Abstract:
The present invention provides a medical liquid administration apparatus and administration method that are particularly apt for intravenous (IV) applications. More particularly, the administration apparatus and method may be employed in conjunction with the administration of liquid medication and one or more flush solutions from multi-dose sources, wherein fluid interconnections between at least one flush solution source and the administration apparatus may be established a single time at the outset of a given procedure. The administration apparatus may include a valve having a control member selectively positionable to provide any selected one of a plurality of closed flow paths through the valve, and a syringe interconnected to the control member for clockwise/counterclockwise co-rotation therewith (e.g. to establish the selected flow path). The valve may include a valve housing have a plurality of ports, wherein in one arrangement at least two of the ports have corresponding center axes lying in offset first and second planes. Correspondingly, the control member may include an internal passageway extending between a plurality of apertures, wherein at least two of the apertures have center axes lying in said offset first and second planes. By selectively rotating the control member, different fluid paths may be established between different ones of the valve housing ports, thereby facilitating closed-path passage of a liquid medication and one or more flush solutions therethrough. In particular, the flush solution(s) and liquid medication may be passed sequentially into the interconnected syringe for subsequent manual administration by medical personnel.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS  
       [0001]     This application is a divisional application of and claims priority to U.S. patent application Ser. No. 10/225,886, filed on Aug. 22, 2002, and entitled “ADMINISTRATION OF IV LIQUID MEDICATION AND IV FLUSH SOLUTIONS, APPARATUS AND METHOD FOR”, the disclosure of which is incorporated herein by reference in its entirety. 
     
    
     FIELD OF THE INVENTION  
       [0002]     The present invention relates to the field of medical liquid administration, and more particularly, to an administration apparatus and method for administering multiple medical liquids during one or repeated periods. The administration apparatus and method are particularly apt for use in successive intravascular (IV) administrations of liquid medication and one or multiple flush solutions over an extended time period, wherein the liquid medication and flush solution(s) may be alternately infused through a closed system requiring only a single vascular catheter fluid interconnection per sequence.  
       BACKGROUND OF THE INVENTION  
       [0003]     Numerous techniques are employed for the administration of “medical liquids” (e.g. liquid medication and flush solutions) to a patient. In particular, where repeated medication infusions are required, medical liquids are often administered via the use of a vascular access catheter that is fluidly interconnected or interconnectable to one or more medical liquid sources via an associated tubing line set. Typically, the catheter is inserted into the vein of a patient and left there for multiple intravenous (IV) infusions during an extended course of medication therapy. By way of example, the time period between IV drug infusions may be between about 4 to 24 hours, wherein the IV liquid medication source is typically replaced after each dose infusion. In the course of extended medication therapy a given tubing line set may be repeatedly employed, and a number of tubing line sets may be successively employed. For example, it is typical to replace a given tubing line set every two or three days.  
         [0004]     During extended therapy applications, a desirable practice is to disconnect the vascular catheter from a medical liquid source and tubing line set between infusions. In this regard, most patients receiving IV medication therapy are ambulatory to some degree and benefit from not being continuously connected.  
         [0005]     In conjunction with the repeated connection/disconnection of a vascular catheter and liquid medication source and tubing line set, it is usual practice to purge the vascular catheter with a flush solution (e.g. a saline solution) prior to and at the completion of a given liquid medication infusion. Pre-infusion flushing verifies that the vascular catheter is primed and clear of obstructions. Post infusion flushing not only flushes through any remaining liquid medication to achieve the desired therapeutic effect, but also reduces any chance that the vascular catheter may become blocked in-between infusions, e.g. by a blood clot that may otherwise form in the vascular catheter. In relation to infusion procedures, it is also common practice to verify the proper functioning of a vascular catheter via aspiration. This is typically done prior to pre-infusion flushing and after liquid medication infusion. The procedure entails using the flush solution syringe or liquid medication syringe to drain a small amount of a patient&#39;s blood through the vascular catheter, thereby permitting visual verification of proper vascular catheter functionability, then advancing the blood back through the vascular catheter using the syringe. By way of example, such procedure assures that the vascular catheter is not blocked by a blood clot and is otherwise properly inserted into a patient&#39;s vascular system.  
         [0006]     A number of approaches are currently utilized for the noted flushing procedures. Such techniques generally entail the usage of flush solutions packaged in large volume, multi-dose reservoirs (e.g. about 250 ml. or more) or pre-filled unit dose syringes (e.g. having volumes of 2, 3, 5 or 10 ml.).  
