Abstract:
The invention relates to alternating copolymers having the formula ##STR1## wherein one of R 1 , R 2 , and R 3  in each repeating unit is hydrogen and the others of R 1 , R 2 , and R 3  in each repeating unit are CN or COOR 5 , wherein R5 is C 1  -C 8  alkyl; and n is from 10 to 5,000. This invention further relates to a process for preparing such alternating copolymers by copolymerization of appropriate alkenyl isocyanates and electron deficient olefins.

Description:
BACKGROUND OF THE INVENTION 
     The present invention relates to alternating copolymers of alkenyl isocyanates and electron deficient olefins, a process for their preparation, and a method of their use. 
     Alternating copolymers of alkenyl isocyanates and electron deficient olefins have not previously been described in the literature. Homopolymerization of higher alkenyl isocyantes gives polymers with only a low degree of polymerization. 
     The object was to provide polymers from alkenyl isocyantes with a high degree of polymerization and which, if appropriate, contain groups of different reactivity that can react independently of one another. 
     SUMMARY OF THE INVENTION 
     The invention relates to alternating copolymers having the formula ##STR2## wherein the &#34;R is hydrogen. C 1  -C 6  alkyl, or (C 1  -C 6  alkyl) (C 1  -C 6  alkane) carboxylate 
     one of R 1 , R 2 , and R 3  in each repeating unit is hydrogen and the others of R 1 , R 2 , and R 3  in each repeating unit are CN or COOR 5 , wherein R 5  is C 1  -C 8  alkyl; and 
     n is from about 10 to about 5,000; 
     &#34;R 4  is --(O═C)--O--(C═O)-- or --(O ═C)--NH--(C═O)--; 
     wherein said alternating copolymers are copolymerization products of 
     (a) alkenyl isocyantes of the formula ##STR3##  wherein R is hydrogen, C 1  -C 6  alkyl, or (C 1  -C 6  alkyl) (C 1  -C 6  alkane)carboxylate, and 
     (b) electron deficient olefins of the formula ##STR4##  wherein one of R 1 , R 2 , and R 3  is hydrogen and the others of R 1 , R 2 , and R 3  are CN or COOR 5 , wherein R 5  is C 1  -C 8  alkyl; or ##STR5##  wherein R 4  is --(O═C)--O--(C═O)-- or --(O═C)--NH--(C═O)--. 
     The invention further relates to a process for the preparation of these alternating copolymers comprising copolymerizing at a temperature between 0° and 100° C. in the presence of initiators 
     (a) alkenyl isocyanates of the formula ##STR6##  wherein R is hydrogen, C 1  -C 6  alkyl, or (C 1  -C 6  alkyl) (C 1  -C 6  alkane) carboxylate, 
     with 
     (b) electron deficient olefins of the formula ##STR7##  wherein one of R 1 , R 2 , and R 3  is hydrogen and the others of R 1 , R 2 , and R 3  are CN or COOR 5 , wherein R 5  is C 1  -C 8  alkyl; or ##STR8##  wherein R 4  is --(O═C)--O--(C═O)-- or --(O═C)--NH--(C═O)--. 
     DETAILED DESCRIPTION OF THE INVENTION 
     Preferred alternating copolymers are those in which the alkenyl isocyanate component is isopropenyl isocyanate, vinyl isocyanate, or alkyl 4-isocyanato-4-pentenoates and the electron deficient olefin component is maleic anhydride, maleimide, fumaric acid dinitrile, maleic acid dinitrile, maleic dialkyl esters, fumaric dialkyl esters, or cyanoacrylic alkyl esters. Particularly preferred alternating copolymers are those in which the electron deficient olefin component is maleic anhydride. 
     In the process according to the invention, the copolymerization is preferably carried out in bulk, in solution, or by precipitation polymerization. In a particularly preferred embodiment, copolymerization is carried out at temperatures between 0° C. and 80° C. Preferred initiators include aliphatic azo compounds, peroxides, or known redox initiators: 
     (4-methoxy-phenylazo)-methyl-malonic acid dinitrile 
     
         CH.sub.3 O--C.sub.6 H.sub.4 --N═N--C(CH.sub.3) (CN).sub.2 
    
     Bis-(1-acetoxy-1-phenyl-ethyl)-diazene 
     
         C.sub.6 H.sub.5 --C(CH.sub.3) (OC (O)CH.sub.3) --N═N(CH.sub.3 C(O)O) (CH.sub.3)C--C.sub.6 H.sub.5 
    
