Abstract:
IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.

Description:
This application claims benefit to International Application No. PCT/US2008/063621, filed May 15, 2008, under 35 U.S.C. §365(a); which claims priority to provisional application U.S. Serial No. 60/938,570, filed May 17, 2007; under 35 U.S.C. §119(e). The entire teachings of the referenced applications are incorporated herein by reference. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates generally to the field of pharmacogenomics, and more specifically, to methods and procedures used to monitor response or determine sensitivity in patients to allow the identification of individualized genetic profiles which will aid in treating diseases and disorders. 
     BRIEF DESCRIPTION OF THE SEQUENCE LISTING 
     Incorporated herein by reference in its entirety is a Sequence Listing entitled, “11082USPCT ST25.txt”, comprising SEQ ID NO:1 through SEQ ID NO:286, which include amino acid sequences disclosed herein. The Sequence Listing has been submitted herewith in ASCII text format via EFS, and thus constitutes both the paper and computer readable form thereof. The Sequence Listing was first created using PatentIn on May 7, 2012, and is 52 KB in size. 
     BACKGROUND OF THE INVENTION 
     Cancer is a disease with extensive histoclinical heterogeneity. Although conventional histological and clinical features have been correlated to prognosis, the same apparent prognostic type of tumors varies widely in its responsiveness to therapy and consequent survival of the patient. 
     New prognostic and predictive markers, which would facilitate an individualization of therapy for each patient, are needed to accurately predict patient response to treatments, such as small molecule or biological molecule drugs, in the clinic. The problem may be solved by the identification of new parameters that could better predict the patient&#39;s sensitivity to treatment. The classification of patient samples is a crucial aspect of cancer diagnosis and treatment. The association of a patient&#39;s response to a treatment with molecular and genetic markers can open up new opportunities for treatment development in non-responding patients, or distinguish a treatment&#39;s indication among other treatment choices because of higher confidence in the efficacy. Further, the pre-selection of patients who are likely to respond well to a medicine, drug, or combination therapy may reduce the number of patients needed in a clinical study or accelerate the time needed to complete a clinical development program (M. Cockett et al., Current Opinion in Biotechnology, 11:602-609 (2000)). 
     The ability to determine which patients are responding to anti-angiogenesis therapies (such as IGF1R modulators) or predict drug sensitivity in patients is particularly challenging because drug responses reflect not only properties intrinsic to the target cells, but also a host&#39;s metabolic properties. Efforts to use genetic information to predict or monitor drug response have primarily focused on individual genes that have broad effects, such as the multidrug resistance genes mdr1 and mrp1 (P. Sonneveld, J. Intern. Med., 247:521-534 (2000)). 
     The development of microarray technologies for large scale characterization of gene mRNA expression pattern has made it possible to systematically search for molecular markers and to categorize cancers into distinct subgroups not evident by traditional histopathological methods (J. Khan et al., Cancer Res., 58:5009-5013 (1998); A. A. Alizadeh et al., Nature, 403:503-511 (2000); M. Bittner et al., Nature, 406:536-540 (2000); J. Khan et al., Nature Medicine, 7(6):673-679 (2001); and T. R. Golub et al., Science, 286:531-537 (1999); U. Alon et al., P.N.A.S. USA, 96:6745-6750 (1999)). Such technologies and molecular tools have made it possible to monitor the expression level of a large number of transcripts within a cell population at any given time (see, e.g., Schena et al., Science, 270:467-470 (1995); Lockhart et al., Nature Biotechnology, 14:1675-1680 (1996); Blanchard et al., Nature Biotechnology, 14:1649 (1996); U.S. Pat. No. 5,569,588 to Ashby et al.). 
     Recent studies demonstrate that gene expression information generated by microarray analysis of human tumors can predict clinical outcome (L. J. van&#39;t Veer et al., Nature, 415:530-536 (2002); M. Shipp et al., Nature Medicine, 8(1):68-74 (2002); G. Glinsky et al., The Journal of Clin. Invest., 113(6):913-923 (2004)). These findings bring hope that cancer treatment will be vastly improved by better predicting and monitoring the response of individual tumors to therapy. 
     PCT Application No. PCT/US2006/034201 provides biomarkers useful for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator. 
     Needed are new and alternative methods and procedures to determine drug sensitivity or monitor response in patients to allow the development of individualized diagnostics which are necessary to treat diseases and disorders based on patient response at a molecular level. 
     SUMMARY OF THE INVENTION 
     The invention provides methods and procedures for determining patient sensitivity or monitor response at the molecular level to one or more insulin growth factor 1 receptor (IGF1R) modulators. The invention also provides methods of determining or predicting whether an individual requiring therapy for a disease state such as cancer will or will not respond to treatment, prior to administration of the treatment, wherein the treatment comprises administration of one or more IGF1R modulators. The one or more IGF1R modulators are compounds that can be selected from, for example, one or more IGF1R specific ligands, one or more small molecule IGF1R inhibitors, or one or more IGF1R binding monoclonal antibodies. 
     In one aspect, the invention provides a method for predicting the likelihood a mammal will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8; (b) exposing a biological sample from said mammal to the IGF1R modulator; (c) following the exposing of step (b), measuring in said biological sample the level of the at least one biomarker, wherein an increase in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a), indicates an increased likelihood that the mammal will respond therapeutically to said method of treating cancer when said at least one biomarker is a sensitivity biomarker, and indicates an increased likelihood that the mammal will not respond therapeutically to said method of treating cancer when said at least one biomarker is a resistance biomarker. 
     In another aspect, the invention provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8; (b) exposing a biological sample from the mammal to the IGF1R modulator; (c) following the exposing in step (b), measuring in said biological sample the level of the at least one biomarker and using said measurement to determine whether the mammal is likely to respond therapeutically to said method of treating cancer. 
     A difference in the level of the biomarker that is sufficient to indicate whether the mammal will or will not respond therapeutically to the method of treating cancer can be readily determined by one of skill in the art using known techniques. The increase or decrease in the level of the biomarker can be correlated to determine whether the difference is sufficient to identify a mammal that will respond therapeutically. The difference in the level of the biomarker that is sufficient can, in one aspect, be predetermined prior to determining whether the mammal will respond therapeutically to the treatment. In one aspect, the difference in the level of the biomarker is a difference in the mRNA level (measured, for example, by RT-PCR or a microarray), such as at least a two-fold difference, at least a three-fold difference, or at least a four-fold difference in the level of expression. In another aspect, the difference in the level of the biomarker is determined by IHC. In another aspect, the difference in the level of the biomarker refers to a p-value of &lt;0.05 in Anova analysis. In yet another aspect, the difference is determined in an ELISA assay. 
     As used herein, respond therapeutically refers to the alleviation or abrogation of the cancer. This means that the life expectancy of an individual affected with the cancer will be increased or that one or more of the symptoms of the cancer will be reduced or ameliorated. The term encompasses a reduction in cancerous cell growth or tumor volume. Whether a mammal responds therapeutically can be measured by many methods well known in the art, such as PET imaging. 
     The mammal can be, for example, a human, rat, mouse, dog rabbit, pig sheep, cow, horse, cat, primate, or monkey. 
     The method of the invention can be, for example, an in vitro method wherein the step of measuring in the mammal the level of at least one biomarker comprises taking a biological sample from the mammal and then measuring the level of the biomarker(s) in the biological sample. The biological sample can comprise, for example, at least one of serum, whole fresh blood, peripheral blood mononuclear cells, frozen whole blood, fresh plasma, frozen plasma, urine, saliva, skin, hair follicle, bone marrow, or tumor tissue. 
     The level of the at least one biomarker can be, for example, the level of protein and/or mRNA transcript of the biomarker(s). 
     In another aspect, the invention provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises: (a) exposing a biological sample from the mammal to the IGF1R modulator; (b) following the exposing of step (a), measuring in said biological sample the level of at least one biomarker selected from the biomarkers of Tables 2-8, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said IGF1R modulator, indicates that the mammal will respond therapeutically to said method of treating cancer. 
     In yet another aspect, the invention provides a method for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8; (b) exposing the mammal to the IGF1R modulator; (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer. 
     In another aspect, the invention provides a method for determining whether a compound inhibits IGF1R activity in a mammal, comprising: (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said compound, indicates that the compound inhibits IGF1R activity in the mammal 
     In yet another aspect, the invention provides a method for determining whether a mammal has been exposed to a compound that inhibits IGF1R activity, comprising (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said compound, indicates that the mammal has been exposed to a compound that inhibits IGF1R activity. 
     In another aspect, the invention provides a method for determining whether a mammal is responding to a compound that inhibits IGF1R activity, comprising (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the at least one biomarker in a mammal that has not been exposed to said compound, indicates that the mammal is responding to the compound that inhibits IGF1R activity. 
     As used herein, “responding” encompasses responding by way of a biological and cellular response, as well as a clinical response (such as improved symptoms, a therapeutic effect, or an adverse event), in a mammal 
     The invention also provides an isolated biomarker selected from the biomarkers of Tables 2-8. The biomarkers of the invention comprise sequences selected from the nucleotide and amino acid sequences provided in Tables 2-8 and the Sequence Listing, as well as fragments and variants thereof. 
     The invention also provides a biomarker set comprising two or more biomarkers selected from the biomarkers of Tables 2-8. 
     The invention also provides kits for determining or predicting whether a patient would be susceptible or resistant to a treatment that comprises one or more IGF1R modulators. The patient may have a cancer or tumor such as, for example, a colon cancer or tumor. 
     In one aspect, the kit comprises a suitable container that comprises one or more specialized microarrays of the invention, one or more IGF1R modulators for use in testing cells from patient tissue specimens or patient samples, and instructions for use. The kit may further comprise reagents or materials for monitoring the expression of a biomarker set at the level of mRNA or protein. 
     In another aspect, the invention provides a kit comprising two or more biomarkers selected from the biomarkers of Tables 2-8. 
     In yet another aspect, the invention provides a kit comprising at least one of an antibody and a nucleic acid for detecting the presence of at least one of the biomarkers selected from the biomarkers of Tables 2-8. In one aspect, the kit further comprises instructions for determining whether or not a mammal will respond therapeutically to a method of treating cancer comprising administering a compound that inhibits IGF1R activity. In another aspect, the instructions comprise the steps of (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Tables 2-8, (b) exposing the mammal to the compound, (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer. 
     The invention also provides screening assays for determining if a patient will be susceptible or resistant to treatment with one or more IGF1R modulators. 
     The invention also provides a method of monitoring the treatment of a patient having a disease, wherein said disease is treated by a method comprising administering one or more IGF1R modulators. 
     The invention also provides individualized genetic profiles which are necessary to treat diseases and disorders based on patient response at a molecular level. 
     The invention also provides specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers having expression profiles that correlate with either sensitivity or resistance to one or more IGF1R modulators. 
     The invention also provides antibodies, including polyclonal or monoclonal, directed against one or more biomarkers of the invention. 
     The invention will be better understood upon a reading of the detailed description of the invention when considered in connection with any accompanying figures. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Identification of biomarkers that provide rapid and accessible readouts of efficacy, drug exposure, or clinical response is increasingly important in the clinical development of drug candidates. Embodiments of the invention include measuring changes in the levels of secreted proteins, or plasma biomarkers, which represent one category of biomarker. In one aspect, plasma samples, which represent a readily accessible source of material, serve as surrogate tissue for biomarker analysis. 
     The invention provides biomarkers that respond to the modulation of a specific signal transduction pathway and also correlate with IGF1R modulator sensitivity or resistance. These biomarkers can be employed for predicting and monitoring response to one or more IGF1R modulators. In one aspect, the biomarkers of the invention are those provided in Tables 2-8 and the Sequence Listing, including both polynucleotide and polypeptide sequences. In another aspect, the biomarkers of the invention are nucleotide sequences that, due to the degeneracy of the genetic code, encodes for a polypeptide sequence provided in the sequence listing. 
     The biomarkers serve as useful molecular tools for predicting and monitoring response to IGF1R modulators that affect IGF1R activity or the IGF1R signal transduction pathway. 
     In addition to playing an important role in normal cell growth, maintenance and development, insulin-like growth factor receptor (IGF1R) and its ligands are also important in the establishment and maintenance of the malignant phenotype. Binding of IGF-1 and IGF-II ligands to the IGF1R initiates a cascade of events leading to activation of mitogenic signaling pathway (Ras/Raf/MAPK) and antiapoptotic/survival pathway (PI3K-Akt/mTor), resulting in proliferation, transformation and survival in tumor cells (D. LeRoith, et al., Cancer Lett., 195(2):127-37 (2003), R. Baserga, et al., Int. J. Cancer;107:873-7 (2003)). IGF1R overexpression and/or enhanced activity have been observed in diverse tumor types suggesting that the potential therapeutic use of agents targeting this pathway is broad. IGF1R provides a critical survival signal in multiple tumor types. The expression of this receptor is an indicator of poor prognosis, thus, it has emerged as an attractive and compelling target for cancer therapy to inhibit the progression of multiple tumor types in cancer patients. Various drug discovery approaches have been explored in recent years to modulate the function of IGF1R. Approaches aimed at the reduction of receptor number or enzymatic activity using a variety of strategies in preclinical models have been shown to reverse the malignant phenotype in tumor cells. These strategies include antisense (L. Long, et al., Cancer Res, 55(5):1006-9 (1995), D. Andrews et al., J. Clin. Oncol., 19(8):2189-200 (2001)), monoclonal antibody (C. Arteaga, et al., Cancer Res., 49(22):6237-41 (1989)), small molecule inhibitors (M. Wittman, et al., J. Med. Chem., September 8;48(18):5639-43 (2005), C. Garcia-Echeverria, et al., Cancer Cell, 5(3):231-9 (2004)), IGF-1 mimetic peptides (Z. Pietrzkowski, et al., Cancer Res., 53(5):1102-6 (1993)) as well as dominant negative mutants that lack enzyme activity (C. D&#39;Ambrosio, et al., Cancer Res, 56(17): 4013-20 (1996)). 
     However, this targeted therapy may only be successful if the receptor is absolutely necessary for pathogenesis and tumor progression. IGF1R and its ligands have been shown to be important in the mesenchymal originated soft tissue sarcomas and neuroblastoma (G. Merlino, et al., Oncogene;18:5340-8 (1999), K. Scotlandi, et al., Cancer Res.;56:4570-4 (1996), S. Burrow, et al., J. Surg. Oncol.;69:21-7 (1998), D. Yee, et al., J. Clin. Invest., 86(6) : 1806-14 (1990)). These rare tumors have distinctive biological characteristics including aggressive local behavior and a predilection for metastasis. With multimodal treatments and very aggressive chemotherapeutic regimens, the survival rate is disappointingly low and, thus, there is a high unmet medical need for the treatment of patients with these tumor types. Inhibition of IGF1R by antibody or small molecule either alone or in combination with other chemotherapeutic agents have demonstrated antitumor activity in sarcomas (S. Benini, et al., Clinical Cancer Res., 7, 1790-97 (2001), K. Scotlandi, et al., Cancer Res., May 1;65(9):3868-76 (2005), M. Manara, et al., Clinical Cancer Res.; 13(4) 1322-30 (2007)). 
     One of the integral goals in the development of these targeted cancer therapies is to identify the targeted patients population who are most likely to benefit from the drug treatment. Utilizing biomarkers has successfully guided the development of Herceptin® and EGFR inhibitors (J. Baselga, et al., J Clin Oncol. 14, 737-744 (2005), T. Lynch, et al., N. Engl. J. Med., 350, 2129-2139 (2004)). More recently, gene expression profiling studies have demonstrated the advantages of molecular “signatures” or marker sets generated by microarray analysis in predicting chemotherapeutic response and guiding the targeted therapies (K. Iwao-Koizumi, et al., J. Clin. Oncol.;23:422-31 (2005), H. Dressman, et al., Clin. Cancer Res.;12:819-26 (2006), R. Rouzier, et al., Clin. Cancer Res.;11:5678-85 (2005), K. Hess, et al., J. Clin. Oncol.;24:4236-44 (2006), H. Dressman, et al., J. Clin. Oncol., February 10;25(5):517-25 (2007), A. Potti, et al., Nat. Med., November;12(11):1294-300 (2006)). These findings provide hope that cancer treatments of the future will be vastly improved by using molecular “signatures” to choose the most effective drug for patient targeting. One of the challenges is to determine the targeted patient population for the drug before clinical data is available. 
     To overcome this challenge, as described previously (F. Huang F, et al., Cancer Res., March 1;67(5):2226-38 (2007)), cultured cancer cell lines can be used as models to identify biomarkers that correlate with response to a therapy assuming these markers identified in vitro are ultimately applicable in clinical studies to select targeted patient population. 
     To this end, in this study, the gene and protein profiling by both microarray and LC/MS based “bottom-up” protein profiling (M. Lipton, et al., Proc. Natl. Acad. Sci. USA., August 20;99(17):11049-54 (2002), H. Prokisch et al., PLoS Biol., June;2(6):e160 (2004)) were conduced in parallel using a panel of 29 cell lines to identify genes or proteins whose basal expression levels are correlated with the in vitro sensitivity of cells to compound 1 or compound 2 (as defined below) and potentially could be used as predictive markers. To gain insights of acquired resistance of compound 1, gene expression profiles of a pair of sensitive and acquired resistant cell lines were compared to identify genes correlated with the acquired resistance. These genes were then compared to the genes over expressed in the resistant cell lines at basal level (correlated with the de novo resistance to the drug). Common mechanism of de novo resistance and acquired resistance to IGF1R inhibitor compound 1 was explored. Furthermore, genes/proteins modulated by drug treatment of compound 1 were identified and linked to the possible mechanisms of the drug action. These markers could be useful to monitor the biological effects of the drug and to select the optimal dose in the clinical studies. To explore the relation between these biomarkers and the drug target IGF1R, pathway analyses were performed and cross-talk between the IGF1R and other kinases was evident, this led us to propose the hypothesis for the potential synergistic activity between compound 1 and other agents targeting these kinases. Drug combination studies of compound 1 with other agents, such as EGFR inhibitors, were performed and synergy in tumor growth inhibition in vitro was observed with combined inhibition of multiple pathways. In this study, we identified the biomarkers of potentially predictive the targeted sub-population of patient with sarcomas that would be benefit from the treatment of IGF1R inhibitor. 
     IGF1R Modulators: 
     As used herein, the term “IGF1R modulator” is intended to mean a compound or drug that is a biological molecule or a small molecule that directly or indirectly modulates IGF1R activity or the IGF1R signal transduction pathway. Thus, compounds or drugs as used herein is intended to include both small molecules and biological molecules. Direct or indirect modulation includes activation or inhibition of IGF1R activity or the IGF1R signal transduction pathway. In one aspect, inhibition refers to inhibition of the binding of IGF1R to an IGF1R ligand such as, for example, VEGF. In another aspect, inhibition refers to inhibition of the kinase activity of IGF1R. 
     IGF1R modulators include, for example, IGF1R specific ligands, small molecule IGF1R inhibitors, and IGF1R monoclonal antibodies. In one aspect, the IGF1R modulator inhibits IGF1R activity and/or inhibits the IGF1R signal transduction pathway. In another aspect, the IGF1R modulator is an IGF1R monoclonal antibody that inhibits IGF1R activity and/or inhibits the IGF1R signal transduction pathway. 
     IGF1R modulators include biological molecules or small molecules. 
     Biological molecules include all lipids and polymers of monosaccharides, amino acids, and nucleotides having a molecular weight greater than 450. Thus, biological molecules include, for example, oligosaccharides and polysaccharides; oligopeptides, polypeptides, peptides, and proteins; and oligonucleotides and polynucleotides. Oligonucleotides and polynucleotides include, for example, DNA and RNA. 
     Biological molecules further include derivatives of any of the molecules described above. For example, derivatives of biological molecules include lipid and glycosylation derivatives of oligopeptides, polypeptides, peptides, and proteins. 
     Derivatives of biological molecules further include lipid derivatives of oligosaccharides and polysaccharides, e.g., lipopolysaccharides. Most typically, biological molecules are antibodies, or functional equivalents of antibodies. Functional equivalents of antibodies have binding characteristics comparable to those of antibodies, and inhibit the growth of cells that express IGF1R. Such functional equivalents include, for example, chimerized, humanized, and single chain antibodies as well as fragments thereof 
     Functional equivalents of antibodies also include polypeptides with amino acid sequences substantially the same as the amino acid sequence of the variable or hypervariable regions of the antibodies. An amino acid sequence that is substantially the same as another sequence, but that differs from the other sequence by means of one or more substitutions, additions, and/or deletions, is considered to be an equivalent sequence. Preferably, less than 50%, more preferably less than 25%, and still more preferably less than 10%, of the number of amino acid residues in a sequence are substituted for, added to, or deleted from the protein. 
     The functional equivalent of an antibody is preferably a chimerized or humanized antibody. A chimerized antibody comprises the variable region of a non-human antibody and the constant region of a human antibody. A humanized antibody comprises the hypervariable region (CDRs) of a non-human antibody. The variable region other than the hypervariable region, e.g., the framework variable region, and the constant region of a humanized antibody are those of a human antibody. 
     Suitable variable and hypervariable regions of non-human antibodies may be derived from antibodies produced by any non-human mammal in which monoclonal antibodies are made. Suitable examples of mammals other than humans include, for example, rabbits, rats, mice, horses, goats, or primates. 
     Functional equivalents further include fragments of antibodies that have binding characteristics that are the same as, or are comparable to, those of the whole antibody. Suitable fragments of the antibody include any fragment that comprises a sufficient portion of the hypervariable (i.e., complementarity determining) region to bind specifically, and with sufficient affinity, to IGF1R tyrosine kinase to inhibit growth of cells that express such receptors. 
     Such fragments may, for example, contain one or both Fab fragments or the F(ab′)2 fragment. Preferably, the antibody fragments contain all six complementarity determining regions of the whole antibody, although functional fragments containing fewer than all of such regions, such as three, four, or five CDRs, are also included. 
     In one aspect, the fragments are single chain antibodies, or Fv fragments. Single chain antibodies are polypeptides that comprise at least the variable region of the heavy chain of the antibody linked to the variable region of the light chain, with or without an interconnecting linker. Thus, Fv fragment comprises the entire antibody combining site. These chains may be produced in bacteria or in eukaryotic cells. 
     The antibodies and functional equivalents may be members of any class of immunoglobulins, such as IgG, IgM, IgA, IgD, or IgE, and the subclasses thereof. 
     In one aspect, the antibodies are members of the IgG1 subclass. The functional equivalents may also be equivalents of combinations of any of the above classes and subclasses. 
     In one aspect, the IGF1R antibody is provided in PCT publication nos. WO2005/016970, WO02/53596, WO2004/71529, WO2005/16967, WO2004/83248, WO03/106621, WO03/100008, WO03/59951, WO2004/87756, or WO2005/05635. 
     In another aspect, the IGF1R modulator is derived from fibronectin, such as an AdNectin (Adnexus Therapeutics) (See, PCT publication nos. WO00/34784, WO01/64942, WO02/32925). 
     In addition to the biological molecules discussed above, the IGF1R modulators useful in the invention may also be small molecules. Any molecule that is not a biological molecule is considered herein to be a small molecule. Some examples of small molecules include organic compounds, organometallic compounds, salts of organic and organometallic compounds, saccharides, amino acids, and nucleotides. Small molecules further include molecules that would otherwise be considered biological molecules, except their molecular weight is not greater than 450. Thus, small molecules may be lipids, oligosaccharides, oligopeptides, and oligonucleotides and their derivatives, having a molecular weight of 450 or less. 
     It is emphasized that small molecules can have any molecular weight. They are merely called small molecules because they typically have molecular weights less than 450. Small molecules include compounds that are found in nature as well as synthetic compounds. In one embodiment, the IGF1R modulator is a small molecule that inhibits the growth of tumor cells that express IGF1R. In another embodiment, the IGF1R modulator is a small molecule that inhibits the growth of refractory tumor cells that express IGF1R. 
     Numerous small molecules have been described as being useful to inhibit IGF1R. 
     In one aspect, the IGF1R modulator is selected from PCT publication nos. WO02/79192, WO2004/30620, WO2004/31401 WO2004/63151, and WO2005/21510, and from U.S. provisional application Nos. 60/819,171, 60/870,872, 60/883,601, and 60/912,446. 
     In another aspect, the IGF1R modulator is selected from (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)-pyridin-2(1-H)-one and (2S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide. 
     In another aspect, the IGF1R modulator is selected from XL-228 (Exelixis), AEW-541 (Novartis), and OSI-906 (OSI). 
     Biomarkers and Biomarker Sets: 
     The invention includes individual biomarkers and biomarker sets having both diagnostic and prognostic value in disease areas in which signaling through IGF1R or the IGF1R pathway is of importance, e.g., in cancers or tumors, in immunological disorders, conditions or dysfunctions, or in disease states in which cell signaling and/or cellular proliferation controls are abnormal or aberrant. The biomarker sets comprise a plurality of biomarkers such as, for example, a plurality of the biomarkers provided in Tables 2-8 that highly correlate with resistance or sensitivity to one or more IGF1R modulators. 
     The biomarkers and biomarker sets of the invention enable one to predict or reasonably foretell the likely effect of one or more IGF1R modulators in different biological systems or for cellular responses. The biomarkers and biomarker sets can be used in in vitro assays of IGF1R modulator response by test cells to predict in vivo outcome. In accordance with the invention, the various biomarkers and biomarker sets described herein, or the combination of these biomarker sets with other biomarkers or markers, can be used, for example, to predict and monitor how patients with cancer might respond to therapeutic intervention with one or more IGF1R modulators. 
     A biomarker and biomarker set of cellular gene expression patterns correlating with sensitivity or resistance of cells following exposure of the cells to one or more IGF1R modulators provides a useful tool for screening one or more tumor samples before treatment with the IGF1R modulator. The screening allows a prediction of cells of a tumor sample exposed to one or more IGF1R modulators, based on the expression results of the biomarker and biomarker set, as to whether or not the tumor, and hence a patient harboring the tumor, will or will not respond to treatment with the IGF1R modulator. 
     The biomarker or biomarker set can also be used as described herein for monitoring the progress of disease treatment or therapy in those patients undergoing treatment for a disease involving an IGF1R modulator. 
     The biomarkers also serve as targets for the development of therapies for disease treatment. Such targets may be particularly applicable to treatment of cancer, such as, for example, hepatocellular carcinoma, colorectal cancer (CRC), NSCLC, and metastatic breast cancer. 
     Indeed, because these biomarkers are differentially expressed in sensitive and resistant cells, their expression patterns are correlated with relative intrinsic sensitivity of cells to treatment with IGF1R modulators. Accordingly, the biomarkers highly expressed in resistant cells may serve as targets for the development of new therapies for the tumors which are resistant to IGF1R modulators, particularly IGF1R inhibitors. The level of biomarker protein and/or mRNA can be determined using methods well known to those skilled in the art. For example, quantification of protein can be carried out using methods such as ELISA, 2-dimensional SDS PAGE, Western blot, immunopreciptation, immunohistochemistry, fluorescence activated cell sorting (FACS), or flow cytometry. Quantification of mRNA can be carried out using methods such as PCR, array hybridization, Northern blot, in-situ hybridization, dot-blot, Taqman, or RNAse protection assay. 
     Microassays: 
     The invention also includes specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers, showing expression profiles that correlate with either sensitivity or resistance to one or more IGF1R modulators. Such microarrays can be employed in in vitro assays for assessing the expression level of the biomarkers in the test cells from tumor biopsies, and determining whether these test cells are likely to be resistant or sensitive to IGF1R modulators. For example, a specialized microarray can be prepared using all the biomarkers, or subsets thereof, as described herein and shown in Tables 2-8. Cells from a tissue or organ biopsy can be isolated and exposed to one or more of the IGF1R modulators. In one aspect, following application of nucleic acids isolated from both untreated and treated cells to one or more of the specialized microarrays, the pattern of gene expression of the tested cells can be determined and compared with that of the biomarker pattern from the control panel of cells used to create the biomarker set on the microarray. Based upon the gene expression pattern results from the cells that underwent testing, it can be determined if the cells show a resistant or a sensitive profile of gene expression. Whether or not the tested cells from a tissue or organ biopsy will respond to one or more of the IGF1R modulators and the course of treatment or therapy can then be determined or evaluated based on the information gleaned from the results of the specialized microarray analysis. 
     Antibodies: 
     The invention also includes antibodies, including polyclonal or monoclonal, directed against one or more of the polypeptide biomarkers. Such antibodies can be used in a variety of ways, for example, to purify, detect, and target the biomarkers of the invention, including both in vitro and in vivo diagnostic, detection, screening, and/or therapeutic methods. 
     Kits: 
     The invention also includes kits for determining or predicting whether a patient would be susceptible or resistant to a treatment that comprises one or more IGF1R modulators. The patient may have a cancer or tumor such as, for example, a breast cancer or tumor. Such kits would be useful in a clinical setting for use in testing a patient&#39;s biopsied tumor or cancer samples, for example, to determine or predict if the patient&#39;s tumor or cancer will be resistant or sensitive to a given treatment or therapy with an IGF1R modulator. The kit comprises a suitable container that comprises: one or more microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, that comprise those biomarkers that correlate with resistance and sensitivity to IGF1R modulators, particularly IGF1R inhibitors; one or more IGF1R modulators for use in testing cells from patient tissue specimens or patient samples; and instructions for use. In addition, kits contemplated by the invention can further include, for example, reagents or materials for monitoring the expression of biomarkers of the invention at the level of mRNA or protein, using other techniques and systems practiced in the art such as, for example, RT-PCR assays, which employ primers designed on the basis of one or more of the biomarkers described herein, immunoassays, such as enzyme linked immunosorbent assays (ELISAs), immunoblotting, e.g., Western blots, or in situ hybridization, and the like, as further described herein. 
     Application of Biomarkers and Biomarker Sets: 
     The biomarkers and biomarker sets may be used in different applications. Biomarker sets can be built from any combination of biomarkers listed in Tables 2-8 to make predictions about the likely effect of any IGF1R modulator in different biological systems. The various biomarkers and biomarkers sets described herein can be used, for example, as diagnostic or prognostic indicators in disease management, to predict how patients with cancer might respond to therapeutic intervention with compounds that modulate the IGF1R, and to predict how patients might respond to therapeutic intervention that modulates signaling through the entire IGF1R regulatory pathway. 
     While the data described herein were generated in cell lines that are routinely used to screen and identify compounds that have potential utility for cancer therapy, the biomarkers have both diagnostic and prognostic value in other diseases areas in which signaling through IGF1R or the IGF1R pathway is of importance, e.g., in immunology, or in cancers or tumors in which cell signaling and/or proliferation controls have gone awry. 
     In accordance with the invention, cells from a patient tissue sample, e.g., a tumor or cancer biopsy, can be assayed to determine the expression pattern of one or more biomarkers prior to treatment with one or more IGF1R modulators. Success or failure of a treatment can be determined based on the biomarker expression pattern of the cells from the test tissue (test cells), e.g., tumor or cancer biopsy, as being relatively similar or different from the expression pattern of a control set of the one or more biomarkers. Thus, if the test cells show a biomarker expression profile which corresponds to that of the biomarkers in the control panel of cells which are sensitive to the IGF1R modulator, it is highly likely or predicted that the individual&#39;s cancer or tumor will respond favorably to treatment with the IGF1R modulator. By contrast, if the test cells show a biomarker expression pattern corresponding to that of the biomarkers of the control panel of cells which are resistant to the IGF1R modulator, it is highly likely or predicted that the individual&#39;s cancer or tumor will not respond to treatment with the IGF1R modulator. 
     The invention also provides a method of monitoring the treatment of a patient having a disease treatable by one or more IGF1R modulators. The isolated test cells from the patient&#39;s tissue sample, e.g., a tumor biopsy or blood sample, can be assayed to determine the expression pattern of one or more biomarkers before and after exposure to an IGF1R modulator wherein, preferably, the IGF1R modulator is an IGF1R inhibitor. The resulting biomarker expression profile of the test cells before and after treatment is compared with that of one or more biomarkers as described and shown herein to be highly expressed in the control panel of cells that are either resistant or sensitive to an IGF1R modulator. Thus, if a patient&#39;s response is sensitive to treatment by an IGF1R modulator, based on correlation of the expression profile of the one or biomarkers, the patient&#39;s treatment prognosis can be qualified as favorable and treatment can continue. Also, if, after treatment with an IGF1R modulator, the test cells don&#39;t show a change in the biomarker expression profile corresponding to the control panel of cells that are sensitive to the IGF1R modulator, it can serve as an indicator that the current treatment should be modified, changed, or even discontinued. This monitoring process can indicate success or failure of a patient&#39;s treatment with an IGF1R modulator and such monitoring processes can be repeated as necessary or desired. 
     The biomarkers of the invention can be used to predict an outcome prior to having any knowledge about a biological system. Essentially, a biomarker can be considered to be a statistical tool. Biomarkers are useful primarily in predicting the phenotype that is used to classify the biological system. In an embodiment of the invention, the goal of the prediction is to classify cancer cells as having an active or inactive IGF1R pathway. Cancer cells with an inactive IGF1R pathway can be considered resistant to treatment with an IGF1R modulator. 
     EXAMPLES 
     Methods and Samples: 
     In the following examples, the compound (S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)-pyridin-2(1-H)-one was used: 
                                
This compound is referred to herein as “compound 1.”
 
     In the following examples, the compound (2S)-1-(4-((5-cyclopropy1-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide was used: 
     
       
                 
         
             
             
         
      
     
     This compound is referred to herein as “compound 2.” 
     Example 1 
     Identification of Biomarkers 
     Methods and Materials 
     Cell Lines: 
     All pediatric sarcoma and neuroblastoma cell lines were obtained from Dr. Lee Helman at NIH. All cell lines were grown in RPMI medium supplemented with Glutamax (Gibco/Invitrogen #61870-036), 10% inactivated fetal bovine serum (Gibco/Invitrogen #16140-071), 10 mM Hepes, penicillin and streptomycin. For the baseline profiling study, cells were harvested at 70-80% confluence; and for drug treatment study, two rhabdomyosarcoma (RMS) cell lines Rh36 and Rh41 were treated with 0.35 μM compound 1 for 6, 36 and 72 hours before harvest. To develop the compound 1-resistant RD1, the sensitive RD-1 cells (IC 50 =0.238 μM to compound 1) were first exposed to the dug at the IC 50  concentration and passed as the cultures reached 70-80% confluence. The concentration of compound 1 was increased gradually every other culture passage and the IC 50  value for the compound in these cells was measured periodically during this treatment time until the resistance level reached a plateau. The resulted RD1-Resist cells has IC 50 =1.999 μM to compound 1, more than 8 fold of the parental RD1. 
     In vitro Cellular Proliferation Assays: 
     Proliferation was evaluated by incorporation of [3H]-thymidine into DNA after exposure to IGF1R inhibitor compound 1 or compound 2 to determine the sensitivity of cell lines to these compounds. Cells were plated at an optimized density for each cell line per well in 96-well microtiter Falcon plates, incubated overnight, and then exposed to a serial dilution of drug. After 72 hours incubation with drug at 37° C., cells were pulsed with 4 μCi/ml [6-3H] thymidine (Amersham Pharmacia Biotech, UK) for 3 hours, trypsinized, harvested onto UniFilter-96, GF/B plates (PerkinElmer, Boston, Mass.) and scintillation was measured on a TopCount NXT (Packard, Conn.). Results were expressed as an IC 50 , which is the drug concentration required to inhibit cell proliferation by 50% to that of untreated control cells. The mean IC 50  and standard deviation (SD) from multiple tests for each cell line were calculated. 
     Drug Combination Study: 
     A Dilution of Ratios Drug Combination method was used in cellular proliferation assays to determine whether there was synergy, additivity or antagonism when two compounds were added simultaneously to a variety of human tumor cells in vitro (R. Tallarida, R. J., Drug Synergism and Dose-Effect Data Analysis. 1st edition ed. Chapman &amp; Hall/CRC (2000)). Drug stock solutions for two compounds, are combined in ratios of 10:1, 5:1, 3:1, 1:1, 1:3, 1:5. These ratios, as well as the individual compound stock solutions, are diluted in a serial manner, using 70% DMSO. These serial dilutions are then mixed with RPMI growth medium, and added to cells to test the IC50 values of single agent as well as two compounds in the cellular proliferation assays. Combination Indexes with 95% confidence intervals were used to determine if the combination results represented synergistic, additive, or antagonistic effect. 
     Gene Expression Profiling: 
     RNA was isolated from the cultured cells using the RNeasy™ kits from Qiagen (Valencia, Calif.). 10 μg of total RNA from each cell line was used to prepare biotinylated probe according to the Affymetrix GeneChip® Expression Analysis Technical Manual, 2001. Targets were hybridized to Affymetrix high density oligonucleotide array human HG-U133A 2.0 GeneChip® (Affymetrix, Santa Clara, Calif.). The arrays were then washed and stained using the GeneChip® Fluidics station and quantitated with GeneChip® Operating Software (GCOS) V1.0 according to the manufacture&#39;s instructions. 
     Protein Extraction and Tryptic Digestion: 
     Total protein content for each cell lysate was determined by the bicinchoninic acid assay (Pierce, Rockford, Ill.). An aliquot from each lysate containing 200 μg total protein was withdrawn for further processing. 
     The normalized samples were chloroform-methanol precipitated using a protein extraction kit (Calbiochem, San Diego, Calif.). Pellets were solublized in a solution containing 8M urea, 200 mM ammonium bicarbonate, and 40 mM DTT. Samples were diluted 4-fold, trypsin was added at 1:50 enyzme:substrate ratio and incubated overnight at 37° C. 
     Solid Phase Extraction: 
     Solid phase extraction was performed using an Empore C18 SPE plate (3M, St Paul, Minn.) on a Quadr3 liquid handling workstation (Tomtec, Hamden, Conn.). Sample sequence on the plate was randomized to minimize systemic bias during processing. After sample loading, the SPE plate was washed with 450 μl water in 0.1% trifluoroacetic acid twice and eluted with 300 μl 95% acetonitrile in 0.1% trifluoroacetic acid twice. 
     Randomization, Duplication, and Lyophilization: 
     Samples were then split across two separate 96-well plates (VWR, West Chester, Pa.) in a separate randomized order. This process generated two technical replicates for each sample. Following lyophilization on a SpeedVac (Thermo Savant, Holbrook, N.Y.), samples were stored at −80° C. before analysis. 
     Liquid Chromatography—Mass Spectrometry: 
     Samples of tryptic peptides were separated on an Zorbax 300SB-C18 column (0.5×150 mm, 3.5 nm) from Agilent (Santa Clara, Calif.) equipped with a 0.5 μm pre-column filter (Opti-solve). The mobile phases were delivered at a total flow rate of 12 μl/min by an Agilent 1100 Capillary HPLC system. Mobile phase A was water in 0.2% isopropyl alcohol, 0.1% acetic acid and 0.001% trifluoroacetic acid; Mobile B was 95% acetonitrile in 0.2% isopropyl alcohol, 0.1% acetic acid and 0.001% trifluoroacetic acid. The following gradient was used to separate the peptides: 
     
       
         
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                   
                   
               
               
                   
                 Time (min) 
               
             
          
           
               
                   
                 0 
                 2 
                 4 
                 64 
                 69 
                 71 
                 71.1 
                 80 
               
               
                   
                   
               
             
          
           
               
                 % B 
                 0 
                 0 
                 10 
                 40 
                 100 
                 100 
                 0 
                 Stop 
               
               
                   
               
             
          
         
       
     
     Samples were re-dissolved in 40 μl reconstitution solution in 0.2% isopropyl alcohol, 5% acetic acid and 0.001% trifluoroacetic acid. Six microliters of sample was injected for each run using an Agilent 1100 micro well plate sampler chilled at 4° C. To achieve optimum mass accuracy, a peptide standard Glu-Fibrinopeptide B (Sigma, St. Louis, Mo.) was introduced through a Valco-type mixing tee into the flowing system immediately after the HPLC column outlet at 1 μl/min. The HPLC eluent was detected on a Qtof Ultima QqTOF hybrid mass spectrometer (Waters, Manchester, UK) operated in the electrospray positive ionization mode. Mass spectra were acquired for the mass range of 300 to 1800 Da. Each acquisition was 80 minutes long, with 1 second scan time and 0.1 second inter scan delay. Accuracy of the mass measurement was typically within 20 parts per million. A collection of proprietary algorithms (Extractor, Cluster and Time Adjustment) written in-house were applied to extract and quantify peptide peak information, adjust peaks for retention time shifts that may occur during HPLC separation and match peaks across runs. This preprocessing resulted the raw peptide expression measures for each sample. 
     Peptide Identification: 
     The peptide ions generated from statistical analyses were sequenced by tandem mass spectrometry (MS/MS). Samples were rerun onto the same LC-MS system in data dependant mode in which the MS survey scan would switch to MSMS product scan when targeted peptide ions were found at the same retention time and mass. MS/MS spectra were generated and submitted to SEQUEST search (J. Eng, et al., J. Am. Soc. Mass. Spectrom., 5: 976-989 (1994)) to yield protein identifications. 
     Statistical Analysis 
     Analysis of Baseline Gene and Protein Expression of 29 Cell Lines: 
     The gene expression raw data were normalized by the Robust Multichip Average (RMA, R. Irizarry, et al., Biostatistics;4(2):249-64 (2003)) method and log 2  transformed, while the protein profiling data was quantile normalized and log2 transformed. To identify genes or proteins whose expression level significantly correlation with the drug sensitivity for the compounds, two separate statistic analyses were performed. First, a two-sample t-test between the resistant and sensitive cell lines (based on a threshold IC 50  cutoff of 0.35 μM) was performed. Second, Pearson correlation between the normalized expression level of each gene/protein and the log2(IC 50 ) values of the 29 cell lines was calculated to identify genes/proteins correlated with the drug sensitivity (IC 50 ). 
     Analysis of Gene and Protein Expression Data of Cells with Drug Treatment: 
     Pre-filter was applied to both gene and protein expression data. Lowly expressed probe sets with normalized and log 2  transformed expression values less than 5 cross all samples were removed resulting probe sets of 10,479 for gene expression data. For peptide, it must be found in at least 15 LCMS experimental runs and for subsequent statistical analysis in at least 20 cell lines. This filter reduced the number of overall peptides to 9022 for further analysis. A two-way ANOVA mixed model was applied to each probe set in the gene expression profiling data, as well as each peptide in the protein expression profiling data, separately. The model that was applied to each dataset was nearly identical except for a single term in the model applied to the protein expression data which appropriately accounted for the existence of the technical replicates. The analysis was run using SAS version 9.1 (SAS Institute Inc., Cary, N.C., USA). The general form of the model was as follows: (Intensity˜Treatment+Time+Treatment×Time+Error) where Intensity represents the normalized, log2 transformed intensity; Treatment is a term that captures candidates that display significant differential expression upon treatment; Time is a term that captures candidates that display significant differential expression over time; and the Treatment×Time term captures candidates that display significant differential expression upon treatment with compound over time as compared with control. The multiple testing with False Discovery Rate (FDR; Y. Benjamini, et al., J. Roy. Stat. Soc. B.; 57:289-300 (1995)) was apply to each dataset separately, the total of 2056 probe sets with FDR p value&lt;0.05 in either the Treatment effect or Treatment×Time interaction and the fold change between treatment group vs. DMSO control group is greater than 1.2 fold or less than −1.2 fold were selected. 
     Globaltest Pathway Analysis: 
     RMA normalized baseline expression data for 28 sarcoma cell lines was first filtered based on following criteria: 1) Maximal expression level across all samples must be greater than 5; 2) Coefficient of Variation (CV) must by greater than 0.03. These resulted a total of 17276 probe sets for further analysis. Globaltest was carried out with Bioconductor (www.bioconductor.org) package (Version 4.4.0) using this filtered dataset and compound 1 resistant/sensitive classification for each cell line against a collection of 183 KEGG pathways. The p value indicating the association between expression values and resistant/sensitive classifications, as well as its multiplicity-adjusted version, FWER (Holm&#39;s method), were reported for each pathway. Gene plots were generated for interesting pathways according to user&#39;s guide (J. Geoman, et al., Testing association of a pathway with a clinical variable. Package globaltest. Version 4.4.0. (October 2006)) and used to assess the influence of each gene in a specific pathway on the drug sensitivity classification. For Rh41 drug treatment study, expression datasets were first filtered to remove probe sets whose maximal expression level less than 5, which resulted 9269 probe sets. Globaltest was carried out similar as above, with treatment (DMSO control vs. compound 1) as grouping factor. It gives a bar and a reference line for each gene tested. The reference line for each bar gives the expected height under the null hypothesis that the gene is not associated with the sensitivity classification. Marks indicate with how many standard deviations (under the null hypothesis) the bar exceeds the reference line. Bars are colored based on sensitivity classification. The test statistic for a pathway is the average of the bars for all the genes tested. 
     Ingenuity Pathway Analysis: 
     497 baseline markers correlated with sensitivity to compound 1 were imported into Ingenuity pathway analysis. Network nodes were colored by the fold change between sensitive and resistant cells. For the drug modulated markers, treatment-induced probe sets in the sensitive cell line Rh41 (FDR adjusted treatment effect less than 0.05, or FDR adjusted treatment-time-interaction less than 0.05) were used for pathway analysis. Genes on canonical pathways were colored based on the fold change between cells with compound 1 treatment and DMSO control. 
     Results 
     The Sensitivity Classification of the 29 Pediatric Sarcoma Cell Lines to IGF1R Inhibitors: 
     The sensitivity to IGF1R inhibitors compound 1 and compound 2 for each of the 29 pediatric sarcoma and neuroblastoma cell lines was determined by cellular proliferation assays and expressed in term of drug concentration required for 50% cell proliferation inhibition (IC 50 ). The results are summarized in Table 1, and a wide range of activity in this panel of cancer cell lines was observed for both compound 1 and compound 2 compounds. 
                                                                         TABLE 1                   The IC 50  of each cell line and sensitive/resistant classification to       compounds 2 and 1.                        Compound 2       Compound 1               Compound 2   Sensitivity   Compound   Sensitivity       Cell Type   Cell Line   IC 50  (uM)   Classification   1 IC 50  (uM)   Classification                    Ewing   TC32   0.0084   S   0.055   S       Ewing   RDES   0.0117   S   0.123   S       Ewing   TC71   0.0143   S   0.119   S       Ewing   VW   0.019   S   0.101   S       Ewing   5838   0.034   S   0.172   S       Ewing   LG   0.0375   S   0.063   S       Ewing   JD   0.391   R   0.232   S       Ewing   KAG   1.665   R   2.113   R       Fibrosarcoma   HT1080/S   0.531   R   1.409   R       Fibrosarcoma   SW-684   5   R   5   R       Leiomyosarcoma   SK-   0.6866   R   0.5   R           LMS-1       Liposarcoma   To184.T   0.4695   R   not tested   not tested       Liposarcoma   HTB-92   1.0199   R   0.584   R       Liposarcoma   SA-4   1.3007   R   0.779   R       Melignant Pleural   H211   0.733   R   0.418   R       Mesothelioma       Melignant Pleural   H2052   1.0502   R   0.403   R       Mesothelioma       Melignant Pleural   H513   4.448   R   3.117   R       Mesothelioma       Melignant Pleural   H2595   4.4752   R   5   R       Mesothelioma       Neuroblastoma   LAN-1   0.04   S   0.136   S       Neuroblastoma   SHSY5Y   0.106   S   0.149   S       Neuroblastoma   SK-NSH   0.139   S   0.196   S       Neuroblastoma   IMR-32   0.261   S   0.277   S       Neuroblastoma   SK-NAS   0.497   R   0.192   S       Rhabdomyosarcoma   Rh4   0.004   S   0.027   S       Rhabdomyosarcoma   Rh41   0.0047   S   0.069   S       Rhabdomyosarcoma   ME   0.015   S   0.163   S       Rhabdomyosarcoma   Rh1   0.0267   S   0.135   S       Rhabdomyosarcoma   CTR   0.2526   S   0.37   R       Rhabdomyosarcoma   Rh36   1.432   R   1.6   R               “S” means sensitive and       “R” means resistant to the corresponding compounds.       The cell subtypes are also indicated.            
Comparing the IC 50  data of these two compounds, compound 2 is more potent than compound 1 in most of the cell lines tested. To classify the cell lines as sensitive or resistant to the compounds, the IC 50  value for each cell line was log-transformed, and the mean of log 10 (IC 50 ) across all cell lines was calculated. The sensitivity/resistance phenotype of the cell lines to compound 1 or compound 2 was classified as follows: the cell lines with log 10 (IC 50 ) below the mean log 10 (IC 50 ) of all cell lines were defined as sensitive to the compound, while those with log 10 (IC 50 ) above the mean log 10 (IC 50 ) were considered to be resistant to the compound. As shown in Table 1, 16 cell lines were classified as sensitive and 12 cell lines classified as resistant (To184-T was not tested) for compound 1; whereas 15 and 14 cell lines were classified as either sensitive or resistant to compound 2, respectively. Although the sensitivity/resistance demarcation is arbitrary, apparently, the cut off is around 0.35 μM for both compounds. In general, both compounds have a similar sensitivity/resistance profile in this panel of cell lines with the exception of three cell lines that having IC 50  values around the borderline of the sensitive/resistant demarcation: CTR was defined as sensitive to compound 2 (IC 50 =0.2526 μM) but resistant to compound 1 (IC 50 =0.37 μM), whereas JD and SK-NAS were defined as resistant to compound 2 but resistant to compound 1.
 
