Abstract:
A process is disclosed for performing encapsulation, en masse, by an in situ polymerization reaction to yield capsule wall material. The polymerization includes a reaction between urea and formaldehyde or polycondensation of monomeric or low molecular weight polymers of dimethylol urea or methylated dimethylol urea in an aqueous vehicle and the reaction is conducted in the presence of negatively-charged, carboxyl-substituted, linear aliphatic hydrocarbon polyelectrolyte material dissolved in the vehicle. Liquid-liquid phase separation is accomplished and maintained by increase in the molecular weight of the resulting condensation polymer without further dilution of the manufacturing vehicle. The negatively-charged polyelectrolyte material is required and has an apparent effect of controlling or modifying the polymerization reaction. The disclosed encapsulation process permits manufacture of microcapsules in concentrations of capsule to capsule manufacturing vehicle higher than previously possible.

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
     This application is a continuation-in-part of copending application Ser. No. 487,322, filed on July 10, 1974, now U.S. Pat. No. 4,001,140. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     This invention pertains to a process for manufacturing minute capsules, en masse, in a liquid manufacturing vehicle. The process involves liquid-liquid phase separation of a relatively concentrated solution of polymeric material to be used in the formation of walls for the minute capsules. 
     En masse processes for the manufacture of microcapsules have generally required large amounts of liquid manufacturing vehicle and have generally resulted in low yields of capsules. An encapsulating system and process which utilizes relatively small amounts of manufacturing vehicle to generate relatively large amounts of microcapsules would be valuable from several viewpoints. For example, costs of transporting the capsule product, as manufactured, would be reduced because the product contains less vehicle. As another example, in the case where the capsule product is to be coated to a dried film on a sheet substrate coating costs are reduced because there is less liquid vehicle to be removed from the substrate. 
     Many combinations of materials have been used in the past in search of compositions which yield certain physical characteristics in capsule walls or which permit performing the encapsulating process under certain desired or required conditions. As examples of desirable capsule characteristics, small size, impermeability of capsule walls to diffusion and strength of capsule walls to withstand normal handling forces can be mentioned. As examples of desirable process conditions, relatively high pH, relatively short times, and relatively high yield and concentration are important. 
     It is, therefore, an object of the present invention to provide a capsule manufacturing process wherein capsules are produced in high yield and in increased concentration. It is, additionally, an object of the invention to provide a process which requires a relatively short time for completion and which utilizes process conditions of increased convenience. 
     It is, further, an object of the present invention to provide a process for manufacturing microcapsules, which microcapsules have capsule walls of increased impermeability. Additionally, it is an object of this invention to provide a process for manufacturing very small capsules having predominantly single-particle capsule core entities. 
     Specifically, it is an object of this invention to provide an encapsulating process wherein the capsule wall material comprises a polymer formed from a urea-formaldehyde, dimethylol urea or methylated dimethylol urea starting material wherein said wall material is generated by an in situ condensation reaction. It is, further, an object of this invention to provide such capsule wall material by an improved condensation reaction conducted in the presence of a negatively-charged, carboxyl-substituted, linear aliphatic hydrocarbon polyelectrolyte material dissolved in the capsule manufacturing vehicle. 
     2. Description of the Prior Art 
     South African Pat. No. 62/939 issued Mar. 6, 1972 and corresponding in most respects to U.S. Pat. No. 3,516,941, discloses a preparation of microcapsules by in situ polymerization of amides or amines and aldehydes. There is no disclosure of the use of a negatively-charged polyelectrolyte material to modify or otherwise affect the polymerization reaction or product. U.S. Pat. No. 3,516,941 contains disclosure of detrimental effects found in such encapsulating processes when certain wetting agents are used. 
     U.S. Pat. No. 3,755,190 issued Aug. 28, 1973 discloses a microencapsulating process wherein the capsule wall material is polyhydroxy phenolic/aldehyde polymeric material generated in the presence of poly(vinyl alcohol). 
     U.S. Pat. No. 3,726,803 issued Apr. 10, 1973 discloses microcapsules having a composite capsule wall structure of hydrophilic polymeric material interspersed by a hydrophobic polymeric material. The hydrophobic polymeric material is disclosed to be an in situ-generated condensate of a polyhydroxy phenolic material and an aldehyde. 
     U.S. Pat. No. 3,016,308 issued Jan. 9, 1962 discloses encapsulation by continued polymerization of urea/formaldehyde resin dissolved in an aqueous manufacturing vehicle with a polymeric wetting agent. The process utilizes urea/formaldehyde resin as starting material and a slight amount of wetting agent to maintain an emulsion during the continued polymerization. 
     SUMMARY OF THE INVENTION 
     The condensation polymer generated in an aqueous capsule manufacturing vehicle utilizing urea and formaldehyde, dimethylol urea (DMU) or methylated dimethylol urea (MDMU) as the starting material, results, without more, in brittle films of capsule wall material. The polymeric material generated from an aqueous solution of said starting materials to give a molecular weight adequate for phase separation has a tendency to separate from solution as a crystalline, nugget-like, solid. Such a precipitous phase separation can be controlled to yield a liquid separated phase relatively concentrated in the polymeric material, but the control involves frequent and critical dilutions to maintain proper polymer concentrations. An encapsulating process utilizing the generation of, for example, urea/formaldehyde and step-wise and continual dilution of the manufacturing vehicle does yield capsules of quality adequate for many intended uses despite the frangible and fragile nature of the capsule wall material. 
