Abstract:
A diagnostic or prognostic method for detecting malignant and premalignant bladder cancer comprising the identification and quantification of an expression level of identified gene products in the body fluids of a patient and subsequently comparing the expression level of the patient to the expression level found in subjects that do not have bladder cancer.

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
       [0001]    This application claims the benefit under 35 USC §119(e) to U.S. provisional application Ser. No. 61/343,123 filed Apr. 23, 2010. 
     
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT 
       [0002]    The invention described herein was made with support of the U.S. Government, and the U.S. Government may have certain rights in the invention as provided for by the terms of grant numbers R21 CA116324 and N01 CN 85186 awarded by the National Institutes of Health (NIH) and the National Cancer Institute (NCI). 
     
    
     THE NAMES OF THE PARTIES TO A JOINT RESEARCH AGREEMENT 
       [0003]    Not Applicable. 
       INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC 
       [0004]    Not Applicable. 
       BACKGROUND OF THE INVENTION 
       [0005]    This invention provides biomarkers that can be used as diagnostics and/or prognostics for the detection of bladder cancer (also called urothelial cell carcinoma or UCC). More specifically, this invention describes gene products that have previously been shown to be detectable in urine or blood, which can be used in a simple diagnostic and/or prognostic test. These include gene products that are either up or down regulated and therefore would allow for the development of diagnostics that could control for protein concentration by including one or more from each class (up or down regulated) of gene product. Finally, gene products that are strongly upregulated are described that may represent markers for bladder premalignancy. Not only can noninvasive or minimally invasive diagnostic test be developed for assessing onset of bladder cancers, but such tests may also be used to determine the efficacy of a treatment. Furthermore, as the use of these tests in combination with various treatments occurs, a pattern of responsiveness of a treatment to specific gene product profiles may emerge allowing better choice of treatments. This invention can also be used to identify compounds that might be used to treat UCC by analyzing a compound&#39;s effect on gene expression patterns or by targeting a compound to a specific gene product to affect the change in said gene product associated with the disease. The compound can be a small molecule, an siRNA, a monoclonal antibody, a gene expression product or any other means of altering expression of the gene product. Finally, the biomarkers provided by the invention could be used as diagnostics and/or prognostics for screening at risk populations for UCC. At risk populations include current and former smokers and individuals exposed to occupational and environmental carcinogens. 
         [0006]    Bladder cancer causes substantial morbidity and mortality and has the 4th highest incidence of all cancers in the developed world, with an estimated 70,530 new cases predicted to occur in the US in 2010 [Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin 2010; 60:277-300]. More than 90% of bladder tumors are urothelial cell carcinomas (UCCs). At the time of their diagnosis, approximately 75% are superficial tumors, 20% are invading muscular layers (infiltrating or invasive UCCs) and 5% are already metastatic. Of the superficial cases, approximately 20% are cured by means of a single surgical intervention, whereas between 50 and 70% recur one or more times after surgery, but never become infiltrating tumors. Between 10 and 30% of these superficial tumors become infiltrating tumors. These tumors are aggressive, poor-prognosis tumors with a mortality after 5 years of 50% and in the metastasized cases, the mortality after two years is 100% [Sanchez-Carbayo M, Socci N D, Charytonowicz E et al. Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes. Cancer Res 2002; 62:6973-80; Adshead J M, Kessling A M, Ogden C W. Genetic initiation, progression and prognostic markers in transitional cell carcinoma of the bladder: a summary of the structural and transcriptional changes, and the role of developmental genes. Br J Urol 1998; 82:503-12; Babaian R J, Johnson O F, Llamas L, Ayala A G. Metastases from transitional cell carcinoma of urinary bladder. Urology 1980; 16:142-44]. The majority of newly diagnosed cases (˜⅔) are confined to the urothelium (do not breach the lamina propria) and are hence “superficial” or superficially invasive [Prout G R, Jr. Bladder carcinoma and a TNM system of classification. J Urol 1977; 117:583-90]. 
         [0007]    Current diagnosis systems are based on a combination of urinary cytology (from squamous cells in urine) and of the direct observation of the bladder by means of cystoscopy. The latter is actually the main diagnostic and follow-up technique for tumors. It is performed by transurethral route, therefore it is an invasive and rather unpleasant technique for the patients. The sensitivity and specificity of this technique were believed to be quite high, although improvements in the actual technique (fluorescence cystoscopy) indicate that this is probably not so and that part of the recurrence observed in superficial tumors could be due to the lack of total resection in non-visible parts thereof [Jones J S. DNA-based molecular cytology for bladder cancer surveillance. Urology 2006; 67:35-45]. 
         [0008]    Urinary cytology is in turn a non-invasive diagnostic technique with a high sensitivity and specificity for high-grade tumors. However, this technique shows limitations for detecting low-grade tumors [Bastacky S, Ibrahim S, Wilczynski S P, Murphy W M. The accuracy of urinary cytology in daily practice. Cancer 1999; 87:118-28]. Cytologic abnormalities of the urothelium are associated with carcinoma in situ (CIS), and urine cytology is positive in 90% of cases because of cell shedding into the urine due to loss of cellular adhesiveness. Also, CIS is frequently associated with synchronous urothelial tumors of any stage. Strong indirect evidence indicates this lesion is a likely precursor of invasive carcinoma, but direct evidence in humans is lacking [Bostwick D G, Ramnani D, Cheng L. Diagnosis and grading of bladder cancer and associated lesions. Urol Clin North Am 1999; 26:493-507]. Urothelial CIS has a high likelihood (&gt;80%) of progressing to invasive carcinoma if left untreated. Patients with UCC require frequent cystoscopic examination. If a tumor is found, treatment is transurethral resection (TUR) and intravesical treatment. Cystectomy is required for invasive UCC confined to the bladder [Sabichi A L, Lerner S P, Grossman H B, Lippman S M. Retinoids in the chemoprevention of bladder cancer. Curr Opin Oncol 1998; 10:479-84]. Traditional prognostic factors (tumor stage, and grade) do not sufficiently predict disease course or prognosis in the individual patient. Long-term study results clearly indicate that the ability to intervene at early stages and to monitor the success of treatment requires the definition of early markers for bladder cancer. Furthermore, the interpretation of the cytology is highly observer-dependent, therefore there may be inter-observer differences, especially in low-grade tumors. 
         [0009]    All these limitations have led to the search for more reliable non-invasive bladder cancer markers. There are a few commercially available urine based tests for screening and surveillance for bladder cancer, but none of these can detect premalignancy [Budman L I, Kassouf W, Steinberg J R. Biomarkers for detection and surveillance of bladder cancer. Can Urol Assoc J 2008; 2:212-21; Konety B, Lotan Y. Urothelial bladder cancer: biomarkers for detection and screening. BJU Int 2008; 102:1234-41]. Finding a non-invasive marker with a high sensitivity and specificity for bladder UCC would be very helpful for clinical practice. In fact, several studies describe new tumor markers in urine, such as the test for the bladder tumor antigen NMP22 [Wiener H G, Mian C, Haitel A, Pycha A, Schatzl G, Marberger M. Can urine bound diagnostic tests replace cystoscopy in the management of bladder cancer? J Urol 1998; 159:1876-80; Soloway M S, Briggman V, Carpinito G A et al. Use of a new tumor marker, urinary NMP22, in the detection of occult or rapidly recurring transitional cell carcinoma of the urinary tract following surgical treatment. J Urol 1996; 156:363-67], fibrin degradation products [Schmetter B S, Habicht K K, Lamm D L et al. A multicenter trial evaluation of the fibrin/fibrinogen degradation products test for detection and monitoring of bladder cancer. J Urol 1997; 158:801-5.], telomerase [Takihana Y, Tsuchida T, Fukasawa M, Araki I, Tanabe N, Takeda M. Real-time quantitative analysis for human telomerase reverse transcriptase mRNA and human telomerase RNA component mRNA expressions as markers for clinicopathologic parameters in urinary bladder cancer. Int J Urol 2006; 13:401-8], tests based on fluorescent in situ hybridization [Hailing K C, King W, Sokolova I A et al. A comparison of BTA stat, hemoglobin dipstick, telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine. J Urol 2002; 167:2001-6] or flow cytometry [Takahashi C, Miyagawa I, Kumano S, Oshimura M. Detection of telomerase activity in prostate cancer by needle biopsy. Eur Urol 1997; 32:494-98; Trott P A, Edwards L. Comparison of bladder washings and urine cytology in the diagnosis of bladder cancer. J Urol 1973; 110:664-66], but although most of them have a higher sensitivity than urinary cytology, the latter is still the most specific [Bassi P, De M, V, De Lisa A et al. Non-invasive diagnostic tests for bladder cancer: a review of the literature. Urol Int 2005; 75:193-200]. 
         [0010]    There has also been extensive effort in recent years aimed at identifying new genetic markers, small biomolecules, and proteins, as biomarkers for bladder cancer diagnosis, prediction of recurrence, as well as for surrogate endpoints in chemoprevention trials [Budman LI, Kassouf W, Steinberg JR. Biomarkers for detection and surveillance of bladder cancer. Can Urol Assoc J 2008; 2:212-21; Lodde M, Fradet Y. The detection of genetic markers of bladder cancer in urine and serum. Curr Opin Urol 2008; 18:499-503]. Ideally such biomarkers should be detectable by non-invasive means, should be accurate, sensitive and provide a viable alternative to cystoscopy, which is invasive and can have a sensitivity as low as 70% [Lam T, Nabi G. Potential of urinary biomarkers in early bladder cancer diagnosis. Expert Rev Anticancer Ther 2007; 7:1105-15]. In spite of the identification of several promising markers by several groups, none have yet been able meet these criteria [Shariat S F, Karakiewicz P I, Ashfaq R, et al. Multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy. Cancer 2008; 112:315-25; Harris L D, De La Cerda J, Tuziak T, et al. Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray. Mol Carcinog 2008; 47:678-85; Alvarez A, Lokeshwar V B. Bladder cancer biomarkers: current developments and future implementation. Curr Opin Urol 2007; 17:341-6]. Large numbers of reports on expression results of all tumor types have started to appear in the literature, including bladder tumors [Sanchez-Carbayo M, Socci N D, Charytonowicz E et al. Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes. Cancer Res 2002; 62:6973-80; Ramaswamy S, Tamayo P, Rifkin R et al. Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci USA 2001. 98:15149-54; Sanchez-Carbayo M, Socci N D, Lozano J J et al. Gene discovery in bladder cancer progression using cDNA microarrays. Am J Pathol 2003; 163:505-16; Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C. Tumor suppressor role of KiSS-1 in bladder cancer loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am J Pathol 2003; 162:609-17; Dyrskjot L, Thykjaer T, Kruhoffer M et al. Identifying distinct classes of bladder carcinoma using microarrays. Nat Genet 2003; 33:90-96], although most of the results have not been made public in their entirety. However, up until now, the studies which have been conducted with specific bladder cancer markers have been focused on one or on very few genes [Olsburgh J, Hamden P, Weeks R et al. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol 2003; 199:41-49; Fichera E, Liang S, Xu Z, Guo N, Mineo R, Fujita-Yamaguchi Y. A quantitative reverse transcription and polymerase chain reaction assay for human IGF-II allows direct comparison of IGF-II mRNA levels in cancerous breast, bladder, and prostate tissues. Growth Horm IGF Res 2000; 10:61-70; Simoneau M, Aboulkassim T O, LaRue H, Rousseau F, Fradet Y. Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9831. Oncogene 1999; 18:157-63]. Recently, [Alcaraz Asensio A, Mengual Brichs L, Burset Albareda, M, Ribal Caparros M. J., Ars Criach E. Bladder Cancer Diagnosis and/or prognosis Method. U.S. patent application Ser. No. 12/532,139] 14 bladder tumor marker genes were identified and used to develop a bladder cancer diagnosis and prognosis method based on the detection and quantification of the gene expression of these genes by means of quantitative real-time PCR in RNA extracted from bladder fluids. However this method suffers the limitation of requiring sufficient quantities of intact RNA, which is often not possible for samples that have not been rapidly processed. Therefore the search for non-invasive biomarkers (ie. in urine) demands a more guided approach. To this end we have combined the UPII-SV40Tag mouse model for bladder cancer progression with Affymetrix microarray technology to determine the gene transcription profiles of urothelium from the UPII-SV40Tag mice and age matched non-transgenic littermates (WT), at different times during the course of tumor development. 
         [0011]    In an attempt to generate a mouse model for bladder cancer progression, investigators in the laboratory of Xue-Ru Wu have engineered transgenic mice carrying a low copy number of the SV40 large T antigen (SV40Tag) oncogene, expressed under the control of the bladder urothelium specific murine uroplakin II promoter (UPII-SV40Tag mice) [Zhang Z T, Pak J, Shapiro E, Sun T T, Wu X R. Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Res 1999; 59:3512-7]. The SV40Tag oncogene can bind and inactivate the p53 and Rb tumor suppressor genes [Ahuja D, Saenz-Robles M T, Pipas J M. SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation. Oncogene 2005; 24:7729-45], both of which are frequently mutated in human bladder UCC [Cordon-Cardo C, Zhang Z F, Dalbagni G, et al. Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Res 1997; 57:1217-21]. In quiescent cells Rb is bound to E2F family transcription factors, suppressing their ability to activate transcription of genes required for DNA replication, nucleotide metabolism, DNA repair and cell cycle progression [Ahuja D, Saenz-Robles M T, Pipas J M. SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation. Oncogene 2005; 24:7729-45; Dimova D K, Dyson N J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005; 24:2810-26]. SV40T blocks the Rb-mediated repression of E2F proteins, thereby inducing expression of E2F-regulated genes such as cyclins E, A and D1, chk1, fen1, BRCA1 and many others. UPII-SV40Tag mice develop a condition closely resembling human CIS starting as early as 6 weeks of age. This condition eventually progresses to invasive UCC from 6 months of age onward. Histological examination of the bladder CIS lesions closely mimics the human histology [Zhang Z T, Pak J, Shapiro E, Sun T T, Wu X R. Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Res 1999; 59:3512-7]. 
         [0012]    Using this model, we have identified approximately 1,900 unique genes differentially expressed (≧3-fold difference at one or more time points) between WT and UPII-SV40Tag urothelium during the time course of tumor development. Among these, there were a high proportion of cell cycle regulatory genes and proliferation signaling genes that were more strongly expressed in the UPII-SV40Tag bladder urothelium. 
       SUMMARY OF THE INVENTION 
       [0013]    The invention features a diagnostic for detecting bladder cancer through noninvasive or minimally invasive techniques. More specifically, this invention provides a list of gene products that are increased or decreased in UCC and/or bladder premalignancy which can be used to develop diagnostics and/or prognostics for early detection of bladder cancer using urine or blood samples. 
         [0014]    In one aspect the invention, ˜1,900 gene products that are either up or down regulated by at least three-fold in the mouse model are disclosed. Gene products that are upregulated during progression to malignancy include gene products encoding centromere proteins (Cenpa, Cenpf, Cenph; Aurora kinases A and B), cyclins (ccnb1, ccnb2, ccne2, ccna2 and ccnf); cell division cycle proteins (Cdc7, Cdc2a, Cdc20, Cdc6, Cdca3); kinesin-like family proteins, (kifc1, kif2c, kif11, kif20a, kif 22, kif23), multiple minichromosome maintenance deficient proteins (MCM2,4,5,6,7.8, and 10), and other proliferation related proteins such as E2f8, Spbc24, Top2a, Brca1, RacGAP1, RHAMM, and others. Gene products that are suppressed in mice with bladder carcinoma when compared to controls include extracellular matrix proteins (collagens Col1a1, Col1a2, Col6a2, Col3a1, laminin B1, and tenascin C), keratins (krt2-5, krt1-15 and other intermediate filament proteins) Dmn, Vim; as well as uroplakins upk1b and upk2, and other tight junction proteins (cldn8, ctnnb1, ctnnal1, ctnnd2, pcdhgc3, and cgnl1), superoxide dismutase 3 (SOD3), cyclin D2 (ccnd2), transthyretin (Ttr), bone morphogenetic protein 2 (BMP2), and matrix metalloproteinase 2 (Mmp2). One or more of these gene products can be used as a biomarker to detect changes indicative of premalignancy or malignancy. Table 1 provides a full list of such genes or gene products. 
         [0015]    In yet another aspect of the foregoing invention, the genes or gene products can be used to define biological networks, which can be further used to develop diagnostics for bladder cancer progression. Thirty networks were identified that occurred at each of the time points assessed during tumor progression. Table 2 provides a list of all biological networks. Early events in cancer progression as observed in the top three biological networks centered on JUN, ERK, and P21. Said pathways that are identified early in the progression process (3 weeks) could be used to develop diagnostics for premalignancy. In addition, one or more of JUN, ERK and P21 genes or gene products can be used in diagnosis of premalignancy. 
         [0016]    In the foregoing aspects of the invention, one or more of the gene products that are up regulated during premalignancy or malignancy can be detected with one or more of the gene products that are down regulated during premalignancy or malignancy. Detection of the gene products can be carried out using standard diagnostic methods such as q-rtPCR or ELISA. Other methods for detecting specific RNAs or proteins in blood or urine can also be used. By using a combination of gene products that are up regulated and down regulated during progression to cancer, better control for sample variability can be achieved. Fluids collected from a subject are used to detect and quantify the expression pattern of one or more gene products, then comparing the results obtained with normal reference values for said gene products in blood or urine. 
         [0017]    In another aspect of this invention, the above described gene products (Table 1), biological networks (Table 2) and JUN, ERK, P21, can be used alone or in combinations to determine the efficacy of a treatment. A patient can be treated with, for example transurethral resection for superficial UCC followed by immunotherapy with Bacillus Calmette-Guérin (BCG), and a change in one or more gene products can be analyzed at various times following treatment to ensure that the desired efficacy is achieved. 
         [0018]    In the foregoing aspect of the invention, said gene products can also be correlated with responsiveness to a given treatment such that this invention can be used to predict the best treatment for a patient. For example, analysis of treatment responsiveness may demonstrate that patients with changes in a subset of gene products at diagnosis respond better to treatment A, whereas patients with a different pattern of gene product changes respond better to treatment B. 
         [0019]    Additionally, this invention can be used to find new molecules for treatment of bladder cancer. Screening can be carried out in cell lines or in animals that have altered expression of said gene products to identify compounds that can return expression levels back to normal or alter them in the direction of normal levels. Changes in key gene products associated with biological pathways can also be used for this purpose. Compounds can be small molecules, or to repress critical gene products in a pathway, siRNAs or monoclonal antibodies; or to enhance key gene products, a gene therapy expression system or a recombinant protein. 
         [0020]    Finally, this invention can be used to provide diagnostics and/or prognostics for screening at risk populations for UCC, on a large scale. 
         [0021]    By “biological pathway or pathway” is meant broadly as a group of functionally interrelated genes and gene products. 
         [0022]    By “biomarker” is meant any RNA or protein that can be quantified from blood or urine fluids. 
         [0023]    By “bladder cell carcinoma or bladder cancer” is meant any cancers that originate in the bladder. 
         [0024]    By “blood samples” is meant any whole or part of material drawn from a patients vein, including whole blood, serum, or plasma. 
         [0025]    By “compound” is meant any molecule, protein, antibody or nucleic acid that can be administered to a cell, animal or subject to assess changes in expression, tumorgenicity or phenotypic changes. 
         [0026]    By “diagnostic test” is meant any kind of medical test performed to aid in the diagnosis or detection of disease. 
         [0027]    By “down regulated” is meant a reduction in expression of a gene product in a bladder cancer subject by at least 3-fold from that found in non-bladder cancer patients. 
         [0028]    By “gene products” is meant an mRNA or a protein encoded by a specific gene. 
         [0029]    By “malignancy” is meant, in reference to a tumor that is cancerous, that can invade and destroy nearby tissue, and that may spread (metastasize) to other parts of the body. 
         [0030]    By “premalignancy” is meant a disease, syndrome, or finding that, if left untreated, may lead to cancer. 
         [0031]    By “up-regulated” is meant an increase in expression of a gene product in a bladder cancer subject by at least 3-fold from that found in non-bladder cancer patients. 
         [0032]    By “urothelial cell carcinomas or UCCs” is meant cancers that originate in the cells that line the bladder called urothelial cells. Formerly called transitional cell carcinoma (TCC). 
         [0033]    By “treatment or treating” is meant the medical management of a subject, e.g. an animal or human, with the intent that a prevention, cure, stabilization, or amelioration of the symptoms or condition will result. This term includes active treatment, that is, treatment directed specifically toward improvement of the disorder; palliative treatment, that is, treatment designed for the relief of symptoms rather than the curing of the disorder; preventive treatment, that is, treatment directed to prevention of disorder; and supportive treatment, that is, treatment employed to supplement another specific therapy directed toward the improvement of the disorder. The term “treatment” also includes symptomatic treatment, that is, treatment directed toward constitutional symptoms of the disorder. “Treating” a condition with the compounds of the invention involves administering such a compound, alone or in combination and by any appropriate means, to an animal, cell, lysate or extract derived from a cell, or a molecule derived from a cell. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0034]    The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee. 
           [0035]      FIG. 1  is H&amp;E stain (panels a, d, and g) and MR images (b, c, e, f, h, and i) of the bladders of wild type littermates (WT, a-c) and transgenic mice at 6 weeks (d-f) and 38 weeks (gi) of age. Arrows indicate a thickened mucosa in early stage UCC (f) and invasion into surrounding tissue for advanced UCC (h, i). Panels a, d and g were photographed at 100× magnification. 
           [0036]      FIG. 2  represents a preliminary hierarchical clustering of all four time points in the UPII-SV40Tag microarray analysis study: 3, 6, 20, and 30 weeks. The colors red, green, and black represent genes that are upregulated, downregulated, or no change, respectively, in the UPII-SV40Tag mice when compared to the WT littermates. The last cluster, cluster 8, has been enlarged and rescaled and represents genes that are highly upregulated at all four time points. 
           [0037]      FIG. 3 , panel A, selected genes that were expressed at higher levels in UPII-SV40Tag urothelium relative to WT littermates are shown. Black bars indicate raw expression values for UPII-SV40Tag mice (n=2). Open bars indicate expression values for WT mice. 
           [0038]      FIG. 3 , panel B are selected genes that were expressed at lower levels in UPII-SV40Tag urothelium relative to WT littermates. 
           [0039]      FIG. 4  represents confirmation of microarray data for selected genes. RT-PCR was performed using the cDNA made from RNA extracted from the urothelium of 6 week old WT and 3 week old hemizygous mice (+/−) SV40Tag mice. 
           [0040]      FIG. 5  are gene interaction networks #1-3. Gene expression profiles of 3 week old WT and UPII-SV40Tag bladder urothelial tissue (n=2 for each group) were compared using Ingenuity microarray analysis software. Genes overexpressed and underexpressed in UPII-SV40Tag bladders compared to WT mice, at the 3 week time point, are shown in red and green, respectively. 
           [0041]      FIG. 6 , panel A are differentially expressed genes in human bladder derived cells. Semiquantitative RT-PCR of 25, 30, and 35 cycles was performed on four human bladder cell lines using primers for four of the genes identified from the UPII-SV40Tag mouse microarray experiment. The relative expression was determined by a ratio of each sample to the most intense sample for that gene, which was assigned a value of one. 
           [0042]      FIG. 6 , panel B are immunohistochemical detection of differentially expressed genes in paraffin sections of superficial bladder UCC. Sections were probed with antibodies for the indicated proteins and detected colorimetrically using horseradish peroxidase-coupled secondary antibodies, except for the RacGAP1 20X and RHAMM 40X panels which were detected by fluorescently tagged secondary antibodies. 
           [0043]      FIG. 7 , The Kaplan-Meier estimates by RacGAP1/PCNA and RHAMM (also called Hmmr). Panel A are Kaplan-Meier estimates by level of combinations of RacGap and PCNA, where significant differences in recurrence-free survival can be found among the 4 subsets of patients (p-value=0.0071, log-rank test, 0=low 1=high). Panel B, shows the comparison of recurrence-free survival between RHAMM Low and High groups at visit 0 for male patients on treatment arm with tumor stage equal to T1 or TA and average tumor grade equal to 1, 2, or 3. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0044]    This invention describes a comprehensive gene expression profile of bladder premalignancy. This is part of our long term effort to identify biomarkers of the earliest stages bladder UCC, which could potentially predict occurrence and recurrence of bladder UCC. A more immediate aim of these studies is to identify potential biomarkers of early stage bladder UCC, which can be tested in patient urine, bladder wash and other tissue samples. We have identified approximately 1,900 genes that are differentially expressed (&gt;3-fold higher or lower) between the bladder urothelium of UPII-SV40Tag mice and their age-matched WT littermates at ages that encompass early stage changes that precede the appearance of CIS (3 weeks), CIS (6 weeks), and early and later stage UCC (20 and 30 weeks, respectively). 
         [0045]    A large proportion of the genes upregulated in the UPII-SV40Tag urothelium are cell cycle regulatory and proliferation signaling genes. Many of these genes are common with the SV40T/t-antigen cancer signature identified recently by the laboratory of J. E. Green and collaborators, [Deeb K K, Michalowska A M, Yoon C Y, et al. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res 2007; 67:8065-80]. These investigators used DNA microarrays to compare three transgenic mouse models for breast, lung, and prostate cancer, all based on tissue specific expression of SV40Tag, and found a common set of differentially expressed genes that are involved in cell proliferation, DNA repair and apoptosis. Of the 119 genes that comprise this T/t-antigen signature, 73 are found in our list of ˜1,900 differentially expressed genes (61% identity), suggesting similarity between models. Most importantly, this same signature of genes was associated with the most aggressive tumor phenotype and poor prognosis in human breast, lung, and prostate cancer [Deeb K K, Michalowska A M, Yoon C Y, et al. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res 2007; 67:8065-80]. Whether the same association exists with human bladder UCC remains to be determined. In addition to over-expressed genes, we have identified several genes that are suppressed in the UPII SV40Tag bladders relative to WT littermates. This includes structural and cell adhesion genes that appear to be related to the normal differentiated state of urothelium. These include genes encoding extracellular matrix proteins, intermediate filament proteins, as well as uroplakins and other tight junction proteins. Table 1 contains the full list of genes that were found to by differentially expressed (≧3-fold at one or more time points) between UPII-SV40Tag and WT littermate urothelium. 
         [0046]    We used the Ingenuity Pathways Analysis software package to analyze the microarray data sets in order to identify the predominant cellular functions and signaling pathways that distinguish the earliest accessible stage of bladder UCC in the UPII-SV40T model. When we examined the biological networks that are derived from the 1,900 differentially expressed gene list, we noted that the top scoring networks contain genes involved in cell cycle, DNA replication, recombination, and repair, cancer, cellular movement, and cellular assembly and organization. The three highest scoring networks center on the activator protein 1(AP-1) transcription factor subunit, JUN; the MAP kinase extracellular signal-regulated kinase, ERK, and the cyclin dependent kinase inhibitor, P21 ( FIG. 5 ). These are regulators of proliferative responses and are part of linked pathways all known to be affected by oncogenic mutations [Dhillon A S, Hagan S, Rath O, Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007; 26:3279-90]. AP-1 is a positive regulator of cell proliferation and transformation and its activity is stimulated in mouse skin tumorigenesis models by the tumor promoter TPA (12-O-tetradecanoylphorbol-13 acetate) [Angel P, Szabowski A, Schorpp-Kistner M. Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 2001; 20:2413-23]. A direct link between between MAPK signaling and AP-1 activity has been established from studies in which kinase deficient forms of ERK could inhibit AP-1 activation by several stimuli [Frost J A, Geppert T D, Cobb M H, Feramisco J R. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12- myristate 13-acetate, and serum. Proc Natl Acad Sci USA 1994; 91:3844-8; Watts R G, Huang C, Young M R, et al. Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Oncogene 1998; 17:3493-8]. Those findings have led to several studies, including our own, aimed at understanding the mechanism of suppression of MAP kinase signaling and/or AP-1 activity by the vitamin A metabolite all-trans retinoic acid (ATRA), an efficient suppressor of tumor formation in several epithelial cancer models [Niles R M. Signaling pathways in retinoid chemoprevention and treatment of cancer. Mutat Res 2004; 555:81 96; Cheepala S B, Yin W, Syed Z, et al. Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion. Mol Cancer 2009; 8:27; Cheepala S B, Syed Z, Trutschl M, Cvek U, Clifford J L. Retinoids and skin: Microarrays shed new light on chemopreventive action of all-trans retinoic acid. Mol Carcinog 2007; 46:634-9]. Our recent studies have shown that the B-Raf/Mek/Erk MAP kinase pathway is a target for the chemopreventive activity of ATRA in the mouse 2-stage skin carcinogenesis model. The present gene network analysis suggests that this same pathway could also be a target for prevention of bladder UCC, and will guide future experiments for testing potential chemopreventive and/or therapeutic drugs such as ATRA. 
         [0047]    While any of the ˜1,900 gene products identified in this study (shown in Table 1) can be used alone or in combination with other gene products, including a combination that may include one or more gene products that have increased expression during bladder carcinoma with one or more gene products whose expression is decreased in bladder cancer patients, 962 were previously identified as bladder genes (Table 3), representing potential biomarkers for bladder carcinomas since their expression has already been linked to the bladder. To develop a non-invasive or minimally invasive diagnostic, gene products preferably would be found on the cell surface or would be secreted proteins. Of the identified gene products, 244 are known to be expressed on the cell surface and 119 are secreted. A total of 242 bladder-expressed gene products have previously been reported to be cell surface or secreted proteins (Table 3, gene products previously reported to be cell surface or secreted proteins denoted with a “*” symbol). These 242 gene products can be used alone or in combination with one or more of the other 242 gene products for the development of bladder carcinoma diagnostics and/or prognostics, preferably including one or more of the gene products whose expression is increased in bladder carcinoma together with one or more of the gene products whose expression is decreased in bladder carcinoma. 
         [0048]    In addition to having cell surface expression or in being a secreted protein, a non-invasive or minimally invasive diagnostic should be readily assayed in bodily fluids, such as blood or urine. Of the ˜1,900 gene products identified, 229 have been previously detected in the urine and 552 in the blood. Of the 242 bladder cancer gene products known to be cell surface associated or secreted, 159 have previously been detected in the blood or serum (Table 4) and therefore could be used alone or in combination with one or more of the other 159 gene products for the development of bladder carcinoma diagnostics and/or prognostics, preferably including one or more of the gene products whose expression is increased in carcinoma together with one or more of the gene products whose expression is decreased in bladder carcinomas. 
         [0049]    A similar analysis of gene products associated with bladder cancer was recently carried out [Alcaraz Asensio A, Mengual Brichs L, Burset Albareda, M, Ribal Caparros M. J., Ars Criach E. Bladder Cancer Diagnosis and/or prognosis Method. U.S. patent application Ser. No. 12/532,139]. In this study, 384 gene products were shown to be differentially expressed between tumor samples and control specimens. When these gene products were compared to the 159 bladder cancer gene products known to be cell surface associated or secreted and which have previously been detected in the blood or serum identified in this invention, only 17 were found to be in common. Thus, 142 new gene products (Table 5) have been identified that may be used alone or in combination with one or more of the other 142 novel gene products for the development of bladder carcinoma diagnostics and/or prognostics, preferably including one or more of the gene products whose expression is increased in carcinoma together with one or more of the gene products whose expression is decreased in bladder carcinomas. While the above represent the most current information on cell surface or secreted bladder cancer gene products found in the blood or urine, analysis of blood or urine samples can lead to identification of other gene products from the ˜1,900 identified in this study, which would also be useful in the practice of this invention. Similarly, additional bladder gene products from Table 1 may be identified as being expressed in the bladders from normal subjects or patients with bladder cancer, and would also be useful in the practice of this invention. 
         [0050]    In an effort to narrow our candidate list of biomarkers to those most likely to be involved in the earliest stages of UCC, we have also focused on genes differentially expressed at the 3 week time point. Amongst these genes, we have further focused on those which also remain highly differentially expressed at later time points, with the expectation that such genes could also serve a markers for later stage UCC ( FIG. 2 , left panel). Also, in order to increase the likelihood of detection by antibodies in urine samples, we are paying closest attention to proteins that are secreted or are known to reside in the plasma membrane, and with some exceptions, those which have been previously detected in urine or bladder tissue by other investigators. These in include hyaluronan mediated motility receptor (Hmmr/RHAMM), which has been identified as highly expressed in early stage (Ta, T1), and later stage (T2-4) bladder UCC [Kong Q Y, Liu J, Chen X Y, Wang X W, Sun Y, Li H. Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncol Rep 2003; 10:51-5]; proliferating cell nuclear antigen (PCNA) [Inagaki T, Ebisuno S, Uekado Y, et al. PCNA and p53 in urinary bladder cancer: correlation with histological findings and prognosis. Int J Urol 1997; 4:172-7], autocrine motility factor receptor (AMFR) [Korman H J, Peabody J O, Cerny J C, Farah R N, Yao J, Raz A. Autocrine motility factor receptor as a possible urine marker for transitional cell carcinoma of the bladder. J Urol 1996; 155:347-9] and others. We have tested for expression of several candidate genes that are upregulated in UPII-SV40Tag mice at all 4 time points (RacGAP1, PCNA, Survivin, and RHAMM), are upregulated and secreted (IL18) and are upregulated and expressed at the cell surface (PON3), in paraffin sections of high and low grade superficial bladder UCC samples. We detect all of these proteins to varying degrees in the tumor samples, with the highest levels detectable for RacGAP1, PCNA and RHAMM ( FIG. 6B ). This data, while preliminary, provides strong support for further testing and validation of these genes as biomarkers for superficial (early stage) UCC. We have also begun testing for expression of these proteins in urine samples from a recently completed Phase II, randomized, placebo controlled chemoprevention trial (N01 CN85186, PI: A. Sabichi) that was designed to test whether celecoxib can prevent recurrence in patients successfully treated by TUR for non-muscle invasive bladder cancer. In this trial, urine samples were collected over the course of treatment every 3 months for 18 months after curative therapy (TUR plus BCG), or until the time of recurrence (˜30% of patients). Analysis of urine samples for 99 patients demonstrates a correlation between high protein levels of RacGAP1 (data not shown) and a combination of RacGAP1 and PCNA, with recurrence ( FIG. 7A ). If patients had high levels of both RacGAP1 and PCNA their recurrence-free survival probability was about 40% (highly significant: Log-rank p=0.0071). We also found a subgroup of patients, Celecoxib treated males with any grade stage T1 or Ta bladder cancer, in which high levels of RHAMM correlated with recurrence (p=0.0898) ( FIG. 7B ). The data for the complete analysis of AMFR, RacGAP1, RHAMM, and PCNA for all 99 patients at different time points during the chemoprevention trial is shown in Table 6. 
         [0051]    It is anticipated that single markers or combinations of markers can be validated for prediction of recurrence, and possibly for prediction of response to therapy. In the future we will also focus attention on proteins predicted to be downregulated in premalignant urothelium, such as uroplakin II, collagen 1A2 (Col1a2), bone morphogenetic protein 2 (BMP2), and superoxide dismutase 3 (SOD3). These could serve as negative markers for recurrence. 
         [0052]    We have identified genes that are differentially expressed in premalignant urothelia, in a mouse model for aggressive bladder UCC. This group of genes now serves as a promising pool of candidates for biomarkers for early stage UCC, as well as a source for gaining insight into the earliest events preceding early stage UCC and/or CIS. These gene products can also be used for targeting therapies to protect against bladder cancer or for the treatment of bladder cancer. For example, one or more gene products in Table 1 that are overexpressed in bladder carcinomas could be used to screen for small molecules that suppress its (their) expression or inhibit its (their) activity. Similarly, monoclonal antibodies, siRNAs or antisense molecules can be developed to inhibit the activity of these over expressed gene products Likewise, therapeutic strategies such as recombinant proteins or gene therapy can be employed to compensate for one or more gene products that are inhibited in bladder carcinoma. 
       Examples 
     The UPII-SV40Tag Model Recapitulates Invasive Bladder UCC 
       [0053]    In this study we have used the UPII-SV40Tag mouse model of bladder cancer progression, in combination with comprehensive DNA microarray analyses, to explore early events in the development of bladder cancer, and to identify potential biomarkers for bladder premalignancy. An initial goal was to better characterize the earliest macroscopic changes in bladder tissue in live UPII-SV40Tag mice using small animal magnetic resonance (MR) imaging techniques developed at the MD Anderson Cancer Center&#39;s experimental animal imaging facility. We scanned and subsequently sacrificed mice at ages ranging from 6 weeks to 12 months of age, and compared MR image and histopathologic assessment of the genitourinary tract. An example of axial T1 postcontrast and T2 MR images of the urinary bladder of a 6 week old mouse that showed moderate irregular thickening of the urinary bladder mucosa which corresponded to histological findings of diffuse hyperplasia of the transitional epithelium is shown in  FIG. 1  ( FIG. 1   d - f ). At 38 weeks of age, MR imaging identified large, irregular contrast enhancing masses within the bladder lumen, some of which had invaded into the surrounding abdominal cavity ( FIG. 1 , h, i, arrows). These tumors were carcinoid in appearance and without the delicate papillae that characterize papillary tumors. We found a close correlation between MR image and histologic detection of intravesical abnormalities in the mice in all age groups ( FIG. 1 , compare a, d, and g to other panels). 
       Gene Expression Profile of Bladder Cancer Progression 
       [0054]    In parallel with the histologic and macroscopic characterization, we used Affymetrix DNA microarray technology to compare the gene transcription profiles of normal bladder urothelium (from non-transgenic littermates) with the urothelium of the UPII-SV40Tag mice, over time. We chose to examine mice at 3, 6, 20 and 30 weeks of age. These times for comparison encompass early stage changes that precede the appearance of CIS (3 weeks), CIS (6 weeks), and early and later stage UCC (20 and 30 weeks, respectively). Our determination of genes expressed in the urothelium at these time points revealed approximately 1,900 unique differentially expressed (≧3-fold difference) genes at one or more of the time points between the urothelium of UPII-SV40Tag mice and their age matched wild type (WT) littermates (see Table 1 for the full list).  FIG. 2  illustrates the clustering of the differentially expressed genes according their expression patterns over the time course. Genes more highly expressed in the UPII-SV40Tag bladders are shown in red and genes more strongly expressed in WT bladders are shown in green. Black bars indicate genes that are expressed at similar levels in both mouse lines for that time point. We focused attention on a group of genes with a high fold increase in expression in UPII-SV40Tag mice for all 4 time points ( FIG. 2 , expanded left panel). We reason that this group of genes could contain candidate biomarkers for both premalignant and later stage UCC. The time course of expression of some of the most strongly upregulated and downregulated genes are shown graphically ( FIG. 3A , higher expression in UPII-SV40Tag;  FIG. 3B , lower expression in UPII-SV40Tag). 
         [0055]    Interestingly some genes, like BRCA1, were strongly expressed in premalignant urothelium only at early stages of progression, with levels eventually dropping to near normal by later stages. We note a high proportion of genes involved in cell proliferation amongst the upregulated genes, and several structural and differentiation-related genes were among the downregulated genes. The microarray results were confirmed independently by RT-PCR for several of the genes ( FIG. 4 ). For all genes tested to date, the relative direction of expression between WT and UPII-SV40Tag bladders was the same for both the RT-PCR and microarray results. 
       Gene Network and Pathway Analysis 
       [0056]    We next performed biometric analysis using the Path Explorer function in the Ingenuity Pathways Analysis software package (Ingenuity Systems Inc.) on the list of 1,900 differentially expressed genes (≧3-fold up or down at 1 or more time points), considering the expression differences between WT and UPII-SV40Tag mice separately for each time point. There was an average of 45 biological networks generated for the gene lists for each time point. Biological networks are defined as highly connected networks of up to 35 genes. A significance score based on a p-value calculation is assigned to each network and is displayed as a negative log of the p-value. The higher the score, the less likely it is that the set of genes from our list appearing in the network (focus genes) could be explained by random chance alone. See Table 2 for a full list of networks, their significance scores, number of focus molecules, relative direction of expression, and their top functions. The 30 top scoring gene networks were identical for all time points, although not all gene changes were the same in each network for each time point. This similarity between time points is expected since the same 1,900 gene list was used for each analysis, with only the fold difference between WT and UPIISV40Tag varying between sets. The similarity indicates that most of the major gene expression changes start to take place as early as 3 weeks. It should be noted that the 3 week time point precedes the appearance of invasive UCC by several weeks, such that gene expression differences at this time could be considered representative of a premalignant state. The top scoring networks contain genes involved in cell cycle, DNA replication, recombination, and repair, cancer, cellular movement, and cellular assembly and organization. The merged image of the top 3 networks for the 3 week time point indicates three nodes centered on JUN, ERK, and P21, all key regulators of proliferative responses ( FIG. 5 ). Some of the other genes that are upregulated in UPII-SV40Tag mice include those encoding centromere proteins Cenpa, Cenpf, Cenph; Aurora kinases A and B; cyclins ccnb1, ccnb2, ccne2, ccna2 and ccnf; cell division cycle proteins Cdc7, Cdc2a, Cdc20, Cdc6, Cdca3; kinesin-like family proteins, kifc1, kif2c, kif11, kif20a, kif 22, kif23; multiple minichromosome maintenance deficient proteins MCM2,4,5,6,7.8, and 10; other proliferation related proteins such as E2f8, Spbc24, Top2a, Brca1, RacGAP1, RHAMM, and others ( FIG. 2 ,  FIG. 5 , and Table 1). Many of these genes are common with the SV40T/t-antigen cancer signature identified recently by Deeb et al, for human breast, prostate, and lung carcinomas. In addition, we have identified several genes that are suppressed in the UPII-SV40Tag bladders relative to wild type littermates, which includes a large proportion of structural and cell adhesion genes that appear to be related to the normal differentiated state of urothelium. Examples are genes encoding extracellular matrix proteins such as collagens Col1a1, Col1a2, Col6a2, Col3a1, laminin B1, and tenascin C; keratins krt2-5, krt1-15 and other intermediate filament proteins Dmn, Vim; as well as uroplakins upk1b and upk2 itself, and other tight junction proteins cldn8, ctnnb1, ctnnal1, ctnnd2, pcdhgc3, and cgnl1. Other downregulated genes that are potentially involved in the development of UCC include superoxide dismutase 3 (SOD3), cyclin D2 (ccnd2), transthyretin (Ttr), bone morphogenetic protein 2 (BMP2), and matrix metalloproteinase 2 (Mmp2). As in  FIG. 1 , red and green indicates higher expression in the UPII-SV40Tag and WT bladders, respectively. 
       Differentially Expressed Genes in Human Bladder-Derived Cell Lines and in Human Superficial Bladder Cancer 
       [0057]    Finally, we have attempted to determine the relevance of several of the differentially expressed genes to human bladder cancer. We first compared mRNA expression levels for several genes in human normal urothelial cells (primary HUCs), ‘premalignant’ urothelial cells (SV-HUC) and advanced UCC cells (UM-UC-10, UM-UC-13). We have recently described the UM-UC cells in detail (21). The UM-UC-10 cells were derived from a bladder tumor, have mutant p53, undetectable levels of Rb, and are nontumorigenic in nude mice. The UM-UC13 cells were derived from a lymphatic metastasis, also have mutant p53 and undetectable RB, but are tumorigenic in nude mice. We observed that more than half of the genes tested by semi-quantitative RT-PCR were expressed as predicted in the human cell lines, such that genes overexpressed in the UPIISV40Tag mice were more strongly expressed in the premalignant and malignant cell lines ( FIG. 6A  and data not shown). Conversely, Ccnd2, which was downregulated in the UPII-SV40Tag mice, is expressed only in the primary HUCs. 
         [0058]    Next we tested the expression of several differentially expressed genes in paraffin sections of high and low grade superficial bladder UCC samples that were excised by transurethral resection. We prioritized biomarkers for initial testing based on whether the genes were found to be highly expressed at all 4 time points (PCNA, Survivin, RHAMM, RacGAP1) as shown in  FIG. 2 , left panel; are cell surface proteins (PON3), or are secreted (IL18). We reason that such proteins would also have a higher likelihood of being detectable in urine. To date we have tested expression of 6 proteins in tumor samples from 12 patients (6 high grade and 6 low grade). All 6 of these proteins were detectable by immunohistochemical staining in the patient samples, with the strongest expression detected for RacGAP1, PCNA, and RHAMM ( FIG. 6B , and data not shown). This expression also co-localized with expression of cytokeratin 19 (K19), a urothelial marker. RHAMM is expressed evenly throughout the cytoplasm, while PCNA is strongly expressed in the nuclei of hyperplastic urothelial cells, as previously described by others ( FIG. 6B , lower row) [Kong Q Y, Liu J, Chen X Y, Wang X W, Sun Y, Li H. Differential expression patterns of hyaluronan receptors CD44 and RHAMM in transitional cell carcinomas of urinary bladder. Oncol Rep 2003; 10:51-5; Inagaki T, Ebisuno S, Uekado Y, et al. PCNA and p53 in urinary bladder cancer: correlation with histological findings and prognosis. Int J Urol 1997; 4:172-7]. We note that RacGAP1 is expressed in the cytoplasm, with prominent focal perinuclear staining, which is in agreement with our own immunocytochemical staining of bladder UCC cell lines (data not shown). It is not yet possible to determine whether there is a statistically significant difference in expression for any of the markers between high and low grade UCC due to the low sample size. 
         [0000]    RHAMM, RacGAP1 and PCNA are potential urine biomarkers for premalignancy. 
         [0059]    We have tested for expression of RacGAP1, RHAMM, and PCNA in urine samples from a recently completed Phase II, randomized, placebo controlled chemoprevention trial (N01 CN85186). That trial was designed to test whether Celecoxib, a selective COX-2 inhibitor, can prevent recurrence in patients successfully treated by TUR for non-muscle invasive bladder cancer. Urine samples were collected over the course of treatment every 3 months for 18 months after curative therapy (TUR and BCG), or until the time of recurrence (˜30% of patients). Analysis of urine samples for 99 patients demonstrates a correlation between high protein levels of RacGAP1 and PCNA at the baseline time point of the study (6 weeks after curative therapy), with recurrence ( FIG. 7A ). Over 60% of patients with high levels of both of these proteins had a recurrence of UCC within 18 months of curative therapy. 
         [0060]    RHAMM expression at the baseline time point of the study also correlated with recurrence. However, this result was most striking in a subgroup of patients, the Celecoxib treated males with any grade stage T1 or Ta UCC (p=0.0898 comparing low to high RHAMM groups) ( FIG. 7B ). These results are promising and provide incentive for further testing of these biomarkers. 
         [0061]    All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each independent publication or patent application was specifically and individually indicated to be incorporated by reference. While the invention has been described in connection with specific embodiments thereof, it will be understood that it is capable of further modifications and this application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure that come within known or customary practice within the art to which the invention pertains and may be applied to the essential features hereinbefore set forth, and follows in the scope of the claims. In short, it is the applicant&#39;s intention that the scope of the patent issuing herefrom will be limited only by the scope of the appended claims. 
         [0000]    
       