Relation Between the Drug Sensitivity and Cell Subtypes:
 
     The correlation between the sensitive/resistant classification and different subtypes of cell lines was further explored. Interestingly, the sensitivity of these cell lines to IGF1R inhibitor compounds was found to be closely related to specific subtypes. As shown in Table 1, most of Ewing&#39;s, RMS and neuroblastoma cells are sensitive to the compounds, whereas all fibrosarcoma, leiomyosarcoma, liposarcoma and malignant pleural mesothelioma cells are resistant. The distribution of cell sub-types is significantly different in sensitive and resistant classes with p-value=0.011 for compound 2 and p-value=0.004 for compound 1, respectively in the chi-square test. Although the sample size for each subtype is not big enough to be conclusive, the results may suggest that certain subtypes of sarcoma are more responsive than others, and these responsive tumor types may represent patient subpopulations to be targeted in clinical studies for IGF1R inhibitors. 
     Identification of Genes/Proteins with Expression Significantly Correlated with the Sensitivity to IGF1R Inhibitors: 
     The expression level of the drug target IGF1R was evaluated and apparently did not significantly correlate to the sensitivity of compound 2 and/or compound 1 in the 29 cancer cell lines, so IGF1R level is not useful to predict response to compound 2 and/or compound 1 in cancer cells or in patients. Other predictive biomarkers are needed for selecting the potential targeted patient population. 
     To identify genes or proteins whose basal expression patterns were strongly correlated with the sensitivity to compounds 1 and 2, gene expression profiling and proteomics were performed in parallel using the 29 pediatric sarcoma and neuroblastoma cancer cell lines (RDES and Rh4 were not included in protein profiling). Two statistical methods were used in analyzing both expression datasets: first, two sample t-test was performed to identify genes differentially expressed between sensitive and resistant cell line groups (p&lt;0.001, 2-fold); second, to avoid the bias of arbitrary cut off for the sensitive/resistant demarcation, the Pearson correlations between the log2(IC 50 ) value and the expression level of each gene or protein in all cell lines were calculated to identify genes/proteins significantly correlated with the drug sensitivity (p&lt;0.001). The overlap between these two analyses led to selection of genes/proteins that are significantly correlated with the drug sensitivity/resistance classification for compound 1 or compound 2. For gene expression profiling, there are a total of 497 probe sets with 386 unique genes significantly correlated with the sensitivity to compound 1 (Table 2), and 368 probe sets with 282 unique genes significantly correlated with the sensitivity to compound 2 (Table 3); and. There are 98 or 124 genes highly expressed in the cell lines sensitive to compound 2 or to compound 1, conversely, 184 or 262 genes are highly expressed in the cell lines resistant to compound 2 or compound 1, respectively, with 227 common markers for these two compounds. 
     
       
         
               
             
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Genes correlated with the sensitivity of 28 sarcoma cell lines to 
               
               
                 compound 1 as identified by Affymetrix gene array. 
               
             
          
           
               
                   
                   
                   
                 Gene 
                 p-value 
                 Fold 
                 p-value 
               
               
                 probe 
                 Accession # 
                 Gene Title 
                 Symbol 
                 in t-test 
                 (S/R) 
                 (correlation) 
               
               
                   
               
             
          
           
               
                 Genes higher expressed in the group of sensitive cell 
               
               
                 lines 
               
             
          
           
               
                 214451_at 
                 NM_003221 
                 transcription factor AP- 
                 TFAP2B 
                 1.3E−05 
                 56.6 
                 4.3E−04 
               
               
                   
                   
                 2 beta (activating 
               
               
                   
                   
                 enhancer binding 
               
               
                   
                   
                 protein 2 beta) 
               
               
                 212713_at 
                 R72286 
                 microfibrillar- 
                 MFAP4 
                 1.7E−06 
                 14.5 
                 9.9E−05 
               
               
                   
                   
                 associated protein 4 
               
               
                 204915_s_at 
                 AB028641 
                 SRY (sex determining 
                 SOX11 
                 1.7E−07 
                 13.4 
                 4.3E−05 
               
               
                   
                   
                 region Y)-box 11 
               
               
                 216623_x_at 
                 AK025084 
                 trinucleotide repeat 
                 TNRC9 
                 3.2E−04 
                 13.2 
                 5.5E−04 
               
               
                   
                   
                 containing 9 
               
               
                 221011_s_at 
                 NM_030915 
                 limb bud and heart 
                 LBH 
                 7.1E−05 
                 12.2 
                 4.7E−04 
               
               
                   
                   
                 development homolog 
               
               
                   
                   
                 (mouse) /// limb bud 
               
               
                   
                   
                 and heart development 
               
               
                   
                   
                 homolog (mouse) 
               
               
                 202517_at 
                 NM_001313 
                 collapsin response 
                 CRMP1 
                 3.0E−06 
                 11.3 
                 4.1E−04 
               
               
                   
                   
                 mediator protein 1 
               
               
                 205888_s_at 
                 AI962693 
                 janus kinase and 
                 JAKMIP2 /// 
                 3.1E−08 
                 9.3 
                 1.1E−05 
               
               
                   
                   
                 microtubule interacting 
                 MYT1L 
               
               
                   
                   
                 protein 2 /// myelin 
               
               
                   
                   
                 transcription factor 1- 
               
               
                   
                   
                 like 
               
               
                 207781_s_at 
                 NM_021998 
                 zinc finger protein 711 
                 ZNF711 
                 9.2E−12 
                 8.1 
                 3.6E−07 
               
               
                 221748_s_at 
                 AL046979 
                 tensin 1 /// tensin 1 
                 TNS1 
                 5.4E−05 
                 7.8 
                 4.3E−04 
               
               
                 213170_at 
                 AA406605 
                 glutathione peroxidase 7 
                 GPX7 
                 2.0E−05 
                 7.4 
                 1.6E−04 
               
               
                 205123_s_at 
                 NM_003692 
                 transmembrane protein 
                 TMEFF1 
                 1.2E−05 
                 6.9 
                 1.0E−04 
               
               
                   
                   
                 with EGF-like and two 
               
               
                   
                   
                 follistatin-like domains 1 
               
               
                 203999_at 
                 AV731490 
                 — 
                 — 
                 1.6E−06 
                 6.7 
                 9.2E−04 
               
               
                 218445_at 
                 NM_018649 
                 H2A histone family, 
                 H2AFY2 
                 1.2E−07 
                 6.3 
                 9.7E−05 
               
               
                   
                   
                 member Y2 
               
               
                 215043_s_at 
                 X83301 
                 SMA3 /// SMA5 
                 SMA3 /// 
                 4.0E−07 
                 6.2 
                 1.5E−05 
               
               
                   
                   
                   
                 SMA5 
               
               
                 209598_at 
                 AB020690 
                 paraneoplastic antigen 
                 PNMA2 
                 2.5E−05 
                 6.1 
                 1.4E−04 
               
               
                   
                   
                 MA2 
               
               
                 212382_at 
                 BF433429 
                 Transcription factor 4 
                 TCF4 
                 1.3E−06 
                 5.8 
                 1.0E−04 
               
               
                 212386_at 
                 BF592782 
                 CDNA FLJ11918 fis, 
                 — 
                 1.6E−06 
                 5.7 
                 6.0E−06 
               
               
                   
                   
                 clone HEMBB1000272 
               
               
                 205889_s_at 
                 NM_014790 
                 janus kinase and 
                 JAKMIP2 
                 9.6E−08 
                 5.5 
                 4.5E−06 
               
               
                   
                   
                 microtubule interacting 
               
               
                   
                   
                 protein 2 
               
               
                 205830_at 
                 NM_004362 
                 calmegin 
                 CLGN 
                 5.6E−08 
                 5.4 
                 4.4E−07 
               
               
                 211071_s_at 
                 BC006471 
                 myeloid/lymphoid or 
                 MLLT11 
                 1.9E−05 
                 5.3 
                 5.7E−04 
               
               
                   
                   
                 mixed-lineage leukemia 
               
               
                   
                   
                 (trithorax homolog, 
               
               
                   
                   
                   Drosophila ); 
               
               
                   
                   
                 translocated to, 11 /// 
               
               
                   
                   
                 myeloid/lymphoid or 
               
               
                   
                   
                 mixed-lineage leukemia 
               
               
                   
                   
                 (trithorax homolog, 
               
               
                   
                   
                   Drosophila ); 
               
               
                   
                   
                 translocated to, 11 
               
               
                 212599_at 
                 AK025298 
                 autism susceptibility 
                 AUTS2 
                 2.1E−05 
                 5.3 
                 1.8E−05 
               
               
                   
                   
                 candidate 2 
               
               
                 206440_at 
                 NM_004664 
                 lin-7 homolog A ( C. elegans ) 
                 LIN7A 
                 9.1E−04 
                 4.8 
                 3.2E−04 
               
               
                 206565_x_at 
                 NM_006780 
                 SMA3 
                 SMA3 
                 9.0E−07 
                 4.7 
                 4.6E−06 
               
               
                 219855_at 
                 NM_018159 
                 nudix (nucleoside 
                 NUDT11 
                 3.8E−04 
                 4.7 
                 8.1E−04 
               
               
                   
                   
                 diphosphate linked 
               
               
                   
                   
                 moiety X)-type motif 
               
               
                   
                   
                 11 
               
               
                 213131_at 
                 R38389 
                 olfactomedin 1 
                 OLFM1 
                 1.6E−04 
                 4.7 
                 6.0E−04 
               
               
                 200884_at 
                 NM_001823 
                 creatine kinase, brain 
                 CKB 
                 2.8E−07 
                 4.6 
                 9.8E−07 
               
               
                 206655_s_at 
                 NM_000407 
                 glycoprotein Ib 
                 GP1BB /// 
                 1.2E−05 
                 4.5 
                 9.1E−04 
               
               
                   
                   
                 (platelet), beta 
                 SEPT5 
               
               
                   
                   
                 polypeptide /// septin 5 
               
               
                 214023_x_at 
                 AL533838 
                 tubulin, beta 2B 
                 TUBB2B 
                 5.4E−04 
                 4.5 
                 1.5E−04 
               
               
                 204860_s_at 
                 AI817801 
                 NLR family, apoptosis 
                 NAIP /// 
                 3.0E−05 
                 4.2 
                 1.1E−04 
               
               
                   
                   
                 inhibitory protein /// 
                 LOC728519 
               
               
                   
                   
                 similar to Baculoviral 
               
               
                   
                   
                 IAP repeat-containing 
               
               
                   
                   
                 protein 1 (Neuronal 
               
               
                   
                   
                 apoptosis inhibitory 
               
               
                   
                   
                 protein) 
               
               
                 208998_at 
                 U94592 
                 uncoupling protein 2 
                 UCP2 
                 2.6E−06 
                 4.2 
                 6.1E−06 
               
               
                   
                   
                 (mitochondrial, proton 
               
               
                   
                   
                 carrier) 
               
               
                 204165_at 
                 NM_003931 
                 WAS protein family, 
                 WASF1 
                 2.7E−07 
                 4.1 
                 1.1E−05 
               
               
                   
                   
                 member 1 
               
               
                 212847_at 
                 AL036840 
                 Far upstream element 
                 FUBP1 
                 1.0E−07 
                 4.1 
                 1.2E−04 
               
               
                   
                   
                 (FUSE) binding protein 1 
               
               
                 213216_at 
                 AL537463 
                 OTU domain 
                 OTUD3 
                 9.8E−06 
                 3.9 
                 1.9E−05 
               
               
                   
                   
                 containing 3 
               
               
                 213547_at 
                 AB014567 
                 cullin-associated and 
                 CAND2 
                 3.3E−05 
                 3.7 
                 2.1E−05 
               
               
                   
                   
                 neddylation-dissociated 
               
               
                   
                   
                 2 (putative) 
               
               
                 204742_s_at 
                 NM_015032 
                 androgen-induced 
                 APRIN 
                 8.9E−06 
                 3.5 
                 1.5E−05 
               
               
                   
                   
                 proliferation inhibitor 
               
               
                 213605_s_at 
                 AL049987 
                 Similar to Beta- 
                 LOC728411 
                 1.6E−05 
                 3.5 
                 3.5E−05 
               
               
                   
                   
                 glucuronidase precursor 
               
               
                 204457_s_at 
                 NM_002048 
                 growth arrest-specific 1 
                 GAS1 
                 1.4E−04 
                 3.4 
                 1.1E−04 
               
               
                 214102_at 
                 AK023737 
                 centaurin, delta 1 
                 CENTD1 
                 1.9E−06 
                 3.4 
                 5.6E−06 
               
               
                 201449_at 
                 AL567227 
                 TIA1 cytotoxic 
                 TIA1 
                 1.3E−08 
                 3.4 
                 2.4E−05 
               
               
                   
                   
                 granule-associated 
               
               
                   
                   
                 RNA binding protein 
               
               
                 205347_s_at 
                 NM_021992 
                 thymosin-like 8 
                 TMSL8 
                 7.6E−05 
                 3.3 
                 1.2E−04 
               
               
                 212816_s_at 
                 BE613178 
                 cystathionine-beta- 
                 CBS 
                 5.8E−05 
                 3.2 
                 5.6E−04 
               
               
                   
                   
                 synthase 
               
               
                 214850_at 
                 X75940 
                 glucuronidase, beta 
                 GUSBP1 
                 4.9E−06 
                 3.2 
                 1.4E−04 
               
               
                   
                   
                 pseudogene 1 
               
               
                 212731_at 
                 U79297 
                 ankyrin repeat domain 
                 ANKRD46 
                 1.8E−07 
                 3.2 
                 2.2E−06 
               
               
                   
                   
                 46 
               
               
                 221965_at 
                 AI990326 
                 M-phase 
                 MPHOSPH9 
                 1.6E−07 
                 3.1 
                 8.2E−06 
               
               
                   
                   
                 phosphoprotein 9 
               
               
                 213283_s_at 
                 BG285616 
                 sal-like 2 ( Drosophila ) 
                 SALL2 
                 2.7E−06 
                 3.1 
                 2.4E−05 
               
               
                 200644_at 
                 NM_023009 
                 MARCKS-like 1 
                 MARCKSL1 
                 2.8E−05 
                 3.1 
                 1.8E−05 
               
               
                 210882_s_at 
                 U04811 
                 trophinin 
                 TRO 
                 2.2E−05 
                 3.0 
                 4.4E−05 
               
               
                 204040_at 
                 NM_014746 
                 ring finger protein 144 
                 RNF144 
                 1.8E−04 
                 3.0 
                 1.9E−04 
               
               
                 203069_at 
                 NM_014849 
                 synaptic vesicle 
                 SV2A 
                 3.1E−04 
                 3.0 
                 8.0E−04 
               
               
                   
                   
                 glycoprotein 2A 
               
               
                 215146_s_at 
                 AB028966 
                 tetratricopeptide repeat 
                 TTC28 
                 7.9E−07 
                 3.0 
                 1.4E−08 
               
               
                   
                   
                 domain 28 
               
               
                 213610_s_at 
                 BE326381 
                 kelch-like 23 
                 KLHL23 
                 7.0E−06 
                 2.9 
                 5.1E−05 
               
               
                   
                   
                 ( Drosophila ) 
               
               
                 202967_at 
                 NM_001512 
                 glutathione S- 
                 GSTA4 
                 1.2E−04 
                 2.9 
                 3.1E−04 
               
               
                   
                   
                 transferase A4 
               
               
                 218223_s_at 
                 NM_016274 
                 pleckstrin homology 
                 PLEKHO1 
                 5.9E−07 
                 2.9 
                 1.2E−07 
               
               
                   
                   
                 domain containing, 
               
               
                   
                   
                 family O member 1 
               
               
                 221261_x_at 
                 NM_030801 
                 melanoma antigen 
                 MAGED4 
                 1.9E−05 
                 2.9 
                 9.3E−06 
               
               
                   
                   
                 family D, 4 /// 
               
               
                   
                   
                 melanoma antigen 
               
               
                   
                   
                 family D, 4 
               
               
                 212624_s_at 
                 BF339445 
                 chimerin (chimaerin) 1 
                 CHN1 
                 9.7E−05 
                 2.9 
                 1.5E−04 
               
               
                 215599_at 
                 X83300 
                 SMA4 /// similar to 
                 SMA4 /// 
                 9.8E−06 
                 2.8 
                 1.3E−04 
               
               
                   
                   
                 SMA4 
                 LOC730390 
               
               
                 212126_at 
                 BG391282 
                 CDNA clone 
                 — 
                 1.4E−07 
                 2.8 
                 7.4E−05 
               
               
                   
                   
                 IMAGE: 4842353 
               
               
                 209153_s_at 
                 M31523 
                 transcription factor 3 
                 TCF3 
                 1.4E−06 
                 2.8 
                 9.7E−05 
               
               
                   
                   
                 (E2A immunoglobulin 
               
               
                   
                   
                 enhancer binding 
               
               
                   
                   
                 factors E12/E47) 
               
               
                 214724_at 
                 AF070621 
                 DIX domain containing 1 
                 DIXDC1 
                 1.8E−05 
                 2.7 
                 2.8E−04 
               
               
                 208986_at 
                 AL559478 
                 transcription factor 12 
                 TCF12 
                 2.3E−06 
                 2.7 
                 2.7E−07 
               
               
                   
                   
                 (HTF4, helix-loop-helix 
               
               
                   
                   
                 transcription factors 4) 
               
               
                 213626_at 
                 AL049442 
                 carbonyl reductase 4 
                 CBR4 
                 9.6E−06 
                 2.7 
                 3.3E−04 
               
               
                 218868_at 
                 NM_020445 
                 ARP3 actin-related 
                 ACTR3B 
                 6.8E−06 
                 2.6 
                 6.9E−04 
               
               
                   
                   
                 protein 3 homolog B 
               
               
                   
                   
                 (yeast) 
               
               
                 203298_s_at 
                 NM_004973 
                 jumonji, AT rich 
                 JARID2 
                 1.3E−07 
                 2.6 
                 1.6E−04 
               
               
                   
                   
                 interactive domain 2 
               
               
                 37577_at 
                 U79256 
                 Rho GTPase activating 
                 ARHGAP19 
                 4.1E−05 
                 2.6 
                 1.1E−04 
               
               
                   
                   
                 protein 19 
               
               
                 212482_at 
                 BF671894 
                 required for meiotic 
                 RMND5A 
                 1.8E−06 
                 2.5 
                 1.9E−04 
               
               
                   
                   
                 nuclear division 5 
               
               
                   
                   
                 homolog A ( S. cerevisiae ) 
               
               
                 204173_at 
                 NM_002475 
                 myosin, light chain 6B, 
                 MYL6B 
                 9.9E−04 
                 2.5 
                 7.4E−04 
               
               
                   
                   
                 alkali, smooth muscle 
               
               
                   
                   
                 and non-muscle 
               
               
                 203151_at 
                 AW296788 
                 microtubule-associated 
                 MAP1A 
                 2.3E−04 
                 2.5 
                 7.7E−04 
               
               
                   
                   
                 protein 1A 
               
               
                 212919_at 
                 AV715578 
                 DCP2 decapping 
                 DCP2 
                 1.1E−06 
                 2.5 
                 3.3E−05 
               
               
                   
                   
                 enzyme homolog ( S. cerevisiae ) 
               
               
                 213694_at 
                 AW027347 
                 round spermatid basic 
                 RSBN1 
                 9.2E−07 
                 2.5 
                 2.8E−04 
               
               
                   
                   
                 protein 1 
               
               
                 203625_x_at 
                 BG105365 
                 melanoma cell adhesion 
                 MCAM 
                 1.8E−04 
                 2.5 
                 1.4E−04 
               
               
                   
                   
                 molecule 
               
               
                 204795_at 
                 NM_025263 
                 proline rich 3 
                 PRR3 
                 1.0E−05 
                 2.5 
                 2.0E−04 
               
               
                 212670_at 
                 AA479278 
                 elastin (supravalvular 
                 ELN 
                 2.0E−05 
                 2.5 
                 1.4E−04 
               
               
                   
                   
                 aortic stenosis, 
               
               
                   
                   
                 Williams-Beuren 
               
               
                   
                   
                 syndrome) 
               
               
                 212547_at 
                 N34842 
                 FLJ35348 
                 FLJ35348 
                 9.4E−07 
                 2.5 
                 7.2E−05 
               
               
                 210567_s_at 
                 BC001441 
                 S-phase kinase- 
                 SKP2 
                 6.7E−04 
                 2.4 
                 4.1E−04 
               
               
                   
                   
                 associated protein 2 
               
               
                   
                   
                 (p45) 
               
               
                 209748_at 
                 AB029006 
                 spastin 
                 SPAST 
                 4.0E−07 
                 2.4 
                 3.8E−04 
               
               
                 215128_at 
                 AV704232 
                 CDNA FLJ11682 fis, 
                 — 
                 4.7E−05 
                 2.4 
                 4.5E−04 
               
               
                   
                   
                 clone HEMBA1004880 
               
               
                 203825_at 
                 NM_007371 
                 bromodomain 
                 BRD3 
                 1.2E−06 
                 2.4 
                 4.5E−05 
               
               
                   
                   
                 containing 3 
               
               
                 214220_s_at 
                 AW003635 
                 Alstrom syndrome 1 
                 ALMS1 
                 1.4E−06 
                 2.4 
                 1.6E−05 
               
               
                 210045_at 
                 AU151428 
                 isocitrate 
                 IDH2 
                 6.1E−06 
                 2.4 
                 5.7E−04 
               
               
                   
                   
                 dehydrogenase 2 
               
               
                   
                   
                 (NADP+), 
               
               
                   
                   
                 mitochondrial 
               
               
                 218683_at 
                 NM_021190 
                 polypyrimidine tract 
                 PTBP2 
                 1.5E−06 
                 2.4 
                 5.8E−04 
               
               
                   
                   
                 binding protein 2 
               
               
                 218457_s_at 
                 NM_022552 
                 DNA (cytosine-5-)- 
                 DNMT3A 
                 2.2E−06 
                 2.4 
                 7.2E−05 
               
               
                   
                   
                 methyltransferase 3 
               
               
                   
                   
                 alpha 
               
               
                 204061_at 
                 NM_005044 
                 protein kinase, X- 
                 PRKX 
                 6.2E−06 
                 2.4 
                 2.3E−05 
               
               
                   
                   
                 linked 
               
               
                 210649_s_at 
                 AF231056 
                 AT rich interactive 
                 ARID1A 
                 7.1E−07 
                 2.4 
                 7.2E−08 
               
               
                   
                   
                 domain 1A (SWI-like) 
               
               
                 212153_at 
                 AB007930 
                 pogo transposable 
                 POGZ 
                 8.7E−08 
                 2.4 
                 6.1E−05 
               
               
                   
                   
                 element with ZNF 
               
               
                   
                   
                 domain 
               
               
                 218265_at 
                 NM_024077 
                 SECIS binding protein 2 
                 SECISBP2 
                 1.1E−06 
                 2.4 
                 2.2E−05 
               
               
                 210543_s_at 
                 U34994 
                 protein kinase, DNA- 
                 PRKDC 
                 5.0E−04 
                 2.3 
                 1.3E−04 
               
               
                   
                   
                 activated, catalytic 
               
               
                   
                   
                 polypeptide 
               
               
                 220443_s_at 
                 NM_012476 
                 ventral anterior 
                 VAX2 
                 2.0E−04 
                 2.3 
                 5.1E−04 
               
               
                   
                   
                 homeobox 2 
               
               
                 202561_at 
                 AF070613 
                 tankyrase, TRF1- 
                 TNKS 
                 1.4E−04 
                 2.3 
                 4.6E−04 
               
               
                   
                   
                 interacting ankyrin- 
               
               
                   
                   
                 related ADP-ribose 
               
               
                   
                   
                 polymerase 
               
               
                 203795_s_at 
                 NM_020993 
                 B-cell CLL/lymphoma 
                 BCL7A 
                 3.1E−06 
                 2.3 
                 3.3E−04 
               
               
                   
                   
                 7A 
               
               
                 213387_at 
                 AB033066 
                 ATPase family, AAA 
                 ATAD2B 
                 2.5E−06 
                 2.3 
                 1.0E−04 
               
               
                   
                   
                 domain containing 2B 
               
               
                 203046_s_at 
                 NM_003920 
                 timeless homolog 
                 TIMELESS 
                 6.7E−07 
                 2.3 
                 7.1E−06 
               
               
                   
                   
                 ( Drosophila ) 
               
               
                 211929_at 
                 AA527502 
                 heterogeneous nuclear 
                 HNRPA3 
                 1.8E−05 
                 2.3 
                 1.8E−04 
               
               
                   
                   
                 ribonucleoprotein A3 
               
               
                 222101_s_at 
                 BF222893 
                 dachsous 1 
                 DCHS1 
                 5.2E−04 
                 2.3 
                 2.3E−04 
               
               
                   
                   
                 ( Drosophila ) 
               
               
                 203940_s_at 
                 NM_014909 
                 vasohibin 1 
                 VASH1 
                 6.0E−04 
                 2.3 
                 1.8E−04 
               
               
                 203026_at 
                 NM_014872 
                 zinc finger and BTB 
                 ZBTB5 
                 3.7E−08 
                 2.3 
                 5.5E−05 
               
               
                   
                   
                 domain containing 5 
               
               
                 212164_at 
                 AL522296 
                 transmembrane protein 
                 TMEM183A 
                 1.1E−06 
                 2.2 
                 1.7E−04 
               
               
                   
                   
                 183A 
               
               
                 207705_s_at 
                 NM_025176 
                 KIAA0980 protein 
                 RP4- 
                 1.4E−04 
                 2.2 
                 9.6E−05 
               
               
                   
                   
                   
                 691N24.1 
               
               
                 210962_s_at 
                 AB019691 
                 A kinase (PRKA) 
                 AKAP9 
                 5.2E−08 
                 2.2 
                 2.0E−05 
               
               
                   
                   
                 anchor protein (yotiao) 9 
               
               
                 210555_s_at 
                 U85430 
                 nuclear factor of 
                 NFATC3 
                 5.4E−07 
                 2.2 
                 5.1E−05 
               
               
                   
                   
                 activated T-cells, 
               
               
                   
                   
                 cytoplasmic, 
               
               
                   
                   
                 calcineurin-dependent 3 
               
               
                 220040_x_at 
                 NM_018684 
                 KIAA1166 
                 KIAA1166 
                 1.8E−05 
                 2.2 
                 8.6E−04 
               
               
                 220735_s_at 
                 NM_020654 
                 SUMO1/sentrin 
                 SENP7 
                 1.0E−04 
                 2.2 
                 2.3E−04 
               
               
                   
                   
                 specific peptidase 7 
               
               
                 220143_x_at 
                 NM_018032 
                 LUC7-like ( S. cerevisiae ) 
                 LUC7L 
                 3.0E−06 
                 2.2 
                 2.0E−04 
               
               
                 221203_s_at 
                 NM_018023 
                 YEATS domain 
                 YEATS2 
                 6.8E−08 
                 2.2 
                 1.1E−08 
               
               
                   
                   
                 containing 2 
               
               
                 212710_at 
                 AL043774 
                 calmodulin regulated 
                 CAMSAP1 
                 2.0E−05 
                 2.2 
                 8.7E−04 
               
               
                   
                   
                 spectrin-associated 
               
               
                   
                   
                 protein 1 
               
               
                 208838_at 
                 AB020636 
                 — 
                 — 
                 1.4E−04 
                 2.2 
                 5.7E−06 
               
               
                 218724_s_at 
                 NM_021809 
                 TGFB-induced factor 2 
                 TGIF2 
                 3.2E−04 
                 2.2 
                 7.7E−05 
               
               
                   
                   
                 (TALE family 
               
               
                   
                   
                 homeobox) 
               
               
                 206554_x_at 
                 NM_006515 
                 SET domain and 
                 SETMAR 
                 6.6E−04 
                 2.2 
                 1.7E−04 
               
               
                   
                   
                 mariner transposase 
               
               
                   
                   
                 fusion gene 
               
               
                 202540_s_at 
                 NM_000859 
                 3-hydroxy-3- 
                 HMGCR 
                 4.0E−05 
                 2.2 
                 4.6E−05 
               
               
                   
                   
                 methylglutaryl- 
               
               
                   
                   
                 Coenzyme A reductase 
               
               
                 204060_s_at 
                 NM_005044 
                 protein kinase, X- 
                 PRKX /// 
                 6.8E−05 
                 2.2 
                 4.9E−05 
               
               
                   
                   
                 linked /// protein 
                 PRKY 
               
               
                   
                   
                 kinase, Y-linked 
               
               
                 203859_s_at 
                 NM_002579 
                 paralemmin 
                 PALM 
                 2.4E−05 
                 2.1 
                 7.1E−04 
               
               
                 209431_s_at 
                 AF254083 
                 POZ (BTB) and AT 
                 PATZ1 
                 5.4E−06 
                 2.1 
                 4.5E−04 
               
               
                   
                   
                 hook containing zinc 
               
               
                   
                   
                 finger 1 
               
               
                 212704_at 
                 AI049962 
                 zinc finger, CCHC 
                 ZCCHC11 
                 5.6E−06 
                 2.1 
                 5.2E−05 
               
               
                   
                   
                 domain containing 11 
               
               
                 207401_at 
                 NM_002763 
                 prospero-related 
                 PROX1 
                 3.7E−04 
                 2.1 
                 5.1E−04 
               
               
                   
                   
                 homeobox 1 
               
               
                 204557_s_at 
                 NM_014934 
                 DAZ interacting protein 1 
                 DZIP1 
                 6.7E−04 
                 2.1 
                 6.8E−06 
               
               
                 212753_at 
                 AI692203 
                 polycomb group ring 
                 PCGF3 
                 8.9E−08 
                 2.1 
                 1.9E−04 
               
               
                   
                   
                 finger 3 
               
               
                 201051_at 
                 BE560202 
                 acidic (leucine-rich) 
                 ANP32A 
                 5.9E−05 
                 2.1 
                 5.0E−04 
               
               
                   
                   
                 nuclear phosphoprotein 
               
               
                   
                   
                 32 family, member A 
               
               
                 212693_at 
                 BE670928 
                 MDN1, midasin 
                 MDN1 
                 2.3E−04 
                 2.1 
                 9.3E−04 
               
               
                   
                   
                 homolog (yeast) 
               
               
                 201741_x_at 
                 M69040 
                 splicing factor, 
                 SFRS1 
                 2.4E−07 
                 2.1 
                 7.8E−05 
               
               
                   
                   
                 arginine/serine-rich 1 
               
               
                   
                   
                 (splicing factor 2, 
               
               
                   
                   
                 alternate splicing 
               
               
                   
                   
                 factor) 
               
               
                 208644_at 
                 M32721 
                 poly (ADP-ribose) 
                 PARP1 
                 2.0E−05 
                 2.0 
                 1.3E−04 
               
               
                   
                   
                 polymerase family, 
               
               
                   
                   
                 member 1 
               
               
                 218306_s_at 
                 NM_003922 
                 hect (homologous to 
                 HERC1 
                 1.2E−05 
                 2.0 
                 1.0E−04 
               
               
                   
                   
                 the E6-AP (UBE3A) 
               
               
                   
                   
                 carboxyl terminus) 
               
               
                   
                   
                 domain and RCC1 
               
               
                   
                   
                 (CHC1)-like domain 
               
               
                   
                   
                 (RLD) 1 
               
               
                 213743_at 
                 BE674119 
                 cyclin T2 
                 CCNT2 
                 8.7E−07 
                 2.0 
                 4.2E−04 
               
               
                 208073_x_at 
                 NM_003316 
                 tetratricopeptide repeat 
                 TTC3 
                 1.6E−06 
                 2.0 
                 9.5E−04 
               
               
                   
                   
                 domain 3 
               
               
                 209043_at 
                 AF033026 
                 3′-phosphoadenosine 5′- 
                 PAPSS1 
                 6.6E−06 
                 2.0 
                 3.4E−05 
               
               
                   
                   
                 phosphosulfate 
               
               
                   
                   
                 synthase 1 
               
               
                 209715_at 
                 L07515 
                 chromobox homolog 5 
                 CBX5 
                 9.9E−05 
                 2.0 
                 3.1E−05 
               
               
                   
                   
                 (HP1 alpha homolog, 
               
               
                   
                   
                   Drosophila ) 
               
             
          
           
               
                 Genes higher expressed in the group of resistant cell 
               
               
                 lines 
               
             
          
           
               
                 209016_s_at 
                 BC002700 
                 keratin 7 
                 KRT7 
                 8.9E−05 
                 −81.0 
                 3.5E−06 
               
               
                 222108_at 
                 AC004010 
                 adhesion molecule 
                 AMIGO2 
                 1.0E−06 
                 −46.4 
                 1.6E−05 
               
               
                   
                   
                 with Ig-like domain 2 
               
               
                 209008_x_at 
                 U76549 
                 keratin 8 /// keratin 8 
                 KRT8 
                 1.1E−05 
                 −45.6 
                 2.5E−04 
               
               
                 202858_at 
                 NM_006758 
                 U2 small nuclear RNA 
                 U2AF1 
                 1.3E−08 
                 −42.3 
                 4.4E−06 
               
               
                   
                   
                 auxiliary factor 1 
               
               
                 204070_at 
                 NM_004585 
                 retinoic acid receptor 
                 RARRES3 
                 4.1E−04 
                 −40.9 
                 3.0E−05 
               
               
                   
                   
                 responder (tazarotene 
               
               
                   
                   
                 induced) 3 
               
               
                 201324_at 
                 NM_001423 
                 epithelial membrane 
                 EMP1 
                 6.9E−12 
                 −40.0 
                 3.4E−06 
               
               
                   
                   
                 protein 1 
               
               
                 211506_s_at 
                 AF043337 
                 interleukin 8 
                 IL8 
                 1.7E−06 
                 −39.6 
                 3.5E−05 
               
               
                 209835_x_at 
                 BC004372 
                 CD44 molecule 
                 CD44 
                 2.5E−11 
                 −38.7 
                 3.3E−06 
               
               
                   
                   
                 (Indian blood group) 
               
               
                 201858_s_at 
                 J03223 
                 proteoglycan 1, 
                 PRG1 
                 7.6E−07 
                 −37.9 
                 1.5E−04 
               
               
                   
                   
                 secretory granule 
               
               
                 202638_s_at 
                 NM_000201 
                 intercellular adhesion 
                 ICAM1 
                 1.8E−04 
                 −34.2 
                 2.6E−04 
               
               
                   
                   
                 molecule 1 (CD54), 
               
               
                   
                   
                 human rhinovirus 
               
               
                   
                   
                 receptor 
               
               
                 201596_x_at 
                 NM_000224 
                 keratin 18 
                 KRT18 
                 2.3E−07 
                 −33.3 
                 2.0E−05 
               
               
                 204855_at 
                 NM_002639 
                 serpin peptidase 
                 SERPINB5 
                 9.3E−04 
                 −30.4 
                 5.9E−05 
               
               
                   
                   
                 inhibitor, clade B 
               
               
                   
                   
                 (ovalbumin), member 5 
               
               
                 217901_at 
                 BF031829 
                 Desmoglein 2 
                 DSG2 
                 8.6E−05 
                 −30.2 
                 7.5E−04 
               
               
                 205083_at 
                 NM_001159 
                 aldehyde oxidase 1 
                 AOX1 
                 7.5E−07 
                 −28.3 
                 3.1E−05 
               
               
                 202855_s_at 
                 AL513917 
                 solute carrier family 
                 SLC16A3 
                 6.4E−08 
                 −25.5 
                 3.1E−06 
               
               
                   
                   
                 16, member 3 
               
               
                   
                   
                 (monocarboxylic acid 
               
               
                   
                   
                 transporter 4) 
               
               
                 215034_s_at 
                 AI189753 
                 transmembrane 4 L six 
                 TM4SF1 
                 2.5E−06 
                 −25.1 
                 1.1E−04 
               
               
                   
                   
                 family member 1 
               
               
                 221530_s_at 
                 BE857425 
                 basic helix-loop-helix 
                 BHLHB3 
                 1.1E−06 
                 −24.5 
                 3.6E−07 
               
               
                   
                   
                 domain containing, 
               
               
                   
                   
                 class B, 3 
               
               
                 202854_at 
                 NM_000194 
                 hypoxanthine 
                 HPRT1 
                 2.6E−08 
                 −24.1 
                 3.5E−06 
               
               
                   
                   
                 phosphoribosyltransferase 
               
               
                   
                   
                 1 (Lesch-Nyhan 
               
               
                   
                   
                 syndrome) 
               
               
                 201798_s_at 
                 NM_013451 
                 fer-1-like 3, myoferlin 
                 FER1L3 
                 2.4E−10 
                 −23.5 
                 2.5E−06 
               
               
                   
                   
                 ( C. elegans ) 
               
               
                 209803_s_at 
                 AF001294 
                 pleckstrin homology- 
                 PHLDA2 
                 2.2E−11 
                 −23.2 
                 3.3E−06 
               
               
                   
                   
                 like domain, family A, 
               
               
                   
                   
                 member 2 
               
               
                 210916_s_at 
                 AF098641 
                 CD44 molecule 
                 CD44 /// 
                 5.1E−11 
                 −21.7 
                 1.1E−05 
               
               
                   
                   
                 (Indian blood group) 
                 MAPK10 
               
               
                   
                   
                 /// mitogen-activated 
               
               
                   
                   
                 protein kinase 10 
               
               
                 203108_at 
                 NM_003979 
                 G protein-coupled 
                 GPRC5A 
                 5.8E−09 
                 −20.7 
                 1.3E−05 
               
               
                   
                   
                 receptor, family C, 
               
               
                   
                   
                 group 5, member A 
               
               
                 204420_at 
                 BG251266 
                 FOS-like antigen 1 
                 FOSL1 
                 6.7E−09 
                 −20.5 
                 4.7E−05 
               
               
                 206632_s_at 
                 NM_004900 
                 apolipoprotein B 
                 APOBEC3B 
                 3.2E−09 
                 −20.3 
                 1.5E−05 
               
               
                   
                   
                 mRNA editing 
               
               
                   
                   
                 enzyme, catalytic 
               
               
                   
                   
                 polypeptide-like 3B 
               
               
                 212444_at 
                 AA156240 
                 CDNA clone 
                 — 
                 1.2E−07 
                 −18.4 
                 1.0E−04 
               
               
                   
                   
                 IMAGE: 6025865 
               
               
                 204470_at 
                 NM_001511 
                 chemokine (C—X—C 
                 CXCL1 
                 1.1E−04 
                 −17.7 
                 2.8E−05 
               
               
                   
                   
                 motif) ligand 1 
               
               
                   
                   
                 (melanoma growth 
               
               
                   
                   
                 stimulating activity, 
               
               
                   
                   
                 alpha) 
               
               
                 201109_s_at 
                 AV726673 
                 thrombospondin 1 
                 THBS1 
                 4.0E−04 
                 −17.5 
                 9.9E−04 
               
               
                 205627_at 
                 NM_001785 
                 cytidine deaminase 
                 CDA 
                 5.9E−05 
                 −17.5 
                 5.4E−05 
               
               
                 209278_s_at 
                 L27624 
                 tissue factor pathway 
                 TFPI2 
                 3.3E−04 
                 −15.7 
                 4.7E−04 
               
               
                   
                   
                 inhibitor 2 
               
               
                 208747_s_at 
                 M18767 
                 complement 
                 C1S 
                 1.5E−04 
                 −15.3 
                 8.1E−04 
               
               
                   
                   
                 component 1, s 
               
               
                   
                   
                 subcomponent 
               
               
                 201842_s_at 
                 AI826799 
                 EGF-containing 
                 EFEMP1 
                 8.3E−04 
                 −14.0 
                 8.7E−04 
               
               
                   
                   
                 fibulin-like 
               
               
                   
                   
                 extracellular matrix 
               
               
                   
                   
                 protein 1 
               
               
                 210592_s_at 
                 M55580 
                 spermidine/spermine 
                 SAT1 
                 1.2E−08 
                 −13.9 
                 6.3E−06 
               
               
                   
                   
                 N1-acetyltransferase 1 
               
               
                 204222_s_at 
                 NM_006851 
                 GLI pathogenesis- 
                 GLIPR1 
                 2.6E−05 
                 −13.8 
                 5.6E−04 
               
               
                   
                   
                 related 1 (glioma) 
               
               
                 202627_s_at 
                 AL574210 
                 serpin peptidase 
                 SERPINE1 
                 1.6E−04 
                 −13.2 
                 6.7E−04 
               
               
                   
                   
                 inhibitor, clade E 
               
               
                   
                   
                 (nexin, plasminogen 
               
               
                   
                   
                 activator inhibitor type 
               
               
                   
                   
                 1), member 1 
               
               
                 203851_at 
                 NM_002178 
                 insulin-like growth 
                 IGFBP6 
                 1.8E−06 
                 −13.2 
                 3.0E−04 
               
               
                   
                   
                 factor binding protein 6 
               
               
                 208949_s_at 
                 BC001120 
                 lectin, galactoside- 
                 LGALS3 
                 2.3E−04 
                 −13.1 
                 6.4E−04 
               
               
                   
                   
                 binding, soluble, 3 
               
               
                   
                   
                 (galectin 3) 
               
               
                 210042_s_at 
                 AF073890 
                 cathepsin Z 
                 CTSZ 
                 3.0E−07 
                 −12.9 
                 2.1E−05 
               
               
                 206513_at 
                 NM_004833 
                 absent in melanoma 2 
                 AIM2 
                 1.1E−04 
                 −12.6 
                 1.9E−04 
               
               
                 202202_s_at 
                 NM_002290 
                 laminin, alpha 4 
                 LAMA4 
                 2.5E−05 
                 −12.2 
                 8.0E−04 
               
               
                 204363_at 
                 NM_001993 
                 coagulation factor III 
                 F3 
                 3.0E−04 
                 −11.9 
                 5.4E−04 
               
               
                   
                   
                 (thromboplastin, tissue 
               
               
                   
                   
                 factor) 
               
               
                 202832_at 
                 NM_014635 
                 GRIP and coiled-coil 
                 GCC2 
                 6.1E−04 
                 −11.9 
                 5.5E−05 
               
               
                   
                   
                 domain containing 2 
               
               
                 202267_at 
                 NM_005562 
                 laminin, gamma 2 
                 LAMC2 
                 3.7E−04 
                 −11.7 
                 1.6E−04 
               
               
                 219759_at 
                 NM_022350 
                 leukocyte-derived 
                 LRAP 
                 1.2E−06 
                 −11.6 
                 1.5E−05 
               
               
                   
                   
                 arginine 
               
               
                   
                   
                 aminopeptidase 
               
               
                 217744_s_at 
                 NM_022121 
                 PERP, TP53 apoptosis 
                 PERP 
                 1.0E−06 
                 −11.4 
                 4.0E−05 
               
               
                   
                   
                 effector 
               
               
                 204279_at 
                 NM_002800 
                 proteasome (prosome, 
                 PSMB9 
                 1.3E−05 
                 −11.2 
                 8.0E−06 
               
               
                   
                   
                 macropain) subunit, 
               
               
                   
                   
                 beta type, 9 (large 
               
               
                   
                   
                 multifunctional 
               
               
                   
                   
                 peptidase 2) 
               
               
                 201474_s_at 
                 NM_002204 
                 integrin, alpha 3 
                 ITGA3 
                 2.2E−08 
                 −11.1 
                 3.3E−07 
               
               
                   
                   
                 (antigen CD49C, alpha 
               
               
                   
                   
                 3 subunit of VLA-3 
               
               
                   
                   
                 receptor) 
               
               
                 201468_s_at 
                 NM_000903 
                 NAD(P)H 
                 NQO1 
                 3.8E−05 
                 −10.8 
                 2.4E−05 
               
               
                   
                   
                 dehydrogenase, 
               
               
                   
                   
                 quinone 1 
               
               
                 205798_at 
                 NM_002185 
                 interleukin 7 receptor 
                 IL7R 
                 3.2E−07 
                 −10.7 
                 7.5E−04 
               
               
                   
                   
                 /// interleukin 7 
               
               
                   
                   
                 receptor 
               
               
                 221059_s_at 
                 NM_021615 
                 coactosin-like 1 
                 COTL1 
                 3.8E−09 
                 −10.5 
                 2.5E−06 
               
               
                   
                   
                 (Dictyostelium) 
               
               
                 218211_s_at 
                 NM_024101 
                 melanophilin 
                 MLPH 
                 6.2E−06 
                 −10.4 
                 6.7E−05 
               
               
                 201042_at 
                 AL031651 
                 transglutaminase 2 (C 
                 TGM2 
                 1.4E−04 
                 −10.1 
                 6.7E−04 
               
               
                   
                   
                 polypeptide, protein- 
               
               
                   
                   
                 glutamine-gamma- 
               
               
                   
                   
                 glutamyltransferase) 
               
               
                 212473_s_at 
                 BE965029 
                 microtubule associated 
                 MICAL2 
                 1.8E−05 
                 −10.1 
                 9.7E−04 
               
               
                   
                   
                 monoxygenase, 
               
               
                   
                   
                 calponin and LIM 
               
               
                   
                   
                 domain containing 2 
               
               
                 201631_s_at 
                 NM_003897 
                 immediate early 
                 IER3 
                 1.9E−06 
                 −9.3 
                 4.3E−05 
               
               
                   
                   
                 response 3 
               
               
                 210896_s_at 
                 AF306765 
                 aspartate beta- 
                 ASPH 
                 9.8E−08 
                 −9.2 
                 1.4E−04 
               
               
                   
                   
                 hydroxylase 
               
               
                 208581_x_at 
                 NM_005952 
                 metallothionein 1X 
                 MT1X 
                 3.8E−06 
                 −8.9 
                 1.9E−04 
               
               
                 214446_at 
                 NM_012081 
                 elongation factor, 
                 ELL2 
                 4.9E−10 
                 −8.7 
                 3.2E−05 
               
               
                   
                   
                 RNA polymerase II, 2 
               
               
                 201170_s_at 
                 NM_003670 
                 basic helix-loop-helix 
                 BHLHB2 
                 2.5E−07 
                 −8.5 
                 3.5E−06 
               
               
                   
                   
                 domain containing, 
               
               
                   
                   
                 class B, 2 
               
               
                 202862_at 
                 NM_000137 
                 fumarylacetoacetate 
                 FAH 
                 4.0E−07 
                 −8.5 
                 1.6E−05 
               
               
                   
                   
                 hydrolase 
               
               
                   
                   
                 (fumarylacetoacetase) 
               
               
                 203234_at 
                 NM_003364 
                 uridine phosphorylase 1 
                 UPP1 
                 1.7E−06 
                 −8.5 
                 2.2E−05 
               
               
                 218322_s_at 
                 NM_016234 
                 acyl-CoA synthetase 
                 ACSL5 
                 9.4E−05 
                 −8.3 
                 1.9E−06 
               
               
                   
                   
                 long-chain family 
               
               
                   
                   
                 member 5 
               
               
                 206461_x_at 
                 NM_005951 
                 metallothionein 1H 
                 MT1H 
                 1.1E−06 
                 −8.2 
                 8.6E−05 
               
               
                 212185_x_at 
                 NM_005953 
                 metallothionein 2A 
                 MT2A 
                 1.4E−06 
                 −8.1 
                 1.9E−04 
               
               
                 208790_s_at 
                 AF312393 
                 polymerase I and 
                 PTRF 
                 3.4E−05 
                 −7.8 
                 8.7E−04 
               
               
                   
                   
                 transcript release 
               
               
                   
                   
                 factor 
               
               
                 36711_at 
                 AL021977 
                 v-maf 
                 MAFF 
                 7.4E−09 
                 −7.7 
                 9.7E−07 
               
               
                   
                   
                 musculoaponeurotic 
               
               
                   
                   
                 fibrosarcoma 
               
               
                   
                   
                 oncogene homolog F 
               
               
                   
                   
                 (avian) 
               
               
                 218084_x_at 
                 NM_014164 
                 FXYD domain 
                 FXYD5 
                 5.2E−06 
                 −7.6 
                 5.1E−06 
               
               
                   
                   
                 containing ion 
               
               
                   
                   
                 transport regulator 5 
               
               
                 217996_at 
                 AA576961 
                 pleckstrin homology- 
                 PHLDA1 
                 3.8E−07 
                 −7.5 
                 2.5E−04 
               
               
                   
                   
                 like domain, family A, 
               
               
                   
                   
                 member 1 
               
               
                 211456_x_at 
                 AF333388 
                 metallothionein 1H- 
                 LOC645745 
                 1.3E−06 
                 −7.4 
                 1.1E−04 
               
               
                   
                   
                 like protein 
               
               
                 213865_at 
                 AI378788 
                 discoidin, CUB and 
                 DCBLD2 
                 2.3E−07 
                 −7.4 
                 5.7E−04 
               
               
                   
                   
                 LCCL domain 
               
               
                   
                   
                 containing 2 
               
               
                 209514_s_at 
                 BE502030 
                 RAB27A, member 
                 RAB27A 
                 2.3E−05 
                 −7.3 
                 3.2E−04 
               
               
                   
                   
                 RAS oncogene family 
               
               
                 209310_s_at 
                 U25804 
                 caspase 4, apoptosis- 
                 CASP4 
                 1.4E−05 
                 −7.1 
                 1.3E−04 
               
               
                   
                   
                 related cysteine 
               
               
                   
                   
                 peptidase 
               
               
                 209040_s_at 
                 U17496 
                 proteasome (prosome, 
                 PSMB8 
                 1.8E−05 
                 −7.1 
                 6.9E−06 
               
               
                   
                   
                 macropain) subunit, 
               
               
                   
                   
                 beta type, 8 (large 
               
               
                   
                   
                 multifunctional 
               
               
                   
                   
                 peptidase 7) 
               
               
                 205100_at 
                 NM_005110 
                 glutamine-fructose-6- 
                 GFPT2 
                 3.3E−06 
                 −7.1 
                 2.1E−04 
               
               
                   
                   
                 phosphate 
               
               
                   
                   
                 transaminase 2 
               
               
                 213572_s_at 
                 AI554300 
                 serpin peptidase 
                 SERPINB1 
                 1.4E−07 
                 −7.0 
                 1.4E−07 
               
               
                   
                   
                 inhibitor, clade B 
               
               
                   
                   
                 (ovalbumin), member 1 
               
               
                 209679_s_at 
                 BC003379 
                 small trans-membrane 
                 LOC57228 
                 2.4E−06 
                 −7.0 
                 1.1E−04 
               
               
                   
                   
                 and glycosylated 
               
               
                   
                   
                 protein 
               
               
                 203821_at 
                 NM_001945 
                 heparin-binding EGF- 
                 HBEGF 
                 3.8E−05 
                 −6.9 
                 9.8E−05 
               
               
                   