     While dilution of the manufacturing vehicle in previously-developed encapsulating processes which utilize urea/formaldehyde polymer generation is required to alleviate the formation of solid nuggets of polymeric material, dilution is also required to maintain the encapsulating system at a workable viscosity. Urea/formaldehyde polymeric material possesses some desirable qualities for use in microcapsule wall material; but previously-disclosed processes have required substantial improvement for generating the polymeric material in commercially-acceptable quantity and quality in the context of microcapsule manufacture. 
     The process of the present invention provides for the manufacture of capsule walls from the polymerization of urea and formaldehyde, dimethylol urea or methylated dimethylol urea with the benefits of a well-formed condensation polymer but without the disadvantages of required dilution and nugget formation, which has plagued prior processes. In regard to these matters of dilution and nugget formation, it is important to note that the encapsulating process of the present invention is conducted effectively and preferably at capsule concentrations higher than previously believed possible. Moreover, at those higher capsule concentrations, in the present process, the system viscosity remains within effective and operable liquid limits. 
     Additionally, the process of the present invention results in the manufacture of capsule walls which are relatively impermeable and strong, particularly as compared to the capsule walls of urea/formaldehyde polymer made in accordance with previously-known processes. 
     A system component material specially utilized in the present process, which material is believed to be required for realizing any and all of the benefits described herein, is a negatively charged polymeric polyelectrolyte material having a linear aliphatic hydrocarbon backbone with an average of about two carboxyl (or anhydride) groups for every four to six backbone carbon atoms. Use of the proper kind and amount of this system modifier is necessary to permit the manufacture of microcapsules having urea/formaldehyde, DMU or MDMU wall material in a high capsule concentration, a low vehicle viscosity, and at a beneficially high pH condition. 
     Poly(vinyl alcohol) has been used, previously, as a supporting polymer in generation of certain, specific, condensation polymers in processes of microencapsulation. The condensation polymer in those processes is a product of an aldehyde and polyhydroxy phenolic materials having at least two phenolic hydroxy groups. However, poly(vinyl alcohol) is disclosed as the only eligible supporting polymer and only phenolic materials having at least two phenolic hydroxy groups are disclosed to be used as coreactants for the aldehyde. 
     The present invention provides means to use urea/formaldehyde, dimethylol urea or methylated dimethylol urea as starting materials to form condensation polymers as capsule walls and to obtain the benefits therefrom without the previously-disclosed disadvantages. The dimethylol urea or methylated dimethylol urea starting materials can be used in the monomeric form or as a low molecular weight polymer thereof, and reference thereto in the present application includes all of these forms. The system modifier of this invention, in some respects, shares similarities with the poly(vinyl alcohol) supporting polymer discussed above. The system modifier of this invention is, however, required to have a carboxyl negative charge in aqueous solution; and even more specifically, only certain carboxyl-substituted materials have been found eligible. While the inventors do not believe that the system modifier forms any strong complex or substantial combination with the starting materials prior to polymerization, it is believed that the modifier interferes, in some manner, with the polymerization reaction. The mechanism of the interference is not understood, but the effect of the interference is to permit manufacture of microcapsules, en masse, by in situ polymerization at a surprisingly high concentration with surprisingly low viscosity in the manufacturing vehicle. 
     The system modifier is not included in the finished capsule walls in appreciable amounts. The system modifier takes some active part in the resulting polymerization reaction as is evidenced by reduced viscosity of the system at increased polymer concentration and increased efficiency of the polymerizing component materials with increased optimum pH of polymerization. Nevertheless, the finished capsule walls retain only a minor residual amount of the system modifier. To be effective, the system modifier must be included in the encapsulating system before the commencement of the polycondensation reaction. The characteristic brittleness of the resulting polymeric capsule wall material is alleviated somewhat by that residue of modifier; and the effect, in most cases, is a fortuitous benefit. 
     Examples of eligible carboxyl group system modifiers include hydrolyzed maleic anhydride copolymers, which are preferred, such as poly(ethylene-co-maleic anhydride) (EMA), poly(methyl vinyl ether-co-maleic anhydride) (PVMMA), poly(propylene-co-maleic anhydride) (PMA), poly(isobutylene-co-maleic anhydride) (iBMA), poly(butadiene-co-maleic anhydride) (BMA), poly(vinyl acetate-co-maleic anhydride) (PVAMA), and the like; and polyacrylates, such as poly(acrylic acid), and the like. 
