Abstract:
An in vivo screening assay for identifying an agent that interferes with T cell activation and/or -differentiation and/or modulation of other inflammatory effector cells.

Description:
TECHNICAL FIELD OF THE INVENTION 
   The present invention relates in general to mode-locked lasers. The invention relates in particular to quasi-continuous-wave laser apparatus including a mode-locked laser delivering fundamental radiation that is externally frequency-converted by one or more optically nonlinear crystals 
   DISCUSSION OF BACKGROUND ART 
   Continuous wave (CW) and quasi-CW UV lasers have been successfully utilized in microelectronic fabrication operations, for example, for inspection of wafers, microcircuits and masks. An advantage of using UV wavelengths is that a spatial resolution can be achieved that is comparable to the feature size of circuits. A CW laser is preferable, as such a laser provides the highest average power, power which is necessary for high throughput of the operation, while exposing a sample being operated on to the lowest possible peak intensity. The lower peak intensity is desirable in order to reduce damage to the sample during the operation. 
   CW UV lasers having adequate average power (several Watts) are not commercially available. There are commercial UV lasers available that involve frequency converting the output of a so-called quasi-CW laser. Such a laser is a pulsed laser that operates at a very high pulse-repetition frequency (PRF), for example, greater than about 10 megahertz (MHz) and typically 50 or more MHz. The pulse repetition frequency can be sufficiently high that, in certain operations on certain targets, the pulsed radiation beam from such a laser can be regarded as a continuous beam. Lasers including neodymium (Nd) doped host crystals, in particular yttrium vanadate (YVO 4 ) or yttrium aluminum garnet (YAG) can be operated, mode-locked, at a PRF between 70 MHz and 120 MHz, with a pulse-duration of between about 10 and several 100 picoseconds. Such lasers have a fundamental output-wavelength of about 1064 nanometers (nm). This wavelength can be tripled, quadrupled, or quintupled by optically nonlinear crystals to provide, respectively, third-harmonic, fourth-harmonic, or fifth-harmonic, radiation, all of which are at UV-wavelengths. Having short (picosecond) pulses with relatively high peak-power facilitates frequency conversion into the UV range. By way of example, a Paladin™ (frequency-tripled Nd:YVO 4 ) model laser available from Coherent®, Inc. of Santa Clara, Calif., the assignee of the present invention, can provide, at a wavelength of 355 nm (the third-harmonic wavelength), an average power as high as about 8 Watts (W) at a PRF of about 80 MHz. Pulse-duration (FWHM) is about 15 picoseconds. 
   While a relatively high peak-power of fundamental-wavelength pulses is advantageous for frequency (wavelength) conversion of the fundamental radiation, a relatively high power for UV-radiation pulses so produced can be disadvantageous for reasons discussed above. An increased average power for the UV radiation pulses, however, would be advantageous for increased operation throughput. 
   One approach to reducing peak-power in the UV radiation is to increase the PRF of the frequency-converted pulses by using a pulse-dividing arrangement to divide an original pulsed beam into two or more new pulsed beams, temporally separated by a submultiple (one-half, one-third, one-fourth, etc) of the repetition period of the original pulsed beam, then recombine these new beams on a common path or on a target. The pulses in the recombined beam will have a fraction of the peak-power of pulses in the original beam but will be delivered at a higher (twice, three-times, four times) PRF than those in the original beam. The average power in the new beam will be the same as that in the original beam less any losses incurred in the dividing and recombining operations. Examples of this approach are described in U.S. Pat. No. 6,275,514. Pulses in such a recombined beam will also, however, have only a fraction of the energy of pulses in the original beam. This could be a problem in operations for which pulse energy must exceed a threshold value. 
   Another approach to reducing peak-power in pulses without significantly reducing energy in the pulses is to temporally “stretch” the pulses without effectively changing the pulse-repetition frequency. In this approach, an optical delay loop having a round-trip time on the order of the duration of the original pulse is used to divide an original pulse into a plurality of replica pulses temporally spaced apart, peak to peak, by about one or two pulse-durations of the original pulse. These replicas of the original pulse are recombined on a target or along a common path as discussed above. The close temporal spacing of the replica pulses provides that the effect of the replica pulses in most operations is the same as a single pulse having an energy equal to the sum of the energy in the replica pulses. It is for this reason that the combination of the replica pulses is usually referred to in the prior-art as a stretched pulse. 
   This pulse-stretching approach is commonly used to reduce peak-power in UV radiation pulses delivered by excimer lasers. Such pulses have a duration of between about 20 nanoseconds (ns) and 80 ns and are usually delivered at a PRF between 100 Hertz (Hz) and 5 kilohertz (kHz). Examples of this approach to stretching excimer-laser pulses are taught in U.S. Patent Publication No. 2006/0216037 and in U.S. Pat. No. 7,035,012, which are assigned to the assignee of the present invention. Examples are also taught in U.S. Pat. No. 6,535,531. Imaging delay loops described in these documents have a round-trip length of about 6 meters or greater, depending on the duration of pulses being stretched. In most examples described, reflective imaging optics “fold” the delay loops into a space having a length as short about one-fourth of the round-trip length 
   Mode-locked lasers described above, however, provide pulses having a duration of only several picoseconds. A delay line in accordance with the teachings of the above-reference documents, for a 15-picosecond pulse, would be required to have a length of only about 4.5 millimeters. Making and aligning components for an imaging delay line of this short length is impractical. Accordingly, there is a need for a different approach to stretching multi-picosecond pulses from frequency-converted mode-locked lasers. 
   SUMMARY OF THE INVENTION 
   The present invention is directed to laser apparatus for providing quasi-CW harmonic-wavelength pulses of relatively high average power and relatively low peak power. In one aspect, apparatus in accordance with the present invention comprises a laser source providing optical pulses having a first wavelength and being temporally equispaced by a pulse-repetition period τ and delivered at a pulse-repetition frequency (PRF) equal to 1/τ. An optical delay loop is arranged to receive the first-wavelength optical pulses and divide each thereof into a plurality of replicas thereof with the replicas of each pulse being temporally spaced apart by τ/N±Δτ, where N is an integer equal to or greater than 1 and Δτ is a about equal to or greater than the pulse-duration of the first-wavelength optical pulses. The optical delay loop is further arranged to deliver bursts of the pulse-replicas at a burst-repetition frequency equal to the PRF of the optical pulses multiplied by N, with each burst including replicas of different ones of the first-wavelength optical pulses. 
   In a preferred embodiment of apparatus in accordance with the present invention, the optical delay loop is the first of two optical delay loops and is arranged with N equal to 2 such that the bursts of pulse-replicas are delivered at a burst-repetition frequency equal to twice the PRF of the first-wavelength optical pulses. The second optical delay loop is arranged to receive replica-bursts from the first optical delay loop and arranged to divide each of the replica-bursts into a plurality of replicas thereof with the replicas of each replica-burst being temporally spaced apart by τ/4±aΔτ. This provides that the second optical delay loop delivers sequences of burst-replicas at a sequence-repetition frequency equal to four times the PRF of the first-wavelength optical pulses. The first and second optical delay loops can be arranged such that the sequences of burst-replicas have about equal energy. 

