amino-phenyl) amide (0.22 g) is added to the reaction flask and the mixture is stirred for approximately 6 hours. The solvent is then removed by evaporation under reduced pressure and warm acetonitrile (3 mL) is added. After 15 hours the mixture is filtered and the collected precipitate is washed with acetonitrile then diethyl ether, and air dried to provide the desired product as a white powder. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     
       
         
               
               
               
             
           
               
                   
               
               
                 EX 
                   
                   
               
               
                 NO. 
                 M + H 
                 COMPOUND NAME 
               
               
                   
               
             
             
               
                  867 
                 321 
                 N-{4-[3-(3-Chloro-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  868 
                 413 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                  869 
                 443 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-2-methoxy-benzamide 
               
               
                  870 
                 443 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-3-methoxy-benzamide 
               
               
                  871 
                 443 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-4-methoxy-benzamide 
               
               
                  872 
                 431 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-4 methoxy-benzamide 
               
               
                  873 
                 431 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-3-fluoro-benzamide 
               
               
                  874 
                 431 
                 N-{4-[3-(3-Chloro-4-methoxy-phenyl)-thioureido]-phenyl}-4-fluoro-benzamide 
               
               
                  875 
                 437 
                 Furan-2-carboxylic acid {4-[3-(3,5-dichloro-4-methoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                  876 
                 511 
                 {4-[3-(5-Bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-carbamic acid hexyl ester 
               
               
                  877 
                 481 
                 Hexanoic acid {4-[3-(5-bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                  878 
                 505 
                 N-{4-[3-(5-Bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                  879 
                 477 
                 Furan-2-carboxylic acid {4-[3-(5-bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                  880 
                 501 
                 N-{4-[3-(5-Bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                  881 
                 517 
                 N-{4-[3-(5-Bromo-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-4-methoxy-benzamide 
               
               
                  882 
                 395 
                 N-{4-[3-(5-Chloro-2-ethoxy-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  883 
                 395 
                 N-{4-[3-(5-Chloro-4-ethoxy-2-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  884 
                 423 
                 N-{4-[3-(2-Butoxy-5-chloro-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  885 
                 423 
                 N-{4-[3-(4-Butoxy-5-chloro-2-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  886 
                 457 
                 N-{4-[3-(2-Benzyloxy-5-chloro-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  887 
                 457 
                 N-{4-[3-(4-Benzyloxy-5-chloro-2-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  888 
                 421 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-methoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                  889 
                 424 
                 2-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro-5-methoxy-phenoxy}-acetamide 
               
               
                  890 
                 367 
                 N-{4-[3-(5-Chloro-2-hydroxy-4-methoxy-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  891 
                 367 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-acetamide 
               
               
                  892 
                 447 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                  893 
                 426 
                 N-(4-{3-[3-Chloro-4-(methyl-phenyl-amino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                  894 
                 509 
                 N-[4-(3-{4-[(1-Benzyl-pyrrolidin-3-yl)-methyl-amino]-3-chloro-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                  895 
                 418 
                 N-[4-{3-[3-Chloro-4-(cyclopentyl-methyl-amino)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                  896 
                 433 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-phenyl}-thioureido)-phenyl]-acetamide 
               
               
                  897 
                 419 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                  898 
                 447 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                  899 
                 465 
                 N-{4-[3-(3-Chloro-4-methylsulfanyl-phenyl)-thioureido]-phenyl}-2,6-difluoro-benzamide 
               
               
                  900 
                 445 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                  901 
                 441 
                 N-{4-[3-(5-Chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-2-methyl-benzamide 
               
               
                  902 
                 434 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-amide 
               
               
                  903 
                 444 
                 N-{4-[3-(3-Chloro-4-dimethylamino-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                  904 
                 517 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-{3-chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-amide 
               
               
                  905 
                 579 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-{4-[(1-benzyl-pyrrolidin-3-yl)-methyl-amino]-3-chloro-phenyl}-thioureido)-phenyl]-amide 
               
               
                  906 
                 527 
                 N-[4-(3-{3-Chloro-4-[methyl-(1-methyl-piperidin-4-yl)-amino]-phenyl}-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                  907 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(5-chloro-2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                  908 
                 589 
                 N-[4-(3-{4-[(1-Benzyl-pyrrolidin-3-yl)-methyl-amino]-3-chloro-phenyl}-thioureido)-phenyl]-2-fluoro-benzamide 
               
               
                  909 
                 501 
                 Furan-2-carboxylic acid {4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-3-trifluoromethyl-phenyl]-amide 
               
               
                  910 
                 366 
                 2-Fluoro-N-[4-(3-phenyl-thioureido)-phenyl]-benzamide 
               
               
                  911 
                 338 
                 Furan-2-carboxylic acid [4-(3-phenyl-thioureido)-phenyl]-amide 
               
               
                  912 
                 356 
                 [1,2,3]Thiadiazole-4-carboxylic acid [4-(3-phenyl-thioureido)-phenyl]-amide 
               
               
                  913 
                 365 
                 N-(4-{3-[3-Chloro-4-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                  914 
                 435 
                 [1,2,3]Thiadiazole-4-carboxylic acid (4-{3-[3-chloro-4-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-amide 
               
               
                  915 
                 365 
                 N-(4-{3-[3-Chloro-4-(2-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                  916 
                 445 
                 N-(4-{3-[3-Chloro-4-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                  917 
                 417 
                 Furan-2-carboxylic acid (4-{3-[3-chloro-4-(1-hydroxy-ethyl)-phenyl]-thioureido}-phenyl)-amide 
               
               
                  918 
                 371 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-amino-phenyl)-thioureido]-phenyl}-amide 
               
               
                  919 
                 501 
                 Furan-2-carboxylic acid {4-[3-(3-bromo-4-trifluoromethoxy-phenyl)-thioureido]-phenyl}-amide 
               
               
                  920 
                 423 
                 N-{4-[3-(3-tert-Butyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1025 
                 440 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-chloro-3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1026 
                 485 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-phenyl}-2-trifluoromethyl-benzamide 
               
               
                 1027 
                 412 
                 N-(4-Fluoro-phenyl)-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-benzamide 
               
               
                 1028 
                 446 
                 Isoquinoline-1-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1029 
                 468 
                 Isoquinoline-1-carboxylic acid {4-[3-(1-benzofuran-2-yl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 1030 
                 506 
                 Isoquinoline-1-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1031 
                 453 
                 Isoquinoline-1-carboxylic acid (4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1032 
                 435 
                 Benzofuran-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1033 
                 457 
                 Benzofuran-2-carboxylic acid {4-[3-(1-benzofuran-2-yl-ethyl)-thioureido]-phenyl)-amide 
               
               
                 1034 
                 495 
                 Benzofuran-2-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1035 
                 442 
                 Benzofuran-2-carboxylic acid (4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1036 
                 446 
                 Isoquinoline-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1037 
                 468 
                 Isoquinoline-3-carboxylic acid {4-[3-(1-benzofuran-2-yl-ethyl)-thioureido]-phenyl}-amide 
               
               
                 1038 
                 453 
                 Isoquinoline-3-carboxylic acid (4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1039 
                 506 
                 Isoquinoline-3-carboxylic acid (4-{3-[1-(4-bromo-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1040 
                 446 
                 Quinoline-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1041 
                 446 
                 Quinoline-4-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1042 
                 446 
                 Quinoline-6-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1043 
                 446 
                 Quinoline-8-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1044 
                 462 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-trifluoromethyl-benzamide 
               
               
                 1045 
                 419 
                 2-Cyano-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 1046 
                 473 
                 N-{4-[3-(3-Chloro-4-isobutoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1047 
                 414 
                 2-Fluoro-N-{4-[3-(3-fluoro-4-methoxy-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 1048 
                 475 
                 N-(4-{3-[3-Chloro-4-(2-methoxy-ethoxy)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1049 
                 398 
                 2-Fluoro-N-{4-[3-(3-fluoro-4-methyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 1050 
                 464 
                 2-Fluoro-N-{4-[3-(4-methoxy-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 1051 
                 449 
                 N-{4-[3-(2-Amino-5-trifluoromethyl-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1052 
                 459 
                 N-(4-{3-[1-(3-Chloro-4-methoxy-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1053 
                 417 
                 N-{4-[3-(5-Chloro-2-hydroxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1054 
                 435 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1055 
                 448 
                 2-Fluoro-N-{4-[3-(4-methyl-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-benzamide 
               
               
                 1056 
                 473 
                 (S)-N-(4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1057 
                 473 
                 N-(4-{3-[(1R)-1-(4-Bromo-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1058 
                 494 
                 2-Fluoro-N-(4-{3-[2-methoxy-4-(2,2,2-trifluoro-ethoxy)-phenyl]-thioureido}-phenyl)-benzamide 
               
               
                 1059 
                 399 
                 N-{4-[3-(2-Amino-5-fluoro-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1060 
                 502 
                 N-(4-{3-[1-(4-Dimethylsulfamoyl-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1061 
                 542 
                 2-Fluoro-N-[4-(3-{1-[4-(piperidine-1-sulfonyl)-phenyl]-ethyl}-thioureido)-phenyl]-benzamide 
               