     In further regard to the preferred system modifiers, there appears to be a molecular weight range within which the best results are obtained. Eligible system modifiers permit and maintain the encapsulating system of polymerizing urea and formaldehyde, DMU or MDMU at reasonably low and workable viscosities. Negatively-charged materials which would otherwise be eligible as system modifiers, are ineligible at molecular weights which are too low. Inexplicably, system modifier materials below a certain molecular weight cause the system to thicken and gel, while materials of an adequately high molecular weight maintain the system viscosity at an acceptable low level. The viscosity effect is not understood, and no explanation is offered, for the low viscosity using high molecular weight system modifiers and the high viscosity using low molecular weight system modifier materials. The critical molecular weight is not represented by a sharp change from eligibility to ineligibility but by a transition from preferred to viscous to gelled as the molecular weight is decreased. The critical low molecular weight appears, also, to vary somewhat with different kinds of the eligibile system modifier materials. For example, preferred poly(ethylene-co-maleic anhydride) should have a molecular weight above about 1000; poly(methylvinylether-co-maleic anhydride) above about 250,000; poly(acrylic acid) above about 20,000. 
     Material contained within the capsule walls formed in accordance with this invention, i.e., the capsular internal phase or capsule core material, is relatively unimportant to the practice of the invention and can be any material which is substantially water-insoluble and which does not interact with the intended capsule wall material, or with other encapsulating-system components, to the detriment of the process. A few of the materials which can be utilized as capsule internal phases include, among a multitude of others: water-insoluble or substantially water-insoluble liquids such as olive oil, fish oils, vegetable oils, sperm oil, mineral oil, xylene, toluene, kerosene, chlorinated biphenyl, and methyl salicylate; similar substantially water-insoluble materials of a solid but meltable nature such as naphthalene and cocoa butter; water-insoluble metallic oxides and salts; fibrous materials, such as cellulose or asbestos; water-insoluble synthetic polymeric materials; minerals; pigments; glasses; elemental materials including solids, liquids and gases; flavors, fragrances; reactants; biocidal compositions; physiological compositions; fertilizer compositions; and the like. 
     The process of this invention specifically and preferably includes as one embodiment the steps of establishing an aqueous, single-phase, solution of the system modifier and urea into which is dispersed the intended capsule core material (substantially insoluble in the solution and substantially chemically unreactive with any of the solutes). The dispersing forces are maintained, formaldehyde is added to the system and, on reaction between the urea and the formaldehyde, a urea/formaldehyde polymeric material separates from the solution as a liquid solution phase, in its own right, relatively highly concentrated in urea/formaldehyde. The separated liquid phase containing urea/formaldehyde wets and enwraps particles of the dispersed capsule core material to yield liquid-walled embryonic capsules. Continued reaction of the urea/formaldehyde material, preferably with agitation such as stirring, yields solid and substantially water-insoluble capsule walls. Agitation is not required for the condensation reaction to proceed. It is important to note that: (a) after makeup of the system and commencement of the capsule-wall-forming condensation reaction, there is no dilution step in the process; (b) the presence of the system modifier permits generation of a high concentration of urea/formaldehyde polymer at a relatively low viscosity; (c) the resulting high concentration-low viscosity system permits liquid phase separation and subsequent polymerization to a solid to produce capsules, en masse, in a, by volume, concentration in the manufacturing vehicle not before possible. 
     In another embodiment of the invention, an aqueous, single-phase solution of dimethylol urea or methylated dimethylol urea and said system modifier or supporting colloid is prepared, and the internal phase capsule core material is dispersed therein. Upon heating, preferably with agitation such as stirring, the condensation reaction proceeds to give a condensation polymer which separates from the solution as a liquid solution phase and wets and enwraps particles of the dispersed capsule core material to yield liquid-walled embryonic capsules, which eventually become solid and substantially water-insoluble capsule walls. 
     Alternatively, the various system components can be combined in any desired order with only the limitation that the system modifier must be present in the system at the time that the polymerization reaction begins. The capsule core material can be dispersed in the system at any time before the separated liquid phase of polymeric material becomes solid or is so polymerized that dispersed capsule core particles are not enwrapped by the resulting polymer. 
     The polymerization reaction, even as altered by the system modifier, is a condensation conducted in an acid medium. The condensation can be accomplished in an aqueous system having a pH of about 0 to 7, the time and temperature requirements being variable to optimize the reaction. As an effect of the system modifier and its relation to the condensation, the preferred pH for operation of this invention is from 2.5 to 5.0 and the most preferred pH is 3.5. 
     As to the relative amounts of urea and formaldehyde which should be used, it has been found that the molar ratio of formaldehyde to urea must be at least 1.6, and is preferably from 1.6 to about 3. 
     After the reaction has progressed to the point where the capsule walls have been solidified and, in that respect, the capsule manufacture is completed, the capsules can be separated from the manufacturing vehicle by filtering and washed with water. The capsule walls can then be dried by placing the capsules in a forced air dryer. It should be understood, however, that the capsules need not have dried walls or even be separated from the liquid vehicle prior to their use. If it is desired or required for some intended purpose, the capsule product of this invention can be supplied as a slurry of capsules in a liquid carrier, either the manufacturing vehicle or not, such as for use in a paper-coating composition, a paint, an insecticide composition, or the like, such uses being previously taught in the prior art. 