   
     BRIEF DESCRIPTION OF THE DRAWINGS 
     The accompanying drawings, which are incorporated in and constitute a part of the specification, schematically illustrate a preferred embodiment of the present invention, and together with the general description given above and the detailed description of the preferred embodiment given below, serve to explain principles of the present invention. 
       FIG. 1  schematically illustrates one preferred embodiment of laser apparatus in accordance with the present invention, including a mode-locked resonator having a resonator length and delivering optical pulses having a fundamental wavelength at a pulse-repetition period, a harmonic generator for converting the fundamental-wavelength pulses delivered by the laser-resonator to harmonic-wavelength pulses and a pulse-stretcher including an optical delay loop having a round-trip length fractionally different from twice the resonator length. 
       FIG. 2  schematically illustrates one example of an optical delay loop of the apparatus of  FIG. 1 , including three concave mirrors and a plane beamsplitter arranged and aligned to divide the harmonic-wavelength pulses into a plurality of temporally spaced-apart replicas following a common path in the delay loop and to recombine replicas of different ones of the harmonic-wavelength pulses along a common path in bursts thereof having a burst-duration much less than the pulse-repetition period of the mode-locked laser. 
       FIG. 3  schematically illustrates another preferred embodiment of laser apparatus in accordance with the present invention, similar to the apparatus of  FIG. 1 , but wherein the delay loop delivers the pulse-replicas along different paths and the apparatus further includes beam-combining optics for recombining the pulse-replicas on a common path or on a target. 
       FIG. 4  schematically illustrates one example of an optical delay loop of the apparatus of  FIG. 3 , similar to the delay loop of  FIG. 2 , but wherein the three concave mirrors and the plane beamsplitter are misaligned such that the temporally spaced apart replicas follow different paths in the delay loop and exit the delay loop along different paths. 
       FIG. 4A  schematically illustrates an example of the plane beamsplitter in the delay loop of  FIG. 4 , the beamsplitter having zones of different reflectivity thereon corresponding to the different replica-paths in the delay loop. 
       FIG. 5  is a timing diagram schematically illustrating division of harmonic-wavelength pulses into replicas thereof and recombination of replicas of different pulses into bursts thereof in a delay loop such as the delay loop of  FIG. 2 . 
       FIG. 6  is a timing diagram schematically illustrating division of harmonic-wavelength pulses into replicas thereof and recombination of replicas of different pulses into bursts thereof in a delay loop such as the delay loop of  FIG. 4 . 
       FIG. 7  schematically illustrates yet another preferred embodiment of laser apparatus in accordance with the present invention, similar to the apparatus of  FIG. 1  but wherein bursts of pulses from the pulse-stretcher are delivered to a second pulse-stretcher having a round-trip length having a fractionally different length from twice the resonator length, the second pulse-stretcher arranged to divide first bursts of replica pulses from the first pulse-stretcher into a plurality of temporally spaced-apart replicas of the pulse-bursts following a common path in the delay loop and to recombine different ones of the first pulse-burst-replicas along a common path in second bursts thereof having a burst-duration much less than the pulse-repetition period of the mode-locked laser, but having more replicas per burst, and a burst-duration longer than that of the first pulse-bursts. 
       FIG. 7A  schematically illustrates a variation of the apparatus of  FIG. 7  wherein the second pulse-stretcher alternates the polarization of radiation circulating therein on successive round trips therein. 
       FIG. 7B  schematically illustrates a delay loop suitable for the second pulse-stretcher of the apparatus of  FIG. 7A , similar to the delay loop of  FIG. 2 , but including a half-wave plate arranged such that sequential burst-replicas generated in the delay loop are plane-polarized perpendicular to each other. 
       FIG. 8  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of the second pulse-stretcher including a delay loop similar to the delay loop of  FIG. 2 , and recombination of replicas of different pulse-replica-bursts into longer bursts, with the first and second delay loops each have a round-trip length fractionally greater than twice the resonator-length of the mode-locked laser. 
       FIG. 8A  is a graph schematically illustrating computed relative intensity as a function of time in a burst of replicas of hypothetical sech-squared pulses from the second pulse-stretcher of the apparatus of  FIG. 8  wherein the first and second pulse-stretchers each have a delay loop similar to the delay loop of  FIG. 2 , and wherein the first pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus seven-times the pulse-duration of the harmonic-wavelength pulses, and the second pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus twelve-times the pulse-duration of the harmonic-wavelength pulses. 
       FIG. 8B  is a graph schematically illustrating computed relative intensity as a function of time in a burst of replicas of hypothetical sech-squared pulses from the second pulse-stretcher of the apparatus of  FIG. 8  wherein the first and second pulse-stretchers each have a delay loop similar to the delay loop of  FIG. 2 , and wherein the first pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus three-times the pulse-duration of the harmonic-wavelength pulses, and the second pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus sixteen-times the pulse-duration of the harmonic-wavelength pulses. 
       FIG. 9  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of the second pulse-stretcher of  FIG. 7  including a delay loop similar to the delay loop of  FIG. 2  and recombination of replicas of different pulse-replica-bursts into longer bursts, with the first and second delay loops having a round-trip lengths respectively fractionally greater and fractionally less than twice the resonator-length of the mode-locked laser. 
       FIG. 9A  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of the second pulse-stretcher of  FIG. 7A  including a delay loop similar to the delay loop of  FIG. 7B  and recombination of horizontally and vertically polarized replicas of different pulse-replica-bursts into longer bursts, with the first and second delay loops each having a round-trip length fractionally greater than twice the resonator-length of the mode-locked laser. 
       FIGS. 9B-D  are graphs schematically illustrating computed relative intensity as a function of time in a burst of replicas of hypothetical sech-squared pulses from the second pulse-stretcher of the apparatus of  FIG. 7A  wherein the first pulse-stretcher has a delay loop similar to the delay loop of  FIG. 2  and the second pulse-stretcher has a delay loop similar to the delay loop of  FIG. 7B , and wherein the first pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus six-times the pulse-duration of the harmonic-wavelength pulses, and the second pulse-stretcher has a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses minus five-times the pulse-duration of the harmonic-wavelength pulses. 
       FIG. 10  schematically illustrates yet another preferred embodiment of laser apparatus in accordance with the present invention similar to the apparatus of  FIG. 1  but wherein the pulse-stretcher includes an optical delay loop having a round-trip delay time fractionally different from one-half of the pulse-repetition period of the mode-locked resonator. 
       FIG. 10A  schematically illustrates still another preferred embodiment of laser apparatus in accordance with the present invention, similar to the apparatus of  FIG. 7  but wherein the first pulse-stretcher includes an optical delay loop having a round-trip delay time fractionally different from one-half of the pulse-repetition period of the mode-locked resonator, and the second pulse-stretcher includes an optical delay loop having a round-trip delay time fractionally different from one-quarter of the pulse-repetition period of the mode-locked resonator. 
       FIG. 11  is a timing diagram schematically illustrating generation of pulse-bursts in an example of the apparatus of  FIG. 10 . 
       FIG. 11A  is a graph schematically depicting detail of relative power as a function of time in four pulse-bursts generated in an example of the pulse-stretcher of  FIG. 10 . 
       FIG. 11B  is a timing diagram schematically illustrating generation of pulse sequences in an example of the apparatus of  FIG. 10A . 
       FIG. 11C  is a graph schematically depicting detail of relative power as a function of time in five pulse-sequences generated in an example of the second pulse-stretcher of  FIG. 10A  from equally-energy input bursts from the first pulse-stretcher of  FIG. 10A . 
   