         [0007]     Where a unit dose syringe is utilized, medical personnel must generally remove the syringe from packaging, remove a cap from the syringe, remove any air in the syringe, swab a vascular catheter access port with an antibacterial material, interconnect the syringe to a vascular catheter access port, optionally aspirate the vascular catheter, advance the syringe plunger to infuse the flush solution (e.g. at a rate of about 5 to 10 ml. over about 15 to 30 seconds), remove the syringe from the vascular catheter access port and discard the used syringe with its wrapper. As may be appreciated, such steps may need to be repeated numerous times over the course of extended medication therapy, e.g. after each infusion and vascular catheter access port reconnection, thereby entailing significant medical personnel time and resulting in substantial medical waste. Further, while unit dose syringes provide good sensitivity for aspiration purposes they are not particularly pressure sensitive for flushing purposes.  
         [0008]     Where multi-dose flush solution reservoirs are employed, medical personnel typically utilize an empty unit dose syringe to draw the flush solution from the reservoir, then follow the same basic procedure noted above in an administering the flush solution. Again, such procedure may be followed a number of times during a medication therapy. Further, contamination concerns may arise when a unit dose syringe is filled from a multi-dose reservoir at the point of use. To address such concern, unit dose syringes are often filled from a multi-dose reservoir within a pharmacy department of a medical care facility utilizing a hepa-filter air hood. However, significant syringe handling is required. Moreover, labeling becomes a further need when a delay is expected between the filling of a unit dose syringe and the usage of the filled syringe.  
       SUMMARY OF THE INVENTION  
       [0009]     In view of the foregoing, a primary objective of the present invention is to reduce the number of steps and associated time required by medical personnel for the infusion of medical liquids in conjunction with IV procedures. A related objective is to facilitate the utilization of multi-dose flush solution sources in conjunction with IV liquid medication administration procedures occurring over an extended course of therapy.  
         [0010]     An additional objective of the present invention is to provide the noted medical liquid administration efficiencies in a manner that also enhances the maintenance of sterility.  
         [0011]     A further objective of the present invention is to facilitate the utilization of different types of flush solutions, including the use of two different flush solutions in conjunction with IV procedures for a given patient.  
         [0012]     Yet another objective of the present invention is to reduce medical waste associated with the IV administration of flush solutions.  
         [0013]     In addressing the noted objectives, the present inventors have recognized the desirability of providing an apparatus that fluidly interconnects fluid lines from multiple medical liquid sources to a single fluid line that is selectively interconnectable to a vascular catheter access port. More particularly, the inventors have recognized that desirability of providing an apparatus that allows a liquid medication source and multiple flush solutions to be administered in a closed system through a single fluid line that entails only a single interconnection to a vascular catheter access port.  
         [0014]     As such, one or more of the above objectives and additional advantages may be realized by an inventive medical liquid administration apparatus that comprises a valve having a control member selectively positionable to provide any selected one of a plurality of flow paths through the valve, and a syringe, fluidly interconnected to a syringe port of the valve, for receiving and dispensing medical liquid through the valve.  
         [0015]     In one aspect, the syringe may be fixedly interconnected to the control member for clockwise and counterclockwise co-rotation therewith. In this regard, the control member may be positionable so that in a first position a first flow path between a first inlet port of the valve and the syringe port is provided. The control member may be further positionable in a second position to provide a second flow path between the syringe and an outlet port of the valve. Such selective positioning facilitates the drawing of a first medical liquid (e.g. a first flush solution) into the syringe through the first inlet port when the control member is in the first position, and the subsequent administration of such medical liquid from the syringe through the outlet port of the valve when the control member is in the second position, e.g. administration via a vascular catheter access port.  
         [0016]     Further, the control member may be provided for selective positioning in a third position wherein a third flow path is defined between a second inlet port and the needle-less syringe. Such functionality allows for the use of the syringe to draw a second medical liquid (e.g. a second flush solution) through the second inlet port when the control member is in the third position, and the subsequent administration of the medical liquid through the outlet port of the valve when the control member is in the second position.  
         [0017]     Of note, the valve may also include a third inlet port, wherein when the control member is in the second position a fourth flow path is defined to allow a third medical liquid (e.g. a liquid medication or drug) to be passed directly through the third inlet port to the outlet port of the valve, wherein the third medical liquid is administered to a patient, e.g. via a vascular catheter access port. In such an arrangement the second and fourth flow paths are fluidly interconnected and partially overlap.  