               
                 1062 
                 562 
                 N-(4-{3-[2,4-Bis-(2,2,2-trifluoro-ethoxy)-phenyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1063 
                 409 
                 2-Fluoro-N-{4-[3-((1S)-1-p-tolyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1064 
                 409 
                 2-Fluoro-N-{4-[3-((1R)-1-p-tolyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1065 
                 394 
                 2-Fluoro-N-{4-[3-((1S)-1-phenyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1066 
                 429 
                 N-(4-{3-[(1R)-1-(4-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1067 
                 429 
                 N-(4-{3-[(1S)-1-(4-Chloro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1068 
                 394 
                 2-Fluoro-N-{4-[3-((1R)-1-phenyl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1069 
                 432 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-methoxy-benzamide 
               
               
                 1070 
                 447 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-phenyl}-2-methoxy-benzamide 
               
               
                 1071 
                 485 
                 N-(4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-phenyl)-2-methoxy-benzamide 
               
               
                 1072 
                 419 
                 3-Cyano-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 1073 
                 462 
                 N-(4-{3-[1-(4-Fluoro-phenyl)-ethyl]-thioureido}-phenyl)-4-trifluoromethyl-benzamide 
               
               
                 1074 
                 419 
                 4-Cyano-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-benzamide 
               
               
                 1075 
                 469 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2,3,5,6-tetramethyl-phenyl)-benzamide 
               
               
                 1076 
                 480 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-2,5-dimethoxy-phenyl)-2-fluoro-benzamide 
               
               
                 1077 
                 473 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2,5-dimethoxy-phenyl)-benzamide 
               
               
                 1078 
                 530 
                 N-{3,5-Dichloro-4-[3-(5-chloro-2,4-dimethoxy-phenyl)-thioureido]-phenyl}-2-fluoro-benzamide 
               
               
                 1079 
                 447 
                 N-(3-Chloro-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1080 
                 480 
                 2,3,4,5-Tetrafluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-3-methyl-phenyl)-benzamide 
               
               
                 1081 
                 462 
                 2,4,5-Trifluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-3-methyl-phenyl)-benzamide 
               
               
                 1082 
                 427 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-3-methyl-phenyl)-benzamide 
               
               
                 1083 
                 457 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methoxy-5-methyl-phenyl)-benzamide 
               
               
                 1084 
                 443 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-3-methoxy-phenyl)-benzamide 
               
               
                 1085 
                 570 
                 N-(2,6-Dibromo-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1086 
                 480 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-benzamide 
               
               
                 1087 
                 541 
                 N-(4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-2-fluoro-benzamide 
               
               
                 1088 
                 487 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-2-fluoro-benzamide 
               
               
                 1089 
                 503 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-2-trifluoromethyl-phenyl}-2-fluoro-benzamide 
               
               
                 1090 
                 447 
                 N-(2-Chloro-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1091 
                 454 
                 N-(2-Chloro-4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1092 
                 437 
                 N-(2-Cyano-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1093 
                 498 
                 N-(4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-cyano-phenyl)-2-fluoro-benzamide 
               
               
                 1094 
                 445 
                 N-(2-Cyano-4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1095 
                 460 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-2-cyano-phenyl}-2-fluoro-benzamide 
               
               
                 1096 
                 517 
                 N-(2-Benzoyl-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1097 
                 427 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-benzamide 
               
               
                 1098 
                 487 
                 N-(4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-2-fluoro-benzamide 
               
               
                 1099 
                 434 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-2-fluoro-benzamide 
               
               
                 1100 
                 449 
                 N-{4-[3-(1-Benzofuran-2-yl-ethyl)-thioureido]-2-methyl-phenyl}-2-fluoro-benzamide 
               
               
                 1101 
                 456 
                 N-(2-Dimethylamino-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1102 
                 526 
                 N-(2-Benzyloxy-4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1103 
                 519 
                 N-(2-Benzyloxy-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1104 
                 603 
                 N-[4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-(2-morpholin-4-yl-ethoxy)-phenyl]-2-fluoro-benzamide 
               
               
                 1105 
                 603 
                 N-[4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-(2-morpholin-4-yl-ethoxy)-phenyl]-2-fluoro-benzamide 
               
               
                 1106 
                 542 
                 2-Fluoro-N-[4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-(2-morpholin-4-yl-ethoxy)-phenyl]-benzamide 
               
               
                 1107 
                 485 
                 N-(2-Butoxy-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1108 
                 492 
                 N-(2-Butoxy-4-{3-[1-(4-cyano-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1109 
                 589 
                 N-[4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-(2-diethylamino-ethoxy)-phenyl]-2-fluoro-benzamide 
               
               
                 1110 
                 528 
                 N-(2-(2-Diethylamino-ethoxy)-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1111 
                 589 
                 N-[4-{3-[1-(4-Bromo-phenyl)-ethyl]-thioureido}-2-(2-diethylamino-ethoxy)-phenyl]-2-fluoro-benzamide 
               
               
                 1112 
                 457 
                 N-(2-Ethoxy-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-2-fluoro-benzamide 
               
               
                 1113 
                 464 
                 N-(4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-2-ethoxy-phenyl)-2-fluoro-benzamide 
               
               
                 1114 
                 468 
                 2-Fluoro-N-[4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-(2-nitrilo-ethoxy)-phenyl]-benzamide 
               
               
                 1115 
                 475 
                 N-[4-{3-[1-(4-Cyano-phenyl)-ethyl]-thioureido}-2-(2-nitrilo-ethoxy)-phenyl]-2-fluoro-benzamide 
               
               
                 1116 
                 443 
                 2-Fluoro-N-(4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methoxy-phenyl)-benzamide 
               
               
                 1117 
                 489 
                 2-Fluoro-N-(5-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-biphenyl-2-yl)-benzamide 
               
               
                 1118 
                 514 
                 Isoquinoline-1-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-amide 
               
               
                 1119 
                 503 
                 Benzofuran-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-amide 
               
               
                 1120 
                 514 
                 Isoquinoline-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-trifluoromethyl-phenyl)-amide 
               
               
                 1121 
                 471 
                 Isoquinoline-1-carboxylic acid (2-cyano-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1122 
                 460 
                 Benzofuran-2-carboxylic acid (2-cyano-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1123 
                 471 
                 Isoquinoline-3-carboxylic acid (2-cyano-4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1124 
                 460 
                 Isoquinoline-1-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-amide 
               
               
                 1125 
                 449 
                 Benzofuran-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-amide 
               
               
                 1126 
                 460 
                 Isoquinoline-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-2-methyl-phenyl)-amide 
               
               
                 1127 
                 396 
                 Pyrazine-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1128 
                 401 
                 Thiophene-2-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1129 
                 401 
                 Thiophene-3-carboxylic acid (4-{3-[1-(4-fluoro-phenyl)-ethyl]-thioureido}-phenyl)-amide 
               
               
                 1130 
                 500 
                 2-Isopropyl-thiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1131 
                 466 
                 2-Isopropyl-thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1132 
                 466 
                 2-Isopropyl-thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1133 
                 534 
                 2-Isopropyl-thiazole-4-carboxylic acid {4-[3-(3,5 bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1134 
                 480 
                 2-Butyl-thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1135 
                 514 
                 2-Butyl-thiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1136 
                 480 
                 2-Butyl-thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1137 
                 548 
                 2-Butyl-thiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1138 
                 438 
                 2-Methyl-thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1139 
                 438 
                 2-Methyl-thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1140 
                 505 
                 2-Methyl-thiazole-4-carboxylic acid {4-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1141 
                 534 
                 2-Phenyl-thiazole-4-carboxylic acid {4-[3-(4-chloro-3-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1142 
                 500 
                 2-Phenyl-thiazole-4-carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1143 
                 500 
                 2-Phenyl-thiazole-4-carboxylic acid {4-[3-(3,4-dichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1144 
                 568 
                 2-Phenyl-thiazole-4-carboxylic acid {4-[3-(3,5 bis-trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1145 
                 401 
                 2-Fluoro-N-{4-[3-(1-thiazol-2-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1146 
                 588 
                 2-Fluoro-N-[4-(3-{1-[1-(toluene-4-sulfonyl)-1H-indol-2-yl]-ethyl}-thioureido)-phenyl]-benzamide 
               
               
                 1147 
                 446 
                 2-Fluoro-N-{4-[3-(1-quinolin-2-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1148 
                 446 
                 2-Fluoro-N-{4-[3-(1-quinolin-4-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1149 
                 446 
                 2-Fluoro-N-{4-[3-(1-isoquinolin-3-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1150 
                 446 
                 2-Fluoro-N-{4-[3-(1-isoquinolin-1-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1151 
                 446 
                 2-Fluoro-N-{4-[3-(1-quinolin-6-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1152 
                 446 
                 2-Fluoro-N-{4-[3-(1-quinolin-3-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                 1153 
                 413 
                 2-Methoxy-N-{4-[3-(1-thiophen-3-yl-ethyl)-thioureido]-phenyl}-benzamide 
               
               
                   
               
             
          
         
       
     
     EXAMPLE 921 (METHOD 33) 
     [1,2,3]Thiadiazole-4carboxylic acid {4-[3-(3,5-dichloro-phenyl)-thioureido]-phenyl}-amide 
     To a solution of 3,5-dichloroaniline (0.16 g) in tetrahydrofuran (20 mL) is added freshly prepared 1,1′-thiocarbonyl-di-(1,2,4)-triazole (0.20 g) and the mixture is stirred for approximately 30 minutes at room temperature. [1,2,3]-Thiadiazole-4-carboxylic acid (4-amino-phenyl) amide (0.22 g) is added to the reaction flask and the mixture is stirred for approximately 6 hours. The solvent is then removed by evaporation under reduced pressure and warm acetonitrile (3 mL) is added. After 15 hours the mixture is filtered and the collected precipitate is washed with acetonitrile then diethyl ether, and air dried to provide the desired product as a white powder. [M+H] 424. 
     Using the above procedure and appropriate starting materials the following compounds were prepared: 
     
       
         
               
               
               
             
               
               
               
             
           
               
                   
               
               
                 EX. 
                   