   DETAILED DESCRIPTION OF THE INVENTION 
   Referring now to the drawings, wherein like components are designated by like reference numerals,  FIG. 1  schematically illustrates one preferred embodiment  10  of laser apparatus in accordance with the present invention. Apparatus  10  includes a mode-locked resonator  12  having a resonator (cavity) length L. It is emphasized that the length L, as defined here, is the round-trip length of the resonator, i.e., in a linear resonator having first and second end-mirrors, L is twice the distance from the first end-mirror to the second end-mirror. Length L is an optical round-trip length of the resonator and includes the effect of refractive index of a gain-medium (also not shown) and any other refractive optical elements therein. 
   Mode-locked resonator  12  delivers optical pulses having a fundamental wavelength at a pulse-repetition period τ. The pulse-repetition period is dependent on the optical length of the resonator and is equal to the round-trip time τ for fundamental radiation in the resonator, i.e., the round-trip length L divided by the speed of light. The pulse repetition frequency (PRF) of pulses delivered is, of course, 1/τ. The present invention is particularly useful when the PRF of the fundamental wavelength pulses is greater than about 10 MHz and the pulse-duration of the fundamental wavelength optical pulses is less than about 100 picoseconds. 
   In one example of the above-discussed Paladin™ laser, the PRF of the resonator is about 80 MHz, i.e., τ is about 12.5 nanoseconds (ns). The pulse-duration (FWHM) is about 15 picoseconds, i.e., τ is about 830 times the pulse-duration. As noted above, this laser generates pulses of third-harmonic (3H) radiation having a wavelength of about 355 nm from fundamental-wavelength pulses having a wavelength of about 1064 nm. For convenience of description, reference is made to this laser further in this description, but this should not be construed as limiting the invention to the particular structure or parameters of this mode-locked laser. 
   In apparatus  10 , pulses of fundamental-wavelength radiation from resonator  12  are delivered to a harmonic generator  14  along path A. The harmonic generator converts the fundamental-wavelength pulses delivered by the laser-resonator to harmonic-wavelength pulses. Harmonic generator  14  may include only one optically nonlinear crystal arranged to generate pulses of second-harmonic radiation, or two or more optically nonlinear crystals arranged to generate pulses of third or higher harmonic-wavelength radiation as is known in the art. 
   Harmonic-radiation pulses from harmonic generator  10  are delivered along path B to a pulse stretching delay loop (pulse-stretcher)  16  in accordance with the present invention. 
   An inventive aspect of this pulse-stretcher is that the delay loop thereof has as round-trip of L±ΔL, where ΔL is a relatively small fraction, for example, less than about one-hundredth of round-trip length L. In other words, the delay loop of stretcher  16  preferably has a round-trip delay time of τ±Δτ, where Δτ is on the order of a few pulse-durations, i.e., the round-trip delay time is fractionally greater than or less than a pulse-repetition period. A pulse-repetition period of 12.5 ns corresponds to a delay loop round-trip length of about 3.75 meters and a resonator length of about 1.875 meters. Prior-art pulse-stretchers of the type described in above referenced U.S. Pat. No. 7,035,012 have a delay time per round-trip that is only between one-half and a few pulse-durations. 
     FIG. 2  schematically illustrates one example of an optical delay loop  16 A suitable for use in the apparatus of  FIG. 1 . Delay loop  16 A includes a beamsplitter  18  that is partially reflective and partially transmissive for the wavelength of harmonic-wavelength pulses generated by the harmonic generator of apparatus  10 . Each of the harmonic-wavelength pulses is incident on beamsplitter  18 , which reflects a portion (the first or prompt replica) of the pulse along path C and transmits the remainder of the pulse into the delay loop. In the delay loop, the remainder of the pulse is incident sequentially on concave mirrors  20 ,  22 , and  24 , which are preferably configured to image the remainder of the pulse 1:1, and preferably in the same orientation, back onto the beamsplitter at the original point of incidence. A portion of the remainder of the pulse is transmitted through the beamsplitter along path C as a second replica of the pulse and the remainder of that remainder goes around the delay loop again to provide third fourth, fifth etc. replicas until the pulse-replicas become vanishingly small and there is essentially nothing remaining of the pulse in the delay loop. 
   Relay imaging in delay loop  16 A is at unit magnification (1:1) when mirrors  20  and  24  have the same focal length. Mirrors  20 ,  22 ,  24 , and beamsplitter  18  are preferably separated by a distance approximately equal to f 1 +2f 2 . Where f 1  is the focal length of mirrors  20  and  24 , and f 2  is the focal length of mirror  22 . This ensures that a source in the plane of beamsplitter  18  is relay imaged onto the same plane after a complete roundtrip in delay loop  16 A. Preferably f 1  is about equal to 2f 2 . This provides that the size of a circulating pulse (pulse-beam) is the same on all three mirrors and beamsplitter  18 , and that focal points (waists) of the beam are located about mid-way between mirrors  20  and  22 , and between mirrors  24  and  22 . 
   The first replica of the pulse will have a relative (to the original pulse) peak-intensity (relative peak-power) R, where R is the reflectivity of the beamsplitter at the harmonic wavelength. The remaining (transmitted) replicas will have a relative power P(n) that can be approximated by an equation:
 