     Diphenylmethyl-(1-phenyl-ethyl)-diazene 
     
         HC(CH.sub.3)(C.sub.6 H.sub.5) --N═N--CH(C.sub.6 H.sub.5).sub.2 
    
     Bis-(1-acetoxy-1-alkyl-alkyl)-diazene 
     
         [R.sup.1 R.sup.2 C(OC(O)CH.sub.3)].sub.2 N.sub.2 
    
     unsym. 1-Acetoxy-phenylazo-alkane 
     
         C.sub.6 H.sub.5 --N═NCR.sup.1 R.sup.2 (OC(O)CH.sub.3) 
    
     Azo-bis-isobutane acid-dialkylester 
     
         [(CH.sub.3).sub.2 C(COOR)].sub.2 N.sub.2 
    
     peroxides 
     
         CH.sub.3 --C(O)--O--O--SO.sub.2 --C.sub.6 H.sub.11 
    
     
         [R--O--C(O)].sub.2 O.sub.2 
    
     
         [Cl.sub.2 C.sub.6 H.sub.3 --C(O)].sub.2 O.sub.2 
    
     
         (CH.sub.3).sub.3 C--C(O)--O--O--C(CH.sub.3).sub.3 
    
     
         [C.sub.11 H.sub.23 --C(O)].sub.2 O.sub.2 
    
     
         [C.sub.6 H.sub.5 --C(O)].sub.2 O.sub.2 
    
     
         C.sub.6 H.sub.5 --C(O)--O--O--C(CH.sub.3).sub.3 
    
     
         [C.sub.6 H.sub.5 --C(CH.sub.3).sub.2 ].sub.2 O.sub.2 
    
     and redox initiators 
     dibenzoylperoxide/FeSO 4   
     dibenzoylperoxide / 2-oxo-propanol 
     
         S.sub.2 O.sub.8.sup.2- / HSO.sub.3.sup.- 
    
     These alternating copolymers can be used, inter alia, as crosslinking agents for epoxides, polyhydroxy compounds, and diamines in the preparation of crosslinked polymers. 
     The alternating copolymers of the invention can also be used as carriers for the delivery of medicaments to mammalian patients. 
     The copolymerization of , for example, isopropenyl isocyanate, methyl 4-isocyanato-4-pentenoate, or vinyl isocyanate with maleic anhydride leads to high yields of alternating copolymers having highly reduced viscosities. The molar ratio of the monomers used in the reaction mixture can be varied within wide limits, for example, from about 1:5 to about 5:1. Even when the monomers are not used in equimolar quantities, the reaction can be conducted with high conversions (that is, almost complete incorporation of the monomer present in the smaller amount) without the alternating sequence in the polymer being affected. Copolymerization using an equimolar ratio of the two monomers is preferred. The polymerization can be carried out, for example, in bulk, in solution, or by precipitation polymerization from a 10% solution in benzene. 
     The two reactive groups of the unsaturated monomers are stable under the reaction conditions and in the isolated polymers. This stability is surprising because the known reaction between the isocyanate and anhydride groups would have been expected to take place to at least a certain degree and would have led to crosslinked products. 
     The following example further illustrate details for the preparation of the compositions of this invention. The invention, which is set forth in the foregoing disclosure, is not to be limited either in spirit or scope by these examples. Those skilled in the art will readily understand that known variations of the conditions and processes of the following preparative procedures can be used to prepare these compositions. Unless otherwise noted, all temperatures are degrees Celsius and all percentages are percentages by weight. 
    