                   
               
               
                 NO. 
                 M + H 
                 COMPOUND NAME 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 922 
                 465 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-3-fluoro-benzamide 
               
               
                 923 
                 477 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-methoxy-benzamide 
               
               
                 924 
                 465 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 925 
                 477 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -3-methoxy-benzamide 
               
               
                 926 
                 399 
                 N-{4-[3-(3,5-Dichloro-2-methoxy-4-methyl-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-acetamide 
               
               
                 927 
                 365 
                 N-{4-[3-(3-Chloro-4-methoxy-5-methyl-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-acetamide 
               
               
                 928 
                 331 
                 N-{4-[3-(2-Nitro-phenyl)-thioureido]-phenyl} -acetamide 
               
               
                 929 
                 331 
                 N-{4-[3-(4-Nitro-phenyl)-thioureido]-phenyl} -acetamide 
               
               
                 930 
                 477 
                 N-{4-[3-(3,5-Dichloro-4-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -4-methoxy-benzamide 
               
               
                 931 
                 351 
                 N-{4-[3-(2-Chloro-5-methoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 932 
                 428 
                 2-{4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-di- 
               
               
                   
                   
                 chloro-phenoxy}-acetamide 
               
               
                 933 
                 443 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-di- 
               
               
                   
                   
                 chloro-phenoxy}-acetic acid methyl ester 
               
               
                 934 
                 457 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-di- 
               
               
                   
                   
                 chloro-phenoxy} -acetic acid ethyl ester 
               
               
                 935 
                 447 
                 N-{4-[3-(3,5-Dichloro-4-phenoxy-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 936 
                 410 
                 N-(4-{3-[3,5-Dichloro-4-(2-nitrilo-ethoxy)-phenyl]- 
               
               
                   
                   
                 thioureido} -phenyl)-acetamide 
               
               
                 937 
                 485 
                 {4-[3-(4-Acetylamino-phenyl)-thioureido]-2,6-di- 
               
               
                   
                   
                 chloro-phenoxy} -acetic acid tert-butyl ester 
               
               
                 938 
                 469 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,5-dichloro- 
               
               
                   
                   
                 2-methoxy-4-methyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 939 
                 335 
                 N-{4-[3-(3-Chloro-4-methyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 940 
                 335 
                 N-{4-[3-(5-Chloro-2-methyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 941 
                 703 
                 N-{4-[3-(4-{4-[3-(4-Acetylamino-phenyl)-thioureido]- 
               
               
                   
                   
                 2-chloro-phenyldisulfanyl} -3-chloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-acetamide 
               
               
                 942 
                 369 
                 N-{4-[3-(3,5-Dichloro-4-methyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 943 
                 598 
                 N-{4-[3-(3,5-Diiodo-2,4-dimethoxy-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -acetamide 
               
               
                 944 
                 504 
                 N-{4-[3-(3,5-Dibromo-2,4-dimethoxy-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -acetamide 
               
               
                 945 
                 317 
                 N-{4-[3-(6-Methoxy-pyridin-3-yl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 946 
                 347 
                 N-{4-[3-(2,6-Dimethoxy-pyridin-3-yl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 947 
                 457 
                 Acetic acid 2-{4-[3-(4-acetylamino-phenyl)- 
               
               
                   
                   
                 thioureido]-2,6-dichloro-phenoxy} -ethyl ester 
               
               
                 948 
                 365 
                 4-[3-(4-Acetylamino-phenyl)-thioureido]-2-chloro- 
               
               
                   
                   
                 benzoic acid 
               
               
                 949 
                 346 
                 N-{4-[3-(3-Chloro-4-cyano-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-acetamide 
               
               
                 950 
                 512 
                 N-(4-{3-[5-Chloro-2-(4-chloro-phenoxy)-4- 
               
               
                   
                   
                 pyrrol-1-yl-phenyl]-thioureido}-phenyl)-acetamide 
               
               
                 951 
                 355 
                 N-{4-[3-(3,4-Dichloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 952 
                 339 
                 N-{4-[3-(3-Chloro-4-fluoro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 953 
                 447 
                 N-{4-[3-(3-Chloro-4-iodo-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 954 
                 400 
                 N-{4-[3-(4-Bromo-3-chloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 955 
                 424 
                 N-[4-(3-{4-[Bis-(2-hydroxy-ethyl)-amino]- 
               
               
                   
                   
                 3-chloro-phenyl}-thioureido)-phenyl]- 
               
               
                   
                   
                 acetamide 
               
               
                 956 
                 434 
                 N-(4-{3-[3-Chloro-4-(hexyl-methyl-amino)-phenyl]- 
               
               
                   
                   
                 thioureido}-phenyl)-acetamide 
               
               
                 957 
                 406 
                 N-(4-{3-[3-Chloro-4-(isobutyl-methyl-amino)-phenyl]- 
               
               
                   
                   
                 thioureido}-phenyl)-acetamide 
               
               
                 958 
                 389 
                 N-{4-[3-(3-Chloro-4-trifluoromethyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 959 
                 441 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-trifluoro- 
               
               
                   
                   
                 methyl-phenyl)-thioureido]-phenyl} -amide 
               
               
                 960 
                 459 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4- 
               
               
                   
                   
                 trifluoromethyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 961 
                 469 
                 N-{4-[3-(3-Chloro-4-trifluoromethyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -2-fluoro-benzamide 
               
               
                 962 
                 435 
                 N-{4-[3-(3,4-Dichloro-phenyl)-thioureido] -phenyl} -2- 
               
               
                   
                   
                 fluoro-benzamide 
               
               
                 963 
                 407 
                 Furan-2-carboxylic acid {4-[3-(3,4-dichloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 964 
                 425 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4-dichloro- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl}-amide 
               
               
                 965 
                 480 
                 N-{4-[3-(4-Bromo-3-chloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -2-fluoro-benzamide 
               
               
                 966 
                 527 
                 N-{4-[3-(3-Chloro-4-iodo-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -2-fluoro-benzamide 
               
               
                 967 
                 452 
                 Furan-2-carboxylic acid {4-[3-(4-bromo-3-chloro- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl} -amide 
               
               
                 968 
                 499 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-iodo- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl}-amide 
               
               
                 969 
                 391 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-4-fluoro- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl}-amide 
               
               
                 970 
                 470 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(4-bromo-3- 
               
               
                   
                   
                 chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 971 
                 517 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro-4- 
               
               
                   
                   
                 iodo-phenyl)-thioureido]-phenyl} -amide 
               
               
                 972 
                 419 
                 N-{4-[3-(3-Chloro-4-fluoro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -2-fluoro-benzamide 
               
               
                 973 
                 409 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3-chloro- 
               
               
                   
                   
                 4-fluoro-phenyl)-thioureido]-phenyl} -amide 
               
               
                 974 
                 388 
                 N-{4-[3-(3-Chloro-4-isoxazol-5-yl-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -acetamide 
               
               
                 975 
                 387 
                 N-(4-{3-[3-Chloro-4-(1H-pyrazol-3yl)-phenyl]- 
               
               
                   
                   
                 thioureido} -phenyl)-acetamide 
               
               
                 976 
                 355 
                 N-{4-[3-(2,3-Dichloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -acetamide 
               
               
                 977 
                 435 
                 N-{4-[3-(2,3-Dichloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -2-fluoro-benzamide 
               
               
                 978 
                 407 
                 Furan-2-carboxylic acid {4-[3-(2,3-dichloro- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl}-amide 
               
               
                 979 
                 425 
                 [1,2,3]Thiadiazole-4-carboxylic acid  
               
               
                   
                   
                 {4-[3-(2,3-dichloro-phenyl)-thioureido]-phenyl} -amide 
               
               
                 980 
                 355 
                 N-{4-[3-(2,5-Dichloro-phenyl)-thioureido]-phenyl} - 
               
               
                   
                   
                 acetamide 
               
               
                 981 
                 435 
                 N-{4-[3-(2,5-Dichloro-phenyl)-thioureodo]-phenyl} -2- 
               
               
                   
                   
                 fluoro-benzamide 
               
               
                 982 
                 407 
                 Furan-2-carboxylic acid {4-[3-(2,5-dichloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 983 
                 355 
                 N-{4-[3-(3,5-Dichloro-phenyl)-thioureido]-phenyl}- 
               
               
                   
                   
                 acetamide 
               
               
                 984 
                 435 
                 N-{4-[3-(3,5-Dichloro-phenyl)-thioureido]-phenyl}-2- 
               
               
                   
                   
                 fluoro-benzamide 
               
               
                 985 
                 407 
                 Furan-2-carboxylic acid {4-[3-(3,5-dichloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 986 
                 390 
                 N-{4-[3-(3,4,5-Trichloro-phenyl)-thioureido]-phenyl}- 
               
               
                   
                   
                 acetamide 
               
               
                 987 
                 470 
                 2-Fluoro-N-{4-[3-(3,4,5-trichloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-benzamide 
               
               
                 988 
                 442 
                 Furan-2-carboxylic acid {4-[3-(3,4,5-trichloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 989 
                 460 
                 [1,2,3]Thiadiazole-4-carboxylic acid {4-[3-(3,4,5- 
               