                   
                 like growth factor 
               
               
                 220016_at 
                 NM_024060 
                 AHNAK 
                 AHNAK 
                 5.1E−05 
                 −6.9 
                 2.4E−05 
               
               
                   
                   
                 nucleoprotein 
               
               
                   
                   
                 (desmoyokin) 
               
               
                 212070_at 
                 AL554008 
                 G protein-coupled 
                 GPR56 
                 6.1E−05 
                 −6.8 
                 1.6E−07 
               
               
                   
                   
                 receptor 56 
               
               
                 211429_s_at 
                 AF119873 
                 serpin peptidase 
                 SERPINA1 
                 5.0E−04 
                 −6.8 
                 5.1E−05 
               
               
                   
                   
                 inhibitor, clade A 
               
               
                   
                   
                 (alpha-1 
               
               
                   
                   
                 antiproteinase, 
               
               
                   
                   
                 antitrypsin), member 1 
               
               
                 202863_at 
                 NM_003113 
                 SP100 nuclear antigen 
                 SP100 
                 1.7E−07 
                 −6.7 
                 1.4E−05 
               
               
                 216336_x_at 
                 AL031602 
                 metallothionein 1M 
                 MT1M 
                 5.3E−06 
                 −6.6 
                 1.3E−05 
               
               
                 217165_x_at 
                 M10943 
                 metallothionein 1F 
                 MT1F 
                 5.6E−06 
                 −6.6 
                 1.9E−04 
               
               
                   
                   
                 (functional) 
               
               
                 201983_s_at 
                 AW157070 
                 epidermal growth 
                 EGFR 
                 1.6E−06 
                 −6.5 
                 2.8E−04 
               
               
                   
                   
                 factor receptor 
               
               
                   
                   
                 (erythroblastic 
               
               
                   
                   
                 leukemia viral (v-erb- 
               
               
                   
                   
                 b) oncogene homolog, 
               
               
                   
                   
                 avian) 
               
               
                 210538_s_at 
                 U37546 
                 baculoviral IAP 
                 BIRC3 
                 1.6E−04 
                 −6.5 
                 5.4E−05 
               
               
                   
                   
                 repeat-containing 3 
               
               
                 201926_s_at 
                 BC001288 
                 CD55 molecule, decay 
                 CD55 
                 3.6E−06 
                 −6.5 
                 3.4E−04 
               
               
                   
                   
                 accelerating factor for 
               
               
                   
                   
                 complement (Cromer 
               
               
                   
                   
                 blood group) 
               
               
                 208944_at 
                 D50683 
                 transforming growth 
                 TGFBR2 
                 1.2E−06 
                 −6.5 
                 9.7E−04 
               
               
                   
                   
                 factor, beta receptor II 
               
               
                   
                   
                 (70/80 kDa) 
               
               
                 208690_s_at 
                 BC000915 
                 PDZ and LIM domain 
                 PDLIM1 
                 1.6E−04 
                 −6.4 
                 5.6E−05 
               
               
                   
                   
                 1 (elfin) 
               
               
                 210117_at 
                 AF311312 
                 sperm associated 
                 SPAG1 
                 3.6E−05 
                 −6.4 
                 4.2E−04 
               
               
                   
                   
                 antigen 1 
               
               
                 210138_at 
                 AF074979 
                 regulator of G-protein 
                 RGS20 
                 5.9E−06 
                 −6.3 
                 1.4E−05 
               
               
                   
                   
                 signalling 20 
               
               
                 217478_s_at 
                 X76775 
                 major 
                 HLA-DMA 
                 2.9E−04 
                 −6.2 
                 1.3E−04 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex, class II, DM 
               
               
                   
                   
                 alpha 
               
               
                 202499_s_at 
                 NM_006931 
                 solute carrier family 2 
                 SLC2A3 
                 1.1E−06 
                 −6.2 
                 2.0E−04 
               
               
                   
                   
                 (facilitated glucose 
               
               
                   
                   
                 transporter), member 3 
               
               
                 214791_at 
                 AK023116 
                 hypothetical protein 
                 LOC93349 
                 1.1E−06 
                 −6.1 
                 2.6E−06 
               
               
                   
                   
                 BC004921 
               
               
                 209457_at 
                 U16996 
                 dual specificity 
                 DUSP5 
                 1.5E−05 
                 −6.1 
                 1.7E−04 
               
               
                   
                   
                 phosphatase 5 
               
               
                 207574_s_at 
                 NM_015675 
                 growth arrest and 
                 GADD45B 
                 1.2E−06 
                 −6.0 
                 1.6E−04 
               
               
                   
                   
                 DNA-damage- 
               
               
                   
                   
                 inducible, beta 
               
               
                 214866_at 
                 X74039 
                 plasminogen activator, 
                 PLAUR 
                 8.1E−07 
                 −5.8 
                 3.8E−04 
               
               
                   
                   
                 urokinase receptor 
               
               
                 211612_s_at 
                 U62858 
                 interleukin 13 
                 IL13RA1 
                 1.5E−07 
                 −5.7 
                 1.1E−05 
               
               
                   
                   
                 receptor, alpha 1 /// 
               
               
                   
                   
                 interleukin 13 
               
               
                   
                   
                 receptor, alpha 1 
               
               
                 207265_s_at 
                 NM_016657 
                 KDEL (Lys-Asp-Glu- 
                 KDELR3 
                 1.4E−07 
                 −5.6 
                 5.0E−04 
               
               
                   
                   
                 Leu) endoplasmic 
               
               
                   
                   
                 reticulum protein 
               
               
                   
                   
                 retention receptor 3 
               
               
                 213274_s_at 
                 AA020826 
                 cathepsin B 
                 CTSB 
                 6.6E−05 
                 −5.6 
                 2.2E−04 
               
               
                 200632_s_at 
                 NM_006096 
                 N-myc downstream 
                 NDRG1 
                 5.2E−05 
                 −5.5 
                 2.1E−04 
               
               
                   
                   
                 regulated gene 1 
               
               
                 222150_s_at 
                 AK026747 
                 hypothetical protein 
                 LOC54103 
                 8.8E−07 
                 −5.5 
                 1.1E−06 
               
               
                   
                   
                 LOC54103 
               
               
                 210136_at 
                 AW070431 
                 myelin basic protein 
                 MBP 
                 1.8E−06 
                 −5.4 
                 5.9E−04 
               
               
                 216985_s_at 
                 AJ002077 
                 syntaxin 3 
                 STX3 
                 1.7E−06 
                 −5.4 
                 3.5E−06 
               
               
                 201412_at 
                 NM_014045 
                 low density 
                 LRP10 
                 3.9E−06 
                 −5.3 
                 1.2E−04 
               
               
                   
                   
                 lipoprotein receptor- 
               
               
                   
                   
                 related protein 10 
               
               
                 205579_at 
                 NM_000861 
                 histamine receptor H1 
                 HRH1 
                 1.0E−06 
                 −5.3 
                 9.3E−06 
               
               
                 202733_at 
                 NM_004199 
                 procollagen-proline, 2- 
                 P4HA2 
                 5.2E−04 
                 −5.3 
                 3.8E−04 
               
               
                   
                   
                 oxoglutarate 4- 
               
               
                   
                   
                 dioxygenase (proline 
               
               
                   
                   
                 4-hydroxylase), alpha 
               
               
                   
                   
                 polypeptide II 
               
               
                 210987_x_at 
                 M19267 
                 tropomyosin 1 (alpha) 
                 TPM1 
                 1.7E−04 
                 −5.2 
                 3.2E−04 
               
               
                 204032_at 
                 NM_003567 
                 breast cancer anti- 
                 BCAR3 
                 2.8E−06 
                 −5.1 
                 7.4E−04 
               
               
                   
                   
                 estrogen resistance 3 
               
               
                 209706_at 
                 AF247704 
                 NK3 transcription 
                 NKX3-1 
                 2.0E−05 
                 −5.1 
                 2.3E−05 
               
               
                   
                   
                 factor related, locus 1 
               
               
                   
                   
                 ( Drosophila ) 
               
               
                 205499_at 
                 NM_014467 
                 sushi-repeat- 
                 SRPX2 
                 6.7E−06 
                 −5.0 
                 1.2E−05 
               
               
                   
                   
                 containing protein, X- 
               
               
                   
                   
                 linked 2 
               
               
                 202085_at 
                 NM_004817 
                 tight junction protein 2 
                 TJP2 
                 9.4E−04 
                 −4.9 
                 5.0E−04 
               
               
                   
                   
                 (zona occludens 2) 
               
               
                 219620_x_at 
                 NM_017723 
                 hypothetical protein 
                 FLJ20245 
                 7.0E−07 
                 −4.9 
                 2.3E−04 
               
               
                   
                   
                 FLJ20245 
               
               
                 212923_s_at 
                 AK024828 
                 chromosome 6 open 
                 C6orf145 
                 2.4E−08 
                 −4.9 
                 6.1E−05 
               
               
                   
                   
                 reading frame 145 
               
               
                 212463_at 
                 BE379006 
                 CD59 molecule, 
                 CD59 
                 1.8E−07 
                 −4.8 
                 2.4E−04 
               
               
                   
                   
                 complement 
               
               
                   
                   
                 regulatory protein 
               
               
                 201506_at 
                 NM_000358 
                 transforming growth 
                 TGFBI 
                 1.9E−04 
                 −4.8 
                 6.6E−04 
               
               
                   
                   
                 factor, beta-induced, 
               
               
                   
                   
                 68 kDa 
               
               
                 202180_s_at 
                 NM_017458 
                 major vault protein 
                 MVP 
                 6.1E−05 
                 −4.7 
                 9.6E−05 
               
               
                 203726_s_at 
                 NM_000227 
                 laminin, alpha 3 
                 LAMA3 
                 9.8E−04 
                 −4.6 
                 6.6E−04 
               
               
                 212543_at 
                 U83115 
                 absent in melanoma 1 
                 AIM1 
                 4.0E−04 
                 −4.6 
                 1.4E−04 
               
               
                 205266_at 
                 NM_002309 
                 leukemia inhibitory 
                 LIF 
                 2.5E−07 
                 −4.6 
                 3.7E−06 
               
               
                   
                   
                 factor (cholinergic 
               
               
                   
                   
                 differentiation factor) 
               
               
                 203939_at 
                 NM_002526 
                 5′-nucleotidase, ecto 
                 NT5E 
                 8.0E−04 
                 −4.6 
                 6.7E−04 
               
               
                   
                   
                 (CD73) 
               
               
                 222294_s_at 
                 AW971415 
                 CDNA clone 
                 — 
                 4.1E−05 
                 −4.6 
                 1.2E−04 
               
               
                   
                   
                 IMAGE: 5745639 
               
               
                 206034_at 
                 NM_002640 
                 serpin peptidase 
                 SERPINB8 
                 5.9E−06 
                 −4.6 
                 5.9E−04 
               
               
                   
                   
                 inhibitor, clade B 
               
               
                   
                   
                 (ovalbumin), member 8 
               
               
                 214459_x_at 
                 M12679 
                 major 
                 HLA-C 
                 9.7E−04 
                 −4.6 
                 1.3E−04 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex, class I, C 
               
               
                 202990_at 
                 NM_002863 
                 phosphorylase, 
                 PYGL 
                 1.5E−05 
                 −4.6 
                 8.0E−04 
               
               
                   
                   
                 glycogen; liver (Hers 
               
               
                   
                   
                 disease, glycogen 
               
               
                   
                   
                 storage disease type 
               
               
                   
                   
                 VI) 
               
               
                 205896_at 
                 NM_003059 
                 solute carrier family 
                 SLC22A4 
                 2.3E−05 
                 −4.5 
                 1.8E−04 
               
               
                   
                   
                 22 (organic cation 
               
               
                   
                   
                 transporter), member 4 
               
               
                 203041_s_at 
                 J04183 
                 lysosomal-associated 
                 LAMP2 
                 1.2E−04 
                 −4.5 
                 2.7E−05 
               
               
                   
                   
                 membrane protein 2 
               
               
                 201471_s_at 
                 NM_003900 
                 sequestosome 1 
                 SQSTM1 
                 3.9E−06 
                 −4.5 
                 2.0E−04 
               
               
                 218631_at 
                 NM_021732 
                 arginine vasopressin- 
                 AVPI1 
                 2.9E−05 
                 −4.5 
                 3.1E−05 
               
               
                   
                   
                 induced 1 
               
               
                 204981_at 
                 NM_002555 
                 solute carrier family 
                 SLC22A18 
                 6.9E−06 
                 −4.5 
                 1.1E−04 
               
               
                   
                   
                 22 (organic cation 
               
               
                   
                   
                 transporter), member 
               
               
                   
                   
                 18 
               
               
                 203005_at 
                 NM_002342 
                 lymphotoxin beta 
                 LTBR 
                 2.5E−07 
                 −4.5 
                 2.8E−07 
               
               
                   
                   
                 receptor (TNFR 
               
               
                   
                   
                 superfamily, member 
               
               
                   
                   
                 3) 
               
               
                 200766_at 
                 NM_001909 
                 cathepsin D 
                 CTSD 
                 3.4E−05 
                 −4.4 
                 9.5E−06 
               
               
                 204745_x_at 
                 NM_005950 
                 metallothionein 1G 
                 MT1G 
                 4.0E−06 
                 −4.4 
                 2.8E−04 
               
               
                 219165_at 
                 NM_021630 
                 PDZ and LIM domain 
                 PDLIM2 
                 9.2E−06 
                 −4.3 
                 9.7E−04 
               
               
                   
                   
                 2 (mystique) 
               
               
                 201482_at 
                 NM_002826 
                 quiescin Q6 
                 QSCN6 
                 1.7E−05 
                 −4.3 
                 6.1E−05 
               
               
                 218368_s_at 
                 NM_016639 
                 tumor necrosis factor 
                 TNFRSF12A 
                 7.6E−07 
                 −4.2 
                 6.7E−05 
               
               
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                 member 12A 
               
               
                 209873_s_at 
                 AF053719 
                 plakophilin 3 
                 PKP3 
                 3.2E−04 
                 −4.2 
                 7.3E−05 
               
               
                 204254_s_at 
                 NM_000376 
                 vitamin D (1,25- 
                 VDR 
                 3.1E−05 
                 −4.2 
                 5.6E−06 
               
               
                   
                   
                 dihydroxyvitamin D3) 
               
               
                   
                   
                 receptor 
               
               
                 203430_at 
                 NM_014320 
                 heme binding protein 2 
                 HEBP2 
                 4.5E−05 
                 −4.2 
                 9.1E−05 
               
               
                 202531_at 
                 NM_002198 
                 interferon regulatory 
                 IRF1 
                 4.4E−05 
                 −4.1 
                 3.0E−05 
               
               
                   
                   
                 factor 1 
               
               
                 205398_s_at 
                 NM_005902 
                 SMAD family member 3 
                 SMAD3 
                 4.4E−06 
                 −4.1 
                 7.5E−04 
               
               
                 203518_at 
                 NM_000081 
                 lysosomal trafficking 
                 LYST 
                 5.2E−04 
                 −4.1 
                 2.4E−04 
               
               
                   
                   
                 regulator 
               
               
                 218273_s_at 
                 NM_018444 
                 protein phosphatase 
                 PPM2C 
                 8.3E−08 
                 −4.0 
                 2.1E−04 
               
               
                   
                   
                 2C, magnesium- 
               
               
                   
                   
                 dependent, catalytic 
               
               
                   
                   
                 subunit 
               
               
                 202087_s_at 
                 NM_001912 
                 cathepsin L 
                 CTSL 
                 9.0E−05 
                 −4.0 
                 1.6E−04 
               
               
                 218764_at 
                 NM_024064 
                 protein kinase C, eta 
                 PRKCH 
                 7.8E−05 
                 −3.9 
                 1.2E−05 
               
               
                 201422_at 
                 NM_006332 
                 interferon, gamma- 
                 IFI30 
                 7.7E−04 
                 −3.9 
                 2.7E−04 
               
               
                   
                   
                 inducible protein 30 
               
               
                 212196_at 
                 AW242916 
                 Interleukin 6 signal 
                 IL6ST 
                 4.5E−05 
                 −3.9 
                 8.0E−04 
               
               
                   
                   
                 transducer (gp130, 
               
               
                   
                   
                 oncostatin M receptor) 
               
               
                 202201_at 
                 NM_000713 
                 biliverdin reductase B 
                 BLVRB 
                 3.3E−05 
                 −3.8 
                 4.3E−06 
               
               
                   
                   
                 (flavin reductase 
               
               
                   
                   
                 (NADPH)) 
               
               
                 209417_s_at 
                 BC001356 
                 interferon-induced 
                 IFI35 
                 6.6E−05 
                 −3.8 
                 2.9E−04 
               
               
                   
                   
                 protein 35 
               
               
                 203329_at 
                 NM_002845 
                 protein tyrosine 
                 PTPRM 
                 3.9E−06 
                 −3.8 
                 5.8E−05 
               
               
                   
                   
                 phosphatase, receptor 
               
               
                   
                   
                 type, M 
               
               
                 200701_at 
                 NM_006432 
                 Niemann-Pick disease, 
                 NPC2 
                 1.2E−04 
                 −3.7 
                 8.2E−04 
               
               
                   
                   
                 type C2 
               
               
                 219622_at 
                 NM_017817 
                 RAB20, member RAS 
                 RAB20 
                 8.5E−04 
                 −3.7 
                 8.7E−04 
               
               
                   
                   
                 oncogene family 
               
               
                 207467_x_at 
                 NM_001750 
                 calpastatin 
                 CAST 
                 6.6E−06 
                 −3.6 
                 4.1E−04 
               
               
                 205640_at 
                 NM_000694 
                 aldehyde 
                 ALDH3B1 
                 7.4E−07 
                 −3.6 
                 1.5E−07 
               
               
                   
                   
                 dehydrogenase 3 
               
               
                   
                   
                 family, member B1 
               
               
                 203215_s_at 
                 AA877789 
                 myosin VI 
                 MYO6 
                 9.1E−04 
                 −3.5 
                 4.0E−05 
               
               
                 217998_at 
                 NM_007350 
                 pleckstrin homology- 
                 PHLDA1 /// 
                 4.5E−07 
                 −3.4 
                 2.1E−04 
               
               
                   
                   
                 like domain, family A, 
                 LOC652993 
               
               
                   
                   
                 member 1 /// 
               
               
                   
                   
                 hypothetical 
               
               
                   
                   
                 LOC652993 
               
               
                 204158_s_at 
                 NM_006019 
                 T-cell, immune 
                 TCIRG1 
                 5.4E−05 
                 −3.4 
                 7.5E−04 
               
               
                   
                   
                 regulator 1, ATPase, 
               
               
                   
                   
                 H+ transporting, 
               
               
                   
                   
                 lysosomal V0 subunit 
               
               
                   
                   
                 A3 
               
               
                 208637_x_at 
                 BC003576 
                 actinin, alpha 1 
                 ACTN1 
                 1.2E−07 
                 −3.4 
                 4.4E−05 
               
               
                 218844_at 
                 NM_025149 
                 hypothetical protein 
                 FLJ20920 
                 1.5E−04 
                 −3.4 
                 8.3E−05 
               
               
                   
                   
                 FLJ20920 
               
               
                 219716_at 
                 NM_030641 
                 apolipoprotein L, 6 
                 APOL6 
                 1.4E−05 
                 −3.4 
                 2.2E−08 
               
               
                 204747_at 
                 NM_001549 
                 interferon-induced 
                 IFIT3 
                 1.7E−06 
                 −3.4 
                 4.2E−04 
               
               
                   
                   
                 protein with 
               
               
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                 repeats 3 
               
               
                 202693_s_at 
                 AW194730 
                 serine/threonine kinase 
                 STK17A 
                 1.6E−04 
                 −3.3 
                 6.4E−04 
               
               
                   
                   
                 17a (apoptosis- 
               
               
                   
                   
                 inducing) 
               
               
                 210276_s_at 
                 AF281030 
                 TRIO and F-actin 
                 TRIOBP 
                 2.5E−04 
                 −3.3 
                 3.4E−04 
               
               
                   
                   
                 binding protein 
               
               
                 205730_s_at 
                 NM_014945 
                 actin binding LIM 
                 ABLIM3 
                 3.2E−05 
                 −3.3 
                 1.2E−04 
               
               
                   
                   
                 protein family, 
               
               
                   
                   
                 member 3 
               
               
                 202861_at 
                 NM_002616 
                 period homolog 1 
                 PER1 
                 4.8E−05 
                 −3.3 
                 5.6E−05 
               
               
                   
                   
                 ( Drosophila ) 
               
               
                 217739_s_at 
                 NM_005746 
                 pre-B-cell colony 
                 PBEF1 
                 7.8E−06 
                 −3.3 
                 1.4E−04 
               
               
                   
                   
                 enhancing factor 1 
               
               
                 221044_s_at 
                 NM_021616 
                 tripartite motif- 
                 TRIM34 /// 
                 4.7E−06 
                 −3.3 
                 3.1E−04 
               
               
                   
                   
                 containing 34 /// 
                 TRIM6-TRIM34 
               
               
                   
                   
                 tripartite motif- 
               
               
                   
                   
                 containing 6 and 
               
               
                   
                   
                 tripartite motif- 
               
               
                   
                   
                 containing 34 
               
               
                 207375_s_at 
                 NM_002189 
                 interleukin 15 
                 IL15RA 
                 1.1E−05 
                 −3.3 
                 1.3E−04 
               
               
                   
                   
                 receptor, alpha 
               
               
                 213816_s_at 
                 AA005141 
                 met proto-oncogene 
                 MET 
                 1.8E−06 
                 −3.2 
                 9.9E−04 
               
               
                   
                   
                 (hepatocyte growth 
               
               
                   
                   
                 factor receptor) 
               
               
                 221843_s_at 
                 AA195017 
                 KIAA1609 
                 KIAA1609 
                 4.6E−05 
                 −3.2 
                 3.4E−05 
               
               
                 218983_at 
                 NM_016546 
                 complement 
                 C1RL 
                 3.6E−04 
                 −3.2 
                 3.1E−04 
               
               
                   
                   
                 component 1, r 
               
               
                   
                   
                 subcomponent-like 
               
               
                 207357_s_at 
                 NM_017540 
                 UDP-N-acetyl-alpha- 
                 GALNT10 
                 3.9E−06 
                 −3.2 
                 7.3E−05 
               
               
                   
                   
                 D- 
               
               
                   
                   
                 galactosamine:polypeptide 
               
               
                   
                   
                 N- 
               
               
                   
                   
                 acetylgalactosaminyltransferase 
               
               
                   
                   
                 10 (GalNAc- 
               
               
                   
                   
                 T10) 
               
               
                 218292_s_at 
                 NM_016203 
                 protein kinase, AMP- 
                 PRKAG2 
                 1.2E−06 
                 −3.2 
                 1.4E−04 
               
               
                   
                   
                 activated, gamma 2 
               
               
                   
                   
                 non-catalytic subunit 
               
               
                 207643_s_at 
                 NM_001065 
                 tumor necrosis factor 
                 TNFRSF1A 
                 1.5E−05 
                 −3.2 
                 2.6E−04 
               
               
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                 member 1A 
               
               
                 204629_at 
                 NM_013327 
                 parvin, beta 
                 PARVB 
                 1.1E−04 
                 −3.1 
                 7.5E−04 
               
               
                 212552_at 
                 BE617588 
                 hippocalcin-like 1 
                 HPCAL1 
                 1.5E−04 
                 −3.1 
                 3.1E−04 
               
               
                 204682_at 
                 NM_000428 
                 latent transforming 
                 LTBP2 
                 1.1E−05 
                 −3.1 
                 4.0E−06 
               
               
                   
                   
                 growth factor beta 
               
               
                   
                   
                 binding protein 2 
               
               
                 219691_at 
                 NM_017654 
                 sterile alpha motif 
                 SAMD9 
                 6.1E−05 
                 −3.1 
                 3.5E−05 
               
               
                   
                   
                 domain containing 9 
               
               
                 200885_at 
                 NM_005167 
                 ras homolog gene 
                 RHOC 
                 1.6E−06 
                 −3.1 
                 2.0E−04 
               
               
                   
                   
                 family, member C 
               
               
                 212737_at 
                 AL513583 
                 GM2 ganglioside 
                 GM2A 
                 1.7E−05 
                 −3.0 
                 7.2E−06 
               
               
                   
                   
                 activator 
               
               
                 210514_x_at 
                 AF226990 
                 HLA-G 
                 HLA-G 
                 7.8E−04 
                 −3.0 
                 7.4E−04 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 antigen, class I, G 
               
               
                 201944_at 
                 NM_000521 
                 hexosaminidase B 
                 HEXB 
                 9.4E−07 
                 −2.9 
                 4.2E−04 
               
               
                   
                   
                 (beta polypeptide) 
               
               
                 218849_s_at 
                 NM_006663 
                 protein phosphatase 1, 
                 PPP1R13L 
                 4.5E−05 
                 −2.9 
                 2.4E−04 
               
               
                   
                   
                 regulatory (inhibitor) 
               
               
                   
                   
                 subunit 13 like 
               
               
                 204693_at 
                 NM_007061 
                 CDC42 effector 
                 CDC42EP1 
                 5.0E−05 
                 −2.9 
                 2.8E−04 
               
               
                   
                   
                 protein (Rho GTPase 
               
               
                   
                   
                 binding) 1 
               
               
                 209546_s_at 
                 AF323540 
                 apolipoprotein L, 1 
                 APOL1 
                 3.7E−06 
                 −2.9 
                 1.2E−05 
               
               
                 204034_at 
                 NM_014297 
                 ethylmalonic 
                 ETHE1 
                 3.8E−06 
                 −2.9 
                 4.2E−05 
               
               
                   
                   
                 encephalopathy 1 
               
               
                 202307_s_at 
                 NM_000593 
                 transporter 1, ATP- 
                 TAP1 
                 3.3E−04 
                 −2.9 
                 2.4E−04 
               
               
                   
                   
                 binding cassette, sub- 
               
               
                   
                   
                 family B (MDR/TAP) 
               
               
                 210978_s_at 
                 BC002616 
                 transgelin 2 
                 TAGLN2 
                 2.5E−04 
                 −2.9 
                 8.6E−05 
               
               
                 202275_at 
                 NM_000402 
                 glucose-6-phosphate 
                 G6PD 
                 3.7E−04 
                 −2.9 
                 3.0E−04 
               
               
                   
                   
                 dehydrogenase 
               
               
                 217150_s_at 
                 S73854 
                 neurofibromin 2 
                 NF2 
                 3.3E−05 
                 −2.9 
                 1.2E−04 
               
               
                   
                   
                 (bilateral acoustic 
               
               
                   
                   
                 neuroma) 
               
               
                 202545_at 
                 NM_006254 
                 protein kinase C, delta 
                 PRKCD 
                 1.5E−05 
                 −2.9 
                 7.9E−04 
               
               
                 214783_s_at 
                 BG177920 
                 annexin A11 
                 ANXA11 
                 7.0E−07 
                 −2.8 
                 6.2E−05 
               
               
                 214077_x_at 
                 H15129 
                 Meis1 homolog 3 
                 MEIS3P1 
                 7.1E−04 
                 −2.8 
                 9.5E−04 
               
               
                   
                   
                 (mouse) pseudogene 1 
               
               
                 213083_at 
                 AJ005866 
                 solute carrier family 
                 SLC35D2 
                 4.3E−04 
                 −2.8 
                 4.9E−04 
               
               
                   
                   
                 35, member D2 
               
               
                 220049_s_at 
                 NM_025239 
                 programmed cell death 
                 PDCD1LG2 
                 2.7E−04 
                 −2.8 
                 3.1E−05 
               
               
                   
                   
                 1 ligand 2 
               
               
                 211926_s_at 
                 AI827941 
                 myosin, heavy chain 9, 
                 MYH9 
                 1.6E−05 
                 −2.8 
                 6.2E−04 
               
               
                   
                   
                 non-muscle 
               
               
                 221291_at 
                 NM_025217 
                 UL16 binding protein 2 
                 ULBP2 
                 1.6E−04 
                 −2.8 
                 2.4E−04 
               
               
                 208613_s_at 
                 AV712733 
                 filamin B, beta (actin 
                 FLNB 
                 5.2E−04 
                 −2.7 
                 6.0E−04 
               
               
                   
                   
                 binding protein 278) 
               
               
                 218747_s_at 
                 NM_018009 
                 TAP binding protein- 
                 TAPBPL 
                 3.6E−04 
                 −2.7 
                 7.4E−05 
               
               
                   
                   
                 like 
               
               
                 219684_at 
                 NM_022147 
                 receptor 
                 RTP4 
                 1.4E−04 
                 −2.7 
                 8.0E−04 
               
               
                   
                   
                 (chemosensory) 
               
               
                   
                   
                 transporter protein 4 
               
               
                 206284_x_at 
                 NM_001834 
                 clathrin, light chain 
                 CLTB 
                 2.0E−04 
                 −2.6 
                 1.5E−06 
               
               
                   
                   
                 (Lcb) 
               
               
                 201847_at 
                 NM_000235 
                 lipase A, lysosomal 
                 LIPA 
                 3.7E−05 
                 −2.6 
                 9.1E−04 
               
               
                   
                   
                 acid, cholesterol 
               
               
                   
                   
                 esterase (Wolman 
               
               
                   
                   
                 disease) 
               
               
                 205192_at 
                 NM_003954 
                 mitogen-activated 
                 MAP3K14 
                 3.4E−05 
                 −2.6 
                 2.4E−04 
               
               
                   
                   
                 protein kinase kinase 
               
               
                   
                   
                 kinase 14 
               
               
                 221473_x_at 
                 U49188 
                 serine incorporator 3 
                 SERINC3 
                 1.5E−07 
                 −2.6 
                 6.7E−05 
               
               
                 218194_at 
                 NM_015523 
                 REX2, RNA 
                 REXO2 
                 8.9E−06 
                 −2.6 
                 6.6E−04 
               
               
                   
                   
                 exonuclease 2 
               
               
                   
                   
                 homolog ( S. cerevisiae ) 
               
               
                 205084_at 
                 NM_018844 
                 B-cell receptor- 
                 BCAP29 
                 2.8E−06 
                 −2.6 
                 4.9E−04 
               
               
                   
                   
                 associated protein 29 
               
               
                 202996_at 
                 NM_021173 
                 polymerase (DNA- 
                 POLD4 
                 6.3E−05 
                 −2.6 
                 5.3E−04 
               
               
                   
                   
                 directed), delta 4 
               
               
                 208872_s_at 
                 AA814140 
                 receptor accessory 
                 REEP5 
                 4.6E−05 
                 −2.6 
                 2.8E−04 
               
               
                   
                   
                 protein 5 
               
               
                 60471_at 
                 AA625133 
                 Ras and Rab interactor 3 
                 RIN3 
                 1.5E−05 
                 −2.6 
                 6.8E−05 
               
               
                 203925_at 
                 NM_002061 
                 glutamate-cysteine 
                 GCLM 
                 6.8E−05 
                 −2.5 
                 5.9E−06 
               
               
                   
                   
                 ligase, modifier 
               
               
                   
                   
                 subunit 
               
               
                 201587_s_at 
                 NM_001569 
                 interleukin-1 receptor- 
                 IRAK1 
                 1.1E−05 
                 −2.5 
                 8.4E−05 
               
               
                   
                   
                 associated kinase 1 
               
               
                 204769_s_at 
                 M74447 
                 transporter 2, ATP- 
                 TAP2 
                 9.5E−06 
                 −2.5 
                 9.6E−06 
               
               
                   
                   
                 binding cassette, sub- 
               
               
                   
                   
                 family B (MDR/TAP) 
               
               
                 201953_at 
                 NM_006384 
                 calcium and integrin 
                 CIB1 
                 2.1E−06 
                 −2.5 
                 5.0E−04 
               
               
                   
                   
                 binding 1 (calmyrin) 
               
               
                 215723_s_at 
                 AJ276230 
                 phospholipase D1, 
                 PLD1 
                 8.6E−06 
                 −2.5 
                 4.7E−05 
               
               
                   
                   
                 phosphatidylcholine- 
               
               
                   
                   
                 specific 
               
               
                 205032_at 
                 NM_002203 
                 integrin, alpha 2 
                 ITGA2 
                 6.5E−04 
                 −2.5 
                 7.1E−04 
               
               
                   
                   
                 (CD49B, alpha 2 
               
               
                   
                   
                 subunit of VLA-2 
               
               
                   
                   
                 receptor) 
               
               
                 203045_at 
                 NM_004148 
                 ninjurin 1 
                 NINJ1 
                 2.9E−05 
                 −2.5 
                 4.0E−04 
               
               
                 221641_s_at 
                 AF241787 
                 acyl-CoA thioesterase 9 
                 ACOT9 
                 8.9E−05 
                 −2.5 
                 5.5E−04 
               
               
                 209039_x_at 
                 AF001434 
                 EH-domain containing 1 
                 EHD1 
                 5.2E−05 
                 −2.5 
                 8.8E−04 
               
               
                 209179_s_at 
                 BC003164 
                 leukocyte receptor 
                 LENG4 
                 3.1E−06 
                 −2.4 
                 1.5E−04 
               
               
                   
                   
                 cluster (LRC) member 4 
               
               
                 206670_s_at 
                 NM_013445 
                 glutamate 
                 GAD1 /// 
                 2.9E−04 
                 −2.4 
                 8.0E−04 
               
               
                   
                   
                 decarboxylase 1 
                 LASS6 
               
               
                   
                   
                 (brain, 67 kDa) /// 
               
               
                   
                   
                 LAG1 homolog, 
               
               
                   
                   
                 ceramide synthase 6 
               
               
                   
                   
                 ( S. cerevisiae ) 
               
               
                 201360_at 
                 NM_000099 
                 cystatin C (amyloid 
                 CST3 
                 5.6E−05 
                 −2.4 
                 7.7E−04 
               
               
                   
                   
                 angiopathy and 
               
               
                   
                   
                 cerebral hemorrhage) 
               
               
                 53720_at 
                 AI862559 
                 hypothetical protein 
                 FLJ11286 
                 3.2E−04 
                 −2.4 
                 4.4E−04 
               
               
                   
                   
                 FLJ11286 
               
               
                 201975_at 
                 NM_002956 
                 restin (Reed-Steinberg 
                 RSN 
                 1.4E−04 
                 −2.4 
                 3.7E−04 
               
               
                   
                   
                 cell-expressed 
               
               
                   
                   
                 intermediate filament- 
               
               
                   
                   
                 associated protein) 
               
               
                 200618_at 
                 NM_006148 
                 LIM and SH3 protein 1 
                 LASP1 
                 3.8E−05 
                 −2.4 
                 8.0E−04 
               
               
                 209575_at 
                 BC001903 
                 interleukin 10 
                 IL10RB 
                 4.2E−04 
                 −2.3 
                 9.6E−06 
               
               
                   
                   
                 receptor, beta 
               
               
                 220761_s_at 
                 NM_016281 
                 TAO kinase 3 
                 TAOK3 
                 3.7E−04 
                 −2.3 
                 5.2E−06 
               
               
                 208659_at 
                 AF034607 
                 chloride intracellular 
                 CLIC1 
                 1.9E−08 
                 −2.3 
                 4.1E−05 
               
               
                   
                   
                 channel 1 
               
               
                 213272_s_at 
                 AF070596 
                 transmembrane protein 
                 TMEM159 
                 2.0E−05 
                 −2.3 
                 1.1E−04 
               
               
                   
                   
                 159 
               
               
                 219710_at 
                 NM_024577 
                 SH3 domain and 
                 SH3TC2 
                 3.3E−04 
                 −2.3 
                 5.1E−05 
               
               
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                 repeats 2 
               
               
                 203258_at 
                 NM_006442 
                 DR1-associated 
                 DRAP1 
                 1.9E−05 
                 −2.3 
                 5.7E−04 
               
               
                   
                   
                 protein 1 (negative 
               
               
                   
                   
                 cofactor 2 alpha) 
               
               
                 221534_at 
                 AF073483 
                 chromosome 11 open 
                 C11orf68 
                 2.1E−04 
                 −2.3 
                 1.5E−04 
               
               
                   
                   
                 reading frame 68 
               
               
                 202122_s_at 
                 NM_005817 
                 mannose-6-phosphate 
                 M6PRBP1 
                 6.5E−07 
                 −2.3 
                 4.4E−04 
               
               
                   
                   
                 receptor binding 
               
               
                   
                   
                 protein 1 
               
               
                 202205_at 
                 NM_003370 
                 vasodilator-stimulated 
                 VASP 
                 7.5E−06 
                 −2.2 
                 1.6E−05 
               
               
                   
                   
                 phosphoprotein 
               
               
                 203920_at 
                 NM_005693 
                 nuclear receptor 
                 NR1H3 
                 3.6E−04 
                 −2.2 
                 5.5E−04 
               
               
                   
                   
                 subfamily 1, group H, 
               
               
                   
                   
                 member 3 
               
               
                 207196_s_at 
                 NM_006058 
                 TNFAIP3 interacting 
                 TNIP1 
                 1.1E−05 
                 −2.2 
                 4.1E−04 
               
               
                   
                   
                 protein 1 
               
               
                 218881_s_at 
                 NM_024530 
                 FOS-like antigen 2 
                 FOSL2 
                 1.1E−07 
                 −2.2 
                 1.8E−06 
               
               
                 204398_s_at 
                 NM_012155 
                 echinoderm 
                 EML2 
                 4.9E−05 
                 −2.2 
                 2.5E−06 
               
               
                   
                   
                 microtubule associated 
               
               
                   
                   
                 protein like 2 
               
               
                 202378_s_at 
                 NM_017526 
                 leptin receptor 
                 LEPROT 
                 3.7E−04 
                 −2.2 
                 1.3E−04 
               
               
                   
                   
                 overlapping transcript 
               
               
                 219332_at 
                 NM_024723 
                 MICAL-like 2 
                 MICALL2 
                 4.4E−05 
                 −2.2 
                 6.4E−04 
               
               
                 203454_s_at 
                 NM_004045 
                 ATX1 antioxidant 
                 ATOX1 
                 5.9E−06 
                 −2.2 
                 3.0E−04 
               
               
                   
                   
                 protein 1 homolog 
               
               
                   
                   
                 (yeast) 
               
               
                 208757_at 
                 BC001123 
                 transmembrane emp24 
                 TMED9 
                 7.9E−07 
                 −2.2 
                 8.7E−05 
               
               
                   
                   
                 protein transport 
               
               
                   
                   
                 domain containing 9 
               
               
                 209584_x_at 
                 AF165520 
                 apolipoprotein B 
                 APOBEC3C 
                 4.1E−05 
                 −2.2 
                 2.0E−04 
               
               
                   
                   
                 mRNA editing 
               
               
                   
                   
                 enzyme, catalytic 
               
               
                   
                   
                 polypeptide-like 3C 
               
               
                 220174_at 
                 NM_025061 
                 leucine rich repeat 
                 LRRC8E 
                 9.7E−05 
                 −2.2 
                 6.2E−04 
               
               
                   
                   
                 containing 8 family, 
               
               
                   
                   
                 member E 
               
               
                 200709_at 
                 NM_000801 
                 FK506 binding protein 
                 FKBP1A 
                 2.7E−06 
                 −2.2 
                 5.8E−05 
               
               
                   
                   
                 1A, 12 kDa 
               
               
                 215037_s_at 
                 U72398 
                 BCL2-like 1 
                 BCL2L1 
                 5.9E−04 
                 −2.2 
                 4.3E−04 
               
               
                 221926_s_at 
                 BF196320 
                 interleukin 17 receptor C 
                 IL17RC 
                 2.2E−06 
                 −2.2 
                 5.7E−06 
               
               
                 203279_at 
                 NM_014674 
                 ER degradation 
                 EDEM1 
                 8.4E−06 
                 −2.2 
                 5.7E−04 
               
               
                   
                   
                 enhancer, mannosidase 
               
               
                   
                   
                 alpha-like 1 
               
               
                 218109_s_at 
                 NM_022736 
                 major facilitator 
                 MFSD1 
                 1.7E−04 
                 −2.2 
                 1.5E−04 
               
               
                   
                   
                 superfamily domain 
               
               
                   
                   
                 containing 1 
               
               
                 221561_at 
                 L21934 
                 sterol O- 
                 SOAT1 
                 5.8E−05 
                 −2.2 
                 8.8E−04 
               
               
                   
                   
                 acyltransferase (acyl- 
               
               
                   
                   
                 Coenzyme A: 
               
               
                   
                   
                 cholesterol 
               
               
                   
                   
                 acyltransferase) 1 
               
               
                 214703_s_at 
                 AW954107 
                 mannosidase, alpha, 
                 MAN2B2 
                 2.4E−04 
                 −2.1 
                 9.9E−04 
               
               
                   
                   
                 class 2B, member 2 
               
               
                 202377_at 
                 AW026535 
                 — 
                 — 
                 1.5E−04 
                 −2.1 
                 7.5E−05 
               
               
                 202908_at 
                 NM_006005 
                 Wolfram syndrome 1 
                 WFS1 
                 7.7E−05 
                 −2.1 
                 5.1E−04 
               
               
                   
                   
                 (wolframin) 
               
               
                 40420_at 
                 AB015718 
                 serine/threonine kinase 
                 STK10 
                 1.6E−07 
                 −2.1 
                 1.1E−04 
               
               
                   
                   
                 10 
               
               
                 209940_at 
                 AF083068 
                 poly (ADP-ribose) 
                 PARP3 
                 7.4E−06 
                 −2.1 
                 1.7E−04 
               
               
                   
                   
                 polymerase family, 
               
               
                   
                   
                 member 3 
               
               
                 208701_at 
                 BC000373 
                 Amyloid beta (A4) 
                 APLP2 
                 1.2E−04 
                 −2.1 
                 8.5E−05 
               
               
                   
                   
                 precursor-like protein 2 
               
               
                 218065_s_at 
                 NM_020644 
                 TMEM9 domain 
                 TMEM9B 
                 6.5E−06 
                 −2.1 
                 1.3E−04 
               
               
                   
                   
                 family, member B 
               
               
                 204458_at 
                 AL110209 
                 lysophospholipase 3 
                 LYPLA3 
                 8.0E−05 
                 −2.1 
                 5.9E−04 
               
               
                   
                   
                 (lysosomal 
               
               
                   
                   
                 phospholipase A2) 
               
               
                 218749_s_at 
                 NM_024959 
                 solute carrier family 
                 SLC24A6 
                 2.0E−07 
                 −2.1 
                 2.1E−05 
               
               
                   
                   
                 24 
               
               
                   
                   
                 (sodium/potassium/calcium 
               
               
                   
                   
                 exchanger), 
               
               
                   
                   
                 member 6 
               
               
                 220189_s_at 
                 NM_014275 
                 mannosyl (alpha-1,3-)- 
                 MGAT4B 
                 7.0E−05 
                 −2.1 
                 1.4E−04 
               
               
                   
                   
                 glycoprotein beta-1,4- 
               
               
                   
                   
                 N- 
               
               
                   
                   
                 acetylglucosaminyltransferase, 
               
               
                   
                   
                 isozyme B 
               
               
                 218498_s_at 
                 NM_014584 
                 ERO1-like ( S. cerevisiae ) 
                 ERO1L 
                 1.5E−06 
                 −2.1 
                 8.2E−05 
               
               
                 201022_s_at 
                 NM_006870 
                 destrin (actin 
                 DSTN 
                 5.2E−06 
                 −2.1 
                 3.3E−06 
               
               
                   
                   
                 depolymerizing factor) 
               
               
                 208407_s_at 
                 NM_001331 
                 catenin (cadherin- 
                 CTNND1 
                 4.0E−04 
                 −2.1 
                 7.8E−04 
               
               
                   
                   
                 associated protein), 
               
               
                   
                   
                 delta 1 
               
               
                 336_at 
                 D38081 
                 thromboxane A2 
                 TBXA2R 
                 4.7E−04 
                 −2.0 
                 8.4E−05 
               
               
                   
                   
                 receptor 
               
               
                 221087_s_at 
                 NM_014349 
                 apolipoprotein L, 3 
                 APOL3 
                 1.5E−04 
                 −2.0 
                 2.1E−05 
               
               
                 218154_at 
                 NM_024736 
                 gasdermin domain 
                 GSDMDC1 
                 9.5E−06 
                 −2.0 
                 1.3E−04 
               
               
                   
                   
                 containing 1 
               
               
                   
               
               
                 The genes were selected by two statistic analyses: t-test (p &lt; 0.001 and 2 fold between the groups of 16 sensitive cell lines and 12 resistant cell lines) and the Pearson correlations between the log2 (IC 50 ) data and the expression level of each gene in the 28 cell lines (p &lt; 0.001). 
               
               
                 The overlapped genes listed here with p values and fold change indicated. 
               
               
                 The genes are rank ordered by the fold changes. 
               
               
                 The positive fold changes indicate the genes have higher expression level in the sensitive cell lines and the negative fold changes indicate the genes have higher expression level in the resistant cell lines. 
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
             
           
               
                 **TABLE 3 
               
             
             
               
                   
               
               
                 Genes correlated with the sensitivity of 29 sarcoma cell lines to 
               
               
                 compound 2 as identified by Affymetrix gene array. 
               