 P ( n )=(1 −A ) n−1 (1 −R ) 2   R   n−2   (1)
 
where A is the round-trip loss from scatter, absorption and the like, and n is the replica-number 2, 3, 4, and so forth. It can be determined from equation (1) that, in this loop configuration, the lowest peak relative power in a set (burst) of replicas of any one pulse will be obtained when the first and second replicas thereof have equal peak-power. The value of R required to establish this condition can be approximated by an equation:
 
                 R   =         2   ⁢   A     -   3   +       5   -     4   ⁢           ⁢   A             2   ⁢     (     A   -   1     )                 (   2   )               
By way of example, for a round-trip loss A of 0.02 R will be about 37.85%.
 
   It can also be determined that whatever the peak-power of the first and second replicas, the third replica will have a peak-power less than either the first and second replicas. It can further be determined that the fourth and higher replicas will have a lower peak-power than the forgoing replica; and more than 99% of the maximum pulse energy obtainable, i.e., after round-trip losses, is contained in the first six replicas of any pulse. All pulse-replicas of any one pulse that are delivered by a delay loop are temporally spaced apart by τ±Δτ. 
     FIG. 3  schematically illustrates another preferred embodiment  11  of laser apparatus in accordance with the present invention similar to apparatus  10  of  FIG. 1  but wherein the delay loop  16  of apparatus  10  is replaced by a delay loop  17  that delivers a predetermined number (here four) of replicas of each pulse, with each replica delivered along a different path. The four paths are designated P 1 , P 2 , P 3 , and P 4 . Beam-combining optics  26  combine the replicas along a common path C as illustrated. Alternatively, beam-combining optics can be provided that focus the different replica paths at a common point on a target to which the replicas are being delivered. Various forms of beam-combining optics are known in the art to which the present invention pertains. As a detailed description of any such beam-combining optics is not necessary for understanding principles of the present invention, no such detailed description is presented herein. 
     FIG. 4  depicts one example  17 A of delay-loop  17 . Delay loop  17 A is similar to delay loop  16 A of  FIG. 2  with an exception that the beamsplitter and mirrors of the loop are misaligned from the alignment of  FIG. 2  such that, after a first round trip in the loop, the remainder of the pulse is incident on the beamsplitter at a point thereon spaced apart from the point of entry. After a second and third round trips in the loop the remainder of the remainder of the pulse, and the remainder of the remainder of the remainder of the pulse, are incident on the beamsplitter at other spaced-apart points. 
   Another exception is that beamsplitter  18  of loop  16 A is replaced in loop  17 A by a beamsplitter  18 S, the reflectivity (and transmission) of which is graded or stepped over the beamsplitter such that reflectivity thereof is dependent on the location thereon of incident radiation.  FIG. 4A  schematically illustrates one example of reflective zones R 1 , R 2 , R 3 , and R 4  on a beamsplitter  18 S corresponding to the location thereon of paths P 1 , P 2 , P 3 , and P 4 , respectively. The paths are spaced apart and about parallel to each other. The reflectivity R 4  at the point of incidence on beamsplitter  18 S after the third round trip is made as close to zero as possible. Alternatively, the beamsplitter can be configured such that after the third round trip the remaining pulse energy bypasses the beamsplitter altogether. 
   An advantage of this type of loop is that the reflectivity-grading or reflectivity-stepping of the beamsplitter can be selected such that each replica of any one pulse has about the same peak-power. A disadvantage is that beam quality on target will usually be less than optimum due to the separation of the replica paths. Delay loop  17 A is only one example of a loop that can provide a predetermined number of replicas along a corresponding number of separate paths. Others are described in above-referenced U.S. Pat. No. 7,035,012, the complete disclosure of which is hereby incorporated by reference. Any of these loops can be operated in an aligned form as an “infinite” loop, such as loop  16 A, with all replicas leaving the loop on a common path. 
     FIG. 5  is a timing diagram schematically illustrating division of harmonic-wavelength pulses into replicas thereof and recombination of replicas of different pulses into bursts thereof in a delay loop such as the delay loop of  FIG. 2 . The vertical axis in each line of the timing diagram is relative peak-power. The timing diagram is meant to represent operation of apparatus  10  immediately after the resonator begins to deliver pulses. The temporal development of replicas of the first through sixth pulses is depicted. Replicas D 1 , D 2 , D 3 , D 4 , and D 5  are depicted for each of the six pulses. Replicas D 1  and D 2  are assumed to have the same peak-power. In a delay loop  16 A having a loss of 2% per round trip, this will occur when the reflectivity of beamsplitter  18  is about 37.9% and there is no second-surface reflection. Replicas D 3 , D 4  and D 5  have progressively diminishing peak-power, and it is assumed that higher numbered replicas have a sufficiently low peak-power as to be negligible. By way of example for an input pulse of unit peak-power D 1 , D 2 , D 3 , D 4 , and D 5  will have relative peak values of about 0.379, 0.379, 0.140, 0.052, 0.019. The next replica would have a peak-power less than 1% of the input pulse. It is assumed that the round-trip delay in the resonator is τ±Δτ. Successive replicas of any one pulse are temporally spaced apart by this round-trip delay time. The first replica of any one pulse is temporally spaced apart from the first replica of an immediately previous pulse by the pulse-repetition period τ. 
   It can be seen that there is a transient period of about 4 round-trip times until a burst B 1  of 5 replicas is output. The burst comprises, in time sequence, the first replica of the fifth pulse, the second replica of the fourth pulse, the third replica of the third pulse, the fourth replica of the second pulse, and the fifth replica of the first pulse, with the replicas spaced apart by Δτ. Similar bursts will follow at intervals of τ, i.e., the pulse-repetition period of pulses from the mode-locked resonator, with each burst comprising, in general, the sum of replicas P n (D 1 ), P n−1 (D 2 ), P n−2 (D 3 ), P n−3 (D 4 ), P n−4 (D 5 ) where Pn is the n th  pulse, Pn−1 is the (n−1) th  pulse and so forth. 