               
                   
                   
                 trichloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 990 
                 458 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 {4-[3-(3,4,5-chloro-4-isoxazol-5-yl-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 991 
                 457 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 (4-{3-[3-chloro-4-(1H-pyrazol-3-yl)-phenyl]- 
               
               
                   
                   
                 thioureido}-phenyl)-amide 
               
               
                 992 
                 391 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 {4-[3-(3-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 993 
                 373 
                 Furan-2-carboxylic acid {4-[3-(3-chloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 994 
                 401 
                 N-{4-[3-(3-Chloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 995 
                 373 
                 Furan-2-carboxylic acid {4-[3-(4-chloro- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl}-amide 
               
               
                 996 
                 401 
                 N-{4-[3-(4-Chloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 997 
                 391 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 {4-[3-(4-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 998 
                 401 
                 N-{4-[3-(2-Chloro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 999 
                 396 
                 3-(3-{4-[(Furan-2-carbonyl)-amino]- 
               
               
                   
                   
                 phenyl}-thioureido)-benzoic acid methyl ester 
               
               
                 1000 
                 424 
                 3-{3-[4-(2-Fluoro-benzoylamino)- 
               
               
                   
                   
                 phenyl]-thioureido}-benzoic acid methyl ester 
               
               
                 1001 
                 414 
                 3-(3-{4-[([1,2,3]Thiadiazole-4- 
               
               
                   
                   
                 carbonyl)-amino]-thioureido)-benzoic acid methyl ester 
               
               
                 1002 
                 409 
                 N-[4-[[[[3-(Aminocarbonyl)phenyl]- 
               
               
                   
                   
                 amino]thioxomethyl]amino]phenyl]-2-fluoro-benzamide 
               
               
                 1003 
                 373 
                 Furan-2-carboxylic acid {4-[3-(2-chloro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl}-amide 
               
               
                 1004 
                 381 
                 Furan-2-carboxylic acid {4-[3-(3-carbamoyl-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -amide 
               
               
                 1005 
                 399 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 {4-[3-(3-carbamoyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1006 
                 391 
                 [1,2,3]Thiadiazole-4-carboxylic acid 
               
               
                   
                   
                 {4-[3-(2-chloro-phenyl)-thioureido]-phenyl}-amide 
               
               
                 1007 
                 356 
                 Furan-2-carboxylic acid {4-[3-(3-fluoro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -amide 
               
               
                 1008 
                 383 
                 Furan-2-carboxylic acid {4-[3-(3-nitro-phenyl)- 
               
               
                   
                   
                 thioureido]-phenyl} -amide 
               
               
                 1009 
                 411 
                 2-Fluoro-N-{4-[3-(3-nitro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -benzamide 
               
               
                 1010 
                 422 
                 Furan-2-carboxylic acid {4-[3-(3-trifluoromethoxy- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl} -amide 
               
               
                 1011 
                 450 
                 2-Fluoro-N-{4-[3-(3-trifluoromethoxy- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl} -benzamide 
               
               
                 1012 
                 384 
                 2-Fluoro-N-{4-[3-(3-fluoro-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl} -benzamide 
               
               
                 1013 
                 410 
                 3-{3-[4-(2-Fluoro-benzoylamino)-phenyl]- 
               
               
                   
                   
                 thioureido} -benzoic acid 
               
               
                 1014 
                 382 
                 3-(3-{4-[(Furan-2-carbonyl)-amino]-phenyl} - 
               
               
                   
                   
                 thioureido)-benzoic acid 
               
               
                 1015 
                 408 
                 N-{4-[3-(3-Acetyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 1016 
                 502 
                 N-{4-[3-(3-Butylsulfamoyl-phenyl)-thioureido]- 
               
               
                   
                   
                 phenyl}-2-fluoro-benzamide 
               
               
                 1017 
                 380 
                 Furan-2-carboxylic acid {4-[3-(3-acetyl- 
               
               
                   
                   
                 phenyl)-thioureido]-phenyl} -amide 
               
               
                 1018 
                 447 
                 Furan-2-carboxylic acid (4-{3-[3-(2-hydroxy- 
               
               
                   
                   
                 ethanesulfonyl)-phenyl]-thioureido} -phenyl)-amide 
               
               
                 1019 
                 475 
                 2-Fluoro-N-(4-{3-[3-(2-hydroxy-ethanesulfonyl)- 
               
               
                   
                   
                 phenyl]-thioureido} -phenyl)-benzamide 
               
               
                 1020 
                 474 
                 Furan-2-carboxylic acid {4-[3-(3-butyl- 
               
               
                   
                   
                 sulfamoyl-phenyl)-thioureido]-phenyl}-amide 
               
               
                   
               
             
          
         
       
     
     EXAMPLE 1021 (METHOD 57) 
     1-(4-Fluoro-phenyl)-2-methyl-propan-1-ol 
     To solution of 4-fluorobenzaldehyde (2.0 g) in diethyl ether (40 mL) at 0° C. is added dropwise isopropylmagesium bromide (2.0 M, 9.6 mL) with stirring. After 1.5 hours the reaction is quenched with aqueous ammonium chloride and extracted with diethyl ether. The diethyl ether extracts are washed with saturated sodium chloride, dried over anhydrous magnesium sulfate, flitered and evaporated to give an oil. The oil is purifed by silica gel chromatography eluting with 10% dichloromethane-hexanes to give the product, a yellow oil (1.76 g). 
     EXAMPLE 1022 (METHOD 58) 
     1-(4Fluoro-phenyl)-2-methyl-propan-1-one 
     To a solution of 1-(4-Fluoro-phenyl)-2-methyl-propan-1-ol (1.6 g) in acetone (10 mL) at 0° C. is added Jones reagent (20 mL) with stirring. After 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol. Diethyl ether is added followed by anhydrous magnesium and the mixture is filtered and evaporated to give the product, a yellow oil (1.2 g). 
     EXAMPLE 1023 (METHOD 59) 
     3-Dimethylamino-5-trifluoromethyl-benzonitrile 
     To a solution of 3-dimethylamino-5-trifluoromethylbromobenzene (7.3 g) in N,N-dimethylformamide (20 mL) is added cuprous cyanide (2.7 g) and the reaction heated at reflux for 12 hours. The reaction is diluted with water (40 mL) and dichloromethane is added. The dichloromethane fraction is washed with concentrated ammonium hydroxide, then water. The solution is dried over anhydrous magnesium sulfate, filtered and concentrated to give a yellow solid which is recrystallized from hexanes to give a yellow solid, (4.7 g). 
     The foregoing compounds were tested for activity as herpes virus inhibitors. 
     Human Cytomegalovirus 
     Yield Assay 
     Monolayer cultures of human foreskin fibroblasts are infected with HCMV wild-type, typically at a multiplicity of infection equal to 0.2, in the presence of inhibitor compound (varying concentrations). At three days post-infection, total virus produced in these cultures (i.e. virus yield) is assessed by harvesting and titering the virus in 12-well plates of cultured human foreskin fibroblasts (done in the absence of inhibitor). Plaques are quantified at 2 weeks post-infection. An inhibitor of HCMV is identified by the reduction in titer of virus yield in the presence, compared to the titer in the absence of compound. In this assay, the relative anti-HCMV activity of an inhibitor is typically determined by calculating the IC 50  or IC 90  value, that is, the amount of compound required to reduce the virus yield by 50% or 90%, respectively. Table I describes IC 50  data for compounds tested against HCMV. 
     Microtiter Plate Assay 
     Ninety-six well plate cultures of human foreskin fibroblasts are infected in the presence of inhibitor compound with a HCMV recombinant mutant virus whose genome contains the prokaryotic beta-glucuronidase gene (Jefferson, R. A., S. M. Burgess, and D. Hirsh. 1986. Beta-glucuronidase from  Escherichia coli  as a gene fusion marker. Proc. Natl. Acad. Sci. USA 83:8447-8451) whose expression is controlled by a viral promoter. An example of such a virus is RV145 (Jones, T. R., V. P. Muzithras, and Y. Gluzman. 1991. Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. J. Virol. 65:5860-5872). Since it is under the control of a viral promoter, beta-glucuronidase expression is an indirect indicator of growth and replication of HCMV in this assay. At 96 hours post-infection, the infected cell lysates are prepared (using 50 mM sodium phosphate [pH7.0] containing 0.1% Triton X-100 and 0.1% sarkosyl) and assayed for beta-glucuronidase activity using a substrate for the enzyme which when cleaved yields either a product which can be measured colorimetrically in a spectrophotometer or fluorescently in a microfluorimeter. Examples of such substrates are p-nitrophenyl-beta-D-glucuronide and methylumbelliferylglucuronide, respectively. The presence of an antiviral compound is indicated by the reduced expression of the HCMV genome resident beta-glucuronidase gene, compared to the absence of inhibitor. Thus, the generation of the chromophore or fluorophore product in this assay is correspondingly reduced. Data from this assay generated using varying amounts of inhibitor compound is also used to estimate the IC 50  of an inhibitor compound. 
     HSV Antiviral (ELISA) assay 
     Vero cells (ATCC #CCL-81) are plated on 96-well tissue culture plates at 3.5×10 4  cells per 100 μl tissue culture DMEM (Dulbecco&#39;s modified Eagle media) supplemented with 2% fetal bovine serum (FBS) in each well. After overnight incubation @ 37° C. (in 5% CO 2 ) and 30 minutes prior to infection with HSV-1 (multiplicity of infection equal to 0.006), cells are either untreated, or treated with test compound (multiple concentrations) or reference standard drug control. After approximately 24 hours post-infection incubation @ 37° C. (in 5% CO 2 ), cells are fixed for ELISA assay. The primary antibody is murine anti-HSV glycoprotein D monoclonal primary antibody and the secondary antibody is goat anti-mouse IgG linked to β-galactosidase. Thus the extent of viral replication is determined by assessing β-galactosidase activity by quantifying the generation of the 4-methyl umbelliferone fluorescent cleavage product after addition of the methyl umbelliferyl-β-D-galactoside (Sigma #M1633) substrate on a microfluorimeter (365 nm for excitation and 450 nm for emission). Antiviral activity (IC 50 ) of the test compound is determined by comparing the flourescence obtained in absence of compound to that obtained in the presence of compound. Data is shown in Table I. 
     VZV Antiviral (ELISA) assay 
     For the generation of stock VZV to be used in the assay, VZV strain Ellen (ATCC #VR-1367) is used to infect human foreskin fibroblast (HFF) cells at low multiplicity (less than 0.1) and incubated overnight at 37° C. in 5% CO 2 . After the overnight incubation, the mixture of uninfected and VZV-infected HFF infected cells are then harvested and added to each well of 96-well plates (3.5×10 4  cells in 100 μl DMEM supplemented with 2% FBS) which contain test compound or the reference standard drug control (in 100 μl DMEM supplemented with 2% FBS per well). These cells are incubated for three days at 37° C. in 5% CO 2 , then fixed for ELISA assay. The primary antibody is murine anti-VZV glycoprotein II monoclonal antibody (Applied Biosystems, Inc. #13-145-100) and the secondary antibody is goat anti-mouse IgG linked to β-galactosidase. Thus the extent of viral replication is determined by assessing β-galactosidase activity by quantifying the generation of the 4-methyl umbelliferone fluorescent cleavage product after addition of the methyl umbelliferyl-β-D-galactoside (Sigma #M1633) substrate on a microfluorimeter (365 nm for excitation and 450 nm for emission). Antiviral activity (IC 50 ) of the test compound is determined by comparing the flourescence obtained in absence of compound to that obtained in the presence of compound. Data is shown in Table I. 
     