         [0018]     In another aspect, a valve may be provided which includes a plurality of valve ports, including the syringe port and first and second valve inlet ports having corresponding center axes in offset first and second planes, respectively. Further, the control member may be positionable to provide any selected one of a plurality of flow paths between a corresponding plurality of different sets of the valve ports. More particularly, the control member may be provided with an internal passageway extending between a plurality of apertures in the control member, wherein a first aperture and a second aperture have corresponding center axes lying in said offset first and second planes, respectively. That is, the center axes of the first valve port and first aperture may be disposed within a common first plane, and the center axes of the second valve port and second aperture may be disposed within a common second plane. Moreover, the first and second planes may be substantially parallel. Such an arrangement allows multiple flow paths to be defined in a relatively simple manner. For example, in one embodiment at least a portion of the control member may be rotatably disposed in the valve, wherein such portion includes the first and second apertures.  
         [0019]     In conjunction with this aspect, a first set of valve ports may be disposed in a first relative relationship and a different second set of valve ports may be disposed in a second relative relationship, said first and second relative relationships being different. Correspondingly, a first set of control member apertures may be disposed in said first relative relationship and a second set of control member apertures may be disposed in a said second relative relationship. Further, the first and second sets of apertures may each include at least one aperture in common.  
         [0020]     As should be noted, the described administration apparatus allows up to three different medical liquid sources to be concurrently interconnected to three different inlet ports and separately administered through a common outlet port in a closed system, wherein the interconnected syringe is employable for the receipt and administration of the medical liquids. In the later regard, the outlet port may be selectively interconnected to a vascular catheter access port (e.g. via an interconnected tubing line having a male luer connector). By way of primary example, the invention allows for the sequential administration of a liquid medication, or drugs, and two different flush solutions via a closed system and pursuant to the establishment of a single vascular catheter interconnection.  
         [0021]     Additional features may be provided in combination with the above noted apparatus. For example, the syringe port and an end aperture of the control member may be disposed in opposing, aligned relation on the center axis of the valve. Further, the control member may be provided with a plurality of side apertures that may be selectively aligned with different ones of a plurality of valve side ports. As will be appreciated, the side apertures of the control member may be disposed for selective blockage by internal sidewalls of the valve in certain positions.  
         [0022]     Additionally, the medical liquid administration apparatus may include one or more indicators for identifying the optional fluid flow paths through the valve. For example, such indicator(s) may include visual path identifiers (e.g. corresponding with intended liquid medication and first/second solution source interconnections) located in spatial relation to inlet/outlet ports of the valve. The syringe may also be oriented transverse to a center axis of the valve, wherein the syringe may be selectively positioned in substantial alignment with a given one of the valve ports to affect a desired fluid flow path through the valve.  
         [0023]     In yet another feature, the syringe of the administration apparatus may include a syringe body, a plunger having a bottom end disposed in a top end of the syringe body, and a sealing member for sealing the top end of the syringe body to the plunger. More particularly, the sealing member may extend from a top end of the syringe body to a top end of the plunger. By way of example, the sealing member may comprise a flexible membrane that functions in a bellows-like manner.  
         [0024]     Various capabilities accommodated by the inventive administration apparatus may be implemented in an inventive method for medical liquid administration. In one aspect, the inventive method includes the steps of fluidly interconnecting a first flush solution source to a first inlet port of an administration apparatus, a second flush solution source to a second inlet port of the administration apparatus, and a liquid medication source to a third inlet port of the administration apparatus. The method further includes the step of passing a selected one of the flush solutions into a syringe of the administration apparatus. Of course, the inventive method may further include the step of flowing the selected flush solution from the syringe through an outlet port of the administration apparatus for administration to a patient, e.g. via a vascular catheter access port to a patient. Additionally, the method may include the step of infusing liquid medication by passing the liquid medication from the liquid medication source into the third inlet port and out of outlet port of the administration apparatus for administration to a patient, e.g. via a vascular catheter access port to a patient. Of note, a common outlet port is utilized for both flush solution and liquid medication administration.  
         [0025]     As may be appreciated, the inventive method may further include the steps of passing and flowing of a selected flush solution both prior to and after the liquid medication infusing step. In this regard, the first flush solution may be selected for said passing and flowing steps prior to the infusing step, and the second flush solution may be selected for the passing and flowing steps after said infusing step. More particularly, the first flush solution may include a saline solution and the second flush solution may comprise a heparin solution.  