         
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Gene Symbol 
                 3 wk 
                 1.5 mo 
                 5 mo 
                 7 mo 
               
               
                   
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 Aasdhppt 
                 −0.5 
                 −0.3 
                 −0.7 
                 −1.16 
               
               
                   
                 Aatf 
                 −0.3 
                 0 
                 −0.22 
                 −1.89 
               
               
                   
                 Abca1 
                 −0.01 
                 0.42 
                 −0.85 
                 −1.84 
               
               
                   
                 Abca3 
                 −0.49 
                 −0.52 
                 −0.42 
                 −1.05 
               
               
                   
                 Abcb8 
                 0.33 
                 0.7 
                 −0.04 
                 −1.32 
               
               
                   
                 Abcc3 
                 −0.76 
                 −1.03 
                 −1.14 
                 −1.37 
               
               
                   
                 Abhd10 
                 0.67 
                 1.32 
                 0.6 
                 0.7 
               
               
                   
                 Abhd12 
                 −0.13 
                 0.02 
                 −0.43 
                 −1.3 
               
               
                   
                 Abhd14b 
                 −1.3 
                 −0.88 
                 −0.66 
                 −0.74 
               
               
                   
                 Abhd6 
                 0.08 
                 −0.14 
                 −0.31 
                 −1.03 
               
               
                   
                 Abhd8 
                 0 
                 0.37 
                 0.95 
                 1.06 
               
               
                   
                 Abhd9 
                 0 
                 1.7 
                 1.73 
                 0.48 
               
               
                   
                 Acaa1a /// Acaa1b 
                 −0.31 
                 −0.34 
                 −0.74 
                 −1.33 
               
               
                   
                 Acaa2 
                 0.72 
                 0.83 
                 −0.04 
                 −1.21 
               
               
                   
                 Acad11 
                 −0.38 
                 −0.45 
                 −0.86 
                 −1.56 
               
               
                   
                 Acadsb 
                 −1.73 
                 −1.8 
                 −1.48 
                 −1.3 
               
               
                   
                 Ace2 
                 −1.97 
                 −1.49 
                 −1.36 
                 −3.15 
               
               
                   
                 Acly 
                 −0.03 
                 −0.05 
                 −0.4 
                 −1.29 
               
               
                   
                 Acot1 /// Acot2 
                 −0.17 
                 0.26 
                 −0.28 
                 −1.24 
               
               
                   
                 Acot2 
                 −1.06 
                 −1.04 
                 −0.79 
                 −0.33 
               
               
                   
                 Acox1 
                 −0.57 
                 −0.62 
                 −0.75 
                 −1.45 
               
               
                   
                 Acpp 
                 −1.37 
                 −1.21 
                 −1.13 
                 −1.79 
               
               
                   
                 Acta2 
                 −2.4 
                 −1.3 
                 −1.46 
                 −0.39 
               
               
                   
                 Actg2 
                 −2.08 
                 −0.52 
                 −1.69 
                 −0.93 
               
               
                   
                 Actn1 
                 −0.01 
                 0.24 
                 0.38 
                 1.32 
               
               
                   
                 Ada 
                 0 
                 0.7 
                 1.36 
                 1.74 
               
               
                   
                 Adam10 
                 0.94 
                 1.37 
                 −0.34 
                 −1.77 
               
               
                   
                 Adam17 
                 0.26 
                 0.69 
                 0 
                 −1.8 
               
               
                   
                 Adam28 
                 −0.59 
                 −0.08 
                 −0.54 
                 −2.06 
               
               
                   
                 Adamdec1 
                 −1.73 
                 −1.19 
                 −1.1 
                 −1.68 
               
               
                   
                 Adar 
                 −0.13 
                 0 
                 −0.02 
                 −1.71 
               
               
                   
                 Adh7 
                 −0.34 
                 0 
                 0.38 
                 −1.52 
               
               
                   
                 Adi1 
                 −0.92 
                 −0.44 
                 −0.71 
                 −1.34 
               
               
                   
                 Adk 
                 −0.17 
                 0.2 
                 1.41 
                 1.69 
               
               
                   
                 Adm 
                 1.5 
                 0.72 
                 −0.29 
                 1.42 
               
               
                   
                 Adssl1 
                 −1.47 
                 −1.02 
                 −1.3 
                 −1.42 
               
               
                   
                 Aebp1 
                 −1.73 
                 −1.78 
                 −3.38 
                 0 
               
               
                   
                 Agpat1 
                 −0.34 
                 −0.1 
                 −1.25 
                 −1.47 
               
               
                   
                 Agps 
                 0.16 
                 0.38 
                 1.04 
                 1.25 
               
               
                   
                 Agtrl1 
                 0.07 
                 0.01 
                 0.62 
                 2.04 
               
               
                   
                 Ahcy 
                 0.89 
                 1.01 
                 0.84 
                 0.81 
               
               
                   
                 Ahcyl1 
                 0.72 
                 1.42 
                 −0.05 
                 −1.51 
               
               
                   
                 Ahnak 
                 −1 
                 −1.28 
                 −1.78 
                 −1.02 
               
               
                   
                 Ahr 
                 −0.47 
                 −0.56 
                 −0.58 
                 −1 
               
               
                   
                 Ak3 
                 0.06 
                 0.13 
                 −0.39 
                 −1.35 
               
               
                   
                 Ak3l1 
                 1.17 
                 0.92 
                 −0.56 
                 1.66 
               
               
                   
                 Akap10 
                 −0.12 
                 −0.02 
                 −0.3 
                 −2.6 
               
               
                   
                 Akap12 
                 −1.72 
                 −1.2 
                 −0.39 
                 0 
               
               
                   
                 Akp2 
                 −0.34 
                 −0.22 
                 −1.37 
                 −2.43 
               
               
                   
                 Akr1b8 
                 1.06 
                 0.85 
                 0.24 
                 0.35 
               
               
                   
                 Aldh1a7 
                 0.16 
                 0.14 
                 −0.8 
                 −1.21 
               
               
                   
                 Aldh1l1 
                 −1.06 
                 −1.39 
                 −1.58 
                 −1.93 
               
               
                   
                 Aldh2 
                 −1.37 
                 −1.12 
                 −1.06 
                 −0.09 
               
               
                   
                 Aldh3a1 
                 0 
                 −0.44 
                 0.5 
                 −1.49 
               
               
                   
                 Aldh6a1 
                 −0.74 
                 −0.82 
                 −1.23 
                 −1.75 
               
               
                   
                 Aldoc 
                 0.3 
                 0.62 
                 0.58 
                 1.12 
               
               
                   
                 Alg1 
                 −1.18 
                 −0.75 
                 −0.67 
                 −0.48 
               
               
                   
                 Alg6 
                 1.19 
                 1.22 
                 1.4 
                 0.47 
               
               
                   
                 Als2cr4 
                 0.21 
                 0.3 
                 1.02 
                 1.3 
               
               
                   
                 Amd1 /// Amd2 
                 0 
                 0.04 
                 −0.48 
                 −1.86 
               
               
                   
                 Ammecr1 
                 0.52 
                 0.79 
                 1.14 
                 1.25 
               
               
                   
                 Amn 
                 −1.79 
                 −1.94 
                 −1.24 
                 −1.25 
               
               
                   
                 Amot 
                 1.03 
                 1.26 
                 3.38 
                 3.43 
               
               
                   
                 Ampd2 
                 0.01 
                 0.4 
                 0.5 
                 1.45 
               
               
                   
                 Ang1 
                 −0.02 
                 0.5 
                 −0.66 
                 −1.47 
               
               
                   
                 Ang3 
                 0.25 
                 1.41 
                 2.52 
                 2.34 
               
               
                   
                 Ank 
                 0.71 
                 1.05 
                 0.38 
                 0.55 
               
               
                   
                 Ankrd22 
                 0.29 
                 0.32 
                 −0.34 
                 −1.11 
               
               
                   
                 Ankrd32 
                 0.88 
                 1.18 
                 1.29 
                 0.78 
               
               
                   
                 Ankrd35 
                 −0.74 
                 −0.71 
                 −1.06 
                 −1.51 
               
               
                   
                 Ankrd37 
                 2.69 
                 1.54 
                 1.15 
                 3.31 
               
               
                   
                 Ankrd43 
                 −0.08 
                 0.17 
                 −0.1 
                 −1.21 
               
               
                   
                 Ankrd46 
                 −0.55 
                 −0.24 
                 −0.5 
                 −1.09 
               
               
                   
                 Anln 
                 3.76 
                 2.5 
                 4.82 
                 2.27 
               
               
                   
                 Anp32b 
                 0.83 
                 0.4 
                 0.88 
                 1.26 
               
               
                   
                 Anp32e 
                 0.62 
                 0.73 
                 0.61 
                 1.08 
               
               
                   
                 Antxr1 
                 −1.53 
                 −1.63 
                 −1.4 
                 0.16 
               
               
                   
                 Anubl1 
                 1.62 
                 2.63 
                 1.21 
                 1.84 
               
               
                   
                 Anxa3 
                 1.66 
                 1.43 
                 1.41 
                 1.53 
               
               
                   
                 Anxa6 
                 −0.7 
                 −0.77 
                 −1.14 
                 −0.28 
               
               
                   
                 Anxa8 
                 0.81 
                 1.28 
                 0.22 
                 −0.46 
               
               
                   
                 Anxa9 
                 0.3 
                 0.11 
                 1.02 
                 0.72 
               
               
                   
                 Aof1 
                 −0.98 
                 −0.6 
                 −0.89 
                 −1.35 
               
               
                   
                 Aox1 
                 −2.14 
                 −1.98 
                 −2.5 
                 −2.52 
               
               
                   
                 Ap3b1 
                 0.49 
                 0.62 
                 −0.26 
                 −1.44 
               
               
                   
                 Ap3m1 
                 0.63 
                 0.85 
                 0.13 
                 −2 
               
               
                   
                 Ap3m1 /// 
                 0.31 
                 0.48 
                 0.09 
                 −1.16 
               
               
                   
                 LOC671800 
               
               
                   
                 Ap3m2 
                 −1.36 
                 −1.52 
                 −0.92 
                 −0.61 
               
               
                   
                 Apbb2 
                 −0.51 
                 −0.95 
                 −0.64 
                 −1.02 
               
               
                   
                 Apcdd1 
                 −0.97 
                 −0.89 
                 −1.32 
                 −1.52 
               
               
                   
                 Api5 
                 0.82 
                 1.22 
                 0.2 
                 −0.31 
               
               
                   
                 Aplp2 
                 −0.01 
                 −0.03 
                 −0.74 
                 −1.52 
               
               
                   
                 Apoc1 
                 −0.04 
                 0.02 
                 −0.61 
                 −1.19 
               
               
                   
                 App 
                 −0.32 
                 −0.3 
                 −0.81 
                 −1.41 
               
               
                   
                 Aqp1 
                 0.4 
                 −0.3 
                 0.31 
                 1.11 
               
               
                   
                 Aqp3 
                 0.21 
                 0.39 
                 −0.33 
                 −1.44 
               
               
                   
                 Araf 
                 −0.08 
                 0.4 
                 −0.47 
                 −1.27 
               
               
                   
                 Arcn1 
                 0.55 
                 1.04 
                 0.03 
                 −1.28 
               
               
                   
                 Areg 
                 2.19 
                 2.02 
                 0 
                 0 
               
               
                   
                 Arf1 
                 0.31 
                 0.51 
                 −0.22 
                 −1.03 
               
               
                   
                 Arf2 
                 0.62 
                 1.05 
                 0.28 
                 −0.9 
               
               
                   
                 Arfip2 
                 −1.04 
                 −1.19 
                 −1.05 
                 −1.18 
               
               
                   
                 Arhgap1 
                 0.23 
                 0.34 
                 −0.46 
                 −1.05 
               
               
                   
                 Arhgap11a 
                 3.2 
                 3.08 
                 3.31 
                 2.8 
               
               
                   
                 Arhgap26 
                 −1.46 
                 −1.63 
                 −1.21 
                 −1.43 
               
               
                   
                 Arl14 
                 0.54 
                 0.64 
                 1.62 
                 2.07 
               
               
                   
                 Arl2 
                 −0.38 
                 −0.82 
                 −0.97 
                 −1.01 
               
               
                   
                 Arl5b 
                 0.19 
                 0.91 
                 −0.06 
                 1.12 
               
               
                   
                 Arl6 
                 0.07 
                 0.56 
                 0.77 
                 1.16 
               
               
                   
                 Arl6ip2 
                 1.12 
                 1.2 
                 1.5 
                 1.47 
               
               
                   
                 Arl6ip6 /// 
                 0.62 
                 0.95 
                 0.67 
                 1.26 
               
               
                   
                 LOC674449 
               
               
                   
                 Armcx1 
                 −0.7 
                 −0.64 
                 −0.98 
                 −2 
               
               
                   
                 Armcx3 
                 −0.07 
                 −0.22 
                 −0.47 
                 −1.19 
               
               
                   
                 Arrb2 
                 0.69 
                 0.72 
                 1.01 
                 1.22 
               
               
                   
                 Arrdc3 
                 0.77 
                 0.92 
                 0.66 
                 1.17 
               
               
                   
                 Arsa 
                 −1.48 
                 −1.32 
                 −1.32 
                 −1.3 
               
               
                   
                 Asah2 
                 −0.9 
                 −1.05 
                 −1.07 
                 −1.1 
               
               
                   
                 Asah3l 
                 −0.97 
                 −0.98 
                 −0.78 
                 −1.22 
               
               
                   
                 Asb1 
                 −1.25 
                 −2.35 
                 −1.34 
                 −1.15 
               
               
                   
                 Asb8 
                 −0.06 
                 0.05 
                 −0.58 
                 −1.14 
               
               
                   
                 Ascc2 
                 −1.07 
                 −1.1 
                 −1.13 
                 −1.61 
               
               
                   
                 Asf1b 
                 2.79 
                 4.82 
                 2.82 
                 2.6 
               
               
                   
                 Aspm 
                 3.65 
                 2.84 
                 3.51 
                 2.34 
               
               
                   
                 Asrgl1 
                 0.41 
                 1.01 
                 1.34 
                 1.5 
               
               
                   
                 Ass1 
                 −0.51 
                 −0.57 
                 −1.23 
                 −1.33 
               
               
                   
                 Asxl1 
                 0.59 
                 0.76 
                 0.75 
                 1.59 
               
               
                   
                 Atad2 
                 2.26 
                 2.16 
                 2.32 
                 1.95 
               
               
                   
                 Atf3 
                 1.83 
                 2.57 
                 1.51 
                 1.81 
               
               
                   
                 Atf4 
                 0.36 
                 0.92 
                 0.57 
                 1.16 
               
               
                   
                 Atf5 
                 0.83 
                 0.48 
                 0.59 
                 1.1 
               
               
                   
                 Atp1b1 
                 0.98 
                 1.53 
                 1.44 
                 0.87 
               
               
                   
                 Atp2a2 
                 −0.44 
                 −0.04 
                 −0.56 
                 −1.32 
               
               
                   
                 Atp5s 
                 −0.5 
                 −0.29 
                 −0.56 
                 −1.16 
               
               
                   
                 Atp6v0a1 
                 −0.77 
                 −1.04 
                 −0.59 
                 −0.78 
               
               
                   
                 Atp6v1e1 
                 0.28 
                 −1.11 
                 0.43 
                 0.59 
               
               
                   
                 Atrn 
                 −0.65 
                 −0.6 
                 −1 
                 −1.49 
               
               
                   
                 Atrx 
                 −0.48 
                 0 
                 −0.5 
                 −1.59 
               
               
                   
                 Aurka 
                 2.34 
                 2.38 
                 2.48 
                 2.2 
               
               
                   
                 Aurkb 
                 3.04 
                 6.33 
                 2.78 
                 2.32 
               
               
                   
                 AV009015 
                 −0.71 
                 −0.74 
                 −0.93 
                 −1.33 
               
               
                   
                 Aytl2 
                 0.26 
                 0.2 
                 0.57 
                 1.04 
               
               
                   
                 B3galnt1 
                 1.12 
                 1.46 
                 1.23 
                 3.61 
               
               
                   
                 Bace1 
                 −0.85 
                 −0.93 
                 −0.78 
                 −1.22 
               
               
                   
                 Bace2 
                 −1.14 
                 −1.07 
                 −1.21 
                 −0.65 
               
               
                   
                 Baiap3 
                 −0.94 
                 −1.47 
                 −1.18 
                 −1.38 
               
               
                   
                 Bak1 
                 0.49 
                 0.11 
                 0.89 
                 1.24 
               
               
                   
                 Bat4 
                 0.13 
                 0.34 
                 1.07 
                 0.37 
               
               
                   
                 Baz1a 
                 0.9 
                 0.89 
                 1.09 
                 0.59 
               
               
                   
                 Baz1b 
                 0.97 
                 1.71 
                 0.52 
                 0 
               
               
                   
                 Baz2a 
                 −0.46 
                 −1.14 
                 −0.24 
                 0.32 
               
               
                   
                 Baz2b 
                 0.36 
                 0 
                 0.39 
                 −1.21 
               
               
                   
                 Bbox1 
                 0.54 
                 1.77 
                 0.72 
                 1.17 
               
               
                   
                 Bcam 
                 −0.65 
                 −1.01 
                 −1.42 
                 −1.73 
               
               
                   
                 Bcas1 
                 −2.81 
                 −2.4 
                 −1.62 
                 −1.73 
               
               
                   
                 Bcl10 
                 0.57 
                 1.11 
                 0.19 
                 −0.5 
               
               
                   
                 Bcl3 
                 0.53 
                 1.2 
                 −0.13 
                 1.6 
               
               
                   
                 Bcor 
                 0.23 
                 0.39 
                 0.47 
                 1 
               
               
                   
                 Bex1 
                 1.05 
                 1.22 
                 1.05 
                 2.57 
               
               
                   
                 Bex4 
                 −0.22 
                 −0.5 
                 −1.18 
                 −0.21 
               
               
                   
                 Bfar 
                 −0.57 
                 −0.98 
                 −0.32 
                 −1.17 
               
               
                   
                 Bglap-rs1 /// 
                 −1.17 
                 −0.73 
                 1.77 
                 0.69 
               
               
                   
                 Bglap1 /// Bglap2 
               
               
                   
                 Bgn 
                 −1.91 
                 −1.54 
                 −1.46 
                 −0.59 
               
               
                   
                 Bhlhb2 
                 0.38 
                 0.71 
                 0.24 
                 1.35 
               
               
                   
                 Bhmt2 
                 −2.24 
                 −4.75 
                 −3.01 
                 −3.95 
               
               
                   
                 Birc5 
                 4.44 
                 6.28 
                 4.38 
                 2.57 
               
               
                   
                 Blm 
                 1.95 
                 1.79 
                 1.46 
                 2.25 
               
               
                   
                 Bmp2 
                 −2.59 
                 −2.66 
                 −2.45 
                 −2.37 
               
               
                   
                 Bmp7 
                 −1.01 
                 −0.98 
                 −1.3 
                 −0.83 
               
               
                   
                 Bms1l 
                 0.08 
                 0.06 
                 0.61 
                 1.27 
               
               
                   
                 Bnip3 
                 1.52 
                 1.14 
                 −0.12 
                 1.57 
               
               
                   
                 Bok 
                 1.79 
                 1.72 
                 1.03 
                 2.18 
               
               
                   
                 Bphl 
                 −0.87 
                 −0.82 
                 −0.91 
                 −1.1 
               
               
                   
                 Braf 
                 −0.3 
                 −1.14 
                 −0.43 
                 −1.13 
               
               
                   
                 Brca1 
                 2.84 
                 4.19 
                 2.32 
                 0 
               
               
                   
                 Brca2 
                 1.27 
                 0.94 
                 1.64 
                 1.73 
               
               
                   
                 Bre 
                 0.15 
                 0.31 
                 −0.75 
                 −1.78 
               
               
                   
                 Brrn1 
                 1.77 
                 1.84 
                 1.82 
                 2.4 
               
               
                   
                 Brwd1 
                 −0.38 
                 −0.3 
                 −0.33 
                 −1.14 
               
               
                   
                 Bst2 
                 0.07 
                 0.38 
                 −0.19 
                 1.43 
               
               
                   
                 Btbd11 
                 0.07 
                 −0.27 
                 −0.77 
                 −1.33 
               
               
                   
                 Bub1 
                 5.07 
                 3.52 
                 3.76 
                 3.16 
               
               
                   
                 Bub1b 
                 5.38 
                 3.54 
                 5.44 
                 2.81 
               
               
                   
                 Bxdc5 
                 0.49 
                 1.18 
                 0.23 
                 −0.37 
               
               
                   
                 Bzw1 
                 1.25 
                 1.31 
                 0.51 
                 −0.91 
               
               
                   
                 C1galt1 
                 0.48 
                 1.17 
                 −0.49 
                 −1.67 
               
               
                   
                 Cabc1 
                 −0.82 
                 −1 
                 −1.08 
                 −1.62 
               
               
                   
                 Cacna1h 
                 −2.74 
                 −2.49 
                 −1.74 
                 −1.85 
               
               
                   
                 Cald1 
                 −2.5 
                 −1.35 
                 −1.28 
                 0.67 
               
               
                   
                 Calml3 
                 0 
                 0 
                 4.33 
                 0 
               
               
                   
                 Camk2b 
                 0 
                 0.03 
                 1.38 
                 2.66 
               
               
                   
                 Camk2d 
                 −1.48 
                 −1.77 
                 −0.84 
                 −0.94 
               
               
                   
                 Camk2n1 
                 −1.48 
                 −1.27 
                 −0.82 
                 −0.34 
               
               
                   
                 Cap1 
                 0.46 
                 0.91 
                 0.24 
                 −1.06 
               
               
                   
                 Capn1 
                 −0.07 
                 −0.06 
                 −0.86 
                 −1.37 
               
               
                   
                 Capn2 
                 0.84 
                 0.65 
                 0.71 
                 1.27 
               
               
                   
                 Car13 
                 1.2 
                 1.14 
                 1.1 
                 0.91 
               
               
                   
                 Car2 
                 0.08 
                 0.73 
                 1.18 
                 1.23 
               
               
                   
                 Car3 
                 −2.66 
                 −2.75 
                 −2.06 
                 −3.43 
               
               
                   
                 Car8 /// 
                 −2.62 
                 0 
                 −2.42 
                 −1.79 
               
               
                   
                 LOC676792 
               
               
                   
                 Car9 
                 0 
                 0 
                 0 
                 2.22 
               
               
                   
                 Card14 
                 −0.75 
                 −1.02 
                 −0.84 
                 −1.42 
               
               
                   
                 Carhsp1 
                 1.85 
                 1.52 
                 0.66 
                 0.65 
               
               
                   
                 Casc4 
                 −1.19 
                 −1.23 
                 −0.88 
                 0.07 
               
               
                   
                 Cask 
                 0.55 
                 1.2 
                 0.14 
                 −1.99 
               
               
                   
                 Casp2 
                 0.95 
                 1.22 
                 0.86 
                 0.64 
               
               
                   
                 Casp3 
                 1.34 
                 1.06 
                 0.59 
                 0 
               
               
                   
                 Casp7 
                 0.98 
                 1.39 
                 0.88 
                 −0.06 
               
               
                   
                 Casp8ap2 
                 0.86 
                 1.35 
                 1.2 
                 1.53 
               
               
                   
                 Cat 
                 −0.62 
                 −0.32 
                 −0.78 
                 −1.35 
               
               
                   
                 Cav1 
                 −1.27 
                 −0.71 
                 −1.81 
                 −0.33 
               
               
                   
                 Cbr2 
                 −0.59 
                 −0.33 
                 −0.8 
                 −1.62 
               
               
                   
                 Cbx2 
                 0.71 
                 0.73 
                 0.8 
                 1.63 
               
               
                   
                 Cbx5 
                 1.09 
                 1.75 
                 1.29 
                 0.9 
               
               
                   
                 Ccbl1 
                 −0.32 
                 −0.52 
                 −0.71 
                 −1.35 
               
               
                   
                 Ccdc28b 
                 0.05 
                 0.37 
                 0.8 
                 1.07 
               
               
                   
                 Ccdc39 
                 0.11 
                 −0.99 
                 −0.15 
                 −1.6 
               
               
                   
                 Ccdc39 /// Ttc14 
                 −0.08 
                 −1.03 
                 0.47 
                 −1.78 
               
               
                   
                 Ccdc5 
                 1.42 
                 1.29 
                 1.38 
                 1.34 
               
               
                   
                 Ccdc69 
                 −0.8 
                 −0.57 
                 −0.8 
                 −1.49 
               
               
                   
                 Ccdc80 
                 −1.48 
                 −0.88 
                 −1.27 
                 −0.78 
               
               
                   
                 Ccdc99 
                 2 
                 1.68 
                 1.82 
                 1.84 
               
               
                   
                 Cchcr1 
                 0.71 
                 0.76 
                 1.08 
                 1.19 
               
               
                   
                 Ccna2 
                 4.56 
                 3.36 
                 4.72 
                 2.72 
               
               
                   
                 Ccnb1 
                 5.84 
                 3.32 
                 5.67 
                 1.98 
               
               
                   
                 Ccnb2 
                 4 
                 3.17 
                 4.72 
                 2.18 
               
               
                   
                 Ccnd1 
                 −1.92 
                 −2.66 
                 −1.38 
                 −1.68 
               
               
                   
                 Ccnd2 
                 −4.45 
                 −4.1 
                 −2.45 
                 −2.86 
               
               
                   
                 Ccne1 
                 2.46 
                 2.2 
                 2.73 
                 3.39 
               
               
                   
                 Ccne2 
                 3.33 
                 4.58 
                 2.65 
                 3.9 
               
               
                   
                 Ccnf 
                 3.26 
                 2.66 
                 2.89 
                 2.4 
               
               
                   
                 Ccng1 
                 −0.12 
                 0.07 
                 −1.04 
                 −1.09 
               
               
                   
                 Ccng2 
                 0.88 
                 1.34 
                 0.02 
                 −0.48 
               
               
                   
                 Ccnjl 
                 −0.44 
                 −0.59 
                 −0.97 
                 −1.11 
               
               
                   
                 Ccnl2 
                 0.17 
                 0.56 
                 0.09 
                 −1.18 
               
               
                   
                 Ccnt2 
                 0.06 
                 −0.63 
                 −0.06 
                 −2.33 
               
               
                   
                 Ccpg1 
                 −1.59 
                 −1.68 
                 −0.55 
                 −1.03 
               
               
                   
                 Ccrn4l 
                 1.46 
                 1.48 
                 0.77 
                 1.32 
               
               
                   
                 Cd200r3 
                 −0.97 
                 0 
                 0 
                 −2.88 
               
               
                   
                 Cd44 
                 1.39 
                 2.08 
                 0.01 
                 −0.35 
               
               
                   
                 Cd55 
                 0.13 
                 0.32 
                 −0.59 
                 −1.07 
               
               
                   
                 Cd59a 
                 −1.01 
                 −1.63 
                 −1.73 
                 −2.71 
               
               
                   
                 Cd99l2 
                 −0.14 
                 −0.24 
                 −0.49 
                 −1.09 
               
               
                   
                 Cdadc1 
                 −0.75 
                 −0.93 
                 −0.39 
                 −1.34 
               
               
                   
                 Cdc20 
                 2.97 
                 3 
                 3.65 
                 2.36 
               
               
                   
                 Cdc23 
                 0.28 
                 0.71 
                 −0.14 
                 −1.06 
               
               
                   
                 Cdc25b 
                 1.28 
                 1.94 
                 1.97 
                 1.91 
               
               
                   
                 Cdc2a 
                 4.39 
                 3.54 
                 4.63 
                 2.83 
               
               
                   
                 Cdc37l1 
                 −0.19 
                 −0.78 
                 −0.25 
                 −1.62 
               
               
                   
                 Cdc42ep2 
                 −1.17 
                 −1.04 
                 −0.87 
                 −1.84 
               
               
                   
                 Cdc42ep3 
                 −0.52 
                 −0.37 
                 −1.09 
                 −0.84 
               
               
                   
                 Cdc45l 
                 2.9 
                 4.44 
                 2.67 
                 2.06 
               
               
                   
                 Cdc6 
                 2.81 
                 3.1 
                 2.38 
                 2.6 
               
               
                   
                 Cdc7 
                 4.58 
                 5.04 
                 3.26 
                 1.76 
               
               
                   
                 Cdc73 
                 −0.59 
                 −1.09 
                 −0.6 
                 −0.72 
               
               
                   
                 Cdca1 
                 4.75 
                 4.26 
                 4.07 
                 1.65 
               
               
                   
                 Cdca3 
                 3.02 
                 2.74 
                 3.24 
                 2.48 
               
               
                   
                 Cdca4 
                 1.08 
                 1.08 
                 0.76 
                 1.26 
               
               
                   
                 Cdca5 
                 2.5 
                 3.1 
                 4.3 
                 2.05 
               
               
                   
                 Cdca7 
                 1.1 
                 1.6 
                 0.89 
                 1.37 
               
               
                   
                 Cdca7l 
                 0.95 
                 0.69 
                 1.06 
                 1.05 
               
               
                   
                 Cdca8 
                 2.43 
                 2.64 
                 3.72 
                 2.75 
               
               
                   
                 Cdk2 
                 1.73 
                 1.68 
                 1.73 
                 1.29 
               
               
                   
                 Cdk5rap2 
                 0.78 
                 1.12 
                 2.07 
                 0.83 
               
               
                   
                 Cdk6 
                 −1.37 
                 −1.27 
                 −0.24 
                 −0.98 
               
               
                   
                 Cdkn1a 
                 0.74 
                 1.13 
                 1.81 
                 2.24 
               
               
                   
                 Cdkn1b 
                 0.39 
                 0.54 
                 0.81 
                 1.13 
               
               
                   
                 Cdkn1c 
                 1.07 
                 0.18 
                 0 
                 1.94 
               
               
                   
                 Cdkn2a 
                 0 
                 4.03 
                 2.97 
                 2.58 
               
               
                   
                 Cdkn2c 
                 2.05 
                 2.2 
                 2.9 
                 2.5 
               
               
                   
                 Cdkn2d 
                 1.01 
                 1.59 
                 1.45 
                 1.27 
               
               
                   
                 Cdkn3 
                 2.58 
                 2.49 
                 2.54 
                 2.36 
               
               
                   
                 Cdo1 
                 1 
                 0.54 
                 0.85 
                 1.03 
               
               
                   
                 Cdt1 
                 2.27 
                 2.41 
                 1.77 
                 2.76 
               
               
                   
                 Ceacam1 
                 0 
                 0 
                 1.42 
                 2.61 
               
               
                   
                 Ceacam1 /// 
                 −1.07 
                 −0.23 
                 1.5 
                 1.46 
               
               
                   
                 Ceacam2 
               
               
                   
                 Cenpa 
                 3.58 
                 2.98 
                 3.33 
                 2.59 
               
               
                   
                 Cenpe 
                 3.25 
                 2.39 
                 3.51 
                 2.3 
               
               
                   
                 Cenpf 
                 5.21 
                 2.45 
                 5.8 
                 2.29 
               
               
                   
                 Cenph 
                 2.89 
                 3.13 
                 3.34 
                 1.95 
               
               
                   
                 Cenpj 
                 1.26 
                 1.42 
                 1.58 
                 1.53 
               
               
                   
                 Centg2 
                 0.27 
                 0.61 
                 1.17 
                 1.93 
               
               
                   
                 Cep55 
                 3.81 
                 3.67 
                 3.51 
                 2.54 
               
               
                   
                 Cept1 
                 0.67 
                 0 
                 0.05 
                 −2.06 
               
               
                   
                 Cfd 
                 0 
                 0 
                 −4 
                 0 
               
               
                   
                 Cggbp1 
                 1.05 
                 0.76 
                 0.3 
                 0.75 
               
               
                   
                 Cgnl1 /// 
                 −1.02 
                 −1.65 
                 −0.41 
                 −0.62 
               
               
                   
                 LOC677485 
               
               
                   
                 Chac1 
                 0.61 
                 0.95 
                 0.45 
                 1.35 
               
               
                   
                 Chaf1b 
                 2.46 
                 2.93 
                 2.26 
                 2.01 
               
               
                   
                 Chek1 
                 2.63 
                 5.52 
                 2.89 
                 2.67 
               
               
                   
                 Chek2 
                 0.78 
                 1.15 
                 1.18 
                 0.75 
               
               
                   
                 Chka 
                 0.91 
                 0.81 
                 1.09 
                 1.1 
               
               
                   
                 Chst2 
                 −1.33 
                 −2.16 
                 −1.15 
                 −1.51 
               
               
                   
                 Chtf18 
                 2.29 
                 1.68 
                 2.51 
                 1.86 
               
               
                   
                 Chuk 
                 0.36 
                 0.61 
                 −0.05 
                 −1.25 
               
               
                   
                 Cirbp 
                 −0.43 
                 −0.67 
                 −0.94 
                 −1.02 
               
               
                   
                 Cited2 
                 1.06 
                 0.01 
                 −0.2 
                 0.86 
               
               
                   
                 Ckap2 
                 2.97 
                 2.66 
                 3.06 
                 2.05 
               
               
                   
                 Ckap2l 
                 2.87 
                 4.69 
                 2.31 
                 1.47 
               
               
                   
                 Ckap4 
                 0.48 
                 0.16 
                 0.52 
                 1.08 
               
               
                   
                 Ckap5 
                 0.9 
                 1.25 
                 0.82 
                 0.23 
               
               
                   
                 Ckb 
                 −2.2 
                 −0.95 
                 −1.13 
                 0 
               
               
                   
                 Cklf 
                 0.42 
                 0.31 
                 0.72 
                 1.46 
               
               
                   
                 Ckmt1 
                 0.58 
                 0.61 
                 −0.41 
                 −1.85 
               
               
                   
                 Cks1b 
                 1.67 
                 1.48 
                 2.05 
                 1.95 
               
               
                   
                 Cks2 
                 1.69 
                 1.45 
                 1.7 
                 1.86 
               
               
                   
                 Clca1 
                 −1.57 
                 −1.14 
                 −1.36 
                 −0.87 
               
               
                   
                 Clca1 /// Clca2 
                 −0.94 
                 −0.71 
                 −0.98 
                 −1.93 
               
               
                   
                 Clca2 
                 −1 
                 −0.7 
                 −0.98 
                 −1.32 
               
               
                   
                 Clcn5 
                 −0.49 
                 −1.11 
                 −0.83 
                 −0.19 
               
               
                   
                 Cldn1 
                 1.25 
                 2.56 
                 0.84 
                 0.85 
               
               
                   
                 Cldn3 
                 2.58 
                 4.09 
                 5.52 
                 3.76 
               
               
                   
                 Cldn8 
                 −0.92 
                 −1.03 
                 −0.92 
                 −1.48 
               
               
                   
                 Clic4 
                 −0.2 
                 0.41 
                 0.53 
                 1.05 
               
               
                   
                 Clock /// 
                 −0.18 
                 −0.44 
                 −0.1 
                 −1.23 
               
               
                   
                 LOC620729 
               
               
                   
                 Clspn 
                 3.14 
                 2.91 
                 4.04 
                 3.21 
               
               
                   
                 Cltc 
                 0.19 
                 0 
                 −0.42 
                 −1.62 
               
               
                   
                 Clu 
                 −0.62 
                 −1.12 
                 −0.77 
                 −0.28 
               
               
                   
                 Clybl 
                 −0.75 
                 0.12 
                 −0.66 
                 −1.03 
               
               
                   
                 Cmkor1 
                 −0.13 
                 −1.43 
                 −0.91 
                 −0.5 
               
               
                   
                 Cnn1 
                 −3.52 
                 0 
                 −2.06 
                 0 
               
               
                   
                 Cnn2 
                 0.1 
                 −0.21 
                 0.34 
                 1.37 
               
               
                   
                 Cnnm2 
                 −1.19 
                 −1.23 
                 −0.68 
                 −0.93 
               
               
                   
                 Cnnm4 
                 0.28 
                 0.54 
                 0.1 
                 −1.4 
               
               
                   
                 Cntf /// Zfp91 
                 0.56 
                 0.48 
                 0.68 
                 1.26 
               
               
                   
                 Cntnap2 
                 −1.19 
                 −1.16 
                 −1.68 
                 −1.34 
               
               
                   
                 Col18a1 
                 −0.44 
                 −0.46 
                 −1.28 
                 −0.87 
               
               
                   
                 Col1a1 
                 −3.51 
                 −2.26 
                 −1.5 
                 −2.81 
               
               
                   
                 Col1a2 
                 −3.82 
                 −2.29 
                 −1.63 
                 −1.35 
               
               
                   
                 Col3a1 
                 −2.25 
                 −1.87 
                 −1.66 
                 −1.7 
               
               
                   
                 Col4a1 
                 0.01 
                 0.45 
                 −0.01 
                 2.37 
               
               
                   