       
         
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE I 
               
               
                   
               
               
                   
                   
                 % inhibition 
                 IC50 
                   
               
               
                   
                 IC50 (ug/ml) 
                 10 ug/ml 
                 (ug/ml) 
                 IC50 (ug/ml) 
               
               
                 Example 
                 HSV 
                 VZV 
                 VZV 
                 HCMV 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 86 
                 &gt;10 
                 32 
                 &gt;10 
                 0.04 
               
               
                 88 
                 &gt;10 
                   
                 .03 
                 0.013 
               
               
                 90 
                 &gt;10 
                   
                   
                 0.07 
               
               
                 91 
                 &gt;10 
                 6 
                 &gt;10 
                 0.018 
               
               
                 144 
                 7 
                   
                   
                 10 
               
               
                 145 
                 2 
                 51 
                 &gt;15 
                 &gt;10 
               
               
                 146 
                 &gt;10 
                 14 
                 &gt;10 
                 &gt;10 
               
               
                 147 
                 10 
                 42 
                 &gt;10 
                 &gt;50 
               
               
                 153 
                 2 
                 8 
                 &gt;10 
                 &gt;10 
               
               
                 154 
                 4 
                 23 
                 &gt;10 
                 10 
               
               
                 155 
                 5 
                 22 
                 &gt;10 
                 5 
               
               
                 158 
                 4 
                 52 
                 &gt;15 
                 &gt;10 
               
               
                 159 
                 &gt;10 
                 62 
                 &gt;10 
                 &gt;10 
               
               
                 160 
                 2.5 
                 27 
                 &gt;10 
                 &gt;10 
               
               
                 161 
                 3 
                 113 
                 5 
                 &gt;10 
               
               
                 163 
                 3 
                 30 
                 &gt;10 
                 7 
               
               
                 166 
                 9 
                 30 
                 &gt;10 
                 &gt;10 
               
               
                 167 
                 10 
                 70 
                 3.8 
                 9 
               
               
                 168 
                 3 
                   
                 &gt;10 
                 2.5 
               
               
                 169 
                 3 
                 26 
                 &gt;10 
                 4 
               
               
                 170 
                 &gt;10 
                 32 
                 &gt;10 
                 0.2 
               
               
                 172 
                 &gt;10 
                 25 
                 &gt;10 
                 &gt;10 
               
               
                 173 
                 &gt;10 
                 31 
                 &gt;10 
                 0.08 
               
               
                 174 
                 50 
                 8 
                 &gt;10 
                 6 
               
               
                 175 
                 2 
                 24 
                 &gt;10 
                 &gt;10 
               
               
                 200 
                 &gt;10 
                 55 
                 &gt;15 
                 0.02 
               
               
                 201 
                 &gt;10 
                 78 
                 8 
                 0.023 
               
               
                 224 
                 3.5 
                 30 
                 &gt;10 
                 0.8 
               
               
                 225 
                 1 
                 30 
                 &gt;10 
                 &gt;10 
               
               
                 230 
                 &gt;10 
                   
                 &gt;10 
                 0.015 
               
               
                 233 
                 &gt;10 
                 30 
                 &gt;10 
                 0.09 
               
               
                 236 
                 &gt;10 
                 40 
                 &gt;10 
                 0.7 
               
               
                 237 
                 &gt;10 
                 17 
                 &gt;10 
                 0.02 
               
               
                 246 
                 &gt;10 
                 37 
                 4 
                 0.05 
               
               
                 249 
                 &gt;10 
                 59 
                 &gt;10 
                 0.4 
               
               
                 264 
                 &gt;10 
                 28 
                 &gt;10 
                 &gt;10 
               
               
                 279 
                 &gt;10 
                   
                 &gt;10 
                 &gt;10 
               
               
                 280 
                 &gt;10 
                   
                 &gt;10 
                 &gt;10 
               
               
                 281 
                 &gt;10 
                 31 
                 &gt;10 
                 &gt;10 
               
               
                 288 
                 &gt;10 
                 30 
                 &gt;10 
                 4 
               
               
                 323 
                 3 
                 45 
                 &gt;10 
                 0.03 
               
               
                 330 
                 &gt;10 
                 29 
                 &gt;10 
                 0.15 
               
               
                 331 
                 1.8 
                 98 
                 5 
                 2 
               
               
                 341 
                 2 
                 50 
                 &gt;10 
                 0.15 
               
               
                 344 
                 4 
                 72 
                 7 
                 0.25 
               
               
                 350 
                 &gt;10 
                 50 
                 &gt;10 
                 1 
               
               
                 351 
                 3 
                 90 
                 3.5 
                 0.3 
               
               
                 352 
                 3 
                 51 
                 &gt;10 
                 0.6 
               
               
                 353 
                 0.6 
                 86 
                 7 
                 0.04 
               
               
                 354 
                 0.8 
                 75 
                 7 
                 2 
               
               
                 361 
                 8 
                 26 
                 &gt;10 
                 0.25 
               
               
                 365 
                 10 
                 75 
                 5 
                 0.035 
               
               
                 368 
                 &gt;10 
                 20 
                 &gt;10 
                 0.35 
               
               
                 371 
                 &gt;10 
                 45 
                 &gt;10 
                 &gt;10 
               
               
                 376 
                 3 
                 83 
                 7 
                 0.8 
               
               
                 378 
                 &gt;10 
                 31 
                 &gt;10 
                 0.033 
               
               
                 379 
                 &gt;10 
                 27 
                 &gt;10 
                 &gt;10 
               
               
                 391 
                 8 
                 97 
                 6 
                 0.019 
               
               
                 396 
                 &gt;10 
                 26 
                 &gt;10 
                 0.7 
               
               
                 398 
                 &gt;10 
                 5 
                 &gt;10 
                 0.13 
               
               
                 403 
                 6 
                 108 
                 &gt;15 
                 0.09 
               
               
                 406 
                 &gt;10 
                 28 
                 &gt;10 
                 0.12 
               
               
                 409 
                 &gt;10 
                 5 
                 &gt;10 
                 2 
               
               
                 411 
                 8 
                 99 
                 2 
                 0.024 
               
               
                 413 
                 5 
                 103 
                 5 
                 0.081 
               
               
                 416 
                 &gt;10 
                 87 
                 &gt;15 
                 0.25 
               
               
                 421 
                 8 
                   
                 &gt;10 
                 0.75 
               
               
                 422 
                 5 
                 69 
                 &gt;10 
                 0.058 
               
               
                 424 
                 3 
                 103 
                 0.7 
                 0.09 
               
               
                 430 
                 &gt;10 
                   
                 &gt;10 
                 0.4 
               
               
                 431 
                 &gt;10 
                   
                 &gt;10 
                 0.06 
               
               
                 435 
                 10 
                 94 
                 0.9 
                 0.08 
               
               
                 436 
                 10 
                   
                 &gt;10 
                 0.15 
               
               
                 438 
                 5 
                 73 
                 1.5 
                 3 
               
               
                 439 
                 9 
                 46 
                 &gt;10 
                 0.5 
               