         [0026]     In multiple-dose applications, the inventive method may include repeating the passing, flowing and infusing steps a desired number of times, while maintaining at least one of the fluid interconnections at the first, second and third inlet ports of the medical liquid administration apparatus. Moreover, the passing, flowing and infusing steps may be repeated any number of times while maintaining all three of the medical liquid source/inlet port interconnections. The maintenance of such interconnections yields sterility benefits as well as reduced procedural requirements.  
         [0027]     In conjunction with multiple-dose applications, the inventive method may further include the steps of interconnecting the outlet port of the administration apparatus to a vascular catheter access port to a patient, completing the flowing and infusing steps noted above, and disconnecting the outlet port of the medical liquid administration apparatus from the vascular catheter access port to the patient. In turn, the interconnecting, completing and disconnecting steps may be repeated a number of times. As will be appreciated, such steps accommodate the ambulatory needs of a patient receiving medication therapy over an extended time period, while also reducing the overall member of vascular catheter interconnections/disconnections required for liquid medication infusion and pre/post flushing procedures.  
         [0028]     In relation to the step of passing a selected flush solution into the syringe, such step may include a selected one of establishing: (i) a first closed flow path between the first inlet port and syringe, and (ii) a second closed path between the second inlet port and the syringe. Further, the step of flowing the selected flush solution to a vascular catheter access port may provide for the establishment of a third flow path between the syringe and the outlet port. The noted methodology may be implemented so that only one of the first, second or third flow paths is establishable at a given time. Further, the noted establishment of first, second or third flow paths may be selectively established via the rotation of a control member within a valve of the administration apparatus. Further, such rotating step may include the alignment of the syringe with one of the first, second and third inlet ports to establish a corresponding selected one of the first, second and third flow paths. Visual path identifiers (as noted above) may also be obscured in conjunction with the selection of a desired flow path.  
         [0029]     In completing the step of passing a selected flush solution into the syringe of the administration apparatus, the selected flush solution may be drawn by the retraction of a plunger relative to a barrel of the syringe. In turn, the step of flowing the selected flush solution out the outlet port, e.g. to a vascular catheter access port, may entail advancement of the plunger relative to the barrel of the syringe.  
         [0030]     As may be appreciated, the method may further provide for the retraction of the syringe plunger relative to the syringe barrel after at least one or both of the steps of flowing the selected flush solution or infusing the liquid medication. In conjunction with such retraction, the method may also include the step of observing fluid drawn from a patient towards a vascular catheter access port, wherein a proper fluid interconnection at the vascular catheter may be confirmed.  
         [0031]     Additional aspects and advantages of the present invention will become apparent to those skilled in the art upon consideration of the further description provided hereinbelow. 
     
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       [0032]      FIG. 1A  is perspective view of one medical liquid administration apparatus embodiment comprising the present invention.  
         [0033]      FIG. 1B  is a top view of the administration apparatus embodiment of  FIG. 1A .  
         [0034]      FIG. 1C  is a front view of the administration apparatus embodiment of  FIG. 1A .  
         [0035]      FIG. 1D  is a side view of the administration apparatus embodiment of  FIG. 1A .  
         [0036]      FIG. 2  is a cross-sectional side view of the administration apparatus embodiment of  FIG. 1A , with a syringe thereof shown in a first position.  
         [0037]      FIGS. 3A and 3B  are perspective and top views of the administration apparatus embodiment of  FIG. 1A , as interconnected to a liquid medication source and a first flush solution source, with two flow paths being defined by the medical liquid administration apparatus.  
         [0038]      FIG. 3C  is a side cross-sectional view of the administration apparatus embodiment and liquid medication source shown in  FIGS. 3A and 3B , as taken along line AA of  FIG. 3A .  
         [0039]      FIGS. 4A and 4B  are perspective and top views of the administration apparatus embodiment of  FIG. 1A , as interconnected to a liquid medication source and a first flush solution source, with another flow path being defined by the administration apparatus.  
         [0040]      FIGS. 5A and 5B  are perspective and top views of the administration apparatus embodiment of  FIG. 1A , as interconnected to a liquid medication source and first and second flush solution sources, with yet another flow path being defined by the administration apparatus.  
         [0041]      FIGS. 6A-6H  are schematic illustrations showing various selected flow paths definable by the administration apparatus embodiment of  FIG. 1A  in accordance with one method embodiment of the present invention. 