             
          
           
               
                   
                   
                   
                 Gene 
                 p-value 
                 Fold 
                 p-value 
               
               
                 probe 
                 Accession # 
                 Gene Title 
                 Symbol 
                 in t-test 
                 (S/R) 
                 (correlation) 
               
               
                   
               
             
          
           
               
                 Genes higher expressed in the group of sensitive 
               
               
                 cell lines 
               
             
          
           
               
                 214451_at 
                 NM_003221 
                 transcription 
                 TFAP2B 
                 7.2E−05 
                 18.4 
                 2.3E−04 
               
               
                   
                   
                 factor AP-2 beta 
                   
                   
                   
                   
               
               
                   
                   
                 (activating 
                   
                   
                   
                   
               
               
                   
                   
                 enhancer 
                   
                   
                   
                   
               
               
                   
                   
                 binding protein 
                   
                   
                   
                   
               
               
                   
                   
                 2 beta) 
                   
                   
                   
                   
               
               
                 216623_x_at 
                 AK025084 
                 trinucleotide 
                 TNRC9 
                 5.3E−04 
                 15.1 
                 3.0E−05 
               
               
                   
                   
                 repeat 
                   
                   
                   
                   
               
               
                   
                   
                 containing 9 
                   
                   
                   
                   
               
               
                 219740_at 
                 NM_024749 
                 vasohibin 2 
                 VASH2 
                 2.8E−04 
                 10.4 
                 4.7E−04 
               
               
                 211341_at 
                 L20433 
                 POU domain, 
                 POU4F1 
                 6.8E−04 
                 9.5 
                 3.9E−05 
               
               
                   
                   
                 class 4, 
                   
                   
                   
                   
               
               
                   
                   
                 transcription 
                   
                   
                   
                   
               
               
                   
                   
                 factor 1 
                   
                   
                   
                   
               
               
                 212713_at 
                 R72286 
                 microfibrillar- 
                 MFAP4 
                 2.6E−04 
                 8.3 
                 5.8E−04 
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 protein 4 
                   
                   
                   
                   
               
               
                 206440_at 
                 NM_004664 
                 lin-7 homolog A 
                 LIN7A 
                 4.8E−04 
                 5.6 
                 3.3E−05 
               
               
                   
                   
                 ( C. elegans ) 
                   
                   
                   
                   
               
               
                 204914_s_at 
                 AW157202 
                 SRY (sex 
                 SOX11 
                 6.9E−05 
                 5.5 
                 5.5E−04 
               
               
                   
                   
                 determining 
                   
                   
                   
                   
               
               
                   
                   
                 region Y)-box 
                   
                   
                   
                   
               
               
                   
                   
                 11 
                   
                   
                   
                   
               
               
                 218824_at 
                 NM_018215 
                 hypothetical 
                 FLJ10781 
                 5.1E−05 
                 5.4 
                 7.6E−04 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                   
                   
                 FLJ10781 
                   
                   
                   
                   
               
               
                 204457_s_at 
                 NM_002048 
                 growth arrest- 
                 GAS1 
                 8.9E−04 
                 5.1 
                 4.9E−05 
               
               
                   
                   
                 specific 1 
                   
                   
                   
                   
               
               
                 215043_s_at 
                 X83301 
                 SMA3 /// SMA5 
                 SMA3 
                 7.9E−05 
                 4.8 
                 3.9E−05 
               
               
                   
                   
                   
                 /// 
                   
                   
                   
               
               
                   
                   
                   
                 SMA5 
                   
                   
                   
               
               
                 203139_at 
                 NM_004938 
                 death-associated 
                 DAPK1 
                 6.9E−05 
                 4.8 
                 9.6E−05 
               
               
                   
                   
                 protein kinase 1 
                   
                   
                   
                   
               
               
                 212599_at 
                 AK025298 
                 autism 
                 AUTS2 
                 1.5E−04 
                 4.7 
                 2.4E−04 
               
               
                   
                   
                 susceptibility 
                   
                   
                   
                   
               
               
                   
                   
                 candidate 2 
                   
                   
                   
                   
               
               
                 205888_s_at 
                 AI962693 
                 janus kinase and 
                 JAKMIP2 
                 2.6E−04 
                 4.7 
                 1.6E−06 
               
               
                   
                   
                 microtubule 
                 /// 
                   
                   
                   
               
               
                   
                   
                 interacting 
                 MYT1L 
                   
                   
                   
               
               
                   
                   
                 protein 2 /// 
                   
                   
                   
                   
               
               
                   
                   
                 myelin 
                   
                   
                   
                   
               
               
                   
                   
                 transcription 
                   
                   
                   
                   
               
               
                   
                   
                 factor 1-like 
                   
                   
                   
                   
               
               
                 206565_x_at 
                 NM_006780 
                 SMA3 
                 SMA3 
                 6.9E−05 
                 4.2 
                 1.5E−05 
               
               
                 207781_s_at 
                 NM_021998 
                 zinc finger 
                 ZNF711 
                 7.7E−06 
                 4.0 
                 9.7E−06 
               
               
                   
                   
                 protein 711 
                   
                   
                   
                   
               
               
                 204860_s_at 
                 AI817801 
                 NLR family, 
                 NAIP /// 
                 9.0E−04 
                 4.0 
                 2.5E−04 
               
               
                   
                   
                 apoptosis 
                 LOC728519 
                   
                   
                   
               
               
                   
                   
                 inhibitory 
                   
                   
                   
                   
               
               
                   
                   
                 protein /// 
                   
                   
                   
                   
               
               
                   
                   
                 similar to 
                   
                   
                   
                   
               
               
                   
                   
                 Baculoviral IAP 
                   
                   
                   
                   
               
               
                   
                   
                 repeat- 
                   
                   
                   
                   
               
               
                   
                   
                 containing 
                   
                   
                   
                   
               
               
                   
                   
                 protein 1 
                   
                   
                   
                   
               
               
                   
                   
                 (Neuronal 
                   
                   
                   
                   
               
               
                   
                   
                 apoptosis 
                   
                   
                   
                   
               
               
                   
                   
                 inhibitory 
                   
                   
                   
                   
               
               
                   
                   
                 protein) 
                   
                   
                   
                   
               
               
                 213657_s_at 
                 BE858194 
                 Zinc finger 
                 ZNF710 
                 1.7E−05 
                 4.0 
                 9.2E−04 
               
               
                   
                   
                 protein 710 /// 
                 /// 
                   
                   
                   
               
               
                   
                   
                 MRNA full 
                 DOCK4 
                   
                   
                   
               
               
                   
                   
                 length insert 
                   
                   
                   
                   
               
               
                   
                   
                 cDNA clone 
                   
                   
                   
                   
               
               
                   
                   
                 EUROIMAGE 
                   
                   
                   
                   
               
               
                   
                   
                 375854 /// 
                   
                   
                   
                   
               
               
                   
                   
                 Dedicator of 
                   
                   
                   
                   
               
               
                   
                   
                 cytokinesis 4 
                   
                   
                   
                   
               
               
                 213216_at 
                 AL537463 
                 OTU domain 
                 OTUD3 
                 8.5E−04 
                 3.9 
                 1.4E−05 
               
               
                   
                   
                 containing 3 
                   
                   
                   
                   
               
               
                 204165_at 
                 NM_003931 
                 WAS protein 
                 WASF1 
                 1.6E−04 
                 3.8 
                 1.6E−04 
               
               
                   
                   
                 family, member 1 
                   
                   
                   
                   
               
               
                 200884_at 
                 NM_001823 
                 creatine kinase, 
                 CKB 
                 9.4E−05 
                 3.6 
                 1.1E−04 
               
               
                   
                   
                 brain 
                   
                   
                   
                   
               
               
                 212847_at 
                 AL036840 
                 Far upstream 
                 FUBP1 
                 9.3E−06 
                 3.5 
                 7.4E−05 
               
               
                   
                   
                 element (FUSE) 
                   
                   
                   
                   
               
               
                   
                   
                 binding protein 1 
                   
                   
                   
                   
               
               
                 205889_s_at 
                 NM_014790 
                 janus kinase and 
                 JAKMIP2 
                 2.3E−04 
                 3.5 
                 9.4E−07 
               
               
                   
                   
                 microtubule 
                   
                   
                   
                   
               
               
                   
                   
                 interacting 
                   
                   
                   
                   
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                 213605_s_at 
                 AL049987 
                 Similar to Beta- 
                 LOC728411 
                 5.5E−04 
                 3.4 
                 1.2E−04 
               
               
                   
                   
                 glucuronidase 
                   
                   
                   
                   
               
               
                   
                   
                 precursor 
                   
                   
                   
                   
               
               
                 208998_at 
                 U94592 
                 uncoupling 
                 UCP2 
                 7.2E−04 
                 3.3 
                 6.5E−05 
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                   
                   
                 (mitochondrial, 
                   
                   
                   
                   
               
               
                   
                   
                 proton carrier) 
                   
                   
                   
                   
               
               
                 212731_at 
                 U79297 
                 ankyrin repeat 
                 ANKRD46 
                 5.0E−06 
                 3.2 
                 8.5E−06 
               
               
                   
                   
                 domain 46 
                   
                   
                   
                   
               
               
                 213058_at 
                 AL033538 
                 tetratricopeptide 
                 TTC28 
                 4.8E−05 
                 3.1 
                 5.0E−05 
               
               
                   
                   
                 repeat domain 
                   
                   
                   
                   
               
               
                   
                   
                 28 
                   
                   
                   
                   
               
               
                 204742_s_at 
                 NM_015032 
                 androgen- 
                 APRIN 
                 2.7E−04 
                 3.0 
                 7.4E−06 
               
               
                   
                   
                 induced 
                   
                   
                   
                   
               
               
                   
                   
                 proliferation 
                   
                   
                   
                   
               
               
                   
                   
                 inhibitor 
                   
                   
                   
                   
               
               
                 201449_at 
                 AL567227 
                 TIA1 cytotoxic 
                 TIA1 
                 5.5E−06 
                 3.0 
                 5.6E−05 
               
               
                   
                   
                 granule- 
                   
                   
                   
                   
               
               
                   
                   
                 associated RNA 
                   
                   
                   
                   
               
               
                   
                   
                 binding protein 
                   
                   
                   
                   
               
               
                 203117_s_at 
                 NM_014871 
                 ubiquitin 
                 USP52 
                 8.9E−05 
                 2.9 
                 6.5E−05 
               
               
                   
                   
                 specific 
                   
                   
                   
                   
               
               
                   
                   
                 peptidase 52 
                   
                   
                   
                   
               
               
                 37577_at 
                 U79256 
                 Rho GTPase 
                 ARHGAP19 
                 5.0E−04 
                 2.9 
                 3.0E−04 
               
               
                   
                   
                 activating 
                   
                   
                   
                   
               
               
                   
                   
                 protein 19 
                   
                   
                   
                   
               
               
                 213283_s_at 
                 BG285616 
                 sal-like 2 
                 SALL2 
                 4.1E−04 
                 2.9 
                 3.8E−04 
               
               
                   
                   
                 ( Drosophila ) 
                   
                   
                   
                   
               
               
                 200644_at 
                 NM_023009 
                 MARCKS-like 1 
                 MARCKSL1 
                 3.4E−04 
                 2.9 
                 4.3E−04 
               
               
                 210045_at 
                 AU151428 
                 isocitrate 
                 IDH2 
                 5.7E−07 
                 2.8 
                 4.8E−05 
               
               
                   
                   
                 dehydrogenase 2 
                   
                   
                   
                   
               
               
                   
                   
                 (NADP+), 
                   
                   
                   
                   
               
               
                   
                   
                 mitochondrial 
                   
                   
                   
                   
               
               
                 218457_s_at 
                 NM_022552 
                 DNA (cytosine- 
                 DNMT3A 
                 2.2E−06 
                 2.8 
                 1.2E−04 
               
               
                   
                   
                 5-)- 
                   
                   
                   
                   
               
               
                   
                   
                 methyltransferase 
                   
                   
                   
                   
               
               
                   
                   
                 3 alpha 
                   
                   
                   
                   
               
               
                 208986_at 
                 AL559478 
                 transcription 
                 TCF12 
                 1.6E−05 
                 2.8 
                 7.2E−07 
               
               
                   
                   
                 factor 12 
                   
                   
                   
                   
               
               
                   
                   
                 (HTF4, helix- 
                   
                   
                   
                   
               
               
                   
                   
                 loop-helix 
                   
                   
                   
                   
               
               
                   
                   
                 transcription 
                   
                   
                   
                   
               
               
                   
                   
                 factors 4) 
                   
                   
                   
                   
               
               
                 213891_s_at 
                 AI927067 
                 CDNA 
                 — 
                 4.0E−04 
                 2.7 
                 6.5E−04 
               
               
                   
                   
                 FLJ11918 fis, 
                   
                   
                   
                   
               
               
                   
                   
                 clone 
                   
                   
                   
                   
               
               
                   
                   
                 HEMBB1000272 
                   
                   
                   
                   
               
               
                 210882_s_at 
                 U04811 
                 trophinin 
                 TRO 
                 1.9E−04 
                 2.6 
                 9.5E−04 
               
               
                 218223_s_at 
                 NM_016274 
                 pleckstrin 
                 PLEKHO1 
                 1.3E−04 
                 2.6 
                 3.7E−06 
               
               
                   
                   
                 homology 
                   
                   
                   
                   
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing, 
                   
                   
                   
                   
               
               
                   
                   
                 family O 
                   
                   
                   
                   
               
               
                   
                   
                 member 1 
                   
                   
                   
                   
               
               
                 212547_at 
                 N34842 
                 FLJ35348 
                 FLJ35348 
                 2.4E−06 
                 2.6 
                 1.5E−05 
               
               
                 203825_at 
                 NM_007371 
                 bromodomain 
                 BRD3 
                 1.7E−06 
                 2.6 
                 6.7E−06 
               
               
                   
                   
                 containing 3 
                   
                   
                   
                   
               
               
                 212126_at 
                 BG391282 
                 CDNA clone 
                 — 
                 4.3E−05 
                 2.6 
                 2.1E−05 
               
               
                   
                   
                 IMAGE: 4842353 
                   
                   
                   
                   
               
               
                 206554_x_at 
                 NM_006515 
                 SET domain and 
                 SETMAR 
                 1.3E−04 
                 2.6 
                 1.9E−04 
               
               
                   
                   
                 mariner 
                   
                   
                   
                   
               
               
                   
                   
                 transposase 
                   
                   
                   
                   
               
               
                   
                   
                 fusion gene 
                   
                   
                   
                   
               
               
                 221261_x_at 
                 NM_030801 
                 melanoma 
                 MAGED4 
                 1.8E−04 
                 2.6 
                 6.8E−05 
               
               
                   
                   
                 antigen family 
                   
                   
                   
                   
               
               
                   
                   
                 D, 4 /// 
                   
                   
                   
                   
               
               
                   
                   
                 melanoma 
                   
                   
                   
                   
               
               
                   
                   
                 antigen family 
                   
                   
                   
                   
               
               
                   
                   
                 D, 4 
                   
                   
                   
                   
               
               
                 212386_at 
                 BF592782 
                 CDNA 
                 — 
                 4.8E−04 
                 2.6 
                 4.3E−04 
               
               
                   
                   
                 FLJ11918 fis, 
                   
                   
                   
                   
               
               
                   
                   
                 clone 
                   
                   
                   
                   
               
               
                   
                   
                 HEMBB1000272 
                   
                   
                   
                   
               
               
                 215599_at 
                 X83300 
                 SMA4 /// similar 
                 SMA4 
                 6.5E−04 
                 2.6 
                 1.5E−04 
               
               
                   
                   
                 to SMA4 
                 /// 
                   
                   
                   
               
               
                   
                   
                   
                 LOC730390 
                   
                   
                   
               
               
                 209715_at 
                 L07515 
                 chromobox 
                 CBX5 
                 1.2E−05 
                 2.6 
                 1.7E−06 
               
               
                   
                   
                 homolog 5 (HP1 
                   
                   
                   
                   
               
               
                   
                   
                 alpha homolog, 
                   
                   
                   
                   
               
               
                   
                   
                   Drosophila ) 
                   
                   
                   
                   
               
               
                 221260_s_at 
                 NM_030809 
                 chromosome 12 
                 C12orf22 
                 9.9E−04 
                 2.5 
                 1.7E−04 
               
               
                   
                   
                 open reading 
                   
                   
                   
                   
               
               
                   
                   
                 frame 22 /// 
                   
                   
                   
                   
               
               
                   
                   
                 chromosome 12 
                   
                   
                   
                   
               
               
                   
                   
                 open reading 
                   
                   
                   
                   
               
               
                   
                   
                 frame 22 
                   
                   
                   
                   
               
               
                 212966_at 
                 AL043112 
                 hypermethylated 
                 HIC2 
                 2.4E−04 
                 2.5 
                 7.4E−04 
               
               
                   
                   
                 in cancer 2 
                   
                   
                   
                   
               
               
                 215128_at 
                 AV704232 
                 CDNA 
                 — 
                 3.2E−04 
                 2.5 
                 5.8E−05 
               
               
                   
                   
                 FLJ11682 fis, 
                   
                   
                   
                   
               
               
                   
                   
                 clone 
                   
                   
                   
                   
               
               
                   
                   
                 HEMBA1004880 
                   
                   
                   
                   
               
               
                 212670_at 
                 AA479278 
                 elastin 
                 ELN 
                 2.1E−04 
                 2.4 
                 3.3E−04 
               
               
                   
                   
                 (supravalvular 
                   
                   
                   
                   
               
               
                   
                   
                 aortic stenosis, 
                   
                   
                   
                   
               
               
                   
                   
                 Williams- 
                   
                   
                   
                   
               
               
                   
                   
                 Beuren 
                   
                   
                   
                   
               
               
                   
                   
                 syndrome) 
                   
                   
                   
                   
               
               
                 203298_s_at 
                 NM_004973 
                 jumonji, AT rich 
                 JARID2 
                 1.5E−04 
                 2.4 
                 5.3E−05 
               
               
                   
                   
                 interactive 
                   
                   
                   
                   
               
               
                   
                   
                 domain 2 
                   
                   
                   
                   
               
               
                 220443_s_at 
                 NM_012476 
                 ventral anterior 
                 VAX2 
                 6.6E−05 
                 2.4 
                 7.2E−06 
               
               
                   
                   
                 homeobox 2 
                   
                   
                   
                   
               
               
                 204799_at 
                 NM_014838 
                 zinc finger, 
                 ZBED4 
                 1.6E−06 
                 2.4 
                 5.0E−04 
               
               
                   
                   
                 BED-type 
                   
                   
                   
                   
               
               
                   
                   
                 containing 4 
                   
                   
                   
                   
               
               
                 209153_s_at 
                 M31523 
                 transcription 
                 TCF3 
                 1.4E−04 
                 2.4 
                 1.8E−04 
               
               
                   
                   
                 factor 3 (E2A 
                   
                   
                   
                   
               
               
                   
                   
                 immunoglobulin 
                   
                   
                   
                   
               
               
                   
                   
                 enhancer 
                   
                   
                   
                   
               
               
                   
                   
                 binding factors 
                   
                   
                   
                   
               
               
                   
                   
                 E12/E47) 
                   
                   
                   
                   
               
               
                 203625_x_at 
                 BG105365 
                 melanoma cell 
                 MCAM 
                 7.4E−04 
                 2.4 
                 5.6E−05 
               
               
                   
                   
                 adhesion 
                   
                   
                   
                   
               
               
                   
                   
                 molecule 
                   
                   
                   
                   
               
               
                 213387_at 
                 AB033066 
                 ATPase family, 
                 ATAD2B 
                 2.0E−05 
                 2.3 
                 3.0E−05 
               
               
                   
                   
                 AAA domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 2B 
                   
                   
                   
                   
               
               
                 213694_at 
                 AW027347 
                 round spermatid 
                 RSBN1 
                 2.8E−04 
                 2.3 
                 6.5E−04 
               
               
                   
                   
                 basic protein 1 
                   
                   
                   
                   
               
               
                 203046_s_at 
                 NM_003920 
                 timeless 
                 TIMELESS 
                 1.2E−05 
                 2.3 
                 2.7E−07 
               
               
                   
                   
                 homolog 
                   
                   
                   
                   
               
               
                   
                   
                 ( Drosophila ) 
                   
                   
                   
                   
               
               
                 214877_at 
                 BE794663 
                 CDK5 
                 CDKAL1 
                 5.5E−05 
                 2.3 
                 9.2E−04 
               
               
                   
                   
                 regulatory 
                   
                   
                   
                   
               
               
                   
                   
                 subunit 
                   
                   
                   
                   
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 protein 1-like 1 
                   
                   
                   
                   
               
               
                 208838_at 
                 AB020636 
                 — 
                 — 
                 2.6E−04 
                 2.3 
                 8.3E−06 
               
               
                 213610_s_at 
                 BE326381 
                 kelch-like 23 
                 KLHL23 
                 7.7E−04 
                 2.3 
                 8.3E−04 
               
               
                   
                   
                 ( Drosophila ) 
                   
                   
                   
                   
               
               
                 221965_at 
                 AI990326 
                 M-phase 
                 MPHOSPH9 
                 5.8E−04 
                 2.3 
                 1.1E−04 
               
               
                   
                   
                 phosphoprotein 9 
                   
                   
                   
                   
               
               
                 203026_at 
                 NM_014872 
                 zinc finger and 
                 ZBTB5 
                 1.6E−06 
                 2.3 
                 2.9E−05 
               
               
                   
                   
                 BTB domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 5 
                   
                   
                   
                   
               
               
                 210555_s_at 
                 U85430 
                 nuclear factor of 
                 NFATC3 
                 5.7E−07 
                 2.3 
                 5.8E−06 
               
               
                   
                   
                 activated T- 
                   
                   
                   
                   
               
               
                   
                   
                 cells, 
                   
                   
                   
                   
               
               
                   
                   
                 cytoplasmic, 
                   
                   
                   
                   
               
               
                   
                   
                 calcineurin- 
                   
                   
                   
                   
               
               
                   
                   
                 dependent 3 
                   
                   
                   
                   
               
               
                 211929_at 
                 AA527502 
                 heterogeneous 
                 HNRPA3 
                 3.5E−04 
                 2.2 
                 6.2E−04 
               
               
                   
                   
                 nuclear 
                   
                   
                   
                   
               
               
                   
                   
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                 A3 
                   
                   
                   
                   
               
               
                 212704_at 
                 AI049962 
                 zinc finger, 
                 ZCCHC11 
                 2.9E−05 
                 2.2 
                 7.8E−06 
               
               
                   
                   
                 CCHC domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 11 
                   
                   
                   
                   
               
               
                 208664_s_at 
                 AU131711 
                 tetratricopeptide 
                 TTC3 
                 1.7E−05 
                 2.2 
                 4.7E−04 
               
               
                   
                   
                 repeat domain 3 
                   
                   
                   
                   
               
               
                 210649_s_at 
                 AF231056 
                 AT rich 
                 ARID1A 
                 9.6E−05 
                 2.2 
                 4.1E−07 
               
               
                   
                   
                 interactive 
                   
                   
                   
                   
               
               
                   
                   
                 domain 1A 
                   
                   
                   
                   
               
               
                   
                   
                 (SWI-like) 
                   
                   
                   
                   
               
               
                 204060_s_at 
                 NM_005044 
                 protein kinase, 
                 PRKX 
                 8.2E−04 
                 2.2 
                 1.4E−04 
               
               
                   
                   
                 X-linked /// 
                 /// 
                   
                   
                   
               
               
                   
                   
                 protein kinase, 
                 PRKY 
                   
                   
                   
               
               
                   
                   
                 Y-linked 
                   
                   
                   
                   
               
               
                 212153_at 
                 AB007930 
                 pogo 
                 POGZ 
                 6.5E−04 
                 2.2 
                 6.9E−04 
               
               
                   
                   
                 transposable 
                   
                   
                   
                   
               
               
                   
                   
                 element with 
                   
                   
                   
                   
               
               
                   
                   
                 ZNF domain 
                   
                   
                   
                   
               
               
                 221902_at 
                 AL567940 
                 G protein- 
                 GPR153 
                 5.3E−04 
                 2.2 
                 4.4E−04 
               
               
                   
                   
                 coupled receptor 
                   
                   
                   
                   
               
               
                   
                   
                 153 
                   
                   
                   
                   
               
               
                 213302_at 
                 AL044326 
                 phosphoribosylformylglycinamidine 
                 PFAS 
                 3.7E−04 
                 2.2 
                 4.1E−04 
               
               
                   
                   
                 synthase 
                   
                   
                   
                   
               
               
                   
                   
                 (FGAR 
                   
                   
                   
                   
               
               
                   
                   
                 amidotransferase) 
                   
                   
                   
                   
               
               
                 52975_at 
                 AA534894 
                 family with 
                 FAM125B 
                 7.3E−04 
                 2.1 
                 1.1E−04 
               
               
                   
                   
                 sequence 
                   
                   
                   
                   
               
               
                   
                   
                 similarity 125, 
                   
                   
                   
                   
               
               
                   
                   
                 member B 
                   
                   
                   
                   
               
               
                 212164_at 
                 AL522296 
                 transmembrane 
                 TMEM183A 
                 1.5E−04 
                 2.1 
                 4.2E−05 
               
               
                   
                   
                 protein 183A 
                   
                   
                   
                   
               
               
                 208990_s_at 
                 AF132362 
                 heterogeneous 
                 HNRPH3 
                 5.8E−07 
                 2.1 
                 7.7E−06 
               
               
                   
                   
                 nuclear 
                   
                   
                   
                   
               
               
                   
                   
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                 H3 (2H9) 
                   
                   
                   
                   
               
               
                 221883_at 
                 AA133342 
                 PBX/knotted 1 
                 PKNOX1 
                 3.0E−05 
                 2.1 
                 1.2E−04 
               
               
                   
                   
                 homeobox 1 
                   
                   
                   
                   
               
               
                 202540_s_at 
                 NM_000859 
                 3-hydroxy-3- 
                 HMGCR 
                 1.8E−04 
                 2.1 
                 3.1E−04 
               
               
                   
                   
                 methylglutaryl- 
                   
                   
                   
                   
               
               
                   
                   
                 Coenzyme A 
                   
                   
                   
                   
               
               
                   
                   
                 reductase 
                   
                   
                   
                   
               
               
                 217025_s_at 
                 AL110225 
                 drebrin 1 
                 DBN1 
                 2.3E−04 
                 2.1 
                 4.3E−05 
               
               
                 218683_at 
                 NM_021190 
                 polypyrimidine 
                 PTBP2 
                 1.9E−04 
                 2.1 
                 8.9E−05 
               
               
                   
                   
                 tract binding 
                   
                   
                   
                   
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                 210962_s_at 
                 AB019691 
                 A kinase 
                 AKAP9 
                 5.9E−05 
                 2.1 
                 2.1E−06 
               
               
                   
                   
                 (PRKA) anchor 
                   
                   
                   
                   
               
               
                   
                   
                 protein (yotiao) 9 
                   
                   
                   
                   
               
               
                 212482_at 
                 BF671894 
                 required for 
                 RMND5A 
                 3.8E−04 
                 2.1 
                 1.5E−04 
               
               
                   
                   
                 meiotic nuclear 
                   
                   
                   
                   
               
               
                   
                   
                 division 5 
                   
                   
                   
                   
               
               
                   
                   
                 homolog A ( S. cerevisiae ) 
                   
                   
                   
                   
               
               
                 212919_at 
                 AV715578 
                 DCP2 
                 DCP2 
                 2.0E−04 
                 2.1 
                 1.1E−04 
               
               
                   
                   
                 decapping 
                   
                   
                   
                   
               
               
                   
                   
                 enzyme 
                   
                   
                   
                   
               
               
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
                   
               
               
                 219800_s_at 
                 NM_024838 
                 — 
                 — 
                 5.5E−04 
                 2.1 
                 3.9E−04 
               
               
                 201741_x_at 
                 M69040 
                 splicing factor, 
                 SFRS1 
                 3.6E−06 
                 2.1 
                 1.4E−04 
               
               
                   
                   
                 arginine/serine- 
                   
                   
                   
                   
               
               
                   
                   
                 rich 1 (splicing 
                   
                   
                   
                   
               
               
                   
                   
                 factor 2, 
                   
                   
                   
                   
               
               
                   
                   
                 alternate 
                   
                   
                   
                   
               
               
                   
                   
                 splicing factor) 
                   
                   
                   
                   
               
               
                 218875_s_at 
                 NM_012177 
                 F-box protein 5 
                 FBXO5 
                 8.3E−04 
                 2.1 
                 6.8E−04 
               
               
                 212170_at 
                 BF447705 
                 RNA binding 
                 RBM12 
                 2.5E−04 
                 2.1 
                 6.4E−05 
               
               
                   
                   
                 motif protein 12 
                   
                   
                   
                   
               
               
                 214221_at 
                 AI825212 
                 Alstrom 
                 ALMS1 
                 5.9E−04 
                 2.1 
                 4.2E−05 
               
               
                   
                   
                 syndrome 1 
                   
                   
                   
                   
               
               
                 210473_s_at 
                 M37712 
                 G protein- 
                 GPR125 
                 1.8E−04 
                 2.1 
                 2.6E−04 
               
               
                   
                   
                 coupled receptor 
                   
                   
                   
                   
               
               
                   
                   
                 125 
                   
                   
                   
                   
               
               
                 208839_s_at 
                 AL136810 
                 cullin-associated 
                 CAND1 
                 4.8E−04 
                 2.1 
                 1.2E−05 
               
               
                   
                   
                 and neddylation- 
                   
                   
                   
                   
               
               
                   
                   
                 dissociated 1 
                   
                   
                   
                   
               
               
                 208644_at 
                 M32721 
                 poly (ADP- 
                 PARP1 
                 3.3E−04 
                 2.0 
                 6.2E−05 
               
               
                   
                   
                 ribose) 
                   
                   
                   
                   
               
               
                   
                   
                 polymerase 
                   
                   
                   
                   
               
               
                   
                   
                 family, member 1 
                   
                   
                   
                   
               
               
                 205256_at 
                 NM_014830 
                 zinc finger and 
                 ZBTB39 
                 1.5E−05 
                 2.0 
                 3.4E−06 
               
               
                   
                   
                 BTB domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 39 
                   
                   
                   
                   
               
               
                 202455_at 
                 NM_005474 
                 histone 
                 HDAC5 
                 4.1E−04 
                 2.0 
                 2.3E−05 
               
               
                   
                   
                 deacetylase 5 
                   
                   
                   
                   
               
               
                 213677_s_at 
                 BG434893 
                 PMS1 
                 PMS1 
                 7.1E−06 
                 2.0 
                 6.4E−05 
               
               
                   
                   
                 postmeiotic 
                   
                   
                   
                   
               
               
                   
                   
                 segregation 
                   
                   
                   
                   
               
               
                   
                   
                 increased 1 ( S. cerevisiae ) 
                   
                   
                   
                   
               
               
                 206128_at 
                 AI264306 
                 adrenergic, 
                 ADRA2C 
                 9.1E−04 
                 2.0 
                 3.0E−05 
               
               
                   
                   
                 alpha-2C-, 
                   
                   
                   
                   
               
               
                   
                   
                 receptor 
                   
                   
                   
                   
               
               
                 201833_at 
                 NM_001527 
                 histone 
                 HDAC2 
                 2.1E−06 
                 2.0 
                 7.8E−05 
               
               
                   
                   
                 deacetylase 2 
                   
                   
                   
                   
               
               
                 202051_s_at 
                 NM_005095 
                 zinc finger, 
                 ZMYM4 
                 2.8E−04 
                 2.0 
                 3.8E−04 
               
               
                   
                   
                 MYM-type 4 
                   
                   
                   
                   
               
               
                 204520_x_at 
                 NM_014577 
                 bromodomain 
                 BRD1 
                 7.5E−06 
                 2.0 
                 8.3E−04 
               
               
                   
                   
                 containing 1 
                   
                   
                   
                   
               
               
                 201235_s_at 
                 BG339064 
                 BTG family, 
                 BTG2 
                 9.3E−04 
                 2.0 
                 5.9E−04 
               
               
                   
                   
                 member 2 
                   
                   
                   
                   
               
             
          
           
               
                 Genes higher expressed in the group of resistant 
               
               
                 cell lines 
               
             
          
           
               
                 222108_at 
                 AC004010 
                 adhesion 
                 AMIGO2 
                 4.8E−05 
                 −40.9 
                 7.8E−05 
               
               
                   
                   
                 molecule with 
                   
                   
                   
                   
               
               
                   
                   
                 Ig-like domain 2 
                   
                   
                   
                   
               
               
                 209835_x_at 
                 BC004372 
                 CD44 molecule 
                 CD44 
                 1.3E−06 
                 −33.2 
                 5.0E−06 
               
               
                   
                   
                 (Indian blood 
                   
                   
                   
                   
               
               
                   
                   
                 group) 
                   
                   
                   
                   
               
               
                 201858_s_at 
                 J03223 
                 proteoglycan 1, 
                 PRG1 
                 3.0E−05 
                 −30.8 
                 2.6E−04 
               
               
                   
                   
                 secretory 
                   
                   
                   
                   
               
               
                   
                   
                 granule 
                   
                   
                   
                   
               
               
                 202638_s_at 
                 NM_000201 
                 intercellular 
                 ICAM1 
                 3.6E−04 
                 −30.3 
                 4.0E−04 
               
               
                   
                   
                 adhesion 
                   
                   
                   
                   
               
               
                   
                   
                 molecule 1 
                   
                   
                   
                   
               
               
                   
                   
                 (CD54), human 
                   
                   
                   
                   
               
               
                   
                   
                 rhinovirus 
                   
                   
                   
                   
               
               
                   
                   
                 receptor 
                   
                   
                   
                   
               
               
                 217901_at 
                 BF031829 
                 Desmoglein 2 
                 DSG2 
                 9.6E−04 
                 −25.6 
                 5.7E−04 
               
               
                 205083_at 
                 NM_001159 
                 aldehyde 
                 AOX1 
                 6.5E−05 
                 −24.1 
                 1.7E−04 
               
               
                   
                   
                 oxidase 1 
                   
                   
                   
                   
               
               
                 213010_at 
                 AI088622 
                 protein kinase 
                 PRKCDBP 
                 3.8E−04 
                 −21.8 
                 7.5E−04 
               
               
                   
                   
                 C, delta binding 
                   
                   
                   
                   
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                 202855_s_at 
                 AL513917 
                 solute carrier 
                 SLC16A3 
                 1.5E−05 
                 −21.5 
                 1.2E−05 
               
               
                   
                   
                 family 16, 
                   
                   
                   
                   
               
               
                   
                   
                 member 3 
                   
                   
                   
                   
               
               
                   
                   
                 (monocarboxylic 
                   
                   
                   
                   
               
               
                   
                   
                 acid 
                   
                   
                   
                   
               
               
                   
                   
                 transporter 4) 
                   
                   
                   
                   
               
               
                 202854_at 
                 NM_000194 
                 hypoxanthine 
                 HPRT1 
                 1.4E−05 
                 −20.0 
                 8.7E−06 
               
               
                   
                   
                 phosphoribosyltransferase 1 
                   
                   
                   
                   
               
               
                   
                   
                 (Lesch-Nyhan 
                   
                   
                   
                   
               
               
                   
                   
                 syndrome) 
                   
                   
                   
                   
               
               
                 215034_s_at 
                 AI189753 
                 transmembrane 
                 TM4SF1 
                 2.0E−04 
                 −20.0 
                 1.1E−04 
               
               
                   
                   
                 4 L six family 
                   
                   
                   
                   
               
               
                   
                   
                 member 1 
                   
                   
                   
                   
               
               
                 210916_s_at 
                 AF098641 
                 CD44 molecule 
                 CD44 
                 1.0E−06 
                 −18.7 
                 7.2E−06 
               
               
                   
                   
                 (Indian blood 
                 /// 
                   
                   
                   
               
               
                   
                   
                 group) /// 
                 MAPK10 
                   
                   
                   
               
               
                   
                   
                 mitogen- 
                   
                   
                   
                   
               
               
                   
                   
                 activated protein 
                   
                   
                   
                   
               
               
                   
                   
                 kinase 10 
                   
                   
                   
                   
               
               
                 221530_s_at 
                 BE857425 
                 basic helix-loop- 
                 BHLHB3 
                 3.5E−04 
                 −18.1 
                 4.7E−06 
               
               
                   
                   
                 helix domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing, class 
                   
                   
                   
                   
               
               
                   
                   
                 B, 3 
                   
                   
                   
                   
               
               
                 209803_s_at 
                 AF001294 
                 pleckstrin 
                 PHLDA2 
                 1.6E−06 
                 −17.4 
                 2.0E−06 
               
               
                   
                   
                 homology-like 
                   
                   
                   
                   
               
               
                   
                   
                 domain, family 
                   
                   
                   
                   
               
               
                   
                   
                 A, member 2 
                   
                   
                   
                   
               
               
                 204420_at 
                 BG251266 
                 FOS-like 
                 FOSL1 
                 1.6E−06 
                 −17.2 
                 9.8E−06 
               
               
                   
                   
                 antigen 1 
                   
                   
                   
                   
               
               
                 201596_x_at 
                 NM_000224 
                 keratin 18 
                 KRT18 
                 2.3E−05 
                 −16.8 
                 1.6E−05 
               
               
                 209278_s_at 
                 L27624 
                 tissue factor 
                 TFPI2 
                 3.0E−04 
                 −16.1 
                 7.4E−05 
               
               
                   
                   
                 pathway 
                   
                   
                   
                   
               
               
                   
                   
                 inhibitor 2 
                   
                   
                   
                   
               
               
                 203108_at 
                 NM_003979 
                 G protein- 
                 GPRC5A 
                 5.0E−05 
                 −15.9 
                 1.2E−04 
               
               
                   
                   
                 coupled 
                   
                   
                   
                   
               
               
                   
                   
                 receptor, family 
                   
                   
                   
                   
               
               
                   
                   
                 C, group 5, 
                   
                   
                   
                   
               
               
                   
                   
                 member A 
                   
                   
                   
                   
               
               
                 211864_s_at 
                 AF207990 
                 fer-1-like 3, 
                 FER1L3 
                 1.3E−05 
                 −15.7 
                 3.8E−06 
               
               
                   
                   
                 myoferlin ( C. elegans ) 
                   
                   
                   
                   
               
               
                 204470_at 
                 NM_001511 
                 chemokine 
                 CXCL1 
                 9.1E−04 
                 −15.4 
                 2.5E−04 
               
               
                   
                   
                 (C—X—C motif) 
                   
                   
                   
                   
               
               
                   
                   
                 ligand 1 
                   
                   
                   
                   
               
               
                   
                   
                 (melanoma 
                   
                   
                   
                   
               
               
                   
                   
                 growth 
                   
                   
                   
                   
               
               
                   
                   
                 stimulating 
                   
                   
                   
                   
               
               
                   
                   
                 activity, alpha) 
                   
                   
                   
                   
               
               
                 204279_at 
                 NM_002800 
                 proteasome 
                 PSMB9 
                 2.4E−07 
                 −15.0 
                 9.1E−07 
               
               
                   
                   
                 (prosome, 
                   
                   
                   
                   
               
               
                   
                   
                 macropain) 
                   
                   
                   
                   
               
               
                   
                   
                 subunit, beta 
                   
                   
                   
                   
               
               
                   
                   
                 type, 9 (large 
                   
                   
                   
                   
               
               
                   
                   
                 multifunctional 
                   
                   
                   
                   
               
               
                   
                   
                 peptidase 2) 
                   
                   
                   
                   
               
               
                 205627_at 
                 NM_001785 
                 cytidine 
                 CDA 
                 7.0E−04 
                 −14.9 
                 4.8E−04 
               
               
                   
                   
                 deaminase 
                   
                   
                   
                   
               
               
                 212444_at 
                 AA156240 
                 CDNA clone 
                 — 
                 7.8E−05 
                 −14.8 
                 3.2E−04 
               
               
                   
                   
                 IMAGE: 6025865 
                   
                   
                   
                   
               
               
                 201842_s_at 
                 AI826799 
                 EGF-containing 
                 EFEMP1 
                 4.2E−04 
                 −14.3 
                 5.7E−04 
               
               
                   
                   
                 fibulin-like 
                   
                   
                   
                   
               
               
                   
                   
                 extracellular 
                   
                   
                   
                   
               
               
                   
                   
                 matrix protein 1 
                   
                   
                   
                   
               
               
                 208747_s_at 
                 M18767 
                 complement 
                 C1S 
                 4.6E−04 
                 −14.1 
                 6.9E−04 
               
               
                   
                   
                 component 1, s 
                   
                   
                   
                   
               
               
                   
                   
                 subcomponent 
                   
                   
                   
                   
               
               
                 204602_at 
                 NM_012242 
                 dickkopf 
                 DKK1 
                 2.0E−04 
                 −13.9 
                 6.6E−04 
               
               
                   
                   
                 homolog 1 
                   
                   
                   
                   
               
               
                   
                   
                 ( Xenopus   
                   
                   
                   
                   
               
               
                   
                   
                   laevis ) 
                   
                   
                   
                   
               
               
                 201468_s_at 
                 NM_000903 
                 NAD(P)H 
                 NQO1 
                 5.6E−06 
                 −13.7 
                 5.1E−05 
               
               
                   
                   
                 dehydrogenase, 
                   
                   
                   
                   
               
               
                   
                   
                 quinone 1 
                   
                   
                   
                   
               
               
                 201631_s_at 
                 NM_003897 
                 immediate early 
                 IER3 
                 1.1E−06 
                 −13.7 
                 5.8E−05 
               
               
                   
                   
                 response 3 
                   
                   
                   
                   
               
               
                 204222_s_at 
                 NM_006851 
                 GLI 
                 GLIPR1 
                 7.3E−05 
                 −13.0 
                 4.2E−04 
               
               
                   
                   
                 pathogenesis- 
                   
                   
                   
                   
               
               
                   
                   
                 related 1 
                   
                   
                   
                   
               
               
                   
                   
                 (glioma) 
                   
                   
                   
                   
               
               
                 210592_s_at 
                 M55580 
                 spermidine/spermine 
                 SAT1 
                 5.6E−07 
                 −12.6 
                 3.7E−06 
               
               
                   
                   
                 N1- 
                   
                   
                   
                   
               
               
                   
                   
                 acetyltransferase 1 
                   
                   
                   
                   
               
               
                 208949_s_at 
                 BC001120 
                 lectin, 
                 LGALS3 
                 8.9E−04 
                 −11.3 
                 2.3E−04 
               
               
                   
                   
                 galactoside- 
                   
                   
                   
                   
               
               
                   
                   
                 binding, soluble, 
                   
                   
                   
                   
               
               
                   
                   
                 3 (galectin 3) 
                   
                   
                   
                   
               
               
                 206513_at 
                 NM_004833 
                 absent in 
                 AIM2 
                 8.3E−04 
                 −11.0 
                 7.4E−04 
               
               
                   
                   
                 melanoma 2 
                   
                   
                   
                   
               
               
                 203851_at 
                 NM_002178 
                 insulin-like 
                 IGFBP6 
                 1.7E−04 
                 −11.0 
                 1.7E−04 
               
               
                   
                   
                 growth factor 
                   
                   
                   
                   
               
               
                   
                   
                 binding protein 6 
                   
                   
                   
                   
               
               
                 202627_s_at 
                 AL574210 
                 serpin peptidase 
                 SERPINE1 
                 7.1E−04 
                 −10.9 
                 6.4E−04 
               
               
                   
                   
                 inhibitor, clade 
                   
                   
                   
                   
               
               
                   
                   
                 E (nexin, 
                   
                   
                   
                   
               
               
                   
                   
                 plasminogen 
                   
                   
                   
                   
               
               
                   
                   
                 activator 
                   
                   
                   
                   
               
               
                   
                   
                 inhibitor type 1), 
                   
                   
                   
                   
               
               
                   
                   
                 member 1 
                   
                   
                   
                   
               
               
                 210042_s_at 
                 AF073890 
                 cathepsin Z 
                 CTSZ 
                 4.4E−05 
                 −10.8 
                 3.2E−05 
               
               
                 202858_at 
                 NM_006758 
                 U2 small 
                 U2AF1 
                 9.2E−04 
                 −10.7 
                 2.2E−04 
               
               
                   
                   
                 nuclear RNA 
                   
                   
                   
                   
               
               
                   
                   
                 auxiliary factor 1 
                   
                   
                   
                   
               
               
                 208510_s_at 
                 NM_015869 
                 peroxisome 
                 PPARG 
                 8.7E−05 
                 −10.2 
                 1.6E−04 
               
               
                   
                   
                 proliferator- 
                   
                   
                   
                   
               
               
                   
                   
                 activated 
                   
                   
                   
                   
               
               
                   
                   
                 receptor gamma 
                   
                   
                   
                   
               
               
                 202202_s_at 
                 NM_002290 
                 laminin, alpha 4 
                 LAMA4 
                 4.8E−04 
                 −10.2 
                 2.6E−04 
               
               
                 219759_at 
                 NM_022350 
                 leukocyte- 
                 LRAP 
                 6.1E−05 
                 −9.8 
                 6.4E−05 
               
               
                   
                   
                 derived arginine 
                   
                   
                   
                   
               
               
                   
                   
                 aminopeptidase 
                   
                   
                   
                   
               
               
                 205798_at 
                 NM_002185 
                 interleukin 7 
                 IL7R 
                 1.5E−05 
                 −9.8 
                 2.6E−04 
               
               
                   
                   
                 receptor /// 
                   
                   
                   
                   
               
               
                   
                   
                 interleukin 7 
                   
                   
                   
                   
               
               
                   
                   
                 receptor 
                   
                   
                   
                   
               
               
                 202862_at 
                 NM_000137 
                 fumarylacetoacetate 
                 FAH 
                 1.3E−06 
                 −9.8 
                 9.7E−06 
               
               
                   
                   
                 hydrolase 
                   
                   
                   
                   
               
               
                   
                   
                 (fumarylacetoacetase) 
                   
                   
                   
                   
               
               
                 201474_s_at 
                 NM_002204 
                 integrin, alpha 3 
                 ITGA3 
                 3.9E−06 
                 −9.7 
                 6.8E−07 
               
               
                   
                   
                 (antigen 
                   
                   
                   
                   
               
               
                   
                   
                 CD49C, alpha 3 
                   
                   
                   
                   
               
               
                   
                   
                 subunit of VLA- 
                   
                   
                   
                   
               
               
                   
                   
                 3 receptor) 
                   
                   
                   
                   
               
               
                 221059_s_at 
                 NM_021615 
                 coactosin-like 1 
                 COTL1 
                 5.7E−06 
                 −9.6 
                 8.2E−06 
               
               
                   
                   
                 ( Dictyostelium ) 
                   
                   
                   
                   
               
               
                 217744_s_at 
                 NM_022121 
                 PERP, TP53 
                 PERP 
                 3.6E−05 
                 −9.3 
                 2.9E−04 
               
               
                   
                   
                 apoptosis 
                   
                   
                   
                   
               
               
                   
                   
                 effector 
                   
                   
                   
                   
               
               
                 211367_s_at 
                 U13699 
                 caspase 1, 
                 CASP1 
                 7.1E−05 
                 −9.1 
                 7.4E−04 
               
               
                   
                   
                 apoptosis- 
                   
                   
                   
                   
               
               
                   
                   
                 related cysteine 
                   
                   
                   
                   
               
               
                   
                   
                 peptidase 
                   
                   
                   
                   
               
               
                   
                   
                 (interleukin 1, 
                   
                   
                   
                   
               
               
                   
                   
                 beta, convertase) 
                   
                   
                   
                   
               
               
                 209040_s_at 
                 U17496 
                 proteasome 
                 PSMB8 
                 5.8E−09 
                 −9.1 
                 1.1E−06 
               
               
                   
                   
                 (prosome, 
                   
                   
                   
                   
               
               
                   
                   
                 macropain) 
                   
                   
                   
                   
               
               
                   
                   
                 subunit, beta 
                   
                   
                   
                   
               
               
                   
                   
                 type, 8 (large 
                   
                   
                   
                   
               
               
                   
                   
                 multifunctional 
                   
                   
                   
                   
               
               
                   
                   
                 peptidase 7) 
                   
                   
                   
                   
               
               
                 201042_at 
                 AL031651 
                 transglutaminase 
                 TGM2 
                 6.7E−04 
                 −9.1 
                 3.7E−04 
               
               
                   
                   
                 2 (C 
                   
                   
                   
                   
               
               
                   
                   
                 polypeptide, 
                   
                   
                   
                   
               
               
                   
                   
                 protein- 
                   
                   
                   
                   
               
               
                   
                   
                 glutamine- 
                   
                   
                   
                   
               
               
                   
                   
                 gamma- 
                   
                   
                   
                   
               
               
                   
                   
                 glutamyltransferase) 
                   
                   
                   
                   
               
               
                 212473_s_at 
                 BE965029 
                 microtubule 
                 MICAL2 
                 2.3E−04 
                 −8.9 
                 8.0E−04 
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 monoxygenase, 
                   
                   
                   
                   
               
               
                   
                   
                 calponin and 
                   
                   
                   
                   
               
               
                   
                   
                 LIM domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 2 
                   
                   
                   
                   
               
               
                 218211_s_at 
                 NM_024101 
                 melanophilin 
                 MLPH 
                 2.1E−04 
                 −8.8 
                 2.5E−05 
               
               
                 210896_s_at 
                 AF306765 
                 aspartate beta- 
                 ASPH 
                 3.2E−06 
                 −8.2 
                 1.5E−04 
               
               
                   
                   
                 hydroxylase 
                   
                   
                   
                   
               
               
                 210951_x_at 
                 AF125393 
                 RAB27A, 
                 RAB27A 
                 6.0E−06 
                 −8.1 
                 1.7E−05 
               
               
                   
                   
                 member RAS 
                   
                   
                   
                   
               
               
                   
                   
                 oncogene family 
                   
                   
                   
                   
               
               
                 203234_at 
                 NM_003364 
                 uridine 
                 UPP1 
                 1.9E−05 
                 −8.0 
                 2.1E−05 
               
               
                   
                   
                 phosphorylase 1 
                   
                   
                   
                   
               
               
                 209310_s_at 
                 U25804 
                 caspase 4, 
                 CASP4 
                 1.2E−07 
                 −7.8 
                 8.3E−05 
               
               
                   
                   
                 apoptosis- 
                   
                   
                   
                   
               
               
                   
                   
                 related cysteine 
                   
                   
                   
                   
               
               
                   
                   
                 peptidase 
                   
                   
                   
                   
               
               
                 212268_at 
                 NM_030666 
                 serpin peptidase 
                 SERPINB1 
                 5.6E−06 
                 −7.6 
                 1.2E−07 
               
               
                   
                   
                 inhibitor, clade 
                   
                   
                   
                   
               
               
                   
                   
                 B (ovalbumin), 
                   
                   
                   
                   
               
               
                   
                   
                 member 1 
                   
                   
                   
                   
               
               
                 201324_at 
                 NM_001423 
                 epithelial 
                 EMP1 
                 4.0E−05 
                 −7.4 
                 4.2E−06 
               
               
                   
                   
                 membrane 
                   
                   
                   
                   
               
               
                   
                   
                 protein 1 
                   
                   
                   
                   
               
               
                 218084_x_at 
                 NM_014164 
                 FXYD domain 
                 FXYD5 
                 6.8E−06 
                 −7.3 
                 2.4E−05 
               
               
                   
                   
                 containing ion 
                   
                   
                   
                   
               
               
                   
                   
                 transport 
                   
                   
                   
                   
               
               
                   
                   
                 regulator 5 
                   
                   
                   
                   
               
               
                 201170_s_at 
                 NM_003670 
                 basic helix-loop- 
                 BHLHB2 
                 8.1E−05 
                 −7.3 
                 8.4E−05 
               
               
                   
                   
                 helix domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing, class 
                   
                   
                   
                   
               
               
                   
                   
                 B, 2 
                   
                   
                   
                   
               
               
                 218322_s_at 
                 NM_016234 
                 acyl-CoA 
                 ACSL5 
                 9.0E−04 
                 −7.2 
                 2.3E−04 
               
               
                   
                   
                 synthetase long- 
                   
                   
                   
                   
               
               
                   
                   
                 chain family 
                   
                   
                   
                   
               
               
                   
                   
                 member 5 
                   
                   
                   
                   
               
               
                 202863_at 
                 NM_003113 
                 SP100 nuclear 
                 SP100 
                 3.4E−06 
                 −7.1 
                 2.0E−05 
               
               
                   
                   
                 antigen 
                   
                   
                   
                   
               
               
                 214791_at 
                 AK023116 
                 hypothetical 
                 LOC93349 
                 2.7E−06 
                 −7.1 
                 2.8E−05 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                   
                   
                 BC004921 
                   
                   
                   
                   
               
               
                 206461_x_at 
                 NM_005951 
                 metallothionein 
                 MT1H 
                 6.4E−05 
                 −7.1 
                 6.7E−04 
               
               
                   
                   
                 1H 
                   
                   
                   
                   
               
               
                 209679_s_at 
                 BC003379 
                 small trans- 
                 LOC57228 
                 2.9E−06 
                 −6.9 
                 1.5E−05 
               
               
                   
                   
                 membrane and 
                   
                   
                   
                   
               
               
                   
                   
                 glycosylated 
                   
                   
                   
                   
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                 202510_s_at 
                 NM 006291 
                 tumor necrosis 
                 TNFAIP2 
                 9.7E−04 
                 −6.9 
                 3.8E−04 
               
               
                   
                   
                 factor, alpha- 
                   
                   
                   
                   
               
               
                   
                   
                 induced protein 2 
                   
                   
                   
                   
               
               
                 36711_at 
                 AL021977 
                 v-maf 
                 MAFF 
                 2.0E−07 
                 −6.8 
                 4.6E−08 
               
               
                   
                   
                 musculoaponeurotic 
                   
                   
                   
                   
               
               
                   
                   
                 fibrosarcoma 
                   
                   
                   
                   
               
               
                   
                   
                 oncogene 
                   
                   
                   
                   
               
               
                   
                   
                 homolog F 
                   
                   
                   
                   
               
               
                   
                   
                 (avian) 
                   
                   
                   
                   
               
               
                 206632_s_at 
                 NM_004900 
                 apolipoprotein B 
                 APOBEC3B 
                 1.6E−04 
                 −6.6 
                 5.0E−05 
               
               
                   
                   
                 mRNA editing 
                   
                   
                   
                   
               
               
                   
                   
                 enzyme, 
                   
                   
                   
                   
               
               
                   
                   
                 catalytic 
                   
                   
                   
                   
               
               
                   
                   
                 polypeptide-like 
                   
                   
                   
                   
               
               
                   
                   
                 3B 
                   
                   
                   
                   
               
               
                 211456_x_at 
                 AF333388 
                 metallothionein 
                 LOC645745 
                 7.3E−05 
                 −6.4 
                 8.8E−04 
               
               
                   
                   
                 1H-like protein 
                   
                   
                   
                   
               
               
                 214446_at 
                 NM_012081 
                 elongation 
                 ELL2 
                 1.9E−05 
                 −6.3 
                 2.1E−05 
               