                 Col5a1 
                 −2.24 
                 −1.14 
                 −0.61 
                 0 
               
               
                   
                 Col5a2 
                 −2.84 
                 −1.55 
                 −1.71 
                 0 
               
               
                   
                 Col6a1 
                 −2.7 
                 −1.85 
                 −1.11 
                 −1.04 
               
               
                   
                 Col6a2 
                 −2.96 
                 −1.93 
                 −1.66 
                 0 
               
               
                   
                 Col6a3 /// 
                 −1.96 
                 −1.37 
                 −0.4 
                 −0.1 
               
               
                   
                 LOC674521 
               
               
                   
                 Copg2 
                 −0.36 
                 −0.47 
                 −0.61 
                 −1.07 
               
               
                   
                 Copz2 
                 −1.43 
                 −1.13 
                 −1.64 
                 −1.62 
               
               
                   
                 Coq5 
                 −0.04 
                 0.22 
                 −0.36 
                 −1.04 
               
               
                   
                 Coro1c 
                 0.64 
                 1.34 
                 −0.42 
                 −0.99 
               
               
                   
                 Coro2a 
                 0.65 
                 1.41 
                 0.9 
                 1.46 
               
               
                   
                 Cotl1 
                 −0.41 
                 −1 
                 −0.65 
                 0.18 
               
               
                   
                 Cpd 
                 0.87 
                 0.96 
                 0.01 
                 −1.68 
               
               
                   
                 Cpeb2 
                 0.98 
                 1.29 
                 0.45 
                 −0.75 
               
               
                   
                 Cpsf2 
                 0.64 
                 1.29 
                 0.8 
                 −0.28 
               
               
                   
                 Cpsf3l 
                 0.82 
                 0.71 
                 1.23 
                 0.8 
               
               
                   
                 Crabp2 
                 0.39 
                 −1.02 
                 −1.72 
                 −1.23 
               
               
                   
                 Creb3l2 
                 −1.14 
                 −1.37 
                 −1.33 
                 −1.3 
               
               
                   
                 Crebl2 
                 −1.21 
                 −1.05 
                 −0.93 
                 −0.84 
               
               
                   
                 Creld1 
                 −0.6 
                 −0.56 
                 −0.98 
                 −1.17 
               
               
                   
                 Cri1 
                 −0.33 
                 −0.18 
                 −0.21 
                 1.01 
               
               
                   
                 Crim1 
                 −0.56 
                 −1.4 
                 −1.04 
                 −1.03 
               
               
                   
                 Crip1 
                 0.51 
                 0.79 
                 0.45 
                 1.71 
               
               
                   
                 Crispld2 
                 −3.85 
                 −2.68 
                 −2.65 
                 0 
               
               
                   
                 Crot 
                 −0.2 
                 −0.14 
                 −0.42 
                 −1.01 
               
               
                   
                 Cry1 
                 0.39 
                 0.93 
                 0.7 
                 1.1 
               
               
                   
                 Cryz 
                 −0.84 
                 −1.15 
                 −0.88 
                 −0.34 
               
               
                   
                 Cryzl1 
                 0.07 
                 0.45 
                 −0.49 
                 −1.25 
               
               
                   
                 Csad 
                 −0.86 
                 −0.76 
                 −1.08 
                 −0.96 
               
               
                   
                 Csf1r 
                 −1.18 
                 −0.92 
                 −0.28 
                 1 
               
               
                   
                 Csnk1a1 
                 0.05 
                 −0.77 
                 −0.2 
                 −1.74 
               
               
                   
                 Csnk1e 
                 −0.06 
                 0.25 
                 0.3 
                 1 
               
               
                   
                 Cspg5 
                 −1.66 
                 −1.13 
                 −1.37 
                 −2.1 
               
               
                   
                 Csprs /// 
                 0 
                 0 
                 2.04 
                 3.11 
               
               
                   
                 LOC665338 
               
               
                   
                 Csrp1 
                 0.27 
                 1.08 
                 0.63 
                 0.82 
               
               
                   
                 Cstf2 
                 1.09 
                 1.23 
                 1.22 
                 0.39 
               
               
                   
                 Ctf1 
                 −0.6 
                 −0.71 
                 −0.61 
                 −1.11 
               
               
                   
                 Ctla2a 
                 0.6 
                 −0.33 
                 0 
                 1.73 
               
               
                   
                 Ctnnal1 
                 −0.15 
                 −0.28 
                 −1.39 
                 −2.27 
               
               
                   
                 Ctnnb1 
                 0.84 
                 1.26 
                 −0.03 
                 −1.98 
               
               
                   
                 Ctnnd2 
                 −1.06 
                 −0.85 
                 −1.72 
                 −1.3 
               
               
                   
                 Ctns 
                 −1.2 
                 −1.6 
                 −1.04 
                 −1.69 
               
               
                   
                 Ctsd 
                 −0.68 
                 −0.98 
                 −1.1 
                 −1.05 
               
               
                   
                 Ctse 
                 2.69 
                 2.5 
                 1.87 
                 0 
               
               
                   
                 Ctss 
                 −0.49 
                 0.94 
                 0.72 
                 1.59 
               
               
                   
                 Cttn 
                 −0.02 
                 0.53 
                 −0.38 
                 −1.7 
               
               
                   
                 Cxadr 
                 1.52 
                 1.15 
                 1.54 
                 0.34 
               
               
                   
                 Cxcl10 
                 3.99 
                 2.97 
                 0 
                 3.34 
               
               
                   
                 Cxcl14 
                 −3.03 
                 −1.82 
                 −1.12 
                 −1.38 
               
               
                   
                 Cxcl16 
                 0.97 
                 1.42 
                 1 
                 0.85 
               
               
                   
                 Cxx1b 
                 −0.37 
                 −0.8 
                 −1.05 
                 −1.07 
               
               
                   
                 Cyb5b 
                 −0.23 
                 0 
                 −0.94 
                 −1.47 
               
               
                   
                 Cyb5r3 
                 0.03 
                 0.08 
                 −0.94 
                 −3.06 
               
               
                   
                 Cyba 
                 −0.26 
                 0.29 
                 0.49 
                 1.5 
               
               
                   
                 Cyfip2 
                 −1 
                 −1.1 
                 −1.04 
                 −1.76 
               
               
                   
                 Cyhr1 
                 −1.17 
                 −1.08 
                 −0.83 
                 −1.12 
               
               
                   
                 Cyp1a1 
                 −2.52 
                 −2.16 
                 −1.12 
                 −3.01 
               
               
                   
                 Cyp1b1 
                 −1.39 
                 −1.05 
                 −0.36 
                 −1.96 
               
               
                   
                 Cyp27a1 
                 −0.19 
                 −0.04 
                 0.38 
                 −1.56 
               
               
                   
                 Cyp2f2 
                 −2.71 
                 −0.25 
                 −0.82 
                 −1.75 
               
               
                   
                 Cyp4f15 
                 −2.27 
                 −2.13 
                 −2.01 
                 −3.15 
               
               
                   
                 Cyp4v3 
                 −1.23 
                 −0.95 
                 −0.7 
                 −0.44 
               
               
                   
                 Dab1 
                 −1.48 
                 −0.47 
                 −0.42 
                 −1.63 
               
               
                   
                 Dab2 
                 −1.58 
                 −1.76 
                 −2.62 
                 −1.89 
               
               
                   
                 Dalrd3 
                 −0.32 
                 −0.21 
                 −0.66 
                 −1.08 
               
               
                   
                 Dapk1 
                 −0.23 
                 −0.44 
                 −1.14 
                 −1.43 
               
               
                   
                 Dapp1 
                 −1.57 
                 −1.43 
                 −0.37 
                 −0.68 
               
               
                   
                 Dbf4 
                 1.79 
                 1.69 
                 2.05 
                 1.77 
               
               
                   
                 Dbp 
                 −1.63 
                 −2.04 
                 −1.36 
                 −1.36 
               
               
                   
                 Dcbld2 
                 0.86 
                 0.72 
                 1.59 
                 0.99 
               
               
                   
                 Dck 
                 1.77 
                 2.08 
                 2.39 
                 2.48 
               
               
                   
                 Dcn 
                 −1.96 
                 −1.92 
                 −1.87 
                 −1.87 
               
               
                   
                 Dctd 
                 0.65 
                 1.19 
                 0.46 
                 0.24 
               
               
                   
                 Dcun1d1 
                 0.65 
                 1.09 
                 0.11 
                 −0.62 
               
               
                   
                 Dcxr 
                 −0.77 
                 −0.5 
                 −1.11 
                 −0.81 
               
               
                   
                 Ddx11 
                 1.13 
                 3.59 
                 1.05 
                 0.93 
               
               
                   
                 Ddx20 
                 1.02 
                 0.62 
                 0.8 
                 0.45 
               
               
                   
                 Ddx39 
                 1.24 
                 1.11 
                 1.18 
                 1.8 
               
               
                   
                 Ddx3y 
                 −4.12 
                 −0.44 
                 0 
                 3.54 
               
               
                   
                 Ddx46 
                 1.21 
                 1.29 
                 0.54 
                 −0.77 
               
               
                   
                 Decr1 
                 −0.75 
                 −0.62 
                 −0.52 
                 −1.16 
               
               
                   
                 Decr2 
                 −0.71 
                 −0.32 
                 −0.77 
                 −1.31 
               
               
                   
                 Defb1 
                 −2.27 
                 −2.49 
                 −2.12 
                 −3.18 
               
               
                   
                 Degs1 
                 −1.08 
                 −0.17 
                 0.56 
                 1.7 
               
               
                   
                 Dek 
                 0.84 
                 1.01 
                 1.03 
                 1.04 
               
               
                   
                 Dennd2d 
                 −0.37 
                 −0.71 
                 −0.77 
                 −1.05 
               
               
                   
                 Depdc1a 
                 3.33 
                 2.94 
                 2.97 
                 1.95 
               
               
                   
                 Depdc6 
                 −1.13 
                 −0.89 
                 −0.65 
                 −2.12 
               
               
                   
                 Dfna5h 
                 −0.03 
                 0.37 
                 −0.82 
                 −1.45 
               
               
                   
                 Dgcr6 
                 −1.42 
                 −1.59 
                 −1.13 
                 −0.98 
               
               
                   
                 Dgkd 
                 0.08 
                 0.33 
                 0.36 
                 1.17 
               
               
                   
                 Dhfr 
                 2.09 
                 2.37 
                 2.09 
                 2.15 
               
               
                   
                 Dhrs3 
                 −0.96 
                 −0.9 
                 −0.54 
                 −1.08 
               
               
                   
                 Diap1 
                 −0.25 
                 0 
                 −0.04 
                 −1.76 
               
               
                   
                 Diap3 
                 3.8 
                 2.34 
                 4.13 
                 2.57 
               
               
                   
                 Dlc1 
                 −0.7 
                 −0.73 
                 −0.49 
                 −1.03 
               
               
                   
                 Dleu8 
                 1.1 
                 0.73 
                 1.22 
                 1.09 
               
               
                   
                 Dlg7 
                 2.62 
                 2.68 
                 2.47 
                 1.96 
               
               
                   
                 Dmgdh 
                 −2.23 
                 −2.77 
                 −4.15 
                 −4.42 
               
               
                   
                 Dmn 
                 −3.14 
                 0 
                 −1.04 
                 0 
               
               
                   
                 Dna2l 
                 2 
                 2.22 
                 2.6 
                 2.15 
               
               
                   
                 Dnaja2 
                 −0.1 
                 −0.75 
                 −0.29 
                 −1.43 
               
               
                   
                 Dnaja3 
                 0.58 
                 0.64 
                 0.06 
                 −1.3 
               
               
                   
                 Dnaja4 
                 0.02 
                 0.36 
                 −0.56 
                 −1.14 
               
               
                   
                 Dnajb1 
                 0.63 
                 1.09 
                 −0.06 
                 0 
               
               
                   
                 Dnajb14 
                 −0.94 
                 −1.07 
                 −0.6 
                 0.51 
               
               
                   
                 Dnajc1 
                 0.5 
                 0 
                 −0.15 
                 −2.07 
               
               
                   
                 Dnajc12 
                 −0.53 
                 −0.55 
                 −0.2 
                 −1.06 
               
               
                   
                 Dnajc3 
                 −0.14 
                 0 
                 −0.25 
                 −1.02 
               
               
                   
                 Dnajc5 
                 1 
                 0.73 
                 0.12 
                 0.21 
               
               
                   
                 Dnajc6 
                 −1.32 
                 −1.71 
                 0.1 
                 −0.49 
               
               
                   
                 Dnajc9 
                 1.57 
                 1.68 
                 1.82 
                 1.41 
               
               
                   
                 Dnm1l 
                 0.35 
                 0.49 
                 −0.32 
                 −1.07 
               
               
                   
                 Dnm2 
                 0.47 
                 0.65 
                 −0.4 
                 −2.08 
               
               
                   
                 Dnmt1 
                 1.37 
                 1.33 
                 1.8 
                 2.06 
               
               
                   
                 Dnmt3l 
                 −0.31 
                 −0.48 
                 −1.02 
                 −1.57 
               
               
                   
                 Dock11 
                 1.05 
                 2.22 
                 2.72 
                 2.96 
               
               
                   
                 Dock8 
                 −0.68 
                 −0.63 
                 −0.81 
                 −1.04 
               
               
                   
                 Dock9 /// 
                 −0.51 
                 −0.63 
                 −0.79 
                 −1.56 
               
               
                   
                 LOC670309 
               
               
                   
                 Donson 
                 1.53 
                 1.09 
                 1.65 
                 1.65 
               
               
                   
                 Dpt 
                 −2.47 
                 −1.52 
                 −1.26 
                 0 
               
               
                   
                 Dpysl2 
                 1.03 
                 1.56 
                 2.25 
                 2.84 
               
               
                   
                 Dr1 
                 0.68 
                 1.12 
                 −0.07 
                 −0.68 
               
               
                   
                 Dsc2 
                 0.14 
                 1.41 
                 0.66 
                 −0.81 
               
               
                   
                 Dscr1 
                 −0.21 
                 0.69 
                 −1.34 
                 −2.79 
               
               
                   
                 Dsg2 
                 −0.19 
                 −0.5 
                 −0.57 
                 −1.13 
               
               
                   
                 Dsp 
                 1.24 
                 1.53 
                 0.45 
                 −1.72 
               
               
                   
                 Dst 
                 −0.91 
                 −1.52 
                 −0.48 
                 −0.84 
               
               
                   
                 Dtl 
                 4.38 
                 3.86 
                 2.84 
                 3.29 
               
               
                   
                 Dtnb 
                 0.38 
                 1.4 
                 0.53 
                 0.13 
               
               
                   
                 Dusp1 
                 1.17 
                 0.95 
                 0.66 
                 1.55 
               
               
                   
                 Dusp16 
                 −0.02 
                 0 
                 −0.28 
                 −1.56 
               
               
                   
                 Dusp9 
                 1.2 
                 1.01 
                 −0.17 
                 0.35 
               
               
                   
                 Dut 
                 1.6 
                 2.02 
                 1.86 
                 2.03 
               
               
                   
                 Dvl1 
                 −0.18 
                 −0.16 
                 0.58 
                 1.27 
               
               
                   
                 Dynll1 /// 
                 0.33 
                 0.42 
                 0.8 
                 1.09 
               
               
                   
                 LOC627788 /// 
               
               
                   
                 LOC637840 /// 
               
               
                   
                 LOC672375 
               
               
                   
                 Dynlt1 /// 
                 1.04 
                 1 
                 0.88 
                 0.45 
               
               
                   
                 LOC671261 
               
               
                   
                 Dynlt3 
                 0.14 
                 0.37 
                 −0.87 
                 −1.88 
               
               
                   
                 Dyrk1a 
                 0.8 
                 1.18 
                 0.22 
                 −1.08 
               
               
                   
                 Dysf /// Fer1l3 
                 −0.63 
                 −0.56 
                 −0.54 
                 −1.42 
               
               
                   
                 E2f1 
                 1.58 
                 3.19 
                 2.41 
                 3.4 
               
               
                   
                 E2f7 
                 3.54 
                 2.27 
                 3.33 
                 2.69 
               
               
                   
                 E2f8 
                 5.17 
                 3.29 
                 3.27 
                 3.98 
               
               
                   
                 Ecgf1 
                 −0.56 
                 −0.69 
                 −1 
                 −1.05 
               
               
                   
                 Ecm1 
                 −1.44 
                 −1.03 
                 −0.99 
                 −0.56 
               
               
                   
                 Ect2 
                 2.59 
                 2.37 
                 2.88 
                 2.25 
               
               
                   
                 Edg7 
                 −2.37 
                 −1.03 
                 −1.38 
                 −4.22 
               
               
                   
                 Efemp1 
                 −1.85 
                 −1.82 
                 −1.61 
                 −0.84 
               
               
                   
                 Egfl6 
                 −1.27 
                 −0.73 
                 −2.92 
                 −2.46 
               
               
                   
                 Egln3 
                 1.62 
                 1.4 
                 −0.23 
                 0.94 
               
               
                   
                 Egr1 
                 1.04 
                 3.02 
                 2.18 
                 2.66 
               
               
                   
                 Ehf 
                 0.24 
                 0.33 
                 −0.16 
                 −1.27 
               
               
                   
                 Eif2ak1 
                 0.1 
                 −0.04 
                 0 
                 −1.33 
               
               
                   
                 Eif2ak2 
                 0.73 
                 1.02 
                 0.71 
                 −0.64 
               
               
                   
                 Eif2s3x /// 
                 1.01 
                 1.24 
                 0.03 
                 −0.86 
               
               
                   
                 LOC673373 
               
               
                   
                 Eif2s3y 
                 −4.02 
                 −0.69 
                 0 
                 3.71 
               
               
                   
                 Eif4a1 
                 0.66 
                 1.02 
                 0.08 
                 −1.03 
               
               
                   
                 Eif4a2 
                 −0.62 
                 −0.44 
                 −0.81 
                 −1.16 
               
               
                   
                 Eif4ebp2 
                 0.36 
                 0.46 
                 −0.47 
                 −1.64 
               
               
                   
                 Eif4g1 
                 0.28 
                 1.13 
                 −0.59 
                 −0.5 
               
               
                   
                 Eif5 
                 −0.25 
                 −0.61 
                 −0.33 
                 −1.14 
               
               
                   
                 Ela1 
                 −1.49 
                 −1.69 
                 −1.98 
                 −2.1 
               
               
                   
                 Elavl1 
                 0.05 
                 0 
                 −0.63 
                 −1.78 
               
               
                   
                 Elf2 
                 0.63 
                 1.17 
                 0.61 
                 0.44 
               
               
                   
                 Elf3 
                 −0.06 
                 0.41 
                 0.81 
                 1.01 
               
               
                   
                 Elf5 
                 −1.85 
                 −1.89 
                 −1.7 
                 −2.46 
               
               
                   
                 Ell2 
                 0.91 
                 1.09 
                 1.02 
                 1.22 
               
               
                   
                 Ell3 
                 0.68 
                 1.09 
                 0.67 
                 1.21 
               
               
                   
                 Elovl5 
                 0.55 
                 0.32 
                 0.84 
                 1.07 
               
               
                   
                 Emd 
                 0.57 
                 0.52 
                 0.64 
                 1.03 
               
               
                   
                 Eme1 
                 3.94 
                 1.65 
                 3.36 
                 1.39 
               
               
                   
                 Emid1 
                 −2.24 
                 −1.37 
                 −1.69 
                 −2.4 
               
               
                   
                 Emp1 
                 1.45 
                 0.82 
                 0.86 
                 1.34 
               
               
                   
                 Emp2 
                 0.62 
                 0.54 
                 0.06 
                 −1.71 
               
               
                   
                 Enah 
                 −0.34 
                 −0.39 
                 −0.93 
                 −1.02 
               
               
                   
                 Enc1 
                 −1.38 
                 −0.93 
                 −0.6 
                 0.06 
               
               
                   
                 Enpp1 
                 0.45 
                 0.47 
                 −0.57 
                 −1.38 
               
               
                   
                 Enpp5 
                 −0.48 
                 −0.22 
                 −0.49 
                 −1.41 
               
               
                   
                 Entpd3 
                 −0.91 
                 −0.83 
                 −1.16 
                 −1.62 
               
               
                   
                 Entpd4 
                 −0.92 
                 −1.16 
                 −0.74 
                 −0.23 
               
               
                   
                 Entpd5 
                 −0.37 
                 −0.32 
                 −1.38 
                 −1.81 
               
               
                   
                 Epb4.1l3 
                 −1.47 
                 −2.25 
                 −2.54 
                 −3.31 
               
               
                   
                 Epb4.1l4a 
                 −0.72 
                 −1.16 
                 −0.61 
                 −0.91 
               
               
                   
                 Epb4.9 
                 −0.95 
                 −1.31 
                 −1.17 
                 −1.26 
               
               
                   
                 Ephb2 
                 −0.56 
                 −1.17 
                 0.46 
                 0.46 
               
               
                   
                 Ephx1 
                 −1.54 
                 −1.14 
                 −1.02 
                 −1.31 
               
               
                   
                 Ephx2 
                 −1.28 
                 −1.13 
                 −1.37 
                 −1.08 
               
               
                   
                 Epm2aip1 
                 −0.43 
                 −0.62 
                 −0.57 
                 −1.55 
               
               
                   
                 Eppk1 
                 1.15 
                 0.63 
                 1.05 
                 1.18 
               
               
                   
                 Epsti1 
                 0 
                 0 
                 1.35 
                 1.44 
               
               
                   
                 Erbb2ip 
                 0.15 
                 0 
                 −0.31 
                 −2.06 
               
               
                   
                 Ercc6l 
                 3.11 
                 2.69 
                 3.44 
                 2.57 
               
               
                   
                 Ern1 
                 −1.35 
                 −1.08 
                 −1.11 
                 −0.66 
               
               
                   
                 Ero1l 
                 1.77 
                 1.12 
                 0.24 
                 1.16 
               
               
                   
                 Errfi1 
                 0.94 
                 1.51 
                 0.9 
                 −0.19 
               
               
                   
                 Esco2 
                 3.24 
                 3.28 
                 3.35 
                 2.84 
               
               
                   
                 Espl1 
                 2.43 
                 2.09 
                 4.14 
                 1.92 
               
               
                   
                 Etv6 
                 0.03 
                 0 
                 −0.02 
                 −2.19 
               
               
                   
                 Eva1 
                 0.48 
                 0.88 
                 −0.68 
                 −1.1 
               
               
                   
                 Exdl1 
                 −0.96 
                 −1.1 
                 −1.25 
                 −0.58 
               
               
                   
                 Exo1 
                 5.45 
                 3.23 
                 2.55 
                 2.36 
               
               
                   
                 Exoc4 
                 −0.03 
                 0 
                 −0.64 
                 −1.71 
               
               
                   
                 Exod1 
                 0.92 
                 1.02 
                 0.9 
                 0.12 
               
               
                   
                 Exosc2 
                 0.97 
                 1.15 
                 0.82 
                 0.68 
               
               
                   
                 Exosc6 
                 0.6 
                 0.67 
                 0.7 
                 1.21 
               
               
                   
                 Exosc8 
                 1.41 
                 1.41 
                 1.33 
                 1.43 
               
               
                   
                 Ext1 
                 −0.35 
                 0 
                 −0.51 
                 −2.33 
               
               
                   
                 Ezh2 
                 0.98 
                 1.29 
                 1 
                 1.67 
               
               
                   
                 F2r 
                 −1.69 
                 −1.78 
                 −0.47 
                 0.59 
               
               
                   
                 F2rl1 
                 0.54 
                 1.04 
                 0.52 
                 0.86 
               
               
                   
                 F3 
                 0 
                 4.44 
                 1.21 
                 1.58 
               
               
                   
                 Faah 
                 −1.21 
                 −1.07 
                 0.32 
                 −0.23 
               
               
                   
                 Fabp4 
                 0.14 
                 −0.71 
                 −0.69 
                 −1.74 
               
               
                   
                 Fads2 
                 0.15 
                 −0.04 
                 −0.93 
                 −1.81 
               
               
                   
                 Faf1 
                 0.91 
                 1.18 
                 0.48 
                 −0.54 
               
               
                   
                 Falz 
                 −0.32 
                 −1.32 
                 −0.63 
                 −1.54 
               
               
                   
                 Fanca 
                 1.2 
                 0.84 
                 0.81 
                 1.02 
               
               
                   
                 Fancb 
                 0.76 
                 0.94 
                 1.09 
                 0.86 
               
               
                   
                 Fath2 
                 −0.6 
                 −1.06 
                 −1.05 
                 −1.36 
               
               
                   
                 Fbln1 
                 −1.87 
                 −0.97 
                 −0.96 
                 0 
               
               
                   
                 Fbln5 
                 −2.63 
                 −1.48 
                 −2.06 
                 0 
               
               
                   
                 Fbp1 
                 0.38 
                 0.3 
                 −0.23 
                 −1.08 
               
               
                   
                 Fbxl3 
                 0.43 
                 1.58 
                 0.51 
                 −1.01 
               
               
                   
                 Fbxo21 
                 −0.73 
                 −1.03 
                 −0.49 
                 −0.48 
               
               
                   
                 Fbxo39 
                 0.29 
                 1.01 
                 0.84 
                 1.2 
               
               
                   
                 Fbxo5 
                 2.06 
                 1.82 
                 2.39 
                 2.03 
               
               
                   
                 Fbxw11 
                 0.52 
                 1.2 
                 −0.37 
                 −2.08 
               
               
                   
                 Fbxw2 
                 0.71 
                 0.97 
                 0.3 
                 −1.18 
               
               
                   
                 Fbxw7 
                 −0.2 
                 −1.09 
                 −0.34 
                 0.22 
               
               
                   
                 Fen1 
                 2.64 
                 2.96 
                 2.86 
                 2.11 
               
               
                   
                 Fer1l4 
                 −0.86 
                 −1.11 
                 −0.72 
                 −0.73 
               
               
                   
                 Fetub 
                 1.08 
                 1.44 
                 0.78 
                 0.63 
               
               
                   
                 Fgd4 
                 −0.64 
                 −1.11 
                 −0.92 
                 −0.69 
               
               
                   
                 Fgf1 
                 −2.02 
                 −1.64 
                 −1.78 
                 −2.61 
               
               
                   
                 Fgfr2 
                 0.15 
                 0.21 
                 −0.96 
                 −1.57 
               
               
                   
                 Fhl1 
                 −2.3 
                 −1.93 
                 −1.73 
                 −1.87 
               
               
                   
                 Fignl1 
                 3.52 
                 3.12 
                 5.22 
                 2.68 
               
               
                   
                 Fjx1 
                 −0.82 
                 −1.5 
                 −0.99 
                 0 
               
               
                   
                 Flnb 
                 0.56 
                 −1.04 
                 −0.08 
                 −1.47 
               
               
                   
                 Flot2 
                 0.21 
                 0.38 
                 0.73 
                 2.31 
               
               
                   
                 Flrt3 
                 −0.7 
                 −1.39 
                 −1.99 
                 −1.36 
               
               
                   
                 Fmo2 
                 −2.34 
                 −1.98 
                 −1.03 
                 −2.07 
               
               
                   
                 Fmo5 
                 −1.55 
                 −1.3 
                 −1.03 
                 −2.04 
               
               
                   
                 Fn1 
                 −1.21 
                 −1.17 
                 −1.21 
                 0.52 
               
               
                   
                 Foxm1 
                 0.86 
                 3.46 
                 1.56 
                 1.72 
               
               
                   
                 Foxm1 /// Pebp1 /// 
                 2.75 
                 2.49 
                 2.43 
                 2.65 
               
               
                   
                 4933413G19Rik 
               
               
                   
                 Foxp2 
                 −0.7 
                 −1.1 
                 −1.41 
                 −1.23 
               
               
                   
                 Fras1 
                 −0.33 
                 −0.67 
                 −1.28 
                 −0.44 
               
               
                   
                 Fry 
                 −1.05 
                 −1.15 
                 −0.86 
                 −0.93 
               
               
                   
                 Fscn1 
                 0.75 
                 0.9 
                 −0.49 
                 −1.61 
               
               
                   
                 Fshprh1 
                 4.7 
                 5.27 
                 3.87 
                 3 
               
               
                   
                 Fstl1 
                 −2.34 
                 −1.77 
                 −1.57 
                 −0.33 
               
               
                   
                 Fubp1 
                 0.03 
                 −0.35 
                 0.13 
                 −2.17 
               
               
                   
                 Fusip1 
                 0.9 
                 1.02 
                 0.64 
                 0.22 
               
               
                   
                 Fut4 
                 −1.11 
                 −0.97 
                 −1.25 
                 −2.59 
               
               
                   
                 Fut9 
                 −0.8 
                 −1.05 
                 0.03 
                 −0.37 
               
               
                   
                 Fxyd4 
                 2.15 
                 1.14 
                 0.98 
                 1.87 
               
               
                   
                 Fxyd6 
                 0.99 
                 1.26 
                 1.75 
                 2.26 
               
               
                   
                 Fyco1 
                 −1.05 
                 −1.2 
                 −0.71 
                 −1.29 
               
               
                   
                 Fzd2 
                 −1.45 
                 −1.36 
                 −1.13 
                 −2.36 
               
               
                   
                 Fzd6 
                 0.49 
                 1.03 
                 −0.16 
                 −0.93 
               
               
                   
                 G6pd2 /// G6pdx 
                 0.26 
                 0.15 
                 −0.63 
                 −1.77 
               
               
                   
                 Gabpb1 
                 1.04 
                 1.76 
                 0.91 
                 0.51 
               
               
                   
                 Gabrp 
                 0 
                 0.58 
                 1.43 
                 0.39 
               
               
                   
                 Gadd45a 
                 −0.89 
                 −0.82 
                 −1.09 
                 −0.79 
               
               
                   
                 Gadd45b 
                 −0.03 
                 0.83 
                 1.09 
                 1.74 
               
               
                   
                 Galnt10 
                 −0.81 
                 −0.98 
                 −0.47 
                 −1.08 
               
               
                   
                 Galnt12 
                 0.8 
                 1.16 
                 0.74 
                 0.43 
               
               
                   
                 Galnt4 
                 −0.67 
                 −0.22 
                 −0.38 
                 −1.08 
               
               
                   
                 Galnt6 
                 0.81 
                 0.35 
                 −1.05 
                 −2.06 
               
               
                   
                 Galnt7 
                 −0.23 
                 0.34 
                 −0.43 
                 −1.37 
               
               
                   
                 Galntl1 
                 −2.69 
                 −2.73 
                 −2.59 
                 −3.28 
               
               
                   
                 Garnl1 
                 0.65 
                 0.85 
                 0.32 
                 −1.11 
               
               
                   
                 Garnl4 
                 −1.48 
                 −1.08 
                 −1.15 
                 −1.38 
               
               
                   
                 Gas6 
                 −1.75 
                 −1.56 
                 −2.03 
                 −2.11 
               
               
                   
                 Gata6 
                 −0.43 
                 −1.16 
                 −1.61 
                 −1.98 
               
               
                   
                 Gcn5l2 
                 −0.17 
                 −0.52 
                 −1.07 
                 −1.04 
               
               
                   
                 Gcnt1 
                 −0.46 
                 −0.32 
                 −1.22 
                 −1.21 
               
               
                   
                 Gcnt2 
                 −1.99 
                 −2.13 
                 −1.94 
                 −1.18 
               
               
                   
                 Gdap10 
                 −0.26 
                 −0.67 
                 0.01 
                 −1.53 
               
               
                   
                 Gdi2 
                 0.55 
                 0.66 
                 −0.21 
                 −1.82 
               
               
                   
                 Gdpd5 
                 −0.91 
                 −0.95 
                 −1.12 
                 −0.77 
               
               
                   
                 Gem 
                 −0.03 
                 0.3 
                 −0.56 
                 −1.03 
               
               
                   
                 Gemin6 
                 1.14 
                 1.1 
                 1.61 
                 1.23 
               
               
                   
                 Gfra3 
                 −1.67 
                 −1.84 
                 −1.26 
                 −2.22 
               
               
                   
                 Gga2 
                 −0.61 
                 −0.69 
                 −0.95 
                 −1.52 
               
               
                   
                 Gig1 
                 −0.61 
                 −1.22 
                 −0.92 
                 −0.11 
               
               
                   
                 Gins4 
                 2.21 
                 1.77 
                 1.94 
                 1.64 
               
               
                   
                 Gipc2 
                 1.16 
                 0.56 
                 0.62 
                 1.03 
               
               
                   
                 Gjb6 
                 −0.32 
                 −0.22 
                 −0.71 
                 −1.19 
               
               
                   
                 Gldc 
                 −1.06 
                 −0.67 
                 −0.27 
                 −0.89 
               
               
                   
                 Glrx 
                 −0.3 
                 −0.49 
                 −0.42 
                 −1.92 
               
               
                   
                 Gls 
                 −0.82 
                 −1.39 
                 −0.48 
                 −0.85 
               
               
                   
                 Gm1752 
                 −1.02 
                 −1.02 
                 −0.32 
                 −0.45 
               
               
                   
                 Gm70 
                 −0.34 
                 −0.59 
                 −1.18 
                 −1.12 
               
               
                   
                 Gm967 
                 −0.55 
                 −0.42 
                 −1.1 
                 −1.07 
               
               
                   
                 Gmcl1 
                 0.52 
                 1.42 
                 0.14 
                 −1.66 
               
               
                   
                 Gmfb 
                 0.28 
                 0.41 
                 −0.11 
                 −2.25 
               
               
                   
                 Gmnn 
                 2.34 
                 1.93 
                 2.15 
                 2.1 
               
               
                   
                 Gna13 
                 0.59 
                 1.19 
                 0.11 
                 0.05 
               
               
                   
                 Gna-rs1 
                 0.03 
                 0.12 
                 0.55 
                 1.21 
               
               
                   
                 Gne 
                 −1.77 
                 −1.98 
                 −1.49 
                 −2.22 
               
               
                   
                 Gng10 
                 0.08 
                 0.13 
                 0.62 
                 1.04 
               
               
                   
                 Gns 
                 −1.38 
                 −1.22 
                 −0.81 
                 −0.79 
               
               
                   
                 Golgb1 
                 −0.66 
                 −1.13 
                 −0.43 
                 −0.59 
               
               
                   
                 Golph3 
                 0.4 
                 1.08 
                 −0.33 
                 −1.98 
               
               
                   
                 Golph3l 
                 0.31 
                 1.15 
                 −0.61 
                 −1.03 
               
               
                   
                 Golph4 
                 −0.32 
                 −0.38 
                 −1.06 
                 −1.65 
               
               
                   
                 Gorasp1 
                 −0.67 
                 −0.56 
                 −0.71 
                 −1.08 
               
               
                   
                 Gorasp2 
                 0.17 
                 0.29 
                 −0.36 
                 −1.51 
               
               
                   
                 Got1 
                 −0.27 
                 −0.24 
                 −0.82 
                 −1.66 
               
               
                   
                 Got2 
                 0.42 
                 0.33 
                 −0.32 
                 −1.8 
               
               
                   
                 Gpa33 
                 0.37 
                 0.7 
                 −0.52 
                 −2.5 
               
               
                   
                 Gpam 
                 0.09 
                 0.55 
                 −0.85 
                 −2.27 
               
               
                   
                 Gpbp1 
                 0.84 
                 1.27 
                 −0.05 
                 −1.56 
               
               
                   
                 Gpc4 
                 −1.41 
                 −1.29 
                 −1.45 
                 −1.69 
               
               
                   
                 Gpiap1 
                 0.88 
                 1.04 
                 −0.38 
                 −1.98 
               
               
                   
                 Gpihbp1 
                 1.51 
                 1.66 
                 1.21 
                 3.27 
               
               
                   
                 Gpld1 
                 −1.09 
                 −1.21 
                 −1.25 
                 −1.38 
               
               
                   
                 Gpm6a 
                 −0.92 
                 0 
                 −3.24 
                 −2 
               
               
                   
                 Gpr109a 
                 1.03 
                 0.94 
                 0.13 
                 −0.35 
               
               
                   
                 Gpr115 
                 1.2 
                 0.86 
                 0.95 
                 1.08 
               
               
                   
                 Gpr137b 
                 −1.02 
                 −0.66 
                 −0.43 
                 −0.49 
               
               
                   
                 Gpr39 
                 −0.15 
                 −0.07 
                 −0.32 
                 −1.01 
               
               
                   
                 Gpr64 
                 −0.53 
                 −0.94 
                 −1.57 
                 −0.94 
               
               
                   
                 Gprc5a 
                 1.3 
                 1.44 
                 0.8 
                 1.43 
               
               
                   
                 Gprk6 
                 0.32 
                 0.59 
                 0.6 
                 1.2 
               
               
                   
                 Gpsm2 
                 1.16 
                 1.32 
                 1.21 
                 1.48 
               
               
                   
                 Gpt1 
                 −0.75 
                 −0.36 
                 −1.01 
                 −1.16 
               
               
                   
                 Gpx2 
                 0.85 
                 0.37 
                 1.5 
                 0.69 
               
               
                   
                 Gpx3 
                 −1.97 
                 −1.79 
                 −1.53 
                 −2.05 
               
               
                   
                 Grhl2 
                 −0.51 
                 −0.7 
                 −0.65 
                 −1.16 
               
               
                   
                 Grina 
                 −1.06 
                 −1.13 
                 −0.71 
                 −0.39 
               
               
                   
                 Gsg2 
                 4.64 
                 4.08 
                 3.91 
                 2.39 
               
               
                   
                 Gsta3 
                 −0.89 
                 −1.28 
                 −1.51 
                 −2.49 
               
               
                   
                 Gstm1 
                 −0.51 
                 −0.54 
                 −0.92 
                 −1.65 
               
               
                   
                 Gstm1 /// 
                 −1.2 
                 −0.91 
                 −1.59 
                 −2.2 
               
               
                   
                 LOC433943 /// 
               
               
                   
                 LOC674086 
               
               
                   
                 Gstm2 
                 −0.07 
                 −0.02 
                 −1.08 
                 −1.03 
               
               
                   
                 Gstm3 
                 −0.88 
                 −0.87 
                 −1.39 
                 −2.82 
               
               
                   
                 Gstm4 
                 −0.74 
                 −0.54 
                 −1.01 
                 −1.34 
               
               
                   
                 Gstm5 
                 0.03 
                 2.62 
                 0.46 
                 2.16 
               
               
                   
                 Gstt3 
                 −0.64 
                 −0.58 
                 −0.58 
                 −1.07 
               
               
                   
                 Gtf2h4 
                 0.49 
                 0.19 
                 0.6 
                 1.08 
               
               
                   
                 Gtf2i /// 
                 −0.28 
                 −0.07 
                 −0.36 
                 −1.78 
               
               
                   
                 LOC669007 
               
               
                   
                 Gtl2 
                 −2.35 
                 −4.7 
                 −4.06 
                 −5.59 
               
               
                   
                 Gtl2 /// Lphn1 
                 −1.29 
                 −3.28 
                 −2.07 
                 −4.05 
               
               
                   
                 Gtlf3b 
                 −0.94 
                 −0.97 
                 −1 
                 −0.97 
               
               
                   
                 Gtpbp2 
                 0.68 
                 1.17 
                 0.77 
                 −0.68 
               
               
                   
                 Gtse1 
                 1.34 
                 1.11 
                 0.8 
                 1.19 
               
               
                   
                 H19 
                 4.7 
                 2.52 
                 1.68 
                 4.19 
               
               
                   
                 H1f0 
                 1.74 
                 1.95 
                 1.45 
                 1.22 
               
               
                   
                 H1fx 
                 0.89 
                 0.81 
                 1.73 
                 2.5 
               
               
                   
                 H2-Aa 
                 −1.03 
                 −0.62 
                 0.12 
                 0.41 
               
               
                   
                 H2afv 
                 0.84 
                 0.82 
                 0.88 
                 1.11 
               
               
                   
                 H2afx 
                 1.61 
                 1.59 
                 2.02 
                 2.34 
               
               
                   
                 H2afz /// 
                 0.89 
                 0.73 
                 1.26 
                 1.47 
               
               
                   
                 LOC631864 /// 
               
               
                   
                 LOC675899 
               
               
                   
                 H2-B1 
                 −1.39 
                 −0.91 
                 −1.51 
                 −1.63 
               
               
                   
                 H2-K1 
                 −1.65 
                 −0.68 
                 0.14 
                 0.3 
               
               
                   
                 Hadhsc 
                 −0.16 
                 −1 
                 −0.32 
                 −0.28 
               
               
                   
                 Hars 
                 0.21 
                 −0.03 
                 0.38 
                 1.14 
               
               
                   
                 Hars2 
                 −1.06 
                 −0.91 
                 −0.61 
                 −0.87 
               
               
                   
                 Has3 
                 1.09 
                 0.65 
                 −0.11 
                 −0.55 
               
               
                   
                 Hat1 
                 1.8 
                 1.85 
                 1.21 
                 1.38 
               
               
                   
                 Hbld2 
                 0.3 
                 0.52 
                 −0.35 
                 −1.02 
               
               
                   
                 Hbp1 
                 0.42 
                 0.88 
                 −0.17 
                 −1.78 
               
               
                   
                 Hbs1l 
                 1.02 
                 1.34 
                 0.12 
                 −1.04 
               
               
                   
                 Hccs 
                 0.94 
                 1.32 
                 0.64 
                 −0.54 
               
               
                   
                 Hcfc1 
                 0.64 
                 1.07 
                 0.94 
                 −0.29 
               
               
                   
                 Hck 
                 −0.57 
                 −0.61 
                 −0.31 
                 −1.1 
               
               
                   
                 Hdac11 
                 −1.57 
                 −1.45 
                 −1.16 
                 −1.6 
               
               
                   
                 Hdgf 
                 0.61 
                 0.48 
                 1.07 
                 1.4 
               
               
                   
                 Hebp2 
                 0.23 
                 0.5 
                 1.06 
                 0.7 
               
               
                   