   It should be noted here that pulses from a mode-locked resonator are typically highly coherent, and replicas thereof will also be highly coherent. Accordingly, it is advisable to select a delay loop length such that Δτ is at least about one pulse-duration, and preferably at least two or three pulse-durations, to avoid optical interference between the pulse-replicas. With a replica separation of three pulse-durations, the effective burst-duration will be only about twelve pulse-durations, i.e., about 1.5% of a pulse-repetition period for 15-picosecond pulses at a PRF of 80 MHz. The term “effective”, as used here, implies that the sixth and higher replicas of individual pulses have negligible contribution. The bursts of replicas will have an effect on a target of single, stretched pulses delivered at the PRF of the laser-resonator. 
   It should also be noted that if the length of the delay loop is selected such that the round-trip time therein is τ-Δτ, pulse-replicas in a burst will be in a temporal sequence that is the reverse of the sequence discussed above, i.e., P n−4 (D 5 ), P n−3 (D 4 ), P n−2 (D 3 ), P n−1 (D 2 ), and P n (D 1 ). This is not possible in a prior-art closed-loop pulse-stretcher wherein the round-trip time is on the order of a pulse-duration. Such a sequence can be used to “tailor” the energy-deposition temporal profile in pulse-bursts when two stretchers are “cascaded”. Examples of this are presented further hereinbelow. 
     FIG. 6  is a timing diagram schematically illustrating division of harmonic-wavelength pulses into replicas thereof and recombination of replicas of different pulses into bursts thereof in a delay loop such as the delay loop of  FIG. 4 . In this example graded beamsplitter  18 S of delay loop  17 A (see  FIG. 4 ) has been arranged such that only four replicas per pulse are created, all having the same peak-power. In this case, the temporal sequence of replicas in a burst is un-important. Whatever the temporal sequence, the energy deposition profile in a burst of replicas can be tailored by appropriate selection of stepped or graded reflectivity in the beamsplitter of the delay loop. 
   It is emphasized here that although the round-trip length of a delay loop in accordance with the present invention is only longer or shorter than that length required to provide a delay time equal to τ by a relatively small fraction, the fraction, in length units, is a few millimeters more or less than the round-trip length. This is very much greater than common manufacturing tolerances anticipated in constructing the loop or in variations in the loop length that might occur through environmental effects such as temperature variations or the like. In other words, the fractional difference is highly unlikely to occur by accident, and, in a properly constructed loop the length of the loop can be stabilized such that the fractional delay time Δτ does not vary significantly in normal use. 
     FIG. 7  schematically illustrates yet another preferred embodiment  15  of laser apparatus in accordance with the present invention similar to the apparatus of  FIG. 1 , but wherein bursts of pulses from pulse-stretcher  16  are delivered along common path C to a second pulse-stretcher  19  having a round-trip length fractionally different from the round-trip resonator length and different from the round-trip length in pulse-stretcher  16 . Pulse-stretcher  19  is arranged to divide bursts of replica pulses from pulse-stretcher into a plurality of temporally spaced-apart replicas of the pulse-bursts following a common path in the delay loop and to recombine different ones of the first pulse-burst-replicas along a common path E. Pulse-stretcher  19  outputs burst of replicas with each of the bursts having more replicas per burst than the input bursts and a longer burst-duration than the input bursts. 
     FIG. 8  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of pulse-stretcher  19  including a delay loop similar to the delay loop of  FIG. 2 . In this example, the beamsplitter reflectivity of both pulse-stretchers is assumed to be that which will provide that the first two replicas of a pulse (in the case of first pulse-stretcher  16 ) or a burst thereof (in the case of first pulse-stretcher  19 ) have equal peak-power. Accordingly, the first two replica pulses in portions  1  and  2  of a first burst of pulse-replicas have a relative peak-power of about 0.143 with the first two replicas in subsequent portions scaling accordingly as depicted in the first line of  FIG. 8 . 
   The burst-portions are spaced apart by a time period τ+aΔτ, where a is selected (cooperative with the temporal spacing Δτ of replicas in a burst) according to a desired degree of temporal overlap of burst-portions at the output of pulse-stretcher  19 , while still maintaining a preferred temporal spacing of at least two pulse-durations between any two replicas in the overlapping burst-portions. Here, after 4 pulse-bursts have been delivered into pulse-stretcher  19  from pulse-stretcher  16  (the first 4 lines of the timing diagram of  FIG. 8 ) the output of pulse-stretcher  19  (the bottom line of the timing diagram of  FIG. 8 ) will comprise, portion  1  of burst  4 , portion  2  of burst three, portion  3  of burst two, and portion  4  of burst  1 . The burst-portions are combined and temporally overlapped to form, in effect, a single burst of pulse-replicas. Similar combined burst-portions will be output from pulse-stretcher  19  at time intervals of τ, i.e., at the PRF of the mode-locked laser. 
   The relative temporal position of replicas in a combined burst can be determined by tabling values of an expression:
 
 x =( m −1) a +( n −1) b   (3)
 
for integer values 1 through m and 1 through n, where a and b are specified in pulse-durations, a is the separation of replicas in a burst and b is the separation of burst-portions in a combination thereof, n is the number of significant replicas in a burst and m is the number of significant burst-portions in a combination. Values of x in the table can be searched to make sure that there are no replicas too closely spaced according to whatever criterion is selected.
 