               
                 440 
                 1 
                   
                 9 
                 0.3 
               
               
                 441 
                 &gt;10 
                   
                 &gt;10 
                 0.17 
               
               
                 445 
                 10 
                   
                 &gt;10 
                 0.15 
               
               
                 446 
                 10 
                   
                 &gt;10 
                 0.7 
               
               
                 447 
                 &gt;10 
                   
                 &gt;10 
                 &gt;10 
               
               
                 449 
                 &gt;10 
                   
                 &gt;10 
                 1.6 
               
               
                 450 
                 &gt;10 
                   
                 &gt;10 
                 0.05 
               
               
                 451 
                 8 
                   
                 &gt;10 
                 0.15 
               
               
                 453 
                 &gt;10 
                   
                 3 
                 0.07 
               
               
                 455 
                 &gt;10 
                 30 
                 &gt;10 
                 0.3 
               
               
                 456 
                 &gt;10 
                 12 
                 &gt;10 
                 0.07 
               
               
                 457 
                 &gt;10 
                 26 
                 &gt;10 
                 0.019 
               
               
                 462 
                 &gt;10 
                 6 
                 &gt;10 
                 1 
               
               
                 464 
                 &gt;10 
                 25 
                 &gt;10 
                 0.15 
               
               
                 466 
                 &gt;10 
                 93 
                 &gt;10 
                 0.011 
               
               
                 467 
                 &gt;10 
                 93 
                 &gt;15 
                 0.12 
               
               
                 468 
                 &gt;10 
                 50 
                 &gt;10 
                 0.06 
               
               
                 469 
                 &gt;10 
                 54 
                 &gt;10 
                 0.1 
               
               
                 470 
                 0.6 
                 17 
                 &gt;10 
                 0.7 
               
               
                 472 
                 &gt;10 
                 31 
                 &gt;10 
                 0.8 
               
               
                 473 
                 &gt;10 
                 40 
                 &gt;10 
                 0.3 
               
               
                 474 
                 &gt;10 
                 22 
                 &gt;10 
                 1 
               
               
                 478 
                 &gt;10 
                 31 
                 &gt;10 
                 0.4 
               
               
                 479 
                 &gt;10 
                 30 
                 &gt;10 
                 0.1 
               
               
                 481 
                 &gt;10 
                 32 
                 &gt;10 
                 0.5 
               
               
                 482 
                 9 
                 33 
                 &gt;10 
                 0.3 
               
               
                 485 
                 &gt;10 
                 11 
                 &gt;10 
                 0.03 
               
               
                 486 
                 &gt;10 
                 22 
                 &gt;10 
                 0.045 
               
               
                 488 
                 &gt;10 
                 13 
                 &gt;10 
                 1.2 
               
               
                 489 
                 5 
                 99 
                 3.5 
                 0.17 
               
               
                 494 
                 &gt;10 
                 6 
                 &gt;10 
                 3.5 
               
               
                 495 
                 &gt;10 
                 27 
                 &gt;10 
                 3 
               
               
                 500 
                 &gt;10 
                 48 
                 &gt;10 
                 0.021 
               
               
                 501 
                 &gt;10 
                 10 
                 &gt;10 
                 0.032 
               
               
                 503 
                 8 
                 64 
                 &gt;10 
                 0.053 
               
               
                 505 
                 10 
                 79 
                 8 
                 0.2 
               
               
                 508 
                 &gt;10 
                 7 
                 &gt;10 
                 0.013 
               
               
                 509 
                 &gt;10 
                 31 
                 &gt;10 
                 0.03 
               
               
                 510 
                 8 
                 19 
                 &gt;10 
                 0.04 
               
               
                 513 
                 &gt;10 
                 10 
                 &gt;10 
                 0.011 
               
               
                 516 
                 &gt;10 
                 7 
                 &gt;10 
                 0.04 
               
               
                 521 
                 10 
                 97 
                 3 
                 0.04 
               
               
                 522 
                 &gt;10 
                 32 
                 &gt;10 
                 0.025 
               
               
                 524 
                 4 
                 95 
                 2 
                 0.055 
               
               
                 526 
                 &gt;10 
                 22 
                 2.5 
                 3 
               
               
                 528 
                 3.2 
                 107 
                 5 
                 0.25 
               
               
                 530 
                 5 
                 96 
                 6 
                 0.15 
               
               
                 532 
                 &gt;10 
                   
                 6 
                 0.009 
               
               
                 534 
                 7 
                   
                 &gt;10 
                 0.05 
               
               
                 535 
                 &gt;10 
                   
                 &gt;10 
                 0.016 
               
               
                 537 
                 9 
                   
                 10 
                 0.003 
               
               
                 539 
                 &gt;10 
                   
                 &gt;10 
                 0.036 
               
               
                 541 
                 7 
                   
                 &gt;10 
                 0.017 
               
               
                 542 
                 &gt;10 
                   
                 &gt;10 
                 0.0011 
               
               
                 544 
                 &gt;10 
                   
                 &gt;10 
                 0.02 
               
               
                 545 
                 3 
                   
                 7 
                 0.012 
               
               
                 546 
                 1.7 
                   
                 7 
                 0007 
               
               
                 547 
                 &gt;10 
                   
                 10 
                 0.006 
               
               
                 548 
                 &gt;10 
                   
                 &gt;lo 
                 0.008 
               
               
                 550 
                 &gt;10 
                   
                 &gt;10 
                 0.013 
               
               
                 551 
                 &gt;10 
                   
                 &gt;10 
                 0.043 
               
               
                 554 
                 &gt;10 
                   
                 1.5 
                 0.01 
               
               
                 555 
                 &gt;10 
                   
                 4 
                 0.008 
               
               
                 556 
                 &gt;10 
                   
                 &gt;7.5 
                 0.006 
               
               
                 557 
                 &gt;10 
                   
                 &gt;10 
                 0.006 
               
               
                 558 
                 7 
                   
                 &gt;10 
                 0.05 
               
               
                 559 
                 &gt;10 
                   
                 &gt;10 
                 0.012 
               
               
                 560 
                 &gt;10 
                   
                 &gt;10 
                 0.008 
               
               
                 561 
                 &gt;10 
                   
                 8 
                 0.05 
               
               
                 562 
                 &gt;10 
                   
                 8 
                 0.004 
               
               
                 564 
                 &gt;10 
                   
                 5 
                 0.027 
               
               
                 565 
                 &gt;10 
                   
                 0.22 
                 0.01 
               
               
                 571 
                   
                   
                 &gt;10 
                 0.013 
               
               
                 572 
                   
                   
                 &gt;10 
                 0.0078 
               
               
                 573 
                   
                   
                 &gt;10 
                 0.05 
               
               
                 574 
                   
                   
                 &gt;10 
                 0.089 
               
               
                 575 
                   
                   
                 2 
                 0.017 
               
               
                 579 
                   
                   
                 6 
                 0.05 
               
               
                 581 
                   
                   
                 &gt;10 
                 0.01 
               
               
                 582 
                   
                   
                 8 
                 0.01 
               
               
                 584 
                   
                   
                 &gt;10 
                 0.0026 
               
               
                 585 
                   
                   
                 &gt;10 
                 0.015 
               
               
                 587 
                   
                   
                 &gt;10 
                 0.005 
               
               
                 588 
                 &gt;10 
                   
                 0.36 
                 0.03 
               
               
                 590 
                 &gt;10 
                   
                 1 
                 0.12 
               
               
                 592 
                 &gt;10 
                   
                 2 
                 0.049 
               
               
                 594 
                 &gt;10 
                   
                 &gt;10 
                 0.011 
               
               
                 595 
                 &gt;10 
                   
                 3 
                 0.022 
               
               
                 597 
                 &gt;10 
                   
                 &gt;10 
                 0.008 
               
               
                 599 
                 &gt;10 
                   
                 &gt;10 
                 0.005 
               
               
                 600 
                 &gt;10 
                   
                 &gt;10 
                 0.012 
               
               
                 601 
                 &gt;10 
                   
                 &gt;10 
                 0.0011 
               
               
                 602 
                 &gt;10 
                   
                 &gt;10 
                 0.0015 
               
               
                 603 
                 &gt;10 
                   
                 &gt;10 
                 &gt;0.5 
               
               
                 604 
                 &gt;10 
                   
                 10 
                 0.025 
               
               
                 605 
                 &gt;10 
                   
                 10 
                 0.062 
               
               
                 606 
                 &gt;10 
                   
                 &gt;10 
                 0.0023 
               
               
                 607 
                 8 
                   
                 &gt;10 
                 0.09 
               
               
                 611 
                   
                   
                 &gt;10 
                 0.5 
               
               
                 612 
                   
                   
                 1 
                 0.049 
               
               
                 613 
                   
                   
                 &gt;10 
                 0.011 
               
               
                 614 
                   
                   
                 7 
                 0.024 
               
               
                 615 
                   
                   
                 &gt;10 
                 0.005 
               
               
                 617 
                   
                   
                 &gt;10 
                 0.013 
               
               
                 618 
                   
                   
                 &gt;10 
                 0.0016 
               
               
                 624 
                   
                   
                 &gt;10 
                 0.002 
               
               
                 626 
                 10 
                   
                 &gt;10 
                 0.07 
               
               
                 627 
                 10 
                   
                 &gt;10 
                 0.014 
               
               
                 630 
                 &gt;10 
                   
                 4 
                 0.4 
               
               
                 631 
                 6 
                   
                 6 
                 0.15 
               
               
                 635 
                 &gt;10 
                   
                 4 
                 0.15 
               
               
                 637 
                 &gt;10 
                   
                 &gt;10 
                 0.014 
               
               
                 638 
                 &gt;10 
                   
                 &gt;10 
                 0.01 
               
               
                 639 
                 &gt;10 
                   
                 &gt;10 
                 0.07 
               
               
                 644 
                 &gt;10 
                   
                 8 
                 0.03 
               
               
                 645 
                 &gt;10 
                   
                 10 
                 0.003 
               
               
                 646 
                 &gt;10 
                   
                 2.5 
                 0.03 
               
               
                 647 
                 &gt;10 
                   
                 0.1 
                 0.007 
               
               
                 648 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 650 
                 &gt;10 
                   