                 Helb 
                 0.47 
                 0.86 
                 1.06 
                 1.01 
               
               
                   
                 Hells 
                 3.2 
                 3.6 
                 2.94 
                 3.05 
               
               
                   
                 Hemk2 
                 −0.85 
                 −1.01 
                 −0.59 
                 0.04 
               
               
                   
                 Herpud1 
                 −0.56 
                 −0.51 
                 −0.66 
                 −1.05 
               
               
                   
                 Hexim1 
                 −0.33 
                 −0.06 
                 0.19 
                 −1.05 
               
               
                   
                 Hif1a 
                 1.54 
                 1.61 
                 −0.05 
                 −1.75 
               
               
                   
                 Higd1a 
                 1.12 
                 0.7 
                 0.57 
                 1.64 
               
               
                   
                 Hip1r 
                 −0.24 
                 −0.16 
                 −0.62 
                 −1.61 
               
               
                   
                 Hirip3 
                 1.74 
                 2.13 
                 1.84 
                 1.78 
               
               
                   
                 Hist1h1c 
                 0.89 
                 0.78 
                 0.48 
                 1.31 
               
               
                   
                 Hist1h4h /// 
                 2.01 
                 0.82 
                 0.36 
                 1.03 
               
               
                   
                 Hist1h4c /// 
               
               
                   
                 Hist1h4i /// 
               
               
                   
                 Hist1h4j /// 
               
               
                   
                 Hist1h4k /// 
               
               
                   
                 Hist1h4m /// 
               
               
                   
                 Hist1h4a /// 
               
               
                   
                 Hist1h4b 
               
               
                   
                 Hist1h4i 
                 1.26 
                 0.58 
                 0.23 
                 0.81 
               
               
                   
                 Hist2h2be 
                 1.07 
                 1.29 
                 1.67 
                 1.74 
               
               
                   
                 Hist2h3c1 /// 
                 −1.41 
                 −2.11 
                 −1.36 
                 −0.8 
               
               
                   
                 Hist2h2aa1 /// 
               
               
                   
                 Hist1h2ad /// 
               
               
                   
                 Hist1h2an /// 
               
               
                   
                 Hist2h2ab /// 
               
               
                   
                 Hist2h2ac /// 
               
               
                   
                 Hist2h2aa2 
               
               
                   
                 Hist2h3c1 /// 
                 1.73 
                 1.2 
                 0.59 
                 0.45 
               
               
                   
                 Hist2h3c2 /// 
               
               
                   
                 Hist1h3g /// 
               
               
                   
                 Hist1h3f /// 
               
               
                   
                 Hist1h3c /// 
               
               
                   
                 Hist1h3d /// 
               
               
                   
                 Hist1h3b /// 
               
               
                   
                 Hist1h3e /// 
               
               
                   
                 Hist1h3h /// 
               
               
                   
                 Hist1h3i /// 
               
               
                   
                 Hist2h3b /// 
               
               
                   
                 Hist1h3a 
               
               
                   
                 Hk2 
                 1.54 
                 0.58 
                 0.02 
                 1.25 
               
               
                   
                 Hlcs 
                 −0.58 
                 −0.6 
                 −0.64 
                 −1.04 
               
               
                   
                 Hmg20a 
                 −0.29 
                 −0.62 
                 −0.64 
                 −1.79 
               
               
                   
                 Hmgb1 /// 
                 1.03 
                 1.31 
                 0.61 
                 −0.11 
               
               
                   
                 4932431P20Rik /// 
               
               
                   
                 LOC432959 /// 
               
               
                   
                 LOC434174 /// 
               
               
                   
                 LOC545555 /// 
               
               
                   
                 LOC637733 /// 
               
               
                   
                 LOC640060 /// 
               
               
                   
                 LOC667777 /// 
               
               
                   
                 LOC669546 
               
               
                   
                 Hmgb2 /// 
                 2.46 
                 2.84 
                 2.72 
                 1.99 
               
               
                   
                 LOC433785 /// 
               
               
                   
                 LOC678110 /// 
               
               
                   
                 LOC678341 
               
               
                   
                 Hmgb2 /// 
                 1.96 
                 2.42 
                 1.78 
                 2.08 
               
               
                   
                 LOC678110 /// 
               
               
                   
                 LOC678341 
               
               
                   
                 Hmgcs2 
                 −0.54 
                 −0.85 
                 −1.69 
                 −2.16 
               
               
                   
                 Hmgn2 
                 1 
                 1.46 
                 1.57 
                 1.52 
               
               
                   
                 RHAMM 
                 3.56 
                 2.97 
                 3.16 
                 1.76 
               
               
                   
                 Hmox1 
                 1.01 
                 1 
                 −0.07 
                 0.42 
               
               
                   
                 Hn1 
                 0.43 
                 0.95 
                 0.44 
                 1.73 
               
               
                   
                 Hnrpd 
                 0.77 
                 0.42 
                 0.53 
                 1.17 
               
               
                   
                 Hnrpl 
                 0.5 
                 0.67 
                 0.8 
                 1.07 
               
               
                   
                 Hnrpr 
                 0.88 
                 1.02 
                 0.5 
                 −0.58 
               
               
                   
                 Hnrpu 
                 0.23 
                 −0.09 
                 0.39 
                 −1.27 
               
               
                   
                 Hpgd 
                 −1.11 
                 −0.84 
                 −0.68 
                 −0.2 
               
               
                   
                 Hr 
                 −0.42 
                 0.13 
                 1.09 
                 0.28 
               
               
                   
                 Hrsp12 
                 −0.87 
                 −1.16 
                 −1.12 
                 −1.17 
               
               
                   
                 Hs1bp3 
                 −0.4 
                 −1.02 
                 −0.19 
                 −0.45 
               
               
                   
                 Hs3st1 
                 0.81 
                 1.02 
                 0.46 
                 0.7 
               
               
                   
                 Hsd17b12 
                 0.42 
                 0.65 
                 0 
                 −1.18 
               
               
                   
                 Hsd17b2 
                 −0.97 
                 −1.45 
                 −1.75 
                 −1.79 
               
               
                   
                 Hsp110 
                 0.43 
                 1.08 
                 −0.15 
                 −0.31 
               
               
                   
                 Hspa14 
                 0.85 
                 1.08 
                 1.09 
                 1.35 
               
               
                   
                 Hspa1a 
                 1.13 
                 1.77 
                 0.35 
                 1.04 
               
               
                   
                 Hspa4 
                 −0.16 
                 −0.29 
                 −0.23 
                 −1.43 
               
               
                   
                 Hspa4l 
                 1 
                 1.18 
                 1.03 
                 0.33 
               
               
                   
                 Htatip2 
                 −0.64 
                 −0.87 
                 −1.09 
                 −1.06 
               
               
                   
                 Htr4 
                 −0.78 
                 −0.85 
                 −1.48 
                 −1.49 
               
               
                   
                 Htra1 
                 −3.49 
                 −2.4 
                 −1.95 
                 −0.46 
               
               
                   
                 Htra2 
                 −0.03 
                 0.17 
                 0.22 
                 1.05 
               
               
                   
                 Ibrdc1 
                 0.21 
                 0.21 
                 0.18 
                 1.04 
               
               
                   
                 Ibrdc2 
                 −0.23 
                 0.07 
                 −0.89 
                 −1.97 
               
               
                   
                 Ibrdc3 
                 0.17 
                 0.36 
                 0.75 
                 1.16 
               
               
                   
                 Ica1 
                 0.29 
                 0.67 
                 −0.08 
                 −1.41 
               
               
                   
                 Icosl 
                 −0.21 
                 −0.24 
                 −0.14 
                 −1.11 
               
               
                   
                 Id2 
                 −0.38 
                 −0.31 
                 −0.35 
                 −1.88 
               
               
                   
                 Id4 
                 −1.5 
                 −1.34 
                 −0.76 
                 −3.41 
               
               
                   
                 Ide 
                 0.38 
                 0.89 
                 −0.01 
                 −1.78 
               
               
                   
                 Idh1 
                 0 
                 0.08 
                 −0.35 
                 −1.04 
               
               
                   
                 Ids 
                 −1.17 
                 −1.01 
                 −0.53 
                 −0.49 
               
               
                   
                 Ier3 
                 0.79 
                 0.9 
                 0.64 
                 1.01 
               
               
                   
                 Ifi202b 
                 2.09 
                 2.3 
                 0.86 
                 3.59 
               
               
                   
                 Ifi203 
                 1.97 
                 3.26 
                 1.62 
                 2.49 
               
               
                   
                 Ifi30 
                 0.67 
                 0.78 
                 1.12 
                 1.04 
               
               
                   
                 Ifih1 
                 0.21 
                 0.8 
                 0.82 
                 1.4 
               
               
                   
                 Ifit1 
                 1.46 
                 1.93 
                 1.59 
                 3.18 
               
               
                   
                 Ifit2 
                 1.66 
                 2.16 
                 2.1 
                 2.91 
               
               
                   
                 Ifnz 
                 1.59 
                 0.94 
                 1.5 
                 1.69 
               
               
                   
                 Ifrd1 
                 0.84 
                 1.08 
                 0.75 
                 1.03 
               
               
                   
                 Ift57 
                 0 
                 −0.06 
                 1.05 
                 0.7 
               
               
                   
                 Igf1r 
                 0.18 
                 0 
                 −0.86 
                 −1.97 
               
               
                   
                 Igf2 
                 −0.48 
                 0.06 
                 −1.01 
                 1.56 
               
               
                   
                 Igf2bp3 
                 0.97 
                 1.49 
                 0 
                 0 
               
               
                   
                 Igfbp2 
                 −0.23 
                 −0.35 
                 −0.79 
                 −2.01 
               
               
                   
                 Igfbp3 
                 0.56 
                 0.6 
                 1.08 
                 2.15 
               
               
                   
                 Igfbp4 
                 −1.62 
                 −1.26 
                 −1.28 
                 0.27 
               
               
                   
                 Igfbp5 
                 −1.13 
                 −1.26 
                 −2.25 
                 −1.17 
               
               
                   
                 Igfbp6 
                 −0.76 
                 0 
                 −1.65 
                 −1.45 
               
               
                   
                 Igk-V28 /// Igk-V8- 
                 0 
                 −1.12 
                 0 
                 1.86 
               
               
                   
                 16 
               
               
                   
                 Igsf4a 
                 0.27 
                 −0.1 
                 0.62 
                 1.06 
               
               
                   
                 Igsf4c 
                 1.97 
                 1.86 
                 1.42 
                 2.04 
               
               
                   
                 Igsf9 
                 0.38 
                 0.61 
                 0.62 
                 1.02 
               
               
                   
                 Igtp 
                 −0.58 
                 0.73 
                 0.54 
                 1.6 
               
               
                   
                 Il13ra1 
                 0.47 
                 1.15 
                 0.29 
                 −0.09 
               
               
                   
                 Il17re 
                 −0.83 
                 −0.93 
                 −0.32 
                 −2.38 
               
               
                   
                 Il18 
                 0.8 
                 1.69 
                 1.52 
                 1.3 
               
               
                   
                 Il18r1 
                 −1.2 
                 −1.27 
                 0.39 
                 0.17 
               
               
                   
                 Il1rn 
                 2.35 
                 2.25 
                 1.36 
                 0 
               
               
                   
                 Il6st 
                 0.2 
                 1.36 
                 −0.44 
                 −1.97 
               
               
                   
                 Immt 
                 0.65 
                 0.6 
                 −0.26 
                 −1.55 
               
               
                   
                 Impa2 
                 0.5 
                 0.93 
                 1.11 
                 1.09 
               
               
                   
                 Impact 
                 −1.2 
                 −1.1 
                 −0.77 
                 −1.49 
               
               
                   
                 Incenp 
                 2.79 
                 2.93 
                 2.48 
                 2.26 
               
               
                   
                 Inmt 
                 −1.92 
                 −1.72 
                 −1.46 
                 0 
               
               
                   
                 Ints5 
                 0.19 
                 0.29 
                 0.5 
                 1.08 
               
               
                   
                 Ints6 
                 −1.73 
                 −2.27 
                 −2.71 
                 −2.51 
               
               
                   
                 Ints8 
                 0.96 
                 1.26 
                 0.59 
                 −1.45 
               
               
                   
                 Ipp 
                 0.33 
                 0.98 
                 1.07 
                 0.7 
               
               
                   
                 Iqgap3 
                 1.95 
                 1.97 
                 2.12 
                 2.19 
               
               
                   
                 Irf1 
                 −0.47 
                 0.07 
                 0.33 
                 1.03 
               
               
                   
                 Irf2 
                 0.16 
                 0 
                 −0.03 
                 −1.63 
               
               
                   
                 Irf7 
                 0.29 
                 0.84 
                 0.36 
                 1.93 
               
               
                   
                 Irf8 
                 −0.81 
                 −0.72 
                 −1.03 
                 −1.31 
               
               
                   
                 Irs1 
                 −0.18 
                 −0.55 
                 −1.08 
                 0 
               
               
                   
                 Isgf3g 
                 0.14 
                 1.23 
                 1.79 
                 1.4 
               
               
                   
                 Itgb5 
                 −1.12 
                 −0.92 
                 −0.96 
                 −1.31 
               
               
                   
                 Itgb6 
                 −1.38 
                 −1.58 
                 −1.28 
                 −1.1 
               
               
                   
                 Itpk1 
                 0.58 
                 0.35 
                 0.7 
                 1.08 
               
               
                   
                 Itpr1 
                 −0.23 
                 −0.24 
                 −0.31 
                 −1.09 
               
               
                   
                 Ivl 
                 0.21 
                 0.01 
                 −0.68 
                 −1.85 
               
               
                   
                 Jarid1d 
                 −4.58 
                 −1 
                 0 
                 2.73 
               
               
                   
                 Jmjd1c 
                 −0.25 
                 0 
                 −0.34 
                 −2.06 
               
               
                   
                 Jtv1 
                 0.5 
                 0.69 
                 0.55 
                 1.01 
               
               
                   
                 Jun 
                 2.66 
                 2.98 
                 2.35 
                 2.35 
               
               
                   
                 Jund1 
                 0.33 
                 0.17 
                 0.39 
                 1.6 
               
               
                   
                 Kazald1 
                 −1.03 
                 −1.22 
                 −1.17 
                 −1.07 
               
               
                   
                 Kbtbd11 /// 
                 −0.69 
                 −1.02 
                 −0.95 
                 −0.87 
               
               
                   
                 LOC632344 
               
               
                   
                 Kcne1 
                 −0.86 
                 −0.88 
                 −2.1 
                 −2.28 
               
               
                   
                 Kcnj15 
                 −2.67 
                 −3.47 
                 −3.34 
                 −1.25 
               
               
                   
                 Kcnk5 
                 0.77 
                 1.28 
                 1.17 
                 1.62 
               
               
                   
                 Kcnk6 
                 0.71 
                 1.17 
                 1.88 
                 1.78 
               
               
                   
                 Kcnmb4 
                 −1.1 
                 −0.81 
                 −0.84 
                 −0.64 
               
               
                   
                 Kcnn4 
                 −1.25 
                 −1.28 
                 −0.9 
                 −1.38 
               
               
                   
                 Kctd12b 
                 −2.26 
                 −2.7 
                 −1.6 
                 −2.25 
               
               
                   
                 Kctd15 
                 −1.09 
                 −1.2 
                 −1.29 
                 −1.92 
               
               
                   
                 Kctd3 
                 0.88 
                 1.02 
                 0.89 
                 0.47 
               
               
                   
                 Kdelr3 
                 0 
                 3.48 
                 1.62 
                 1.7 
               
               
                   
                 Khsrp 
                 −0.2 
                 −0.11 
                 0.38 
                 1.48 
               
               
                   
                 Kif11 
                 3.5 
                 5.89 
                 2.77 
                 2.04 
               
               
                   
                 Kif18a 
                 1.54 
                 1.88 
                 2.29 
                 2.07 
               
               
                   
                 Kif20a 
                 2.92 
                 2.28 
                 2.8 
                 2.22 
               
               
                   
                 Kif22 
                 4.37 
                 2.94 
                 5.47 
                 2.83 
               
               
                   
                 Kif23 
                 1.59 
                 1.7 
                 1.98 
                 1.61 
               
               
                   
                 Kif2c 
                 3.49 
                 2.03 
                 5.62 
                 2.5 
               
               
                   
                 Kif4 
                 2.63 
                 2.13 
                 2.1 
                 2.34 
               
               
                   
                 Kifc1 
                 2.63 
                 3.13 
                 1.9 
                 2.48 
               
               
                   
                 Klc3 
                 0.07 
                 0.26 
                 0.47 
                 1.09 
               
               
                   
                 Klf4 
                 0.57 
                 0.51 
                 0.62 
                 1.18 
               
               
                   
                 Klf5 
                 −0.1 
                 0.01 
                 −0.45 
                 −1.33 
               
               
                   
                 Klf6 
                 1.22 
                 1.23 
                 0.49 
                 0.12 
               
               
                   
                 Klhl14 
                 −4.31 
                 −1.57 
                 −1.66 
                 −2.69 
               
               
                   
                 Klhl22 
                 −0.33 
                 −1.64 
                 −1.71 
                 −0.72 
               
               
                   
                 Klhl24 
                 −0.51 
                 0 
                 −0.94 
                 −2.12 
               
               
                   
                 Klk6 
                 0.88 
                 0 
                 2.14 
                 1.69 
               
               
                   
                 Klk8 
                 −2.11 
                 −2.1 
                 −1.4 
                 −1.19 
               
               
                   
                 Kntc1 
                 2.97 
                 3.53 
                 5.32 
                 1.98 
               
               
                   
                 Kntc2 
                 2.61 
                 3.33 
                 3.13 
                 2.72 
               
               
                   
                 Kpna1 
                 0.79 
                 1.39 
                 0.13 
                 −0.53 
               
               
                   
                 Kpna2 /// 
                 1.54 
                 1.48 
                 1.42 
                 1.37 
               
               
                   
                 LOC670551 /// 
               
               
                   
                 LOC671639 
               
               
                   
                 Kpna3 
                 1.02 
                 1.01 
                 0.58 
                 −0.47 
               
               
                   
                 Kpnb1 
                 1.26 
                 1.02 
                 0.78 
                 −0.81 
               
               
                   
                 Krt1-14 
                 0 
                 0 
                 1.6 
                 2.91 
               
               
                   
                 Krt1-15 
                 −1.33 
                 −1.29 
                 −0.87 
                 −2.56 
               
               
                   
                 Krt1-23 
                 2.9 
                 2.87 
                 1.97 
                 2.2 
               
               
                   
                 Krt2-4 
                 0.01 
                 0.48 
                 1.1 
                 0.88 
               
               
                   
                 Krt2-5 
                 −0.39 
                 −0.78 
                 −0.88 
                 −1.88 
               
               
                   
                 Lactb 
                 −1.61 
                 −1.76 
                 −1.12 
                 −0.89 
               
               
                   
                 Lamb1-1 
                 −0.68 
                 −1.23 
                 −0.82 
                 −0.39 
               
               
                   
                 Lancl3 
                 −0.95 
                 −1.55 
                 −1.4 
                 −1.83 
               
               
                   
                 Laptm4a 
                 −0.41 
                 −0.16 
                 −0.46 
                 −1.16 
               
               
                   
                 Large 
                 −0.96 
                 −1.43 
                 −1.14 
                 −0.68 
               
               
                   
                 Lasp1 
                 1.03 
                 1.39 
                 −0.19 
                 −1.43 
               
               
                   
                 Lbh 
                 −0.72 
                 −1.19 
                 −1.16 
                 −0.86 
               
               
                   
                 Lbr 
                 1.28 
                 1.24 
                 1.9 
                 1.36 
               
               
                   
                 Lcn2 
                 0 
                 0 
                 0 
                 2.37 
               
               
                   
                 Ldha 
                 1.16 
                 1.07 
                 0.49 
                 1.09 
               
               
                   
                 Ldhb 
                 −0.81 
                 −1.22 
                 −1.49 
                 −2.07 
               
               
                   
                 Ldlrad3 
                 −0.51 
                 −0.53 
                 −0.84 
                 −1.21 
               
               
                   
                 Ldoc1 
                 1.86 
                 2.81 
                 2.5 
                 4.09 
               
               
                   
                 Leprel1 
                 −1.01 
                 −0.68 
                 −1.56 
                 −1.65 
               
               
                   
                 Lgals1 
                 −0.99 
                 −1.33 
                 −1.33 
                 −0.16 
               
               
                   
                 Lgals3 
                 0.41 
                 0 
                 0.87 
                 −1.08 
               
               
                   
                 Lig1 
                 1.9 
                 1.97 
                 1.96 
                 1.65 
               
               
                   
                 Lima1 
                 0.32 
                 0.44 
                 −0.58 
                 −1.65 
               
               
                   
                 Limd1 
                 −0.04 
                 −0.39 
                 0.35 
                 1.01 
               
               
                   
                 Limk2 
                 0.05 
                 0.05 
                 −0.39 
                 −1.15 
               
               
                   
                 Lims1 
                 0.52 
                 1.01 
                 −0.1 
                 −2.03 
               
               
                   
                 Lin7c 
                 0.76 
                 0.83 
                 −0.11 
                 −1.86 
               
               
                   
                 Lin9 
                 1.12 
                 1.62 
                 2.46 
                 1.67 
               
               
                   
                 Litaf 
                 0.84 
                 1.03 
                 0.23 
                 0.35 
               
               
                   
                 Lman2 
                 −0.54 
                 −0.2 
                 −0.48 
                 −1.06 
               
               
                   
                 Lmbr1 
                 −0.29 
                 −0.07 
                 −0.71 
                 −1.65 
               
               
                   
                 Lmnb1 
                 2.19 
                 1.64 
                 1.79 
                 1.45 
               
               
                   
                 Lmo1 
                 −0.88 
                 −1.19 
                 −1.48 
                 −1.75 
               
               
                   
                 Lonrf2 
                 −0.5 
                 −0.55 
                 −1.28 
                 −1.36 
               
               
                   
                 Lonrf3 
                 1.25 
                 2.28 
                 0.99 
                 1.07 
               
               
                   
                 Lpin1 
                 −1.01 
                 −0.94 
                 −1.32 
                 −2.5 
               
               
                   
                 Lpl 
                 −0.57 
                 0.24 
                 0.21 
                 1.32 
               
               
                   
                 Lpp 
                 −0.61 
                 −1.42 
                 −0.73 
                 −0.28 
               
               
                   
                 Lrp1 
                 −0.45 
                 −0.89 
                 −0.96 
                 −1.09 
               
               
                   
                 Lrrc33 
                 −2.71 
                 −1.74 
                 −1.28 
                 −4.25 
               
               
                   
                 Lrrc50 
                 0 
                 0 
                 1.52 
                 1.15 
               
               
                   
                 Lrrc51 
                 −1.81 
                 −1.25 
                 −1.55 
                 −1.99 
               
               
                   
                 Lrrc54 
                 −0.82 
                 −1.52 
                 −1.04 
                 −1.32 
               
               
                   
                 Lrrc8e 
                 −0.38 
                 −0.27 
                 −0.43 
                 −1.14 
               
               
                   
                 Lsm2 
                 1.27 
                 1.61 
                 1.27 
                 1.25 
               
               
                   
                 Lsm3 
                 0.75 
                 0.8 
                 0.86 
                 1.14 
               
               
                   
                 Lsm5 
                 1.04 
                 0.89 
                 0.82 
                 1.13 
               
               
                   
                 Lsm8 
                 1.01 
                 0.87 
                 0.82 
                 1.51 
               
               
                   
                 Luc7l2 
                 −0.63 
                 −1.9 
                 −1.14 
                 −2.49 
               
               
                   
                 Lum 
                 −1.9 
                 −1.78 
                 −1.9 
                 0 
               
               
                   
                 Luzp1 
                 −0.44 
                 −0.44 
                 0.31 
                 1.06 
               
               
                   
                 Luzp5 
                 2.39 
                 2.52 
                 2.92 
                 2.44 
               
               
                   
                 Ly6c 
                 −0.76 
                 −0.18 
                 −0.16 
                 1.25 
               
               
                   
                 Ly6e 
                 −0.81 
                 0.23 
                 0.8 
                 1.02 
               
               
                   
                 Lynx1 
                 −1 
                 −0.85 
                 −0.3 
                 −0.36 
               
               
                   
                 Lypla1 
                 0.35 
                 0.5 
                 −0.46 
                 −1.56 
               
               
                   
                 Lyzs 
                 −0.36 
                 0.32 
                 0.23 
                 1.41 
               
               
                   
                 Lzic 
                 1.39 
                 0.87 
                 0.82 
                 0.55 
               
               
                   
                 Lzp-s 
                 −0.61 
                 0.25 
                 0.29 
                 2.13 
               
               
                   
                 Mad2l1 
                 3 
                 2.96 
                 3.11 
                 2.34 
               
               
                   
                 Mafb 
                 −1.08 
                 −0.89 
                 −1.27 
                 −1.19 
               
               
                   
                 Maff 
                 1 
                 1.64 
                 0.94 
                 1.52 
               
               
                   
                 Magoh 
                 0.64 
                 0.81 
                 0.84 
                 1.08 
               
               
                   
                 Malat1 
                 −1.14 
                 −1.56 
                 −0.31 
                 0.27 
               
               
                   
                 Man1a 
                 −0.48 
                 −0.35 
                 −0.54 
                 −1.03 
               
               
                   
                 Man1a2 
                 0.2 
                 0 
                 0 
                 −2.51 
               
               
                   
                 Man1c1 
                 −1.37 
                 −1.26 
                 −0.84 
                 −0.24 
               
               
                   
                 Map4k4 
                 0.42 
                 0.22 
                 0.96 
                 1.05 
               
               
                   
                 Map4k5 
                 1.07 
                 1.23 
                 0.29 
                 −0.64 
               
               
                   
                 Mapk14 
                 0.3 
                 1.11 
                 0.23 
                 −1.69 
               
               
                   
                 Mapk1ip1 
                 −0.76 
                 −1 
                 −0.62 
                 −0.83 
               
               
                   
                 Mapk6 
                 0.91 
                 1.28 
                 0.46 
                 0 
               
               
                   
                 Mapkapk5 
                 0.28 
                 0.49 
                 0.76 
                 1.12 
               
               
                   
                 Mapre2 
                 −1.3 
                 −1.53 
                 −1.42 
                 −0.25 
               
               
                   
                 Marcksl1 
                 −0.25 
                 1.61 
                 −0.79 
                 −0.13 
               
               
                   
                 Marveld1 
                 −1.33 
                 −0.92 
                 −0.96 
                 0.06 
               
               
                   
                 Mast2 
                 0.73 
                 0.74 
                 1.22 
                 1.26 
               
               
                   
                 Mast4 
                 −0.5 
                 0 
                 −0.82 
                 −2.77 
               
               
                   
                 Mastl 
                 2.63 
                 2.35 
                 2.49 
                 1.32 
               
               
                   
                 Maz 
                 0.29 
                 0.41 
                 1.19 
                 1.61 
               
               
                   
                 Mbd4 
                 1.21 
                 1.23 
                 1.38 
                 1.01 
               
               
                   
                 Mbd5 
                 −0.73 
                 −0.67 
                 −0.47 
                 −1.16 
               
               
                   
                 Mbnl2 
                 0.17 
                 0.1 
                 −0.21 
                 −1.55 
               
               
                   
                 Mbtd1 
                 −0.09 
                 0 
                 −0.79 
                 −1.44 
               
               
                   
                 Mcm10 
                 2.7 
                 2.33 
                 2.13 
                 2.09 
               
               
                   
                 Mcm2 
                 2.05 
                 2.29 
                 2.09 
                 2.24 
               
               
                   
                 Mcm3 /// 
                 2.9 
                 2.55 
                 2.86 
                 2.71 
               
               
                   
                 LOC671904 
               
               
                   
                 Mcm4 
                 1.86 
                 2.17 
                 1.54 
                 2.1 
               
               
                   
                 Mcm5 
                 3.25 
                 3.28 
                 2.81 
                 2.56 
               
               
                   
                 Mcm6 
                 3.7 
                 4.33 
                 3.34 
                 3.46 
               
               
                   
                 Mcm7 
                 1.39 
                 1.41 
                 1.33 
                 1.55 
               
               
                   
                 Mcm8 
                 1.26 
                 2.06 
                 1.79 
                 0.8 
               
               
                   
                 Mcpt1 
                 0 
                 0 
                 0 
                 4.69 
               
               
                   
                 Mcpt2 
                 0 
                 0 
                 0 
                 5.13 
               
               
                   
                 Mdm4 
                 −0.15 
                 −0.12 
                 −0.36 
                 −1.1 
               
               
                   
                 Me2 
                 0.78 
                 0.89 
                 1.13 
                 1.03 
               
               
                   
                 Mef2a 
                 −0.36 
                 −0.2 
                 −0.23 
                 −1.04 
               
               
                   
                 Meis1 
                 −0.5 
                 0 
                 −0.6 
                 −3 
               
               
                   
                 Melk 
                 3.7 
                 3.17 
                 4.49 
                 2.61 
               
               
                   
                 Mertk 
                 −0.28 
                 −0.53 
                 −1.21 
                 −0.82 
               
               
                   
                 Met 
                 0.84 
                 1.29 
                 0.22 
                 −1.57 
               
               
                   
                 Metrn 
                 1.38 
                 0.69 
                 1.14 
                 1.19 
               
               
                   
                 Mettl7a 
                 −0.67 
                 −1.12 
                 −0.89 
                 −1.67 
               
               
                   
                 Mettl7a /// Ubie 
                 −1.34 
                 −0.86 
                 −1.34 
                 −1.16 
               
               
                   
                 Mettl7a /// Ubie 
                 −0.39 
                 −0.27 
                 −0.94 
                 −1.28 
               
               
                   
                 /// LOC554292 
               
               
                   
                 Mfap3l 
                 0.05 
                 −0.25 
                 −0.76 
                 −1.75 
               
               
                   
                 Mfhas1 
                 −1.1 
                 −1.63 
                 −0.78 
                 −0.3 
               
               
                   
                 MGC73635 
                 2.96 
                 2.41 
                 2.95 
                 1.94 
               
               
                   
                 Mgp 
                 −2.27 
                 −1.75 
                 −1.21 
                 −0.57 
               
               
                   
                 Mia3 
                 −0.86 
                 −1.49 
                 −0.24 
                 0.41 
               
               
                   
                 Mier1 
                 0.86 
                 1.09 
                 0.82 
                 −0.9 
               
               
                   
                 Mki67 /// 
                 4.04 
                 2.31 
                 4.24 
                 2.32 
               
               
                   
                 LOC638774 
               
               
                   
                 Mlf1 
                 2.91 
                 2.03 
                 3.32 
                 2.62 
               
               
                   
                 Mlf1ip 
                 3.46 
                 1.16 
                 1.59 
                 1.3 
               
               
                   
                 Mlkl 
                 1.93 
                 1.33 
                 1.5 
                 1.21 
               
               
                   
                 Mllt4 
                 0.01 
                 0.29 
                 1.18 
                 1.05 
               
               
                   
                 Mlstd2 
                 1.77 
                 2.03 
                 0.23 
                 −1.69 
               
               
                   
                 Mlycd 
                 −0.61 
                 −1.07 
                 −0.7 
                 −0.74 
               
               
                   
                 Mlze 
                 1 
                 1.06 
                 1.2 
                 1.33 
               
               
                   
                 Mmp15 
                 −1.05 
                 −0.75 
                 0.28 
                 0.04 
               
               
                   
                 Mmp2 
                 −3.54 
                 −1.33 
                 −0.85 
                 0 
               
               
                   
                 Mmp7 
                 0 
                 0 
                 0 
                 2.51 
               
               
                   
                 Mnt 
                 −0.53 
                 −1.04 
                 −0.12 
                 0.07 
               
               
                   
                 Mobk1b 
                 0.88 
                 1.68 
                 −0.06 
                 −1.94 
               
               
                   
                 Mocs1 
                 −0.8 
                 −1.29 
                 −1.53 
                 −1.48 
               
               
                   
                 Mon1b 
                 −0.9 
                 −1.17 
                 −1.07 
                 −0.84 
               
               
                   
                 Mphosph1 
                 2.46 
                 2.77 
                 2.51 
                 1.98 
               
               
                   
                 Mpzl1 
                 0.13 
                 0.69 
                 0.77 
                 1.41 
               
               
                   
                 Mr1 
                 −0.5 
                 −0.56 
                 −1.15 
                 −2.51 
               
               
                   
                 Mre11a 
                 1.08 
                 1.24 
                 1.01 
                 0.81 
               
               
                   
                 Mrpl41 
                 0.31 
                 0.11 
                 0.34 
                 1.02 
               
               
                   
                 Mrpl9 
                 0.38 
                 0.47 
                 −0.21 
                 −1.37 
               
               
                   
                 Mrps2 
                 0.48 
                 1.03 
                 −0.22 
                 −1.01 
               
               
                   
                 Mrps23 
                 0.38 
                 0.49 
                 −0.47 
                 −1.15 
               
               
                   
                 Msh6 
                 1.01 
                 0.9 
                 1.03 
                 1.25 
               
               
                   
                 Msi2 
                 −0.31 
                 0 
                 −0.36 
                 −2.8 
               
               
                   
                 Msrb2 
                 −1.07 
                 −1.93 
                 −1.54 
                 −4.56 
               
               
                   
                 Msrb3 
                 0.74 
                 1.83 
                 1.44 
                 1.33 
               
               
                   
                 Mtac2d1 
                 −1.9 
                 −0.61 
                 −0.28 
                 −1.7 
               
               
                   
                 Mtap4 
                 0.11 
                 0.27 
                 0.62 
                 1.02 
               
               
                   
                 Mthfd1l 
                 1.2 
                 1.42 
                 0.93 
                 1.48 
               
               
                   
                 Mthfd2 
                 2.14 
                 1.35 
                 2.36 
                 2.43 
               
               
                   
                 Mtm1 
                 2.19 
                 1.81 
                 1.57 
                 −0.01 
               
               
                   
                 Mtmr2 
                 0.45 
                 1.01 
                 0.17 
                 −0.41 
               
               
                   
                 Mtmr4 
                 −0.5 
                 −0.03 
                 −0.43 
                 −1.13 
               
               
                   
                 Mtmr6 
                 0.17 
                 0.6 
                 −0.07 
                 −1.13 
               
               
                   
                 Mtss1 
                 0.19 
                 0.06 
                 −0.47 
                 −1.07 
               
               
                   
                 Mtus1 
                 −0.26 
                 0.4 
                 −0.28 
                 −1.22 
               
               
                   
                 Mxd1 
                 0.44 
                 0.87 
                 0.8 
                 1.36 
               
               
                   
                 Mxd3 
                 0 
                 0 
                 1.01 
                 2.39 
               
               
                   
                 Mxd4 
                 −1.2 
                 −0.92 
                 −0.69 
                 −0.4 
               
               
                   
                 Mxi1 
                 0.66 
                 1.33 
                 −0.19 
                 −1.43 
               
               
                   
                 Mxra8 
                 −1.29 
                 −0.62 
                 −0.72 
                 0.03 
               
               
                   
                 Mybl2 
                 1.8 
                 2.11 
                 1.74 
                 1.92 
               
               
                   
                 Mycl1 
                 0.45 
                 0.85 
                 −0.05 
                 −1.63 
               
               
                   
                 Myef2 
                 0.69 
                 0.63 
                 1.04 
                 1.28 
               
               
                   
                 Myh11 
                 −4.14 
                 −0.51 
                 −1.82 
                 0 
               
               
                   
                 Myl6 
                 −0.82 
                 −0.56 
                 −0.49 
                 −1.52 
               
               
                   
                 Myl9 
                 −2.46 
                 −1.24 
                 −2 
                 0 
               
               
                   
                 Mylip 
                 −0.89 
                 −1.04 
                 −0.85 
                 −1.15 
               
               
                   
                 Mylk 
                 −1.6 
                 −1.35 
                 −0.67 
                 −0.98 
               
               
                   
                 Nab2 
                 0.97 
                 1.33 
                 1.59 
                 1.88 
               
               
                   
                 Nalp10 
                 2.35 
                 2.27 
                 1.07 
                 1.35 
               
               
                   
                 Nans 
                 0.49 
                 0.78 
                 1.06 
                 1.83 
               
               
                   
                 Nap1l1 
                 1.01 
                 1.15 
                 0.96 
                 0.42 
               
               
                   
                 Napa 
                 −0.65 
                 −1.04 
                 −0.88 
                 −1.22 
               
               
                   
                 Nasp 
                 1.96 
                 1.81 
                 2.22 
                 1.94 
               
               
                   
                 Nat11 
                 0.75 
                 1.05 
                 0.66 
                 0.19 
               
               
                   
                 Nav1 
                 −1.4 
                 −1.03 
                 −0.96 
                 −0.92 
               
               
                   
                 Nbeal1 
                 0.06 
                 0 
                 0.07 
                 −2.02 
               
               
                   
                 Nbr1 
                 0.29 
                 0.64 
                 −0.41 
                 −1.59 
               
               
                   
                 Ncf1 
                 −1.19 
                 −1.69 
                 −1.74 
                 −2.21 
               
               
                   
                 Ncoa4 /// 
                 1.23 
                 1.33 
                 −0.08 
                 −1.21 
               
               
                   
                 LOC627557 
               
               
                   
                 Nde1 
                 0.85 
                 1.33 
                 0.74 
                 0.55 
               
               
                   
                 Ndn 
                 −2.12 
                 −1.84 
                 −2.09 
                 −4.53 
               
               
                   
                 Ndrg1 
                 0.88 
                 0.63 
                 −0.11 
                 1.26 
               
               
                   
                 Ndrg1 /// Ndrl 
                 1.44 
                 0.69 
                 −0.35 
                 0.39 
               
               
                   
                 Ndrg3 
                 −0.39 
                 −0.24 
                 −0.59 
                 −1.26 
               
               
                   
                 Ndrl 
                 0.99 
                 0.78 
                 −0.04 
                 1.1 
               
               
                   
                 Ndufab1 
                 −1.04 
                 0.05 
                 −0.44 
                 0.21 
               
               
                   
                 Nedd1 
                 0.87 
                 1.64 
                 0.68 
                 0 
               
               
                   
                 Nedd4 
                 0.1 
                 0.27 
                 −0.45 
                 −1.02 
               
               
                   
                 Nedd4l 
                 −0.62 
                 0 
                 −0.29 
                 −2.51 
               
               
                   
                 Nek2 
                 3.62 
                 3.28 
                 4.31 
                 3.02 
               
               
                   
                 Nek3 
                 −1.06 
                 −0.93 
                 −0.98 
                 −1.02 
               
               
                   
                 Nelf 
                 −0.27 
                 0.02 
                 −1.06 
                 0.45 
               
               
                   
                 Net1 
                 0.66 
                 1.1 
                 0.19 
                 −0.67 
               
               
                   
                 Nfat5 
                 −0.2 
                 −0.98 
                 −0.92 
                 −2.56 
               
               
                   
                 Nfia 
                 −0.89 
                 −1.34 
                 −0.28 
                 −0.69 
               
               
                   
                 Nfib 
                 0.07 
                 0.01 
                 0.84 
                 1.32 
               
               
                   
                 Nfix 
                 −1.26 
                 −1.23 
                 −0.82 
                 0.16 
               
               
                   
                 Nfkbia 
                 −0.13 
                 −0.08 
                 0.48 
                 1.19 
               
               
                   
                 Nfkbil2 
                 0.99 
                 0.87 
                 1.13 
                 1.48 
               
               
                   
                 Nfs1 
                 0.68 
                 1 
                 0.08 
                 −0.79 
               
               
                   
                 Ngfrap1 
                 0.73 
                 0.83 
                 0.84 
                 1.25 
               
               
                   
                 Nipa1 
                 −0.87 
                 −0.71 
                 −0.68 
                 −1.05 
               
               
                   
                 Nipsnap1 
                 −0.48 
                 −1.19 
                 −1.1 
                 −0.76 
               
               
                   
                 Nisch 
                 −0.52 
                 −0.97 
                 −0.28 
                 −1.43 
               
               
                   
                 Nlk 
                 −0.13 
                 0 
                 −0.85 
                 −3.12 
               
               
                   
                 Nme4 
                 −1.32 
                 −1.48 
                 −0.4 
                 −0.53 
               
               
                   
                 Nnt 
                 −0.86 
                 −0.89 
                 −1.45 
                 −0.62 
               
               
                   
                 No1l1 
                 0.92 
                 0.57 
                 −0.19 
                 −1 
               
               
                   
                 Nol5 
                 1.11 
                 0.75 
                 1.02 
                 0.99 
               
               
                   
                 Nol5a 
                 0.83 
                 0.5 
                 0.79 
                 1.31 
               
               
                   
                 Nono 
                 −0.39 
                 0 
                 0 
                 −1.8 
               
               
                   
                 Nope 
                 −1.14 
                 −0.5 
                 −1.06 
                 −1.64 
               
               
                   
                 Notch1 
                 −0.94 
                 −1.33 
                 −0.6 
                 −0.32 
               
               
                   
                 Nptn 
                 0.11 
                 0 
                 0.28 
                 −1.48 
               
               
                   
                 Nqo1 
                 −0.63 
                 −1.4 
                 −1.47 
                 −2.21 
               
               
                   
                 Nr2c1 
                 −0.39 
                 0.22 
                 −0.61 
                 −1.58 
               
               
                   
                 Nrarp 
                 −0.43 
                 −0.55 
                 −0.6 
                 −1.19 
               
               
                   
                 Nrip1 
                 −0.23 
                 0 
                 0.19 
                 −2.45 
               
               
                   
                 Nrm 
                 2.3 
                 2.29 
                 2.23 
                 1.61 
               
               
                   
                 Nrtn 
                 −1.35 
                 −0.68 
                 −0.45 
                 −0.17 
               
               
                   
                 Nsg1 
                 1.47 
                 1.24 
                 1.5 
                 2.44 
               
               
                   