     FIG. 8A  is a graph schematically illustrating computed relative intensity as a function of time in a burst of replicas at the output of pulse-stretcher  19  with the following assumptions. The replicas are assumed to be “sech squared” pulses. The first pulse-stretcher is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus seven-times the pulse-duration of the harmonic-wavelength pulses, and the second pulse-stretcher is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus twelve-times the pulse-duration of the harmonic-wavelength pulses. The beamsplitter reflectivity in each pulse-stretcher is assumed to be 37.85% with round-trip losses of 2% in each pulse-stretcher. The sixth and higher replicas in a burst are neglected and the fifth and higher burst-portions are neglected. A pulse-duration is about 1.7 on the arbitrary time scale. No two pulse-replicas are spaced apart by less than about two pulse-durations. 
     FIG. 8B  is a graph schematically illustrating computed relative intensity as a function of time in a burst of replicas at the output of pulse-stretcher  19 . Here assumptions are the same as for the graph of  FIG. 8  with an exception that the first pulse-stretcher is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus three-times the pulse-duration of the harmonic-wavelength pulses, and the second pulse-stretcher is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus sixteen-times the pulse-duration of the harmonic-wavelength pulses. 
     FIG. 9  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of pulse-stretcher  19  of  FIG. 7  including a delay loop similar to the delay loop of  FIG. 2 . Replicas of different pulse-replica-bursts are combined into longer bursts as described above with reference to  FIG. 8 . In the timing diagram of  FIG. 9 , however, the delay loops of pulse-stretchers  16  and  19  are assumed to have round-trip lengths respectively fractionally greater and fractionally less than the round-trip resonator-length L of the mode-locked laser. A result of this is that, in combined burst-portions at the output of pulse-stretcher  19 , pulse-replicas having the highest peak-power are located in the center of the combination of bursts with replicas having lower power ahead of and behind these highest-peak-power replicas, as indicated in the bottom line of the timing diagram of  FIG. 9 . 
   In the discussion presented above, the importance of avoiding temporal overlap of pulse-replicas is discussed in the context of avoiding interference. In cases where polarization of radiation delivered to a target is not important, it is possible to cause some replicas in a burst thereof to be plane-polarized in a first orientation, and others to be plane-polarized in a second orientation perpendicular to the first orientation. If a pulse-replica plane-polarized in the first orientation temporally overlaps a pulse-replica plane-polarized in the second orientation the replicas will not interfere. 
   One means of effecting alternate polarization of replicas is depicted in  FIG. 7A . Here a second pulse-stretcher  19 A is configured such that the polarization of radiation circulating therein is rotated by 90 degrees on successive round-trips of the delay loop.  FIG. 7B  schematically illustrates one example  19 B of a delay loop for effecting this polarization rotation. Delay loop  19 A is similar to the delay loop of  FIG. 2  with an exception that a half-wave (at the wavelength of the harmonic-wavelength pulses) plate  30  is included in the path of radiation in the loop. If radiation circulating in the resonator is vertically polarized on a nth round trip as indicated in  FIG. 7B  by arrow Pn, the radiation will be horizontally polarized on an (n+1)th round trip as indicated by arrowhead Pn +1 . 
   In this arrangement, it is recommended that the delay loop be configured such that the angle of incidence on beamsplitter  18  be as near normal as is practical. This will minimize the reflectivity difference on the beamsplitter for the different polarization-orientations. 
   However, at an angle sufficiently different from normal, for example about 45°, a beamsplitter can be designed that has a predetermined polarization-dependence of reflectivity, with this dependence used as an additional variable for tailoring the relative intensity of replicas output by the delay loop. 
   By way of example, if the beamsplitter in a lossless loop has a reflectivity for the input polarization-orientation of about 29.289% and a reflectivity of about 58.578% for a polarization-orientation perpendicular to the input polarization-orientation, then the first three replicas will have a relative intensity of 0.29289 and the fourth replica and fifth replicas will have a relative intensity of only 0.0502. The sixth replicas will have a relative intensity of about 0.008. There will be about 88% of the input pulse energy in the first three replicas. The peak-intensity in a burst of replicas will be about 25% less than would be the case for an optimized loop without polarization dependence. 
   For real (lossy) conditions the two reflectivity values (R P  and R S ) can be approximated by equations: 
                   R   P     =       1   +     1   T     +     2   ⁢           ⁢   T     -         1   +     2   ⁢           ⁢   T     +     5   ⁢           ⁢     T   2           T         2   ⁢     (     1   +   T     )                 (   4   )               
and
 
                   R   S     =       1   +     3   ⁢           ⁢   T     -       1   +     2   ⁢           ⁢   T     +     5   ⁢           ⁢     T   2               2   ⁢           ⁢   T               (   5   )               
where T is 1.0 minus the round trip loss, and R P  has the lower of the two values.
 