     Individual capsules prepared by the present invention are substantially spherical and can be manufactured having diameters of less than 1 micron to about 100 microns, the preferred size range being from about 1 to about 50 microns, in diameter. The capsule product of this invention can be made to take the form either of individual capsules with each entity having, as an internal phase, one particle of capsule core material or of aggregates of individual capsules with each aggregate entity having several particles of capsule core material. Capsule aggregates can be made in sizes from a few microns in diameter to several hundred microns in diameter depending upon the size and state of the included core material. 
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Unless otherwise specified, all percentage and part designations indicate percent and parts, by weight; and all temperature designations indicate degrees Centigrade. All solutions, unless otherwise designated, are aqueous solutions. 
     EXAMPLE 1 
     In this preferred example, negatively-charged poly(ethylene-co-maleic anhydride) is used to modify a urea/formaldehyde encapsulating system to yield capsules in the size range of 1 to 15 microns. The capsule contents comprise an oily solution of colorable dye materials for use in carbonless copying paper, as will be described below in relation to testing the capsule product of this example. The capsule contents is termed the &#34;internal phase&#34; herein. A suitable poly(ethylene-co-maleic anhydride) includes approximately equimolar ethylene and maleic anhydride and has a molecular weight of about 75,000 to 90,000 such as, for example, the product sold by Monsanto Chemical Company, St. Louis, Mo., under the trademark &#34;EMA-31&#34;. 
     Into a blending vessel having about a one liter capacity and equipped for agitation and heating are placed: 100 grams of a 10 percent aqueous solution of hydrolyzed poly(ethylene-co-maleic anhydride) as the system modifier; 10 grams of urea; 1 gram of resorcinol; and 200 grams of water, as the manufacturing vehicle. The pH is adjusted to 3.5 using 20 percent aqueous sodium hydroxide; and 200 milliliters of internal phase is emulsified into the manufacturing vehicle to yield mobile internal phase droplets of an average size of less than about 10 microns in a single-phase solution of the manufacturing vehicle. Twenty-five grams of formalin (37 percent aqueous formaldehyde solution) is added to the system. The agitation is maintained, the system is heated to about 55°, and under continued agitation, the temperature is maintained for about two hours and then permitted to decrease to ambient (about 25°). 
     This example utilizes a molar ratio of formaldehyde/urea of about 1.9 and contains about 6 percent of urea and formaldehyde and 3 percent of system modifier in the manufacturing vehicle (excluding consideration of the internal phase). The capsules of oily dye solution are uniformly in a size range of about 1 to 15 microns and represent more than 40 percent, by volume, of the encapsulating system. The oily dye solution comprises 3,3-bis-(4-dimethylaminophenyl)-6-dimethylaminophthalide (commonly known as Crystal Violet Lactone) and 3,3-bis-(1-ethyl-2-methylindol-3-yl) phthalide (sometimes known as Indolyl Red) in a mixture of solvents including a benzylated ethyl benzene and a relatively high-boiling hydrocarbon oil, such as one having a distillation range of 400-500 degrees Fahrenheit. 
     The capsule product from this example will be compared, below, with capsule products from the next two examples. 
     EXAMPLE 2 
     This example is identical with Example 1 with the exception that the system modifier is omitted from the manufacturing vehicle. The initial manufacturing vehicle composition is 10 grams of urea, 1 gram of resorcinol, and 300 grams of water and the materials and the procedure are otherwise unchanged. It should be noted that the colorable dye material encapsulated in this series of examples reacts to yield a colored reaction product and thereby becomes increasingly soluble in the manufacturing vehicle below a pH of about 2.7. To prevent such coloration of the dye, the system pH is kept above pH 2.7 and is preferably maintained at about 3.5. 
     This example also utilizes a molar ratio of formaldehyde/urea of about 1.9 and contains about 6 percent of urea and formaldehyde in the manufacturing vehicle. The capsule materials in this example represent more than 40 percent, by volume, of encapsulating system although the internal phase droplet size varies considerably (from about 5 up to as much as 300 microns) due to a lack of stability in the emulsification. It is noted that most of the capsule materials are not utilized;--the internal phase being unacceptably encapsulated and nuggets and solid particles of urea/formaldehyde polymer existing free in the system. 
     EXAMPLE 3 
     This example is identical with Example 1 with the exception that poly(vinyl alcohol) is substituted for the negatively charged, poly(ethylene-co-maleic anhydride). While the poly(vinyl alcohol) does appear to serve as an effective emulsifier or protecttive colloid to permit control of dispersed droplet size, it has no effect or perhaps even an adverse effect on the condensation reaction. Capsules are not formed in this example although the system evidences a large amount of undeposited solid material which results from the urea/formaldehyde reaction and is unuseable as capsule wall material. 