               
                   
                   
                 factor, RNA 
                   
                   
                   
                   
               
               
                   
                   
                 polymerase II, 2 
                   
                   
                   
                   
               
               
                 220016_at 
                 NM_024060 
                 AHNAK 
                 AHNAK 
                 9.7E−04 
                 −6.0 
                 2.9E−04 
               
               
                   
                   
                 nucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                 (desmoyokin) 
                   
                   
                   
                   
               
               
                 205100_at 
                 NM_005110 
                 glutamine- 
                 GFPT2 
                 1.3E−04 
                 −5.9 
                 2.7E−04 
               
               
                   
                   
                 fructose-6- 
                   
                   
                   
                   
               
               
                   
                   
                 phosphate 
                   
                   
                   
                   
               
               
                   
                   
                 transaminase 2 
                   
                   
                   
                   
               
               
                 210538_s_at 
                 U37546 
                 baculoviral IAP 
                 BIRC3 
                 8.8E−04 
                 −5.8 
                 2.3E−04 
               
               
                   
                   
                 repeat- 
                   
                   
                   
                   
               
               
                   
                   
                 containing 3 
                   
                   
                   
                   
               
               
                 216336_x_at 
                 AL031602 
                 metallothionein 
                 MT1M 
                 1.2E−04 
                 −5.8 
                 1.8E−04 
               
               
                   
                   
                 1M 
                   
                   
                   
                   
               
               
                 210117_at 
                 AF311312 
                 sperm 
                 SPAG1 
                 1.2E−04 
                 −5.7 
                 5.8E−04 
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 antigen 1 
                   
                   
                   
                   
               
               
                 216985_s_at 
                 AJ002077 
                 syntaxin 3 
                 STX3 
                 1.4E−06 
                 −5.6 
                 5.3E−06 
               
               
                 217165_x_at 
                 M10943 
                 metallothionein 
                 MT1F 
                 2.8E−04 
                 −5.6 
                 9.8E−04 
               
               
                   
                   
                 1F (functional) 
                   
                   
                   
                   
               
               
                 204017_at 
                 NM_006855 
                 KDEL (Lys- 
                 KDELR3 
                 1.2E−05 
                 −5.5 
                 3.9E−04 
               
               
                   
                   
                 Asp-Glu-Leu) 
                   
                   
                   
                   
               
               
                   
                   
                 endoplasmic 
                   
                   
                   
                   
               
               
                   
                   
                 reticulum 
                   
                   
                   
                   
               
               
                   
                   
                 protein retention 
                   
                   
                   
                   
               
               
                   
                   
                 receptor 3 
                   
                   
                   
                   
               
               
                 217996_at 
                 AA576961 
                 pleckstrin 
                 PHLDA1 
                 2.2E−04 
                 −5.3 
                 3.8E−04 
               
               
                   
                   
                 homology-like 
                   
                   
                   
                   
               
               
                   
                   
                 domain, family 
                   
                   
                   
                   
               
               
                   
                   
                 A, member 1 
                   
                   
                   
                   
               
               
                 202733_at 
                 NM_004199 
                 procollagen- 
                 P4HA2 
                 3.7E−05 
                 −5.3 
                 6.9E−05 
               
               
                   
                   
                 proline, 2- 
                   
                   
                   
                   
               
               
                   
                   
                 oxoglutarate 4- 
                   
                   
                   
                   
               
               
                   
                   
                 dioxygenase 
                   
                   
                   
                   
               
               
                   
                   
                 (proline 4- 
                   
                   
                   
                   
               
               
                   
                   
                 hydroxylase), 
                   
                   
                   
                   
               
               
                   
                   
                 alpha 
                   
                   
                   
                   
               
               
                   
                   
                 polypeptide II 
                   
                   
                   
                   
               
               
                 209457_at 
                 U16996 
                 dual specificity 
                 DUSP5 
                 1.3E−04 
                 −5.0 
                 9.8E−04 
               
               
                   
                   
                 phosphatase 5 
                   
                   
                   
                   
               
               
                 214866_at 
                 X74039 
                 plasminogen 
                 PLAUR 
                 4.5E−05 
                 −5.0 
                 1.2E−04 
               
               
                   
                   
                 activator, 
                   
                   
                   
                   
               
               
                   
                   
                 urokinase 
                   
                   
                   
                   
               
               
                   
                   
                 receptor 
                   
                   
                   
                   
               
               
                 211612_s_at 
                 U62858 
                 interleukin 13 
                 IL13RA1 
                 1.5E−04 
                 −5.0 
                 4.3E−04 
               
               
                   
                   
                 receptor, alpha 1 
                   
                   
                   
                   
               
               
                   
                   
                 /// interleukin 13 
                   
                   
                   
                   
               
               
                   
                   
                 receptor, alpha 1 
                   
                   
                   
                   
               
               
                 210987_x_at 
                 M19267 
                 tropomyosin 1 
                 TPM1 
                 7.4E−04 
                 −5.0 
                 2.3E−05 
               
               
                   
                   
                 (alpha) 
                   
                   
                   
                   
               
               
                 213274_s_at 
                 AA020826 
                 cathepsin B 
                 CTSB 
                 7.9E−04 
                 −5.0 
                 1.6E−04 
               
               
                 202949_s_at 
                 NM_001450 
                 four and a half 
                 FHL2 
                 5.6E−05 
                 −4.9 
                 5.2E−04 
               
               
                   
                   
                 LIM domains 2 
                   
                   
                   
                   
               
               
                 203939_at 
                 NM_002526 
                 5′-nucleotidase, 
                 NT5E 
                 9.5E−04 
                 −4.9 
                 6.1E−05 
               
               
                   
                   
                 ecto (CD73) 
                   
                   
                   
                   
               
               
                 222294_s_at 
                 AW971415 
                 CDNA clone 
                 — 
                 8.3E−06 
                 −4.9 
                 1.2E−05 
               
               
                   
                   
                 IMAGE: 5745639 
                   
                   
                   
                   
               
               
                 202085_at 
                 NM_004817 
                 tight junction 
                 TJP2 
                 1.4E−04 
                 −4.9 
                 2.8E−04 
               
               
                   
                   
                 protein 2 (zona 
                   
                   
                   
                   
               
               
                   
                   
                 occludens 2) 
                   
                   
                   
                   
               
               
                 209706_at 
                 AF247704 
                 NK3 
                 NKX3-1 
                 6.0E−05 
                 −4.9 
                 1.8E−04 
               
               
                   
                   
                 transcription 
                   
                   
                   
                   
               
               
                   
                   
                 factor related, 
                   
                   
                   
                   
               
               
                   
                   
                 locus 1 
                   
                   
                   
                   
               
               
                   
                   
                 ( Drosophila ) 
                   
                   
                   
                   
               
               
                 222150_s_at 
                 AK026747 
                 hypothetical 
                 LOC54103 
                 1.8E−05 
                 −4.8 
                 2.6E−06 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                   
                   
                 LOC54103 
                   
                   
                   
                   
               
               
                 200632_s_at 
                 NM_006096 
                 N-myc 
                 NDRG1 
                 6.2E−04 
                 −4.8 
                 4.1E−04 
               
               
                   
                   
                 downstream 
                   
                   
                   
                   
               
               
                   
                   
                 regulated gene 1 
                   
                   
                   
                   
               
               
                 210136_at 
                 AW070431 
                 myelin basic 
                 MBP 
                 1.6E−05 
                 −4.6 
                 1.0E−04 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                 205579_at 
                 NM_000861 
                 histamine 
                 HRH1 
                 6.3E−05 
                 −4.6 
                 1.5E−04 
               
               
                   
                   
                 receptor H1 
                   
                   
                   
                   
               
               
                 201412_at 
                 NM_014045 
                 low density 
                 LRP10 
                 8.4E−05 
                 −4.6 
                 2.8E−04 
               
               
                   
                   
                 lipoprotein 
                   
                   
                   
                   
               
               
                   
                   
                 receptor-related 
                   
                   
                   
                   
               
               
                   
                   
                 protein 10 
                   
                   
                   
                   
               
               
                 211799_x_at 
                 U62824 
                 major 
                 HLA-C 
                 5.4E−04 
                 −4.6 
                 8.6E−04 
               
               
                   
                   
                 histocompatibility 
                   
                   
                   
                   
               
               
                   
                   
                 complex, 
                   
                   
                   
                   
               
               
                   
                   
                 class I, C 
                   
                   
                   
                   
               
               
                 203005_at 
                 NM_002342 
                 lymphotoxin 
                 LTBR 
                 1.1E−06 
                 −4.5 
                 4.4E−06 
               
               
                   
                   
                 beta receptor 
                   
                   
                   
                   
               
               
                   
                   
                 (TNFR 
                   
                   
                   
                   
               
               
                   
                   
                 superfamily, 
                   
                   
                   
                   
               
               
                   
                   
                 member 3) 
                   
                   
                   
                   
               
               
                 209417_s_at 
                 BC001356 
                 interferon- 
                 IFI35 
                 1.7E−05 
                 −4.3 
                 7.7E−05 
               
               
                   
                   
                 induced protein 
                   
                   
                   
                   
               
               
                   
                   
                 35 
                   
                   
                   
                   
               
               
                 203041_s_at 
                 J04183 
                 lysosomal- 
                 LAMP2 
                 8.4E−04 
                 −4.3 
                 9.0E−04 
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 membrane 
                   
                   
                   
                   
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                 213865_at 
                 AI378788 
                 discoidin, CUB 
                 DCBLD2 
                 8.1E−04 
                 −4.2 
                 3.6E−04 
               
               
                   
                   
                 and LCCL 
                   
                   
                   
                   
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 2 
                   
                   
                   
                   
               
               
                 201649_at 
                 NM_004223 
                 ubiquitin- 
                 UBE2L6 
                 2.6E−04 
                 −4.2 
                 6.4E−05 
               
               
                   
                   
                 conjugating 
                   
                   
                   
                   
               
               
                   
                   
                 enzyme E2L 6 
                   
                   
                   
                   
               
               
                 202180_s_at 
                 NM_017458 
                 major vault 
                 MVP 
                 3.1E−04 
                 −4.1 
                 2.7E−04 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                 211000_s_at 
                 AB015706 
                 interleukin 6 
                 IL6ST 
                 1.8E−04 
                 −4.1 
                 8.0E−04 
               
               
                   
                   
                 signal 
                   
                   
                   
                   
               
               
                   
                   
                 transducer 
                   
                   
                   
                   
               
               
                   
                   
                 (gp 130, 
                   
                   
                   
                   
               
               
                   
                   
                 oncostatin M 
                   
                   
                   
                   
               
               
                   
                   
                 receptor) 
                   
                   
                   
                   
               
               
                 203518_at 
                 NM_000081 
                 lysosomal 
                 LYST 
                 4.9E−05 
                 −4.0 
                 4.4E−05 
               
               
                   
                   
                 trafficking 
                   
                   
                   
                   
               
               
                   
                   
                 regulator 
                   
                   
                   
                   
               
               
                 205896_at 
                 NM_003059 
                 solute carrier 
                 SLC22A4 
                 3.2E−04 
                 −4.0 
                 6.6E−04 
               
               
                   
                   
                 family 22 
                   
                   
                   
                   
               
               
                   
                   
                 (organic cation 
                   
                   
                   
                   
               
               
                   
                   
                 transporter), 
                   
                   
                   
                   
               
               
                   
                   
                 member 4 
                   
                   
                   
                   
               
               
                 201482_at 
                 NM_002826 
                 quiescin Q6 
                 QSCN6 
                 2.1E−05 
                 −4.0 
                 6.0E−05 
               
               
                 218631_at 
                 NM_021732 
                 arginine 
                 AVPI1 
                 8.6E−04 
                 −3.9 
                 2.6E−04 
               
               
                   
                   
                 vasopressin- 
                   
                   
                   
                   
               
               
                   
                   
                 induced 1 
                   
                   
                   
                   
               
               
                 201471_s_at 
                 NM_003900 
                 sequestosome 1 
                 SQSTM1 
                 1.4E−04 
                 −3.9 
                 4.8E−04 
               
               
                 212463_at 
                 BE379006 
                 CD59 molecule, 
                 CD59 
                 2.6E−04 
                 −3.8 
                 3.5E−04 
               
               
                   
                   
                 complement 
                   
                   
                   
                   
               
               
                   
                   
                 regulatory 
                   
                   
                   
                   
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                 205266_at 
                 NM_002309 
                 leukemia 
                 LIF 
                 8.2E−05 
                 −3.8 
                 5.1E−05 
               
               
                   
                   
                 inhibitory factor 
                   
                   
                   
                   
               
               
                   
                   
                 (cholinergic 
                   
                   
                   
                   
               
               
                   
                   
                 differentiation 
                   
                   
                   
                   
               
               
                   
                   
                 factor) 
                   
                   
                   
                   
               
               
                 204745_x_at 
                 NM_005950 
                 metallothionein 
                 MT1G 
                 1.6E−04 
                 −3.7 
                 4.4E−04 
               
               
                   
                   
                 1G 
                   
                   
                   
                   
               
               
                 202087_s_at 
                 NM_001912 
                 cathepsin L 
                 CTSL 
                 2.7E−04 
                 −3.7 
                 6.1E−04 
               
               
                 202531_at 
                 NM_002198 
                 interferon 
                 IRF1 
                 2.3E−04 
                 −3.7 
                 3.1E−04 
               
               
                   
                   
                 regulatory factor 1 
                   
                   
                   
                   
               
               
                 205398_s_at 
                 NM_005902 
                 SMAD family 
                 SMAD3 
                 1.9E−05 
                 −3.7 
                 6.4E−04 
               
               
                   
                   
                 member 3 
                   
                   
                   
                   
               
               
                 202201_at 
                 NM_000713 
                 biliverdin 
                 BLVRB 
                 2.5E−05 
                 −3.6 
                 3.6E−05 
               
               
                   
                   
                 reductase B 
                   
                   
                   
                   
               
               
                   
                   
                 (flavin reductase 
                   
                   
                   
                   
               
               
                   
                   
                 (NADPH)) 
                   
                   
                   
                   
               
               
                 202499_s_at 
                 NM_006931 
                 solute carrier 
                 SLC2A3 
                 4.8E−04 
                 −3.6 
                 5.9E−05 
               
               
                   
                   
                 family 2 
                   
                   
                   
                   
               
               
                   
                   
                 (facilitated 
                   
                   
                   
                   
               
               
                   
                   
                 glucose 
                   
                   
                   
                   
               
               
                   
                   
                 transporter), 
                   
                   
                   
                   
               
               
                   
                   
                 member 3 
                   
                   
                   
                   
               
               
                 203329_at 
                 NM_002845 
                 protein tyrosine 
                 PTPRM 
                 2.2E−05 
                 −3.6 
                 8.0E−05 
               
               
                   
                   
                 phosphatase, 
                   
                   
                   
                   
               
               
                   
                   
                 receptor type, M 
                   
                   
                   
                   
               
               
                 218273_s_at 
                 NM_018444 
                 protein 
                 PPM2C 
                 1.8E−05 
                 −3.6 
                 2.0E−05 
               
               
                   
                   
                 phosphatase 2C, 
                   
                   
                   
                   
               
               
                   
                   
                 magnesium- 
                   
                   
                   
                   
               
               
                   
                   
                 dependent, 
                   
                   
                   
                   
               
               
                   
                   
                 catalytic subunit 
                   
                   
                   
                   
               
               
                 202948_at 
                 NM_000877 
                 interleukin 1 
                 IL1R1 
                 4.3E−04 
                 −3.5 
                 6.5E−04 
               
               
                   
                   
                 receptor, type I 
                   
                   
                   
                   
               
               
                 204158_s_at 
                 NM_006019 
                 T-cell, immune 
                 TCIRG1 
                 3.1E−06 
                 −3.4 
                 1.8E−04 
               
               
                   
                   
                 regulator 1, 
                   
                   
                   
                   
               
               
                   
                   
                 ATPase, H+ 
                   
                   
                   
                   
               
               
                   
                   
                 transporting, 
                   
                   
                   
                   
               
               
                   
                   
                 lysosomal V0 
                   
                   
                   
                   
               
               
                   
                   
                 subunit A3 
                   
                   
                   
                   
               
               
                 202861_at 
                 NM_002616 
                 period homolog 
                 PER1 
                 5.6E−05 
                 −3.4 
                 3.8E−05 
               
               
                   
                   
                 1 ( Drosophila ) 
                   
                   
                   
                   
               
               
                 219691_at 
                 NM_017654 
                 sterile alpha 
                 SAMD9 
                 1.1E−05 
                 −3.4 
                 8.9E−05 
               
               
                   
                   
                 motif domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 9 
                   
                   
                   
                   
               
               
                 202074_s_at 
                 NM_021980 
                 optineurin 
                 OPTN 
                 9.9E−04 
                 −3.3 
                 6.4E−04 
               
               
                 204981_at 
                 NM_002555 
                 solute carrier 
                 SLC22A18 
                 7.4E−04 
                 −3.3 
                 7.4E−06 
               
               
                   
                   
                 family 22 
                   
                   
                   
                   
               
               
                   
                   
                 (organic cation 
                   
                   
                   
                   
               
               
                   
                   
                 transporter), 
                   
                   
                   
                   
               
               
                   
                   
                 member 18 
                   
                   
                   
                   
               
               
                 202693_s_at 
                 AW194730 
                 serine/threonine 
                 STK17A 
                 1.6E−04 
                 −3.3 
                 1.0E−04 
               
               
                   
                   
                 kinase 17a 
                   
                   
                   
                   
               
               
                   
                   
                 (apoptosis- 
                   
                   
                   
                   
               
               
                   
                   
                 inducing) 
                   
                   
                   
                   
               
               
                 207467_x_at 
                 NM_001750 
                 calpastatin 
                 CAST 
                 3.4E−05 
                 −3.2 
                 1.6E−04 
               
               
                 218552_at 
                 NM_018281 
                 enoyl Coenzyme 
                 ECHDC2 
                 1.0E−04 
                 −3.2 
                 3.0E−04 
               
               
                   
                   
                 A hydratase 
                   
                   
                   
                   
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 2 
                   
                   
                   
                   
               
               
                 204863_s_at 
                 BE856546 
                 interleukin 6 
                 IL6ST 
                 4.3E−04 
                 −3.2 
                 9.8E−04 
               
               
                   
                   
                 signal 
                 /// 
                   
                   
                   
               
               
                   
                   
                 transducer 
                 MAGEA4 
                   
                   
                   
               
               
                   
                   
                 (gp130, 
                   
                   
                   
                   
               
               
                   
                   
                 oncostatin M 
                   
                   
                   
                   
               
               
                   
                   
                 receptor) /// 
                   
                   
                   
                   
               
               
                   
                   
                 melanoma 
                   
                   
                   
                   
               
               
                   
                   
                 antigen family 
                   
                   
                   
                   
               
               
                   
                   
                 A, 4 
                   
                   
                   
                   
               
               
                 218983_at 
                 NM_016546 
                 complement 
                 C1RL 
                 5.1E−05 
                 −3.2 
                 6.4E−05 
               
               
                   
                   
                 component 1, r 
                   
                   
                   
                   
               
               
                   
                   
                 subcomponent- 
                   
                   
                   
                   
               
               
                   
                   
                 like 
                   
                   
                   
                   
               
               
                 205640_at 
                 NM_000694 
                 aldehyde 
                 ALDH3B1 
                 6.0E−05 
                 −3.1 
                 2.3E−05 
               
               
                   
                   
                 dehydrogenase 3 
                   
                   
                   
                   
               
               
                   
                   
                 family, member 
                   
                   
                   
                   
               
               
                   
                   
                 B1 
                   
                   
                   
                   
               
               
                 212737_at 
                 AL513583 
                 GM2 
                 GM2A 
                 3.9E−04 
                 −3.1 
                 3.2E−05 
               
               
                   
                   
                 ganglioside 
                   
                   
                   
                   
               
               
                   
                   
                 activator 
                   
                   
                   
                   
               
               
                 203430_at 
                 NM_014320 
                 heme binding 
                 HEBP2 
                 3.5E−04 
                 −3.1 
                 1.9E−05 
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                 210978_s_at 
                 BC002616 
                 transgelin 2 
                 TAGLN2 
                 3.3E−04 
                 −3.1 
                 3.1E−05 
               
               
                 209304_x_at 
                 AF087853 
                 growth arrest 
                 GADD45B 
                 5.5E−04 
                 −3.0 
                 9.4E−04 
               
               
                   
                   
                 and DNA- 
                   
                   
                   
                   
               
               
                   
                   
                 damage- 
                   
                   
                   
                   
               
               
                   
                   
                 inducible, beta 
                   
                   
                   
                   
               
               
                 211528_x_at 
                 M90685 
                 HLA-G 
                 HLA-G 
                 3.1E−04 
                 −3.0 
                 9.7E−04 
               
               
                   
                   
                 histocompatibility 
                   
                   
                   
                   
               
               
                   
                   
                 antigen, class 
                   
                   
                   
                   
               
               
                   
                   
                 I, G 
                   
                   
                   
                   
               
               
                 204747_at 
                 NM_001549 
                 interferon- 
                 IFIT3 
                 3.5E−05 
                 −3.0 
                 4.0E−04 
               
               
                   
                   
                 induced protein 
                   
                   
                   
                   
               
               
                   
                   
                 with 
                   
                   
                   
                   
               
               
                   
                   
                 tetratricopeptide 
                   
                   
                   
                   
               
               
                   
                   
                 repeats 3 
                   
                   
                   
                   
               
               
                 217739_s_at 
                 NM_005746 
                 pre-B-cell 
                 PBEF1 
                 3.6E−05 
                 −3.0 
                 1.2E−04 
               
               
                   
                   
                 colony 
                   
                   
                   
                   
               
               
                   
                   
                 enhancing factor 1 
                   
                   
                   
                   
               
               
                 202307_s_at 
                 NM_000593 
                 transporter 1, 
                 TAP1 
                 1.2E−05 
                 −3.0 
                 6.1E−04 
               
               
                   
                   
                 ATP-binding 
                   
                   
                   
                   
               
               
                   
                   
                 cassette, sub- 
                   
                   
                   
                   
               
               
                   
                   
                 family B 
                   
                   
                   
                   
               
               
                   
                   
                 (MDR/TAP) 
                   
                   
                   
                   
               
               
                 207375_s_at 
                 NM_002189 
                 interleukin 15 
                 IL15RA 
                 1.6E−04 
                 −3.0 
                 8.1E−04 
               
               
                   
                   
                 receptor, alpha 
                   
                   
                   
                   
               
               
                 219716_at 
                 NM_030641 
                 apolipoprotein 
                 APOL6 
                 4.1E−04 
                 −2.9 
                 4.2E−05 
               
               
                   
                   
                 L, 6 
                   
                   
                   
                   
               
               
                 212552_at 
                 BE617588 
                 hippocalcin-like 1 
                 HPCAL1 
                 2.2E−04 
                 −2.9 
                 1.0E−04 
               
               
                 217998_at 
                 NM_007350 
                 pleckstrin 
                 PHLDA1 
                 9.7E−05 
                 −2.9 
                 3.6E−04 
               
               
                   
                   
                 homology-like 
                 /// 
                   
                   
                   
               
               
                   
                   
                 domain, family 
                 LOC652993 
                   
                   
                   
               
               
                   
                   
                 A, member 1 /// 
                   
                   
                   
                   
               
               
                   
                   
                 hypothetical 
                   
                   
                   
                   
               
               
                   
                   
                 LOC652993 
                   
                   
                   
                   
               
               
                 202275_at 
                 NM_000402 
                 glucose-6- 
                 G6PD 
                 6.9E−05 
                 −2.9 
                 1.2E−04 
               
               
                   
                   
                 phosphate 
                   
                   
                   
                   
               
               
                   
                   
                 dehydrogenase 
                   
                   
                   
                   
               
               
                 201954_at 
                 NM_005720 
                 actin related 
                 ARPC1B 
                 7.2E−04 
                 −2.9 
                 5.3E−04 
               
               
                   
                   
                 protein 2/3 
                 /// 
                   
                   
                   
               
               
                   
                   
                 complex, 
                 LOC653888 
                   
                   
                   
               
               
                   
                   
                 subunit 1B, 
                   
                   
                   
                   
               
               
                   
                   
                 41 kDa /// 
                   
                   
                   
                   
               
               
                   
                   
                 similar to Actin- 
                   
                   
                   
                   
               
               
                   
                   
                 related protein 
                   
                   
                   
                   
               
               
                   
                   
                 2/3 complex 
                   
                   
                   
                   
               
               
                   
                   
                 subunit 1B 
                   
                   
                   
                   
               
               
                   
                   
                 (ARP2/3 
                   
                   
                   
                   
               
               
                   
                   
                 complex 41 kDa 
                   
                   
                   
                   
               
               
                   
                   
                 subunit) (p41- 
                   
                   
                   
                   
               
               
                   
                   
                 ARC) 
                   
                   
                   
                   
               
               
                 214447_at 
                 NM_005238 
                 v-ets 
                 ETS1 
                 2.5E−04 
                 −2.8 
                 8.3E−04 
               
               
                   
                   
                 erythroblastosis 
                   
                   
                   
                   
               
               
                   
                   
                 virus E26 
                   
                   
                   
                   
               
               
                   
                   
                 oncogene 
                   
                   
                   
                   
               
               
                   
                   
                 homolog 1 
                   
                   
                   
                   
               
               
                   
                   
                 (avian) 
                   
                   
                   
                   
               
               
                 221044_s_at 
                 NM_021616 
                 tripartite motif- 
                 TRIM34 
                 2.7E−04 
                 −2.8 
                 8.1E−04 
               
               
                   
                   
                 containing 34 /// 
                 /// 
                   
                   
                   
               
               
                   
                   
                 tripartite motif- 
                 TRIM6- 
                   
                   
                   
               
               
                   
                   
                 containing 6 and 
                 TRIM34 
                   
                   
                   
               
               
                   
                   
                 tripartite motif- 
                   
                   
                   
                   
               
               
                   
                   
                 containing 34 
                   
                   
                   
                   
               
               
                 221843_s_at 
                 AA195017 
                 KIAA1609 
                 KIAA1609 
                 6.9E−04 
                 −2.8 
                 7.7E−05 
               
               
                 213083_at 
                 AJ005866 
                 solute carrier 
                 SLC35D2 
                 2.0E−04 
                 −2.7 
                 2.2E−05 
               
               
                   
                   
                 family 35, 
                   
                   
                   
                   
               
               
                   
                   
                 member D2 
                   
                   
                   
                   
               
               
                 208637_x_at 
                 BC003576 
                 actinin, alpha 1 
                 ACTN1 
                 2.9E−04 
                 −2.7 
                 1.7E−04 
               
               
                 53720_at 
                 AI862559 
                 hypothetical 
                 FLJ11286 
                 2.4E−05 
                 −2.7 
                 6.6E−06 
               
               
                   
                   
                 protein 
                   
                   
                   
                   
               
               
                   
                   
                 FLJ11286 
                   
                   
                   
                   
               
               
                 208829_at 
                 AF029750 
                 TAP binding 
                 TAPBP 
                 6.8E−04 
                 −2.6 
                 8.3E−04 
               
               
                   
                   
                 protein (tapasin) 
                   
                   
                   
                   
               
               
                 204682_at 
                 NM_000428 
                 latent 
                 LTBP2 
                 5.9E−04 
                 −2.6 
                 2.4E−04 
               
               
                   
                   
                 transforming 
                   
                   
                   
                   
               
               
                   
                   
                 growth factor 
                   
                   
                   
                   
               
               
                   
                   
                 beta binding 
                   
                   
                   
                   
               
               
                   
                   
                 protein 2 
                   
                   
                   
                   
               
               
                 208613_s_at 
                 AV712733 
                 filamin B, beta 
                 FLNB 
                 2.1E−04 
                 −2.6 
                 2.4E−04 
               
               
                   
                   
                 (actin binding 
                   
                   
                   
                   
               
               
                   
                   
                 protein 278) 
                   
                   
                   
                   
               
               
                 201944_at 
                 NM_000521 
                 hexosaminidase 
                 HEXB 
                 3.2E−05 
                 −2.6 
                 4.4E−04 
               
               
                   
                   
                 B (beta 
                   
                   
                   
                   
               
               
                   
                   
                 polypeptide) 
                   
                   
                   
                   
               
               
                 208872_s_at 
                 AA814140 
                 receptor 
                 REEP5 
                 1.6E−05 
                 −2.6 
                 2.0E−04 
               
               
                   
                   
                 accessory 
                   
                   
                   
                   
               
               
                   
                   
                 protein 5 
                   
                   
                   
                   
               
               
                 218747_s_at 
                 NM_018009 
                 TAP binding 
                 TAPBPL 
                 9.1E−04 
                 −2.6 
                 2.7E−04 
               
               
                   
                   
                 protein-like 
                   
                   
                   
                   
               
               
                 209546_s_at 
                 AF323540 
                 apolipoprotein 
                 APOL1 
                 2.4E−04 
                 −2.6 
                 7.1E−05 
               
               
                   
                   
                 L, 1 
                   
                   
                   
                   
               
               
                 205032_at 
                 NM_002203 
                 integrin, alpha 2 
                 ITGA2 
                 7.2E−05 
                 −2.5 
                 4.9E−04 
               
               
                   
                   
                 (CD49B, alpha 
                   
                   
                   
                   
               
               
                   
                   
                 2 subunit of 
                   
                   
                   
                   
               
               
                   
                   
                 VLA-2 receptor) 
                   
                   
                   
                   
               
               
                 204769_s_at 
                 M74447 
                 transporter 2, 
                 TAP2 
                 1.6E−05 
                 −2.5 
                 1.4E−05 
               
               
                   
                   
                 ATP-binding 
                   
                   
                   
                   
               
               
                   
                   
                 cassette, sub- 
                   
                   
                   
                   
               
               
                   
                   
                 family B 
                   
                   
                   
                   
               
               
                   
                   
                 (MDR/TAP) 
                   
                   
                   
                   
               
               
                 206284_x_at 
                 NM_001834 
                 clathrin, light 
                 CLTB 
                 3.9E−04 
                 −2.4 
                 4.3E−05 
               
               
                   
                   
                 chain (Lcb) 
                   
                   
                   
                   
               
               
                 204034_at 
                 NM_014297 
                 ethylmalonic 
                 ETHE1 
                 5.5E−04 
                 −2.4 
                 2.2E−05 
               
               
                   
                   
                 encephalopathy 1 
                   
                   
                   
                   
               
               
                 219684_at 
                 NM_022147 
                 receptor 
                 RTP4 
                 7.9E−04 
                 −2.4 
                 5.4E−04 
               
               
                   
                   
                 (chemosensory) 
                   
                   
                   
                   
               
               
                   
                   
                 transporter 
                   
                   
                   
                   
               
               
                   
                   
                 protein 4 
                   
                   
                   
                   
               
               
                 211769_x_at 
                 BC006088 
                 serine 
                 SERINC3 
                 1.7E−06 
                 −2.4 
                 1.1E−04 
               
               
                   
                   
                 incorporator 3 
                   
                   
                   
                   
               
               
                   
                   
                 /// serine 
                   
                   
                   
                   
               
               
                   
                   
                 incorporator 3 
                   
                   
                   
                   
               
               
                 213272_s_at 
                 AF070596 
                 transmembrane 
                 TMEM159 
                 5.6E−05 
                 −2.4 
                 7.6E−05 
               
               
                   
                   
                 protein 159 
                   
                   
                   
                   
               
               
                 201587_s_at 
                 NM_001569 
                 interleukin-1 
                 IRAK1 
                 1.3E−04 
                 −2.4 
                 1.4E−04 
               
               
                   
                   
                 receptor- 
                   
                   
                   
                   
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 kinase 1 
                   
                   
                   
                   
               
               
                 203925_at 
                 NM_002061 
                 glutamate- 
                 GCLM 
                 2.3E−04 
                 −2.4 
                 4.2E−04 
               
               
                   
                   
                 cysteine ligase, 
                   
                   
                   
                   
               
               
                   
                   
                 modifier subunit 
                   
                   
                   
                   
               
               
                 220761_s_at 
                 NM_016281 
                 TAO kinase 3 
                 TAOK3 
                 8.4E−05 
                 −2.3 
                 2.0E−07 
               
               
                 214783_s_at 
                 BG177920 
                 annexin A11 
                 ANXA11 
                 2.4E−04 
                 −2.3 
                 8.6E−04 
               
               
                 217751_at 
                 NM_015917 
                 glutathione S- 
                 GSTK1 
                 7.3E−04 
                 −2.3 
                 5.4E−04 
               
               
                   
                   
                 transferase 
                   
                   
                   
                   
               
               
                   
                   
                 kappa 1 
                   
                   
                   
                   
               
               
                 203045_at 
                 NM_004148 
                 ninjurin 1 
                 NINJ1 
                 3.8E−05 
                 −2.3 
                 2.7E−04 
               
               
                 203167_at 
                 NM_003255 
                 TIMP 
                 TIMP2 
                 9.0E−04 
                 −2.3 
                 5.5E−04 
               
               
                   
                   
                 metallopeptidase 
                   
                   
                   
                   
               
               
                   
                   
                 inhibitor 2 
                   
                   
                   
                   
               
               
                 60471_at 
                 AA625133 
                 Ras and Rab 
                 RIN3 
                 5.9E−05 
                 −2.2 
                 2.7E−04 
               
               
                   
                   
                 interactor 3 
                   
                   
                   
                   
               
               
                 209179_s_at 
                 BC003164 
                 leukocyte 
                 LENG4 
                 7.8E−06 
                 −2.2 
                 1.8E−04 
               
               
                   
                   
                 receptor cluster 
                   
                   
                   
                   
               
               
                   
                   
                 (LRC) member 4 
                   
                   
                   
                   
               
               
                 202013_s_at 
                 NM_000401 
                 exostoses 
                 EXT2 
                 4.7E−05 
                 −2.2 
                 4.2E−04 
               
               
                   
                   
                 (multiple) 2 
                   
                   
                   
                   
               
               
                 218739_at 
                 NM_016006 
                 abhydrolase 
                 ABHD5 
                 3.0E−04 
                 −2.2 
                 9.1E−04 
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 5 
                   
                   
                   
                   
               
               
                 219677_at 
                 NM_025106 
                 splA/ryanodine 
                 SPSB1 
                 3.9E−06 
                 −2.2 
                 1.1E−04 
               
               
                   
                   
                 receptor domain 
                   
                   
                   
                   
               
               
                   
                   
                 and SOCS box 
                   
                   
                   
                   
               
               
                   
                   
                 containing 1 
                   
                   
                   
                   
               
               
                 209575_at 
                 BC001903 
                 interleukin 10 
                 IL10RB 
                 2.8E−04 
                 −2.2 
                 2.9E−05 
               
               
                   
                   
                 receptor, beta 
                   
                   
                   
                   
               
               
                 218154_at 
                 NM_024736 
                 gasdermin 
                 GSDMDC1 
                 5.0E−09 
                 −2.2 
                 7.2E−06 
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 1 
                   
                   
                   
                   
               
               
                 201847_at 
                 NM_000235 
                 lipase A, 
                 LIPA 
                 3.3E−04 
                 −2.2 
                 2.2E−05 
               
               
                   
                   
                 lysosomal acid, 
                   
                   
                   
                   
               
               
                   
                   
                 cholesterol 
                   
                   
                   
                   
               
               
                   
                   
                 esterase 
                   
                   
                   
                   
               
               
                   
                   
                 (Wolman 
                   
                   
                   
                   
               
               
                   
                   
                 disease) 
                   
                   
                   
                   
               
               
                 201953_at 
                 NM_006384 
                 calcium and 
                 CIB1 
                 1.2E−04 
                 −2.2 
                 6.5E−04 
               
               
                   
                   
                 integrin binding 
                   
                   
                   
                   
               
               
                   
                   
                 1 (calmyrin) 
                   
                   
                   
                   
               
               
                 200752_s_at 
                 NM_005186 
                 calpain 1, (mu/I) 
                 CAPN1 
                 3.3E−04 
                 −2.2 
                 4.9E−04 
               
               
                   
                   
                 large subunit 
                   
                   
                   
                   
               
               
                 205084_at 
                 NM_018844 
                 B-cell receptor- 
                 BCAP29 
                 8.0E−04 
                 −2.1 
                 6.6E−04 
               
               
                   
                   
                 associated 
                   
                   
                   
                   
               
               
                   
                   
                 protein 29 
                   
                   
                   
                   
               
               
                 221827_at 
                 BE788439 
                 RanBP-type and 
                 RBCK1 
                 2.6E−06 
                 −2.1 
                 1.9E−04 
               
               
                   
                   
                 C3HC4-type 
                   
                   
                   
                   
               
               
                   
                   
                 zinc finger 
                   
                   
                   
                   
               
               
                   
                   
                 containing 1 
                   
                   
                   
                   
               
               
                 203258_at 
                 NM_006442 
                 DR1-associated 
                 DRAP1 
                 1.6E−04 
                 −2.1 
                 5.1E−04 
               
               
                   
                   
                 protein 1 
                   
                   
                   
                   
               
               
                   
                   
                 (negative 
                   
                   
                   
                   
               
               
                   
                   
                 cofactor 2 alpha) 
                   
                   
                   
                   
               
               
                 201360_at 
                 NM_000099 
                 cystatin C 
                 CST3 
                 6.0E−04 
                 −2.1 
                 4.6E−04 
               
               
                   
                   
                 (amyloid 
                   
                   
                   
                   
               
               
                   
                   
                 angiopathy and 
                   
                   
                   
                   
               
               
                   
                   
                 cerebral 
                   
                   
                   
                   
               
               
                   
                   
                 hemorrhage) 
                   
                   
                   
                   
               
               
                 200709_at 
                 NM_000801 
                 FK506 binding 
                 FKBP1A 
                 8.6E−06 
                 −2.0 
                 9.5E−05 
               
               
                   
                   
                 protein 1A, 
                   
                   
                   
                   
               
               
                   
                   
                 12 kDa 
                   
                   
                   
                   
               
               
                 218109_s_at 
                 NM_022736 
                 major facilitator 
                 MFSD1 
                 2.9E−04 
                 −2.0 
                 4.0E−04 
               
               
                   
                   
                 superfamily 
                   
                   
                   
                   
               
               
                   
                   
                 domain 
                   
                   
                   
                   
               
               
                   
                   
                 containing 1 
                   
                   
                   
                   
               
               
                 203454_s_at 
                 NM_004045 
                 ATX1 
                 ATOX1 
                 6.3E−05 
                 −2.0 
                 3.3E−04 
               
               
                   
                   
                 antioxidant 
                   
                   
                   
                   
               
               
                   
                   
                 protein 1 
                   
                   
                   
                   
               
               
                   
                   
                 homolog (yeast) 
               
               
                   
               
               
                 The genes were selected by two statistic analyses: t-test (p &lt; 0.001 and 2 fold between the groups of 15 sensitive cell lines and 14 resistant cell lines) and the Pearson correlations between the log2 (IC 50 ) data and the expression level of each gene in the 29 cell lines (p &lt; 0.001). 
               
               
                 The overlapped genes listed here with p values and fold change indicated. 
               
               
                 The genes are rank ordered by the fold changes. 
               
               
                 The positive fold changes indicate the genes have higher expression level in the sensitive cell lines and the negative fold changes indicate the genes have higher expression level in the resistant cell lines. 
               
             
          
         
       
     
     The same two statistical methods were applied to protein profiling data to identify proteins that correlated with the sensitivity of the cell lines to IGF1R inhibitors. This yielded 251 unique peptide ions for compound 1, and 228 unique peptide ions for compound 2, 153 of which overlap between the two compounds. These unique peptide ions were then sequenced by tandem mass spectrometry to obtain the identity of the corresponding protein markers. As shown in Table 4, 76 peptides were identified to represent 46 proteins that were differentially expressed between the sensitive and resistant cell line groups for compound 1; and 70 peptides representing 45 proteins (Table 5) for compound 2, with 39 proteins common for both compounds. 
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Proteins correlated with the sensitivity of 26 sarcoma cell lines to 
               
               
                 compound 1 as identified by LC/MS based protein profiling. 
               
             
          
           
               
                   
                 Swiss- 
                 Identified 
                   
                   
               
               
                   
                 protein 
                 by 
                 Gene 
                   
               
               
                 Protein name 
                 ID 
                 microarray 
                 name 
                 Peptide sequence 
               
               
                   
               
               
                 actinin, alpha 
                 P12814 
                 Yes 
                 ACTN1 
                 VGWEQLLTTIAR (SEQ ID NO: 1) 
               
               
                   
                   
                   
                   
                 FAIQDISVEETSAK (SEQ ID NO: 2) 
               
               
                   
                   
                   
                   
                 TINEVENQILTR (SEQ ID NO: 3) 
               
               
                 actinin, alpha 
                 O43707 
                 Yes 
                 ACTN4 
                 DYETATLSDIK (SEQ ID NO: 4) 
               
               
                 AHNAK 
                 Q09666 
                 Yes 
                 AHNAK 
                 VPGIDATTK (SEQ ID NO: 5) 
               
               
                 nucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 GEGPEVDVNLPK (SEQ ID NO: 6) 
               
               
                   
                   
                   
                   
                 FSMPGFK (SEQ ID NO: 7) 
               
               
                   
                   
                   
                   
                 IGFSGPKLEGGEVDLKGPK (SEQ ID NO: 8 
               
               
                   
                   
                   
                   
                 ISMPDFDLHLK (SEQ ID NO: 9 
               
               
                   
                   
                   
                   
                 ISMPDIDLNLK: (SEQ ID NO: 10) 
               
               
                   
                   
                   
                   
                 GEGPDVHMTLPKGDISISGPK (SEQ ID NO: 11) 
               
               
                 Plasma 
                 P23634 
                   
                 ATP2B4 
                 SMSTVIRNPNGGFR (SEQ ID NO: 12) 
               
               
                 membrane 
                   
                   
                   
                   
               
               
                 calcium- 
                   
                   
                   
                   
               
               
                 transporting 
                   
                   
                   
                   
               
               
                 ATPase 4 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 TSPVEGLSGNPADLEK (SEQ ID NO: 13) 
               
               
                   
                   
                   
                   
                 PADGILIQGNDLK (SEQ ID NO: 14) 
               
               
                 ATP synthase, 
                 Q9Y653 
                 Yes 
                 ATP5G 
                 TIAMDGTEGLVR (SEQ ID NO: 15) 
               
               
                 H+ transporting, 
                   
                   
                   
                   
               
               
                 mitochondrial F1 
                   
                   
                   
                   
               
               
                 complex 
                   
                   
                   
                   
               
               
                 calpain 
                   
                   
                 CAPN2 
                 SMVAVMDSDTTGK (SEQ ID NO: 16) 
               
               
                 Creatine Kinase, 
                   
                 Yes 
                 CKB 
                 FCTGLTQIETLFK (SEQ ID NO: 17) 
               
               
                 brain 
                   
                   
                   
                   
               
               
                 chloride 
                 O00299 
                 Yes 
                 CLIC1 
                 GVTFNVTTVDTK (SEQ ID NO: 18) 
               
               
                 intracelluar 
                   
                   
                   
                   
               
               
                 protein 1 
                   
                   
                   
                   
               
               
                 heat shock 
                   
                   
                 CPN60 
                 VGEVIVTK (SEQ ID NO: 19) 
               
               
                 protein 60 
                   
                   
                   
                   
               
               
                 catenin 
                   
                 Yes 
                 CTNNA1 
                 TLAVER (SEQ ID NO: 20) 
               
               
                   
                   
                   
                   
                 HVNPVQALSEFK (SEQ ID NO: 21) 
               
               
                 destrin 
                 P60981 
                 Yes 
                 DSTN 
                 YALYDASFETK (SEQ ID NO: 22) 
               
               
                 myoferlin 
                 Q9NZM1 
                 Yes 
                 FER1L3 
                 VGETIIDLENR (SEQ ID NO: 23) 
               
               
                 filamin B 
                   
                 Yes 
                 FLNB 
                 GDYVLAVK (SEQ ID NO: 24) 
               
               
                 G protein- 
                   
                 Yes 
                 GPR56 
                 SSLHYKPTPDLR (SEQ ID NO: 25) 
               
               
                 coupled receptor 
                   
                   
                   
                   
               
               
                 56 
                   
                   
                   
                   
               
               
                 histone 2 
                   
                 Yes 
                 H2AFY2 
                 EIQTAVR (SEQ ID NO: 26) 
               
               
                 histone 3 
                   
                 Yes 
                 H3F3B 
                 EIAQDFK (SEQ ID NO: 27) 
               
               
                 histone 1 
                   
                   
                 HIST1H4I 
                 TLYGFGG (SEQ ID NO: 28) 
               
               
                   
                   
                   
                   
                 DAVTYTEHAK (SEQ ID NO: 29) 
               
               
                 histone 3 
                   
                 Yes 
                 HIST3H3 
                 YRPGTVALR (SEQ ID NO: 30) 
               
               
                 high mobility 
                   
                   
                 HMGB1 
                 KHPDASVNFSEFSK (SEQ ID NO: 31) 
               
               
                 protein 1 
                   
                   
                   
                   
               
               
                 high mobility 
                 P26583 
                 Yes 
                 HMGB2 
                 LGEMWSEQSAK (SEQ ID NO: 32) 
               
               
                 protein 2 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 MSSYAFFVQTCR (SEQ ID NO: 33) 
               
               
                 heterogeneous 
                   
                 Yes 
                 HNRPA2 
                 IDTIEIITDR (SEQ ID NO: 34) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                   
                 Yes 
                 HNRPA3 
                 LTDCVVMR (SEQ ID NO: 35) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                 Q14103 
                 Yes 
                 HNRPD 
                 IFVGGLSPDTPEEK (SEQ ID NO: 36) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                 P09651 
                 Yes 
                 HRNPA1 
                 NQGGYGGSSSSSSYGSGR (SEQ ID NO: 37) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 EDSQRPGAHLTVK (SEQ ID NO: 38) 
               
               
                 heterogeneous 
                 P22626 
                 Yes 
                 HRNPA2 
                 GFGFVTFDDHDPVDK (SEQ ID NO: 39) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                 Q14103 
                 Yes 
                 HNRPD 
                 MFIGGLSWDTTK (SEQ ID NO: 40) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 GFGFVLFK (SEQ ID NO: 41) 
               
               
                 heterogeneous 
                   
                 Yes 
                 HRNPK 
                 IILDLISESPIK (SEQ ID NO: 42) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                   
                 Yes 
                 HRNPM 
                 AFITNIPFDVK (SEQ ID NO: 43) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 KH domain 
                 Q07666 
                 Yes 
                 KHDRBS1 
                 DSLDPSFTHAMQLLTAEIEK (SEQ ID NO: 44) 
               
               
                 containing, RNA 
                   
                   
                   
                   
               
               
                 binding, signal 
                   
                   
                   
                   
               
               
                 transduction 
                   
                   
                   
                   
               
               
                 associated 1 
                   
                   
                   
                   
               
               
                 LIM domain and 
                 Q9UHB6 
                   
                 LIMA1 
                 YPHIKDGEDLK (SEQ ID NO: 45) 
               
               
                 actin binding 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 SNTENLSQHFR (SEQ ID NO: 46) 
               
               
                 matrin 3 
                   
                 Yes 
                 MATR3 
                 MKSQAFIEMETR (SEQ ID NO: 47) 
               
               
                   
                   
                   
                   
                 YQLLQLVEPFGVISNHLILNK (SEQ ID NO: 48) 
               
               
                   
                   
                   
                   
                 DLSAAGIGLLAAATQSLSMPASLGR (SEQ ID NO: 49) 
               
               
                 myosin heavy 
                   
                 Yes 
                 MYH9 
                 VVFQEFR (SEQ ID NO: 50) 
               
               
                 chain 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 LQQELDDLLVDLDHQR (SEQ ID NO: 51) 
               
               
                   
                   
                   
                   
                 VISGVLQLGNIVFK (SEQ ID NO: 52) 
               
               
                   
                   
                   
                   
                 LDPHLVLDQLR (SEQ ID NO: 53) 
               
               
                 myosin light 
                 O00159 
                 Yes 
                 MYL6 
                 HVLVTLGEK (SEQ ID NO: 54) 
               
               
                 chain 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 ELLTTMGDR (SEQ ID NO: 55) 
               
               
                   
                   
                   
                   
                 EAFQLFDR (SEQ ID NO: 56) 
               
               
                   
                   
                   
                   
                 DGFIDKEDLHDMLASLGK (SEQ ID NO: 57) 
               
               
                   
                   
                   
                   
                 IAEFTTNLTEEEEK (SEQ ID NO: 58) 
               
               
                   
                   
                   
                   
                 VLDFEHFLPMLQTVAK (SEQ ID NO: 59) 
               
               
                 lactate 
                   
                   
                 LDHB 
                 IVVVTAGVR (SEQ ID NO: 60) 
               
               
                 dehydrogenase 
                   
                   
                   
                   
               
               
                 histone H2B 
                   
                 Yes 
                 NP_00351 
                 AMGIMNSFVNDIFER (SEQ ID NO: 61) 
               
               
                 tublin, alpha 
                   
                   
                 NP_006073 
                 FDLMYAK (SEQ ID NO: 62) 
               
               
                 cleavage and 
                 Q10570 
                 Yes 
                 CPSF1 
                 MYAVYK (SEQ ID NO: 63) 
               
               
                 polyadenylation 
                   
                   
                   
                   
               
               
                 specific factor 1 
                   
                   
                   
                   
               
               
                 poly rC binding 
                   
                 Yes 
                 PCBP2 
                 IITLTGPTNAIFK (SEQ ID NO: 64) 
               
               
                 protein 
                   
                   
                   
                   
               
               
                 peroxiredoxin 
                   
                 Yes 
                 PRDX6 
                 LPFPIIDDR (SEQ ID NO: 65) 
               
               
                 protein tyrosine 
                   
                   
                 PTPRF 
                 TFALHK (SEQ ID NO: 66) 
               
               
                 phosphatase, 
                   
                   
                   
                   
               
               
                 receptor type, F 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 YANVIAYDHSR (SEQ ID NO: 67) 
               
               
                 Radixin 
                 P35241 
                   
                 RDX 
                 KALELDQER (SEQ ID NO: 68) 
               
               
                   
                   
                   
                   
                 KENPLQFKFR (SEQ ID NO: 69) 
               
               
                 splicing factor 
                   
                   
                 SFPQ 
                 LFVGNLPADITEDEFKR (SEQ ID NO: 70) 
               
               
                 proline/glutamine 
                   
                   
                   
                   
               
               
                 rich 
                   
                   
                   
                   
               
               
                 spectrin, beta 
                   
                   
                 SPTBN2 
                 ALAVEGK (SEQ ID NO: 71) 
               
               
                   
                   
                   
                   
                 AAMRETWLSENQR (SEQ ID NO: 72) 
               
               
                 Stathmin 
                 P16949 
                 Yes 
                 STMN1 
                 DLSLEEIQK (SEQ ID NO: 73) 
               
               
                 Syntaxin 
                 O15400 
                 Yes 
                 STX7 
                 TLNQLGTPQDSPELR (SEQ ID NO: 74) 
               
               
                 thymoprotein 
                   
                   
                 TMPO 
                 YGVNPGPIVGTTR (SEQ ID NO: 75) 
               
               
                   
               
               
                 The peptide ions were selected by the overlaps between the two statistic analyses: t-test (p &lt; 0.001 and 2 fold between the groups of 14 sensitive cell lines and 12 resistant cell lines) and the Pearson correlations between the log2(IC 50 ) data and the expression level of each peptide ion in the 26 cell lines (p &lt; 0.001). 
               