                   
                 0.05 
               
               
                 651 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 652 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 654 
                 &gt;10 
                   
                   
                 0.07 
               
               
                 655 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 657 
                 6 
                   
                   
                 0.04 
               
               
                 662 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 663 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 665 
                 5 
                   
                   
                 0.02 
               
               
                 667 
                 8 
                   
                   
                 0.03 
               
               
                 668 
                 &gt;10 
                   
                   
                 0.009 
               
               
                 670 
                 &gt;10 
                   
                   
                 0.02 
               
               
                 671 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 674 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 675 
                 &gt;10 
                   
                   
                 0.05 
               
               
                 676 
                 &gt;10 
                   
                   
                 0.013 
               
               
                 678 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 679 
                 10 
                   
                   
                 0.01 
               
               
                 681 
                 &gt;10 
                   
                   
                 0.02 
               
               
                 682 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 683 
                 10 
                   
                   
                 0.02 
               
               
                 684 
                 10 
                   
                   
                 0.005 
               
               
                 685 
                 10 
                   
                   
                 0.006 
               
               
                 686 
                 &gt;10 
                   
                   
                 0.007 
               
               
                 688 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 689 
                 7 
                   
                   
                 0.007 
               
               
                 690 
                 7 
                   
                   
                 0.004 
               
               
                 691 
                 &gt;10 
                   
                   
                 0.008 
               
               
                 692 
                 6 
                   
                   
                 0.04 
               
               
                 693 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 694 
                 10 
                   
                   
                 0.04 
               
               
                 697 
                 7 
                   
                   
                 0.04 
               
               
                 698 
                 6 
                   
                   
                 0.04 
               
               
                 699 
                 &gt;10 
                   
                   
                 0.016 
               
               
                 700 
                 &gt;10 
                   
                   
                 0.004 
               
               
                 701 
                 &gt;10 
                   
                   
                 0.008 
               
               
                 702 
                 4 
                   
                   
                 0.01 
               
               
                 703 
                 &gt;10 
                   
                   
                 0.007 
               
               
                 704 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 705 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 706 
                 &gt;10 
                   
                   
                 0.04 
               
               
                 707 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 708 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 709 
                 &gt;10 
                   
                   
                 0.05 
               
               
                 710 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 711 
                 &gt;10 
                   
                   
                 0.004 
               
               
                 713 
                 &gt;10 
                   
                   
                 0.009 
               
               
                 714 
                 &gt;10 
                   
                   
                 0.02 
               
               
                 715 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 716 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 717 
                 &gt;10 
                   
                   
                 0.003 
               
               
                 718 
                 6 
                   
                   
                 0.02 
               
               
                 720 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 722 
                 &gt;10 
                   
                   
                 0.015 
               
               
                 723 
                 &gt;10 
                   
                   
                 0.03 
               
               
                 726 
                 &gt;10 
                   
                   
                   
               
               
                 728 
                 9 
                   
                   
                   
               
               
                 729 
                   
                   
                   
                 0.02 
               
               
                 730 
                   
                   
                   
                 0.033 
               
               
                 731 
                 &gt;10 
                   
                   
                 0.007 
               
               
                 732 
                   
                   
                   
                 0.022 
               
               
                 733 
                   
                   
                   
                 0.018 
               
               
                 734 
                 &gt;10 
                   
                   
                 0.009 
               
               
                 735 
                   
                   
                   
                 0.022 
               
               
                 736 
                   
                   
                   
                 0.012 
               
               
                 737 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 738 
                 &gt;10 
                   
                   
                 0.11 
               
               
                 739 
                 &gt;10 
                   
                   
                 0.02 
               
               
                 740 
                   
                   
                   
                 0.1 
               
               
                 741 
                 &gt;10 
                   
                   
                 0.02 
               
               
                 742 
                 &gt;10 
                   
                   
                 0.009 
               
               
                 743 
                 &gt;10 
                   
                   
                 0.09 
               
               
                 745 
                 9 
                   
                   
                 0.0025 
               
               
                 746 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 747 
                 &gt;10 
                   
                   
                 0.002 
               
               
                 748 
                 &gt;10 
                   
                   
                 0.28 
               
               
                 749 
                 &gt;10 
                   
                   
                 0.06 
               
               
                 750 
                 &gt;10 
                   
                   
                 0.01 
               
               
                 759 
                 &gt;10 
                   
                 2 
                 &gt;10 
               
               
                 762 
                 &gt;10 
                   
                 1.5 
                 0.002 
               
               
                 763 
                 5 
                   
                 5 
                 0.004 
               
               
                 764 
                 &gt;10 
                   
                   
                 0.004 
               
               
                 766 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 767 
                 &gt;10 
                   
                 1 
                 0.006 
               
               
                 768 
                 &gt;10 
                   
                   
                 0.005 
               
               
                 769 
                 &gt;10 
                   
                   
                 0.04 
               
               
                 770 
                 &gt;10 
                   
                   
                 0.006 
               
               
                 796 
                 &gt;10 
                   
                 &gt;7.5 
                 4 
               
               
                 815 
                   
                   
                 0.27 
                 0.0095 
               
               
                 816 
                   
                   
                 &gt;7.5 
                 0.0053 
               
               
                 818 
                   
                   
                 &gt;7.5 
                 0.0016 
               
               
                 820 
                   
                   
                 &gt;7.5 
                 0.006 
               
               
                 821 
                   
                   
                 &gt;7.5 
                 0.005 
               
               
                 822 
                   
                   
                 &gt;7.5 
                 0.018 
               
               
                 824 
                   
                   
                 0.17 
                 0.014 
               
               
                 825 
                   
                   
                 &gt;7.5 
                 0.0013 
               
               
                 828 
                   
                   
                 &gt;7.5 
                 0.002 
               
               
                 829 
                   
                   
                 &gt;7.5 
                 0.002 
               
               
                 830 
                   
                   
                 &gt;7.5 
                 0.0003 
               
               
                 831 
                   
                   
                 &gt;7.5 
                 0.0011 
               
               
                 832 
                   
                   
                 &gt;7.5 
                 0.001 
               
               
                 833 
                   
                   
                 &gt;7.5 
                 0.0019 
               
               
                 834 
                   
                   
                 &gt;7.5 
                 0.002 
               
               
                 835 
                   
                   
                 &gt;7.5 
                 0.005 
               
               
                 836 
                   
                   
                 &gt;7.5 
                 0.004 
               
               
                 837 
                   
                   
                 3.60 
                 0.03 
               
               
                 838 
                   
                   
                 &gt;7.5 
                 0.0007 
               
               
                 839 
                   
                   
                 &gt;7.5 
                 0.004 
               
               
                 840 
                   
                   
                 0.14 
                 0.0015 
               
               
                 841 
                   
                   
                 0.77 
                 0.0011 
               
               
                 842 
                   
                   
                 1.55 
                 0.02 
               
               
                 843 
                   
                   
                 &gt;7.5 
                 0.0031 
               
               
                 844 
                   
                   
                 1.03 
                 0.0008 
               
               
                 845 
                   
                   
                 &gt;7.5 
                 0.0060 
               
               
                 846 
                   
                   
                 1.04 
                 0.0130 
               
               
                 847 
                   
                   
                 &gt;7.5 
                 0.0008 
               
               
                 848 
                   
                   
                 0.19 
                 0.002 
               
               
                 849 
                   
                   
                 1.82 
                 0.002 
               
               
                 850 
                   
                   
                 2.33 
                 0.0008 
               
               
                 851 
                   
                   
                 1.43 
                 0.017 
               
               
                 852 
                   
                   
                 &gt;7.5 
                 0.005 
               
               
                 853 
                   
                   
                 0.62 
                 0.004 
               
               
                 854 
                   
                   
                   
                 0.02 
               
               
                 855 
                   
                   
                   
                 0.02 
               
               
                 856 
                   
                   
                   
                 0.02 
               
               
                 857 
                   
                   
                 &gt;7.5 
                 0.0006 
               
               
                 858 
                   
                   
                 &gt;7.5 
                 0.0007 
               
               
                 859 
                   
                   
                 0.5 
                 0.00001 
               
               
                 860 
                   
                   
                 &gt;7.5 
                 0.001 
               
               
                 861 
                   
                   
                 &gt;7.5 
                 0.002 
               
               
                 862 
                   
                   
                 &gt;7.5 
                 0.1 
               
               
                 863 
                   
                   
                 &gt;7.5 
                 2.0 
               
               
                 864 
                   
                   
                 &gt;7.5 
                 0.5 
               
               
                 865 
                   
                   
                 &gt;7.5 
                 0.0001 
               
               
                 866 
                 &gt;10 
                 50 
                 &gt;10 
                 0.035 
               
               
                 875 
                 &gt;50 
                 18 
                 &gt;10 
                 &gt;2.2 
               
               
                 879 
                 4 
                 65 
                 10 
                 0.3 
               
               
                 888 
                 6 
                 31 
                 &gt;10 
                 0.06 
               