                 Nsun4 
                 −0.75 
                 −0.67 
                 −0.05 
                 −1.02 
               
               
                   
                 Nubp1 
                 0.98 
                 1.9 
                 0.1 
                 −0.71 
               
               
                   
                 Nucb2 
                 1.2 
                 0.75 
                 0.68 
                 0.87 
               
               
                   
                 Nucks1 
                 0.28 
                 0.21 
                 0.84 
                 1.17 
               
               
                   
                 Nudcd1 
                 1.03 
                 1.46 
                 0.55 
                 −0.59 
               
               
                   
                 Nudt16 
                 −0.86 
                 −1.26 
                 −0.81 
                 −0.35 
               
               
                   
                 Nup107 
                 1.04 
                 1.07 
                 1.56 
                 1.47 
               
               
                   
                 Nup133 
                 0.73 
                 1.24 
                 0.48 
                 −0.16 
               
               
                   
                 Nup155 
                 1.32 
                 1.02 
                 1.34 
                 0.94 
               
               
                   
                 Nup210 
                 0.36 
                 1.21 
                 1.13 
                 1.53 
               
               
                   
                 Nup35 
                 0.86 
                 1.07 
                 0.78 
                 0.78 
               
               
                   
                 Nup37 
                 0.78 
                 1.03 
                 0.86 
                 1.01 
               
               
                   
                 Nup43 
                 1.11 
                 0.96 
                 0.4 
                 0.63 
               
               
                   
                 Nup54 
                 0.7 
                 1 
                 0.9 
                 1.28 
               
               
                   
                 Nup62 
                 0.77 
                 0.66 
                 1.21 
                 1.68 
               
               
                   
                 Nup85 
                 0.97 
                 0.91 
                 0.42 
                 1.35 
               
               
                   
                 Nupl1 
                 0.98 
                 1.66 
                 0.69 
                 0.16 
               
               
                   
                 Nupr1 
                 0.62 
                 1.3 
                 1.28 
                 2.34 
               
               
                   
                 Nusap1 
                 3.4 
                 3.12 
                 3.7 
                 2.19 
               
               
                   
                 Nxt1 
                 1.11 
                 0.84 
                 0.94 
                 1.07 
               
               
                   
                 Oas1a 
                 0.93 
                 1.89 
                 3.12 
                 3.04 
               
               
                   
                 Oasl2 
                 0 
                 1.16 
                 2.13 
                 4.51 
               
               
                   
                 Odc1 /// 
                 0.83 
                 1.04 
                 0.75 
                 1.1 
               
               
                   
                 LOC639787 /// 
               
               
                   
                 LOC666231 /// 
               
               
                   
                 LOC668343 /// 
               
               
                   
                 LOC670279 /// 
               
               
                   
                 LOC671154 /// 
               
               
                   
                 LOC671973 /// 
               
               
                   
                 LOC673302 
               
               
                   
                 Odc1 /// 
                 0.27 
                 0.43 
                 0.77 
                 1.1 
               
               
                   
                 LOC666231 /// 
               
               
                   
                 LOC668343 /// 
               
               
                   
                 LOC670279 /// 
               
               
                   
                 LOC671973 /// 
               
               
                   
                 LOC673302 
               
               
                   
                 Odz4 
                 2.77 
                 2.46 
                 0 
                 1.61 
               
               
                   
                 Ogt 
                 −0.19 
                 −0.12 
                 −0.42 
                 −2.2 
               
               
                   
                 Oip5 
                 2.78 
                 2.53 
                 1.97 
                 2.24 
               
               
                   
                 Oit1 
                 −0.21 
                 −0.35 
                 −0.39 
                 −1.37 
               
               
                   
                 Olfm1 
                 −1.6 
                 −1.41 
                 −1.75 
                 −1.91 
               
               
                   
                 Opn3 
                 0.39 
                 0.43 
                 1.42 
                 1.94 
               
               
                   
                 Orc1l 
                 4.09 
                 1.46 
                 3.11 
                 2.65 
               
               
                   
                 Orc6l 
                 1.54 
                 1.37 
                 1.51 
                 1.5 
               
               
                   
                 Ormdl3 
                 −0.73 
                 −0.69 
                 −0.79 
                 −1.03 
               
               
                   
                 Osbpl3 
                 −0.93 
                 −1.18 
                 −0.78 
                 −1.5 
               
               
                   
                 Osbpl8 
                 −0.85 
                 −0.51 
                 −1.09 
                 −0.82 
               
               
                   
                 Osmr 
                 −0.46 
                 0.03 
                 −1.08 
                 −2.24 
               
               
                   
                 Ostm1 
                 −0.49 
                 −0.63 
                 −0.6 
                 −1.03 
               
               
                   
                 Otub2 
                 −0.57 
                 −0.67 
                 −0.7 
                 −1.21 
               
               
                   
                 Otud4 
                 0.46 
                 1.25 
                 0.33 
                 −0.59 
               
               
                   
                 P2rx4 
                 −0.96 
                 −1.08 
                 −1.12 
                 −0.44 
               
               
                   
                 Pabpn1 
                 −0.67 
                 −0.91 
                 −0.52 
                 −1.59 
               
               
                   
                 Pacs2 
                 0.22 
                 0.69 
                 1.19 
                 0.78 
               
               
                   
                 Pacsin1 
                 −0.91 
                 −1.33 
                 −0.52 
                 −1.03 
               
               
                   
                 Padi3 
                 0.54 
                 0.71 
                 1.14 
                 0.1 
               
               
                   
                 Pafah1b2 
                 0.69 
                 0.55 
                 −0.29 
                 −1.67 
               
               
                   
                 Pak3 
                 −0.42 
                 −1.38 
                 0.9 
                 −0.5 
               
               
                   
                 Pam 
                 −0.66 
                 −0.69 
                 −1.35 
                 −0.61 
               
               
                   
                 Papola 
                 −0.55 
                 −0.58 
                 −0.45 
                 −1.56 
               
               
                   
                 Paqr3 
                 −1 
                 −0.82 
                 −0.72 
                 −0.84 
               
               
                   
                 Paqr4 
                 0 
                 1.12 
                 2.72 
                 3.02 
               
               
                   
                 Paqr5 
                 −0.2 
                 −0.16 
                 −0.44 
                 −1.33 
               
               
                   
                 Paqr6 
                 −1.72 
                 −1.04 
                 −1.02 
                 −1.31 
               
               
                   
                 Paqr7 
                 −0.98 
                 −1.09 
                 −1.04 
                 −1.1 
               
               
                   
                 Paqr8 
                 −0.11 
                 0.7 
                 1.25 
                 0.7 
               
               
                   
                 Pard3 
                 −0.2 
                 −0.42 
                 −0.83 
                 −1.52 
               
               
                   
                 Pard6b 
                 0.68 
                 1.12 
                 0.79 
                 1.34 
               
               
                   
                 Parp3 
                 −1.82 
                 −1.08 
                 −0.68 
                 −0.76 
               
               
                   
                 Parp4 
                 −0.86 
                 −1.02 
                 −0.42 
                 −0.24 
               
               
                   
                 Pask 
                 1.55 
                 1.14 
                 3.98 
                 1.91 
               
               
                   
                 Paxip1 
                 0.85 
                 0.09 
                 1.33 
                 0.95 
               
               
                   
                 Pbk 
                 3.45 
                 3.62 
                 4.48 
                 2.76 
               
               
                   
                 Pbx1 
                 −0.03 
                 −0.57 
                 −1.06 
                 −2.25 
               
               
                   
                 Pbx3 
                 0.81 
                 0.88 
                 1.33 
                 1.78 
               
               
                   
                 Pcaf 
                 −0.54 
                 0 
                 0.02 
                 −1.31 
               
               
                   
                 Pcdhgc3 
                 −0.16 
                 0 
                 −0.38 
                 −2.09 
               
               
                   
                 Pcgf3 
                 0.06 
                 0 
                 0.12 
                 −2.29 
               
               
                   
                 Pcgf6 
                 −0.68 
                 −1.36 
                 −0.91 
                 −2.14 
               
               
                   
                 Pcmt1 
                 1.31 
                 0.69 
                 1.31 
                 1.68 
               
               
                   
                 Pcmtd1 
                 −0.42 
                 −0.15 
                 −0.36 
                 −1.01 
               
               
                   
                 Pcmtd2 
                 −0.21 
                 −0.18 
                 −0.38 
                 −1.04 
               
               
                   
                 Pcna 
                 1.37 
                 1.43 
                 1.43 
                 1.52 
               
               
                   
                 Pcnt 
                 0.59 
                 2.21 
                 0.85 
                 −0.36 
               
               
                   
                 Pcolce 
                 −1.48 
                 −1.26 
                 −0.7 
                 −0.94 
               
               
                   
                 Pctp 
                 −0.86 
                 −0.68 
                 −0.81 
                 −1 
               
               
                   
                 Pcyox1 
                 −0.65 
                 −0.4 
                 −0.58 
                 −1.11 
               
               
                   
                 Pdap1 
                 0.31 
                 −0.35 
                 0.47 
                 1.23 
               
               
                   
                 Pdcd6ip 
                 0.87 
                 1.79 
                 −0.05 
                 −0.88 
               
               
                   
                 Pde2a 
                 −0.7 
                 −1.09 
                 −0.38 
                 0.09 
               
               
                   
                 Pde7a 
                 1.06 
                 1.1 
                 0.89 
                 −0.65 
               
               
                   
                 Pdgfra 
                 −2.13 
                 −2.12 
                 0 
                 0 
               
               
                   
                 Pdha1 
                 −0.14 
                 −0.03 
                 −0.65 
                 −1.43 
               
               
                   
                 Pdik1l 
                 0.77 
                 2.93 
                 0.83 
                 −0.23 
               
               
                   
                 Pdk4 
                 −0.29 
                 −0.31 
                 −1.03 
                 −1.13 
               
               
                   
                 Pdlim1 
                 0.59 
                 0.56 
                 0.9 
                 1.04 
               
               
                   
                 Pdlim5 
                 0.96 
                 0 
                 0.64 
                 −1.76 
               
               
                   
                 Pdxk 
                 −1.05 
                 −1.13 
                 −0.63 
                 −0.5 
               
               
                   
                 Pdzd2 
                 −0.63 
                 −0.51 
                 −0.63 
                 −1.16 
               
               
                   
                 Pdzrn3 
                 −2.11 
                 −1.05 
                 −0.47 
                 −0.55 
               
               
                   
                 Peg3 
                 0.31 
                 0.3 
                 −0.15 
                 −1.84 
               
               
                   
                 Peli1 
                 0.57 
                 0.75 
                 −0.89 
                 −2.5 
               
               
                   
                 Pex12 
                 −0.56 
                 −0.28 
                 −0.88 
                 −1.06 
               
               
                   
                 Pex3 
                 −0.19 
                 −0.3 
                 −0.43 
                 −1.27 
               
               
                   
                 Pfdn4 
                 0.67 
                 0.31 
                 0.68 
                 1.19 
               
               
                   
                 Pfdn5 
                 −0.38 
                 −0.41 
                 −0.79 
                 −1.17 
               
               
                   
                 Pfkfb3 
                 2.17 
                 1.5 
                 0 
                 0 
               
               
                   
                 Pfkfb4 
                 −1.46 
                 −1.35 
                 −0.49 
                 −1.27 
               
               
                   
                 Pfkm 
                 −0.9 
                 −0.76 
                 −0.85 
                 −1.03 
               
               
                   
                 Pfkp 
                 1.85 
                 1.55 
                 0.94 
                 2.16 
               
               
                   
                 Pftk1 
                 −1.06 
                 −0.53 
                 0.29 
                 0.31 
               
               
                   
                 Pgcp 
                 −2.61 
                 −2.46 
                 −1.97 
                 −2.71 
               
               
                   
                 Pgk1 /// 
                 2.45 
                 1.56 
                 0.34 
                 2.48 
               
               
                   
                 LOC433594 /// 
               
               
                   
                 LOC665053 /// 
               
               
                   
                 LOC668435 
               
               
                   
                 Pgk1 /// 
                 1.32 
                 1.1 
                 0.5 
                 1.27 
               
               
                   
                 LOC433594 /// 
               
               
                   
                 LOC668435 
               
               
                   
                 Phactr4 
                 0.57 
                 0.56 
                 0.56 
                 1.09 
               
               
                   
                 Phf10 
                 0.52 
                 1.02 
                 0.75 
                 0.98 
               
               
                   
                 Phf13 
                 0.11 
                 0.04 
                 0.41 
                 1.01 
               
               
                   
                 Phf14 
                 −0.09 
                 0 
                 −0.32 
                 −1.77 
               
               
                   
                 Phf15 
                 −0.94 
                 −0.92 
                 −1.04 
                 −0.84 
               
               
                   
                 Phf17 
                 0.47 
                 1.13 
                 0.44 
                 0.01 
               
               
                   
                 Phf20l1 
                 0.3 
                 −0.53 
                 −0.36 
                 −1.64 
               
               
                   
                 Phf6 
                 0.83 
                 1.16 
                 0.34 
                 −0.34 
               
               
                   
                 Phgdh /// 
                 1.02 
                 0.47 
                 0.67 
                 0.59 
               
               
                   
                 LOC666422 /// 
               
               
                   
                 LOC666875 /// 
               
               
                   
                 LOC669985 /// 
               
               
                   
                 LOC671102 /// 
               
               
                   
                 LOC673015 /// 
               
               
                   
                 LOC675010 
               
               
                   
                 Phgdh /// 
                 0.56 
                 0.07 
                 0.59 
                 1.41 
               
               
                   
                 LOC668771 /// 
               
               
                   
                 LOC670155 /// 
               
               
                   
                 LOC671972 /// 
               
               
                   
                 LOC673015 
               
               
                   
                 Phgdh /// 
                 0.41 
                 −0.03 
                 0.51 
                 1.58 
               
               
                   
                 LOC668771 /// 
               
               
                   
                 LOC671972 /// 
               
               
                   
                 LOC673015 
               
               
                   
                 Phkb 
                 −0.93 
                 −1.05 
                 −1.2 
                 −0.98 
               
               
                   
                 Phtf2 
                 −1.04 
                 −0.71 
                 −0.93 
                 −0.97 
               
               
                   
                 Pi16 
                 −1.75 
                 −3.63 
                 −1.65 
                 0 
               
               
                   
                 Pi4k2b 
                 1.03 
                 0.8 
                 0.31 
                 −0.12 
               
               
                   
                 Piga 
                 1.49 
                 0.8 
                 1.33 
                 0.35 
               
               
                   
                 Pigr 
                 −1.33 
                 −0.27 
                 1.35 
                 1.68 
               
               
                   
                 Pik3ap1 
                 −1.08 
                 0 
                 0 
                 1.51 
               
               
                   
                 Pik3r1 
                 −0.5 
                 −0.3 
                 −0.85 
                 −2.84 
               
               
                   
                 Pik4ca 
                 −0.8 
                 −1.03 
                 −0.6 
                 −0.79 
               
               
                   
                 Pim1 
                 0.41 
                 0.87 
                 0.56 
                 1.47 
               
               
                   
                 Pim3 
                 −0.14 
                 0.18 
                 0.45 
                 1.11 
               
               
                   
                 Pip5k2c 
                 0.2 
                 0.4 
                 −0.07 
                 −1.25 
               
               
                   
                 Pitpnb 
                 0.93 
                 1.16 
                 −0.26 
                 −1.3 
               
               
                   
                 Pkd2 
                 −0.84 
                 −0.7 
                 −1.06 
                 −0.31 
               
               
                   
                 Pkhd1 
                 −1.19 
                 −0.99 
                 −0.57 
                 −0.46 
               
               
                   
                 Pkmyt1 
                 2.38 
                 1.58 
                 1.57 
                 1.8 
               
               
                   
                 Pkp1 
                 0.42 
                 0.84 
                 1.22 
                 1.09 
               
               
                   
                 Pkp2 
                 0.59 
                 0.5 
                 0.58 
                 1.04 
               
               
                   
                 Pkp3 
                 0.53 
                 1.19 
                 0.04 
                 −0.57 
               
               
                   
                 Pla2g6 
                 −0.86 
                 −0.48 
                 −0.88 
                 −1.14 
               
               
                   
                 Pla2g7 
                 −1.07 
                 −1.07 
                 −1.37 
                 −2.89 
               
               
                   
                 Pla2r1 
                 −1.45 
                 −1.08 
                 −0.21 
                 −0.8 
               
               
                   
                 Plac1 
                 0 
                 0 
                 0 
                 2.42 
               
               
                   
                 Plac8 
                 −0.66 
                 −0.68 
                 −1 
                 1.13 
               
               
                   
                 Plau 
                 −1.5 
                 −1.99 
                 −1.49 
                 −1.7 
               
               
                   
                 Plaur 
                 1.76 
                 1.73 
                 1.15 
                 1.12 
               
               
                   
                 Plce1 
                 −1.01 
                 −0.69 
                 −0.62 
                 −0.71 
               
               
                   
                 Plch1 
                 2.97 
                 1.2 
                 2.2 
                 0.79 
               
               
                   
                 Pld1 
                 −0.48 
                 −0.83 
                 −0.75 
                 −1.31 
               
               
                   
                 Pldn 
                 0.39 
                 0.83 
                 −0.45 
                 −1.47 
               
               
                   
                 Plekha2 
                 0.83 
                 1.05 
                 −0.05 
                 −0.35 
               
               
                   
                 Plekha8 
                 0.84 
                 0.47 
                 0.95 
                 1.34 
               
               
                   
                 Plekhb1 
                 −2.08 
                 −2.59 
                 −2.86 
                 −2.26 
               
               
                   
                 Plekhc1 
                 −1.28 
                 −1.24 
                 −0.74 
                 −0.83 
               
               
                   
                 Plekhf2 
                 0.66 
                 1.53 
                 0.45 
                 −0.16 
               
               
                   
                 Plekhg2 
                 0.4 
                 0.36 
                 0.48 
                 1.16 
               
               
                   
                 Plk1 
                 3 
                 3.84 
                 2.85 
                 2 
               
               
                   
                 Plk2 
                 0.47 
                 0.57 
                 1.01 
                 1.65 
               
               
                   
                 Plk4 
                 3.09 
                 4.9 
                 2.87 
                 2.49 
               
               
                   
                 Pls3 
                 −0.67 
                 −0.68 
                 −1.12 
                 −0.96 
               
               
                   
                 Plscr1 
                 1.48 
                 1.36 
                 0.42 
                 1.91 
               
               
                   
                 Plscr1 /// 
                 1.16 
                 0 
                 0.75 
                 1.59 
               
               
                   
                 LOC433328 /// 
               
               
                   
                 LOC677340 
               
               
                   
                 Pltp 
                 −0.65 
                 −1.05 
                 −1.21 
                 −2.38 
               
               
                   
                 Plvap 
                 −0.17 
                 0.13 
                 0.79 
                 1.92 
               
               
                   
                 Pmaip1 
                 1.66 
                 1.87 
                 1.35 
                 1.92 
               
               
                   
                 Pmf1 
                 1.88 
                 0.53 
                 0.53 
                 1.52 
               
               
                   
                 Pmm2 
                 0.4 
                 1.06 
                 −0.11 
                 −1.72 
               
               
                   
                 Pmp22 
                 −1.59 
                 −0.78 
                 −1.14 
                 0 
               
               
                   
                 Pms1 
                 0.82 
                 1.05 
                 0.9 
                 0.8 
               
               
                   
                 Pms2 
                 0.96 
                 0.96 
                 1.14 
                 0.85 
               
               
                   
                 Pnn 
                 0.73 
                 1.44 
                 0.18 
                 −1.71 
               
               
                   
                 Pola1 
                 2.24 
                 2.12 
                 2.21 
                 1.41 
               
               
                   
                 Pola2 
                 1.66 
                 1.72 
                 1.24 
                 1.42 
               
               
                   
                 Polb 
                 −0.08 
                 0 
                 −0.32 
                 −3.11 
               
               
                   
                 Pold1 
                 1.75 
                 1.7 
                 1.45 
                 2.32 
               
               
                   
                 Pold2 
                 0.96 
                 1.12 
                 0.81 
                 1.32 
               
               
                   
                 Pold3 
                 1.18 
                 0.84 
                 0.47 
                 0.16 
               
               
                   
                 Pole 
                 3.75 
                 3.12 
                 5.21 
                 1.84 
               
               
                   
                 Pole2 
                 1.88 
                 1.71 
                 2.18 
                 1.68 
               
               
                   
                 Pole3 
                 1.08 
                 1.25 
                 0.83 
                 0.5 
               
               
                   
                 Polg 
                 0.11 
                 0.69 
                 0.85 
                 1.24 
               
               
                   
                 Polr3c 
                 0.61 
                 0.83 
                 −0.25 
                 −1.11 
               
               
                   
                 Pon3 
                 1.18 
                 1.3 
                 0.87 
                 0.89 
               
               
                   
                 Postn 
                 −1.44 
                 0 
                 −2.09 
                 0 
               
               
                   
                 Ppap2b 
                 −0.94 
                 −1.3 
                 −0.72 
                 −1.29 
               
               
                   
                 Ppara 
                 −0.52 
                 −0.99 
                 −1.09 
                 −1.17 
               
               
                   
                 Ppfibp2 
                 −0.27 
                 −0.26 
                 −0.48 
                 −1.03 
               
               
                   
                 Ppih /// 
                 1.05 
                 0.38 
                 1 
                 0.71 
               
               
                   
                 LOC433064 /// 
               
               
                   
                 LOC624822 /// 
               
               
                   
                 LOC629952 /// 
               
               
                   
                 LOC665989 /// 
               
               
                   
                 LOC666411 /// 
               
               
                   
                 LOC667598 /// 
               
               
                   
                 LOC669441 /// 
               
               
                   
                 LOC670964 /// 
               
               
                   
                 LOC671009 /// 
               
               
                   
                 LOC676493 
               
               
                   
                 Ppih /// 
                 1.07 
                 0.98 
                 1.34 
                 1.21 
               
               
                   
                 LOC433064 /// 
               
               
                   
                 LOC624822 /// 
               
               
                   
                 LOC665989 /// 
               
               
                   
                 LOC667598 /// 
               
               
                   
                 LOC669441 /// 
               
               
                   
                 LOC670964 /// 
               
               
                   
                 LOC676493 
               
               
                   
                 Ppih /// 
                 1.12 
                 1.05 
                 1.41 
                 1.16 
               
               
                   
                 LOC433064 /// 
               
               
                   
                 LOC629952 /// 
               
               
                   
                 LOC665989 /// 
               
               
                   
                 LOC666411 /// 
               
               
                   
                 LOC669441 /// 
               
               
                   
                 LOC671009 /// 
               
               
                   
                 LOC676493 
               
               
                   
                 Ppil1 
                 0.86 
                 1.03 
                 0.83 
                 0.59 
               
               
                   
                 Ppil5 
                 5.43 
                 5.81 
                 4.42 
                 3.32 
               
               
                   
                 Ppm1b 
                 0.69 
                 1.3 
                 0.36 
                 0.2 
               
               
                   
                 Ppm1h 
                 −0.6 
                 −0.82 
                 −1.02 
                 −0.94 
               
               
                   
                 Ppm11 
                 −1.07 
                 −0.25 
                 −0.02 
                 −0.34 
               
               
                   
                 Ppm1m 
                 −0.19 
                 0.17 
                 0.26 
                 1.27 
               
               
                   
                 Ppp1r12a 
                 0.46 
                 1.01 
                 −0.12 
                 −1.58 
               
               
                   
                 Ppp1r12b 
                 −1.35 
                 −0.99 
                 −0.78 
                 −1.87 
               
               
                   
                 Ppp1r2 
                 0.83 
                 1.08 
                 0.41 
                 0.03 
               
               
                   
                 Ppp1r8 
                 0.52 
                 0.71 
                 0.59 
                 1.3 
               
               
                   
                 Ppp2r5e 
                 −0.06 
                 0 
                 0.13 
                 −2.43 
               
               
                   
                 Prc1 
                 3.97 
                 3.03 
                 3.78 
                 1.98 
               
               
                   
                 Prdm4 
                 0.19 
                 0.37 
                 0.14 
                 1.02 
               
               
                   
                 Prdx4 
                 1.21 
                 1.62 
                 1.22 
                 1.9 
               
               
                   
                 Prim1 
                 3.12 
                 2.9 
                 2.6 
                 2.06 
               
               
                   
                 Prim2 
                 1.96 
                 2.55 
                 1.84 
                 1.68 
               
               
                   
                 Prkar2a 
                 0.28 
                 0.05 
                 0.75 
                 1.07 
               
               
                   
                 Prkar2b 
                 1.2 
                 1.39 
                 0.48 
                 −0.13 
               
               
                   
                 Prkch 
                 0.02 
                 0.26 
                 0.19 
                 −1.04 
               
               
                   
                 Prkci 
                 1.25 
                 2.18 
                 0.44 
                 −0.78 
               
               
                   
                 Procr 
                 −0.81 
                 −0.97 
                 −1.03 
                 −0.52 
               
               
                   
                 Prodh /// 
                 −1.02 
                 −1.4 
                 −1.01 
                 −1.53 
               
               
                   
                 LOC671160 
               
               
                   
                 Prom2 
                 −0.09 
                 −0.05 
                 −1.13 
                 −2.19 
               
               
                   
                 Prpf3 
                 0.49 
                 0.26 
                 0.84 
                 1.47 
               
               
                   
                 Prpf4b 
                 0.48 
                 0.45 
                 0.05 
                 −1.01 
               
               
                   
                 Prps1 /// 
                 0.84 
                 1.02 
                 0.25 
                 −0.46 
               
               
                   
                 AU021838 
               
               
                   
                 Prss15 
                 1.04 
                 0.99 
                 0.5 
                 0.87 
               
               
                   
                 Prss23 
                 −0.95 
                 0 
                 −1.42 
                 0.58 
               
               
                   
                 Prss27 
                 0.36 
                 0.15 
                 1.26 
                 1.17 
               
               
                   
                 Psap 
                 −0.4 
                 −0.1 
                 −0.46 
                 −1.42 
               
               
                   
                 Psat1 
                 1.77 
                 1.44 
                 1.22 
                 0.82 
               
               
                   
                 Psca 
                 −1.12 
                 −0.88 
                 −0.86 
                 −1.32 
               
               
                   
                 Psen1 
                 0.07 
                 0.35 
                 −0.08 
                 −1.15 
               
               
                   
                 Psip1 
                 0.71 
                 1.04 
                 1.21 
                 0.99 
               
               
                   
                 Psmb9 
                 0.04 
                 0.6 
                 0.87 
                 1.43 
               
               
                   
                 Psme4 
                 0.51 
                 0.54 
                 −0.53 
                 −1.23 
               
               
                   
                 Psrc1 
                 1.33 
                 3.21 
                 1.91 
                 1.33 
               
               
                   
                 Pstpip2 
                 1.16 
                 0.78 
                 1.1 
                 0.5 
               
               
                   
                 Ptbp2 
                 0.19 
                 0 
                 −0.19 
                 −3.49 
               
               
                   
                 Ptdsr 
                 1.32 
                 1.33 
                 0.05 
                 0.75 
               
               
                   
                 Ptk9 
                 0.38 
                 0.78 
                 −0.39 
                 −1.43 
               
               
                   
                 Ptk9l 
                 −0.06 
                 0.14 
                 0.66 
                 1.03 
               
               
                   
                 Ptov1 
                 −0.51 
                 −0.55 
                 0.74 
                 1.14 
               
               
                   
                 Ptp4a1 
                 −0.08 
                 0.64 
                 −0.24 
                 −1.04 
               
               
                   
                 Ptp4a2 
                 −0.58 
                 −0.83 
                 0.34 
                 1.06 
               
               
                   
                 Ptplad1 
                 −0.24 
                 0.84 
                 −0.22 
                 −1.57 
               
               
                   
                 Ptplb 
                 −1.15 
                 −1.32 
                 −1.4 
                 −2.01 
               
               
                   
                 Ptprb 
                 −0.58 
                 −1.29 
                 0 
                 0 
               
               
                   
                 Ptpre 
                 −1.26 
                 −1.39 
                 −0.96 
                 −1.73 
               
               
                   
                 Ptprf 
                 0.09 
                 0.15 
                 0 
                 −1.21 
               
               
                   
                 Ptprj 
                 0.51 
                 0.62 
                 0.95 
                 1.32 
               
               
                   
                 Ptprr 
                 0.51 
                 1.03 
                 0.38 
                 −0.26 
               
               
                   
                 Ptpru 
                 −1 
                 −1.45 
                 −1.3 
                 −1.2 
               
               
                   
                 Pttg1 
                 1.72 
                 1.48 
                 1.52 
                 1.19 
               
               
                   
                 Pvrl2 
                 0.79 
                 0.59 
                 0.67 
                 1.05 
               
               
                   
                 Pvrl3 
                 −1.08 
                 −1.5 
                 −0.53 
                 −2.08 
               
               
                   
                 Rab10 
                 −0.41 
                 −0.68 
                 −0.66 
                 −1.25 
               
               
                   
                 Rab14 
                 0.24 
                 0 
                 0.15 
                 −2.66 
               
               
                   
                 Rab17 
                 0 
                 0 
                 0.43 
                 1.8 
               
               
                   
                 Rab18 
                 0.28 
                 0.7 
                 −0.64 
                 −2.13 
               
               
                   
                 Rab27a 
                 −0.86 
                 −0.53 
                 −1.1 
                 −1.35 
               
               
                   
                 Rab27b 
                 −0.34 
                 −0.11 
                 −0.76 
                 −2.03 
               
               
                   
                 Rab3b 
                 1.8 
                 0.64 
                 1.13 
                 1.06 
               
               
                   
                 Rab6ip2 
                 0.71 
                 0.76 
                 0.67 
                 1.1 
               
               
                   
                 Racgap1 
                 5.85 
                 2.66 
                 5.49 
                 2.77 
               
               
                   
                 Rad18 
                 1.84 
                 1.19 
                 1.56 
                 1.04 
               
               
                   
                 Rad21 
                 1.07 
                 1.54 
                 0.85 
                 −0.24 
               
               
                   
                 Rad23a 
                 0.61 
                 1.09 
                 −0.22 
                 −0.45 
               
               
                   
                 Rad51 
                 3.62 
                 5.06 
                 4.32 
                 2.72 
               
               
                   
                 Rad51ap1 
                 2.9 
                 5.41 
                 4.8 
                 2.85 
               
               
                   
                 Rad54l 
                 2.1 
                 2.72 
                 2.29 
                 2.53 
               
               
                   
                 Rai14 
                 −0.25 
                 0 
                 −0.88 
                 −4.65 
               
               
                   
                 Ranbp1 
                 1.13 
                 0.89 
                 0.94 
                 0.84 
               
               
                   
                 Rangap1 
                 0.94 
                 1.19 
                 0.53 
                 −0.18 
               
               
                   
                 Rap2c 
                 0.29 
                 0.29 
                 0.64 
                 1.33 
               
               
                   
                 Rarg 
                 0.15 
                 1.01 
                 0.32 
                 −0.71 
               
               
                   
                 Rarres2 
                 −1.38 
                 −0.92 
                 −2.06 
                 0 
               
               
                   
                 Rasa3 
                 −0.66 
                 −1.17 
                 −0.82 
                 −0.74 
               
               
                   
                 Rasgrp1 
                 0 
                 0 
                 0 
                 1.65 
               
               
                   
                 Rasl11b 
                 −1.43 
                 −1.43 
                 −1.32 
                 −1.73 
               
               
                   
                 Rassf1 
                 0.31 
                 0.48 
                 0.45 
                 1.06 
               
               
                   
                 Rassf3 
                 −1.15 
                 −0.74 
                 −0.28 
                 −0.29 
               
               
                   
                 Rbbp4 
                 0.54 
                 1.35 
                 0.43 
                 −0.99 
               
               
                   
                 Rbl1 
                 1.4 
                 1.46 
                 1.31 
                 1.57 
               
               
                   
                 Rbl2 /// 
                 −0.45 
                 −0.1 
                 −0.87 
                 −1.39 
               
               
                   
                 LOC635075 
               
               
                   
                 Rbm14 
                 0.61 
                 0.06 
                 0.36 
                 1.12 
               
               
                   
                 Rbm5 
                 −0.46 
                 −1.53 
                 −0.31 
                 −1.36 
               
               
                   
                 Rbm6 
                 0.25 
                 0.27 
                 0.04 
                 −1.2 
               
               
                   
                 Rbm8a 
                 0.45 
                 0.41 
                 0.7 
                 1.31 
               
               
                   
                 Rbms1 
                 −0.26 
                 0 
                 −0.58 
                 −1.48 
               
               
                   
                 Rbms3 
                 −0.64 
                 0 
                 −0.59 
                 −3.37 
               
               
                   
                 Rbmx 
                 −0.72 
                 −0.25 
                 −0.31 
                 −1.52 
               
               
                   
                 Rbp1 
                 0.38 
                 1.61 
                 1.02 
                 1.82 
               
               
                   
                 Rcbtb2 
                 −0.54 
                 −0.13 
                 −0.67 
                 −1.42 
               
               
                   
                 Rcc1 
                 0.89 
                 1.16 
                 1.52 
                 1.93 
               
               
                   
                 Rdbp 
                 0.43 
                 0.37 
                 0.47 
                 1 
               
               
                   
                 Rdx 
                 0.86 
                 1.08 
                 1.81 
                 1.69 
               
               
                   
                 Reep5 
                 −0.99 
                 −0.68 
                 −0.77 
                 −1.19 
               
               
                   
                 Reep6 
                 −0.84 
                 −0.78 
                 −1.03 
                 −1.71 
               
               
                   
                 Rfc2 
                 1.06 
                 0.57 
                 1.12 
                 1.62 
               
               
                   
                 Rfc3 
                 1.45 
                 1.71 
                 0.81 
                 0.11 
               
               
                   
                 Rfc4 
                 2.03 
                 2.37 
                 1.68 
                 1.64 
               
               
                   
                 Rfc5 
                 1.64 
                 1.54 
                 1.65 
                 1.25 
               
               
                   
                 Rgnef 
                 −0.97 
                 −0.74 
                 −0.71 
                 −1.38 
               
               
                   
                 Rgs10 
                 1.4 
                 0.5 
                 0.15 
                 0.83 
               
               
                   
                 Rgs11 
                 −0.86 
                 −0.46 
                 −1.07 
                 −1.22 
               
               
                   
                 Rgs2 
                 −2.47 
                 0 
                 −0.98 
                 0 
               
               
                   
                 Rgs5 
                 −1.53 
                 −2.8 
                 −2.53 
                 −2.46 
               
               
                   
                 Rhoc 
                 −0.22 
                 0.03 
                 0.66 
                 1.53 
               
               
                   
                 Rhoq 
                 −1.56 
                 −1.36 
                 −0.86 
                 −1.12 
               
               
                   
                 Rhou 
                 −0.04 
                 0.12 
                 0.6 
                 1.29 
               
               
                   
                 Rhpn2 
                 −1.31 
                 −1.2 
                 −0.13 
                 0.03 
               
               
                   
                 Rian 
                 −1.21 
                 −3.35 
                 −1.81 
                 −2.66 
               
               
                   
                 Rin1 
                 −0.19 
                 −0.19 
                 −0.57 
                 −1.04 
               
               
                   
                 Ripk3 
                 1.68 
                 2.32 
                 1.45 
                 1.5 
               
               
                   
                 Rnase4 
                 −0.22 
                 −0.09 
                 −0.57 
                 −1.08 
               
               
                   
                 Rnd3 
                 1.73 
                 0.96 
                 0.11 
                 0 
               
               
                   
                 Rnf125 
                 −1.53 
                 −1.11 
                 −1.7 
                 −1.49 
               
               
                   
                 Rnf13 
                 0.3 
                 0.89 
                 −0.18 
                 −1.33 
               
               
                   
                 Rnf14 
                 0.16 
                 0.43 
                 −0.3 
                 −1.11 
               
               
                   
                 Rnf186 
                 1.68 
                 1.17 
                 1.3 
                 0 
               
               
                   
                 Rnf19 
                 0.85 
                 1.03 
                 0.46 
                 0.26 
               
               
                   
                 Rnf26 /// 
                 0.91 
                 1.09 
                 1.18 
                 1.17 
               
               
                   
                 LOC668155 /// 
               
               
                   
                 LOC669536 
               
               
                   
                 Rnf39 
                 0.71 
                 1.27 
                 1.45 
                 1.57 
               
               
                   
                 Rnpc2 
                 0.93 
                 1.42 
                 0.24 
                 −1.03 
               
               
                   
                 Rnps1 
                 0.61 
                 0.42 
                 0.75 
                 1.12 
               
               
                   
                 Rod1 
                 1.1 
                 1.52 
                 1.1 
                 0.36 
               
               
                   
                 RP23-136K12.4 
                 −0.12 
                 0.06 
                 −0.73 
                 −1.13 
               
               
                   
                 Rpa1 
                 0.9 
                 1.16 
                 0.87 
                 0.69 
               
               
                   
                 Rpa2 
                 2.23 
                 3.31 
                 1.94 
                 0.93 
               
               
                   
                 Rpa3 
                 0.89 
                 0.82 
                 1.1 
                 1.6 
               
               
                   
                 Rpl37a /// 
                 0.41 
                 1.64 
                 0.31 
                 −0.45 
               
               
                   
                 LOC629949 /// 
               
               
                   
                 LOC640991 /// 
               
               
                   
                 LOC668935 /// 
               
               
                   
                 LOC674834 
               
               
                   
                 Rpp25 
                 0.81 
                 3.32 
                 2.3 
                 1.67 
               
               
                   
                 Rpp30 
                 1.22 
                 1.04 
                 1.04 
                 0.92 
               
               
                   
                 Rps10 /// 
                 0.01 
                 −1.46 
                 −1.08 
                 −0.71 
               
               
                   
                 LOC621772 /// 
               
               
                   
                 LOC636539 /// 
               
               
                   
                 LOC666274 /// 
               
               
                   
                 LOC668457 
               
               
                   
                 Rps12 /// 
                 −0.18 
                 −1.01 
                 −0.82 
                 −0.84 
               
               
                   
                 LOC432865 /// 
               
               
                   
                 LOC627835 /// 
               
               
                   
                 LOC668354 /// 
               
               
                   
                 LOC670751 /// 
               
               
                   
                 LOC670832 /// 
               
               
                   
                 LOC671641 /// 
               
               
                   
                 LOC672008 /// 
               
               
                   
                 LOC672415 /// 
               
               
                   
                 LOC676277 
               
               
                   
                 Rps24 
                 −1.05 
                 −1.03 
                 −1.08 
                 −2.81 
               
               
                   
                 Rrm1 
                 2.25 
                 2.64 
                 1.83 
                 0.35 
               
               
                   
                 Rrm2 
                 3.85 
                 3.41 
                 2.79 
                 1.49 
               
               
                   
                 Rrm2b 
                 −0.31 
                 −0.04 
                 −0.59 
                 −1.98 
               
               
                   
                 Rsad1 
                 −1.06 
                 −0.85 
                 −0.73 
                 −0.95 
               
               
                   
                 Rsad2 
                 0.15 
                 1.19 
                 1.02 
                 3.07 
               
               
                   
                 Rshl3 
                 −2.92 
                 −2.78 
                 −2.44 
                 −2.72 
               
               
                   
                 Rtel1 
                 1.05 
                 0.72 
                 0.9 
                 0.62 
               
               
                   
                 Rtn4 
                 0.3 
                 −1.07 
                 −0.33 
                 −2.24 
               
               
                   
                 Rtn4rl1 
                 −1.12 
                 −0.62 
                 −0.58 
                 −0.72 
               
               
                   
                 Rtp4 
                 0.32 
                 1.97 
                 2.8 
                 2.67 
               
               
                   
                 Rufy3 
                 −0.5 
                 0 
                 −0.47 
                 −2.38 
               
               
                   
                 Runx1 
                 0.11 
                 0.25 
                 −0.21 
                 −1.83 
               
               
                   
                 Rusc1 
                 −0.83 
                 −0.12 
                 −1.17 
                 −1.15 
               
               
                   
                 Ruvbl2 
                 1.01 
                 0.94 
                 0.77 
                 0.96 
               
               
                   
                 S100a1 
                 −0.93 
                 −1.12 
                 −0.84 
                 −0.78 
               
               
                   
                 S100a10 
                 0.84 
                 0.5 
                 0.8 
                 1.1 
               
               
                   
                 S100a14 
                 1.08 
                 1.22 
                 1 
                 1.37 
               
               
                   
                 S100a5 
                 0.63 
                 0.58 
                 1.1 
                 1.2 
               
               
                   
                 S3-12 
                 −1.23 
                 −1.33 
                 −1.35 
                 −0.95 
               
               
                   
                 Samhd1 
                 0.13 
                 0.47 
                 0.3 
                 1.27 
               
               
                   
                 Saps3 
                 −0.15 
                 −0.11 
                 −0.31 
                 −1.19 
               
               
                   
                 Sass6 
                 1.77 
                 2.21 
                 1.63 
                 1.24 
               
               
                   
                 Satb1 
                 −0.35 
                 −0.62 
                 −0.7 
                 −1.07 
               
               
                   
                 Sbk1 
                 −0.77 
                 0.64 
                 0 
                 1.37 
               
               
                   
                 Sbsn 
                 1.26 
                 0.59 
                 0.28 
                 0.75 
               
               
                   
                 Scamp1 
                 0.29 
                 0.42 
                 −0.56 
                 −1.45 
               
               
                   
                 Scara3 
                 0.46 
                 0 
                 1.38 
                 1.51 
               
               
                   
                 Sccpdh 
                 −0.92 
                 −1.29 
                 −0.94 
                 −0.84 
               
               
                   
                 Scd2 
                 0.47 
                 0.67 
                 −0.41 
                 −2.34 
               
               
                   
                 Sco1 
                 −0.47 
                 −0.43 
                 −0.94 
                 −1.01 
               
               
                   
                 Scoc 
                 −0.19 
                 0.66 
                 −0.69 
                 −1.24 
               