     
    
     DETAILED DESCRIPTION  
       [0042]      FIGS. 1A-1D  and  2  illustrate one medical liquid administration apparatus embodiment comprising various features of the present invention. The administration apparatus  1  includes a valve  10  and a syringe  70  fluidly interconnected to the valve  10 . As best shown by  FIG. 2 , the valve  10  includes a control member  20  rotatably disposed within a valve housing  30 . The control member  20  may be selectively rotated relative to valve housing  30  to provide a number of flow paths through the valve  10 .  
         [0043]     In this regard, valve housing  30  is provided with side ports  32 ,  34 ,  36 ,  38 , as well as a syringe port  40 . Control member  20  includes an internal passageway  50  that extends between apertures  52 ,  54  and  56 . As will be further described, apertures  54  and  56  are disposed to provide for the selective passage of medical liquids between side ports  34  and  38 , and syringe port  40 . Apertures  52  and  56  are disposed to provide for the selective passage of medical liquids between syringe port  40  and side port  36 . Apertures  52  and  54  are further disposed to provide for the direct passage of a medical liquid between side port  32  and side port  36 .  
         [0044]     The syringe  70  may be fixedly interconnected through syringe port  40  to the control member  20 , e.g. via an interconnection member  60 , for clockwise and counterclockwise co-rotation with the control member  20 . In one arrangement, a cylindrical end of control member  20  may be located and adhered within a complimentary, annular groove of the interconnection member  60  to achieve interconnection. A fluid opening  62  may be defined through the interconnection member  60  to fluidly interconnect aperture  56  and a fluid port  72  of the syringe  70 .  
         [0045]     As noted, various flow paths through valve  10  may be selectively established. Such capability allows medical liquid administration apparatus  1  to be utilized for the administration of three (3) different medical liquids, e.g. via an interconnectable vascular catheter access port. Furthermore, integration of syringe  70  in medical liquid administration apparatus  1  facilities the administration of a medical liquid from one or a plurality of interconnected sources (e.g. containing different flush solutions) on a successive, repeated basis during the course of medication therapy for a given patient. In particular, medical liquid administration apparatus  1  may be employed for the successive administration of a catheter flush solution, such as a saline solution and/or heparin solution, before and/or after liquid medication infusions, wherein at least one of the flush solutions is contained in an interconnectable reservoir of sufficient volume to dispense multiple flush solution dosages.  
         [0046]     Referring now to  FIGS. 1A-1D  and  2 , the spatial relationships between valve ports  32 ,  34 ,  36 ,  38 ,  40  and apertures  52 ,  54  and  56  of control member  20  will be described. In particular, valve side ports  32 ,  34 ,  38  have corresponding center axes disposed in a common first plane, and valve side port  36  has a center axis disposed in a second plane offset from and parallel to the first plane. Correspondingly, control member  20  is disposed within valve housing  30  so that the center axes of apertures  52 ,  54  are disposed in said offset first plane and second plane, respectively. Further, valve port  40  and aperture  56  are disposed in opposing aligned relation on a center axis of valve housing  30 .  
         [0047]     In connection with the foregoing, and as best shown in  FIG. 1B  and  FIG. 2  it should also be noted that the center axes of the valve side ports  32 ,  34 ,  36 ,  38  and the center axes of apertures  52 ,  54  of control member  20  are disposed to facilitate various aligned relationships therebetween. In particular, the center axes of coplanar ports  32 ,  34  and  38  are offset at 90° intervals about the center axis of valve housing  30 . On the other hand, apertures  52  and  54  of control member  20  are offset 180° about the center axis of valve housing  30 .  
         [0048]     By virtue of noted relative relationships, control member  20  may be rotatably positioned relative to valve housing  30  to selectively provide for the passage of liquid between port  34  and port  40  in a first position, between port  38  and port  40  in a second position, and between port  40  and port  36  in a third position. Additionally, when in the third position control member  20  also provides for direct passage of liquid between port  32  and port  36 . Further in this regard, it should be noted that when the control member  20  is positioned in each of the first and second positions, aperture  52  is blocked by an internal sidewall of valve housing  30 , thereby preventing the passage of liquid therethrough.  