               
                 The peptide ions generated from statistical analyses were sequenced by tandem mass spectrometry to get the identification of the proteins which are listed in this Table. 
               
               
                 The name of protein and gene, the sequence of each peptide ion associated with identified protein are listed. 
               
               
                 The overlap with Affymetrix gene expression results also indicated. 
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 Proteins correlated with the sensitivity of 27 sarcoma cell lines to 
               
               
                 compound 2 as identified by LC/MS based protein profiling. 
               
             
          
           
               
                   
                 Swiss- 
                 Identified 
                   
                   
               
               
                   
                 protein 
                 by 
                 Gene 
                   
               
               
                 Protein name 
                 ID 
                 microarray 
                 name 
                 Peptide sequence 
               
               
                   
               
               
                 Septin 7 
                 Q16181 
                   
                 SEPT7 
                 IKIYEFPETDDEEENKLVK (SEQ ID NO: 76) 
               
               
                 actinin, alpha 
                 P12814 
                 Yes 
                 ACTN1 
                 VGWEQLLTTIAR (SEQ ID NO: 77) 
               
               
                   
                   
                   
                   
                 FAIQDISVEETSAK (SEQ ID NO: 78) 
               
               
                   
                   
                   
                   
                 TINEVENQILTR (SEQ ID NO: 79) 
               
               
                   
                   
                   
                   
                 RDQALTEEHAR (SEQ ID NO: 80) 
               
               
                 actinin, alpha 
                 O43707 
                 Yes 
                 ACTN4 
                 DYETATLSDIK (SEQ ID NO: 81) 
               
               
                   
                   
                   
                   
                 ISNRPAFMPSEGK (SEQ ID NO: 82) 
               
               
                 AHNAK 
                 Q09666 
                 Yes 
                 AHNAK 
                 VPGIDATTK (SEQ ID NO: 83) 
               
               
                 nucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 GEGPEVDVNLPK (SEQ ID NO: 84) 
               
               
                   
                   
                   
                   
                 FSMPGFK (SEQ ID NO: 85) 
               
               
                   
                   
                   
                   
                 IGFSGPKLEGGEVDLKGPK (SEQ ID NO: 86) 
               
               
                   
                   
                   
                   
                 ISMPDFDLHLK (SEQ ID NO: 87) 
               
               
                   
                   
                   
                   
                 ISMPDIDLNLK (SEQ ID NO: 88) 
               
               
                   
                   
                   
                   
                 GEGPDVHMTLPKGDISISGPK (SEQ ID NO: 89) 
               
               
                   
                   
                   
                   
                 GDLDASVPSMK (SEQ ID NO: 90) 
               
               
                 Plasma 
                 P23634 
                   
                 ATP2B4 
                 TSPVEGLSGNPADLEK (SEQ ID NO: 91) 
               
               
                 membrane 
                   
                   
                   
                   
               
               
                 calcium- 
                   
                   
                   
                   
               
               
                 transporting 
                   
                   
                   
                   
               
               
                 ATPase 4 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 PADGILIQGNDLK (SEQ ID NO: 92) 
               
               
                 ATP synthase, 
                 Q9Y653 
                 Yes 
                 ATP5G 
                 TIAMDGTEGLVR (SEQ ID NO: 93) 
               
               
                 H+ 
                   
                   
                   
                   
               
               
                 transporting, 
                   
                   
                   
                   
               
               
                 mitochondrial 
                   
                   
                   
                   
               
               
                 F1 complex 
                   
                   
                   
                   
               
               
                 Creatine 
                   
                 Yes 
                 CKB 
                 FCTGLTQIETLFK (SEQ ID NO: 94) 
               
               
                 Kinase, brain 
                   
                   
                   
                   
               
               
                 chloride 
                 O00299 
                 Yes 
                 CLIC1 
                 GVTFNVTTVDTK (SEQ ID NO: 95) 
               
               
                 intracelluar 
                   
                   
                   
                   
               
               
                 protein 1 
                   
                   
                   
                   
               
               
                 catenin 
                   
                 Yes 
                 CTNNA1 
                 HVNPVQALSEFK (SEQ ID NO: 96) 
               
               
                 destrin 
                 P60981 
                 Yes 
                 DSTN 
                 YALYDASFETK (SEQ ID NO: 97) 
               
               
                 myoferlin 
                 Q9NZM1 
                 Yes 
                 FER1L3 
                 VGETIIDLENR (SEQ ID NO: 98) 
               
               
                 filamin B 
                   
                 Yes 
                 FLNB 
                 GDYVLAVK (SEQ ID NO: 99) 
               
               
                 G protein- 
                   
                 Yes 
                 GPR56 
                 SSLHYKPTPDLR (SEQ ID NO: 100) 
               
               
                 coupled 
                   
                   
                   
                   
               
               
                 receptor 56 
                   
                   
                   
                   
               
               
                 histone 2 
                 Q99877 
                 Yes 
                 H2AFY2 
                 ESYSVYVYK (SEQ ID NO: 101) 
               
               
                 histone 3 
                   
                 Yes 
                 HIST3H3 
                 YRPGTVALR (SEQ ID NO: 102) 
               
               
                 high mobility 
                   
                   
                 HMGB1 
                 KHPDASVNFSEFSK (SEQ ID NO: 103) 
               
               
                 protein 1 
                   
                   
                   
                   
               
               
                 high mobility 
                   
                 Yes 
                 HMGB2 
                 MSSYAFFVQTCR (SEQ ID NO: 104) 
               
               
                 protein 2 
                   
                   
                   
                   
               
               
                 heterogeneous 
                   
                 Yes 
                 HNRPA3 
                 LTDCVVMR (SEQ ID NO: 105) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                 P09651 
                 Yes 
                 HRNPA1 
                 NQGGYGGSSSSSSYGSGR (SEQ ID NO: 106) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 EDSQRPGAHLTVK (SEQ ID NO: 107) 
               
               
                 heterogeneous 
                   
                 Yes 
                 HRNPA2 
                 GFGFVTFDDHDPVDK (SEQ ID NO: 108) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                 Q14103 
                 Yes 
                 HRNPD 
                 GFGFVLFK (SEQ ID NO: 109) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                   
                 Yes 
                 HRNPK 
                 IILDLISESPIK (SEQ ID NO: 110) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 heterogeneous 
                   
                 Yes 
                 HRNPM 
                 AFITNIPFDVK (SEQ ID NO: 111) 
               
               
                 nuclear 
                   
                   
                   
                   
               
               
                 ribonucleoprotein 
                   
                   
                   
                   
               
               
                 KH domain 
                 Q07666 
                 Yes 
                 KHDRBS1 
                 DSLDPSFTHAMQLLTAEIEK (SEQ ID NO: 112) 
               
               
                 containing, 
                   
                   
                   
                   
               
               
                 RNA binding, 
                   
                   
                   
                   
               
               
                 signal 
                   
                   
                   
                   
               
               
                 transduction 
                   
                   
                   
                   
               
               
                 associated 1 
                   
                   
                   
                   
               
               
                 LIM domain 
                 Q9UHB6 
                   
                 LIMA1 
                 YPHIKDGEDLK (SEQ ID NO: 113) 
               
               
                 and actin 
                   
                   
                   
                   
               
               
                 binding 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 SNTENLSQHFR (SEQ ID NO: 114) 
               
               
                 matrin 3 
                   
                 Yes 
                 MATR3 
                 MKSQAFIEMETR (SEQ ID NO: 115) 
               
               
                   
                   
                   
                   
                 YQLLQLVEPFGVISNHLILNK (SEQ ID NO: 116) 
               
               
                   
                   
                   
                   
                 DLSAAGIGLLAAATQSLSMPAS 
               
               
                   
                   
                   
                   
                 LGR (SEQ ID NO: 117) 
               
               
                 myosin heavy 
                   
                 Yes 
                 MYH9 
                 VVFQEFR (SEQ ID NO: 118) 
               
               
                 chain 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 LQQELDDLLVDLDHQR (SEQ ID NO: 119) 
               
               
                   
                   
                   
                   
                 VISGVLQLGNIVFK (SEQ ID NO: 120) 
               
               
                   
                   
                   
                   
                 LDPHLVLDQLR (SEQ ID NO: 121) 
               
               
                   
                   
                   
                   
                 IVGLDQVTGMTETAFGSAYK (SEQ ID NO: 122) 
               
               
                 myosin light 
                 O00159 
                 Yes 
                 MYL6 
                 HVLVTLGEK (SEQ ID NO: 123) 
               
               
                 chain 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 EAFQLFDR (SEQ ID NO: 124) 
               
               
                 lactate 
                 P07195 
                   
                 LDHB 
                 IVVVTAGVR (SEQ ID NO: 125) 
               
               
                 dehydrogenase 
                   
                   
                   
                   
               
               
                 histone H2B 
                   
                 Yes 
                 NP_00351 
                 AMGIMNSFVNDIFER (SEQ ID NO: 126) 
               
               
                 Annexin A2 
                 P07355 
                 Yes 
                 ANXA2 
                 TPAQYDASELK (SEQ ID NO: 127) 
               
               
                 Clathrin heavy 
                 Q00610 
                 Yes 
                 CLTC 
                 IVLDNSVFSEHR (SEQ ID NO: 128) 
               
               
                 chain 1 
                   
                   
                   
                   
               
               
                 tublin, alpha 
                 P68363 
                   
                 NP_006073 
                 FDLMYAK (SEQ ID NO: 129) 
               
               
                   
                   
                   
                   
                 LDHKFDLMYAK (SEQ ID NO: 130) 
               
               
                 calcium 
                 Q99653 
                   
                 NP_009167 
                 ETGFSHSQITR (SEQ ID NO: 131) 
               
               
                 binding 
                   
                   
                   
                   
               
               
                 protein P22 
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 ISRDELLQVLR (SEQ ID NO: 132) 
               
               
                 cleavage and 
                 Q10570 
                 Yes 
                 CPSF1 
                 MYAVYK (SEQ ID NO: 133) 
               
               
                 polyadenylation 
                   
                   
                   
                   
               
               
                 specific 
                   
                   
                   
                   
               
               
                 factor 1 
                   
                   
                   
                   
               
               
                 poly rC 
                   
                 Yes 
                 PCBP2 
                 IITLTGPTNAIFK (SEQ ID NO: 134) 
               
               
                 binding 
                   
                   
                   
                   
               
               
                 protein 
                   
                   
                   
                   
               
               
                 peroxiredoxin 
                 P30041 
                 Yes 
                 PRDX6 
                 LPFPIIDDR (SEQ ID NO: 135) 
               
               
                 protein 
                   
                   
                 PTPRF 
                 YANVIAYDHSR (SEQ ID NO: 136) 
               
               
                 tyrosine 
                   
                   
                   
                   
               
               
                 phosphatase, 
                   
                   
                   
                   
               
               
                 receptor type, F 
                   
                   
                   
                   
               
               
                 Radixin 
                 P35241 
                   
                 RDX 
                 KALELDQER (SEQ ID NO: 137) 
               
               
                   
                   
                   
                   
                 KENPLQFK (SEQ ID NO: 138) 
               
               
                 splicing factor 
                   
                   
                 SFPQ 
                 LFVGNLPADITEDEFKR (SEQ ID NO: 139) 
               
               
                 proline/glutamine 
                   
                   
                   
                   
               
               
                 rich 
                   
                   
                   
                   
               
               
                 spectrin, beta 
                 O15020 
                   
                 SPTBN2 
                 VGDLYSDLRDGR (SEQ ID NO: 140) 
               
               
                   
                   
                   
                   
                 AAMRETWLSENQR (SEQ ID NO: 141) 
               
               
                 Stathmin 
                 P16949 
                 Yes 
                 STMN1 
                 DLSLEEIQK (SEQ ID NO: 142) 
               
               
                 Syntaxin 
                 O15400 
                 Yes 
                 STX7 
                 TLNQLGTPQDSPELR (SEQ ID NO: 143) 
               
               
                 thymoprotein 
                   
                   
                 TMPO 
                 YGVNPGPIVGTTR (SEQ ID NO: 144) 
               
               
                 Tubulin beta-2 
                 P05217 
                 Yes 
                 TUBB2C 
                 EIVHIQAGQCGNQIGAK (SEQ ID NO: 145) 
               
               
                 chain 
               
               
                   
               
               
                 The peptide ions were selected by the overlaps between the two statistic analyses: t-test (p &lt; 0.001 and 2 fold between the groups of 13 sensitive cell lines and 14 resistant cell lines) and the Pearson correlations between the log2(IC 50 ) data and the expression level of each peptide ion in the 27 cell lines (p &lt; 0.001). 
               
               
                 The peptide ions generated from statistical analyses were sequenced by tandem mass spectrometry to get the identification of the proteins which are listed in this Table. 
               
               
                 The name of protein and gene, the sequence of each peptide ion associated with identified protein are listed. 
               
               
                 The overlap with Affymetrix gene expression results also indicated. 
               
             
          
         
       
     
     In general, a higher number of genes than proteins was identified using the same statistic analyses due to the complicity of the protein profiling technology. Cross comparing the gene and protein profiling results, the overlaps between identified genes and proteins are significantly large as indicated in Tables 4 and 5. 71.7% (33 out 46) proteins for compound 1 and 73.3% (33 out 45) proteins for compound 2 also identified in gene expression profiling, respectively, suggesting good concordance between the results detected by the two technologies. For some of the markers identified by the protein profiling, for example, ATP2B4, it was also detected as significantly differentially expressed between the sensitive and resistant cell lines (−2.3 fold and p values are 0.0043 and 0.0016 for t-test and correlation test, respectively) by gene profiling, yet did not meet the stringent statistical cutoff of p values of 0.001. 
     Genes/Proteins Modulated by IGF1R Inhibitor Compound 1 Treatment: 
     There is differential sensitivity of compound 1 in a pair of human RMS cell lines, Rh36 (resistant, IC 50 =1.6 μM) and Rh41 (sensitive, IC 50 =0.069 μM). In order to understand the mechanism of the differential sensitivity, both cell lines were evaluated using gene expression profiling and proteomics analyses to search at genomics scale for genes or proteins that are differentially modulated by IGF1R inhibitor compound 1 in a time course study with the drug treatment for 6, 30 and 72 hours. Cell lysates were subjected in parallel to microarray and LC/MS based “bottom-up” protein profiling analyses. A two-way ANOVA mixed model was utilized to identify drug treatment effect as well as treatment and time interaction on the expression of genes and protein. Overall, there were some mRNA transcripts or peptides with expression change upon the drug treatment in Rh36 cell line at 6 hr, and these changes mainly reflected the initial stress response to the stimuli the cell encountered. However, the drug had little to no effect at later time points, 36 and 72 hrs in Rh36 cells. This makes sense for the given concentration of compound 1 cell treated, Rh36 is highly resistant, so the drug had little effect on cell growth compared to the sensitive cell Rh41, which had dramatic changes in gene/protein expression. The genes and protein that were modulated by compound 1 in the sensitive RH41 cell line are listed in Table 6 and Table 7, respectively. 
     
       
         
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
             
             
               
                   
               
               
                 Genes modulated by compound 1 treatment in Rh41 cells. 
               
             
          
           
               
                   
                   
                   
                   
                   
                 fdr p 
                 fold_change 
               
               
                   
                   
                 Gene 
                   
                 fdr p value 
                 value for 
                 (compound 
               
               
                 probe 
                 Accession # 
                 Symbol 
                 Gene Title 
                 for treatment 
                 treatment_Time 
                 1 vs DMSO) 
               
               
                   
               
             
          
           
               
                 213880_at 
                 AL524520 
                 LGR5 
                 leucine-rich repeat- 
                 0.0007 
                 0.9280 
                 3.5 
               
               
                   
                   
                   
                 containing G 
                   
                   
                   
               
               
                   
                   
                   
                 protein-coupled 
                   
                   
                   
               
               
                   
                   
                   
                 receptor 5 
                   
                   
                   
               
               
                 203131_at 
                 NM_006206 
                 PDGFRA 
                 platelet-derived 
                 0.0011 
                 0.6916 
                 3.3 
               
               
                   
                   
                   
                 growth factor 
                   
                   
                   
               
               
                   
                   
                   
                 receptor, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 
                   
                   
                   
               
               
                 219106_s_at 
                 NM_006063 
                 KBTBD10 
                 kelch repeat and 
                 0.0007 
                 0.0666 
                 2.6 
               
               
                   
                   
                   
                 BTB (POZ) 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 
                   
                   
                   
               
               
                   
                   
                   
                 10 
                   
                   
                   
               
               
                 207558_s_at 
                 NM_000325 
                 PITX2 
                 paired-like 
                 0.0130 
                 0.8149 
                 2.3 
               
               
                   
                   
                   
                 homeodomain 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 2 
                   
                   
                   
               
               
                 212614_at 
                 BG285011 
                 ARID5B 
                 AT rich interactive 
                 0.0005 
                 0.2446 
                 2.3 
               
               
                   
                   
                   
                 domain 5B 
                   
                   
                   
               
               
                   
                   
                   
                 (MRF1-like) 
                   
                   
                   
               
               
                 214375_at 
                 AI962377 
                 PPFIBP1 
                 PTPRF interacting 
                 0.0030 
                 0.0721 
                 2.2 
               
               
                   
                   
                 /// 
                 protein, binding 
                   
                   
                   
               
               
                   
                   
                 LOC440091 
                 protein 1 (liprin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 beta 1) /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC729222 
                 Liprin-beta 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Protein tyrosine 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatase 
                   
                   
                   
               
               
                   
                   
                   
                 receptor type f 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide- 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 1) 
                   
                   
                   
               
               
                   
                   
                   
                 (PTPRF-interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1) (hSGT2) 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 PTPRF interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 isoform 1 
                   
                   
                   
               
               
                 209102_s_at 
                 AF019214 
                 HBP1 
                 HMG-box 
                 0.0004 
                 0.0424 
                 2.2 
               
               
                   
                   
                   
                 transcription factor 1 
                   
                   
                   
               
               
                 216321_s_at 
                 X03348 
                 NR3C1 
                 nuclear receptor 
                 0.0059 
                 0.2261 
                 2.1 
               
               
                   
                   
                   
                 subfamily 3, group 
                   
                   
                   
               
               
                   
                   
                   
                 C, member 1 
                   
                   
                   
               
               
                   
                   
                   
                 (glucocorticoid 
                   
                   
                   
               
               
                   
                   
                   
                 receptor) 
                   
                   
                   
               
               
                 209199_s_at 
                 N22468 
                 MEF2C 
                 MADS box 
                 0.0022 
                 0.2701 
                 2.1 
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 enhancer factor 2, 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide C 
                   
                   
                   
               
               
                   
                   
                   
                 (myocyte enhancer 
                   
                   
                   
               
               
                   
                   
                   
                 factor 2C) 
                   
                   
                   
               
               
                 202364_at 
                 NM_005962 
                 MXI1 
                 MAX interactor 1 
                 0.0014 
                 0.4787 
                 2.0 
               
               
                   
                   
                   
                 /// MAX interactor 1 
                   
                   
                   
               
               
                 213624_at 
                 AA873600 
                 SMPDL3A 
                 sphingomyelin 
                 0.0027 
                 0.5082 
                 2.0 
               
               
                   
                   
                   
                 phosphodiesterase, 
                   
                   
                   
               
               
                   
                   
                   
                 acid-like 3A 
                   
                   
                   
               
               
                 218258_at 
                 NM_015972 
                 POLR1D 
                 polymerase (RNA) 
                 0.0006 
                 0.0546 
                 2.0 
               
               
                   
                   
                   
                 I polypeptide D, 
                   
                   
                   
               
               
                   
                   
                   
                 16 kDa 
                   
                   
                   
               
               
                 220416_at 
                 NM_024837 
                 ATP8B4 
                 ATPase, Class I, 
                 0.0056 
                 0.4286 
                 2.0 
               
               
                   
                   
                   
                 type 8B, member 4 
                   
                   
                   
               
               
                 212148_at 
                 AL049381 
                 PBX1 
                 Pre-B-cell 
                 0.0024 
                 0.5563 
                 2.0 
               
               
                   
                   
                   
                 leukemia 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 1 
                   
                   
                   
               
               
                 205923_at 
                 NM_005045 
                 RELN 
                 reelin 
                 0.0020 
                 0.3396 
                 2.0 
               
               
                 213891_s_at 
                 AI927067 
                 — 
                 CDNA FLJ11918 
                 0.0029 
                 0.3970 
                 2.0 
               
               
                   
                   
                   
                 fis, clone 
                   
                   
                   
               
               
                   
                   
                   
                 HEMBB1000272 
                   
                   
                   
               
               
                 206306_at 
                 NM_001036 
                 RYR3 
                 ryanodine receptor 3 
                 0.0014 
                 0.2488 
                 1.9 
               
               
                 214608_s_at 
                 AJ000098 
                 EYA1 
                 eyes absent 
                 0.0007 
                 0.0714 
                 1.9 
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 221217_s_at 
                 NM_018723 
                 A2BP1 
                 ataxin 2-binding 
                 0.0015 
                 0.0721 
                 1.9 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 213593_s_at 
                 AW978896 
                 TRA2A 
                 transformer-2 
                 0.0153 
                 0.4675 
                 1.9 
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 203628_at 
                 H05812 
                 IGF1R 
                 insulin-like growth 
                 0.0017 
                 0.0401 
                 1.9 
               
               
                   
                   
                   
                 factor 1 receptor 
                   
                   
                   
               
               
                 212406_s_at 
                 AB028973 
                 PCMTD2 
                 protein-L- 
                 0.0007 
                 0.5279 
                 1.9 
               
               
                   
                   
                   
                 isoaspartate (D- 
                   
                   
                   
               
               
                   
                   
                   
                 aspartate) O- 
                   
                   
                   
               
               
                   
                   
                   
                 methyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 213139_at 
                 AI572079 
                 SNAI2 
                 snail homolog 2 
                 0.0064 
                 0.3069 
                 1.9 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 215123_at 
                 AL049250 
                 LOC23117 
                 KIAA0220-like 
                 0.0116 
                 0.4345 
                 1.9 
               
               
                   
                   
                 /// 
                 protein /// 
                   
                   
                   
               
               
                   
                   
                 LOC339047 
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein 
                   
                   
                   
               
               
                   
                   
                 LOC642778 
                 LOC339047 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 similar to nuclear 
                   
                   
                   
               
               
                   
                   
                 LOC642799 
                 pore complex 
                   
                   
                   
               
               
                   
                   
                 /// 
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                 LOC728888 
                 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 nuclear pore 
                   
                   
                   
               
               
                   
                   
                   
                 complex 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Protein KIAA0220 
                   
                   
                   
               
               
                 220751_s_at 
                 NM_016348 
                 C5orf4 
                 chromosome 5 
                 0.0038 
                 0.3618 
                 1.9 
               
               
                   
                   
                   
                 open reading frame 4 
                   
                   
                   
               
               
                 205619_s_at 
                 NM_004527 
                 MEOX1 
                 mesenchyme 
                 0.0072 
                 0.1300 
                 1.8 
               
               
                   
                   
                   
                 homeobox 1 
                   
                   
                   
               
               
                 218694_at 
                 NM_016608 
                 ARMCX1 
                 armadillo repeat 
                 0.0021 
                 0.2291 
                 1.8 
               
               
                   
                   
                   
                 containing, X- 
                   
                   
                   
               
               
                   
                   
                   
                 linked 1 
                   
                   
                   
               
               
                 201739_at 
                 NM_005627 
                 SGK 
                 serum/glucocorticoid 
                 0.0025 
                 0.3263 
                 1.8 
               
               
                   
                   
                   
                 regulated kinase 
                   
                   
                   
               
               
                 221899_at 
                 AI809961 
                 PFAAP5 
                 Phosphonoformate 
                 0.0076 
                 0.5328 
                 1.8 
               
               
                   
                   
                   
                 immuno-associated 
                   
                   
                   
               
               
                   
                   
                   
                 protein 5 
                   
                   
                   
               
               
                 217989_at 
                 NM_016245 
                 HSD17B11 
                 hydroxysteroid 
                 0.0010 
                 0.2141 
                 1.8 
               
               
                   
                   
                   
                 (17-beta) 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 11 
                   
                   
                   
               
               
                 204030_s_at 
                 NM_014575 
                 SCHIP1 
                 schwannomin 
                 0.0019 
                 0.5363 
                 1.8 
               
               
                   
                   
                   
                 interacting protein 1 
                   
                   
                   
               
               
                 205741_s_at 
                 NM_001392 
                 DTNA 
                 dystrobrevin, alpha 
                 0.0038 
                 0.5200 
                 1.8 
               
               
                 203753_at 
                 NM_003199 
                 TCF4 
                 transcription factor 4 
                 0.0034 
                 0.0971 
                 1.8 
               
               
                 219961_s_at 
                 NM_018474 
                 C20orf19 
                 chromosome 20 
                 0.0043 
                 0.7121 
                 1.8 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 19 
                   
                   
                   
               
               
                 201384_s_at 
                 NM_005899 
                 NBR1 /// 
                 neighbor of 
                 0.0015 
                 0.8006 
                 1.8 
               
               
                   
                   
                 LOC727732 
                 BRCA1 gene 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to neighbor 
                   
                   
                   
               
               
                   
                   
                   
                 of BRCA1 gene 1 
                   
                   
                   
               
               
                 211341_at 
                 L20433 
                 POU4F1 
                 POU domain, class 
                 0.0030 
                 0.0990 
                 1.8 
               
               
                   
                   
                   
                 4, transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factor 1 
                   
                   
                   
               
               
                 203408_s_at 
                 NM_002971 
                 SATB1 
                 special AT-rich 
                 0.0011 
                 0.0695 
                 1.8 
               
               
                   
                   
                   
                 sequence binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 (binds to 
                   
                   
                   
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 matrix/scaffold- 
                   
                   
                   
               
               
                   
                   
                   
                 associating DNA&#39;s) 
                   
                   
                   
               
               
                 200632_s_at 
                 NM_006096 
                 NDRG1 
                 N-myc downstream 
                 0.0057 
                 0.0839 
                 1.7 
               
               
                   
                   
                   
                 regulated gene 1 
                   
                   
                   
               
               
                 204019_s_at 
                 NM_015677 
                 SH3YL1 
                 SH3 domain 
                 0.0079 
                 0.1130 
                 1.7 
               
               
                   
                   
                   
                 containing, Ysc84- 
                   
                   
                   
               
               
                   
                   
                   
                 like 1 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 207327_at 
                 NM_004100 
                 EYA4 
                 eyes absent 
                 0.0058 
                 0.1761 
                 1.7 
               
               
                   
                   
                   
                 homolog 4 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 213435_at 
                 AB028957 
                 SATB2 
                 SATB family 
                 0.0081 
                 0.5816 
                 1.7 
               
               
                   
                   
                   
                 member 2 
                   
                   
                   
               
               
                 219935_at 
                 NM_007038 
                 ADAMTS5 
                 ADAM 
                 0.0030 
                 0.0441 
                 1.7 
               
               
                   
                   
                   
                 metallopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 with 
                   
                   
                   
               
               
                   
                   
                   
                 thrombospondin 
                   
                   
                   
               
               
                   
                   
                   
                 type 1 motif, 5 
                   
                   
                   
               
               
                   
                   
                   
                 (aggrecanase-2) 
                   
                   
                   
               
               
                 209112_at 
                 BC001971 
                 CDKN1B 
                 cyclin-dependent 
                 0.0044 
                 0.2948 
                 1.7 
               
               
                   
                   
                   
                 kinase inhibitor 1B 
                   
                   
                   
               
               
                   
                   
                   
                 (p27, Kip1) 
                   
                   
                   
               
               
                 201294_s_at 
                 N24643 
                 WSB1 
                 WD repeat and 
                 0.0100 
                 0.1315 
                 1.7 
               
               
                   
                   
                   
                 SOCS box- 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 221589_s_at 
                 AW612403 
                 ALDH6A1 
                 aldehyde 
                 0.0135 
                 0.6528 
                 1.7 
               
               
                   
                   
                   
                 dehydrogenase 6 
                   
                   
                   
               
               
                   
                   
                   
                 family, member A1 
                   
                   
                   
               
               
                 209479_at 
                 BC000758 
                 CCDC28A 
                 coiled-coil domain 
                 0.0071 
                 0.2439 
                 1.7 
               
               
                   
                   
                   
                 containing 28A 
                   
                   
                   
               
               
                 200921_s_at 
                 NM_001731 
                 BTG1 
                 B-cell translocation 
                 0.0085 
                 0.7445 
                 1.7 
               
               
                   
                   
                   
                 gene 1, anti- 
                   
                   
                   
               
               
                   
                   
                   
                 proliferative 
                   
                   
                   
               
               
                 212179_at 
                 AW157501 
                 C6orf111 
                 chromosome 6 
                 0.0238 
                 0.4713 
                 1.7 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 111 
                   
                   
                   
               
               
                 203824_at 
                 NM_004616 
                 TSPAN8 
                 tetraspanin 8 
                 0.0167 
                 0.6494 
                 1.7 
               
               
                 204297_at 
                 NM_002647 
                 PIK3C3 
                 phosphoinositide- 
                 0.0051 
                 0.5000 
                 1.7 
               
               
                   
                   
                   
                 3-kinase, class 3 
                   
                   
                   
               
               
                 209185_s_at 
                 AF073310 
                 IRS2 
                 insulin receptor 
                 0.0021 
                 0.8649 
                 1.7 
               
               
                   
                   
                   
                 substrate 2 
                   
                   
                   
               
               
                 202551_s_at 
                 BG546884 
                 CRIM1 
                 cysteine rich 
                 0.0111 
                 0.1974 
                 1.7 
               
               
                   
                   
                   
                 transmembrane 
                   
                   
                   
               
               
                   
                   
                   
                 BMP regulator 1 
                   
                   
                   
               
               
                   
                   
                   
                 (chordin-like) 
                   
                   
                   
               
               
                 213782_s_at 
                 BF939176 
                 MYOZ2 
                 myozenin 2 
                 0.0121 
                 0.8529 
                 1.7 
               
               
                 212761_at 
                 AI949687 
                 TCF7L2 
                 transcription factor 
                 0.0012 
                 0.1631 
                 1.7 
               
               
                   
                   
                   
                 7-like 2 (T-cell 
                   
                   
                   
               
               
                   
                   
                   
                 specific, HMG- 
                   
                   
                   
               
               
                   
                   
                   
                 box) 
                   
                   
                   
               
               
                 202028_s_at 
                 BC000603 
                 RPL38 
                 ribosomal protein 
                 0.0118 
                 0.1143 
                 1.7 
               
               
                   
                   
                   
                 L38 
                   
                   
                   
               
               
                 207401_at 
                 NM_002763 
                 PROX1 
                 prospero-related 
                 0.0305 
                 0.2292 
                 1.7 
               
               
                   
                   
                   
                 homeobox 1 
                   
                   
                   
               
               
                 204851_s_at 
                 AF040254 
                 DCX 
                 doublecortex; 
                 0.0302 
                 0.0565 
                 1.7 
               
               
                   
                   
                   
                 lissencephaly, X- 
                   
                   
                   
               
               
                   
                   
                   
                 linked 
                   
                   
                   
               
               
                   
                   
                   
                 (doublecortin) 
                   
                   
                   
               
               
                 202553_s_at 
                 NM_015484 
                 SYF2 
                 SYF2 homolog, 
                 0.0015 
                 0.2787 
                 1.7 
               
               
                   
                   
                   
                 RNA splicing 
                   
                   
                   
               
               
                   
                   
                   
                 factor ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209034_at 
                 AF279899 
                 PNRC1 
                 proline-rich 
                 0.0093 
                 0.6717 
                 1.7 
               
               
                   
                   
                   
                 nuclear receptor 
                   
                   
                   
               
               
                   
                   
                   
                 coactivator 1 
                   
                   
                   
               
               
                 217906_at 
                 NM_014315 
                 KLHDC2 
                 kelch domain 
                 0.0017 
                 0.6814 
                 1.7 
               
               
                   
                   
                   
                 containing 2 
                   
                   
                   
               
               
                 208671_at 
                 AF164794 
                 SERINC1 
                 serine incorporator 1 
                 0.0044 
                 0.3841 
                 1.7 
               
               
                 206854_s_at 
                 NM_003188 
                 MAP3K7 
                 mitogen-activated 
                 0.0007 
                 0.0592 
                 1.6 
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase kinase 7 
                   
                   
                   
               
               
                 221841_s_at 
                 BF514079 
                 KLF4 
                 Kruppel-like factor 
                 0.0068 
                 0.1692 
                 1.6 
               
               
                   
                   
                   
                 4 (gut) 
                   
                   
                   
               
               
                 203810_at 
                 BG252490 
                 DNAJB4 
                 DnaJ (Hsp40) 
                 0.0037 
                 0.2405 
                 1.6 
               
               
                   
                   
                   
                 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily B, 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 
                   
                   
                   
               
               
                 210858_x_at 
                 U26455 
                 ATM 
                 ataxia 
                 0.0045 
                 0.0493 
                 1.6 
               
               
                   
                   
                   
                 telangiectasia 
                   
                   
                   
               
               
                   
                   
                   
                 mutated (includes 
                   
                   
                   
               
               
                   
                   
                   
                 complementation 
                   
                   
                   
               
               
                   
                   
                   
                 groups A, C and D) 
                   
                   
                   
               
               
                 218645_at 
                 NM_021994 
                 ZNF277P 
                 zinc finger protein 
                 0.0030 
                 0.1008 
                 1.6 
               
               
                   
                   
                   
                 277 pseudogene 
                   
                   
                   
               
               
                 218142_s_at 
                 NM_016302 
                 CRBN 
                 cereblon 
                 0.0012 
                 0.1954 
                 1.6 
               
               
                 206363_at 
                 NM_005360 
                 MAF 
                 v-maf 
                 0.0089 
                 0.5222 
                 1.6 
               
               
                   
                   
                   
                 musculoaponeurotic 
                   
                   
                   
               
               
                   
                   
                   
                 fibrosarcoma 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene homolog 
                   
                   
                   
               
               
                   
                   
                   
                 (avian) 
                   
                   
                   
               
               
                 220917_s_at 
                 NM_025132 
                 WDR19 
                 WD repeat domain 
                 0.0010 
                 0.2438 
                 1.6 
               
               
                   
                   
                   
                 19 
                   
                   
                   
               
               
                 213413_at 
                 BG434174 
                 STON1 
                 stonin 1 
                 0.0079 
                 0.7123 
                 1.6 
               
               
                 203227_s_at 
                 NM_005981 
                 TSPAN31 
                 tetraspanin 31 
                 0.0079 
                 0.3100 
                 1.6 
               
               
                 222273_at 
                 AI419423 
                 PAPOLG 
                 poly(A) 
                 0.0365 
                 0.6023 
                 1.6 
               
               
                   
                   
                   
                 polymerase gamma 
                   
                   
                   
               
               
                 202160_at 
                 NM_004380 
                 CREBBP 
                 CREB binding 
                 0.0026 
                 0.3771 
                 1.6 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 (Rubinstein-Taybi 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome) 
                   
                   
                   
               
               
                 202105_at 
                 NM_001551 
                 IGBP1 
                 immunoglobulin 
                 0.0004 
                 0.0261 
                 1.6 
               
               
                   
                   
                   
                 (CD79A) binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 215450_at 
                 W87901 
                 — 
                 — 
                 0.0185 
                 0.1143 
                 1.6 
               
               
                 217988_at 
                 NM_021178 
                 CCNB1IP1 
                 cyclin B1 
                 0.0005 
                 0.0571 
                 1.6 
               
               
                   
                   
                   
                 interacting protein 1 
                   
                   
                   
               
               
                 212956_at 
                 AI348094 
                 TBC1D9 
                 TBC1 domain 
                 0.0005 
                 0.0274 
                 1.6 
               
               
                   
                   
                   
                 family, member 9 
                   
                   
                   
               
               
                   
                   
                   
                 (with GRAM 
                   
                   
                   
               
               
                   
                   
                   
                 domain) 
                   
                   
                   
               
               
                 212448_at 
                 AB007899 
                 NEDD4L 
                 neural precursor 
                 0.0043 
                 0.4684 
                 1.6 
               
               
                   
                   
                   
                 cell expressed, 
                   
                   
                   
               
               
                   
                   
                   
                 developmentally 
                   
                   
                   
               
               
                   
                   
                   
                 down-regulated 4- 
                   
                   
                   
               
               
                   
                   
                   
                 like 
                   
                   
                   
               
               
                 203789_s_at 
                 NM_006379 
                 SEMA3C 
                 sema domain, 
                 0.0051 
                 0.3375 
                 1.6 
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 domain (Ig), short 
                   
                   
                   
               
               
                   
                   
                   
                 basic domain, 
                   
                   
                   
               
               
                   
                   
                   
                 secreted, 
                   
                   
                   
               
               
                   
                   
                   
                 (semaphorin) 3C 
                   
                   
                   
               
               
                 214683_s_at 
                 AI251890 
                 CLK1 
                 CDC-like kinase 1 
                 0.0358 
                 0.7292 
                 1.6 
               
               
                 201008_s_at 
                 AA812232 
                 TXNIP 
                 thioredoxin 
                 0.0060 
                 0.3503 
                 1.6 
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 209212_s_at 
                 AB030824 
                 KLF5 
                 Kruppel-like factor 
                 0.0074 
                 0.4147 
                 1.6 
               
               
                   
                   
                   
                 5 (intestinal) 
                   
                   
                   
               
               
                 215043_s_at 
                 X83301 
                 SMA3 /// 
                 SMA3 /// SMA5 
                 0.0240 
                 0.8101 
                 1.6 
               
               
                   
                   
                 SMA5 
                   
                   
                   
                   
               
               
                 218603_at 
                 NM_016217 
                 HECA 
                 headcase homolog 
                 0.0026 
                 0.3544 
                 1.6 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 219599_at 
                 NM_018507 
                 PRO1843 
                 hypothetical 
                 0.0213 
                 0.5078 
                 1.6 
               
               
                   
                   
                   
                 protein PRO1843 
                   
                   
                   
               
               
                 212616_at 
                 BF668950 
                 CHD9 
                 chromodomain 
                 0.0061 
                 0.6115 
                 1.6 
               
               
                   
                   
                   
                 helicase DNA 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 9 
                   
                   
                   
               
               
                 210111_s_at 
                 AF277175 
                 KIAA0265 
                 KIAA0265 protein 
                 0.0024 
                 0.5594 
                 1.6 
               
               
                 213258_at 
                 BF511231 
                 TFPI 
                 tissue factor 
                 0.0050 
                 0.2677 
                 1.6 
               
               
                   
                   
                   
                 pathway inhibitor 
                   
                   
                   
               
               
                   
                   
                   
                 (lipoprotein- 
                   
                   
                   
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 coagulation 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor) 
                   
                   
                   
               
               
                 217627_at 
                 BE515346 
                 ZNF573 
                 zinc finger protein 
                 0.0188 
                 0.3191 
                 1.6 
               
               
                   
                   
                   
                 573 
                   
                   
                   
               
               
                 213032_at 
                 AI186739 
                 NFIB 
                 nuclear factor I/B 
                 0.0041 
                 0.0563 
                 1.6 
               
               
                 215071_s_at 
                 AL353759 
                 HIST1H2AC 
                 histone cluster 1, 
                 0.0021 
                 0.1437 
                 1.6 
               
               
                   
                   
                   
                 H2ac 
                   
                   
                   
               
               
                 206059_at 
                 NM_003430 
                 ZNF91 
                 zinc finger protein 
                 0.0109 
                 0.0953 
                 1.6 
               
               
                   
                   
                   
                 91 
                   
                   
                   
               
               
                 218168_s_at 
                 NM_020247 
                 CABC1 
                 chaperone, ABC1 
                 0.0046 
                 0.3869 
                 1.6 
               
               
                   
                   
                   
                 activity of bc1 
                   
                   
                   
               
               
                   
                   
                   
                 complex homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. pombe ) 
                   
                   
                   
               
               
                 201465_s_at 
                 BC002646 
                 JUN 
                 jun oncogene 
                 0.0055 
                 0.0800 
                 1.6 
               
               
                 218643_s_at 
                 NM_014171 
                 CRIPT 
                 cysteine-rich PDZ- 
                 0.0078 
                 0.7762 
                 1.6 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 213655_at 
                 AA502643 
                 PAFAH1B1 
                 Platelet-activating 
                 0.0017 
                 0.0157 
                 1.6 
               
               
                   
                   
                   
                 factor 
                   
                   
                   
               
               
                   
                   
                   
                 acetylhydrolase, 
                   
                   
                   
               
               
                   
                   
                   
                 isoform Ib, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 45 kDa 
                   
                   
                   
               
               
                 206565_x_at 
                 NM_006780 
                 SMA3 
                 SMA3 
                 0.0055 
                 0.8548 
                 1.6 
               
               
                 203298_s_at 
                 NM_004973 
                 JARID2 
                 jumonji, AT rich 
                 0.0007 
                 0.0705 
                 1.6 
               
               
                   
                   
                   
                 interactive domain 2 
                   
                   
                   
               
               
                 216623_x_at 
                 AK025084 
                 TNRC9 
                 trinucleotide repeat 
                 0.0255 
                 0.7718 
                 1.6 
               
               
                   
                   
                   
                 containing 9 
                   
                   
                   
               
               
                 204485_s_at 
                 NM_005486 
                 TOM1L1 
                 target of myb1-like 
                 0.0016 
                 0.3551 
                 1.6 
               
               
                   
                   
                   
                 1 (chicken) 
                   
                   
                   
               
               
                 205431_s_at 
                 NM_021073 
                 BMP5 
                 bone 
                 0.0075 
                 0.3673 
                 1.6 
               
               
                   
                   
                   
                 morphogenetic 
                   
                   
                   
               
               
                   
                   
                   
                 protein 5 
                   
                   
                   
               
               
                 205054_at 
                 NM_004543 
                 NEB 
                 nebulin 
                 0.0015 
                 0.2275 
                 1.6 
               
               
                 209750_at 
                 N32859 
                 NR1D2 
                 nuclear receptor 
                 0.0270 
                 0.0803 
                 1.6 
               
               
                   
                   
                   
                 subfamily 1, group 
                   
                   
                   
               
               
                   
                   
                   
                 D, member 2 
                   
                   
                   
               
               
                 208131_s_at 
                 NM_000961 
                 PTGIS 
                 prostaglandin I2 
                 0.0025 
                 0.0783 
                 1.6 
               
               
                   
                   
                   
                 (prostacyclin) 
                   
                   
                   
               
               
                   
                   
                   
                 synthase /// 
                   
                   
                   
               
               
                   
                   
                   
                 prostaglandin I2 
                   
                   
                   
               
               
                   
                   
                   
                 (prostacyclin) 
                   
                   
                   
               
               
                   
                   
                   
                 synthase 
                   
                   
                   
               
               
                 219679_s_at 
                 NM_018604 
                 WAC 
                 WW domain 
                 0.0129 
                 0.1806 
                 1.6 
               
               
                   
                   
                   
                 containing adaptor 
                   
                   
                   
               
               
                   
                   
                   
                 with coiled-coil 
                   
                   
                   
               
               
                 221763_at 
                 AI694023 
                 JMJD1C 
                 jumonji domain 
                 0.0007 
                 0.0389 
                 1.6 
               
               
                   
                   
                   
                 containing 1C 
                   
                   
                   
               
               
                 203420_at 
                 NM_016255 
                 FAM8A1 
                 family with 
                 0.0043 
                 0.1789 
                 1.6 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 8, member A1 
                   
                   
                   
               
               
                 210102_at 
                 BC001234 
                 LOH11CR2A 
                 loss of 
                 0.0183 
                 0.4585 
                 1.5 
               
               
                   
                   
                   
                 heterozygosity, 11, 
                   
                   
                   
               
               
                   
                   
                   
                 chromosomal 
                   
                   
                   
               
               
                   
                   
                   
                 region 2, gene A 
                   
                   
                   
               
               
                 212936_at 
                 AI927701 
                 C5orf21 
                 chromosome 5 
                 0.0020 
                 0.1531 
                 1.5 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 21 
                   
                   
                   
               
               
                 204726_at 
                 NM_001257 
                 CDH13 
                 cadherin 13, H- 
                 0.0388 
                 0.7671 
                 1.5 
               
               
                   
                   
                   
                 cadherin (heart) 
                   
                   
                   
               
               
                 202832_at 
                 NM_014635 
                 GCC2 
                 GRIP and coiled- 
                 0.0047 
                 0.2332 
                 1.5 
               
               
                   
                   
                   
                 coil domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 2 
                   
                   
                   
               
               
                 203510_at 
                 BG170541 
                 MET 
                 met proto- 
                 0.0049 
                 0.3651 
                 1.5 
               
               
                   
                   
                   
                 oncogene 
                   
                   
                   
               
               
                   
                   
                   
                 (hepatocyte growth 
                   
                   
                   
               
               
                   
                   
                   
                 factor receptor) 
                   
                   
                   
               
               
                 207186_s_at 
                 NM_004459 
                 BPTF 
                 bromodomain PHD 
                 0.0135 
                 0.2421 
                 1.5 
               
               
                   
                   
                   
                 finger transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factor 
                   
                   
                   
               
               
                 212593_s_at 
                 N92498 
                 PDCD4 
                 programmed cell 
                 0.0059 
                 0.7650 
                 1.5 
               
               
                   
                   
                   
                 death 4 (neoplastic 
                   
                   
                   
               
               
                   
                   
                   
                 transformation 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor) 
                   
                   
                   
               
               
                 203491_s_at 
                 AI123527 
                 CEP57 
                 centrosomal 
                 0.0149 
                 0.1552 
                 1.5 
               
               
                   
                   
                   
                 protein 57 kDa 
                   
                   
                   
               
               
                 217100_s_at 
                 AK026451 
                 UBXD7 
                 UBX domain 
                 0.0069 
                 0.2624 
                 1.5 
               
               
                   
                   
                   
                 containing 7 
                   
                   
                   
               
               
                 210346_s_at 
                 AF212224 
                 CLK4 
                 CDC-like kinase 4 
                 0.0007 
                 0.0252 
                 1.5 
               
               
                 218277_s_at 
                 NM_024612 
                 DHX40 
                 DEAH (Asp-Glu- 
                 0.0049 
                 0.6421 
                 1.5 
               
               
                   
                   
                   
                 Ala-His) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 40 
                   
                   
                   
               
               
                 212764_at 
                 AI806174 
                 — 
                 — 
                 0.0031 
                 0.1646 
                 1.5 
               
               
                 207170_s_at 
                 NM_015416 
                 LETMD1 
                 LETM1 domain 
                 0.0020 
                 0.4216 
                 1.5 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 213939_s_at 
                 AI871641 
                 RUFY3 
                 RUN and FYVE 
                 0.0143 
                 0.7780 
                 1.5 
               
               
                   
                   
                   
                 domain containing 3 
                   
                   
                   
               
               
                 210962_s_at 
                 AB019691 
                 AKAP9 
                 A kinase (PRKA) 
                 0.0062 
                 0.7228 
                 1.5 
               
               
                   
                   
                   
                 anchor protein 
                   
                   
                   
               
               
                   
                   
                   
                 (yotiao) 9 
                   
                   
                   
               
               
                 201637_s_at 
                 NM_005087 
                 FXR1 
                 fragile X mental 
                 0.0100 
                 0.6502 
                 1.5 
               
               
                   
                   
                   
                 retardation, 
                   
                   
                   
               
               
                   
                   
                   
                 autosomal 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                 200965_s_at 
                 NM_006720 
                 ABLIM1 
                 actin binding LIM 
                 0.0017 
                 0.0274 
                 1.5 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 203139_at 
                 NM_004938 
                 DAPK1 
                 death-associated 
                 0.0051 
                 0.8963 
                 1.5 
               
               
                   
                   
                   
                 protein kinase 1 
                   
                   
                   
               
               
                 201737_s_at 
                 NM_005885 
                 6-Mar 
                 membrane- 
                 0.0112 
                 0.5449 
                 1.5 
               
               
                   
                   
                   
                 associated ring 
                   
                   
                   
               
               
                   
                   
                   
                 finger (C3HC4) 6 
                   
                   
                   
               
               
                 221190_s_at 
                 NM_013326 
                 C18orf8 
                 chromosome 18 
                 0.0095 
                 0.4956 
                 1.5 
               
               
                   
                   
                   
                 open reading frame 8 
                   
                   
                   
               
               
                 218330_s_at 
                 NM_018162 
                 NAV2 
                 neuron navigator 2 
                 0.0163 
                 0.7871 
                 1.5 
               