     EXAMPLE 4 
     This example is identical with Example 1 with the exception that poly(acrylic acid) is substituted for the poly(ethylene-co-maleic anhydride). Poly(acrylic acid) is among the eligible system modifiers in providing the beneficial effect on the urea/formaldehyde condensation. Control of the capsule size range has been found to be more difficult using poly(acrylic acid), but the capsule quality is comparable with that of Example 1. The capsules range in size from about 1 to 100 microns. A suitable poly(acrylic acid) may have an average molecular weight of more than about 150,000 and less than about 300,000 such as, for example, the product sold by Rohm and Haas Company, Philadelphia, Pa., under the trademark &#34;Acrysol A-3&#34;. 
     Because the size of capsules made in the above examples is so small and because the intended capsule use is in carbonless copying papers, the capsules of the above examples are tested by methods which relate to effectiveness in a copying paper use. As a general description, the capsules are coated onto a sheet termed a &#34;CB Sheet&#34; (sheet with Coated Back) and are tested in conjunction with a standardized sheet termed a &#34;CF Sheet&#34; (sheet with Coated Front). The coating of the CB Sheet includes about 75 percent capsules, 18 percent wheat starch, and 7 percent of gum binder such as, for example, the hydroxyethylether of corn starch or other water-soluble starch derivatives; and is made up by combining 100 parts of aqueous capsule slurry having 40 percent capsules, 125 parts of water, 10 parts of wheat starch and 40 parts of a 10 percent aqueous solution of the gum binder--all adjusted to about pH 9. The coating is cast using a wire-wound rod designed to lay a 20 pounds per ream (3300 square feet) wet film coating. 
     The coating of an exemplary CF Sheet includes a metal-modified phenolic resin reactive with the dyes, kaolin clay and other additives and a binder material. A CF sheet is described in U.S. Pat. No. 3,732,120. 
     When a CB Sheet and a CF Sheet are placed in coated face-to-coated face relation and pressure is applied, capsules of the CB Sheet rupture and capsule-contained material is transferred to and reacted with the acid component of the CF Sheet to yield a color. A test associated with such capsule rupture and color formation is Typewriter Intensity (TI) and TI values indicate ratios of reflectances--the reflectances of marks produced on the CF Sheet by a typewriter striking two sheets together versus the paper&#39;s background reflectance. A high value indicates little color development and a low value indicates good color development. ##EQU1## 
     Reflectances of a more-or-less solid block of print made with an upper-case &#34;X&#34; character and of the background paper are measured on an opacimeter within twenty minutes after the print is made, first, using freshly prepared CB Sheets and, then, using CB Sheets aged in an oven at 100 degrees. A small difference between the TI values indicates good capsule quality. After the oven aging, a TI value of 100 indicates complete loss of solvent from the capsules and a TI value less than 70 evidences acceptable capsules for these tests. When an initial TI value is less than 70, a TI value difference between initial and aged samples of less than about 5 is acceptable for these tests; but, of course, a difference of less than 3 is much preferred. 
     
         ______________________________________TI______________________________________    Initial    Aged (time)______________________________________Example 1  58           60 (one day)Example 2  96           100 (one hour)Example 3  81           100 (one hour)Example 4  47           47 (one day)______________________________________ 
    
     Of course, any convenient and reliable method for exhibiting comparative capsule quality can be used. In the above examples, it should be noted that the particular coating formulation or coating materials are neither critical nor important and can be varied or substituted, as desired or required to fit a particular situation. The resorcinol is not necessary and can be omitted or can be replaced by another material such as orcinol or gallic acid. If used, the resorcinol or other material can be present in the system in amounts of 5 to 30 percent, or more, based on the free or combined urea in the starting materials. 
     EXAMPLE 5 
     In this example, capsules are prepared at a high capsule solids concentration of more than 60 percent, by volume, capsules in only about 40 percent, by volume, of aqueous manufacturing vehicle. Forty parts of 10 percent aqueous system modifier solution, 20 parts of water, 4 parts of urea, and 90 parts of internal phase are combined under emulsifying agitation similar to that of previous examples. The pH is adjusted to about 3.5, the temperature is raised to about 55°, and the emulsification is continued to a droplet size of less than 10 microns. Ten parts of formalin is then added to the system and stirring is maintained for about three hours. The viscosity of the system increases considerably as the urea/formaldehyde polymerization reaction progresses. The viscosity appears to be a function of polymer growth and deposition onto capsule walls, however, because the encapsulating system does not show a tendency to gel so long as the system modifier is used. The system of this example can be permitted to stand without agitation after the first three hours of reaction; and the capsules will, nevertheless, remain individual and unagglomerated. The capsules are easily redispersed after settling in the manufacturing vehicle without agitation. 
     Results from tests on capsules prepared in this example are set out in the following table. Results are shown for capsules prepared using poly(ethylene-co-maleic anhydride) of two different molecular weights as system modifiers. The TI test results are identified by system modifier molecular weight. 
     
         ______________________________________     Initial            Aged 100 degreesMolecular Weight       TI       TI (1-3 days) (1 week)______________________________________15,000-20,000       56       58            5875,000-90,000       57       59            58______________________________________ 
    
     When the high concentration encapsulation is attempted by omitting the system modifier or by replacing the system modifier by a nonionic or a positively-charged polymer, no acceptable capsules are produced. For example, when poly(vinyl alcohol) is used, the results are much like those of Example 3, with the exception that, during the condensation reaction, the viscosity of the system increases so much that it cannot be poured without dilution, even at 55°. 