               
                   
                 Scube2 
                 −2.41 
                 −2.34 
                 −1.91 
                 −2.53 
               
               
                   
                 Scyl2 
                 0.2 
                 1.06 
                 0.28 
                 −0.14 
               
               
                   
                 Sdc1 
                 0.38 
                 0.83 
                 −0.62 
                 −2.36 
               
               
                   
                 Sdc2 
                 −2.05 
                 −1.64 
                 −1.75 
                 −1.77 
               
               
                   
                 Sdc4 
                 −0.54 
                 −1 
                 −0.1 
                 1.08 
               
               
                   
                 Sdf4 
                 −1.31 
                 −1.4 
                 −0.68 
                 −0.79 
               
               
                   
                 Sdpr 
                 −1.74 
                 −1.28 
                 −1.62 
                 0 
               
               
                   
                 Sec61a1 
                 0.54 
                 1.03 
                 −0.27 
                 −1.58 
               
               
                   
                 Sec63 
                 0.07 
                 0.13 
                 −0.39 
                 −1.23 
               
               
                   
                 Seh1l 
                 0.98 
                 1.32 
                 0.51 
                 0.21 
               
               
                   
                 Sele 
                 −0.67 
                 −0.36 
                 −0.33 
                 −1.73 
               
               
                   
                 Selk 
                 −0.24 
                 0.02 
                 −0.33 
                 −1.06 
               
               
                   
                 Selm 
                 −1.27 
                 −1.12 
                 −0.34 
                 0.34 
               
               
                   
                 Sema3b 
                 −1.33 
                 −0.99 
                 −1.28 
                 −1.98 
               
               
                   
                 Sema3e 
                 0.32 
                 −0.23 
                 −1.01 
                 −0.36 
               
               
                   
                 Sema4c 
                 −1.11 
                 −1.31 
                 −1.24 
                 −1.4 
               
               
                   
                 Sema4g 
                 −1.16 
                 −1.64 
                 −2.14 
                 −1.95 
               
               
                   
                 Senp8 
                 −0.15 
                 −0.24 
                 −0.31 
                 −1.04 
               
               
                   
                 Sephs1 
                 0.84 
                 1.29 
                 0.71 
                 0.08 
               
               
                   
                 Serinc1 
                 0.02 
                 0.32 
                 −0.64 
                 −2.6 
               
               
                   
                 Serinc3 
                 0.04 
                 1.11 
                 0.47 
                 −1.17 
               
               
                   
                 Serpine1 
                 2.76 
                 1.83 
                 0 
                 0.99 
               
               
                   
                 Serping1 
                 −1.65 
                 −1.89 
                 −1.86 
                 −1.17 
               
               
                   
                 Serpinh1 
                 −1.94 
                 −0.75 
                 −1.9 
                 −0.58 
               
               
                   
                 Sertad1 
                 0.53 
                 0.65 
                 0.64 
                 1.12 
               
               
                   
                 Sesn1 
                 −0.44 
                 −0.37 
                 −1.08 
                 −0.97 
               
               
                   
                 Setd5 
                 0.51 
                 0 
                 −0.02 
                 −2.47 
               
               
                   
                 Sf1 
                 0.31 
                 0.11 
                 0.74 
                 1.08 
               
               
                   
                 Sf3a3 
                 0.59 
                 0.85 
                 0.89 
                 1.03 
               
               
                   
                 Sf3a3 /// 
                 0.91 
                 1.1 
                 0.85 
                 −0.07 
               
               
                   
                 LOC626830 
               
               
                   
                 Sf3b3 
                 0.6 
                 −0.03 
                 −0.01 
                 −1.5 
               
               
                   
                 Sfi1 /// 
                 −0.88 
                 −0.33 
                 −0.61 
                 −1.43 
               
               
                   
                 LOC673404 /// 
               
               
                   
                 LOC673420 /// 
               
               
                   
                 LOC673566 
               
               
                   
                 Sfpq 
                 −0.32 
                 −1.2 
                 −0.18 
                 −1.56 
               
               
                   
                 Sfrs1 
                 0.96 
                 1.56 
                 0.26 
                 −1.38 
               
               
                   
                 Sfrs2 
                 1.03 
                 1.26 
                 0.44 
                 −0.08 
               
               
                   
                 Sfrs2ip 
                 −0.09 
                 −0.29 
                 0.37 
                 1.28 
               
               
                   
                 Sfrs3 
                 0.88 
                 1.15 
                 0.37 
                 0.17 
               
               
                   
                 Sfrs3 /// 
                 0.18 
                 1.4 
                 0.57 
                 0.73 
               
               
                   
                 LOC632248 
               
               
                   
                 Sfrs4 
                 0.53 
                 0.61 
                 0.71 
                 1.13 
               
               
                   
                 Sfrs7 
                 0.86 
                 0.4 
                 0.22 
                 −1.75 
               
               
                   
                 Sft2d2 
                 1.3 
                 1.62 
                 1.01 
                 2.07 
               
               
                   
                 Sgce 
                 0.6 
                 1.22 
                 0.45 
                 0.47 
               
               
                   
                 Sgk2 
                 2.09 
                 0.94 
                 0.88 
                 1.18 
               
               
                   
                 Sgol1 
                 1.62 
                 1.58 
                 2.97 
                 1.97 
               
               
                   
                 Sgol2 
                 2.91 
                 1.8 
                 2.34 
                 1.89 
               
               
                   
                 Sgpl1 
                 0.04 
                 0.43 
                 −0.67 
                 −2.84 
               
               
                   
                 Sgpp1 
                 1.2 
                 1.13 
                 0 
                 −1.1 
               
               
                   
                 Sh2bp1 
                 −0.09 
                 0.1 
                 −0.64 
                 −1.8 
               
               
                   
                 Sh3bgrl 
                 0.32 
                 0.55 
                 −0.2 
                 −1.33 
               
               
                   
                 Sh3gl2 
                 −0.57 
                 −0.06 
                 −1.18 
                 −2.92 
               
               
                   
                 Sh3gl3 
                 −2.14 
                 −3.68 
                 −2.17 
                 −4.09 
               
               
                   
                 Sh3kbp1 
                 −0.13 
                 0.12 
                 −0.24 
                 −1.45 
               
               
                   
                 Sh3tc2 
                 −0.41 
                 −1.05 
                 −0.63 
                 −0.69 
               
               
                   
                 Shcbp1 
                 5.46 
                 2.8 
                 4.29 
                 2.89 
               
               
                   
                 Shfm1 
                 0.25 
                 0.01 
                 0.19 
                 1.03 
               
               
                   
                 Shh 
                 −0.06 
                 0.11 
                 −0.99 
                 −1.86 
               
               
                   
                 Shmt1 
                 0.79 
                 3.25 
                 0.07 
                 −1.51 
               
               
                   
                 Shoc2 
                 0.65 
                 1.13 
                 0.13 
                 −0.87 
               
               
                   
                 Shrm 
                 −0.15 
                 −0.13 
                 0.36 
                 1.24 
               
               
                   
                 Siah1a 
                 0.35 
                 0.1 
                 0.69 
                 1.47 
               
               
                   
                 Sidt1 
                 −0.67 
                 −0.37 
                 −0.63 
                 −1.44 
               
               
                   
                 Sip1 
                 0.64 
                 0.48 
                 0.99 
                 1.11 
               
               
                   
                 Siva 
                 0.47 
                 0.12 
                 0.55 
                 1.3 
               
               
                   
                 Six4 
                 −0.36 
                 −0.45 
                 −1.16 
                 −1.53 
               
               
                   
                 Ski 
                 −0.04 
                 −0.89 
                 0.13 
                 −1.67 
               
               
                   
                 Skp2 
                 1.23 
                 1.08 
                 1.69 
                 2.45 
               
               
                   
                 Slbp 
                 1.51 
                 1.68 
                 1.65 
                 1.78 
               
               
                   
                 Slc12a2 
                 −0.04 
                 0.44 
                 1.04 
                 1.47 
               
               
                   
                 Slc12a6 
                 −1.36 
                 0 
                 −0.88 
                 −3.79 
               
               
                   
                 Slc12a7 
                 −1.04 
                 −0.28 
                 −1.04 
                 −2.07 
               
               
                   
                 Slc16a1 
                 0.39 
                 0.3 
                 −1.15 
                 −0.43 
               
               
                   
                 Slc16a12 
                 −1.88 
                 −1.72 
                 −1.29 
                 −1.97 
               
               
                   
                 Slc16a3 
                 2.61 
                 1.59 
                 0 
                 1.85 
               
               
                   
                 Slc16a7 
                 −0.25 
                 −0.49 
                 −0.38 
                 −1.23 
               
               
                   
                 Slc16a9 
                 −1.38 
                 −1.79 
                 −1.33 
                 −1.02 
               
               
                   
                 Slc1a5 
                 −0.7 
                 −0.76 
                 −0.81 
                 −1.04 
               
               
                   
                 Slc22a17 
                 −0.93 
                 −1.13 
                 −0.95 
                 −1.65 
               
               
                   
                 Slc22a18 
                 −0.67 
                 −0.77 
                 −1.87 
                 −2.57 
               
               
                   
                 Slc23a1 
                 −0.77 
                 −0.85 
                 −1.07 
                 −1.19 
               
               
                   
                 Slc23a2 
                 −0.63 
                 −0.22 
                 −0.62 
                 −1.2 
               
               
                   
                 Slc24a6 
                 −1.01 
                 −0.16 
                 −0.42 
                 −0.22 
               
               
                   
                 Slc25a12 
                 0.9 
                 1.14 
                 0.41 
                 0.85 
               
               
                   
                 Slc25a24 
                 0.81 
                 1.18 
                 0.09 
                 −1.24 
               
               
                   
                 Slc25a35 
                 −1.07 
                 −0.92 
                 −0.92 
                 −1.43 
               
               
                   
                 Slc26a2 
                 −0.44 
                 −0.61 
                 −0.56 
                 −1.19 
               
               
                   
                 Slc29a1 
                 −0.78 
                 −0.7 
                 −0.34 
                 −1.1 
               
               
                   
                 Slc2a1 
                 1.81 
                 0.72 
                 0.36 
                 1.69 
               
               
                   
                 Slc30a1 
                 −1.17 
                 −1.21 
                 −0.13 
                 0.17 
               
               
                   
                 Slc35a3 
                 0.59 
                 1.24 
                 0.03 
                 −0.81 
               
               
                   
                 Slc35a5 
                 −0.52 
                 −0.68 
                 −0.75 
                 −1.1 
               
               
                   
                 Slc38a1 
                 −0.44 
                 −0.69 
                 2.3 
                 1.65 
               
               
                   
                 Slc39a10 
                 0.68 
                 0.8 
                 0.08 
                 −1.75 
               
               
                   
                 Slc40a1 
                 0.63 
                 1.06 
                 0.16 
                 −0.46 
               
               
                   
                 Slc44a2 
                 0.11 
                 0.62 
                 −0.38 
                 −1.33 
               
               
                   
                 Slc44a4 
                 −1.18 
                 −0.2 
                 0.08 
                 0.14 
               
               
                   
                 Slc4a4 
                 −0.72 
                 −1.3 
                 −0.28 
                 0.27 
               
               
                   
                 Slc4a7 
                 0.96 
                 0 
                 0 
                 −1.5 
               
               
                   
                 Slc5a1 
                 −2.81 
                 −2.45 
                 −2.07 
                 −1.78 
               
               
                   
                 Slc6a6 
                 −0.47 
                 −1.07 
                 −0.67 
                 −3.15 
               
               
                   
                 Slc9a2 
                 −1.02 
                 −1.07 
                 −0.36 
                 −0.34 
               
               
                   
                 Slc9a3r2 
                 −1.26 
                 0.1 
                 0.48 
                 0.46 
               
               
                   
                 Slco2a1 
                 −2.12 
                 −1.54 
                 −1.2 
                 −1.35 
               
               
                   
                 Slco3a1 
                 −2.66 
                 −2.1 
                 −1.54 
                 −4.55 
               
               
                   
                 Slfn2 
                 −0.44 
                 0.98 
                 0.15 
                 1.12 
               
               
                   
                 Slfn9 
                 1.95 
                 1.83 
                 1.86 
                 1.29 
               
               
                   
                 Smarca2 
                 −1.25 
                 −1.47 
                 −1.16 
                 −1.84 
               
               
                   
                 Smarca4 
                 −0.59 
                 −1.11 
                 −0.33 
                 −0.67 
               
               
                   
                 Smarcd3 
                 0.79 
                 3.13 
                 1.36 
                 1.6 
               
               
                   
                 Smc2l1 
                 1.85 
                 1.87 
                 3.02 
                 2.57 
               
               
                   
                 Smc4l1 
                 1.74 
                 0.8 
                 2.43 
                 0 
               
               
                   
                 Smc6l1 
                 0.96 
                 0.68 
                 1.07 
                 1.91 
               
               
                   
                 Smoc1 
                 −1.1 
                 −1.27 
                 −1.28 
                 −1.15 
               
               
                   
                 Smpdl3b 
                 1.87 
                 1.46 
                 2.29 
                 2.3 
               
               
                   
                 Snai2 
                 −1.13 
                 −0.87 
                 −0.86 
                 −0.89 
               
               
                   
                 Snap23 
                 0.17 
                 0.83 
                 −0.47 
                 −1.35 
               
               
                   
                 Snapc3 
                 −0.57 
                 0 
                 −0.62 
                 −3.79 
               
               
                   
                 Snf1lk2 
                 0.42 
                 0 
                 0.24 
                 −1.89 
               
               
                   
                 Snord22 
                 0.95 
                 1.35 
                 0.58 
                 0.3 
               
               
                   
                 Snrp1c 
                 0.53 
                 0.83 
                 0.83 
                 1.04 
               
               
                   
                 Snrpa1 
                 0.78 
                 0.97 
                 0.81 
                 1.24 
               
               
                   
                 Snrpd1 
                 0.83 
                 0.62 
                 0.59 
                 1.02 
               
               
                   
                 Snrpn 
                 −0.8 
                 −1.03 
                 −1.56 
                 −2.14 
               
               
                   
                 Snrpn /// Snurf 
                 −1.09 
                 −1.34 
                 −2.71 
                 −3.59 
               
               
                   
                 Snx25 
                 0.58 
                 0.61 
                 0.35 
                 1.03 
               
               
                   
                 Snx6 
                 0.84 
                 0.39 
                 0.85 
                 1.09 
               
               
                   
                 Soat1 
                 −3.57 
                 −3.14 
                 −1.84 
                 −0.03 
               
               
                   
                 Socs3 
                 0 
                 0 
                 0 
                 1.35 
               
               
                   
                 Sod1 
                 −0.66 
                 −0.92 
                 −1.09 
                 −1.74 
               
               
                   
                 Sod3 
                 −4.45 
                 −2.67 
                 −3.09 
                 −2.51 
               
               
                   
                 Solt 
                 2.99 
                 3.14 
                 2.92 
                 2.68 
               
               
                   
                 Son 
                 0.47 
                 0.91 
                 0.31 
                 −1.69 
               
               
                   
                 Sorcs2 
                 −1.06 
                 −1.05 
                 −0.73 
                 −1.3 
               
               
                   
                 Sorl1 
                 −0.5 
                 0.06 
                 −1.03 
                 −1.34 
               
               
                   
                 Sort1 
                 −1.07 
                 −1.01 
                 −1.01 
                 −1.05 
               
               
                   
                 Sox15 
                 −0.87 
                 −0.9 
                 −1.04 
                 −1.35 
               
               
                   
                 Sox4 /// 
                 0.24 
                 0.48 
                 −0.69 
                 −4.36 
               
               
                   
                 LOC672274 
               
               
                   
                 Spag5 
                 2.54 
                 2.64 
                 3.03 
                 2.16 
               
               
                   
                 Sparc 
                 −1.45 
                 −0.78 
                 −1.33 
                 1.49 
               
               
                   
                 Sparcl1 
                 −1.33 
                 −0.39 
                 −0.78 
                 1.9 
               
               
                   
                 Spata6 
                 −3.02 
                 −1.19 
                 −1.05 
                 −0.72 
               
               
                   
                 Spbc24 
                 4.32 
                 4.5 
                 1.93 
                 2.23 
               
               
                   
                 Spbc25 
                 2.53 
                 2.32 
                 2.56 
                 2.64 
               
               
                   
                 Sphk1 
                 −1.72 
                 −1.44 
                 −1.3 
                 −0.64 
               
               
                   
                 Spin 
                 0.43 
                 1.08 
                 0.13 
                 0.2 
               
               
                   
                 Spire2 
                 0.02 
                 0.35 
                 0.52 
                 1.04 
               
               
                   
                 Spnb2 
                 −0.34 
                 −1.05 
                 −0.34 
                 0.54 
               
               
                   
                 Spon1 
                 −2.09 
                 −2.52 
                 −1 
                 −1.86 
               
               
                   
                 Spop 
                 0.02 
                 0.35 
                 −0.73 
                 −1.5 
               
               
                   
                 Spp1 
                 0 
                 0 
                 0 
                 3.15 
               
               
                   
                 Sprr2f 
                 3.67 
                 3.83 
                 3.3 
                 3.88 
               
               
                   
                 Sprr2h 
                 0 
                 0 
                 0 
                 3.28 
               
               
                   
                 Spry2 
                 −0.48 
                 −0.84 
                 −1.09 
                 −0.98 
               
               
                   
                 Sptlc1 
                 −0.12 
                 0.95 
                 −1.34 
                 −0.66 
               
               
                   
                 Srd5a1 
                 −0.54 
                 −0.42 
                 −1.3 
                 −1.73 
               
               
                   
                 Sri 
                 −0.14 
                 −0.09 
                 −0.18 
                 −1.1 
               
               
                   
                 Srprb 
                 0.66 
                 1.19 
                 0.35 
                 −0.97 
               
               
                   
                 Srpx2 
                 −0.62 
                 −0.56 
                 −1.27 
                 −1.65 
               
               
                   
                 Srrm2 
                 −0.39 
                 −0.7 
                 −0.36 
                 −1.99 
               
               
                   
                 Ssh1 
                 −1.15 
                 −0.58 
                 −0.23 
                 0.44 
               
               
                   
                 Ssrp1 
                 0.74 
                 0.55 
                 0.77 
                 1.04 
               
               
                   
                 St14 
                 0.09 
                 0.15 
                 0.51 
                 1.09 
               
               
                   
                 Stag1 
                 0.94 
                 1.15 
                 1.09 
                 −0.52 
               
               
                   
                 Stag2 
                 0.86 
                 1.11 
                 −0.01 
                 −0.46 
               
               
                   
                 Stam2 
                 0.52 
                 1.34 
                 −0.03 
                 −0.4 
               
               
                   
                 Stambp 
                 0.07 
                 0.5 
                 −0.46 
                 −1.39 
               
               
                   
                 Stard13 
                 −0.48 
                 −0.76 
                 −0.72 
                 −1.09 
               
               
                   
                 Stch 
                 1.08 
                 0.64 
                 −0.04 
                 −1.05 
               
               
                   
                 Stfa3 
                 1.08 
                 0 
                 2.09 
                 3.42 
               
               
                   
                 Stmn1 /// 
                 0.86 
                 1.21 
                 1.57 
                 1.27 
               
               
                   
                 LOC639458 
               
               
                   
                 Stoml1 
                 −0.62 
                 −0.97 
                 −1.15 
                 −1.32 
               
               
                   
                 Stox2 
                 −0.59 
                 −0.6 
                 −1.74 
                 −0.87 
               
               
                   
                 Sub1 
                 −0.61 
                 −0.37 
                 −1.27 
                 −1.22 
               
               
                   
                 Sulf1 
                 −1.2 
                 −1.81 
                 −1.39 
                 −2.57 
               
               
                   
                 Suox 
                 −1.34 
                 −1.04 
                 −1.05 
                 −1.17 
               
               
                   
                 Supt16h 
                 1.15 
                 1.74 
                 0.39 
                 −1 
               
               
                   
                 Susd4 
                 −0.93 
                 −1.18 
                 −0.34 
                 0.05 
               
               
                   
                 Suv39h1 
                 1.33 
                 1.59 
                 1.67 
                 1.47 
               
               
                   
                 Syce2 
                 3.1 
                 2.84 
                 2.29 
                 2.82 
               
               
                   
                 Synj2bp 
                 −1.29 
                 0 
                 0 
                 −3.41 
               
               
                   
                 Sypl 
                 0.26 
                 0.61 
                 −0.06 
                 −1.44 
               
               
                   
                 Sytl2 
                 −0.68 
                 −0.65 
                 −0.76 
                 −1.34 
               
               
                   
                 Sytl3 
                 −1.07 
                 −0.03 
                 −0.97 
                 −1.03 
               
               
                   
                 Tacc3 
                 2.94 
                 2.08 
                 2.92 
                 2.32 
               
               
                   
                 Taf15 
                 0.38 
                 0 
                 0.21 
                 −1.8 
               
               
                   
                 Tagln 
                 −2.73 
                 −1.55 
                 −1.89 
                 0 
               
               
                   
                 Tagln2 
                 1.23 
                 1 
                 0.99 
                 1.04 
               
               
                   
                 Tagln2 /// 
                 1.71 
                 1.17 
                 1.57 
                 1.9 
               
               
                   
                 LOC672466 
               
               
                   
                 Tanc2 
                 −0.6 
                 −1.04 
                 −0.66 
                 0.27 
               
               
                   
                 Tardbp 
                 0.73 
                 1.12 
                 0.33 
                 −0.43 
               
               
                   
                 Tbc1d10b 
                 0.17 
                 0.26 
                 0.47 
                 1.27 
               
               
                   
                 Tbc1d8 
                 −0.21 
                 0.18 
                 −0.38 
                 −1.62 
               
               
                   
                 Tbc1d9 
                 −1.18 
                 −1.63 
                 −1.23 
                 −1.95 
               
               
                   
                 Tbx1 
                 −1.64 
                 −1.45 
                 0.13 
                 −0.43 
               
               
                   
                 Tbx3 
                 −0.9 
                 −0.95 
                 −0.82 
                 −1.42 
               
               
                   
                 Tcea1 
                 0.77 
                 1.17 
                 0.45 
                 −0.33 
               
               
                   
                 Tceal8 
                 0.05 
                 −0.11 
                 −0.6 
                 −1.14 
               
               
                   
                 Tcf12 
                 0.34 
                 0 
                 0.03 
                 −3.46 
               
               
                   
                 Tcf19 
                 2.84 
                 2.81 
                 2.78 
                 2.56 
               
               
                   
                 Tcf21 
                 −2.27 
                 −1.59 
                 −1.26 
                 0 
               
               
                   
                 Tcf25 
                 −0.36 
                 −0.83 
                 −0.6 
                 −1.26 
               
               
                   
                 Tcf4 
                 −0.62 
                 −1.2 
                 −0.19 
                 −0.87 
               
               
                   
                 Tcfap2a 
                 0.93 
                 2.11 
                 1.34 
                 1.44 
               
               
                   
                 Tcfap2c 
                 0.21 
                 0.63 
                 0.67 
                 1.18 
               
               
                   
                 Tcfcp2l1 
                 −1.04 
                 −0.59 
                 −0.05 
                 0.39 
               
               
                   
                 Tcn2 
                 −0.84 
                 −0.64 
                 −1.15 
                 −1.59 
               
               
                   
                 Tcof1 
                 0.25 
                 −0.11 
                 0.75 
                 1.23 
               
               
                   
                 Tcp11l2 
                 −0.62 
                 −0.64 
                 −0.71 
                 −1 
               
               
                   
                 Tcta 
                 −0.93 
                 −1.17 
                 −1.04 
                 −1.48 
               
               
                   
                 Tdrkh 
                 0 
                 0.63 
                 1.11 
                 0.87 
               
               
                   
                 Tead2 
                 0.29 
                 0.44 
                 0.72 
                 1.08 
               
               
                   
                 Tec 
                 0 
                 0.12 
                 1.29 
                 1.25 
               
               
                   
                 Terf1 
                 1.06 
                 1.32 
                 1.14 
                 0.84 
               
               
                   
                 Tex19 
                 0 
                 0 
                 1.74 
                 2.15 
               
               
                   
                 Tff1 
                 0.81 
                 0.95 
                 1.13 
                 0.92 
               
               
                   
                 Tfrc 
                 1.72 
                 1.63 
                 0.76 
                 −0.23 
               
               
                   
                 Tgfbi 
                 −1.74 
                 −1.93 
                 −1.46 
                 −0.36 
               
               
                   
                 Tgm2 
                 −1.73 
                 −1.01 
                 −0.29 
                 0.49 
               
               
                   
                 Tgoln1 
                 −0.23 
                 0.18 
                 −0.41 
                 −2.14 
               
               
                   
                 Th1l 
                 0.63 
                 0.35 
                 0.47 
                 1.03 
               
               
                   
                 Thbs1 /// 
                 0.03 
                 0.07 
                 −0.25 
                 −1.37 
               
               
                   
                 LOC640441 
               
               
                   
                 Thbs2 
                 −4.12 
                 −2.01 
                 0 
                 0 
               
               
                   
                 Thex1 
                 1.17 
                 0.85 
                 0.85 
                 1.02 
               
               
                   
                 Thoc4 
                 1.1 
                 1 
                 0.8 
                 1.24 
               
               
                   
                 Thoc4 /// 
                 0.94 
                 1.16 
                 0.86 
                 1.31 
               
               
                   
                 Refbp2 
               
               
                   
                 Thrap3 
                 0.21 
                 0.91 
                 0.01 
                 −1.04 
               
               
                   
                 Timeless 
                 2.85 
                 3.01 
                 2.15 
                 2.28 
               
               
                   
                 Timm50 
                 1.19 
                 0.69 
                 0.81 
                 0.91 
               
               
                   
                 Timm8a1 
                 1.2 
                 0.92 
                 0.57 
                 0.58 
               
               
                   
                 Timp2 
                 −1.69 
                 −1.2 
                 −1.25 
                 0 
               
               
                   
                 Tinagl 
                 0.97 
                 0.69 
                 1.21 
                 1.56 
               
               
                   
                 Tinf2 
                 0.85 
                 0.74 
                 1.78 
                 0.85 
               
               
                   
                 Tiparp 
                 −0.94 
                 −1.15 
                 −0.57 
                 0.4 
               
               
                   
                 Tipin 
                 1.84 
                 2.08 
                 1.84 
                 1.85 
               
               
                   
                 Tk1 
                 2.55 
                 2.56 
                 2.73 
                 1.48 
               
               
                   
                 Tk2 
                 −1.05 
                 −1.54 
                 −1.38 
                 −1.41 
               
               
                   
                 Tlr2 
                 −0.17 
                 0.37 
                 1.03 
                 1.33 
               
               
                   
                 Tm7sf2 
                 −0.8 
                 −0.89 
                 −1.51 
                 −1 
               
               
                   
                 Tmcc3 
                 0.11 
                 0.11 
                 −0.27 
                 −1.38 
               
               
                   
                 Tmed2 
                 0.85 
                 1.43 
                 −0.11 
                 −1.61 
               
               
                   
                 Tmem134 
                 0.13 
                 0.25 
                 −0.39 
                 −1.51 
               
               
                   
                 Tmem141 
                 −0.72 
                 −0.62 
                 −0.41 
                 −1.11 
               
               
                   
                 Tmem146 
                 −1.05 
                 −0.73 
                 −0.99 
                 −1.1 
               
               
                   
                 Tmem14a 
                 −0.67 
                 −1.24 
                 −0.77 
                 −0.86 
               
               
                   
                 Tmem16a 
                 −0.22 
                 −0.83 
                 −1.17 
                 −1.84 
               
               
                   
                 Tmem32 
                 0.6 
                 1.35 
                 0.2 
                 −0.81 
               
               
                   
                 Tmem33 
                 −0.01 
                 0.12 
                 −0.51 
                 −1.46 
               
               
                   
                 Tmem34 
                 −0.71 
                 −0.86 
                 −0.76 
                 −1.48 
               
               
                   
                 Tmem45a 
                 0 
                 0 
                 2.36 
                 4.83 
               
               
                   
                 Tmem48 
                 1.88 
                 1.93 
                 2.27 
                 1.15 
               
               
                   
                 Tmem49 
                 0.7 
                 0.67 
                 −0.07 
                 −1.07 
               
               
                   
                 Tmem57 
                 −0.54 
                 −1.1 
                 −0.61 
                 −2.26 
               
               
                   
                 Tmem58 
                 −1.42 
                 −1.81 
                 −1.44 
                 −0.45 
               
               
                   
                 Tmem64 
                 −1.05 
                 −0.82 
                 −0.77 
                 −1.31 
               
               
                   
                 Tmem71 
                 1.37 
                 0.8 
                 1.14 
                 0.97 
               
               
                   
                 Tmem8 
                 −1.73 
                 −2.13 
                 −0.94 
                 −1.37 
               
               
                   
                 Tmepai 
                 −1.12 
                 −1.21 
                 −0.63 
                 −0.79 
               
               
                   
                 Tmie 
                 0 
                 0.43 
                 2.74 
                 1.4 
               
               
                   
                 Tmpo 
                 1.21 
                 1.63 
                 1.38 
                 0.49 
               
               
                   
                 Tmprss11a 
                 −0.58 
                 0.04 
                 −0.98 
                 −1.72 
               
               
                   
                 Tmprss2 
                 −0.22 
                 −0.06 
                 −0.66 
                 −1.42 
               
               
                   
                 Tnc 
                 −2.9 
                 −2.62 
                 −0.74 
                 0 
               
               
                   
                 Tnfaip8l1 
                 0.75 
                 1.11 
                 1.8 
                 1.61 
               
               
                   
                 Tnfrsf12a 
                 2.8 
                 1.85 
                 1.84 
                 2.64 
               
               
                   
                 Tnfsf5ip1 
                 0.79 
                 1.15 
                 0.44 
                 0.2 
               
               
                   
                 Tnfsf9 
                 2.15 
                 1.64 
                 2.63 
                 3.8 
               
               
                   
                 Tnks1bp1 
                 0.01 
                 −0.12 
                 0.17 
                 1.01 
               
               
                   
                 Tnni2 
                 0.82 
                 1.03 
                 0.52 
                 0.89 
               
               
                   
                 Tnpo1 
                 −0.03 
                 0 
                 −0.41 
                 −1.44 
               
               
                   
                 Tnpo2 
                 0.54 
                 1.02 
                 0.36 
                 −0.66 
               
               
                   
                 Tnrc9 
                 −2.16 
                 −1.61 
                 −0.44 
                 −2.6 
               
               
                   
                 Tns1 
                 −1.18 
                 −1.44 
                 −1.12 
                 −0.03 
               
               
                   
                 Tns4 
                 −0.19 
                 −0.57 
                 −0.72 
                 −1.33 
               
               
                   
                 Tob2 
                 0.41 
                 0.38 
                 1.41 
                 1.97 
               
               
                   
                 Toe1 
                 0.74 
                 1.81 
                 0.76 
                 −0.33 
               
               
                   
                 Tomm20 
                 −0.81 
                 −0.81 
                 −0.82 
                 −1.03 
               
               
                   
                 Top2a 
                 3.8 
                 3.4 
                 4.27 
                 2.57 
               
               
                   
                 Top2b 
                 0.52 
                 0.64 
                 0.3 
                 −1.09 
               
               
                   
                 Topbp1 
                 1.65 
                 1.56 
                 1.55 
                 1.38 
               
               
                   
                 Topors 
                 0.11 
                 0.44 
                 1.01 
                 1.2 
               
               
                   
                 Tpi1 
                 0.85 
                 0.76 
                 0.53 
                 1.26 
               
               
                   
                 Tpm2 
                 −1.03 
                 −0.52 
                 −1.19 
                 1.36 
               
               
                   
                 Tpmt 
                 −0.02 
                 −0.19 
                 −0.7 
                 −1.2 
               
               
                   
                 Tpp1 
                 −0.62 
                 −1.06 
                 −0.88 
                 −1.12 
               
               
                   
                 Tpx2 
                 2.28 
                 2.08 
                 2.24 
                 2.41 
               
               
                   
                 Traip 
                 2.07 
                 2.32 
                 3.1 
                 1.67 
               
               
                   
                 Trak1 
                 −0.54 
                 −0.54 
                 0.64 
                 1.24 
               
               
                   
                 Trf 
                 −0.45 
                 −0.62 
                 −1.42 
                 −2.81 
               
               
                   
                 Trim11 
                 −0.46 
                 −0.25 
                 −0.53 
                 −1.02 
               
               
                   
                 Trim2 
                 1.26 
                 1.23 
                 3.5 
                 1.18 
               
               
                   
                 Trim25 
                 1.24 
                 1.2 
                 0.26 
                 0.96 
               
               
                   
                 Trim27 
                 1.4 
                 0.34 
                 0.12 
                 0.56 
               
               
                   
                 Trim37 
                 0.56 
                 0.54 
                 0.76 
                 1.44 
               
               
                   
                 Trim59 /// 
                 2.5 
                 5.12 
                 2.6 
                 0 
               
               
                   
                 LOC630539 
               
               
                   
                 Trim68 
                 −0.59 
                 −0.73 
                 −0.63 
                 −1.03 
               
               
                   
                 Trio 
                 −0.52 
                 0 
                 −0.51 
                 −1.27 
               
               
                   
                 Trip13 
                 2.13 
                 1.32 
                 1.91 
                 2.1 
               
               
                   
                 Trp53 
                 0.75 
                 1.32 
                 0.2 
                 0 
               
               
                   
                 Trp53i11 
                 −0.56 
                 −1.26 
                 −1.1 
                 −1.42 
               
               
                   
                 Trp53i5 
                 1.13 
                 1.32 
                 1.37 
                 1.39 
               
               
                   
                 Trp53inp2 
                 −1.27 
                 −0.99 
                 −0.43 
                 −0.44 
               
               
                   
                 Trp63 
                 −0.12 
                 −1.56 
                 −1.37 
                 −5.32 
               
               
                   
                 Trpv4 
                 −0.64 
                 −0.84 
                 −0.73 
                 −1.29 
               
               
                   
                 Tsc22d3 
                 −1 
                 −0.22 
                 −0.67 
                 −1.13 
               
               
                   
                 Tspan1 
                 0 
                 0 
                 2.55 
                 5.16 
               
               
                   
                 Tspan17 
                 −1.13 
                 −1.26 
                 −1.06 
                 −1.1 
               
               
                   
                 Tspan33 
                 0.88 
                 1.61 
                 −0.05 
                 1.49 
               
               
                   
                 Tspan6 
                 −0.45 
                 −0.59 
                 −0.75 
                 −1.08 
               
               
                   
                 Tspan7 
                 0.6 
                 1.13 
                 −0.17 
                 −0.92 
               
               
                   
                 Tspan8 
                 0.32 
                 1.09 
                 1.13 
                 1.57 
               
               
                   
                 Tssc4 
                 0.92 
                 0.78 
                 0.98 
                 1.11 
               
               
                   
                 Ttc1 
                 0.33 
                 0.26 
                 −0.49 
                 −1.65 
               
               
                   
                 Ttc12 /// 
                 −0.74 
                 −1.24 
                 −1.13 
                 −1.32 
               
               
                   
                 LOC640389 
               
               
                   
                 Ttc14 
                 −0.46 
                 −0.47 
                 −0.43 
                 −1.25 
               
               
                   
                 Ttc9c 
                 0.94 
                 1.53 
                 0.06 
                 −0.29 
               
               
                   
                 Ttk 
                 3.57 
                 2.93 
                 3.21 
                 2.86 
               
               
                   
                 Ttr 
                 −2.84 
                 −3.74 
                 −4.18 
                 −3.86 
               
               
                   
                 Tuba1 
                 −0.29 
                 −0.13 
                 0.38 
                 1.07 
               
               
                   
                 Tuba3 /// Tuba7 
                 0.78 
                 3.85 
                 0.97 
                 0.49 
               
               
                   
                 /// LOC384954 
               
               
                   
                 Tubb5 
                 0.52 
                 −0.26 
                 0.88 
                 1.1 
               
               
                   
                 Tug1 
                 0.31 
                 1.15 
                 −0.72 
                 −2.54 
               
               
                   
                 Twsg1 
                 0.7 
                 1.02 
                 0.05 
                 −1.52 
               
               
                   
                 Txlna 
                 0.76 
                 0.91 
                 1.04 
                 0.21 
               
               
                   
                 Txndc13 
                 −1.17 
                 −0.86 
                 −0.8 
                 −0.3 
               
               
                   
                 Txnip 
                 0.01 
                 0.69 
                 −0.59 
                 −1.72 
               
               
                   
                 Tyms /// Tyms- 
                 1.54 
                 1.79 
                 1.67 
                 1.34 
               
               
                   
                 ps 
               
               
                   
                 Tyro3 
                 −0.53 
                 −0.41 
                 −0.72 
                 −1.51 
               
               
                   
                 U2af1-rs1 
                 −0.69 
                 −0.48 
                 −0.68 
                 −1.16 
               
               
                   
                 Ubap2l 
                 0.41 
                 0.47 
                 0.64 
                 1.09 
               
               
                   
                 Ube2b 
                 −0.3 
                 −1.02 
                 −0.6 
                 −1.62 
               
               
                   
                 Ube2c 
                 4.42 
                 4.34 
                 5.13 
                 2.96 
               
               
                   
                 Ube2g2 
                 0.34 
                 1.2 
                 −0.13 
                 −2.6 
               
               
                   
                 Ube2h 
                 −0.47 
                 −0.76 
                 −0.51 
                 −2.03 
               
               
                   
                 Ube2s 
                 1.05 
                 1.07 
                 0.83 
                 0.79 
               
               
                   
                 Ube2t 
                 2.11 
                 2.2 
                 2.18 
                 2.18 
               
               
                   
                 Ube4b 
                 0.17 
                 1.24 
                 0.15 
                 −0.16 
               
               
                   
                 Ubtf 
                 −1.09 
                 −0.79 
                 1.23 
                 2.24 
               
               
                   
                 Uchl1 
                 −1.86 
                 −2.01 
                 −2.49 
                 −1.78 
               
               
                   
                 Uchl3 
                 0.39 
                 0 
                 0.36 
                 −1.71 
               
               
                   
                 Ugcg 
                 0.9 
                 1.37 
                 0.6 
                 −0.14 
               
               
                   
                 Ugdh 
                 −0.65 
                 −0.99 
                 −1.22 
                 −2 
               
               
                   
                 Ugt1a2 /// 
                 −0.37 
                 −0.42 
                 −0.89 
                 −1.78 
               
               
                   
                 Ugt1a6a /// 
               
               
                   
                 Ugt1a10 /// 
               
               
                   
                 Ugt1a7c /// 
               
               
                   
                 Ugt1a5 /// 
               
               
                   
                 Ugt1a9 /// 
               
               
                   
                 Ugt1a6b /// 
               
               
                   
                 Ugt1a1 
               
               
                   
                 Ugt2b34 
                 −0.59 
                 −0.73 
                 −1.18 
                 −2.48 
               
               
                   
                 Uhrf1 
                 5.21 
                 3.05 
                 2.85 
                 1.7 
               
               
                   
                 Unc13b 
                 0 
                 0 
                 1.6 
                 1.67 
               
               
                   
                 Unc5a 
                 −0.68 
                 −1.11 
                 −0.79 
                 −1.86 
               
               
                   
                 Unc84a 
                 −0.05 
                 0.3 
                 −0.21 
                 −1.25 
               
               
                   
                 Unc93b1 
                 −1 
                 −0.61 
                 −0.68 
                 −0.64 
               
               
                   
                 Ung 
                 2.26 
                 2.15 
                 2.29 
                 3.43 
               
               
                   
                 Upk1b 
                 −0.55 
                 −0.78 
                 −0.86 
                 −1.46 
               
               
                   
                 Upk2 
                 −0.99 
                 −1.03 
                 −0.62 
                 −0.85 
               
               
                   
                 Usp1 
                 1.64 
                 2.37 
                 1.52 
                 0.26 
               
               
                   
                 Usp15 
                 0.46 
                 0.88 
                 0.05 
                 −1.11 
               
               
                   
                 Usp27x 
                 −0.92 
                 −0.77 
                 −1.18 
                 −1.19 
               
               
                   
                 Usp32 
                 0.11 
                 0 
                 −0.43 
                 −1.53 
               
               
                   
                 Usp37 
                 0.36 
                 0.76 
                 0.91 
                 1.52 
               
               
                   
                 Usp6nl 
                 0.22 
                 0.37 
                 0.71 
                 1.72 
               
               
                   
                 Utx 
                 0.58 
                 0 
                 −0.08 
                 −1.58 
               
               
                   
                 Vamp3 
                 1.17 
                 1.74 
                 0.75 
                 0.24 
               
               
                   
                 Vamp4 
                 −0.86 
                 −1.1 
                 −0.66 
                 −0.74 
               
               
                   
                 Vapb 
                 −0.9 
                 −0.75 
                 −0.78 
                 −1.03 
               
               
                   
                 Vasn 
                 −0.31 
                 0.38 
                 0.14 
                 1.28 
               
               
                   
                 Vav3 
                 1.33 
                 1.7 
                 0.55 
                 −0.74 
               
               
                   
                 Vegfa 
                 2.07 
                 1.32 
                 0 
                 0.36 
               
               
                   
                 Vgll1 
                 0 
                 1.9 
                 1.84 
                 0 
               
               
                   
                 Vil2 
                 0.14 
                 0.11 
                 0.41 
                 1.06 
               
               
                   
                 Vim 
                 −1.16 
                 −1.32 
                 −1.81 
                 0.6 
               
               
                   
                 Vldlr 
                 −1.03 
                 −2.18 
                 −1.25 
                 −1.36 
               
               
                   
                 Vnn1 
                 0.87 
                 1.36 
                 1.24 
                 0.69 
               
               
                   
                 Vps25 
                 0.3 
                 0.32 
                 −0.43 
                 −1.09 
               
               
                   
                 Vps26b 
                 0.41 
                 0.37 
                 −0.19 
                 −1.28 
               