     FIG. 9A  is a timing diagram schematically illustrating division of bursts of harmonic-wavelength pulses into replicas thereof by an example of the second pulse-stretcher including a delay loop similar to the delay loop of  FIG. 7B  and recombination of horizontally and vertically polarized replicas of different pulse-replica-bursts into longer bursts. In  FIG. 9A , vertically polarized pulse-replicas are designated by bold lines and horizontally-polarized pulse-replicas are designated by fine lines. Odd-numbered portions of pulse-bursts created by the second pulse-stretcher from a burst of pulses received from the first stretcher are assumed to be vertically polarized. Even-numbered burst-portions are assumed to be horizontally polarized. In a burst of replicas at the output of the second-pulse-stretcher the most closely temporally spaced replicas are plane-polarized perpendicular to each other. Those skilled in the art will recognize without further detailed description or illustration that a half-wave plate could be incorporated in the first pulse-stretcher such that odd and even numbered pulse-replicas were plane-polarized perpendicular to each other. 
     FIGS. 9B-D  are graphs schematically illustrating computed relative intensity as a function of time in a burst of replicas of hypothetical sech-squared pulses from the second pulse-stretcher of the apparatus of  FIG. 7A  wherein the first pulse-stretcher has a delay loop similar to the delay loop of  FIG. 2  and the second pulse-stretcher has a delay loop similar to the delay loop of  FIG. 7B . The first pulse-stretcher is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses plus six-times the pulse-duration of the harmonic-wavelength pulses. The second pulse-stretcher (the polarization alternating stretcher) is assumed to have a round-trip time equal to a pulse-repetition period of the harmonic-wavelength pulses minus five-times the pulse-duration of the harmonic-wavelength pulses. Odd and even numbered burst-portions generated by delay loop  19 B are assumed to be respectively vertically and horizontally polarized. The beamsplitter in the polarization alternating stretcher is assumed to have the same reflectivity for each polarization state. Other assumptions are the same as those of the computation of  FIG. 8A . 
     FIGS. 9B and 9C  graphically depict respectively the sum of vertically-polarized pulse-replicas and the sum of horizontally polarized replicas (curves V and H respectively) at the output of the second pulse-stretcher. In each case, the temporally closest-spaced pulse-replicas are separated by at least about two pulse-durations and also have very different peak-power, such that the difference between any constructive and destructive interference will be negligible. 
     FIG. 9D  graphically depicts the sum of the horizontally and vertically polarized sums. Here, there are three central peak components formed by temporally overlapping vertical and horizontally polarized components. There will, accordingly, not be any interference in these peaks 
   It is evident from the above described examples that arranging two of the inventive pulse-stretchers “cascaded” in optical series, and using available variables such as positive and “negative” delay, different delay values, and overlapping pulse-replicas perpendicular to each other affords significant flexibility in tailoring the temporal energy deposition profile of a replica pulse-burst delivered by the second pulse-stretcher. Additional flexibility is possible by varying the reflectivity of the beamsplitters in the two pulse-stretchers. 
   In above-described embodiments of the invention, each pulse-stretcher has a round-trip delay that is fractionally different from the round-trip time of radiation in the mode-locked resonator, i.e., fractionally different from a pulse-repetition period τ of the mode-locked resonator. The fractional difference referred to here is less than a few percent of τ. Variables discussed above can also be used to advantage in embodiments of the present invention wherein the inventive pulse-stretching delay loops have a round-trip delay-time that is fractionally different from a submultiple of the resonator round-trip time τ(τ/N±Δτ, where N is an integer equal to or greater than 2) of the resonator. This is achieved by making the length of a delay loop about equal to L/N±ΔL, where L as noted above, is the round-trip optical length of the resonator. In such embodiments the PRF of stretched harmonic-wavelength pulses is N times the PRF of the fundamental-wavelength pulses. 
     FIG. 10  schematically illustrates yet another preferred embodiment  21  of laser apparatus in accordance with the present invention that provides stretched harmonic-wavelength pulses at a PRF higher than that of the fundamental wavelength pulses. Apparatus  21  is similar to apparatus  10  of  FIG. 1  with an exception that pulse-stretcher  16  of apparatus  10  is replaced in apparatus  21  by a pulse-stretcher  23  that includes a delay loop having a round-trip delay time of τ/2±Δτ, i.e., fractionally different from one-half of the round-trip time τ of mode-locked resonator  12 . The round-trip time of mode-locked resonator  12  is, of course, equal to the pulse-repetition period of the resonator. 
     FIG. 11  is a timing diagram schematically illustrating generation of pulse-bursts in an example of the apparatus of  FIG. 10 . Pulse-stretcher  23  divides each input pulse into replicas D 1 , D 2 , D 3 , D 4 , and so forth as discussed above. Here fifth and six replicas have too low a peak-power to be depicted and, accordingly, are neglected. The replicas of any pulse each have a different peak-power. In  FIG. 11 , the second replica of each pulse has a higher peak-power than the first replica for reasons that are discussed further hereinbelow. The third replica has a lower peak-power than the first replica, and the fourth replica has a lower peak-power than the third replica, as discussed above. The delay loop is assumed to have a round-trip delay time of τ/2+Δτ, and the replicas of each pulse are temporally spaced by this time-interval. The first replicas of successive pulses are temporally spaced by the pulse-repetition period τ. The steady state output of pulse-stretcher  23 , depicted on the bottom line of the timing diagram of  FIG. 11  will comprise bursts of pulse-replicas B 1 , B 2 , B 3 , B 4 , B 5 , and so forth, at a burst-repetition frequency that is twice the PRF of mode-locked resonator  12 . 
   The bursts of pulse-replicas can be considered as “stretched” pulses repeated at twice the PRF of mode-locked resonator  12 . The burst-repetition frequency can be considered as a stretched-pulse-repetition frequency. 
   In  FIG. 11 , as the fifth and higher replicas of each pulse are neglected, burst B 1  comprises the first replica of the third pulse and the third replica of the second pulse. Burst B 2  comprises the second replica of the third pulse and the fourth replica of the second pulse. Burst B 3  comprises the first replica of the fourth pulse and the third replica of the third pulse, and burst B 4  comprises the second replica of the third pulse and the fourth replica of the second pulse. Burst B 3  will actually also comprise the fifth replica (not shown) of the second pulse. Burst B 4  will actually also comprise the sixth replica (not shown) of the second pulse. Generally, in the steady state, an n th  burst of replicas will comprise only even numbered pulse-replicas and an (n+1) th  burst of replicas will comprise only odd numbered replicas, although any replica higher than the sixth will have vanishingly small peak-power, and can be neglected in most cases. 
   Now, in certain applications, it may be desirable that each burst of pulse-replicas (stretched pulse) have the same energy. This can be achieved by selecting a suitable value for beamsplitter  18  in the delay loop. Recognizing that equation (1) discussed above for computing the intensity of a particular transmitted replica defines a geometric progression having a common ration R(1−A) and a scale factor (1−A) (1−R) 2 , and defining T=(1−A) the total intensity I ODD  of odd-numbered replicas will be given by an equation: 
                   I   ODD     =     R   +           (     1   -   R     )     2     ⁢     RT   2         1   -       R   2     ⁢     T   2                     (   6   )               
and the total intensity I EVEN  of even-numbered replicas will be given by an equation:
 
                   I   EVEN     =           (     1   -   R     )     2     ⁢   T       1   -       R   2     ⁢     T   2                   (   7   )               
from which it can be determined that I ODD  and I EVEN  will be equal when:
 
   
     
       
         
           
             
               
                 R 
                 = 
                 
                   T 
                   
                     1 
                     + 
                     
                       2 
                       ⁢ 
                       
                           
                       
                       ⁢ 
                       T 
                     
                   
                 
               
             
             
               
                 ( 
                 8 
                 ) 
               
             
           
         
       
     
   
   R will be ⅓ (33.333 . . . %) when the round-trip loss is zero (T=1). For a round-trip loss of 2% (T=0.98), R is about 33.108%. By way of example, this provides that the first, second, third, fourth, fifth, and sixth replicas of a pulse have relative peak-power (or peak-intensity) of, about, 0.331, 0.439, 0.142, 0.046, 0.015, and 0.005. 
   Similarly it can be determined that total loss L TOTAL  is given by an equation: 
                   L   TOTAL     =         (     1   -   R     )     ⁢     (     1   -   T     )         1   -   RT               (   9   )               
and that the intensity I in each of the equal-energy bursts is given by an equation:
 
                 I   =     R     1   -   RT               (   10   )               
where in each case R has been determined from equation (8). When T=1 (R=333.3333%) each of the equal energy bursts produced from an input pulse will have 50% of the energy of the input pulse.
 