     EXAMPLE 6 
     In this example, three series of different system modifiers are used in accordance with the procedure generally described in Example 1. When the capsules contain the oily internal phase of dye solution described above; and, when the capsule quality is tested as above, the test results are: 
     
         ______________________________________           TISystem Modifier Initial  Aged 100° (one day)______________________________________poly(ethylene-co-maleic anhydride)M.W. 75,000-90,000           58       60   15,000-20,000           55       57    5,000-7,000 55       57    1,500-2,000.sup. 1           54       61poly(methylvinylether-co- maleic anhydride)M.W. 1,125,000  55       56    750,000     61       62    250,000     64       94poly(acrylic acid)M.W. less than 300,000           43       45   less than 150,000           47       47   less than  50,000.sup.2           50       59______________________________________ .sup.1 To demonstrate flexibility in the amount of system modifier which can be used, only one-half as much is used here as is used in the similar materials of higher molecular weight. .sup.2 To demonstrate flexibility in the amount of system modifier which can be used, twice as much is used here as is used in the similar materials of higher molecular weight. 
    
     EXAMPLE 7 
     In the same manner as described in Example 1, a system comprising 100 grams of a 10 percent aqueous solution of hydrolyzed poly(propylene-co-maleic anhydride) as the system modifier, 10 grams of urea, 1 gram of resorcinol and 200 grams of water is prepared. The pH is adjusted to 3.5 with sodium hydroxide, and 180 grams of internal phase as described in Example 1 is dispersed therein to form an emulsion in the manufacturing vehicle. Twenty-five cc. of 37 percent aqueous formaldehyde solution is added to the system. 
     Agitation of the system is continued while heating at 55° C., and after two hours the system is permitted to cool. Uniform capsules containing said internal phase material are obtained. 
     EXAMPLE 8 
     This example is identical with Example 7 except that 100 grams of a 10 percent aqueous solution of hydrolyzed poly(isobutylene-co-maleic anhydride) is used as the system modifier. Uniform capsules having strong capsule walls are again obtained utilizing the same procedure as described in Example 7. 
     EXAMPLE 9 
     This example is identical with Example 7 except that 100 grams of a 10 percent aqueous solution of hydrolyzed poly(butadiene-co-maleic anhydride) is used as the system modifier. Satisfactory capsules containing the oily dye solution are again obtained. 
     EXAMPLE 10 
     Twenty grams of dimethylol urea (DMU) is dissolved in 200 cc. of water by adding 200 cc. of boiling water to the DMU in a beaker equipped with a magnetic stirrer. The solution is cooled to about 45° C. and then about 2.7 cc. of 20 percent sodium hydroxide, 100 grams of a 10 percent aqueous solution of hydrolyzed poly(ethylene-co-maleic anhydride) and 1 gram of resorcinol are added thereto. The final pH is about 3.5. A standard internal phase as described in Example 1 in the amount of 180 grams is emulsified into the solution as the capsule core material. The system is then heated to a temperature of 55° C. in a water bath. After stirring and heating are continued for about two hours, the temperature is permitted to decrease to ambient conditions (about 25° C.). 
     The resulting capsules of oily dye solution have a uniform size range of about 1 to 15 microns and represent more than 40 percent, by volume, of the encapsulating system. 
     EXAMPLE 11 
     A solution is prepared by combining 50 grams of a 10 percent solution of poly(methyl vinyl ether-co-maleic anhydride) (Gantrez 149), 0.5 gram of resorcinol, approximately 1.4 cc. of 20 percent NaOH and 10 grams of dimethylol urea dissolved in 100 grams of hot (95° C.) water. The pH is adjusted to 3.5. Ninety grams (100 cc.) of standard internal phase as described in Example 1 (Standard IP) is emulsified into the solution, and the emulsion is placed into a water bath maintained at a temperature of 55° C. 
     After 4 hours a draw-down of this emulsion on a CF test strip gave a reflectance value of 63%. 
     The CF draw-down test is a method of determining capsule wall formation. The encapsulation emulsion containing all of the capsule-forming ingredients is coated onto a reactive CF Paper. A color is formed by the reaction of the dye with the CF coating. Wall formation is demonstrated by the mitigation of the color when the emulsion is coated at a later time and is measured by an opacimeter to give the reflectance of the coated area. 
     EXAMPLE 12 
     As described in Example 11, 20 grams of a 25% solutionof poly(acrylic acid) (Acrysol A-5), 30 grams of water, 0.5 grams of resorcinol, approximately 1.5 cc. of 20% NaOH and 10 grams of dimethylol urea dissolved in 100 grams of hot (95° C.) water are mixed. The pH is adjusted to 3.5. Ninety grams (100 cc.) of Standard IP is emulsified into the solution, and the solution is placed into a water bath maintained at a temperature of 55° C. 
     After 1 hour and 20 minutes, a sample of this emulsion coated on a CF test strip gave a reflectance value of 61%. 