               
                   
                 Vps35 
                 1.11 
                 1.78 
                 −0.3 
                 −1.62 
               
               
                   
                 Vps41 
                 0 
                 0.22 
                 −0.56 
                 −1.91 
               
               
                   
                 Vrk1 
                 1.55 
                 1.5 
                 1.66 
                 1.72 
               
               
                   
                 W91776 
                 0.62 
                 0 
                 0.35 
                 −1.23 
               
               
                   
                 Wac 
                 0.26 
                 −0.6 
                 0.02 
                 −1.89 
               
               
                   
                 Wbp5 
                 0.5 
                 0.51 
                 0.8 
                 1.32 
               
               
                   
                 Wbscr27 
                 −1.23 
                 −1.51 
                 −1.53 
                 −1.29 
               
               
                   
                 Wdfy3 
                 −0.65 
                 −1.05 
                 −0.49 
                 −0.51 
               
               
                   
                 Wdhd1 
                 1.95 
                 2.22 
                 1.9 
                 1.84 
               
               
                   
                 Wdr1 
                 0.59 
                 1.05 
                 −0.24 
                 −1.7 
               
               
                   
                 Wdr23 
                 −0.51 
                 −0.46 
                 −0.54 
                 −1.15 
               
               
                   
                 Wdr40b 
                 −1.23 
                 −1.52 
                 −0.94 
                 −0.88 
               
               
                   
                 Wdr5 
                 0.95 
                 1.09 
                 0.7 
                 0.66 
               
               
                   
                 Wdr57 
                 0.65 
                 0.39 
                 0.59 
                 1.66 
               
               
                   
                 Wdr76 
                 1.12 
                 1.1 
                 1.05 
                 1.27 
               
               
                   
                 Wdr77 
                 0.72 
                 1.01 
                 0.13 
                 −0.5 
               
               
                   
                 Wdr8 
                 0.21 
                 0.15 
                 1.04 
                 0.85 
               
               
                   
                 Wee1 
                 1.32 
                 1.81 
                 0.9 
                 −0.58 
               
               
                   
                 Wfdc15 
                 −1.78 
                 −1.74 
                 −2.24 
                 −2.79 
               
               
                   
                 Whsc1 
                 0.88 
                 1.52 
                 1.56 
                 2.13 
               
               
                   
                 Wig1 
                 −0.93 
                 −0.8 
                 −0.95 
                 −1.24 
               
               
                   
                 Wiz 
                 2.01 
                 1.59 
                 1.28 
                 0 
               
               
                   
                 Wnk1 
                 −0.54 
                 −1.07 
                 −0.09 
                 0.94 
               
               
                   
                 Wnt5a 
                 −1.27 
                 −1.16 
                 −1.69 
                 −2.05 
               
               
                   
                 Wwtr1 
                 0.39 
                 0.16 
                 0.6 
                 1.37 
               
               
                   
                 Xist 
                 1.27 
                 2.37 
                 0.11 
                 −4.66 
               
               
                   
                 Xlr3a /// Xlr3b 
                 −1.39 
                 −0.48 
                 −0.5 
                 0.67 
               
               
                   
                 /// MGC76689 
               
               
                   
                 Yif1a 
                 0.19 
                 −1.36 
                 −0.4 
                 0.03 
               
               
                   
                 Yipf2 
                 −1 
                 −1.13 
                 −0.74 
                 −0.28 
               
               
                   
                 Ykt6 
                 0.82 
                 1.05 
                 −0.18 
                 −0.8 
               
               
                   
                 Ypel2 
                 −0.68 
                 0 
                 −1.26 
                 −1.86 
               
               
                   
                 Ypel5 
                 −0.63 
                 −0.87 
                 −0.67 
                 −1.2 
               
               
                   
                 Ywhah 
                 0.71 
                 0.92 
                 0.86 
                 1.08 
               
               
                   
                 Za20d2 
                 0.74 
                 1.18 
                 0.13 
                 −0.08 
               
               
                   
                 Za20d3 
                 0.29 
                 0.64 
                 −0.09 
                 −1.26 
               
               
                   
                 Zadh1 
                 −0.13 
                 −0.03 
                 −0.53 
                 −1.25 
               
               
                   
                 Zbtb20 
                 −0.98 
                 −1.84 
                 −0.63 
                 −1.17 
               
               
                   
                 Zbtb4 
                 −1.34 
                 −1.59 
                 −1.55 
                 −0.94 
               
               
                   
                 Zcchc7 
                 −0.13 
                 0 
                 −0.43 
                 −2.59 
               
               
                   
                 Zdhhc14 
                 −0.19 
                 0.43 
                 −0.52 
                 −1.31 
               
               
                   
                 Zdhhc18 
                 0.04 
                 0.42 
                 0.88 
                 1.03 
               
               
                   
                 Zdhhc9 
                 −0.91 
                 −1.14 
                 −1.15 
                 −0.78 
               
               
                   
                 Zfand3 
                 −0.16 
                 −0.02 
                 0.46 
                 1.2 
               
               
                   
                 Zfml 
                 0.42 
                 0.79 
                 0.06 
                 −1.48 
               
               
                   
                 Zfp101 
                 1.14 
                 0.95 
                 0.96 
                 0.07 
               
               
                   
                 Zfp185 
                 1.73 
                 1.82 
                 1.77 
                 0.75 
               
               
                   
                 Zfp192 
                 −0.29 
                 −0.65 
                 −0.56 
                 −1.14 
               
               
                   
                 Zfp207 
                 −0.21 
                 0.32 
                 −0.67 
                 −2.8 
               
               
                   
                 Zfp260 /// 
                 0.43 
                 0.87 
                 −0.43 
                 −1.7 
               
               
                   
                 LOC635007 
               
               
                   
                 Zfp313 
                 0.22 
                 0.79 
                 −0.26 
                 −1.06 
               
               
                   
                 Zfp367 
                 1.1 
                 1.13 
                 1.22 
                 1.28 
               
               
                   
                 Zfp369 
                 −0.3 
                 −0.64 
                 −0.38 
                 −1.08 
               
               
                   
                 Zfp445 
                 0.37 
                 0.52 
                 −0.33 
                 −1.82 
               
               
                   
                 Zfp458 
                 −1.15 
                 −0.56 
                 0.18 
                 −0.6 
               
               
                   
                 Zfp462 
                 −3.32 
                 −4.55 
                 −2.46 
                 −2.95 
               
               
                   
                 Zfp467 
                 −0.93 
                 −1.19 
                 −0.92 
                 −0.94 
               
               
                   
                 Zfp608 
                 −0.12 
                 0 
                 −0.39 
                 −1.72 
               
               
                   
                 Zfp62 
                 0.23 
                 0.43 
                 −0.25 
                 −1.49 
               
               
                   
                 Zfp622 
                 −0.35 
                 −1.19 
                 −0.26 
                 0.34 
               
               
                   
                 Zfp655 
                 1.02 
                 1.06 
                 0.37 
                 −0.66 
               
               
                   
                 Zfp91 
                 0.4 
                 0.11 
                 0.67 
                 1.84 
               
               
                   
                 Zfpn1a2 
                 0.02 
                 −0.41 
                 0.02 
                 −2.02 
               
               
                   
                 Zfpn1a3 
                 −0.61 
                 −0.23 
                 −0.07 
                 −1.06 
               
               
                   
                 Zfyve27 
                 −0.84 
                 −1.16 
                 −0.42 
                 −0.84 
               
               
                   
                 Zmat5 
                 0 
                 −2.86 
                 −2.45 
                 −2.39 
               
               
                   
                 Zmym1 
                 0.77 
                 0.71 
                 1.15 
                 1.01 
               
               
                   
                 Zmym6 
                 −0.55 
                 −0.27 
                 −0.15 
                 −1.01 
               
               
                   
                 Zmynd19 
                 1.39 
                 1.19 
                 1.2 
                 1.49 
               
               
                   
                 Znhit3 
                 0.91 
                 1.48 
                 0.5 
                 0.21 
               
               
                   
                 Zranb3 
                 1.09 
                 1.11 
                 1.19 
                 1.29 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                   
                 TABLE 2 
               
             
             
               
                   
                   
               
               
                   
                 3 Wk 
                 6 Wk 
                 20 Wk 
                 30 Wk 
               
             
          
           
               
                 Top Functions 
                 Score 
                 Focus Mol 
                 Up/Down 
                 Score 
                 Focus Mol 
                 Up/Down 
                 Score 
                 Focus Mol 
                 Up/Down 
                 Score 
                 Focus Mol 
                 Up/Down 
               
               
                   
               
               
                 DRRR, CC, C 
                 43 
                 35/35 
                 32/3  
                 43 
                 35/35 
                 33/2  
                 43 
                 35/35 
                 32/3  
                 43 
                 35/35 
                 33/2  
               
               
                 CM, CAO, HSDF 
                 40 
                 34/35 
                 16/18 
                 40 
                 34/35 
                 14/19 
                 40 
                 34/35 
                 11/21 
                 40 
                 34/35 
                 10/22 
               
               
                 CC, CM, CAO 
                 40 
                 34/35 
                 24/10 
                 40 
                 34/35 
                 22/9  
                 40 
                 34/35 
                 24/10 
                 40 
                 34/35 
                 24/10 
               
               
                 C, GID, GD 
                 40 
                 34/35 
                 23/11 
                 40 
                 34/35 
                 25/9  
                 40 
                 34/35 
                 18/16 
                 40 
                 34/35 
                 13/20 
               
               
                 RPTM, CAO, CGP 
                 40 
                 34/35 
                 22/12 
                 40 
                 34/35 
                 22/10 
                 40 
                 34/35 
                 22/12 
                 40 
                 34/35 
                 17/16 
               
               
                 DRRR, GE, OD 
                 40 
                 34/35 
                 22/9  
                 40 
                 34/35 
                 29/5  
                 40 
                 34/35 
                 21/13 
                 40 
                 34/35 
                 20/14 
               
               
                 GE, DRRR, CAO 
                 38 
                 33/35 
                 25/8  
                 38 
                 34/35 
                 24/9  
                 38 
                 33/35 
                 24/9  
                 38 
                 33/35 
                 22/11 
               
               
                 RPTM, CAO, ESDF 
                 38 
                 33/35 
                 25/7  
                 38 
                 33/35 
                 24/5  
                 38 
                 33/35 
                 25/8  
                 38 
                 33/35 
                 15/18 
               
               
                 AAM, SMB, C 
                 35 
                 32/35 
                 24/8  
                 35 
                 32/35 
                 25/7  
                 35 
                 32/35 
                 19/13 
                 35 
                 32/35 
                 17/15 
               
               
                 DRRR, CC, CAO 
                 35 
                 32/35 
                 27/5  
                 35 
                 32/35 
                 26/5  
                 35 
                 32/35 
                 25/7  
                 35 
                 32/35 
                 21/9  
               
               
                 CMB, CD, CSDF 
                 35 
                 32/35 
                 23/8  
                 35 
                 32/35 
                 20/9  
                 35 
                 32/35 
                 19/13 
                 35 
                 32/35 
                 21/10 
               
               
                 CAO, CFM, SMSDF 
                 33 
                 31/35 
                 18/12 
                 33 
                 31/35 
                 19/10 
                 33 
                 31/35 
                 13/18 
                 33 
                 31/35 
                 8/23 
               
               
                 DRRR, C, RUD 
                 33 
                 31/35 
                 23/8  
                 33 
                 31/35 
                 23/7  
                 33 
                 31/35 
                 21/8  
                 33 
                 31/35 
                 22/8  
               
               
                 CC, C, CMP 
                 33 
                 31/35 
                 22/9  
                 33 
                 31/35 
                 22/9  
                 33 
                 31/35 
                 22/9  
                 33 
                 31/35 
                 20/8  
               
               
                 CMB, SMB, C 
                 33 
                 31/35 
                 19/12 
                 33 
                 31/35 
                 19/10 
                 33 
                 31/35 
                 15/15 
                 33 
                 31/35 
                 12/18 
               
               
                 CGP, CC, C 
                 33 
                 31/35 
                 19/12 
                 33 
                 31/35 
                 19/12 
                 33 
                 31/35 
                 17/14 
                 33 
                 31/35 
                 17/14 
               
               
                 C, GID, RSD 
                 31 
                 30/35 
                 10/19 
                 31 
                 30/35 
                 12/17 
                 31 
                 30/35 
                 7/22 
                 31 
                 30/35 
                  5/25 
               
               
                 CAO, DRRR, AAM 
                 31 
                 30/35 
                 22/8  
                 31 
                 30/35 
                 23/7  
                 31 
                 30/35 
                 20/9  
                 31 
                 30/35 
                 15/14 
               
               
                 GE, CAO, AAM 
                 29 
                 29/35 
                 14/14 
                 29 
                 29/35 
                 14/13 
                 29 
                 29/35 
                  9/19 
                 29 
                 29/35 
                  7/21 
               
               
                 DM, MT, SMB 
                 29 
                 29/35 
                 19/9  
                 29 
                 29/35 
                 20/8  
                 29 
                 29/35 
                 15/13 
                 29 
                 29/35 
                 14/13 
               
               
                 C, CTCSI, RSD 
                 27 
                 29/35 
                  7/22 
                 27 
                 29/35 
                  9/18 
                 27 
                 29/35 
                  6/22 
                 27 
                 29/35 
                  9/18 
               
               
                 CI, CVD, AAM 
                 26 
                 27/35 
                  9/17 
                 26 
                 27/35 
                 10/16 
                 26 
                 27/35 
                 10/17 
                 26 
                 27/35 
                 10/15 
               
               
                 CCP, PD, CSDF 
                 26 
                 27/35 
                 10/17 
                 26 
                 27/35 
                 10/15 
                 26 
                 27/35 
                  3/23 
                 26 
                 27/35 
                  2/24 
               
               
                 GE, CD, C 
                 26 
                 27/35 
                 21/6  
                 26 
                 27/35 
                 22/4  
                 26 
                 27/35 
                 21/6  
                 26 
                 27/35 
                 20/6  
               
               
                 C, CC, ESD 
                 26 
                 27/35 
                 20/7  
                 26 
                 27/35 
                 19/6  
                 26 
                 27/35 
                 20/6  
                 26 
                 27/35 
                 20/7  
               
               
                 CAO, ID, ND 
                 25 
                 28/35 
                  7/21 
                 25 
                 28/35 
                  9/16 
                 25 
                 28/35 
                  7/19 
                 25 
                 28/35 
                  6/19 
               
               
                 CS, CAO, CMP 
                 23 
                 25/35 
                  9/15 
                 23 
                 25/35 
                 12/12 
                 23 
                 25/35 
                  9/16 
                 23 
                 25/35 
                  8/15 
               
               
                 CTCSI, HSDF, ILSDF 
                 23 
                 25/35 
                 13/12 
                 23 
                 25/35 
                 14/10 
                 23 
                 25/35 
                 12/13 
                 23 
                 25/35 
                 11/13 
               
               
                 CD, CGP, IR 
                 23 
                 25/35 
                  2/21 
                 23 
                 25/35 
                  1/21 
                 23 
                 25/35 
                  4/19 
                 23 
                 25/35 
                  7/17 
               
               
                 LM, SMB, C 
                 21 
                 24/35 
                  9/13 
                 21 
                 24/35 
                  9/13 
                 21 
                 24/35 
                  9/15 
                 21 
                 24/35 
                 12/12 
               
               
                 GE, CC, C 
                 21 
                 24/35 
                 18/6  
                   
                   
                   
                 20 
                 23/35 
                 16/7  
               
               
                 CVD, HD, CAO 
                 20 
                 23/35 
                 10/12 
                 20 
                 23/35 
                 11/12 
                 20 
                 23/35 
                  8/14 
                 20 
                 23/35 
                  8/13 
               
               
                 LM, MD, NAM 
                 20 
                 23/35 
                  9/13 
                 20 
                 23/35 
                 12/11 
                 20 
                 23/35 
                 10/12 
                 20 
                 23/35 
                 10/13 
               
               
                 LM, SMB, C 
                 20 
                 23/35 
                 14/9  
                 20 
                 23/35 
                 12/11 
               
               
                 GE, CC, VF 
                   
                   
                   
                 20 
                 23/35 
                 16/6  
               
               
                 TM, CSDF, CDT 
                 18 
                 22/35 
                 11/10 
               
               
                 CFM, CGP, HSDF 
                 18 
                 22/35 
                 10/12 
                   
                   
                   
                   
                   
                   
                 17 
                 21/35 
                  1/20 
               
               
                 AAM, PTM, SMB 
                 18 
                 22/35 
                 13/9  
                 17 
                 21/35 
                 10/8  
                 17 
                 21/35 
                 13/8  
                 18 
                 22/35 
                  9/13 
               
               
                 AD, CVD, GD 
                 18 
                 22/35 
                  7/15 
                   
                   
                   
                 17 
                 21/35 
                  5/15 
                 18 
                 22/35 
                  5/17 
               
               
                 LM, SMB, MT 
                   
                   
                   
                   
                   
                   
                 18 
                 22/35 
                 10/12 
                 17 
                 21/35 
                  7/14 
               
               
                 CS, CMB, DM 
                   
                   
                   
                   
                   
                   
                 18 
                 22/35 
                 11/11 
               
               
                 C, CCP, RPD 
                   
                   
                   
                 15 
                 20/35 
                 11/9  
                 17 
                 21/35 
                 12/9  
                 18 
                 22/35 
                 14/6  
               
               
                 CVD, TM, CMP 
                 17 
                 21/35 
                 10/11 
                 18 
                 22/35 
                 11/11 
                 15 
                 20/35 
                 10/10 
               
               
                 CS, CD, CTDF 
                 17 
                 21/35 
                  9/11 
                 15 
                 20/35 
                 10/9  
               
               
                 GE, ESD, GD 
                 17 
                 16/19 
                  5/11 
                 17 
                 16/19 
                  5/11 
                 17 
                 16/19 
                  3/13 
                 17 
                 16/19 
                  3/13 
               
               
                 DRRR, NAM, SMB 
                   
                   
                   
                 17 
                 21/35 
                 10/7  
                 15 
                 20/35 
                  8/12 
                 17 
                 21/35 
                  7/13 
               
               
                 C, GID, NTD 
                   
                   
                   
                 17 
                 21/35 
                  5/15 
               
               
                 GD, SMD, CSDF 
                 16 
                 21/35 
                  8/12 
               
               
                 CC, C, GE 
                 16 
                 20/34 
                 12/7  
                   
                   
                   
                 16 
                 20/34 
                 11/9  
               
               
                 CD, LM, MT 
                 16 
                 15/18 
                 10/4  
                 16 
                 15/18 
                 10/5  
                 16 
                 15/18 
                 9/6 
                 16 
                 15/18 
                 7/8 
               
               
                 CC, CTDF, PTM 
                   
                   
                   
                 15 
                 20/35 
                 9/8 
                 16 
                 21/35 
                 11/10 
               
               
                 AAM, PTM, SMB 
                 15 
                 20/35 
                 12/8  
                 15 
                 20/35 
                 14/4  
                 15 
                 20/35 
                 10/9  
                 15 
                 20/35 
                 10/10 
               
               
                 LM, MT, SMB 
                   
                   
                   
                   
                   
                   
                 15 
                 20/35 
                 11/9  
               
               
                 CTCSI, CAO, CDT 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 15 
                 20/35 
                  9/11 
               
               
                 PTM, PF, RSDF 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 15 
                 20/35 
                  4/15 
               
               
                 CSDF, CD, CGP 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 15 
                 20/35 
                  9/11 
               
               
                   
               
               
                 Legend 
               
               
                 C Cancer 
               
               
                 CAO Cellular Assembly and Organization 
               
               
                 GE Gene Expression 
               
               
                 CC Cell Cycle 
               
               
                 DRRR DNA Replication, Recombination, and Repair 
               
               
                 AAM Amino Acid Metabolism 
               
               
                 CD Cellular Development 
               
               
                 LM Lipid Metabolism 
               
               
                 SMB Small Molecule Biochemistry 
               
               
                 CVD Cardiovascular Disease 
               
               
                 CGP Cellular Growth and Proliferation 
               
               
                 CM Cellular Movement 
               
               
                 TM Tissue Morphology 
               
               
                 CMB Carbohydrate Metabolism 
               
               
                 CS Cell Signaling 
               
               
                 GD Genetic Disorder 
               
               
                 RPTM RNA Post-Transcriptional Modification 
               
               
                 CFM Cellular Function and Maintenance 
               
               
                 CSDF Cardiovascular System Development and Function 
               
               
                 CTCSI Cell-To-Cell Signaling and Interaction 
               
               
                 CMP Cell Morphology 
               
               
                 GID Gastrointestinal Disease 
               
               
                 PTM Post-Translational Modification 
               
               
                 AD Auditory Disease 
               
               
                 CCP Cellular Compromise 
               
               
                 CI Cardiac Infarction 
               
               
                 DM Drug Metabolism 
               
               
                 ESD Endocrine System Disorders 
               
               
                 HSDF Hematological System Development and Function 
               
               
                 MT Molecular Transport 
               
               
                 HD Hematological Disease 
               
               
                 ID Inflammatory Disease 
               
               
                 MD Metabolic Disease 
               
               
                 PD Protein Degradation 
               
               
                 RSD Reproductive System Disease 
               
               
                 SMD Skeletal and Muscular Disorders 
               
               
                 CDT Cell Death 
               
               
                 CTDF Connective Tissue Development and Function 
               
               
                 ESDF Endocrine System Development and Function 
               
               
                 HSDF Hair and Skin Development and Function 
               
               
                 ILSDF Immune and Lymphatic System Development and Function 
               
               
                 IR Immune Response 
               
               
                 NAM Nucleic Acid Metabolism 
               
               
                 ND Neurological Disease 
               
               
                 OD Organ Development 
               
               
                 RUD Renal and Urological Disease 
               
               
                 SMSDF Skeletal and Muscular System Development and Function 
               
               
                 VF Viral Function 
               
               
                 NTD Nutritional Disease 
               
               
                 RPD Respiratory Disease 
               
               
                 PF Protein Folding 
               
               
                 RSDF Respiratory System Development and Function 
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
             
             
               
                 AASDHPPT 
                 GGA2 
                 POLA1 
               
               
                 AATF 
                 GINS4 
                 POLB 
               
               
                 ABCA1* 
                 GIPC2 
                 POLD1 
               
               
                 ABCA3* 
                 GJB6* 
                 POLD2 
               
               
                 ABCC3* 
                 GLDC 
                 POLG 
               
               
                 ABHD6 
                 GLRX 
                 PON3* 
               
               
                 ABHD8 
                 GLS 
                 POSTN* 
               
               
                 ABHD12 
                 GMCL1 
                 PPAP2B* 
               
               
                 ABHD14B 
                 GMFB 
                 PPARA 
               
               
                 ACAA2 
                 GMNN 
                 PPFIBP2 
               
               
                 ACER2 
                 GNE 
                 PPM1B 
               
               
                 ACLY 
                 GNG10* 
                 PPM1H 
               
               
                 ACOX1 
                 GNS 
                 PPP1R8 
               
               
                 ACTG2 (includes EG: 72) 
                 GOLIM4 
                 PPP1R12A 
               
               
                 ADAM10* 
                 GOLPH3 
                 PRDM4 
               
               
                 ADAM28* 
                 GOLPH3L 
                 PRDX4 
               
               
                 ADAMDEC1* 
                 GORASP2 
                 PRIM1 
               
               
                 ADH7 
                 GOT1 
                 PRIM2 
               
               
                 ADI1 
                 GOT2 
                 PRKAR2A 
               
               
                 ADK 
                 GPBP1 
                 PRKAR2B 
               
               
                 AEBP1 
                 GPC4* 
                 PRKCH 
               
               
                 AGPAT1 
                 GPLD1 
                 PRKCI 
               
               
                 AGPS 
                 GPM6A* 
                 PROCR* 
               
               
                 AHCYL1 
                 GPR137B* 
                 PRPF4B 
               
               
                 AHNAK 
                 GPSM2 
                 PRSS23* 
               
               
                 AHR 
                 GPX3* 
                 PSAP* 
               
               
                 AK3 
                 GRHL2 
                 PSCA* (includes EG: 8000) 
               
               
                 AKAP10 
                 GRINA 
                 PSEN1* 
               
               
                 AKAP12 
                 GSTA3 
                 PSME4 
               
               
                 ALDH2 
                 GSTM1 
                 PSMG2 
               
               
                 ALDH1L1 
                 GSTM2 
                 PSTPIP2 
               
               
                 ALDH3A1 
                 GSTM4 
                 PTBP2 
               
               
                 ALDOC 
                 GSTM5 
                 PTOV1 
               
               
                 AMN* 
                 GSTM3 (includes EG: 2947) 
                 PTP4A1 
               
               
                 AMOT* 
                 GTF2H4 
                 PTP4A2* 
               
               
                 ANK1* 
                 GTPBP2 
                 PTPLAD1 
               
               
                 ANKRD43 
                 H19 
                 PTPLB 
               
               
                 ANKRD46 
                 H1F0 
                 PTPRB* 
               
               
                 ANO1 
                 H2AFV (includes EG: 94239) 
                 PTPRE* 
               
               
                 ANP32B 
                 H2AFX 
                 PTPRR* 
               
               
                 ANP32E 
                 HADH 
                 PTPRU* 
               
               
                 ANTXR1* 
                 HAT1 
                 PTTG1 
               
               
                 ANUBL1 
                 HBP1 
                 PVRL2* 
               
               
                 ANXA3 
                 HBS1L 
                 PVRL3* 
               
               
                 ANXA6* 
                 HCK 
                 RAB10 
               
               
                 AOF1 
                 HDAC11 
                 RAB14 
               
               
                 AOX1 
                 HDGF* 
                 RAD21 
               
               
                 AP3B1 
                 HERPUD1 
                 RAI14 
               
               
                 APBB2 
                 HEXIM1 
                 RANGAP1 
               
               
                 APCDD1 
                 HIF1A 
                 RAP2C 
               
               
                 API5 
                 HINT3 
                 RARG 
               
               
                 APLP2* 
                 HIP1R 
                 RARRES2* 
               
               
                 APOC1* 
                 HIST1H1C 
                 RASA3* 
               
               
                 APP* 
                 HMG20A 
                 RASL11B 
               
               
                 AQP1* 
                 HMGCS2 
                 RASSF3 
               
               
                 AQP3* 
                 HMOX1 
                 RBL1 
               
               
                 ARAF 
                 HN1 
                 RBM5 
               
               
                 ARCN1 
                 HNRNPR 
                 RBM6 
               
               
                 ARF1 
                 HNRNPU 
                 RBM14 
               
               
                 ARF4 
                 HPGD 
                 RBM39 
               
               
                 ARFIP2 
                 HR 
                 RBMS1 
               
               
                 ARHGAP26 
                 HRSP12 
                 RBMS3 
               
               
                 ARL6 
                 HS3ST1 
                 RBMX 
               
               
                 ARL5B 
                 HSD17B2 
                 RBP1* 
               
               
                 ARMCX1 
                 HSD17B12 
                 RCAN1 
               
               
                 ARMCX3 
                 HSPA13 
                 RCBTB2 
               
               
                 ARRDC3 
                 HSPA14 
                 RDBP 
               
               
                 ARSA 
                 HTATIP2 
                 REEP5* 
               
               
                 ASB8 
                 HTR4* 
                 RFC4 
               
               
                 ASCC2 
                 HTRA1* 
                 RGS2 
               
               
                 ATAD2 
                 ICOSLG* 
                 RGS5* 
               
               
                 ATF4 
                 ID2 
                 RGS10 
               
               
                 ATL2 
                 ID4 
                 RHOC* 
               
               
                 ATP1B1* 
                 IDE* 
                 RHOQ* 
               
               
                 ATP2A2 
                 IDH1 
                 RHOU 
               
               
                 ATP6V0A1 
                 IDS 
                 RIPK3* 
               
               
                 ATRN* 
                 IER3 
                 RNASE4* 
               
               
                 ATRX 
                 IGF2* 
                 RNASEH2B 
               
               
                 BACE1 
                 IGF1R* 
                 RNF13 
               
               
                 BACE2 
                 IGFBP2* 
                 RNF14 
               
               
                 BAZ1A 
                 IGFBP4* 
                 RNF125 
               
               
                 BCAM* 
                 IGFBP5* 
                 RNF144B 
               
               
                 BCL10 
                 IGFBP6* 
                 RNF19A 
               
               
                 BCOR 
                 IL18* 
                 RNPS1 
               
               
                 BFAR 
                 IL17RE 
                 ROD1 
               
               
                 BGN* 
                 IL1RN* 
                 RPA1 
               
               
                 BHLHE40 
                 IL6ST* 
                 RPA3 
               
               
                 BLM 
                 IMPA2 
                 RPP30 
               
               
                 BMP2* 
                 IMPACT 
                 RSAD2 
               
               
                 BOK 
                 INMT 
                 RTN4* 
               
               
                 BPTF 
                 INTS6 
                 RUSC1 
               
               
                 BRAF 
                 IPP 
                 S100A1 
               
               
                 BRCA1 
                 IRF1 
                 S100A10 
               
               
                 BRCA2 
                 IRF2 
                 S100A14 
               
               
                 BRWD1 
                 IRF8 
                 SAPS3 
               
               
                 BST2* 
                 IRS1 
                 SATB1 
               
               
                 BXDC5 
                 ITPK1 
                 SBSN 
               
               
                 BZW1 
                 ITPR1 
                 SCAMP1 
               
               
                 C1GALT1* 
                 IVL 
                 SCO1 
               
               
                 CACNA1H* 
                 JMJD1C 
                 SCOC 
               
               
                 CALML3 
                 JUN 
                 SDC1* 
               
               
                 CAMK2B 
                 KAT2B 
                 SDC2* 
               
               
                 CAMK2D 
                 KCNE1* 
                 SDC4* 
               
               
                 CAMK2N1* 
                 KCNK6* 
                 SDPR* 
               
               
                 CAP1* 
                 KCTD3 
                 SEC63 
               
               
                 CAPN1 
                 KCTD15 
                 SEC61A1 
               
               
                 CAPN2 
                 KDELR3 
                 SEH1L 
               
               
                 CAPRIN1* 
                 KDM5D 
                 SELE* 
               
               
                 CARHSP1 
                 KDM6A 
                 SEMA4C* 
               
               
                 CASC4 
                 KHSRP 
                 SEMA4G* 
               
               
                 CASK* 
                 KLF4 
                 SENP8 
               
               
                 CASP2 
                 KLF5 
                 SERINC1* 
               
               
                 CASP3 
                 KLHL22 
                 SERPING1* 
               
               
                 CASP7 
                 KLHL24 
                 SERPINH1* 
               
               
                 CAT 
                 KLK6* 
                 SERTAD1 
               
               
                 CAV1* 
                 KPNA1 
                 SESN1 
               
               
                 CBX2 
                 KPNA3 
                 SETD5 
               
               
                 CBX5 
                 KPNB1 
                 SF1 
               
               
                 CCDC69 
                 LAPTM4A 
                 SFPQ 
               
               
                 CCDC80 
                 LASP1 
                 SFRS1 
               
               
                 CCDC99 
                 LBH 
                 SFRS2 
               
               
                 CCND1 
                 LBR 
                 SFRS3 
               
               
                 CCNG1 
                 LCN2* 
                 SFRS7 
               
               
                 CCNG2 
                 LDHA 
                 SFRS2IP 
               
               
                 CCNL2 
                 LDHB 
                 SGCE* 
               
               
                 CCPG1 
                 LGALS1* 
                 SGPL1 
               
               
                 CCRN4L 
                 LGALS3* 
                 SGPP1 
               
               
                 CD44* 
                 LIMA1 
                 SH3BGRL 
               
               
                 CD55* 
                 LIMD1 
                 SH3GL2* 
               
               
                 CD99L2* 
                 LIMK2 
                 SH3GL3 
               
               
                 CDC6 
                 LIMS1* 
                 SHFM1 
               
               
                 CDC73 
                 LIN9 
                 SHH* 
               
               
                 CDC37L1 
                 LIN7C 
                 SHISA4 
               
               
                 CDC42EP3 
                 LMAN2 
                 SHOC2 
               
               
                 CDC45L 
                 LMBR1* 
                 SIDT1 
               
               
                 CDCA4 
                 LMNB1 
                 SKI 
               
               
                 CDKN3 
                 LMO1 
                 SKP2 
               
               
                 CDKN1A 
                 LONRF3 
                 SLBP 
               
               
                 CDKN1C 
                 LPIN1 
                 SLC12A2* 
               
               
                 CDO1 
                 LPL 
                 SLC12A6* 
               
               
                 CELA1* 
                 LPP 
                 SLC12A7* 
               
               
                 CENPA 
                 LRP1* 
                 SLC16A9 
               
               
                 CENPE 
                 LRRC50 
                 SLC16A12 
               
               
                 CFD* 
                 LRRC8E 
                 SLC1A5* 
               
               
                 CHKA 
                 LSM3 
                 SLC22A17* 
               
               
                 CHUK 
                 LSM5 
                 SLC22A18* 
               
               
                 CIRBP 
                 LSM8 
                 SLC23A2* 
               
               
                 CITED2 
                 LUC7L2 
                 SLC24A6* 
               
               
                 CKAP2L 
                 LUM 
                 SLC25A24 
               
               
                 CKB 
                 LY6E 
                 SLC29A1* 
               
               
                 CKLF* 
                 MAFB 
                 SLC2A1* 
               
               
                 CLCA2* (includes EG: 9635) 
                 MAGOH 
                 SLC30A1* 
               
               
                 CLCN5* 
                 MALAT1 
                 SLC35A5 
               
               
                 CLDN8* 
                 MAN1A2 
                 SLC40A1* 
               
               
                 CLIC4 
                 MAP4K5 
                 SLC44A2* 
               
               
                 CLTC* 
                 MAPK6 
                 SLC4A4* 
               
               
                 CLU* 
                 MAPK14 
                 SLC4A7* 
               
               
                 CNN1 
                 MAPKAPK5 
                 SLC5A1* 
               
               
                 CNN2 
                 MAPRE2 
                 SLC6A6* 
               
               
                 CNTNAP2* 
                 MARCKSL1 
                 SLC9A2* 
               
               
                 COL18A1* 
                 MAST4 
                 SLC9A3R2* 
               
               
                 COL1A2* 
                 MBNL2 
                 SLCO2A1* 
               
               
                 COL3A1* 
                 MBTD1 
                 SMARCA2 
               
               
                 COL4A1* 
                 MCM4 
                 SMARCA4 
               
               
                 COL5A1* 
                 MCM6 
                 SMC4 
               
               
                 COL5A2* 
                 MCM10 
                 SMC6 
               
               
                 COL6A1* 
                 MDM4 
                 SMPDL3B* 
               
               
                 COPG2 
                 ME2 
                 SNAP23* 
               
               
                 COPZ2 (includes EG: 51226) 
                 MEF2A (includes EG: 4205) 
                 SNAPC3 
               
               
                 CORO1C 
                 MEIS1 
                 SNORD22 (includes EG: 9304) 
               
               
                 CORO2A 
                 MERTK* 
                 SNRPA1 
               
               
                 CPD* 
                 MFAP3L 
                 SNRPD1 
               
               
                 CPEB2 
                 MGP* 
                 SNX6 
               
               
                 CPSF3L 
                 MLLT4 
                 SNX25 
               
               
                 CREB3L2 
                 MLYCD 
                 SOCS3 
               
               
                 CREBL2 
                 MMGT1 
                 SOD1 
               
               
                 CRIM1* 
                 MMP2* 
                 SON 
               
               
                 CRIP1 
                 MOBKL1B* 
                 SORL1* 
               
               
                 CRISPLD2 (includes EG: 83716) 
                 MOCS1 
                 SORT1 
               
               
                 CROT 
                 MPZL1* 
                 SPARC* 
               
               
                 CRYZ 
                 MPZL2* 
                 SPARCL1* 
               
               
                 CRYZL1 
                 MRE11A 
                 SPHK1 
               
               
                 CSAD 
                 MRPL9 
                 SPIN1 
               
               
                 CSF1R* 
                 MRPS2 
                 SPON1* 
               
               
                 CSNK1A1 
                 MRPS23 
                 SPOP* 
               
               
                 CSNK1E 
                 MSH6 
                 SPTLC1 
               
               
                 CSRP1 
                 MSI2 
                 SRI 
               
               
                 CSTF2 (includes EG: 1478) 
                 MSRB3 (includes EG: 253827) 
                 SRRM2 
               
               
                 CTNNB1 
                 MTM1 
                 SSRP1 
               
               
                 CTNS 
                 MTMR2 
                 STAG2 
               
               
                 CTSD 
                 MTMR4 
                 STAM2 
               
               
                 CTSE 
                 MTMR6 
                 STAMBP 
               
               
                 CTTN* 
                 MTSS1 
                 STARD13 
               
               
                 CXADR* 
                 MTUS1 
                 STOX2 
               
               
                 CXCL14* 
                 MXI1 
                 SUB1 
               
               
                 CXCL16* 
                 MXRA8 
                 SULF1 
               
               
                 CYB5B 
                 MYCL1 
                 SUOX 
               
               
                 CYB5R3 
                 MYEF2 
                 SUPT16H 
               
               
                 CYFIP2 (includes EG: 26999) 
                 MYH11 
                 SYNJ2BP 
               
               
                 CYP1A1 
                 MYL9 (includes EG: 10398) 
                 SYNM 
               
               
                 CYP1B1 
                 MYLIP 
                 SYPL1* 
               
               
                 DAB1 
                 MYLK 
                 SYTL2 
               
               
                 DAB2* 
                 N6AMT1 
                 TAF15 
               
               
                 DALRD3 
                 NAB2 
                 TAGLN 
               
               
                 DAPK1 
                 NANS 
                 TAGLN2 
               
               
                 DBP 
                 NAP1L1 
                 TARDBP 
               
               
                 DCBLD2* 
                 NAPA 
                 TBC1D8* 
               
               
                 DCN* 
                 NAT11 
                 TBC1D9* 
               
               
                 DCTD 
                 NAV1 
                 TBX3 
               
               
                 DCXR 
                 NBEAL1 
                 TCF4 
               
               
                 DDX20 
                 NBR1 
                 TCF21 
               
               
                 DDX46 
                 NCAPG2 
                 TCF25 
               
               
                 DECR1 
                 NCAPH 
                 TCP11L2 
               
               
                 DECR2 
                 NDE1 
                 TCTA 
               
               
                 DEFB1* 
                 NDN 
                 TERF1 
               
               
                 DEGS1* 
                 NDRG1 
                 TFF1* 
               
               
                 DEPDC6 (includes EG: 64798) 
                 NEDD1 
                 TFRC* 
               
               
                 DGCR6* 
                 NEDD4 
                 TGFBI* 
               
               
                 DNA2 
                 NEDD4L 
                 TGM2 
               
               
                 DNAJA2 
                 NEK3 
                 THBS2* 
               
               
                 DNAJA4 
                 NET1 
                 THOC4 
               
               
                 DNAJB1 
                 NFAT5 
                 THRAP3 
               
               
                 DNAJC1 
                 NFIA 
                 TIMP2* 
               
               
                 DNAJC12 
                 NFIB 
                 TIPARP 
               
               
                 DNM2* 
                 NFIX 
                 TK2 
               
               
                 DNM1L 
                 NFKBIA 
                 TLR2 
               
               
                 DNMT3L 
                 NFKBIL2 
                 TMCC3 
               
               
                 DOCK8 
                 NFS1 
                 TMED2 
               
               
                 DOCK11 
                 NGFRAP1* 
                 TMEM8* 
               
               
                 DPT* 
                 NIPA1* 
                 TMEM33 
               
               
                 DR1 
                 NIPSNAP1 
                 TMEM49* 
               
               
                 DSC2* 
                 NISCH* 
                 TMEM57 
               
               
                 DSG2* 
                 NLK 
                 TMEM64 
               
               
                 DSP* 
                 NME4 
                 TMEM146 
               
               
                 DTNB* 
                 NONO 
                 TMEM184C 
               
               
                 DUSP1 
                 NOTCH1* 
                 TMPO 
               
               
                 DUSP16 
                 NQO1 
                 TMPRSS2* 
               
               
                 DVL1 
                 NRARP 
                 TMX4 
               
               
                 DYNLT3 
                 NRIP1 
                 TNC* 
               
               
                 DYRK1A 
                 NUBP1 
                 TNKS1BP1 
               
               
                 ECM1* 
                 NUCB2 
                 TNPO2 
               
               
                 EFEMP1* 
                 NUCKS1 
                 TNS1* 
               
               
                 EGLN3 
                 NUDCD1 
                 TOB2 
               
               
                 EGR1 
                 NUP35 
                 TOE1 
               
               
                 EHF 
                 NUP43 
                 TOP2B 
               
               
                 EID1 
                 NUP54 
                 TOPBP1 
               
               
                 EIF5 
                 NUP133 
                 TPI1 
               
               
                 EIF2AK1 
                 NUPL1 
                 TPM2 
               
               
                 EIF2AK2 
                 NUPR1 
                 TPMT 
               
               
                 EIF4A2 
                 OGT 
                 TPP1 
               
               
                 EIF4EBP2 
                 OLFM1 
                 TRAK1 
               
               
                 EIF4G1 
                 ORC1L 
                 TRIM2 
               
               
                 ELF3 
                 ORMDL3 
                 TRIO* 
               
               
                 ELF5 
                 OSBPL8 
                 TRIP13 
               
               
                 ELL2 
                 OSMR* 
                 TSC22D3 
               
               
                 ELOVL5 
                 OTUD4 
                 TSPAN6* 
               
               
                 EMD 
                 P2RX4* 
                 TSPAN7* 
               
               
                 EME1 
                 PABPN1 
                 TSPAN8* 
               
               
                 EMID1* 
                 PACS2 
                 TSSC4 
               
               
                 EMP1* 
                 PAFAH1B2 
                 TTC1 
               
               
                 EMP2* 
                 PAPOLA 
                 TTC14 
               
               
                 ENAH 
                 PAQR3 
                 TWF1 
               
               
                 ENPP5* 
                 PAQR5 
                 TWSG1* 
               
               
                 ENTPD5 
                 PAQR6 
                 TXLNA* (includes EG: 200081) 
               