   In practice it is difficult to obtain, at least from commercial suppliers, beamsplitters having a reflectivity with one or two tenths of a percent of a specified value between about 30% and 40%. In cases where equal burst-energy is of critical importance, it may be found useful to configure beamsplitter  18  such that it has a selectively variable reflectivity. This can be done, for example, by providing a coating having a continuously graded reflectivity (from a value high than a desired value to a value lower than the desired value) over the surface of the beamsplitter, with either an angular or linear gradient, and correspondingly rotating or translating the beamsplitter in the input beam path until equal burst-energy is obtained. A method of producing graded reflectivity coatings is described in U.S. Pat. No. 5,993,904, assigned to the assignee of the present invention, and the complete disclosure of which is hereby incorporated by reference. 
     FIG. 11A  is graph schematically illustrating computed relative power as a function of time of a sequence of equal-energy bursts of pulse-replicas from pulse-stretcher  23  in which Δτ is adjusted to provide a spacing of four pulse-durations between replicas. The time axis is greatly foreshortened to allow detail of the pulse-replicas to be depicted. Of note, here, is that while there are two bursts per repetition-period, the bursts are not temporally, exactly equally spaced. The temporal spacing of the bursts alternates between τ/2+Δτ and τ/2−Δτ. As already noted, however, Δτ will usually be less than about 1% of τ. 
     FIG. 10A  schematically illustrates still another preferred embodiment  21 A of laser apparatus in accordance with the present invention similar to the apparatus of  FIG. 10  but wherein the output of pulse-stretcher  23  is directed along a path C 1  into a second pulse-stretcher  25  having a round-trip length L/4+aΔL corresponding to a round-trip delay-time τ/4+aΔτ. The action of pulse-stretcher  25  is depicted, in timing diagram form, in  FIG. 11B . 
   Each burst from pulse-stretcher  23  is divided into portions in pulse-stretcher  25 . In  FIG. 11B , odd-numbered burst-portions are designated O 1 , O 2 , O 3 , and O 4 , with higher numbered portions O 5 , O 6 , and so forth, not visible on the scale of the diagram. Even-numbered burst-portions are designated E 1 , E 2 , E 3 , and E 4 , again, with higher numbered portions E 5 , E 6 , and so forth, also not visible on the scale of the diagram. In the output channel C of pulse-stretcher  25 , the bottom line of  FIG. 1B , there is a repeated series of four sequences or bursts of pulse-replicas. Each series includes sequences S 1 , S 2 , S 3 , and S 4 . These are delivered in a time period τ, such that the sequence repetition rate is four-times the pulse repetition rate of the mode-locked resonator. In the steady state, in general terms, S 1  comprises the 1 st  portion of the (n+1) th  burst from pulse-stretcher  23 , the 3 rd  portion of the nth burst, the 5 th  portion of the (n−1) th  burst, and so forth. S 2  comprises the 2 nd  portion of the (n+1) th  burst, the 4 th  portion of the n th  burst, the 6 th  portion of the (n−1) th  burst, and so forth. S 3  comprises the 1 st  portion of the (n+2) th  burst, the 3 rd  portion of the (n+1) th  burst, the 5 th  portion of the n th  burst, and so forth. S 4  comprises the 2 nd  portion of the (n+2) th  burst, the 4 th  portion of the (n+1) th  burst, the 6 th  portion of the n th  burst, and so forth. 
     FIG. 11C  is a graph schematically illustrating detail of computed relative power as a function of time for five pulse-sequences in the timing diagram of  FIG. 11B . As in  FIG. 11A , the time-axis is greatly foreshortened to allow detail of the pulse-replicas to be depicted. It is assumed in this computation that pulse-replicas in the input bursts are spaced apart by Δτ equal to four pulse-durations and that the value aΔτ is sixteen pulse-durations. It is also assumed that the input to pulse-stretcher  25  is replica-bursts of equal energy as discussed above. It is further assumed that the round-trip loss in each of the pulse-stretchers is 0.02, and that the reflectivity of the beamsplitter in each of the pulse-stretchers is about 33.1%, i.e., that value which provides the equal-energy bursts from pulse-stretcher  23 . Those having sufficient patience to compute the energy in each of the four sequences S 1 -S 4  will find that each sequence has about the same energy, even though each comprises a different set of replicas from those comprised by any other. As in the case of pulse-stretcher  23 , the sequences are not temporally, exactly equally spaced, but can be described as being about equally spaced. 
   The present invention is described above in terms of particular embodiments. Certain embodiments are arranged to deliver bursts of harmonic-wavelength pulse-replicas with temporal separation of pulses in the burst being only a relatively small fraction of the temporal separation of the pulses bursts. Although the invention is described in terms of generating the harmonic-wavelength pulse-replicas by extra-cavity frequency-conversion of fundamental-wavelength optical pulses, principles of the invention are also applicable to generating bursts of pulse-replicas of harmonic-wavelength pulses from an intra-cavity frequency-converted laser-resonator and even to generating bursts of fundamental wavelength pulses or frequency-converted pulses of a non-harmonic wavelength such are generated in the resonator of an optical parametric oscillator. 
   Those skilled in the art may devise other embodiments of the present invention combining features from the above-described embodiments with out departing from the spirit and scope of the present invention. Accordingly it is emphasized that the present invention is not limited to the embodiments described and depicted herein. Rather, the invention is limited only by the claims appended hereto.