     EXAMPLE 13 
     Fifty grams of a 10% solution of poly(propylene-co-maleic anhydride), 0.5 grams of resorcinol, 1.4 cc of 20% NaOH and 10 grams of dimethylol urea dissolved in 100 grams of hot (95° C.) water are mixed to form a solution. The pH is adjusted to 3.5. Ninety grams (100 cc.) of Standard IP is emulsified into the solution, and the solution is placed into a water bath maintained at a temperature of 55° C. 
     After 1 hour, a sample of this emulsion coated on a CF test strip gave a reflectance valve of 68%. 
     EXAMPLE 14 
     A 10% solution of poly(isobutylene-co-maleic anhydride) is prepared by dissolving the polymer with the aid of NaOH and then treating the resulting solution with a strongly cationic ion exchange resin (Amberlite IR 120). The pH of this solution when diluted with 2 parts of water is 3.5. 
     Fifty grams of said 10% solution of poly(isobutylene-co-maleic anhydride), 0.5 grams of resorcinol and 10 grams of dimethylol urea dissolved in 100 grams of hot (95° C.) water are mixed. Ninety grams (100 cc.) of Standard IP is emulsified into the solution, and the solution is placed into a water bath maintained at a temperature of 55° C. 
     After 1 hour, a sample of this emulsion coated on a CF test strip gave a reflectance value of 52%. A sample of this emulsion when coated on nonreactive base paper gave a reflectance of 53%. 
     EXAMPLE 15 
     A solution of 38.5 grams of a 13% solution of poly(butadiene-co-maleic anhydride) (Maldene 285, Borg-Warner Corp.) in water, 0.5 grams of resorcinol, 0.9 cc. of 20% NaOH, 11.5 grams of water and 10 grams of dimethylol urea dissolved in 100 grams of hot (95° C.) water is prepared. The pH is adjusted to 3.5. Ninety grams (100 cc.) of Standard IP is emulsified into the solution, and the solution is placed into a water bath maintained at a temperature of 55° C. 
     After 1 hour and 15 minutes, a sample of this emulsion coated on a CF test strip gave a reflectance value of 62%. 
     EXAMPLE 16 
     A solution of 400 grams of water, 200 grams of a 10% aqueous solution of poly(ethylene-co-maleic anhydride) (EMA 31), and 2 grams of resorcinol is adjusted to a pH of 3.5 with 20% NaOH. Into this solution is emulsified 400 ml. of Standard IP as described in Example 1. 
     Sample A 
     To a 484 gram portion of the above emulsion, stirring in a 55° C. water bath, is added a solution of 22.8 grams of methylated dimethylol urea resin (Beetle 60 Resin, American Cyanamid Co.) and 15.0 grams of water. 
     Sample B 
     To a 484 gram portion of the above emulsion, stirring in a 55° C. water bath, is added a solution of 20.1 grams of methylated dimethylol urea resin (Beetle 65 Resin, American Cyanamid Co.) and 17.7 grams of water. 
     Samples A and B, along with a batch prepared in accordance with Example 1 hereinabove (Sample C), are left stirring overnight in the water bath. The heat to the water bath is turned off two hours after the reactants have been added. 
     The three batch samples were tested for degree of encapsulation by coating draw-downs of the batches on CF sheets at various time intervals. The following reflectance values were obtained when the batches were tested after stirring overnight (19 hours): 
     
         ______________________________________Opacimeter Reading of Draw-Down on CF______________________________________Sample A    Sample B       Sample C______________________________________70          69             72______________________________________ 
    
     Batches of Samples A, B and C were also formulated and coated to produce CB sheets successfully. 
     Example 17 
     A solution of 100 grams of water, 50 grams of a 10% solution of poly(methyl vinyl ether-co-maleic anhydride) (Gantrez 169) and 0.5 gram of resorcinol is adjusted to a pH of 3.5 with 20% NaOH. Into this solution is emulsified 100 ml of Standard IP. 
     The emulsion is placed in a 55° C. water bath, and a solution of 10 grams of methylated dimethylol urea resin (Beetle 65) and 8.9 grams of water is added thereto. The stirring is continued for 19 hours, but the heat is turned off after 3 hours. 
     The reflectance reading of a draw-down on a CF Sheet after 19 hours was 60. 
     Example 18 
     A solution of 130 grams of water, 20 grams of a 40% solution of poly(acrylic acid) (Acrysol A-5) and 0.5 gram of resorcinol is adjusted to a pH of 3.5 with 20% NaOH. A Standard IP in the amount of 100 ml. is emulsified therein. 
     The emulsion is placed in a 55° C. water bath, and a solution of 10 grams of methylated dimethylol urea resin (Beetle 65) and 8.9 grams of water is added thereto. The stirring is continued for 19 hours, but the heat is turned off after 21/2 hours. 
     The reflectance reading of a draw-down on a CF Sheet after 19 hours was 74. 
     EXAMPLE 19 
     A solution of 50 grams of a 10% solution of poly(propylene-co-maleic anhydride), 100 grams of water, 10 grams of methylated dimethylol urea resin (Beetle 65, 100% solid), and 0.5 gram of resorcinol is adjusted to a pH of 3.5 with 20% NaOH. Ninety grams(100 ml.) of Standard IP is emulsified in the solution, and the emulsion is placed into a 55° C. water bath. 