               
                 217783_s_at 
                 NM_016061 
                 YPEL5 
                 yippee-like 5 
                 0.0033 
                 0.1201 
                 1.5 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 205824_at 
                 NM_001541 
                 HSPB2 
                 heat shock 27 kDa 
                 0.0139 
                 0.6070 
                 1.5 
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 211675_s_at 
                 AF054589 
                 MDFIC 
                 MyoD family 
                 0.0029 
                 0.1408 
                 1.5 
               
               
                   
                   
                   
                 inhibitor domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing /// 
                   
                   
                   
               
               
                   
                   
                   
                 MyoD family 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                 218625_at 
                 NM_016588 
                 NRN1 
                 neuritin 1 
                 0.0465 
                 0.5695 
                 1.5 
               
               
                 214016_s_at 
                 AL558875 
                 SFPQ 
                 splicing factor 
                 0.0146 
                 0.5232 
                 1.5 
               
               
                   
                   
                   
                 proline/glutamine- 
                   
                   
                   
               
               
                   
                   
                   
                 rich 
                   
                   
                   
               
               
                   
                   
                   
                 (polypyrimidine 
                   
                   
                   
               
               
                   
                   
                   
                 tract binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein associated) 
                   
                   
                   
               
               
                 212634_at 
                 AW298092 
                 KIAA0776 
                 KIAA0776 
                 0.0198 
                 0.0537 
                 1.5 
               
               
                 213002_at 
                 AA770596 
                 MARCKS 
                 Myristoylated 
                 0.0105 
                 0.1001 
                 1.5 
               
               
                   
                   
                   
                 alanine-rich protein 
                   
                   
                   
               
               
                   
                   
                   
                 kinase C substrate 
                   
                   
                   
               
               
                 212654_at 
                 AL566786 
                 TPM2 /// 
                 tropomyosin 2 
                 0.0166 
                 0.6932 
                 1.5 
               
               
                   
                   
                 PPIL5 
                 (beta) /// 
                   
                   
                   
               
               
                   
                   
                   
                 peptidylprolyl 
                   
                   
                   
               
               
                   
                   
                   
                 isomerase 
                   
                   
                   
               
               
                   
                   
                   
                 (cyclophilin)-like 5 
                   
                   
                   
               
               
                 200962_at 
                 AI348010 
                 RPL31 /// 
                 ribosomal protein 
                 0.0047 
                 0.3069 
                 1.5 
               
               
                   
                   
                 LOC285260 
                 L31 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 RPL31P4 
                 L31 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein L31 
                   
                   
                   
               
               
                   
                   
                 RPL31P10 
                 pseudogene 4 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC641790 
                 L31 pseudogene 10 
                   
                   
                   
               
               
                   
                   
                 /// 
                 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC646841 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 L31 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC648737 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 L31 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC653773 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 L31 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC727792 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 L31 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC729646 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 L31 /// 
                   
                   
                   
               
               
                   
                   
                 LOC732015 
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC729646 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L31 
                   
                   
                   
               
               
                 217591_at 
                 BF725121 
                 SKIL 
                 SKI-like oncogene 
                 0.0284 
                 0.1213 
                 1.5 
               
               
                 211161_s_at 
                 AF130082 
                 COL3A1 
                 collagen, type III, 
                 0.0016 
                 0.4548 
                 1.5 
               
               
                   
                   
                   
                 alpha 1 (Ehlers- 
                   
                   
                   
               
               
                   
                   
                   
                 Danlos syndrome 
                   
                   
                   
               
               
                   
                   
                   
                 type IV, autosomal 
                   
                   
                   
               
               
                   
                   
                   
                 dominant) 
                   
                   
                   
               
               
                 208796_s_at 
                 BC000196 
                 CCNG1 
                 cyclin G1 
                 0.0018 
                 0.2131 
                 1.5 
               
               
                 214042_s_at 
                 AW071997 
                 RPL22 
                 ribosomal protein 
                 0.0007 
                 0.0592 
                 1.5 
               
               
                   
                   
                   
                 L22 
                   
                   
                   
               
               
                 220755_s_at 
                 NM_016947 
                 C6orf48 
                 chromosome 6 
                 0.0005 
                 0.1746 
                 1.5 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 48 
                   
                   
                   
               
               
                 212665_at 
                 AL556438 
                 TIPARP 
                 TCDD-inducible 
                 0.0025 
                 0.2295 
                 1.5 
               
               
                   
                   
                   
                 poly(ADP-ribose) 
                   
                   
                   
               
               
                   
                   
                   
                 polymerase 
                   
                   
                   
               
               
                 212773_s_at 
                 BG165094 
                 TOMM20 
                 translocase of outer 
                 0.0188 
                 0.1173 
                 1.5 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 membrane 20 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 212455_at 
                 N36997 
                 YTHDC1 
                 YTH domain 
                 0.0010 
                 0.0732 
                 1.5 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 201285_at 
                 NM_013446 
                 MKRN1 
                 makorin, ring 
                 0.0045 
                 0.9558 
                 1.5 
               
               
                   
                   
                   
                 finger protein, 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 makorin, ring 
                   
                   
                   
               
               
                   
                   
                   
                 finger protein, 1 
                   
                   
                   
               
               
                 203140_at 
                 NM_001706 
                 BCL6 
                 B-cell 
                 0.0135 
                 0.6753 
                 1.5 
               
               
                   
                   
                   
                 CLL/lymphoma 6 
                   
                   
                   
               
               
                   
                   
                   
                 (zinc finger protein 
                   
                   
                   
               
               
                   
                   
                   
                 51) /// B-cell 
                   
                   
                   
               
               
                   
                   
                   
                 CLL/lymphoma 6 
                   
                   
                   
               
               
                   
                   
                   
                 (zinc finger protein 
                   
                   
                   
               
               
                   
                   
                   
                 51) 
                   
                   
                   
               
               
                 212451_at 
                 N52532 
                 KIAA0256 
                 KIAA0256 gene 
                 0.0190 
                 0.0968 
                 1.5 
               
               
                   
                   
                   
                 product 
                   
                   
                   
               
               
                 203002_at 
                 NM_016201 
                 AMOTL2 
                 angiomotin like 2 
                 0.0311 
                 0.1937 
                 1.5 
               
               
                 208886_at 
                 BC000145 
                 H1F0 
                 H1 histone family, 
                 0.0008 
                 0.2034 
                 1.5 
               
               
                   
                   
                   
                 member 0 
                   
                   
                   
               
               
                 204094_s_at 
                 NM_014779 
                 TSC22D2 
                 TSC22 domain 
                 0.0034 
                 0.5023 
                 1.5 
               
               
                   
                   
                   
                 family, member 2 
                   
                   
                   
               
               
                 204822_at 
                 NM_003318 
                 TTK 
                 TTK protein kinase 
                 0.0086 
                 0.1596 
                 1.5 
               
               
                 213241_at 
                 AF035307 
                 PLXNC1 
                 plexin C1 
                 0.0283 
                 0.9168 
                 1.5 
               
               
                 209286_at 
                 AI754416 
                 CDC42EP3 
                 CDC42 effector 
                 0.0050 
                 0.2353 
                 1.5 
               
               
                   
                   
                   
                 protein (Rho 
                   
                   
                   
               
               
                   
                   
                   
                 GTPase binding) 3 
                   
                   
                   
               
               
                 206572_x_at 
                 NM_003429 
                 ZNF85 
                 zinc finger protein 
                 0.0206 
                 0.6963 
                 1.5 
               
               
                   
                   
                   
                 85 
                   
                   
                   
               
               
                 222288_at 
                 AI004009 
                 — 
                 Transcribed locus, 
                 0.0045 
                 0.2761 
                 1.5 
               
               
                   
                   
                   
                 weakly similar to 
                   
                   
                   
               
               
                   
                   
                   
                 NP_001013658.1 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC387873 
                   
                   
                   
               
               
                   
                   
                   
                 [ Homo sapiens ] 
                   
                   
                   
               
               
                 206829_x_at 
                 NM_025189 
                 ZNF430 
                 zinc finger protein 
                 0.0074 
                 0.4605 
                 1.5 
               
               
                   
                   
                   
                 430 
                   
                   
                   
               
               
                 214280_x_at 
                 X79536 
                 HNRPA1 
                 heterogeneous 
                 0.0029 
                 0.1967 
                 1.5 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 A1 
                   
                   
                   
               
               
                 217936_at 
                 AW044631 
                 ARHGAP5 
                 Rho GTPase 
                 0.0214 
                 0.5528 
                 1.5 
               
               
                   
                   
                   
                 activating protein 5 
                   
                   
                   
               
               
                 212463_at 
                 BE379006 
                 CD59 
                 CD59 molecule, 
                 0.0012 
                 0.1864 
                 1.5 
               
               
                   
                   
                   
                 complement 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory protein 
                   
                   
                   
               
               
                 208835_s_at 
                 AW089673 
                 CROP 
                 cisplatin 
                 0.0311 
                 0.1778 
                 1.5 
               
               
                   
                   
                   
                 resistance- 
                   
                   
                   
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 overexpressed 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 203640_at 
                 BE328496 
                 MBNL2 
                 muscleblind-like 2 
                 0.0030 
                 0.0670 
                 1.4 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 218316_at 
                 NM_012460 
                 TIMM9 
                 translocase of inner 
                 0.0042 
                 0.1350 
                 1.4 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 membrane 9 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 204920_at 
                 AF154830 
                 CPS1 
                 carbamoyl- 
                 0.0095 
                 0.7685 
                 1.4 
               
               
                   
                   
                   
                 phosphate 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 1, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 205022_s_at 
                 NM_005197 
                 CHES1 
                 checkpoint 
                 0.0085 
                 0.2652 
                 1.4 
               
               
                   
                   
                   
                 suppressor 1 
                   
                   
                   
               
               
                 205443_at 
                 NM_003082 
                 SNAPC1 
                 small nuclear RNA 
                 0.0038 
                 0.0942 
                 1.4 
               
               
                   
                   
                   
                 activating complex, 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 1, 
                   
                   
                   
               
               
                   
                   
                   
                 43 kDa 
                   
                   
                   
               
               
                 204215_at 
                 NM_024315 
                 C7orf23 
                 chromosome 7 
                 0.0100 
                 0.3811 
                 1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 23 
                   
                   
                   
               
               
                 202023_at 
                 NM_004428 
                 EFNA1 
                 ephrin-A1 
                 0.0135 
                 0.5642 
                 1.4 
               
               
                 203538_at 
                 NM_001745 
                 CAMLG 
                 calcium 
                 0.0082 
                 0.0804 
                 1.4 
               
               
                   
                   
                 /// 
                 modulating ligand 
                   
                   
                   
               
               
                   
                   
                 FAM39DP 
                 /// family with 
                   
                   
                   
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 39, member D 
                   
                   
                   
               
               
                   
                   
                   
                 pseudogene 
                   
                   
                   
               
               
                 202976_s_at 
                 NM_014899 
                 RHOBTB3 
                 Rho-related BTB 
                 0.0039 
                 0.1116 
                 1.4 
               
               
                   
                   
                   
                 domain containing 3 
                   
                   
                   
               
               
                 205811_at 
                 NM_007215 
                 POLG2 
                 polymerase (DNA 
                 0.0160 
                 0.7714 
                 1.4 
               
               
                   
                   
                   
                 directed), gamma 
                   
                   
                   
               
               
                   
                   
                   
                 2, accessory 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                 218253_s_at 
                 NM_006893 
                 LGTN 
                 ligatin 
                 0.0064 
                 0.2044 
                 1.4 
               
               
                 210312_s_at 
                 BC002640 
                 IFT20 
                 intraflagellar 
                 0.0087 
                 0.2350 
                 1.4 
               
               
                   
                   
                   
                 transport 20 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Chlamydomonas ) 
                   
                   
                   
               
               
                 217990_at 
                 NM_016576 
                 GMPR2 
                 guanosine 
                 0.0035 
                 0.2297 
                 1.4 
               
               
                   
                   
                   
                 monophosphate 
                   
                   
                   
               
               
                   
                   
                   
                 reductase 2 
                   
                   
                   
               
               
                 204633_s_at 
                 AF074393 
                 RPS6KA5 
                 ribosomal protein 
                 0.0232 
                 0.5765 
                 1.4 
               
               
                   
                   
                   
                 S6 kinase, 90 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 5 
                   
                   
                   
               
               
                 221499_s_at 
                 AK026970 
                 STX16 
                 syntaxin 16 
                 0.0114 
                 0.1455 
                 1.4 
               
               
                 205954_at 
                 NM_006917 
                 RXRG 
                 retinoid X receptor, 
                 0.0050 
                 0.0389 
                 1.4 
               
               
                   
                   
                   
                 gamma 
                   
                   
                   
               
               
                 202956_at 
                 NM_006421 
                 ARFGEF1 
                 ADP-ribosylation 
                 0.0270 
                 0.6102 
                 1.4 
               
               
                   
                   
                   
                 factor guanine 
                   
                   
                   
               
               
                   
                   
                   
                 nucleotide- 
                   
                   
                   
               
               
                   
                   
                   
                 exchange factor 
                   
                   
                   
               
               
                   
                   
                   
                 1(brefeldin A- 
                   
                   
                   
               
               
                   
                   
                   
                 inhibited) 
                   
                   
                   
               
               
                 213844_at 
                 NM_019102 
                 HOXA5 
                 homeobox A5 
                 0.0046 
                 0.1113 
                 1.4 
               
               
                 220924_s_at 
                 NM_018976 
                 SLC38A2 
                 solute carrier 
                 0.0060 
                 0.6814 
                 1.4 
               
               
                   
                   
                   
                 family 38, member 2 
                   
                   
                   
               
               
                 209656_s_at 
                 AL136550 
                 TMEM47 
                 transmembrane 
                 0.0015 
                 0.3325 
                 1.4 
               
               
                   
                   
                   
                 protein 47 
                   
                   
                   
               
               
                 208204_s_at 
                 NM_001234 
                 CAV3 
                 caveolin 3 
                 0.0078 
                 0.9326 
                 1.4 
               
               
                 205872_x_at 
                 NM_022359 
                 PDE4DIP 
                 phosphodiesterase 
                 0.0299 
                 0.0719 
                 1.4 
               
               
                   
                   
                   
                 4D interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 (myomegalin) 
                   
                   
                   
               
               
                 213605_s_at 
                 AL049987 
                 LOC728411 
                 Similar to Beta- 
                 0.0399 
                 0.3946 
                 1.4 
               
               
                   
                   
                   
                 glucuronidase 
                   
                   
                   
               
               
                   
                   
                   
                 precursor 
                   
                   
                   
               
               
                 201417_at 
                 AL136179 
                 SOX4 
                 SRY (sex 
                 0.0121 
                 0.4154 
                 1.4 
               
               
                   
                   
                   
                 determining region 
                   
                   
                   
               
               
                   
                   
                   
                 Y)-box 4 
                   
                   
                   
               
               
                 200912_s_at 
                 NM_001967 
                 EIF4A2 
                 eukaryotic 
                 0.0005 
                 0.0721 
                 1.4 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 
                   
                   
                   
               
               
                   
                   
                   
                 4A, isoform 2 
                   
                   
                   
               
               
                 217987_at 
                 NM_019048 
                 ASNSD1 
                 asparagine 
                 0.0226 
                 0.2254 
                 1.4 
               
               
                   
                   
                   
                 synthetase domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 212689_s_at 
                 AA524505 
                 JMJD1A 
                 jumonji domain 
                 0.0012 
                 0.1485 
                 1.4 
               
               
                   
                   
                   
                 containing 1A 
                   
                   
                   
               
               
                 218268_at 
                 NM_022771 
                 TBC1D15 
                 TBC1 domain 
                 0.0245 
                 0.3320 
                 1.4 
               
               
                   
                   
                   
                 family, member 15 
                   
                   
                   
               
               
                 201616_s_at 
                 AL577531 
                 CALD1 
                 caldesmon 1 
                 0.0442 
                 0.2187 
                 1.4 
               
               
                 212675_s_at 
                 AB011154 
                 — 
                 — 
                 0.0149 
                 0.7153 
                 1.4 
               
               
                 218397_at 
                 NM_018062 
                 FANCL 
                 Fanconi anemia, 
                 0.0064 
                 0.1684 
                 1.4 
               
               
                   
                   
                   
                 complementation 
                   
                   
                   
               
               
                   
                   
                   
                 group L 
                   
                   
                   
               
               
                 209181_s_at 
                 U49245 
                 RABGGTB 
                 Rab 
                 0.0031 
                 0.1108 
                 1.4 
               
               
                   
                   
                   
                 geranylgeranyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 beta 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                 215983_s_at 
                 D83768 
                 UBXD6 
                 UBX domain 
                 0.0214 
                 0.2921 
                 1.4 
               
               
                   
                   
                   
                 containing 6 
                   
                   
                   
               
               
                 209781_s_at 
                 AF069681 
                 KHDRBS3 
                 KH domain 
                 0.0013 
                 0.3269 
                 1.4 
               
               
                   
                   
                   
                 containing, RNA 
                   
                   
                   
               
               
                   
                   
                   
                 binding, signal 
                   
                   
                   
               
               
                   
                   
                   
                 transduction 
                   
                   
                   
               
               
                   
                   
                   
                 associated 3 
                   
                   
                   
               
               
                 201200_at 
                 NM_003851 
                 CREG1 
                 cellular repressor 
                 0.0121 
                 0.2634 
                 1.4 
               
               
                   
                   
                   
                 of E1A-stimulated 
                   
                   
                   
               
               
                   
                   
                   
                 genes 1 
                   
                   
                   
               
               
                 213619_at 
                 AV753392 
                 HNRPH1 
                 Heterogeneous 
                 0.0052 
                 0.0417 
                 1.4 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 H1 (H) 
                   
                   
                   
               
               
                 201549_x_at 
                 NM_006618 
                 JARID1B 
                 jumonji, AT rich 
                 0.0176 
                 0.5037 
                 1.4 
               
               
                   
                   
                   
                 interactive domain 
                   
                   
                   
               
               
                   
                   
                   
                 1B 
                   
                   
                   
               
               
                 200899_s_at 
                 NM_012215 
                 MGEA5 
                 meningioma 
                 0.0261 
                 0.5721 
                 1.4 
               
               
                   
                   
                   
                 expressed antigen 5 
                   
                   
                   
               
               
                   
                   
                   
                 (hyaluronidase) 
                   
                   
                   
               
               
                 218718_at 
                 NM_016205 
                 PDGFC 
                 platelet derived 
                 0.0007 
                 0.0280 
                 1.4 
               
               
                   
                   
                   
                 growth factor C 
                   
                   
                   
               
               
                 201289_at 
                 NM_001554 
                 CYR61 
                 cysteine-rich, 
                 0.0154 
                 0.4485 
                 1.4 
               
               
                   
                   
                   
                 angiogenic inducer, 
                   
                   
                   
               
               
                   
                   
                   
                 61 
                   
                   
                   
               
               
                 202118_s_at 
                 AA541758 
                 CPNE3 
                 copine III 
                 0.0079 
                 0.0589 
                 1.4 
               
               
                 200620_at 
                 NM_004872 
                 TMEM59 
                 transmembrane 
                 0.0007 
                 0.2260 
                 1.4 
               
               
                   
                   
                   
                 protein 59 
                   
                   
                   
               
               
                 213645_at 
                 AF305057 
                 ENOSF1 
                 enolase 
                 0.0273 
                 0.6899 
                 1.4 
               
               
                   
                   
                   
                 superfamily 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 202906_s_at 
                 AF049895 
                 NBN 
                 nibrin 
                 0.0383 
                 0.0964 
                 1.4 
               
               
                 209205_s_at 
                 BC003600 
                 LMO4 
                 LIM domain only 4 
                 0.0029 
                 0.1916 
                 1.4 
               
               
                 205361_s_at 
                 AI718295 
                 PFDN4 
                 prefoldin subunit 4 
                 0.0037 
                 0.0482 
                 1.4 
               
               
                 208697_s_at 
                 BC000734 
                 EIF3S6 
                 eukaryotic 
                 0.0012 
                 0.0582 
                 1.4 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 6 48 kDa 
                   
                   
                   
               
               
                 203881_s_at 
                 NM_004010 
                 DMD 
                 dystrophin 
                 0.0152 
                 0.0504 
                 1.4 
               
               
                   
                   
                   
                 (muscular 
                   
                   
                   
               
               
                   
                   
                   
                 dystrophy, 
                   
                   
                   
               
               
                   
                   
                   
                 Duchenne and 
                   
                   
                   
               
               
                   
                   
                   
                 Becker types) 
                   
                   
                   
               
               
                 202227_s_at 
                 NM_006696 
                 BRD8 
                 bromodomain 
                 0.0046 
                 0.0774 
                 1.4 
               
               
                   
                   
                   
                 containing 8 
                   
                   
                   
               
               
                 201166_s_at 
                 NM_014676 
                 PUM1 
                 pumilio homolog 1 
                 0.0007 
                 0.5211 
                 1.4 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 213967_at 
                 AI634532 
                 LOC138046 
                 hypothetical 
                 0.0337 
                 0.4178 
                 1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC138046 
                   
                   
                   
               
               
                 203117_s_at 
                 NM_014871 
                 USP52 
                 ubiquitin specific 
                 0.0177 
                 0.5403 
                 1.4 
               
               
                   
                   
                   
                 peptidase 52 
                   
                   
                   
               
               
                 212209_at 
                 AL133033 
                 THRAP2 
                 thyroid hormone 
                 0.0041 
                 0.6494 
                 1.4 
               
               
                   
                   
                   
                 receptor associated 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 204588_s_at 
                 NM_003982 
                 SLC7A7 
                 solute carrier 
                 0.0051 
                 0.1846 
                 1.4 
               
               
                   
                   
                   
                 family 7 (cationic 
                   
                   
                   
               
               
                   
                   
                   
                 amino acid 
                   
                   
                   
               
               
                   
                   
                   
                 transporter, y+ 
                   
                   
                   
               
               
                   
                   
                   
                 system), member 7 
                   
                   
                   
               
               
                 214451_at 
                 NM_003221 
                 TFAP2B 
                 transcription factor 
                 0.0190 
                 0.1948 
                 1.4 
               
               
                   
                   
                   
                 AP-2 beta 
                   
                   
                   
               
               
                   
                   
                   
                 (activating 
                   
                   
                   
               
               
                   
                   
                   
                 enhancer binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2 beta) 
                   
                   
                   
               
               
                 215096_s_at 
                 AU145746 
                 ESD 
                 esterase 
                 0.0032 
                 0.1013 
                 1.4 
               
               
                   
                   
                   
                 D/formylglutathione 
                   
                   
                   
               
               
                   
                   
                   
                 hydrolase 
                   
                   
                   
               
               
                 213224_s_at 
                 AK025724 
                 LOC92482 
                 hypothetical 
                 0.0079 
                 0.0654 
                 1.4 
               
               
                   
                   
                   
                 protein LOC92482 
                   
                   
                   
               
               
                 201174_s_at 
                 NM_018975 
                 TERF2IP 
                 telomeric repeat 
                 0.0222 
                 0.3358 
                 1.4 
               
               
                   
                   
                   
                 binding factor 2, 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 201735_s_at 
                 NM_001829 
                 CLCN3 
                 chloride channel 3 
                 0.0415 
                 0.3570 
                 1.4 
               
               
                 209130_at 
                 BC003686 
                 SNAP23 
                 synaptosomal- 
                 0.0124 
                 0.1309 
                 1.4 
               
               
                   
                   
                   
                 associated protein, 
                   
                   
                   
               
               
                   
                   
                   
                 23 kDa 
                   
                   
                   
               
               
                 207992_s_at 
                 NM_000480 
                 AMPD3 
                 adenosine 
                 0.0015 
                 0.0645 
                 1.4 
               
               
                   
                   
                   
                 monophosphate 
                   
                   
                   
               
               
                   
                   
                   
                 deaminase 
                   
                   
                   
               
               
                   
                   
                   
                 (isoform E) 
                   
                   
                   
               
               
                 200091_s_at 
                 AA888388 
                 RPS25 
                 ribosomal protein 
                 0.0010 
                 0.0877 
                 1.4 
               
               
                   
                   
                   
                 S25 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S25 
                   
                   
                   
               
               
                 221471_at 
                 AW173623 
                 SERINC3 
                 serine incorporator 3 
                 0.0041 
                 0.1925 
                 1.4 
               
               
                 206132_at 
                 NM_002387 
                 MCC 
                 mutated in 
                 0.0154 
                 0.2417 
                 1.4 
               
               
                   
                   
                   
                 colorectal cancers 
                   
                   
                   
               
               
                 207598_x_at 
                 NM_005431 
                 XRCC2 
                 X-ray repair 
                 0.0088 
                 0.0663 
                 1.4 
               
               
                   
                   
                   
                 complementing 
                   
                   
                   
               
               
                   
                   
                   
                 defective repair in 
                   
                   
                   
               
               
                   
                   
                   
                 Chinese hamster 
                   
                   
                   
               
               
                   
                   
                   
                 cells 2 
                   
                   
                   
               
               
                 212530_at 
                 AL080111 
                 NEK7 
                 NIMA (never in 
                 0.0110 
                 0.9827 
                 1.4 
               
               
                   
                   
                   
                 mitosis gene a)- 
                   
                   
                   
               
               
                   
                   
                   
                 related kinase 7 
                   
                   
                   
               
               
                 218343_s_at 
                 NM_012086 
                 GTF3C3 
                 general 
                 0.0404 
                 0.7847 
                 1.4 
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIIC, polypeptide 3, 
                   
                   
                   
               
               
                   
                   
                   
                 102 kDa 
                   
                   
                   
               
               
                 217731_s_at 
                 NM_021999 
                 ITM2B 
                 integral membrane 
                 0.0189 
                 0.3784 
                 1.4 
               
               
                   
                   
                   
                 protein 2B 
                   
                   
                   
               
               
                 218181_s_at 
                 NM_017792 
                 MAP4K4 
                 mitogen-activated 
                 0.0042 
                 0.1923 
                 1.4 
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 4 
                   
                   
                   
               
               
                 209285_s_at 
                 N38985 
                 C3orf63 
                 chromosome 3 
                 0.0020 
                 0.1860 
                 1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 63 
                   
                   
                   
               
               
                 215245_x_at 
                 AA830884 
                 FMR1 
                 fragile X mental 
                 0.0393 
                 0.5658 
                 1.4 
               
               
                   
                   
                   
                 retardation 1 
                   
                   
                   
               
               
                 201922_at 
                 NM_014886 
                 TINP1 
                 TGF beta-inducible 
                 0.0004 
                 0.0197 
                 1.4 
               
               
                   
                   
                   
                 nuclear protein 1 
                   
                   
                   
               
               
                 214800_x_at 
                 R83000 
                 BTF3 
                 basic transcription 
                 0.0015 
                 0.0280 
                 1.4 
               
               
                   
                   
                   
                 factor 3 
                   
                   
                   
               
               
                 212498_at 
                 AF056433 
                 — 
                 Full-length cDNA 
                 0.0047 
                 0.7550 
                 1.4 
               
               
                   
                   
                   
                 clone 
                   
                   
                   
               
               
                   
                   
                   
                 CS0DM001YA04 
                   
                   
                   
               
               
                   
                   
                   
                 of Fetal liver of 
                   
                   
                   
               
               
                   
                   
                   
                 
                   Homo sapiens 
                 
                   
                   
                   
               
               
                   
                   
                   
                 (human) 
                   
                   
                   
               
               
                 209004_s_at 
                 AF142481 
                 FBXL5 
                 F-box and leucine- 
                 0.0030 
                 0.0800 
                 1.4 
               
               
                   
                   
                   
                 rich repeat protein 5 
                   
                   
                   
               
               
                 204568_at 
                 NM_014924 
                 KIAA0831 
                 KIAA0831 
                 0.0129 
                 0.9702 
                 1.4 
               
               
                 216060_s_at 
                 AK021890 
                 DAAM1 
                 dishevelled 
                 0.0055 
                 0.0785 
                 1.4 
               
               
                   
                   
                   
                 associated activator 
                   
                   
                   
               
               
                   
                   
                   
                 of morphogenesis 1 
                   
                   
                   
               
               
                 201877_s_at 
                 NM_002719 
                 PPP2R5C 
                 protein 
                 0.0049 
                 0.1367 
                 1.4 
               
               
                   
                   
                   
                 phosphatase 2, 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory subunit 
                   
                   
                   
               
               
                   
                   
                   
                 B (B56), gamma 
                   
                   
                   
               
               
                   
                   
                   
                 isoform 
                   
                   
                   
               
               
                 203155_at 
                 NM_012432 
                 SETDB1 
                 SET domain, 
                 0.0110 
                 0.2112 
                 1.4 
               
               
                   
                   
                   
                 bifurcated 1 
                   
                   
                   
               
               
                 213762_x_at 
                 AI452524 
                 RBMX 
                 RNA binding motif 
                 0.0029 
                 0.2264 
                 1.4 
               
               
                   
                   
                   
                 protein, X-linked 
                   
                   
                   
               
               
                 203638_s_at 
                 NM_022969 
                 FGFR2 
                 fibroblast growth 
                 0.0029 
                 0.1774 
                 1.4 
               
               
                   
                   
                   
                 factor receptor 2 
                   
                   
                   
               
               
                   
                   
                   
                 (bacteria-expressed 
                   
                   
                   
               
               
                   
                   
                   
                 kinase, 
                   
                   
                   
               
               
                   
                   
                   
                 keratinocyte 
                   
                   
                   
               
               
                   
                   
                   
                 growth factor 
                   
                   
                   
               
               
                   
                   
                   
                 receptor, 
                   
                   
                   
               
               
                   
                   
                   
                 craniofacial 
                   
                   
                   
               
               
                   
                   
                   
                 dysostosis 1, 
                   
                   
                   
               
               
                   
                   
                   
                 Crouzon syndrome, 
                   
                   
                   
               
               
                   
                   
                   
                 Pfeiffer syndrome, 
                   
                   
                   
               
               
                   
                   
                   
                 Jackson-Weiss 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome) 
                   
                   
                   
               
               
                 213186_at 
                 BG502305 
                 DZIP3 
                 zinc finger DAZ 
                 0.0125 
                 0.4348 
                 1.4 
               
               
                   
                   
                   
                 interacting protein 3 
                   
                   
                   
               
               
                 218491_s_at 
                 NM_014174 
                 THYN1 
                 thymocyte nuclear 
                 0.0107 
                 0.3964 
                 1.4 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 218508_at 
                 NM_018403 
                 DCP1A 
                 DCP1 decapping 
                 0.0066 
                 0.7693 
                 1.4 
               
               
                   
                   
                   
                 enzyme homolog A 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 204528_s_at 
                 NM_004537 
                 NAP1L1 
                 nucleosome 
                 0.0015 
                 0.0941 
                 1.4 
               
               
                   
                   
                   
                 assembly protein 1- 
                   
                   
                   
               
               
                   
                   
                   
                 like 1 
                   
                   
                   
               
               
                 218919_at 
                 NM_024699 
                 ZFAND1 
                 zinc finger, AN1- 
                 0.0024 
                 0.0684 
                 1.4 
               
               
                   
                   
                   
                 type domain 1 
                   
                   
                   
               
               
                 57715_at 
                 W72694 
                 FAM26B 
                 family with 
                 0.0080 
                 0.1016 
                 1.4 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 26, member B 
                   
                   
                   
               
               
                 217550_at 
                 AA576497 
                 ATF6 
                 Activating 
                 0.0217 
                 0.2505 
                 1.4 
               
               
                   
                   
                   
                 transcription factor 6 
                   
                   
                   
               
               
                 212943_at 
                 AB011100 
                 KIAA0528 
                 KIAA0528 
                 0.0051 
                 0.2420 
                 1.4 
               
               
                 219767_s_at 
                 NM_005111 
                 CRYZL1 
                 crystallin, zeta 
                 0.0048 
                 0.8085 
                 1.4 
               
               
                   
                   
                   
                 (quinone 
                   
                   
                   
               
               
                   
                   
                   
                 reductase)-like 1 
                   
                   
                   
               
               
                 209861_s_at 
                 U13261 
                 METAP2 
                 methionyl 
                 0.0166 
                 0.2431 
                 1.4 
               
               
                   
                   
                   
                 aminopeptidase 2 
                   
                   
                   
               
               
                 201779_s_at 
                 AF070558 
                 RNF13 
                 ring finger protein 
                 0.0009 
                 0.0227 
                 1.4 
               
               
                   
                   
                   
                 13 
                   
                   
                   
               
               
                 214749_s_at 
                 AK000818 
                 ARMCX6 
                 armadillo repeat 
                 0.0125 
                 0.1875 
                 1.4 
               
               
                   
                   
                   
                 containing, X- 
                   
                   
                   
               
               
                   
                   
                   
                 linked 6 
                   
                   
                   
               
               
                 217266_at 
                 Z97353 
                 RPL15 /// 
                 ribosomal protein 
                 0.0072 
                 0.5812 
                 1.4 
               
               
                   
                   
                 LOC402694 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC646672 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC653232 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC728002 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC728088 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC728576 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC730925 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC731527 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC731822 
                 L15 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L15 
                   
                   
                   
               
               
                 221954_at 
                 AA160474 
                 C20orf111 
                 Chromosome 20 
                 0.0035 
                 0.1674 
                 1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 111 
                   
                   
                   
               
               
                 212074_at 
                 BE972774 
                 UNC84A 
                 unc-84 homolog A 
                 0.0051 
                 0.2261 
                 1.4 
               
               
                   
                   
                   
                 ( C. elegans ) 
                   
                   
                   
               
               
                 204131_s_at 
                 N25732 
                 FOXO3A 
                 forkhead box O3A 
                 0.0007 
                 0.0981 
                 1.4 
               
               
                 222182_s_at 
                 BG105204 
                 CNOT2 
                 CCR4-NOT 
                 0.0043 
                 0.1023 
                 1.4 
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 2 
                   
                   
                   
               
               
                 205935_at 
                 NM_001451 
                 FOXF1 
                 forkhead box F1 
                 0.0102 
                 0.5190 
                 1.4 
               
               
                 212812_at 
                 AI700633 
                 SERINC5 
                 Serine incorporator 5 
                 0.0069 
                 0.3193 
                 1.4 
               
               
                 221580_s_at 
                 BC001972 
                 JOSD3 
                 Josephin domain 
                 0.0323 
                 0.4333 
                 1.4 
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 217862_at 
                 N24868 
                 PIAS1 
                 protein inhibitor of 
                 0.0247 
                 0.1807 
                 1.4 
               
               
                   
                   
                   
                 activated STAT, 1 
                   
                   
                   
               
               
                 201133_s_at 
                 AA142966 
                 PJA2 
                 praja 2, RING-H2 
                 0.0189 
                 0.0968 
                 1.4 
               
               
                   
                   
                   
                 motif containing 
                   
                   
                   
               
               
                 208771_s_at 
                 J02959 
                 LTA4H 
                 leukotriene A4 
                 0.0004 
                 0.0344 
                 1.4 
               
               
                   
                   
                   
                 hydrolase 
                   
                   
                   
               
               
                 200074_s_at 
                 U16738 
                 RPL14 /// 
                 ribosomal protein 
                 0.0025 
                 0.0963 
                 1.4 
               
               
                   
                   
                 RPL14L 
                 L14 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein L14 /// 
                   
                   
                   
               
               
                   
                   
                 LOC649821 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L14-like /// 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L14-like /// similar 
                   
                   
                   
               
               
                   
                   
                   
                 to 60S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L14 (CAG- 
                   
                   
                   
               
               
                   
                   
                   
                 ISL 7) /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 60S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L14 (CAG- 
                   
                   
                   
               
               
                   
                   
                   
                 ISL 7) 
                   
                   
                   
               
               
                 212629_s_at 
                 AI633689 
                 PKN2 
                 protein kinase N2 
                 0.0106 
                 0.0285 
                 1.4 
               
               
                 209786_at 
                 BC001282 
                 HMGN4 
                 high mobility 
                 0.0124 
                 0.1345 
                 1.4 
               
               
                   
                   
                   
                 group nucleosomal 
                   
                   
                   
               
               
                   
                   
                   
                 binding domain 4 
                   
                   
                   
               
               
                 201738_at 
                 NM_005875 
                 EIF1B 
                 eukaryotic 
                 0.0100 
                 0.1022 
                 1.4 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 1B 
                   
                   
                   
               
               
                 206114_at 
                 NM_004438 
                 EPHA4 
                 EPH receptor A4 
                 0.0198 
                 0.1139 
                 1.4 
               
               
                 218361_at 
                 NM_018178 
                 GOLPH3L 
                 golgi 
                 0.0087 
                 0.5276 
                 1.4 
               
               
                   
                   
                   
                 phosphoprotein 3- 
                   
                   
                   
               
               
                   
                   
                   
                 like 
                   
                   
                   
               
               
                 202467_s_at 
                 NM_004236 
                 COPS2 
                 COP9 constitutive 
                 0.0052 
                 0.0436 
                 1.4 
               
               
                   
                   
                   
                 photomorphogenic 
                   
                   
                   
               
               
                   
                   
                   
                 homolog subunit 2 
                   
                   
                   
               
               
                   
                   
                   
                 ( Arabidopsis ) 
                   
                   
                   
               
               
                 219658_at 
                 NM_024754 
                 PTCD2 
                 pentatricopeptide 
                 0.0065 
                 0.4391 
                 1.4 
               
               
                   
                   
                   
                 repeat domain 2 
                   
                   
                   
               
               
                 217971_at 
                 NM_021970 
                 MAP2K1IP1 
                 mitogen-activated 
                 0.0183 
                 0.3561 
                 1.4 
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 1 interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 212408_at 
                 AK023204 
                 TOR1AIP1 
                 torsin A interacting 
                 0.0299 
                 0.1539 
                 1.4 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 212795_at 
                 AL137753 
                 KIAA1033 
                 KIAA1033 
                 0.0500 
                 0.9390 
                 1.4 
               
               
                 218004_at 
                 NM_018045 
                 BSDC1 
                 BSD domain 
                 0.0161 
                 0.1788 
                 1.4 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 205052_at 
                 NM_001698 
                 AUH 
                 AU RNA binding 
                 0.0042 
                 0.1537 
                 1.4 
               
               
                   
                   
                   
                 protein/enoyl- 
                   
                   
                   
               
               
                   
                   
                   
                 Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 hydratase 
                   
                   
                   
               
               
                 203097_s_at 
                 NM_014247 
                 RAPGEF2 
                 Rap guanine 
                 0.0399 
                 0.3291 
                 1.4 
               
               
                   
                   
                   
                 nucleotide 
                   
                   
                   
               
               
                   
                   
                   
                 exchange factor 
                   
                   
                   
               
               
                   
                   
                   
                 (GEF) 2 
                   
                   
                   
               
               
                 219077_s_at 
                 NM_016373 
                 WWOX 
                 WW domain 
                 0.0069 
                 0.1782 
                 1.4 
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                   
                   
                   
                 oxidoreductase 
                   
                   
                   
               
               
                 201917_s_at 
                 AI694452 
                 SLC25A36 
                 solute carrier 
                 0.0420 
                 0.0719 
                 1.4 
               
               
                   
                   
                   
                 family 25, member 
                   
                   
                   
               
               
                   
                   
                   
                 36 
                   
                   
                   
               
               
                 203630_s_at 
                 NM_006348 
                 COG5 
                 component of 
                 0.0160 
                 0.5887 
                 1.4 
               
               
                   
                   
                   
                 oligomeric golgi 
                   
                   
                   
               
               
                   
                   
                   
                 complex 5 
                   
                   
                   
               
               
                 216348_at 
                 AL049693 
                 RPS17 /// 
                 ribosomal protein 
                 0.0045 
                 0.2251 
                 1.4 
               
               
                   
                   
                 LOC402057 
                 S17 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S17 
                   
                   
                   
               
               
                 212111_at 
                 AA628051 
                 STX12 
                 syntaxin 12 
                 0.0054 
                 0.2425 
                 1.4 
               
               
                 202214_s_at 
                 NM_003588 
                 CUL4B 
                 cullin 4B 
                 0.0074 
                 0.4189 
                 1.4 
               
               
                 217807_s_at 
                 NM_015710 
                 GLTSCR2 
                 glioma tumor 
                 0.0015 
                 0.0474 
                 1.4 
               
               
                   
                   
                   
                 suppressor 
                   
                   
                   
               
               
                   
                   
                   
                 candidate region 
                   
                   
                   
               
               
                   
                   
                   
                 gene 2 
                   
                   
                   
               
               
                 219138_at 
                 BC000606 
                 RPL14 
                 ribosomal protein 
                 0.0084 
                 0.2776 
                 1.4 
               
               
                   
                   
                   
                 L14 
                   
                   
                   
               
               
                 212358_at 
                 AL117468 
                 CLIPR-59 
                 CLIP-170-related 
                 0.0131 
                 0.3968 
                 1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 221476_s_at 
                 AF279903 
                 RPL15 
                 ribosomal protein 
                 0.0016 
                 0.0696 
                 1.4 
               
               
                   
                   
                   
                 L15 
                   
                   
                   
               
               
                 203781_at 
                 NM_004891 
                 MRPL33 
                 mitochondrial 
                 0.0126 
                 0.0635 
                 1.4 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L33 
                   
                   
                   
               
               
                 221582_at 
                 BC001193 
                 HIST3H2A 
                 histone cluster 3, 
                 0.0043 
                 0.3642 
                 1.4 
               
               
                   
                   
                   
                 H2a 
                   
                   
                   
               
               
                 208667_s_at 
                 U17714 
                 ST13 
                 suppression of 
                 0.0140 
                 0.0995 
                 1.4 
               
               
                   
                   
                   
                 tumorigenicity 13 
                   
                   
                   
               
               
                   
                   
                   
                 (colon carcinoma) 
                   
                   
                   
               
               
                   
                   
                   
                 (Hsp70 interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein) 
                   
                   
                   
               
               
                 201358_s_at 
                 NM_016451 
                 COPB1 
                 coatomer protein 
                 0.0100 
                 0.1582 
                 1.4 
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 beta 1 
                   
                   
                   
               
               
                 211938_at 
                 BF247371 
                 EIF4B 
                 eukaryotic 
                 0.0050 
                 0.1793 
                 1.4 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 4B 
                   
                   
                   
               
               
                 212044_s_at 
                 BE737027 
                 RPL27A 
                 Ribosomal protein 
                 0.0457 
                 0.5986 
                 1.4 
               
               
                   
                   
                   
                 L27a 
                   
                   
                   
               
               
                 215978_x_at 
                 AK021514 
                 LOC152719 
                 hypothetical 
                 0.0135 
                 0.1439 
                 1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC152719 
                   
                   
                   
               
               
                 203910_at 
                 NM_004815 
                 ARHGAP29 
                 Rho GTPase 
                 0.0201 
                 0.5119 
                 1.4 
               
               
                   
                   
                   
                 activating protein 
                   
                   
                   
               
               
                   
                   
                   
                 29 
                   
                   
                   
               
               
                 209682_at 
                 U26710 
                 CBLB 
                 Cas-Br-M (murine) 
                 0.0128 
                 0.0489 
                 1.3 
               
               
                   
                   
                   
                 ecotropic retroviral 
                   
                   
                   
               
               
                   
                   
                   
                 transforming 
                   
                   
                   
               
               
                   
                   
                   
                 sequence b 
                   
                   
                   
               
               
                 202644_s_at 
                 NM_006290 
                 TNFAIP3 
                 tumor necrosis 
                 0.0322 
                 0.0856 
                 1.3 
               
               
                   
                   
                   
                 factor, alpha- 
                   
                   
                   
               
               
                   
                   
                   
                 induced protein 3 
                   
                   
                   
               
               
                 212215_at 
                 AB007896 
                 PREPL 
                 prolyl 
                 0.0076 
                 0.5632 
                 1.3 
               
               
                   
                   
                   
                 endopeptidase-like 
                   
                   
                   
               
               
                 218428_s_at 
                 NM_016316 
                 REV1 
                 REV1 homolog ( S. cerevisiae ) 
                 0.0211 
                 0.1542 
                 1.3 
               
               
                 217954_s_at 
                 NM_015153 
                 PHF3 
                 PHD finger protein 3 
                 0.0066 
                 0.2171 
                 1.3 
               
               
                 212232_at 
                 AB023231 
                 FNBP4 
                 formin binding 
                 0.0204 
                 0.5785 
                 1.3 
               
               
                   
                   
                   
                 protein 4 
                   
                   
                   
               
               
                 202231_at 
                 NM_006360 
                 PCID1 
                 PCI domain 
                 0.0048 
                 0.0923 
                 1.3 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                   
                   
                   
                 (herpesvirus entry 
                   
                   
                   
               
               
                   
                   
                   
                 mediator) 
                   
                   
                   
               
               
                 202769_at 
                 AW134535 
                 CCNG2 
                 cyclin G2 
                 0.0230 
                 0.3482 
                 1.3 
               
               
                 216221_s_at 
                 D87078 
                 PUM2 
                 pumilio homolog 2 
                 0.0020 
                 0.5905 
                 1.3 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 213093_at 
                 AI471375 
                 PRKCA 
                 protein kinase C, 
                 0.0006 
                 0.0721 
                 1.3 
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 201926_s_at 
                 BC001288 
                 CD55 
                 CD55 molecule, 
                 0.0261 
                 0.3374 
                 1.3 
               
               
                   
                   
                   
                 decay accelerating 
                   
                   
                   
               
               
                   
                   
                   
                 factor for 
                   
                   
                   
               
               
                   
                   
                   
                 complement 
                   
                   
                   
               
               
                   
                   
                   
                 (Cromer blood 
                   
                   
                   
               
               
                   
                   
                   
                 group) 
                   
                   
                   
               
               
                 218450_at 
                 NM_015987 
                 HEBP1 
                 heme binding 
                 0.0057 
                 0.0971 
                 1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 218379_at 
                 NM_016090 
                 RBM7 
                 RNA binding motif 
                 0.0013 
                 0.0274 
                 1.3 
               
               
                   
                   
                   
                 protein 7 
                   
                   
                   
               
               
                 212609_s_at 
                 U79271 
                 AKT3 
                 V-akt murine 
                 0.0054 
                 0.0969 
                 1.3 
               
               
                   
                   
                   
                 thymoma viral 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene homolog 
                   
                   
                   
               
               
                   
                   
                   
                 3 (protein kinase B, 
                   
                   
                   
               
               
                   
                   
                   
                 gamma) 
                   
                   
                   
               
               
                 215001_s_at 
                 AL161952 
                 GLUL 
                 glutamate- 
                 0.0245 
                 0.9178 
                 1.3 
               
               
                   
                   
                   
                 ammonia ligase 
                   
                   
                   
               
               
                   
                   
                   
                 (glutamine 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase) 
                   
                   
                   
               
               
                 209120_at 
                 AL037401 
                 NR2F2 
                 nuclear receptor 
                 0.0147 
                 0.5417 
                 1.3 
               
               
                   
                   
                   
                 subfamily 2, group 
                   
                   
                   
               
               
                   
                   
                   
                 F, member 2 
                   
                   
                   
               
               
                 221593_s_at 
                 BC001663 
                 RPL31 
                 ribosomal protein 
                 0.0170 
                 0.1235 
                 1.3 
               
               
                   
                   
                   
                 L31 
                   
                   
                   
               
               
                 212591_at 
                 AA887480 
                 RBM34 
                 RNA binding motif 
                 0.0130 
                 0.1604 
                 1.3 
               
               
                   
                   
                   
                 protein 34 
                   
                   
                   
               
               
                 207719_x_at 
                 NM_014812 
                 CEP170 
                 centrosomal 
                 0.0293 
                 0.3400 
                 1.3 
               
               
                   
                   
                   
                 protein 170 kDa 
                   
                   
                   
               
               
                 205163_at 
                 NM_013292 
                 MYLPF 
                 fast skeletal 
                 0.0118 
                 0.1064 
                 1.3 
               
               
                   
                   
                   
                 myosin light chain 2 
                   
                   
                   
               
               
                 213136_at 
                 AI828880 
                 PTPN2 
                 protein tyrosine 
                 0.0039 
                 0.2891 
                 1.3 
               
               
                   
                   
                   
                 phosphatase, non- 
                   
                   
                   
               
               
                   
                   
                   
                 receptor type 2 
                   
                   
                   
               
               
                 213750_at 
                 AA928506 
                 — 
                 Full length insert 
                 0.0015 
                 0.0274 
                 1.3 
               
               
                   
                   
                   
                 cDNA YH77E09 
                   
                   
                   
               
               
                 201682_at 
                 NM_004279 
                 PMPCB 
                 peptidase 
                 0.0022 
                 0.4599 
                 1.3 
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 processing) beta 
                   
                   
                   
               
               
                 201448_at 
                 AL046419 
                 TIA1 
                 TIA1 cytotoxic 
                 0.0430 
                 0.4300 
                 1.3 
               
               
                   
                   
                   
                 granule-associated 
                   
                   
                   
               
               
                   
                   
                   
                 RNA binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 211962_s_at 
                 BG250310 
                 ZFP36L1 
                 zinc finger protein 
                 0.0471 
                 0.1958 
                 1.3 
               
               
                   
                   
                   
                 36, C3H type-like 1 
                   
                   
                   
               
               
                 214722_at 
                 AW516297 
                 NOTCH2NL 
                 Notch homolog 2 
                 0.0049 
                 0.2858 
                 1.3 
               
               
                   
                   
                   
                 ( Drosophila ) N- 
                   
                   
                   
               
               
                   
                   
                   
                 terminal like 
                   
                   
                   
               
               
                 202723_s_at 
                 AW117498 
                 FOXO1A 
                 forkhead box O1A 
                 0.0019 
                 0.3257 
                 1.3 
               
               
                   
                   
                   
                 (rhabdomyosarcoma) 
                   
                   
                   
               
               
                 217993_s_at 
                 NM_013283 
                 MAT2B 
                 methionine 
                 0.0018 
                 0.0583 
                 1.3 
               
               
                   
                   
                   
                 adenosyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 II, beta 
                   
                   
                   
               
               