    
     EXAMPLES 
     Example 1 
     Synthesis of alternating copolymers of isopropenyl isocyanate and maleic anhydride by precipitation polymerization 
     A mixture of 20 ml of benzene, 1.04 g (12.5 mmol) of isopropenyl isocyanate, 1.19 g (12.5 mmol) of maleic anhydride, and 20.4 mg (0.12 mol) of azodiisobutyronitrile (&#34;AIBN&#34;) is stirred at 60° C. for 10 hours in a 50 ml flask that has been heated thoroughly in vacuo and then cooled under argon. The polymer starts to precipitate out of the pale yellowcolored solution after about one hour. After ten hours, the precipitate is suction filtered using a fritted glass funnel under an inert gas, rinsed with benzene, and dried at 40° C. under an oil-pump vacuum. 
     Yield: 1.96 g (88%) 
     IR (film from acetone): 2270, 1850 and 1780 cm -1   
     Elemental analysis: C, H, and N&lt;0.1% from calculated values 
     Intrinsic viscosity: 0.44 dl/g (in acetone at 0.264 g/dl) 
     Examples 2-12 
     Synthesis of alternating copolymers (general procedure) 
     The procedure is generally as described under Example 1. The comonomers and AIBN (0.5 mol %, based on the maximum substance which can be polymerized) are weighed out in the molar ratio given in Tables 1-4 and dissolved in benzene, the solution is degassed, and polymerization is carried out 60° C. After the time given in the tables, the precipitated polymer is suction filtered using a fritted glass funnel under an inert gas. The product is extracted by stirring again in benzene and then dried under an oil-pump vacuum. 
     General properties of the polymers synthesized are as follows: 
     Solubility: The polymers are soluble in acetone, 2-butanone (methyl ethyl ketone), N,N-dimethylformamide, and N,N-dimethylacetamide. 
     IR spectra: Clear films of the polymers, which become cloudy on prolonged standing in air (15-30 min), are obtained from an acetone solution. The IR spectra of these films exhibit bands characteristic of the particular structural elements they contain: 
     Isocyanate 2270 cm -1   
     Methyl ester 1740 cm -1   
     Anhydride 1780 cm -1 , 1850 cm -1   
     Nitrile 2270 cm -1  (overlapped by the isocyanate) 
     
                       TABLE 1______________________________________Composition and properties of alternating copolymers of2-isocyanato-propene and maleic anhydride ##STR9##Ex-           Reactionample Molar   time     Yield.sup.(b)                        η.sup.(c)                              .sup.1 H-NMRNo.   ratio.sup.(a)         (hr)     (%)   (dl/g)                              (ppm)______________________________________1     1:1     8        88    0.44  3.8 (CH, anhydride)2     1:3     15       80    0.31  2.8 (CH.sub.2)3     3:1     15       71    0.30  2.0 (CH.sub.3).sup.(d)4     1:2     24       90    0.265     2:1     24       93    0.43______________________________________ .sup.(a) Isocyanate:maleic anhydride .sup.(b) Based on complete conversion of the component present in the lower amount .sup.(c) η denotes intrinsic viscosity .sup.(d) partly overlapped by acetone (solvent) 
    
     
                       TABLE 2______________________________________Composition and properties of alternating copolymers of methyl4-isocyanato-4-pentenoate and maleic anhydride ##STR10##Ex-           Reactionample Molar   time     Yield.sup.(b)                        η.sup.(c)                              .sup.1 H-NMRNo.   ratio.sup.(a)         (hr)     (%)   (dl/g)                              (ppm)______________________________________6     1:1     42       29    0.17  3.7 (CH, anhydride)7     1:3     42       25    0.18  3.6 (CH.sub.3); 2.6 (CH.sub.2)8     3:1     42       15    0.17______________________________________ .sup.(a) Isocyanate:maleic anhydride .sup.(b) Based on complete conversion of the component present in the lower amount .sup.(c) η denotes intrinsic viscosity 
    
     
                       TABLE 3______________________________________Composition and properties of alternating copolymers ofisocyanato-ethane and maleic anhydride ##STR11##Ex-           Reactionample Molar   time     Yield.sup.(b)                        η.sup.(c)                              .sup.1 H-NMRNo.   ratio.sup.(a)         (hr)     (%)   (dl/g)                              (ppm)______________________________________9     1:1     15       93    0.17  4.7 (CH, isocyanate)10    1:3     42       25    0.18  3.6 (CH, isocyanate)11    3:1     42       15    0.17  2.5 (CH.sub.2)______________________________________ .sup.(a) Isocyanate:maleic anhydride .sup.(b) Based on complete conversion of the component present in the lower amount .sup.(c) η denote intrinsic viscosity 
    
     
                       TABLE 4______________________________________Composition and properties of alternating copolymers ofisocyanato-propene and fumaric acid dinitrile ##STR12##Ex-           Reactionample Molar   time     Yield.sup.(b)                        η.sup.(c)                              .sup.1 H-NMRNo.   ratio.sup.(a)         (hr)     (%)   (dl/g)                              (ppm)______________________________________12    1:1     24       31    0.14  3.9 (CH); 2.5 (CH.sub.2)                              2.0 (CH.sub.3).sup.(d)______________________________________ .sup.(a) Isocyanate:fumaric acid dinitrile .sup.(b) Based on complete conversion of the component present in the lower amount .sup.(c) η denotes intrinsic viscosity .sup.(d) Partly overlapped by acetone (solvent)