         [0049]     In addition to the above-noted features, administration apparatus  1  may further include flow path indication, sterility maintenance and fluid interconnection features. In particular, administration apparatus  1  may include visual representations disposed in spatial relation to valve side ports  32 ,  34 ,  36  and  38  that correspond with the intended fluid interconnections. For example, as shown in  FIGS. 1A and 1B  the letters “S”, “A” and “H” may be disposed in spatial relation to ports  34 ,  32  and  38 , respectively, wherein the “S” port  34  is intended for fluid interconnection with a saline flush solution source, the “A” port  32  is intended for fluid interconnection with a liquid medication source, and the “H” port  38  is intended for fluid interconnection with a heparin flush solution source. As further shown by  FIGS. 1A and 1B , the visual representation “Cath” is provided in spatial relation to valve side port  36 , wherein the “Cath” port  36  is intended for fluid interconnection with a patient, e.g. a vascular catheter access port to a patient. In medical liquid administration apparatus  1 , the various visual representations noted above are provided on web members  80 . Certainly, other embodiments may utilize alternate visual representations disposed in other locations, e.g. directly on port extension members.  
         [0050]     In conjunction with the foregoing, it should also be noted that syringe  70  is disposed transverse to the center axis of the valve  10  (e.g. substantially parallel to the center axes of the various valve side ports  32 ,  34 ,  36 ,  38 ), wherein syringe  70  is rotatable about the center axis of the valve  10  to obtain the desired flow path through valve  10 . That is, by rotating syringe  70  over and into an aligned relation with a given one of the valve side ports  32 ,  34  and  38 , the fluid flow path corresponding with such valve side port may be achieved. In this regard, valve  10  may be provided so as to mechanically restrict the rotatable positioning of control member  20  to an arc that extends between ports  32 ,  34  and  38  (e.g. at least 180°) but which does not extend by port  36 . For example, and as best shown by  FIG. 1D , valve housing  30  may include an upstanding stop member  39  that extends into a cut-out region of a bottom skirt  62  of interconnection member  60 . In turn, rotation of the interconnection member  60  and control member  20  is limited to the arc defined by the cut-out region of interconnection member  60 . To facilitate aligned positioning of control member  20 , valve housing  30  may also include an upstanding detent member  39  having a rounded top end for receipt by a complimentary depression (e.g. hemispherical) in the bottom skirt  62  of the interconnection member  60 . As will be appreciated, when control member is rotatably positioned into the above-noted third position (e.g. to define passageways between ports  40  and  36  and between ports  32  and  36 ), the rounded top end of detent member  39  will slidably pass into the complimentary depression of bottom skirt  62 .  
         [0051]     To facilitate repeated use of the syringe  70  during a given medication therapy, syringe  70  is provided with a sealing member  74  for maintaining sterility. More particularly, the sealing member  74  may extend over the top end of the plunger  76  and interconnected with the syringe body  78 , e.g. via a securing ring  90  interconnected to a top end of the syringe body  78 . Sealing member  74  may be a collapsible membrane that functions in a bellows-like manner to facilitate advancement and retraction of plunger  76  relative to syringe body  78 . As will be appreciated, the provision of sealing member  74  maintains the sterility of the inside surfaces of the syringe body  78  during use.  
         [0052]     More generally in this regard, it may be appreciated that the medical liquid administration apparatus  1  may be packaged in a sterile condition. For example, the administration apparatus  1  may be assembled, packaged in a heat-sealed enclosure, and sterilized via exposure to gamma radiation.  
         [0053]     As shown in phantom in  FIG. 2 , a catch member  92  may also be provided with administration apparatus  1 . For example, catch member  92  may be interconnected to or comprise a further feature of securing ring  90 . In use, the catch member  92  may be employed to selectively restrict retraction of plunger  76  relative to syringe body  78 . Such feature may be of particular use during use of the administration apparatus  1  for liquid medication administration. Of course, catch member  92  may also be deflected outward to permit use of the plunger  76 , as will be described.  
         [0054]     As indicated, the medical liquid administration apparatus  1  may be further provided with a number of features to facilitate various intended fluid interconnections. In particular, and as best shown by  FIGS. 1A-1D ,  3 A,  4 A and  5 A, administration apparatus  1  may be provided with a tubing line  122  connected to valve side port  34 . In turn, tubing line  122  may be directly connected to a first flush solution source  120  (e.g. a saline solution reservoir) or may be provided with a spike member  124  for selective interconnection to a vial or other reservoir containing a first flush solution (e.g. saline flush solution). Administration apparatus  1  may also be provided with a lure connector  102  (e.g. a female luer connector having a removable cap) connected to valve side port  32  for selective interconnection with a complimentary lure connector  104  (e.g. a male luer connector) that is provided at one end of a tubing line  106  fluidly interconnected to a liquid medication source  100 . A clip  108  may be provided on tubing line  106  for selective occlusion of tubing line  106 . Administration apparatus  1  may also be provided with a lure connector  142  (e.g. a female luer connector having a removable cap) connected to valve side port  38  for selective interconnection with a complementary lure connector  146  (e.g. a male luer connector) provided at one end of a tubing line  144  interconnected with a second flush solution source  140  (i.e. a heparin flush solution). Finally, administration apparatus  1  may also be provided with a tubing line  162  connected to valve side port  36  and having a male lure connector  164 , e.g. provided for selective interconnection with a complementary female luer connector comprising a vascular catheter access port  160  to a patient.  