               
                 EPHB2* 
                 PAQR7 
                 TXNIP 
               
               
                 EPHX1 
                 PAQR8* 
                 TYMP* 
               
               
                 EPHX3 
                 PARD3 
                 TYRO3* 
               
               
                 EPPK1 
                 PARP4 
                 UBAP2L 
               
               
                 EPSTI1 
                 PBX1 
                 UBE2B 
               
               
                 ERBB2IP* (includes EG: 55914) 
                 PCGF3 
                 UBE2H (includes EG: 7328) 
               
               
                 ERI1 
                 PCGF6 
                 UBE4B 
               
               
                 ERO1L 
                 PCMTD1 
                 UBTF 
               
               
                 ERRFI1 
                 PCMTD2 
                 UCHL1 
               
               
                 EXD1 
                 PCNA 
                 UGDH 
               
               
                 EXOSC6 
                 PCOLCE* 
                 UNC5A* 
               
               
                 EXT1 
                 PCYOX1 
                 UNC84A 
               
               
                 EZH2 
                 PDCD6IP 
                 UPK2* 
               
               
                 EZR* 
                 PDE2A 
                 UPK1B* 
               
               
                 F3* 
                 PDGFRA* 
                 USP1 
               
               
                 F2R* 
                 PDHA1 (includes EG: 5160) 
                 USP15 
               
               
                 F2RL1* 
                 PDK4 
                 USP32 
               
               
                 FABP4 
                 PDLIM5 
                 USP27X 
               
               
                 FADS2* 
                 PDZD2* 
                 VAMP3* 
               
               
                 FAF1 
                 PDZRN3* 
                 VAMP4 
               
               
                 FAR1 
                 PEG3 
                 VAPB* 
               
               
                 FBP1 
                 PELI1 
                 VEGFA* 
               
               
                 FBXL3 
                 PEX3 
                 VIM 
               
               
                 FBXO21 
                 PFDN4 
                 VLDLR* 
               
               
                 FBXW2 
                 PFDN5 
                 VNN1* 
               
               
                 FBXW7 
                 PFKFB3 
                 VPS35 
               
               
                 FBXW11 
                 PFKM 
                 VPS41 
               
               
                 FERMT2 
                 PFKP 
                 VRK1 
               
               
                 FETUB* 
                 PHF10 
                 WAC 
               
               
                 FGFR2* 
                 PHF13 
                 WBSCR27 
               
               
                 FHL1 
                 PHF17 
                 WDFY3 
               
               
                 FLOT2* 
                 PHKB 
                 WDR1* 
               
               
                 FMO2 
                 PHTF2 
                 WDR5 
               
               
                 FMO5 
                 PI16* 
                 WDR23 
               
               
                 FN1* 
                 PI4K2B 
                 WDR77 
               
               
                 FOXP2 
                 PI4KA 
                 WDR40B 
               
               
                 FRAS1* 
                 PIK3R1 
                 WEE1 
               
               
                 FSTL1* 
                 PIM3 
                 WHSC1 
               
               
                 FUBP1 
                 PIP4K2C 
                 WNK1 
               
               
                 FUSIP1 
                 PITPNB 
                 WNT5A* 
               
               
                 FUT9 
                 PKD2* (includes EG: 5311) 
                 WWTR1 
               
               
                 FXYD4 
                 PKP2* 
                 XIST 
               
               
                 FZD2* 
                 PLA2G6 
                 YIPF2 
               
               
                 FZD6* 
                 PLA2G7* 
                 YWHAH 
               
               
                 GADD45A 
                 PLA2R1* 
                 ZBTB20 
               
               
                 GADD45B 
                 PLAC8 
                 ZCCHC7 
               
               
                 GALNT6 
                 PLCH1 
                 ZDHHC9 
               
               
                 GALNT7 
                 PLDN 
                 ZFAND5 
               
               
                 GALNTL1 
                 PLEKHA2 
                 ZFAND6 
               
               
                 GARNL1 
                 PLEKHF2 (includes EG: 79666) 
                 ZFP62 
               
               
                 GARNL4 
                 PLK4 
                 ZFP91 
               
               
                 GAS6* 
                 PLS3 
                 ZFYVE27 
               
               
                 GATA6 
                 PLTP* 
                 ZMYM1 
               
               
                 GCNT1 
                 PMAIP1 
                 ZMYM6 
               
               
                 GCNT2 
                 PMEPA1* 
                 ZNF638 
               
               
                 GEM* 
                 PMP22* 
                 ZNHIT3 
               
               
                 GFRA3* 
                 PNN* 
               
               
                   
               
               
                 Note: 
               
               
                 Gene products previously reported to be cell surface or secreted proteins denoted with a “*” symbol 
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
             
             
               
                 ABCA1 
                 EFEMP1 
                 PROCR 
               
               
                 ABCA3 
                 EMID1 
                 PSAP 
               
               
                 ABCC3 
                 EPHB2 
                 PSCA (includes EG: 8000) 
               
               
                 ADAM10 
                 ERBB2IP (includes EG: 55914) 
                 PSEN1 
               
               
                 ADAM28 
                 EZR 
                 PTPRB 
               
               
                 ADAMDEC1 
                 F3 
                 PVRL2 
               
               
                 AMN 
                 F2R 
                 PVRL3 
               
               
                 ANK1 
                 F2RL1 
                 RARRES2 
               
               
                 ANTXR1 
                 FETUB 
                 RASA3 
               
               
                 ANXA6 
                 FGFR2 
                 RBP1 
               
               
                 APLP2 
                 FLOT2 
                 RHOC 
               
               
                 APOC1 
                 FN1 
                 RNASE4 
               
               
                 APP 
                 FRAS1 
                 RTN4 
               
               
                 AQP1 
                 FSTL1 
                 SDC1 
               
               
                 AQP3 
                 FZD2 
                 SDC2 
               
               
                 ATP1B1 
                 GAS6 
                 SDC4 
               
               
                 ATRN 
                 GFRA3 
                 SELE 
               
               
                 BCAM 
                 GNG10 
                 SERPING1 
               
               
                 BGN 
                 GPC4 
                 SH3GL2 
               
               
                 BST2 
                 GPX3 
                 SHH 
               
               
                 CACNA1H 
                 HTR4 
                 SLC12A2 
               
               
                 CAP1 
                 ICOSLG 
                 SLC12A6 
               
               
                 CAPRIN1 
                 IGF2 
                 SLC12A7 
               
               
                 CASK 
                 IGF1R 
                 SLC1A5 
               
               
                 CAV1 
                 IGFBP2 
                 SLC29A1 
               
               
                 CD44 
                 IGFBP4 
                 SLC2A1 
               
               
                 CD55 
                 IGFBP5 
                 SLC40A1 
               
               
                 CD99L2 
                 IGFBP6 
                 SLC44A2 
               
               
                 CELA1 
                 IL18 
                 SLC4A7 
               
               
                 CFD 
                 IL1RN 
                 SLC5A1 
               
               
                 CKLF 
                 IL6ST 
                 SNAP23 
               
               
                 CLTC 
                 KCNE1 
                 SORL1 
               
               
                 CLU 
                 KLK6 
                 SPARC 
               
               
                 CNTNAP2 
                 LCN2 
                 SPARCL1 
               
               
                 COL18A1 
                 LGALS1 
                 SYPL1 
               
               
                 COL1A2 
                 LGALS3 
                 TFF1 
               
               
                 COL3A1 
                 LIMS1 
                 TFRC 
               
               
                 COL4A1 
                 LRP1 
                 TGFBI 
               
               
                 COL5A1 
                 MERTK 
                 THBS2 
               
               
                 COL5A2 
                 MGP 
                 TIMP2 
               
               
                 COL6A1 
                 MMP2 
                 TMEM8 
               
               
                 CPD 
                 NISCH 
                 TMPRSS2 
               
               
                 CSF1R 
                 NOTCH1 
                 TNC 
               
               
                 CTTN 
                 P2RX4 
                 TRIO 
               
               
                 CXCL16 
                 PCOLCE 
                 TWSG1 
               
               
                 DAB2 
                 PDGFRA 
                 TXLNA (includes EG: 200081) 
               
               
                 DEFB1 
                 PDZD2 
                 TYMP 
               
               
                 DNM2 
                 PI16 
                 TYRO3 
               
               
                 DPT 
                 PLA2G7 
                 UPK2 
               
               
                 DSC2 
                 PLA2R1 
                 VAMP3 
               
               
                 DSG2 
                 PLTP 
                 VEGFA 
               
               
                 DSP 
                 PNN 
                 VLDLR 
               
               
                 ECM1 
                 PON3 
                 VNN1 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
             
           
               
                 TABLE 5 
               
               
                   
               
             
             
               
                 ABCA1 
                 EPHB2 
                 PSEN1 
               
               
                 ABCA3 
                 ERBB2IP (includes EG: 55914) 
                 PTPRB 
               
               
                 ABCC3 
                 EZR 
                 PVRL2 
               
               
                 ADAM10 
                 F2R 
                 PVRL3 
               
               
                 ADAM28 
                 F2RL1 
                 RARRES2 
               
               
                 ADAMDEC1 
                 FETUB 
                 RASA3 
               
               
                 AMN 
                 FGFR2 
                 RBP1 
               
               
                 ANK1 
                 FLOT2 
                 RHOC 
               
               
                 ANTXR1 
                 FRAS1 
                 RTN4 
               
               
                 ANXA6 
                 FSTL1 
                 SDC1 
               
               
                 APLP2 
                 FZD2 
                 SDC2 
               
               
                 APOC1 
                 GAS6 
                 SDC4 
               
               
                 APP 
                 GFRA3 
                 SELE 
               
               
                 AQP1 
                 GNG10 
                 SERPING1 
               
               
                 AQP3 
                 GPC4 
                 SH3GL2 
               
               
                 ATP1B1 
                 GPX3 
                 SHH 
               
               
                 ATRN 
                 HTR4 
                 SLC12A2 
               
               
                 BCAM 
                 ICOSLG 
                 SLC12A6 
               
               
                 BGN 
                 IGF1R 
                 SLC12A7 
               
               
                 BST2 
                 IGFBP2 
                 SLC1A5 
               
               
                 CACNA1H 
                 IGFBP4 
                 SLC29A1 
               
               
                 CAP1 
                 IGFBP6 
                 SLC2A1 
               
               
                 CAPRIN1 
                 IL18 
                 SLC40A1 
               
               
                 CASK 
                 IL1RN 
                 SLC44A2 
               
               
                 CD44 
                 IL6ST 
                 SLC4A7 
               
               
                 CD55 
                 KCNE1 
                 SLC5A1 
               
               
                 CD99L2 
                 KLK6 
                 SNAP23 
               
               
                 CELA1 
                 LCN2 
                 SORL1 
               
               
                 CFD 
                 LGALS3 
                 SPARC 
               
               
                 CKLF 
                 LIMS1 
                 SYPL1 
               
               
                 CLTC 
                 LRP1 
                 TFF1 
               
               
                 CLU 
                 MERTK 
                 TFRC 
               
               
                 CNTNAP2 
                 MMP2 
                 TGFBI 
               
               
                 COL18A1 
                 NISCH 
                 THBS2 
               
               
                 COL4A1 
                 NOTCH1 
                 TIMP2 
               
               
                 COL5A1 
                 P2RX4 
                 TMEM8 
               
               
                 CPD 
                 PCOLCE 
                 TMPRSS2 
               
               
                 CSF1R 
                 PDZD2 
                 TRIO 
               
               
                 CXCL16 
                 PI16 
                 TWSG1 
               
               
                 DAB2 
                 PLA2G7 
                 TXLNA (includes EG: 200081) 
               
               
                 DEFB1 
                 PLA2R1 
                 TYMP 
               
               
                 DNM2 
                 PLTP 
                 TYRO3 
               
               
                 DSC2 
                 PNN 
                 UPK2 
               
               
                 DSG2 
                 PON3 
                 VAMP3 
               
               
                 DSP 
                 PROCR 
                 VEGFA 
               
               
                 ECM1 
                 PSAP 
                 VLDLR 
               
               
                 EFEMP1 
                 PSCA (includes EG: 8000) 
                 VNN1 
               
               
                 EMID1 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
             
             
               
                   
               
               
                 (ELISA, values in U/ml) 
               
             
          
           
               
                 Patient 
                 visit 
                 AMFR 
                 RacGap 
                 RHAMM 
                 PCNA* 
               
               
                   
               
             
          
           
               
                 1754641 
                 BASELINE 
                 29.12 
                 0.74 
                 9.31 
                 0.00 
               
               
                 1754641 
                 EARLY 
                 32.57 
                 0.42 
                 10.27 
                 0.00 
               
               
                   
                 TERM 
               
               
                 1264555 
                 BASELINE 
                 9.30 
                 0.02 
                 0.98 
                 0.40 
               
               
                 344121 
                 BASELINE 
                 1.65 
                 0.00 
                 0.64 
                 0.02 
               
               
                 344121 
                 VISIT 4 
                 3.18 
                 0.05 
                 1.91 
                 0.00 
               
               
                 344121 
                 VISIT 6 
                 3.20 
                 0.06 
                 4.29 
                 0.00 
               
               
                 1334562 
                 BASELINE 
                 1.18 
                 1.07 
                 1.20 
                 0.00 
               
               
                 1334562 
                 VISIT 4 
                 3.97 
                 0.53 
                 2.06 
                 0.00 
               
               
                 1334562 
                 VISIT 6 
                 23.73 
                 0.44 
                 3.64 
                 0.02 
               
               
                 724459 
                 BASELINE 
                 22.53 
                 2.31 
                 19.20 
                 0.00 
               
               
                 724459 
                 VISIT 4 
                 8.77 
                 0.34 
                 5.08 
                 0.00 
               
               
                 724459 
                 VISIT 6 
                 1.60 
                 0.65 
                 5.68 
                 0.00 
               
               
                 674475 
                 BASELINE 
                 20.46 
                 1.85 
                 9.48 
                 0.00 
               
               
                 674475 
                 VISIT 4 
                 13.86 
                 0.49 
                 0.32 
                 0.00 
               
               
                 674475 
                 VISIT 6 
                 2.61 
                 0.50 
                 0.00 
                 0.00 
               
               
                 674475 
                 EARLY 
                 35.34 
                 4.47 
                 8.98 
                 0.00 
               
               
                   
                 TERM 
               
               
                 1254563 
                 BASELINE 
                 14.02 
                 1.40 
                 0.93 
                 0.00 
               
               
                 1254563 
                 VISIT 4 
                 1.13 
                 0.38 
                 0.00 
                 0.00 
               
               
                 1124730 
                 BASELINE 
                 12.32 
                 1.40 
                 6.79 
                 0.00 
               
               
                 1554559 
                 BASELINE 
                 13.57 
                 0.45 
                 14.24 
                 0.00 
               
               
                 1554559 
                 VISIT 4 
                 8.22 
                 0.64 
                 9.46 
                 0.00 
               
               
                 1424566 
                 BASELINE 
                 5.89 
                 0.15 
                 0.24 
                 0.14 
               
               
                 1424566 
                 VISIT 4 
                 21.70 
                 0.59 
                 1.53 
                 0.19 
               
               
                 1424566 
                 EARLY 
                 14.23 
                 1.00 
                 0.41 
                 0.18 
               
               
                   
                 TERM 
               
               
                 574382 
                 BASELINE 
                 3.11 
                 0.42 
                 13.45 
                 0.50 
               
               
                 574382 
                 EARLY 
                 27.29 
                 0.27 
                 3.78 
                 0.35 
               
               
                   
                 TERM 
               
               
                 584016 
                 BASELINE 
                 10.25 
                 0.06 
                 2.86 
                 0.21 
               
               
                 584016 
                 EARLY 
                 1.97 
                 0.17 
                 5.37 
                 0.22 
               
               
                   
                 TERM 
               
               
                 1504628 
                 BASELINE 
                 5.12 
                 0.85 
                 2.44 
                 0.15 
               
               
                 1504628 
                 EARLY 
                 2.14 
                 1.36 
                 11.27 
                 0.10 
               
               
                   
                 TERM 
               
               
                 1414602 
                 BASELINE 
                 34.16 
                 0.37 
                 0.08 
                 0.24 
               
               
                 1414602 
                 VISIT 4 
                 10.95 
                 0.60 
                 16.33 
                 0.18 
               
               
                 1414602 
                 VISIT 6 
                 0.88 
                 0.76 
                 4.10 
                 0.05 
               
               
                 364075 
                 BASELINE 
                 3.37 
                 0.02 
                 2.54 
                 0.51 
               
               
                 364075 
                 VISIT 4 
                 1.03 
                 0.00 
                 1.63 
                 0.17 
               
               
                 364075 
                 EARLY 
                 22.06 
                 0.44 
                 0.88 
                 0.00 
               
               
                   
                 TERM 
               
               
                 1474540 
                 BASELINE 
                 32.65 
                 0.36 
                 4.16 
                 0.11 
               
               
                 1474540 
                 VISIT 4 
                 2.97 
                 0.13 
                 0.87 
                 0.20 
               
               
                 1474540 
                 VISIT 6 
                 24.72 
                 0.58 
                 6.13 
                 0.19 
               
               
                 624329 
                 BASELINE 
                 6.19 
                 0.06 
                 0.59 
                 0.16 
               
               
                 624329 
                 VISIT 4 
                 3.63 
                 0.06 
                 0.49 
                 0.23 
               
               
                 624329 
                 VISIT 6 
                 7.60 
                 0.49 
                 1.40 
                 0.37 
               
               
                 984652 
                 BASELINE 
                 7.93 
                 0.54 
                 1.79 
                 0.09 
               
               
                 984652 
                 VISIT 4 
                 6.46 
                 0.35 
                 1.77 
                 0.04 
               
               
                 684479 
                 BASELINE 
                 7.58 
                 0.35 
                 2.27 
                 0.24 
               
               
                 684479 
                 VISIT 4 
                 9.23 
                 0.52 
                 2.53 
                 0.96 
               
               
                 684479 
                 VISIT 6 
                 1.57 
                 0.36 
                 0.12 
                 0.88 
               
               
                 684479 
                 EARLY 
                 1.44 
                 0.16 
                 1.06 
                 0.61 
               
               
                   
                 TERM 
               
               
                 694457 
                 BASELINE 
                 18.04 
                 0.30 
                 0.68 
                 0.21 
               
               
                 694457 
                 VISIT 4 
                 1.46 
                 0.04 
                 0.32 
                 0.35 
               
               
                 694457 
                 VISIT 6 
                 2.31 
                 0.03 
                 0.10 
                 0.18 
               
               
                 714474 
                 BASELINE 
                 6.24 
                 0.06 
                 0.13 
                 0.00 
               
               
                 714474 
                 VISIT 4 
                 0.00 
                 0.00 
                 0.17 
                 0.00 
               
               
                 714474 
                 VISIT 6 
                 40.73 
                 0.65 
                 1.61 
                 0.07 
               
               
                 804330 
                 BASELINE 
                 23.02 
                 0.08 
                 0.42 
                 0.23 
               
               
                 804330 
                 VISIT 4 
                 12.22 
                 0.04 
                 0.19 
                 0.51 
               
               
                 804330 
                 EARLY 
                 33.93 
                 0.18 
                 0.00 
                 0.26 
               
               
                   
                 TERM 
               
               
                 924546 
                 BASELINE 
                 7.51 
                 0.04 
                 0.94 
                 1.22 
               
               
                 924546 
                 VISIT 4 
                 1.99 
                 0.05 
                 0.64 
                 0.83 
               
               
                 924546 
                 VISIT 6 
                 1.78 
                 0.04 
                 1.21 
                 1.12 
               
               
                 1514504 
                 BASELINE 
                 5.75 
                 0.25 
                 6.42 
                 0.99 
               
               
                 1514504 
                 VISIT 4 
                 1.82 
                 0.02 
                 0.64 
                 0.80 
               
               
                 1514504 
                 EARLY 
                 3.50 
                 0.51 
                 6.52 
                 0.86 
               
               
                   
                 TERM 
               
               
                 174073 
                 BASELINE 
                 6.05 
                 0.30 
                 4.26 
                 0.71 
               
               
                 174073 
                 VISIT 4 
                 1.24 
                 0.13 
                 1.53 
                 0.74 
               
               
                 174073 
                 VISIT 6 
                 3.12 
                 0.19 
                 1.17 
                 0.62 
               
               
                 254017 
                 BASELINE 
                 0.98 
                 0.04 
                 0.94 
                 0.86 
               
               
                 254017 
                 VISIT 4 
                 6.11 
                 0.08 
                 2.59 
                 0.77 
               
               
                 254017 
                 VISIT 6 
                 10.75 
                 0.23 
                 8.75 
                 0.79 
               
               
                 424441 
                 BASELINE 
                 2.32 
                 0.15 
                 1.57 
                 0.71 
               
               
                 424441 
                 VISIT 4 
                 0.35 
                 0.19 
                 2.39 
                 1.02 
               
               
                 424441 
                 VISIT 6 
                 0.19 
                 0.15 
                 2.28 
                 1.18 
               
               
                 74012 
                 BASELINE 
                 0.58 
                 0.15 
                 2.49 
                 0.60 
               
               
                 74012 
                 VISIT 4 
                 0.88 
                 0.11 
                 1.35 
                 0.74 
               
               
                 74012 
                 VISIT 6 
                 0.18 
                 0.04 
                 0.60 
                 0.73 
               
               
                 124014 
                 BASELINE 
                 4.17 
                 0.10 
                 4.75 
                 0.06 
               
               
                 124014 
                 VISIT 4 
                 3.51 
                 0.13 
                 6.46 
                 0.05 
               
               
                 634417 
                 BASELINE 
                 0.19 
                 0.13 
                 1.67 
                 1.10 
               
               
                 634417 
                 VISIT 4 
                 1.27 
                 0.15 
                 3.26 
                 0.77 
               
               
                 634417 
                 VISIT 6 
                 4.93 
                 0.41 
                 4.98 
                 0.63 
               
               
                 634417 
                 EARLY 
                 2.45 
                 0.65 
                 6.57 
                 0.81 
               
               
                   
                 TERM 
               
               
                 664418 
                 BASELINE 
                 3.81 
                 0.00 
                 1.41 
                 0.75 
               
               
                 664418 
                 VISIT 4 
                 2.50 
                 0.08 
                 0.95 
                 1.42 
               
               
                 664418 
                 VISIT 6 
                 6.82 
                 0.16 
                 1.01 
                 1.02 
               
               
                 704332 
                 BASELINE 
                 12.31 
                 0.21 
                 0.29 
                 0.85 
               
               
                 704332 
                 VISIT 4 
                 0.00 
                 0.00 
                 0.04 
                 0.83 
               
               
                 704332 
                 VISIT 6 
                 6.02 
                 0.08 
                 0.34 
                 0.95 
               
               
                 1414602 
                 BASELINE 
                 1.22 
                 0.00 
                 0.04 
                 0.24 
               
               
                 1414602 
                 VISIT 4 
                 7.30 
                 0.05 
                 0.08 
                 0.18 
               
               
                 1414602 
                 VISIT 6 
                 13.83 
                 0.04 
                 0.17 
                 0.05 
               
               
                 14001 
                 BASELINE 
                 9.85 
                 0.06 
                 0.79 
                 0.56 
               
               
                 14001 
                 VISIT 4 
                 1.05 
                 0.04 
                 0.13 
                 0.55 
               
               
                 14001 
                 VISIT 6 
                 3.07 
                 0.07 
                 0.86 
                 0.62 
               
               
                 24002 
                 BASELINE 
                 0.77 
                 0.00 
                 0.00 
                 0.92 
               
               
                 24002 
                 VISIT 4 
                 5.91 
                 0.00 
                 0.73 
                 1.02 
               
               
                 24002 
                 VISIT 6 
                 1.25 
                 0.00 
                 0.00 
                 3.27 
               
               
                 1584532 
                 BASELINE 
                 0.67 
                 0.02 
                 1.66 
                 0.79 
               
               
                 1584532 
                 EARLY 
                 2.75 
                 0.21 
                 2.09 
                 0.79 
               
               
                   
                 TERM 
               
               
                 414082 
                 BASELINE 
                 13.19 
                 0.49 
                 3.69 
                 0.65 
               
               
                 414082 
                 VISIT 4 
                 1.12 
                 0.04 
                 0.59 
                 0.64 
               
               
                 414082 
                 VISIT 6 
                 3.63 
                 0.26 
                 1.12 
                 0.79 
               
               
                 194066 
                 BASELINE 
                 1.11 
                 0.07 
                 0.89 
                 0.57 
               
               
                 224070 
                 BASELINE 
                 3.49 
                 0.16 
                 2.52 
                 1.17 
               
               
                 164065 
                 BASELINE 
                 11.10 
                 0.37 
                 5.38 
                 0.33 
               
               
                 1494552 
                 BASELINE 
                 0.00 
                 0.00 
                 0.00 
                 0.82 
               
               
                 1494552 
                 VISIT 4 
                 2.64 
                 0.08 
                 0.46 
                 0.90 
               
               
                 1234754 
                 BASELINE 
                 4.93 
                 0.13 
                 0.75 
                 0.74 
               
               
                 1234754 
                 VISIT 4 
                 4.68 
                 0.25 
                 0.85 
                 1.24 
               
               
                 1234754 
                 VISIT 6 
                 11.00 
                 0.55 
                 3.68 
                 0.74 
               
               
                 1004538 
                 BASELINE 
                 27.79 
                 1.46 
                 6.00 
                 0.14 
               
               
                 864651 
                 BASELINE 
                 6.51 
                 0.42 
                 4.58 
                 1.44 
               
               
                 864651 
                 VISIT 4 
                 0.41 
                 0.03 
                 0.43 
                 0.73 
               
               
                 864651 
                 VISIT 6 
                 0.89 
                 0.04 
                 1.21 
                 0.84 
               
               
                 734667 
                 BASELINE 
                 4.94 
                 0.33 
                 4.06 
                 0.64 
               
               
                 734667 
                 VISIT 4 
                 9.92 
                 0.79 
                 4.72 
                 0.76 
               
               
                 734667 
                 VISIT 6 
                 21.99 
                 2.41 
                 20.47 
                 1.32 
               
               
                 744460 
                 BASELINE 
                 3.12 
                 0.11 
                 2.34 
                 1.24 
               
               
                 744460 
                 EARLY 
                 9.09 
                 0.08 
                 4.93 
                 1.02 
               
               
                   
                 TERM 
               
               
                 614380 
                 BASELINE 
                 3.34 
                 0.02 
                 0.20 
                 1.19 
               
               
                 614380 
                 VISIT 4 
                 0.33 
                 0.01 
                 0.00 
                 1.26 
               
               
                 614380 
                 VISIT 10 
                 1.61 
                 0.12 
                 1.81 
                 0.79 
               
               
                 614380 
                 VISIT 6 
                 0.07 
                 0.02 
                 0.15 
                 1.03 
               
               
                 1774764 
                 BASELINE 
                 9.52 
                 1.29 
                 8.08 
                 0.86 
               
               
                 1774764 
                 EARLY 
                 3.62 
                 0.95 
                 1.52 
                 0.72 
               
               
                   
                 TERM 
               
               
                 534316 
                 BASELINE 
                 8.69 
                 0.20 
                 5.02 
                 0.99 
               
               
                 534316 
                 VISIT 4 
                 7.46 
                 0.19 
                 2.98 
                 0.80 
               
               
                 534316 
                 VISIT 6 
                 9.07 
                 0.24 
                 5.38 
                 0.86 
               
               
                 454076 
                 BASELINE 
                 4.82 
                 0.19 
                 11.40 
                 1.49 
               
               
                 454076 
                 VISIT 4 
                 2.69 
                 0.12 
                 14.71 
                 0.99 
               
               
                 454076 
                 VISIT 6 
                 19.01 
                 0.16 
                 10.86 
                 0.68 
               
               
                 494313 
                 BASELINE 
                 9.03 
                 0.05 
                 6.21 
                 1.19 
               
               
                 494313 
                 VISIT 4 
                 5.98 
                 0.10 
                 14.15 
                 0.93 
               
               
                 494313 
                 VISIT 6 
                 3.56 
                 0.04 
                 9.65 
                 0.89 
               
               
                 1714661 
                 BASELINE 
                 1.75 
                 0.23 
                 1.48 
                 0.88 
               
               
                 1714661 
                 VISIT 4 
                 20.52 
                 1.34 
                 5.45 
                 1.54 
               
               
                 1714661 
                 EARLY 
                 9.40 
                 0.64 
                 3.41 
                 0.84 
               
               
                   
                 TERM 
               
               
                 1194537 
                 BASELINE 
                 7.77 
                 0.48 
                 2.38 
                 1.39 
               
               
                 1194537 
                 VISIT 4 
                 5.25 
                 0.47 
                 12.08 
                 1.06 
               
               
                 1194537 
                 VISIT 6 
                 1.82 
                 0.04 
                 1.95 
                 0.93 
               
               
                 1724660 
                 BASELINE 
                 0.84 
                 0.00 
                 0.00 
                 0.98 
               
               
                 1724660 
                 VISIT 4 
                 6.18 
                 0.49 
                 7.34 
                 1.07 
               
               
                 1724660 
                 EARLY 
                 1.79 
                 0.13 
                 1.46 
                 1.23 
               
               
                   
                 TERM 
               
               
                 464162 
                 BASELINE 
                 1.08 
                 0.23 
                 1.23 
                 0.84 
               
               
                 1174556 
                 BASELINE 
                 1.79 
                 0.36 
                 8.57 
                 0.97 
               
               
                 1174556 
                 EARLY 
                 1.11 
                 0.00 
                 1.51 
                 0.76 
               
               
                   
                 TERM 
               
               
                 1214554 
                 BASELINE 
                 6.21 
                 0.40 
                 2.95 
                 0.74 
               
               
                 1214554 
                 VISIT 4 
                 1.55 
                 0.80 
                 1.99 
                 0.62 
               
               
                 1214554 
                 VISIT 6 
                 0.16 
                 0.06 
                 0.33 
                 0.86 
               
               
                 1214554 
                 EARLY 
                 0.21 
                 0.00 
                 0.44 
                 0.74 
               
               
                   
                 TERM 
               
               
                 234067 
                 BASELINE 
                 0.58 
                 0.41 
                 1.42 
                 0.62 
               
               
                 234067 
                 VISIT 4 
                 3.31 
                 0.95 
                 4.77 
                 0.77 
               
               
                 1464557 
                 BASELINE 
                 11.83 
                 0.39 
                 1.24 
                 0.87 
               
               
                 1464557 
                 VISIT 4 
                 7.32 
                 0.16 
                 1.14 
                 0.86 
               
               
                 1464557 
                 VISIT 6 
                 2.09 
                 0.13 
                 1.31 
                 1.58 
               
               
                 1464557 
                 EARLY 
                 47.80 
                 1.34 
                 7.53 
                 0.93 
               
               
                   
                 TERM 
               
               
                 354129 
                 BASELINE 
                 0.37 
                 0.03 
                 0.28 
                 1.09 
               
               
                 354129 
                 EARLY 
                 9.75 
                 0.50 
                 3.72 
                 0.66 
               
               
                   
                 TERM 
               
               
                 1384501 
                 BASELINE 
                 0.30 
                 0.09 
                 0.45 
                 0.83 
               
               
                 1384501 
                 VISIT 4 
                 0.64 
                 0.19 
                 0.24 
                 1.29 
               
               
                 1384501 
                 VISIT 6 
                 0.96 
                 0.47 
                 0.29 
                 1.41 
               
               
                 704332 
                 BASELINE 
                 7.55 
                 1.31 
                 4.07 
                 0.85 
               
               
                 704332 
                 VISIT 4 
                 2.13 
                 1.11 
                 1.38 
                 0.83 
               
               
                 704332 
                 VISIT 6 
                 1.61 
                 0.44 
                 1.03 
                 0.95 
               
               
                 514461 
                 BASELINE 
                 1.39 
                 0.16 
                 1.46 
                 0.20 
               
               
                 514461 
                 VISIT 4 
                 11.78 
                 0.27 
                 1.69 
                 0.31 
               
               
                 514461 
                 EARLY 
                 9.04 
                 0.27 
                 1.21 
                 0.74 
               
               
                   
                 TERM 
               
               
                 504282 
                 BASELINE 
                 3.35 
                 0.10 
                 0.55 
                 0.93 
               
               
                 504282 
                 VISIT 4 
                 7.28 
                 0.53 
                 1.62 
                 0.85 
               
               
                 504282 
                 VISIT 6 
                 8.55 
                 0.24 
                 2.81 
                 0.89 
               
               
                 604384 
                 BASELINE 
                 1.29 
                 0.61 
                 3.71 
                 1.00 
               
               
                 604384 
                 VISIT 4 
                 1.49 
                 0.46 
                 5.19 
                 1.14 
               
               
                 604384 
                 VISIT 6 
                 2.00 
                 0.55 
                 6.54 
                 0.92 
               
               
                 604384 
                 VISIT 10 
                 0.32 
                 0.07 
                 1.91 
                 1.24 
               
               
                 44010 
                 BASELINE 
                 1.17 
                 0.34 
                 3.81 
                 1.12 
               
               
                 44010 
                 VISIT 4 
                 1.85 
                 0.44 
                 7.15 
                 0.93 
               
               
                 44010 
                 VISIT 6 
                 1.75 
                 0.36 
                 7.29 
                 0.97 
               
               
                 1564560 
                 BASELINE 
                 1.23 
                 0.13 
                 7.57 
                 1.05 
               
               
                 1564560 
                 VISIT 4 
                 5.35 
                 0.30 
                 10.77 
                 0.94 
               
               
                 1564560 
                 VISIT 6 
                 1.76 
                 0.01 
                 1.45 
                 0.83 
               
               
                 1464557 
                 BASELINE 
                 10.10 
                 0.03 
                 1.34 
               
               
                 1464557 
                 VISIT 4 
                 1.62 
                 0.00 
                 1.94 
               
               
                 1464557 
                 VISIT 6 
                 0.93 
                 0.02 
                 0.45 
               
               
                 1464557 
                 EARLY 
                 5.19 
                 0.75 
                 15.41 
               
               
                   
                 TERM 
               
               
                 354129 
                 BASELINE 
                 0.90 
                 0.14 
                 0.62 
               
               
                 354129 
                 EARLY 
                 4.36 
                 0.18 
                 4.76 
               
               
                   
                 TERM 
               
               
                 1214554 
                 BASELINE 
                 7.10 
                 0.24 
                 5.64 
               
               
                 1214554 
                 VISIT 4 
                 9.90 
                 0.48 
                 3.94 
               
               
                 1214554 
                 VISIT 6 
                 1.40 
                 0.03 
                 1.26 
               
               
                 1214554 
                 EARLY 
                 0.44 
                 0.06 
                 1.23 
               
               
                   
                 TERM 
               
               
                 1174556 
                 BASELINE 
                 10.80 
                 0.43 
                 6.94 
               
               
                 1174556 
                 EARLY 
                 4.91 
                 0.03 
                 0.60 
               
               
                   
                 TERM 
               
               
                 1594673 
                 BASELINE 
                 1.42 
                 0.26 
                 1.49 
               
               
                 1594673 
                 EARLY 
                 0.22 
                 0.02 
                 2.13 
               
               
                   
                 TERM 
               
               
                 974547 
                 BASELINE 
                 1.20 
                 0.35 
                 3.51 
               
               
                 974547 
                 VISIT 4 
                 5.55 
                 0.12 
                 4.53 
               
               
                 974547 
                 EARLY 
                 10.94 
                 0.27 
                 40.32 
               
               
                   
                 TERM 
               
               
                 1064548 
                 BASELINE 
                 8.46 
                 0.20 
                 15.16 
               
               
                 1644712 
                 BASELINE 
                 4.60 
                 0.31 
                 30.45 
               
               
                 644163 
                 BASELINE 
                 10.48 
                 0.25 
                 30.84 
               
               
                 644163 
                 VISIT 4 
                 1.08 
                 0.09 
                 12.70 
               
               
                 644163 
                 VISIT 6 
                 1.12 
                 0.02 
                 12.77 
               
               
                 264068 
                 BASELINE 
                 5.26 
                 0.21 
                 29.30 
               
               
                 934578 
                 BASELINE 
                 5.35 
                 0.25 
                 16.97 
               
               
                 934578 
                 VISIT 4 
                 1.50 
                 0.07 
                 7.31 
               
               
                 934578 
                 VISIT 6 
                 3.47 
                 0.24 
                 13.23 
               
               
                 314074 
                 BASELINE 
                 9.01 
                 4.16 
                 12.96 
               
               
                 314074 
                 VISIT 4 
                 7.73 
                 2.07 
                 23.12 
               
               
                 314074 
                 VISIT 6 
                 6.65 
                 0.73 
                 34.34 
               
               
                 204007 
                 BASELINE 
                 16.72 
                 4.60 
                 40.41 
               
               
                 204007 
                 VISIT 4 
                 4.19 
                 0.42 
                 41.51 
               
               
                 204007 
                 VISIT 6 
                 5.71 
                 1.03 
                 54.74 
               
               
                 754476 
                 BASELINE 
                 0.76 
                 0.67 
                 22.90 
               
               
                 1374564 
                 BASELINE 
                 0.02 
                 0.18 
                 1.07 
               
               
                 1374564 
                 VISIT 4 
                 0.30 
                 0.20 
                 1.15 
               
               
                 844507 
                 BASELINE 
                 2.25 
                 0.64 
                 30.29 
               
               
                 64011 
                 BASELINE 
                 7.72 
                 1.22 
                 21.90 
               
               
                 64011 
                 EARLY 
                 4.52 
                 0.40 
                 6.82 
               
               
                   
                 TERM 
               
               
                 1454550 
                 BASELINE 
                 1.58 
                 0.80 
                 1.89 
               
               
                 1454550 
                 EARLY 
                 2.88 
                 0.90 
                 3.71 
               
               
                   
                 TERM 
               
               
                 1604793 
                 BASELINE 
                 3.15 
                 1.12 
                 5.68 
               
               
                 1604793 
                 VISIT 4 
                 2.38 
                 1.20 
                 5.17 
               
               
                 1614551 
                 BASELINE 
                 3.85 
                 0.60 
                 3.09 
               
               
                 274234 
                 BASELINE 
                 4.51 
                 1.22 
                 8.14 
               
               
                 1094654 
                 BASELINE 
                 1.00 
                 0.54 
                 2.48 
               
               
                 1094654 
                 VISIT 4 
                 1.81 
                 0.76 
                 6.11 
               
               
                 1094654 
                 VISIT 6 
                 1.24 
                 0.52 
                 6.09 
               
               
                 54006 
                 BASELINE 
                 4.09 
                 2.03 
                 11.16 
               
               
                 54006 
                 VISIT 4 
                 1.51 
                 0.70 
                 2.74 
               
               
                 54006 
                 VISIT 6 
                 0.29 
                 0.21 
                 0.86 
               
               
                 84081 
                 BASELINE 
                 2.38 
                 0.44 
                 3.30 
               
               
                 84081 
                 VISIT 4 
                 4.67 
                 1.88 
                 9.06 
               
               
                 84081 
                 VISIT 6 
                 2.66 
                 1.10 
                 2.16 
               
               
                 384083 
                 BASELINE 
                 0.61 
                 0.33 
                 1.08 
               
               
                 384083 
                 VISIT 4 
                 1.87 
                 0.60 
                 1.91 
               
               
                 334131 
                 BASELINE 
                 3.68 
                 0.58 
                 3.82 
               
               
                 1704761 
                 BASELINE 
                 3.74 
                 0.88 
                 5.04 
               
               
                 1434706 
                 BASELINE 
                 3.80 
                 1.19 
                 2.18 
               
               
                 1434706 
                 EARLY 
                 0.70 
                 0.19 
                 1.06 
               
               
                   
                 TERM 
               
               
                 964625 
                 BASELINE 
                 1.19 
                 0.40 
                 0.88 
               
               
                 964625 
                 EARLY 
                 1.34 
                 0.48 
                 1.56 
               
               
                   
                 TERM 
               
               
                 834649 
                 BASELINE 
                 1.03 
                 0.49 
                 1.52 
               
               
                 834649 
                 VISIT 6 
                 2.83 
                 0.87 
                 4.29 
               
               
                 94042 
                 BASELINE 
                 1.12 
                 0.24 
                 0.62 
               
               
                 94042 
                 VISIT 4 
                 1.72 
                 0.63 
                 1.40 
               
               
                 884633 
                 VISIT 4 
                 2.76 
                 1.38 
                 3.26 
               
               
                 884633 
                 VISIT 6 
                 3.39 
                 1.18 
                 3.83 
               
               
                 1634577 
                 BASELINE 
                 21.09 
                 0.42 
                 6.76 
               
               
                 1744558 
                 BASELINE 
                 33.76 
                 0.78 
                 14.15 
               
               
                 1744558 
                 VISIT 6 
                 24.90 
                 0.53 
                 8.29 
               
               
                 1744558 
                 EARLY 
                 39.77 
                 0.75 
                 15.31 
               
               
                   
                 TERM 
               
               
                 1074553 
                 BASELINE 
                 6.35 
                 0.10 
                 1.79 
               
               
                 1074553 
                 VISIT 6 
                 65.84 
                 0.93 
                 20.57 
               
               
                 1784817 
                 BASELINE 
                 67.22 
                 1.03 
                 22.22 
               
               
                 1784817 
                 VISIT 4 
                 49.11 
                 0.80 
                 20.62 
               
               
                 1104561 
                 BASELINE 
                 14.50 
                 0.49 
                 4.31 
               
               
                 1104561 
                 EARLY 
                 6.32 
                 0.13 
                 2.55 
               
               
                   
                 TERM 
               
               
                 654458 
                 BASELINE 
                 35.77 
                 0.52 
                 14.33