     After 2 hours, a sample of this emulsion coated on a CF test strip gave a reflectance of 60%. A sample coated on nonreactive paper gave a reflectance of 61%. 
     EXAMPLE 20 
     A solution of 50 grams of a 10% solution of poly (isobutylene-co-maleic anhydride), 100 grams of water, 10 grams of methylated dimethylol urea resin (Beetle 65) and 0.5 gram of resorcinol is adjusted to a pH of 3.5 with NaOH. Ninety grams (100 ml.) of Standard IP is emulsified in the solution, and the emulsion is placed into a 55° C. water bath. 
     After 2 hours, a sample of this emulsion coated on a CF test strip gave a reflectance of 53%. A sample coated on nonreactive paper showed a reflectance of 54%. 
     EXAMPLE 21 
     A solution of 38.5 grams of a 13% solution of poly(butadiene-co-maleic anhydride) (Maldene 285), 101.5 grams of water, 10 grams of methylated dimethylol urea resin (Beetle 65) and 0.5 gram of resorcinol is adjusted to a pH of 3.5 with NaOH. Ninety grams (100 ml.) of Standard IP is emulsified into this solution, and the emulsion is placed into a 55° C. water bath. 
     After 2 hours and 30 minutes, a sample coated on a CF test strip gave a reflectance value of 48%. A sample coated on nonreactive paper gave a reflectance of 50%. 
     EXAMPLE 22 
     This example demonstrates that encapsulation can be obtained even with no agitation after the ingredients have been combined. 
     A solution of 100 grams of a 10% solution of poly (ethylene-co-maleic anhydride) (EMA-31), 100 grams of water, 10  grams of urea, and 1 grams of resorcinol is adjusted to a pH of 3.5 with 20% NaOH. A Standard IP (200 cc.) as described in Example 1 is emulsified into the solution, and 25 cc. of 37% formaldehyde solution is added thereto. The emulsion is placed into a 55° C. water bath without agitation. Capsules are obtained successfully without any agitation or stirring, as the batch does not set up. 
     Draw-downs on CF sheets show the formation of capsules, the opacimeter reading reaching 60 in approximately one hour. 
     EXAMPLE 23 
     A 10% solution of poly(vinyl acetate-co-maleic anhydride) is prepared by dispersing the polymer in cold water and dissolving it by the addition of 0.4 ml. of 20% NaOH per gram of dry polymer. Fifty grams of the PVAMA solution, 100 grams of water, 5 grams of urea and 0.5 grams of resorcinol are combined and adjusted to a pH of about 3.6 with NaOH. Ninety grams (100 ml.) of Standard IP is emulsified into the solution, and 12.5 ml. of 37% aqueous formaldehyde solution is added thereto. The emulsion is placed into a 55° C. water bath. The heat is turned off after 4 hours, and the emulsion is left in the water bath overnight. 
     A sample of the resulting emulsion coated on a CF test strip gave an opacimeter reading of 56%. A sample of the emulsion coated on nonreactive paper gave an opacimeter reading of 65%. 
     The amounts and kinds of encapsulating system materials used in these examples are any of those previously disclosed. The pH of the encapsulating system can be pH 0-7 and the formaldehyde to urea mole ratio can be from 1.6 to 3. As the pH of the system is increased, it is helpful to increase the temperature of the encapsulating system also. Eligible temperatures of operation range from about 25° to 100° under ambient conditions, about 50°-55° being preferred. 
     By adjusting the degree of agitation, if employed, droplets of liquid intended capsule core material can be produced of any size from a few to several hundred microns. Moreover, the amount of intended capsule core material can be altered to change the amount of completed capsule which is internal phase as opposed to capsule wall material. Capsules can generally be made from less than 50 percent internal phase to 95 percent internal phase, or more. 
     The amount of system modifier in the encapsulating system appears to be important to the practice of this invention, with respect to the minimum amount to assure adequate interference with the condensation reaction to form polymer and with respect to the maximum amount as an economic matter. Of course, if the system modifier is present in very high concentrations, the system viscosity will be inoperably high. As a general rule, the encapsulating system should include at least about 0.75 percent system modifier. At the other extreme, it must be remembered that the variety of eligible materials precludes establishment of an exact general maximum due to differences in solution viscosity among the several materials. It can be said that more than 10 percent is seldom used or required. However, amount of system modifier of up to about 15 percent can be employed, if desired. 
     It may be generally stated that the amount of system modifier material employed is that amount sufficient to modify the polymerization of the urea with formaldehyde, in one embodiment, or the polymerization of the dimethylol urea or methylated dimethylol urea, in another embodiment of the invention, so as to permit formation of polymeric capsular walls therefrom. 
     The invention being thus described, it will be obvious that the same may be varied in many ways. Such variations are not to be regarded as a departure from the spirit and scope of the invention, and all such modifications are intended to be included within the scope of the following claims.