         [0055]     Such various fluid interconnection features will now be further described in relation to intended exemplary applications. With specific reference to  FIGS. 3A, 3B  and  3 C, the administration apparatus  1  is shown with syringe  70  located in a position to define a flow path between the liquid medication source  100  and vascular catheter access port  160  via valve ports  32  and  36 . To administer liquid medication, the liquid medication source  100  may be controlled to infuse the medical liquid into the vascular catheter access port  160 . For example, when liquid medication source  100  comprises a syringe, the plunger may be advanced relative to the barrel thereof to achieve administration. In one approach, the liquid medication source  100  may be mounted in an automated device  110  for automated dispensation of pre-selected dosage amounts. As noted above, during liquid medication administration the optional catch member  92  may be positioned to restrict retraction of the syringe plunger  76 . Preferably, clip  108  is manipulated to occlude, or close, tubing line  106  during all periods between liquid medication administrations.  
         [0056]     When syringe  70  is located in the position shown in  FIGS. 3A, 3B  and  3 C, a flow path is also defined between syringe  70  and vascular catheter access port  160  via valve ports  40  and  36 . As will be described, such position is employed to administer first or second flush solution amounts drawn into syringe  70 .  
         [0057]     In that regard, and referring now to  FIGS. 4A and 4B , syringe  70  is shown in a position that provides a fluid flow path between the first flush solution source  120  and syringe  70  via valve ports  34  and  40 . To facilitate the passage of the first flush solution into the syringe  70 , plunger  76  is retracted so as to draw the flush solution through the tubing line  122  and valve  10  into the syringe body  78 . To administer the first flush solution from the syringe body  78 , syringe  70  is rotated into the position shown in  FIG. 3A-3C . Thereafter, plunger  76  may be advanced so as to flow the flush solution through valve ports  40 ,  36  to the vascular catheter access port  160 .  
         [0058]     A similar procedure may be followed for optional usage of the second flush solution source  140 . More particularly, and referring now to  FIGS. 5A and 5B , syringe  70  is shown in a position that provides a fluid path between the second flush solution source  140  and syringe  70  via valve ports  38  and  40 . In this position plunger  76  of syringe  70  may be retracted to draw flush solution from source  140 . Then, syringe  70  may be rotated to the position shown in  FIGS. 3A-3C  for infusion of the second flush solution through vascular catheter access port  160 .  
         [0059]     Of note, it should be appreciated that, prior to or after the infusion of a liquid medication or flush solution, administration apparatus may be conveniently employed for effective vascular catheter aspiration. In particular, syringe plunger  76  may be retracted to manually draw a small amount of blood through an interconnected vascular catheter and into tubing line  166  to allow medical personnel to confirm proper catheter placement and/or the absence of blood clotting. Then, syringe plunger  76  may be advanced to return the blood.  
         [0060]     An exemplary procedure using the medical liquid administration apparatus  1  will now be presented. To begin the procedure the liquid administration apparatus  1  is removed from sterile packaging and set-up procedures completed. In particular, and with reference to  FIGS. 3A, 4A  and  5 A, a vascular catheter access port  160  may be fluidly interconnected to the medical liquid administration apparatus  1  via male luer connector  164 , tubing line  162  and valve side port  36 . Further, liquid medication source  100  may be fluidly interconnected to side port  32  of the medical liquid administration apparatus  1 , and source  100  may be optionally positioned within an automated infusion device  110  as deemed appropriate by medical personnel. To complete the set-up procedure, a saline flush solution source  120  and/or heparin flush solution source  140  may be fluidly interconnected to valve side port  34  and/or valve side port  38  of the medical liquid administration apparatus  1 . At this point, all necessary fluid interconnections have been made to allow for the use of medical liquid administration apparatus  1  on a repeated basis over the course of an extended medication therapy.  