               
                 897 
                 &gt;10 
                 62 
                 &gt;10 
                 0.037 
               
               
                 902 
                 &gt;10 
                 10 
                 &gt;10 
                 0.12 
               
               
                 904 
                 12 
                 58 
                 &gt;10 
                 0.4 
               
               
                 905 
                 4 
                 82 
                 2 
                 0.3 
               
               
                 907 
                 &gt;10 
                 36 
                 &gt;10 
                 0.009 
               
               
                 911 
                 &gt;10 
                 25 
                 &gt;10 
                 0.3 
               
               
                 912 
                 &gt;10 
                 0 
                 &gt;10 
                 0.16 
               
               
                 913 
                 &gt;10 
                 15 
                 &gt;10 
                 0.056 
               
               
                 917 
                 10 
                   
                 &gt;10 
                 0.2 
               
               
                 918 
                 &gt;10 
                   
                 &gt;10 
                 0.03 
               
               
                 919 
                 &gt;10 
                   
                 &gt;10 
                 0.05 
               
               
                 921 
                 8 
                 85 
                 7 
                 0.05 
               
               
                 922 
                 &gt;10 
                 84 
                 7 
                 0.01 
               
               
                 939 
                 &gt;10 
                 53 
                 15 
                 0.018 
               
               
                 960 
                 &gt;10 
                 58 
                 &gt;10 
                 0.03 
               
               
                 961 
                 &gt;10 
                 20 
                 &gt;10 
                 0.006 
               
               
                 964 
                 &gt;10 
                 9 
                 &gt;10 
                 0.03 
               
               
                 965 
                 &gt;10 
                 36 
                 &gt;10 
                 0.008 
               
               
                 966 
                 &gt;10 
                 42 
                 &gt;10 
                 0.02 
               
               
                 969 
                 &gt;10 
                 40 
                 &gt;10 
                 0.03 
               
               
                 970 
                 &gt;10 
                 16 
                 &gt;10 
                 0.06 
               
               
                 971 
                 &gt;10 
                 9 
                 &gt;10 
                 0.013 
               
               
                 972 
                 &gt;10 
                 95 
                 &gt;15 
                 0.006 
               
               
                 974 
                 &gt;10 
                 14 
                 &gt;10 
                 0.011 
               
               
                 979 
                 8 
                 88 
                 12 
                 0.19 
               
               
                 980 
                 &gt;10 
                 56 
                 &gt;10 
                 0.05 
               
               
                 983 
                 &gt;10 
                 52 
                 &gt;10 
                 0.12 
               
               
                 986 
                 &gt;10 
                 5 
                 &gt;10 
                 0.031 
               
               
                 989 
                 &gt;10 
                 21 
                 &gt;10 
                 0.016 
               
               
                 990 
                 8 
                 99 
                 4.5 
                 0.011 
               
               
                 991 
                 &gt;10 
                 3 
                 &gt;10 
                 0.022 
               
               
                 992 
                 &gt;10 
                 29 
                 &gt;10 
                 0.018 
               
               
                 993 
                 &gt;10 
                   
                 &gt;10 
                 0.013 
               
               
                 994 
                 &gt;10 
                   
                 &gt;10 
                 0.07 
               
               
                 996 
                 10 
                   
                 &gt;10 
                 0.15 
               
               
                 998 
                 &gt;10 
                   
                 &gt;10 
                 0.016 
               
               
                 1000 
                 &gt;10 
                   
                 &gt;10 
                 0.39 
               
               
                 1002 
                 &gt;10 
                   
                 &gt;10 
                 0.07 
               
               
                 1004 
                 &gt;10 
                 36 
                 &gt;10 
                 0.5 
               
               
                 1005 
                 &gt;10 
                 16 
                 &gt;10 
                 2 
               
               
                 1006 
                 &gt;10 
                 13 
                 &gt;10 
                 0.2 
               
               
                 1007 
                 &gt;10 
                 18 
                 &gt;10 
                 0.11 
               
               
                 1008 
                 &gt;10 
                 15 
                 &gt;10 
                 0.12 
               
               
                 1009 
                 10 
                 22 
                 &gt;10 
                 0.2 
               
               
                 1011 
                 &gt;10 
                 20 
                 &gt;10 
                 0.039 
               
               
                 1018 
                 &gt;10 
                 2 
                 &gt;10 
                 0.4 
               
               
                 1019 
                 &gt;10 
                 2 
                 &gt;10 
                 1.5 
               
               
                 1021 
                 8 
                 68 
                 &gt;10 
                 0.094 
               
               
                 1126 
                 &gt;10 
                   
                 0.7 
                 5.8 
               
               
                 1127 
                 9.5 
                   
                 3.7 
                 1 
               
               
                 1128 
                 &gt;10 
                   
                 &gt;10 
                 1.3 
               
               
                 1129 
                 1.9 
                   
                 &gt;10 
                 1 
               
               
                 1130 
                 2 
                   
                 5.5 
                 2 
               
               
                 1131 
                 2.2 
                   
                 9 
                 1.5 
               
               
                 1132 
                 2.6 
                   
                 3.9 
                 1.2 
               
               
                 1133 
                 6 
                   
                 &gt;10 
                 1.5 
               
               
                 1134 
                 2.4 
                   
                 1.6 
                 1 
               
               
                 1135 
                 3.6 
                   
                 7.5 
                 1.3 
               
               
                 1136 
                 2.9 
                   
                 5 
                 1.6 
               
               
                 1137 
                 &gt;10 
                   
                 3.5 
                 0.6 
               
               
                 1138 
                 &gt;10 
                   
                 &gt;10 
                 0.65 
               
               
                 1139 
                 3.7 
                   
                 6 
                 1.2 
               
               
                 1140 
                 3.5 
                   
                 4 
                 1.6 
               
               
                 1141 
                 &gt;10 
                   
                 &gt;10 
                 1.9 
               
               
                 1142 
                 &gt;10 
                   
                 &gt;10 
                 1.8 
               
               
                 1143 
                 &gt;10 
                   
                 &gt;10 
                 7.5 
               
               
                   
               
             
          
         
       
     
     Thus, compounds of the present invention are potent inhibitors of the growth and replication of the herpes viruses, including HCMV, VZV and HSV, effectively inhibiting viral yield. 
     In accordance with the present invention, compounds of the present invention may be administered to a patient suffering from a herpes virus, including HCMV, VZV and HSV in an amount effective to inhibit the virus. Compounds of the present invention are thus useful to ameliorate or eliminate the symptoms of the herpes virus infections in mammals including, but not limited to humans. 
     Compounds of the invention may be administered to a patient either neat or with a convention pharmaceutical carrier. 
     Applicable solid carriers can include one or more substances which may also act as flavoring agents, lubricants, solubilizers, suspending agents, fillers, glidants, compression aids, binders or tablet-disintegrating agents or an encapsulating material. In powders, the carrier is a finely divided solid which is in admixture with the finely divided active ingredient. In tablets, the active ingredient is mixed with a carrier having the necessary compression properties in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain up to 99% of the active ingredient. Suitable solid carriers include, for example, calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, methyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidine, low melting waxes and ion exchange resins. 
     Liquid carriers may be used in preparing solutions, suspensions, emulsions, syrups and elixirs. The active ingredient of this invention can be dissolved or suspended in a pharmaceutically acceptable liquid carrier such as water, an organic solvent, a mixture of both or pharmaceutically acceptable oils or fat. The liquid carrier can contain other suitable pharmaceutical additives such as solubilizers, emulsifiers, buffers, preservatives, sweeteners, flavoring agents, suspending agents, thickening agents, colors, viscosity regulators, stabilizers or osmo-regulators. Suitable examples of liquid carriers for oral and parenteral administration include water (particularly containing additives as above e.g. cellulose derivatives, preferably sodium carboxymethyl cellulose solution), alcohols (including monohydric alcohols and polyhydric alcohols e.g. glycols) and their derivatives, and oils (e.g. fractionated coconut oil and arachis oil). For parenteral administration the carrier can also be an oily ester such as ethyl oleate and isopropyl myristate. Sterile liquid carriers are used in sterile liquid form compositions for parenteral administration. 
     Liquid pharmaceutical compositions which are sterile solutions or suspensions can be utilized by, for example, intramuscular, intraperitoneal or subcutaneous injection. Sterile solutions can also be administered intravenously. Oral administration may be either liquid or solid composition form. 
     Preferably the pharmaceutical composition is in unit dosage form, e.g. as tablets or capsules. In such form, the composition is sub-divided in unit dose containing appropriate quantities of the active ingredient; the unit dosage forms can be packaged compositions, for example packeted powders, vials, ampoules, prefilled syringes or sachets containing liquids. The unit dosage form can be, for example, a capsule or tablet itself, or it can be the appropriate number of any such compositions in package form. 
     The therapeutically effective dosage to be used in the treatment of herpes virus infection must be subjectively determined by the attending physician. The variables involved include the the condition , age and weight of the patient. The novel method of the invention for treating herpes virus infection comprises administering to a subject, including humans, an effective amount of at least one compound of Formula 1 or a non-toxic, pharmaceutically acceptable salt thereof. The compounds may be administered orally, rectally, parenterally or topically to the skin and mucosa. The usual daily dose is depending on the specific compound, method of treatment and condition of the patient. The usual daily dose is 0.01-1000 mg/Kg for oral application, preferably 0.5-500 mg/Kg, and 0.1-100 mg/Kg for parenteral application, preferably 0.5-50 mg/Kg.