         [0061]     Following setup, various tubing lines comprising the various fluid interconnections may be primed by sequentially positioning and control of syringe  70  to define and draw liquid through the desired fluid flow path to be primed both upstream of the medical liquid administration apparatus  1  and downstream thereof. Tubing line  106  may be primed by manipulation or automated control of liquid medication source  100 . Next, a vascular catheter (not shown) interconnected via tubing line  166  to vascular catheter access port  160  may be inserted into a patient. Then, syringe  70  may be employed to aspirate the vascular catheter.  
         [0062]     Reference is now made to  FIG. 1A  and  FIGS. 6A-6H . When medical personnel determine that it is an appropriate time to provide a dose of liquid medication, the syringe  70  may be aligned with port  34  to define a fluid flow path between the saline flush solution source  120  and the syringe  70  via valve  10 , see  FIG. 6A . Medical personnel may then pass a desired volume of the saline flush solution into the syringe  70  via retraction of plunger  76 . Next, medical personnel may locate the syringe  70  into an aligned orientation with port  36 , see  FIG. 6B . The plunger  76  may then be advanced to flow the saline flush solution through the valve  10  and into the vascular catheter access port  160  to the patient. Of note, plunger  76  may then be retracted a sufficient amount to allow medical personnel to visually confirm a blood return into the vascular catheter access port tubing line  166 , see  FIG. 6C . Upon such confirmation, plunger  76  may be advanced to push the blood back into the patient.  
         [0063]     Next, medical personnel may position the syringe  70  in an aligned orientation with valve side port  32 , see  FIG. 6D . Concomitantly, clip  108  may be positioned to open the tubing line  106  and a predetermined, desired amount of liquid medication may be passed from liquid medication source  100  into vascular catheter access port  160  via manipulation or automated control of liquid medication source  100 . Clip  108  may then be repositioned to occlude tubing line  106 . Again, plunger  76  may be retracted a sufficient amount to allow medical personnel to visually confirm a blood return into the vascular catheter access port tubing line  166 . Upon such confirmation, plunger  76  may be advanced to push the blood back into the patient.  
         [0064]     When the desired liquid medication infusion is complete, medical personnel may rotate the syringe  70  into an aligned position with port  34 , see  FIG. 6F . A desired volume saline flush solution may be drawn from source  120  into the syringe  70 . Syringe  70  may then be rotated back into an aligned position with port  32 , see  FIG. 6G , and plunger  76  advanced to affect passage of the saline flush solution through the administration apparatus  1  to vascular catheter access port  160 . Medical personnel may then slightly retract plunger  76  to again visually confirm a blood return within the vascular access port tubing  166 , as per  FIG. 6C , and thereafter push the blood back into the patient.  
         [0065]     As may be appreciated, when use of the heparin flush solution from source  140  is desired, the syringe  70  may be oriented in an aligned relation with a port  38 , see  FIG. 6H . Thereafter, the heparin flush solution may be passed into the syringe  70  and subsequently infused by rotating the syringe  70  into an aligned orientation with port  32 , see  FIG. 61 , and advancing plunger  76 .  
         [0066]     After a given infusion of liquid medication is completed, the valve side port  36  of medical liquid administration apparatus  1  may be selectively disconnected from the vascular catheter access port  160 , e.g. male luer connector  164  may be disconnected and covered. For example, the male luer connector  164  may be temporarily docked within a docking apparatus such as that described in U.S. patent application Ser. No. 10/226,183, entitled “STERILE DOCKING APPARATUS AND METHOD”, filed Aug. 22, 2002, hereby incorporated by reference in its entirety.  
         [0067]     When a further infusion of liquid medication is desired, the male lure connector  164  may be uncovered. The male luer connector  164  and vascular catheter access port  160  may then be swabbed with an appropriate anti-bacterial solution and reconnected. Thereafter, the procedure may continue as per the description accompanying  FIGS. 6A-6H  above.  
         [0068]     In accordance with described arrangement, multiple infusions of liquid medication may be completed utilizing medical liquid administration apparatus  1 , while maintaining fluid interconnections between the medical liquid administration apparatus  1  and saline flush solution source  120 , liquid medication source  100  and/or heparin flush solution source  140 . As may be appreciated, the maintenance of one or more such interconnections simplifies the overall procedure for medical personnel, results in reduced waste relative to prior techniques, and enhances the maintenance of sterile interconnections.  
         [0069]     The embodiments described above are for exemplary purposes only and is not intended to limit the scope of the present invention. Various adaptations, modifications and extensions of the described system/method will be apparent to those skilled in the art and are intended to be within the scope of the invention as defined by the claims which follow.