                 216342_x_at 
                 AL121916 
                 LOC390183 
                 similar to 40S 
                 0.0037 
                 0.5394 
                 1.3 
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC442162 
                 S4, X isoform /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 40S 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S4, X isoform 
                   
                   
                   
               
               
                 217747_s_at 
                 NM_001013 
                 RPS9 
                 ribosomal protein 
                 0.0004 
                 0.0280 
                 1.3 
               
               
                   
                   
                   
                 S9 
                   
                   
                   
               
               
                 222229_x_at 
                 AL121871 
                 LOC392501 
                 similar to 60S 
                 0.0007 
                 0.0664 
                 1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L26 
                   
                   
                   
               
               
                 201812_s_at 
                 NM_019059 
                 TOMM7 
                 translocase of outer 
                 0.0077 
                 0.1777 
                 1.3 
               
               
                   
                   
                 /// 
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                 LOC201725 
                 membrane 7 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) /// 
                   
                   
                   
               
               
                   
                   
                   
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC201725 
                   
                   
                   
               
               
                 206506_s_at 
                 NM_003599 
                 SUPT3H 
                 suppressor of Ty 3 
                 0.0013 
                 0.0389 
                 1.3 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 204093_at 
                 NM_001239 
                 CCNH 
                 cyclin H 
                 0.0011 
                 0.0264 
                 1.3 
               
               
                 211967_at 
                 BG538627 
                 TMEM123 
                 transmembrane 
                 0.0049 
                 0.2276 
                 1.3 
               
               
                   
                   
                   
                 protein 123 
                   
                   
                   
               
               
                 212533_at 
                 X62048 
                 WEE1 
                 WEE1 homolog ( S. pombe ) 
                 0.0014 
                 0.0990 
                 1.3 
               
               
                 211713_x_at 
                 BC005832 
                 KIAA0101 
                 KIAA0101 /// 
                 0.0035 
                 0.0344 
                 1.3 
               
               
                   
                   
                   
                 KIAA0101 
                   
                   
                   
               
               
                 206169_x_at 
                 NM_025013 
                 ZC3H7B 
                 zinc finger CCCH- 
                 0.0199 
                 0.1897 
                 1.3 
               
               
                   
                   
                   
                 type containing 7B 
                   
                   
                   
               
               
                 221827_at 
                 BE788439 
                 RBCK1 
                 RanBP-type and 
                 0.0033 
                 0.1180 
                 1.3 
               
               
                   
                   
                   
                 C3HC4-type zinc 
                   
                   
                   
               
               
                   
                   
                   
                 finger containing 1 
                   
                   
                   
               
               
                 212462_at 
                 AU144267 
                 MYST4 
                 MYST histone 
                 0.0491 
                 0.9450 
                 1.3 
               
               
                   
                   
                   
                 acetyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (monocytic 
                   
                   
                   
               
               
                   
                   
                   
                 leukemia) 4 
                   
                   
                   
               
               
                 204369_at 
                 NM_006218 
                 PIK3CA 
                 phosphoinositide- 
                 0.0136 
                 0.1909 
                 1.3 
               
               
                   
                   
                   
                 3-kinase, catalytic, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha polypeptide 
                   
                   
                   
               
               
                 213438_at 
                 AA995925 
                 NFASC 
                 neurofascin 
                 0.0177 
                 0.0582 
                 1.3 
               
               
                   
                   
                   
                 homolog (chicken) 
                   
                   
                   
               
               
                 219001_s_at 
                 NM_024345 
                 WDR32 
                 WD repeat domain 
                 0.0159 
                 0.7542 
                 1.3 
               
               
                   
                   
                   
                 32 
                   
                   
                   
               
               
                 200023_s_at 
                 NM_003754 
                 EIF3S5 
                 eukaryotic 
                 0.0004 
                 0.0285 
                 1.3 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 5 epsilon, 
                   
                   
                   
               
               
                   
                   
                   
                 47 kDa /// 
                   
                   
                   
               
               
                   
                   
                   
                 eukaryotic 
                   
                   
                   
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 5 epsilon, 
                   
                   
                   
               
               
                   
                   
                   
                 47 kDa 
                   
                   
                   
               
               
                 202679_at 
                 NM_000271 
                 NPC1 
                 Niemann-Pick 
                 0.0280 
                 0.5043 
                 1.3 
               
               
                   
                   
                   
                 disease, type C1 
                   
                   
                   
               
               
                 221735_at 
                 H04342 
                 WDR48 
                 WD repeat domain 
                 0.0214 
                 0.1303 
                 1.3 
               
               
                   
                   
                   
                 48 
                   
                   
                   
               
               
                 205917_at 
                 NM_003417 
                 ZNF264 
                 zinc finger protein 
                 0.0289 
                 0.3938 
                 1.3 
               
               
                   
                   
                   
                 264 
                   
                   
                   
               
               
                 213483_at 
                 AK025679 
                 PPWD1 
                 peptidylprolyl 
                 0.0081 
                 0.3358 
                 1.3 
               
               
                   
                   
                   
                 isomerase domain 
                   
                   
                   
               
               
                   
                   
                   
                 and WD repeat 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 203255_at 
                 NM_018693 
                 FBXO11 
                 F-box protein 11 
                 0.0497 
                 0.1031 
                 1.3 
               
               
                 201652_at 
                 NM_006837 
                 COPS5 
                 COP9 constitutive 
                 0.0376 
                 0.1262 
                 1.3 
               
               
                   
                   
                   
                 photomorphogenic 
                   
                   
                   
               
               
                   
                   
                   
                 homolog subunit 5 
                   
                   
                   
               
               
                   
                   
                   
                 ( Arabidopsis ) 
                   
                   
                   
               
               
                 218499_at 
                 NM_016542 
                 RP6- 
                 serine/threonine 
                 0.0373 
                 0.3857 
                 1.3 
               
               
                   
                   
                 213H19.1 
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 MST4 
                   
                   
                   
               
               
                 216570_x_at 
                 AL096829 
                 LOC646417 
                 similar to 60S 
                 0.0055 
                 0.4385 
                 1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L29 (P23) 
                   
                   
                   
               
               
                 212265_at 
                 AL031781 
                 QKI 
                 quaking homolog, 
                 0.0235 
                 0.2288 
                 1.3 
               
               
                   
                   
                   
                 KH domain RNA 
                   
                   
                   
               
               
                   
                   
                   
                 binding (mouse) 
                   
                   
                   
               
               
                 213275_x_at 
                 W47179 
                 CTSB 
                 cathepsin B 
                 0.0154 
                 0.1777 
                 1.3 
               
               
                 208655_at 
                 BG530368 
                 CCNI 
                 Cyclin I 
                 0.0029 
                 0.1777 
                 1.3 
               
               
                 212416_at 
                 AV745949 
                 SCAMP1 
                 secretory carrier 
                 0.0035 
                 0.8372 
                 1.3 
               
               
                   
                   
                   
                 membrane protein 1 
                   
                   
                   
               
               
                 202026_at 
                 NM_003002 
                 SDHD 
                 succinate 
                 0.0181 
                 0.2574 
                 1.3 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 D, integral 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                 212897_at 
                 AI738802 
                 CDC2L6 
                 cell division cycle 
                 0.0031 
                 0.3399 
                 1.3 
               
               
                   
                   
                   
                 2-like 6 (CDK8- 
                   
                   
                   
               
               
                   
                   
                   
                 like) 
                   
                   
                   
               
               
                 201592_at 
                 NM_003756 
                 EIF3S3 
                 eukaryotic 
                 0.0016 
                 0.0564 
                 1.3 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 3 gamma, 
                   
                   
                   
               
               
                   
                   
                   
                 40 kDa 
                   
                   
                   
               
               
                 202076_at 
                 NM_001166 
                 BIRC2 
                 baculoviral IAP 
                 0.0033 
                 0.0770 
                 1.3 
               
               
                   
                   
                   
                 repeat-containing 2 
                   
                   
                   
               
               
                 217799_x_at 
                 NM_003344 
                 UBE2H 
                 ubiquitin- 
                 0.0304 
                 0.2586 
                 1.3 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2H 
                   
                   
                   
               
               
                   
                   
                   
                 (UBC8 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 200771_at 
                 NM_002293 
                 LAMC1 
                 laminin, gamma 1 
                 0.0012 
                 0.2016 
                 1.3 
               
               
                   
                   
                   
                 (formerly LAMB2) 
                   
                   
                   
               
               
                 202172_at 
                 BG035116 
                 VEZF1 
                 vascular 
                 0.0037 
                 0.2438 
                 1.3 
               
               
                   
                   
                   
                 endothelial zinc 
                   
                   
                   
               
               
                   
                   
                   
                 finger 1 
                   
                   
                   
               
               
                 213853_at 
                 AL050199 
                 DPH4 
                 DPH4, JJJ3 
                 0.0136 
                 0.0763 
                 1.3 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209242_at 
                 AL042588 
                 PEG3 
                 paternally 
                 0.0184 
                 0.8421 
                 1.3 
               
               
                   
                   
                   
                 expressed 3 
                   
                   
                   
               
               
                 212604_at 
                 AI937794 
                 MRPS31 
                 mitochondrial 
                 0.0044 
                 0.0424 
                 1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S31 
                   
                   
                   
               
               
                 209422_at 
                 AL109965 
                 PHF20 
                 PHD finger protein 
                 0.0173 
                 0.0571 
                 1.3 
               
               
                   
                   
                   
                 20 
                   
                   
                   
               
               
                 216380_x_at 
                 AC005011 
                 LOC728453 
                 similar to 40S 
                 0.0032 
                 0.7942 
                 1.3 
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC730288 
                 S28 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                 LOC730819 
                 protein S28 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 40S 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S28 
                   
                   
                   
               
               
                 213236_at 
                 AK025495 
                 SASH1 
                 SAM and SH3 
                 0.0035 
                 0.2189 
                 1.3 
               
               
                   
                   
                   
                 domain containing 1 
                   
                   
                   
               
               
                 213322_at 
                 AL031778 
                 C6orf130 
                 chromosome 6 
                 0.0449 
                 0.5982 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 130 
                   
                   
                   
               
               
                 205070_at 
                 NM_019071 
                 ING3 
                 inhibitor of growth 
                 0.0079 
                 0.0885 
                 1.3 
               
               
                   
                   
                   
                 family, member 3 
                   
                   
                   
               
               
                 204700_x_at 
                 NM_014388 
                 C1orf107 
                 chromosome 1 
                 0.0355 
                 0.5585 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 107 
                   
                   
                   
               
               
                 210095_s_at 
                 M31159 
                 IGFBP3 
                 insulin-like growth 
                 0.0091 
                 0.6408 
                 1.3 
               
               
                   
                   
                   
                 factor binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 3 
                   
                   
                   
               
               
                 222368_at 
                 AW972351 
                 — 
                 CDNA FLJ37098 
                 0.0041 
                 0.0383 
                 1.3 
               
               
                   
                   
                   
                 fis, clone 
                   
                   
                   
               
               
                   
                   
                   
                 BRACE2019004 
                   
                   
                   
               
               
                 219492_at 
                 NM_012110 
                 CHIC2 
                 cysteine-rich 
                 0.0254 
                 0.4819 
                 1.3 
               
               
                   
                   
                   
                 hydrophobic 
                   
                   
                   
               
               
                   
                   
                   
                 domain 2 
                   
                   
                   
               
               
                 200017_at 
                 NM_002954 
                 RPS27A 
                 ribosomal protein 
                 0.0019 
                 0.0719 
                 1.3 
               
               
                   
                   
                   
                 S27a /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S27a 
                   
                   
                   
               
               
                 214176_s_at 
                 AI348545 
                 PBXIP1 
                 Pre-B-cell 
                 0.0039 
                 0.1142 
                 1.3 
               
               
                   
                   
                   
                 leukemia 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 1 
                   
                   
                   
               
               
                 218972_at 
                 NM_018259 
                 TTC17 
                 tetratricopeptide 
                 0.0366 
                 0.5363 
                 1.3 
               
               
                   
                   
                   
                 repeat domain 17 
                   
                   
                   
               
               
                 211337_s_at 
                 BC000966 
                 76P 
                 gamma tubulin ring 
                 0.0225 
                 0.2023 
                 1.3 
               
               
                   
                   
                   
                 complex protein 
                   
                   
                   
               
               
                   
                   
                   
                 (76p gene) 
                   
                   
                   
               
               
                 202668_at 
                 BF001670 
                 EFNB2 
                 ephrin-B2 
                 0.0059 
                 0.0951 
                 1.3 
               
               
                 209620_s_at 
                 AB005289 
                 ABCB7 
                 ATP-binding 
                 0.0129 
                 0.2027 
                 1.3 
               
               
                   
                   
                   
                 cassette, sub- 
                   
                   
                   
               
               
                   
                   
                   
                 family B 
                   
                   
                   
               
               
                   
                   
                   
                 (MDR/TAP), 
                   
                   
                   
               
               
                   
                   
                   
                 member 7 
                   
                   
                   
               
               
                 212519_at 
                 AL518159 
                 UBE2E1 
                 ubiquitin- 
                 0.0098 
                 0.0900 
                 1.3 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2E 1 
                   
                   
                   
               
               
                   
                   
                   
                 (UBC4/5 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 203067_at 
                 NM_003477 
                 PDHX 
                 pyruvate 
                 0.0135 
                 0.3222 
                 1.3 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 complex, 
                   
                   
                   
               
               
                   
                   
                   
                 component X 
                   
                   
                   
               
               
                 219641_at 
                 NM_017996 
                 DET1 
                 de-etiolated 
                 0.0133 
                 0.8629 
                 1.3 
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Arabidopsis ) 
                   
                   
                   
               
               
                 206090_s_at 
                 NM_018662 
                 DISC1 
                 disrupted in 
                 0.0429 
                 0.7391 
                 1.3 
               
               
                   
                   
                   
                 schizophrenia 1 
                   
                   
                   
               
               
                 200741_s_at 
                 NM_001030 
                 RPS27 
                 ribosomal protein 
                 0.0020 
                 0.0582 
                 1.3 
               
               
                   
                   
                   
                 S27 
                   
                   
                   
               
               
                   
                   
                   
                 (metallopanstimulin 
                   
                   
                   
               
               
                   
                   
                   
                 1) 
                   
                   
                   
               
               
                 204587_at 
                 NM_003951 
                 SLC25A14 
                 solute carrier 
                 0.0055 
                 0.5404 
                 1.3 
               
               
                   
                   
                   
                 family 25 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 carrier, brain), 
                   
                   
                   
               
               
                   
                   
                   
                 member 14 
                   
                   
                   
               
               
                 202220_at 
                 NM_014949 
                 KIAA0907 
                 KIAA0907 
                 0.0018 
                 0.0746 
                 1.3 
               
               
                 213269_at 
                 N21541 
                 ZNF248 
                 zinc finger protein 
                 0.0112 
                 0.9344 
                 1.3 
               
               
                   
                   
                   
                 248 
                   
                   
                   
               
               
                 211257_x_at 
                 AF273049 
                 ZNF638 
                 zinc finger protein 
                 0.0157 
                 0.1090 
                 1.3 
               
               
                   
                   
                   
                 638 
                   
                   
                   
               
               
                 219147_s_at 
                 NM_017881 
                 C9orf95 
                 chromosome 9 
                 0.0147 
                 0.0770 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 95 
                   
                   
                   
               
               
                 202973_x_at 
                 NM_014883 
                 FAM13A1 
                 family with 
                 0.0169 
                 0.6932 
                 1.3 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 13, member A1 
                   
                   
                   
               
               
                 213883_s_at 
                 AA012917 
                 TM2D1 
                 TM2 domain 
                 0.0148 
                 0.1709 
                 1.3 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 205370_x_at 
                 NM_001918 
                 DBT 
                 dihydrolipoamide 
                 0.0034 
                 0.1235 
                 1.3 
               
               
                   
                   
                   
                 branched chain 
                   
                   
                   
               
               
                   
                   
                   
                 transacylase E2 
                   
                   
                   
               
               
                 219571_s_at 
                 NM_016265 
                 ZNF12 
                 zinc finger protein 
                 0.0223 
                 0.0935 
                 1.3 
               
               
                   
                   
                   
                 12 
                   
                   
                   
               
               
                 219133_at 
                 NM_017897 
                 OXSM 
                 3-oxoacyl-ACP 
                 0.0183 
                 0.5794 
                 1.3 
               
               
                   
                   
                   
                 synthase, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 220988_s_at 
                 NM_030945 
                 C1QTNF3 
                 C1q and tumor 
                 0.0079 
                 0.2302 
                 1.3 
               
               
                   
                   
                   
                 necrosis factor 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 C1q and tumor 
                   
                   
                   
               
               
                   
                   
                   
                 necrosis factor 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 3 
                   
                   
                   
               
               
                 202454_s_at 
                 NM_001982 
                 ERBB3 
                 v-erb-b2 
                 0.0180 
                 0.5119 
                 1.3 
               
               
                   
                   
                   
                 erythroblastic 
                   
                   
                   
               
               
                   
                   
                   
                 leukemia viral 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene homolog 
                   
                   
                   
               
               
                   
                   
                   
                 3 (avian) 
                   
                   
                   
               
               
                 203831_at 
                 NM_014925 
                 R3HDM2 
                 R3H domain 
                 0.0183 
                 0.7758 
                 1.3 
               
               
                   
                   
                   
                 containing 2 
                   
                   
                   
               
               
                 210028_s_at 
                 AF125507 
                 ORC3L 
                 origin recognition 
                 0.0029 
                 0.2383 
                 1.3 
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 3-like (yeast) 
                   
                   
                   
               
               
                 202386_s_at 
                 NM_019081 
                 KIAA0430 
                 KIAA0430 
                 0.0377 
                 0.3255 
                 1.3 
               
               
                 215628_x_at 
                 AL049285 
                 PPP2CA 
                 Protein 
                 0.0079 
                 0.4496 
                 1.3 
               
               
                   
                   
                   
                 phosphatase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (formerly 2A), 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha isoform 
                   
                   
                   
               
               
                 212018_s_at 
                 AK000822 
                 RSL1D1 
                 ribosomal L1 
                 0.0054 
                 0.3191 
                 1.3 
               
               
                   
                   
                   
                 domain containing 1 
                   
                   
                   
               
               
                 203667_at 
                 NM_004607 
                 TBCA 
                 tubulin folding 
                 0.0025 
                 0.0280 
                 1.3 
               
               
                   
                   
                   
                 cofactor A 
                   
                   
                   
               
               
                 212327_at 
                 AK026815 
                 DKFZP686A01247 
                 hypothetical 
                 0.0038 
                 0.4265 
                 1.3 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212334_at 
                 BE880245 
                 GNS 
                 glucosamine (N- 
                 0.0218 
                 0.1233 
                 1.3 
               
               
                   
                   
                   
                 acetyl)-6-sulfatase 
                   
                   
                   
               
               
                   
                   
                   
                 (Sanfilippo disease 
                   
                   
                   
               
               
                   
                   
                   
                 IIID) 
                   
                   
                   
               
               
                 201164_s_at 
                 BG474429 
                 RNF6 /// 
                 ring finger protein 
                 0.0026 
                 0.2690 
                 1.3 
               
               
                   
                   
                 PUM1 
                 (C3H2C3 type) 6 
                   
                   
                   
               
               
                   
                   
                   
                 /// pumilio 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 200010_at 
                 NM_000975 
                 RPL11 
                 Ribosomal protein 
                 0.0019 
                 0.0441 
                 1.3 
               
               
                   
                   
                   
                 L11 /// Ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L11 
                   
                   
                   
               
               
                 222034_at 
                 AA443762 
                 GNB2L1 
                 Guanine nucleotide 
                 0.0167 
                 0.1744 
                 1.3 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein), beta 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 2-like 1 
                   
                   
                   
               
               
                 221207_s_at 
                 NM_015678 
                 NBEA 
                 neurobeachin 
                 0.0076 
                 0.1564 
                 1.3 
               
               
                 222122_s_at 
                 BG403671 
                 THOC2 
                 THO complex 2 
                 0.0494 
                 0.2813 
                 1.3 
               
               
                 213168_at 
                 AU145005 
                 SP3 
                 Sp3 transcription 
                 0.0257 
                 0.4889 
                 1.3 
               
               
                   
                   
                   
                 factor 
                   
                   
                   
               
               
                 221112_at 
                 NM_017416 
                 IL1RAPL2 
                 interleukin 1 
                 0.0483 
                 0.9794 
                 1.3 
               
               
                   
                   
                   
                 receptor accessory 
                   
                   
                   
               
               
                   
                   
                   
                 protein-like 2 
                   
                   
                   
               
               
                 213229_at 
                 BF590131 
                 DICER1 
                 Dicer1, Dcr-1 
                 0.0454 
                 0.0372 
                 1.3 
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 221702_s_at 
                 AF353992 
                 TM2D3 
                 TM2 domain 
                 0.0049 
                 0.1787 
                 1.3 
               
               
                   
                   
                   
                 containing 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 TM2 domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 200897_s_at 
                 NM_016081 
                 PALLD 
                 palladin, 
                 0.0042 
                 0.0476 
                 1.3 
               
               
                   
                   
                   
                 cytoskeletal 
                   
                   
                   
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                 203704_s_at 
                 AW118862 
                 — 
                 — 
                 0.0495 
                 0.2054 
                 1.3 
               
               
                 213065_at 
                 AB011118 
                 CCDC131 
                 coiled-coil domain 
                 0.0233 
                 0.9011 
                 1.3 
               
               
                   
                   
                   
                 containing 131 
                   
                   
                   
               
               
                 207283_at 
                 NM_020217 
                 RPL23AP13 
                 ribosomal protein 
                 0.0489 
                 0.6649 
                 1.3 
               
               
                   
                   
                   
                 L23a pseudogene 
                   
                   
                   
               
               
                   
                   
                   
                 13 
                   
                   
                   
               
               
                 202960_s_at 
                 NM_000255 
                 MUT 
                 methylmalonyl 
                 0.0361 
                 0.1791 
                 1.3 
               
               
                   
                   
                   
                 Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 mutase 
                   
                   
                   
               
               
                 221486_at 
                 AF067170 
                 ENSA 
                 endosulfine alpha 
                 0.0113 
                 0.1876 
                 1.3 
               
               
                 212558_at 
                 BF508662 
                 SPRY1 
                 sprouty homolog 1, 
                 0.0376 
                 0.8925 
                 1.3 
               
               
                   
                   
                   
                 antagonist of FGF 
                   
                   
                   
               
               
                   
                   
                   
                 signaling 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 203481_at 
                 AI655902 
                 C10orf6 
                 chromosome 10 
                 0.0137 
                 0.0636 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 6 
                   
                   
                   
               
               
                 214281_s_at 
                 AA524525 
                 RCHY1 
                 ring finger and 
                 0.0048 
                 0.0861 
                 1.3 
               
               
                   
                   
                   
                 CHY zinc finger 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 1 
                   
                   
                   
               
               
                 200062_s_at 
                 L05095 
                 RPL30 
                 ribosomal protein 
                 0.0011 
                 0.0383 
                 1.3 
               
               
                   
                   
                   
                 L30 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L30 
                   
                   
                   
               
               
                 203221_at 
                 AI758763 
                 TLE1 
                 transducin-like 
                 0.0020 
                 0.0387 
                 1.3 
               
               
                   
                   
                   
                 enhancer of split 1 
                   
                   
                   
               
               
                   
                   
                   
                 (E(sp1) homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 
                   Drosophila) 
                 
                   
                   
                   
               
               
                 218628_at 
                 NM_016053 
                 CCDC53 
                 coiled-coil domain 
                 0.0257 
                 0.0506 
                 1.3 
               
               
                   
                   
                   
                 containing 53 
                   
                   
                   
               
               
                 214707_x_at 
                 AB002326 
                 ALMS1 
                 Alstrom syndrome 1 
                 0.0021 
                 0.0329 
                 1.3 
               
               
                 212758_s_at 
                 AI373166 
                 TCF8 
                 transcription factor 
                 0.0166 
                 0.0274 
                 1.3 
               
               
                   
                   
                   
                 8 (represses 
                   
                   
                   
               
               
                   
                   
                   
                 interleukin 2 
                   
                   
                   
               
               
                   
                   
                   
                 expression) 
                   
                   
                   
               
               
                 202557_at 
                 AI718418 
                 STCH 
                 stress 70 protein 
                 0.0144 
                 0.1063 
                 1.3 
               
               
                   
                   
                   
                 chaperone, 
                   
                   
                   
               
               
                   
                   
                   
                 microsome- 
                   
                   
                   
               
               
                   
                   
                   
                 associated, 60 kDa 
                   
                   
                   
               
               
                 208246_x_at 
                 NM_017618 
                 — 
                 CDNA FLJ20006 
                 0.0043 
                 0.1221 
                 1.3 
               
               
                   
                   
                   
                 fis, clone 
                   
                   
                   
               
               
                   
                   
                   
                 ADKA02694 
                   
                   
                   
               
               
                 202766_s_at 
                 NM_000138 
                 FBN1 
                 fibrillin 1 
                 0.0129 
                 0.6308 
                 1.3 
               
               
                 201830_s_at 
                 NM_005863 
                 NET1 
                 neuroepithelial cell 
                 0.0180 
                 0.0835 
                 1.3 
               
               
                   
                   
                   
                 transforming gene 1 
                   
                   
                   
               
               
                 212805_at 
                 AB002365 
                 KIAA0367 
                 KIAA0367 
                 0.0344 
                 0.3786 
                 1.3 
               
               
                 207467_x_at 
                 NM_001750 
                 CAST 
                 calpastatin 
                 0.0122 
                 0.0990 
                 1.3 
               
               
                 201502_s_at 
                 AI078167 
                 NFKBIA 
                 nuclear factor of 
                 0.0044 
                 0.0499 
                 1.3 
               
               
                   
                   
                   
                 kappa light 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide gene 
                   
                   
                   
               
               
                   
                   
                   
                 enhancer in B-cells 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor, alpha 
                   
                   
                   
               
               
                 209111_at 
                 BC004155 
                 RNF5 
                 ring finger protein 5 
                 0.0072 
                 0.9883 
                 1.3 
               
               
                 211971_s_at 
                 AI653608 
                 LRPPRC 
                 leucine-rich PPR- 
                 0.0080 
                 0.1196 
                 1.3 
               
               
                   
                   
                   
                 motif containing 
                   
                   
                   
               
               
                 210389_x_at 
                 BC000258 
                 TUBD1 
                 tubulin, delta 1 
                 0.0199 
                 0.6862 
                 1.3 
               
               
                 212982_at 
                 AI621223 
                 ZDHHC17 
                 zinc finger, 
                 0.0496 
                 0.4017 
                 1.3 
               
               
                   
                   
                   
                 DHHC-type 
                   
                   
                   
               
               
                   
                   
                   
                 containing 17 
                   
                   
                   
               
               
                 210946_at 
                 AF014403 
                 PPAP2A 
                 phosphatidic acid 
                 0.0123 
                 0.2350 
                 1.3 
               
               
                   
                   
                   
                 phosphatase type 
                   
                   
                   
               
               
                   
                   
                   
                 2A 
                   
                   
                   
               
               
                 203095_at 
                 NM_002453 
                 MTIF2 
                 mitochondrial 
                 0.0312 
                 0.2324 
                 1.3 
               
               
                   
                   
                   
                 translational 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 2 
                   
                   
                   
               
               
                 201857_at 
                 NM_016107 
                 ZFR 
                 zinc finger RNA 
                 0.0069 
                 0.0656 
                 1.3 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 209390_at 
                 AF013168 
                 TSC1 
                 tuberous sclerosis 1 
                 0.0005 
                 0.0554 
                 1.3 
               
               
                 213313_at 
                 AI922519 
                 RABGAP1 
                 RAB GTPase 
                 0.0129 
                 0.2904 
                 1.3 
               
               
                   
                   
                   
                 activating protein 1 
                   
                   
                   
               
               
                 209065_at 
                 BC005230 
                 UQCRB 
                 ubiquinol- 
                 0.0314 
                 0.1143 
                 1.3 
               
               
                   
                   
                   
                 cytochrome c 
                   
                   
                   
               
               
                   
                   
                   
                 reductase binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212244_at 
                 AL050091 
                 GRINL1A 
                 glutamate receptor, 
                 0.0198 
                 0.4925 
                 1.3 
               
               
                   
                   
                 /// Gcom1 
                 ionotropic, N- 
                   
                   
                   
               
               
                   
                   
                   
                 methyl D- 
                   
                   
                   
               
               
                   
                   
                   
                 aspartate-like 1A 
                   
                   
                   
               
               
                   
                   
                   
                 /// GRINL1A 
                   
                   
                   
               
               
                   
                   
                   
                 combined protein 
                   
                   
                   
               
               
                 208021_s_at 
                 NM_002913 
                 RFC1 
                 replication factor C 
                 0.0224 
                 0.4152 
                 1.3 
               
               
                   
                   
                   
                 (activator 1) 1, 
                   
                   
                   
               
               
                   
                   
                   
                 145 kDa /// 
                   
                   
                   
               
               
                   
                   
                   
                 replication factor C 
                   
                   
                   
               
               
                   
                   
                   
                 (activator 1) 1, 
                   
                   
                   
               
               
                   
                   
                   
                 145 kDa 
                   
                   
                   
               
               
                 212542_s_at 
                 BF224151 
                 PHIP 
                 pleckstrin 
                 0.0244 
                 0.3957 
                 1.3 
               
               
                   
                   
                   
                 homology domain 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 213657_s_at 
                 BE858194 
                 ZNF710 
                 Zinc finger protein 
                 0.0202 
                 0.5147 
                 1.3 
               
               
                   
                   
                 /// 
                 710 /// MRNA full 
                   
                   
                   
               
               
                   
                   
                 DOCK4 
                 length insert cDNA 
                   
                   
                   
               
               
                   
                   
                   
                 clone 
                   
                   
                   
               
               
                   
                   
                   
                 EUROIMAGE 
                   
                   
                   
               
               
                   
                   
                   
                 375854 /// 
                   
                   
                   
               
               
                   
                   
                   
                 Dedicator of 
                   
                   
                   
               
               
                   
                   
                   
                 cytokinesis 4 
                   
                   
                   
               
               
                 212226_s_at 
                 AA628586 
                 PPAP2B 
                 phosphatidic acid 
                 0.0253 
                 0.1768 
                 1.3 
               
               
                   
                   
                   
                 phosphatase type 
                   
                   
                   
               
               
                   
                   
                   
                 2B 
                   
                   
                   
               
               
                 203038_at 
                 NM_002844 
                 PTPRK 
                 protein tyrosine 
                 0.0050 
                 0.1699 
                 1.3 
               
               
                   
                   
                   
                 phosphatase, 
                   
                   
                   
               
               
                   
                   
                   
                 receptor type, K 
                   
                   
                   
               
               
                 201648_at 
                 AL039831 
                 JAK1 
                 Janus kinase 1 (a 
                 0.0364 
                 0.4317 
                 1.3 
               
               
                   
                   
                   
                 protein tyrosine 
                   
                   
                   
               
               
                   
                   
                   
                 kinase) 
                   
                   
                   
               
               
                 213542_at 
                 AI246730 
                 ZNF710 
                 zinc finger protein 
                 0.0146 
                 0.3325 
                 1.3 
               
               
                   
                   
                   
                 710 
                   
                   
                   
               
               
                 209684_at 
                 AL136924 
                 RIN2 
                 Ras and Rab 
                 0.0097 
                 0.1105 
                 1.3 
               
               
                   
                   
                   
                 interactor 2 
                   
                   
                   
               
               
                 214003_x_at 
                 BF184532 
                 RPS20 
                 ribosomal protein 
                 0.0009 
                 0.0252 
                 1.3 
               
               
                   
                   
                   
                 S20 
                   
                   
                   
               
               
                 218852_at 
                 NM_017917 
                 C14orf10 
                 chromosome 14 
                 0.0433 
                 0.1844 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 10 
                   
                   
                   
               
               
                 212893_at 
                 AL080063 
                 ZZZ3 
                 zinc finger, ZZ- 
                 0.0186 
                 0.1134 
                 1.3 
               
               
                   
                   
                   
                 type containing 3 
                   
                   
                   
               
               
                 218263_s_at 
                 NM_021211 
                 ZBED5 
                 zinc finger, BED- 
                 0.0016 
                 0.0395 
                 1.3 
               
               
                   
                   
                   
                 type containing 5 
                   
                   
                   
               
               
                 203301_s_at 
                 NM_021145 
                 DMTF1 
                 cyclin D binding 
                 0.0400 
                 0.4154 
                 1.3 
               
               
                   
                   
                   
                 myb-like 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 1 
                   
                   
                   
               
               
                 207730_x_at 
                 NM_017932 
                 HDGF2 
                 Hepatoma-derived 
                 0.0045 
                 0.0473 
                 1.3 
               
               
                   
                   
                   
                 growth factor- 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 2 
                   
                   
                   
               
               
                 202302_s_at 
                 NM_023012 
                 FLJ11021 
                 similar to splicing 
                 0.0085 
                 0.1061 
                 1.3 
               
               
                   
                   
                   
                 factor, 
                   
                   
                   
               
               
                   
                   
                   
                 arginine/serine-rich 4 
                   
                   
                   
               
               
                 203020_at 
                 NM_014857 
                 RABGAP1L 
                 RAB GTPase 
                 0.0038 
                 0.2687 
                 1.3 
               
               
                   
                   
                   
                 activating protein 
                   
                   
                   
               
               
                   
                   
                   
                 1-like 
                   
                   
                   
               
               
                 220352_x_at 
                 NM_024305 
                 — 
                 — 
                 0.0021 
                 0.1437 
                 1.3 
               
               
                 211452_x_at 
                 AF130054 
                 LRRFIP1 
                 leucine rich repeat 
                 0.0066 
                 0.0547 
                 1.3 
               
               
                   
                   
                   
                 (in FLII) 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 1 
                   
                   
                   
               
               
                 200810_s_at 
                 NM_001280 
                 CIRBP 
                 cold inducible 
                 0.0036 
                 0.0793 
                 1.3 
               
               
                   
                   
                   
                 RNA binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212104_s_at 
                 N95026 
                 RBM9 
                 RNA binding motif 
                 0.0045 
                 0.1200 
                 1.3 
               
               
                   
                   
                   
                 protein 9 
                   
                   
                   
               
               
                 213839_at 
                 AW028110 
                 KIAA0500 
                 KIAA0500 protein 
                 0.0297 
                 0.2545 
                 1.3 
               
               
                 202968_s_at 
                 Y09216 
                 DYRK2 
                 dual-specificity 
                 0.0395 
                 0.1646 
                 1.3 
               
               
                   
                   
                   
                 tyrosine-(Y)- 
                   
                   
                   
               
               
                   
                   
                   
                 phosphorylation 
                   
                   
                   
               
               
                   
                   
                   
                 regulated kinase 2 
                   
                   
                   
               
               
                 213074_at 
                 BG545769 
                 IRAK1BP1 
                 Interleukin-1 
                 0.0314 
                 0.6649 
                 1.3 
               
               
                   
                   
                   
                 receptor-associated 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 1 binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 202623_at 
                 NM_018453 
                 C14orf11 
                 chromosome 14 
                 0.0073 
                 0.1164 
                 1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 11 
                   
                   
                   
               
               
                 213048_s_at 
                 W26593 
                 SET 
                 SET translocation 
                 0.0024 
                 0.0197 
                 1.3 
               
               
                   
                   
                   
                 (myeloid leukemia- 
                   
                   
                   
               
               
                   
                   
                   
                 associated) 
                   
                   
                   
               
               
                 219392_x_at 
                 NM_018304 
                 PRR11 
                 proline rich 11 
                 0.0058 
                 0.1864 
                 1.3 
               
               
                 201588_at 
                 NM_004786 
                 TXNL1 
                 thioredoxin-like 1 
                 0.0047 
                 0.0284 
                 1.3 
               
               
                 200026_at 
                 NM_000995 
                 RPL34 /// 
                 ribosomal protein 
                 0.0044 
                 0.0681 
                 1.3 
               
               
                   
                   
                 LOC342994 
                 L34 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein L34 /// 
                   
                   
                   
               
               
                   
                   
                 LOC651249 
                 similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC729536 
                 L34 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC731916 
                 L34 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 /// 
                   
                   
                   
               
               
                   
                   
                   
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC729536 /// 
                   
                   
                   
               
               
                   
                   
                   
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC729536 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 
                   
                   
                   
               
               
                 213328_at 
                 AI936517 
                 NEK1 
                 NIMA (never in 
                 0.0285 
                 0.0844 
                 1.3 
               
               
                   
                   
                   
                 mitosis gene a)- 
                   
                   
                   
               
               
                   
                   
                   
                 related kinase 1 
                   
                   
                   
               
               
                 207616_s_at 
                 NM_004180 
                 TANK 
                 TRAF family 
                 0.0256 
                 0.2643 
                 1.3 
               
               
                   
                   
                   
                 member-associated 
                   
                   
                   
               
               
                   
                   
                   
                 NFKB activator 
                   
                   
                   
               
               
                 217797_at 
                 NM_016406 
                 UFC1 
                 ubiquitin-fold 
                 0.0025 
                 0.0646 
                 1.3 
               
               
                   
                   
                   
                 modifier 
                   
                   
                   
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme 1 
                   
                   
                   
               
               
                 222244_s_at 
                 AK000749 
                 TUG1 
                 taurine upregulated 
                 0.0055 
                 0.1914 
                 1.3 
               
               
                   
                   
                   
                 gene 1 
                   
                   
                   
               
               
                 202673_at 
                 NM_003859 
                 DPM1 
                 dolichyl-phosphate 
                 0.0116 
                 0.0642 
                 1.3 
               
               
                   
                   
                   
                 mannosyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 1, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit 
                   
                   
                   
               
               
                 204688_at 
                 NM_003919 
                 SGCE 
                 sarcoglycan, 
                 0.0027 
                 0.1571 
                 1.3 
               
               
                   
                   
                   
                 epsilon 
                   
                   
                   
               
               
                 207943_x_at 
                 NM_006718 
                 PLAGL1 
                 pleiomorphic 
                 0.0133 
                 0.6838 
                 1.3 
               
               
                   
                   
                   
                 adenoma gene-like 1 
                   
                   
                   
               
               
                 203044_at 
                 NM_014918 
                 CHSY1 
                 carbohydrate 
                 0.0272 
                 0.0951 
                 1.3 
               
               
                   
                   
                   
                 (chondroitin) 
                   
                   
                   
               
               
                   
                   
                   
                 synthase 1 
                   
                   
                   
               
               
                 201758_at 
                 NM_006292 
                 TSG101 
                 tumor 
                 0.0088 
                 0.1664 
                 1.3 
               
               
                   
                   
                   
                 susceptibility gene 
                   
                   
                   
               
               
                   
                   
                   
                 101 
                   
                   
                   
               
               
                 213531_s_at 
                 AI040009 
                 RAB3GAP1 
                 RAB3 GTPase 
                 0.0046 
                 0.7605 
                 1.3 
               
               
                   
                   
                   
                 activating protein 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 1 
                   
                   
                   
               
               
                   
                   
                   
                 (catalytic) 
                   
                   
                   
               
               
                 218598_at 
                 NM_021930 
                 RINT1 
                 RAD50 interactor 1 
                 0.0193 
                 0.2781 
                 1.3 
               
               
                 214670_at 
                 AA653300 
                 ZKSCAN1 
                 zinc finger with 
                 0.0302 
                 0.3630 
                 1.3 
               
               
                   
                   
                   
                 KRAB and SCAN 
                   
                   
                   
               
               
                   
                   
                   
                 domains 1 
                   
                   
                   
               
               
                 218989_x_at 
                 NM_022902 
                 SLC30A5 
                 solute carrier 
                 0.0118 
                 0.0958 
                 1.3 
               
               
                   
                   
                   
                 family 30 (zinc 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 5 
                   
                   
                   
               
               
                 200937_s_at 
                 NM_000969 
                 RPL5 
                 ribosomal protein 
                 0.0011 
                 0.0539 
                 1.3 
               
               
                   
                   
                   
                 L5 
                   
                   
                   
               
               
                 213015_at 
                 BF448315 
                 — 
                 ARTC1 mRNA, 
                 0.0072 
                 0.0197 
                 1.3 
               
               
                   
                   
                   
                 complete sequence 
                   
                   
                   
               
               
                 211228_s_at 
                 AF085736 
                 RAD17 
                 RAD17 homolog 
                 0.0082 
                 0.2369 
                 1.3 
               
               
                   
                   
                   
                 ( S. pombe ) 
                   
                   
                   
               
               
                 209505_at 
                 AI951185 
                 NR2F1 
                 Nuclear receptor 
                 0.0237 
                 0.7005 
                 1.3 
               
               
                   
                   
                   
                 subfamily 2, group 
                   
                   
                   
               
               
                   
                   
                   
                 F, member 1 
                   
                   
                   
               
               
                 204457_s_at 
                 NM_002048 
                 GAS1 
                 growth arrest- 
                 0.0055 
                 0.1142 
                 1.3 
               
               
                   
                   
                   
                 specific 1 
                   
                   
                   
               
               
                 212596_s_at 
                 AJ010070 
                 HMG2L1 
                 high-mobility 
                 0.0205 
                 0.2332 
                 1.3 
               
               
                   
                   
                   
                 group protein 2- 
                   
                   
                   
               
               
                   
                   
                   
                 like 1 
                   
                   
                   
               
               
                 201256_at 
                 NM_004718 
                 COX7A2L 
                 cytochrome c 
                 0.0015 
                 0.0271 
                 1.3 
               
               
                   
                   
                   
                 oxidase subunit 
                   
                   
                   
               
               
                   
                   
                   
                 VIIa polypeptide 2 
                   
                   
                   
               
               
                   
                   
                   
                 like 
                   
                   
                   
               
               
                 205051_s_at 
                 NM_000222 
                 KIT 
                 v-kit Hardy- 
                 0.0500 
                 0.3862 
                 1.3 
               
               
                   
                   
                   
                 Zuckerman 4 feline 
                   
                   
                   
               
               
                   
                   
                   
                 sarcoma viral 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene homolog 
                   
                   
                   
               
               
                 214739_at 
                 AI357539 
                 LRCH3 
                 leucine-rich repeats 
                 0.0255 
                 0.3342 
                 1.3 
               
               
                   
                   
                   
                 and calponin 
                   
                   
                   
               
               
                   
                   
                   
                 homology (CH) 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 3 
                   
                   
                   
               
               
                 201406_at 
                 NM_021029 
                 RPL36A 
                 ribosomal protein 
                 0.0039 
                 0.1666 
                 1.3 
               
               
                   
                   
                 /// 
                 L36a /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC729362 
                 large subunit 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L36a 
                   
                   
                   
               
               
                 208986_at 
                 AL559478 
                 TCF12 
                 transcription factor 
                 0.0085 
                 0.1013 
                 1.3 
               
               
                   
                   
                   
                 12 (HTF4, helix- 
                   
                   
                   
               
               
                   
                   
                   
                 loop-helix 
                   
                   
                   
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factors 4) 
                   
                   
                   
               
               
                 200743_s_at 
                 NM_000391 
                 TPP1 
                 tripeptidyl 
                 0.0024 
                 0.3558 
                 1.3 
               
               
                   
                   
                   
                 peptidase I 
                   
                   
                   
               
               
                 204725_s_at 
                 NM_006153 
                 NCK1 
                 NCK adaptor 
                 0.0084 
                 0.2949 
                 1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 220760_x_at 
                 NM_024733 
                 ZNF665 
                 zinc finger protein 
                 0.0279 
                 0.2927 
                 1.3 
               
               
                   
                   
                   
                 665 
                   
                   
                   
               
               
                 200888_s_at 
                 NM_000978 
                 RPL23 
                 ribosomal protein 
                 0.0031 
                 0.1288 
                 1.3 
               
               
                   
                   
                   
                 L23 
                   
                   
                   
               
               
                 214257_s_at 
                 AA890010 
                 SEC22B 
                 SEC22 vesicle 
                 0.0340 
                 0.0759 
                 1.3 
               
               
                   
                   
                   
                 trafficking protein 
                   
                   
                   
               
               
                   
                   
                   
                 homolog B ( S. cerevisiae ) 
                   
                   
                   
               
               
                 202811_at 
                 NM_006463 
                 STAMBP 
                 STAM binding 
                 0.0479 
                 0.1820 
                 1.3 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 213685_at 
                 AA830143 
                 — 
                 Gene from PAC 
                 0.0170 
                 0.2067 
                 1.3 
               
               
                   
                   
                   
                 886K2, 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 1 
                   
                   
                   
               
               
                 208936_x_at 
                 AF074000 
                 LGALS8 
                 lectin, galactoside- 
                 0.0267 
                 0.5425 
                 1.3 
               
               
                   
                   
                   
                 binding, soluble, 8 
                   
                   
                   
               
               
                   
                   
                   
                 (galectin 8) 
                   
                   
                   
               
               
                 201831_s_at 
                 BE875592 
                 PAK1 /// 
                 p21/Cdc42/Rac1- 
                 0.0222 
                 0.2437 
                 1.3 
               
               
                   
                   
                 VDP 
                 activated kinase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (STE20 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) /// vesicle 
                   
                   
                   
               
               
                   
                   
                   
                 docking protein 
                   
                   
                   
               
               
                   
                   
                   
                 p115 
                   
                   
                   
               
               
                 209835_x_at 
                 BC004372 
                 CD44 
                 CD44 molecule 
                 0.0124 
                 0.2180 
                 1.3 
               
               
                   
                   
                   
                 (Indian blood 
                   
                   
                   
               
               
                   
                   
                   
                 group) 
                   
                   
                   
               
               
                 220176_at 
                 NM_025152 
                 NUBPL 
                 nucleotide binding 
                 0.0495 
                 0.9762 
                 1.3 
               
               
                   
                   
                   
                 protein-like 
                   
                   
                   
               
               
                 200038_s_at 
                 NM_000985 
                 RPL17 
                 ribosomal protein 
                 0.0019 
                 0.0400 
                 1.3 
               
               
                   
                   
                   
                 L17 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L17 
                   
                   
                   
               
               
                 201989_s_at 
                 AL529409 
                 CREBL2 
                 cAMP responsive 
                 0.0147 
                 0.9018 
                 1.3 
               
               
                   
                   
                   
                 element binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein-like 2 
                   
                   
                   
               
               
                 207513_s_at 
                 NM_003452 
                 ZNF189 
                 zinc finger protein 
                 0.0252 
                 0.1180 
                 1.3 
               
               
                   
                   
                   
                 189 
                   
                   
                   
               
               
                 217313_at 
                 AC004692 
                 — 
                 — 
                 0.0166 
                 0.8256 
                 1.3 
               
               
                 218549_s_at 
                 NM_016033 
                 FAM82B 
                 family with 
                 0.0235 
                 0.0666 
                 1.3 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 82, member B 
                   
                   
                   
               
               
                 217579_x_at 
                 AW301806 
                 ARL6IP2 
                 ADP-ribosylation 
                 0.0069 
                 0.0770 
                 1.3 
               
               
                   
                   
                   
                 factor-like 6 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 2 
                   
                   
                   
               
               
                 203240_at 
                 NM_003890 
                 FCGBP 
                 Fc fragment of IgG 
                 0.0085 
                 0.1142 
                 1.3 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 217833_at 
                 AL520908 
                 SYNCRIP 
                 synaptotagmin 
                 0.0054 
                 0.0968 
                 1.3 
               
               
                   
                   
                   
                 binding, 
                   
                   
                   
               
               
                   
                   
                   
                 cytoplasmic RNA 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 215529_x_at 
                 AI590053 
                 DIP2A 
                 DIP2 disco- 
                 0.0146 
                 0.1925 
                 1.3 
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 2 homolog A 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 210774_s_at 
                 AL162047 
                 NCOA4 
                 nuclear receptor 
                 0.0057 
                 0.0763 
                 1.3 
               
               
                   
                   
                   
                 coactivator 4 
                   
                   
                   
               
               
                 200090_at 
                 BG168896 
                 FNTA 
                 farnesyltransferase, 
                 0.0047 
                 0.4557 
                 1.3 
               
               
                   
                   
                   
                 CAAX box, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 /// 
                   
                   
                   
               
               
                   
                   
                   
                 farnesyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 CAAX box, alpha 
                   
                   
                   
               
               
                 215504_x_at 
                 AF131777 
                 ANKRD10 
                 Ankyrin repeat 
                 0.0117 
                 0.7025 
                 1.3 
               
               
                   
                   
                   
                 domain 10 
                   
                   
                   
               
               
                 217379_at 
                 AL121934 
                 LOC442171 
                 similar to 
                 0.0014 
                 0.1820 
                 1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L10 
                   
                   
                   
               
               
                 204454_at 
                 NM_012317 
                 LDOC1 
                 leucine zipper, 
                 0.0026 
                 0.0631 
                 1.3 
               
               
                   
                   
                   
                 down-regulated in 
                   
                   
                   
               
               
                   
                   
                   
                 cancer 1 
                   
                   
                   
               
               
                 205888_s_at 
                 AI962693 
                 JAKMIP2 
                 janus kinase and 
                 0.0374 
                 0.4240 
                 1.3 
               
               
                   
                   
                 /// 
                 microtubule 
                   
                   
                   
               
               
                   
                   
                 MYT1L 
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 2 /// myelin 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 1-like 
                   
                   
                   
               
               
                 212042_x_at 
                 BG389744 
                 RPL7 
                 ribosomal protein 
                 0.0010 
                 0.0421 
                 1.3 
               
               
                   
                   
                   
                 L7 
                   
                   
                   
               
               
                 203306_s_at 
                 NM_006416 
                 SLC35A1 
                 solute carrier 
                 0.0322 
                 0.8372 
                 1.3 
               
               
                   
                   
                   
                 family 35 (CMP- 
                   
                   
                   
               
               
                   
                   
                   
                 sialic acid 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member A1 
                   
                   
                   
               
               
                 214731_at 
                 AB037854 
                 CTTNBP2NL 
                 CTTNBP2 N- 
                 0.0329 
                 0.3513 
                 1.3 
               
               
                   
                   
                   
                 terminal like 
                   
                   
                   
               
               
                 208943_s_at 
                 U93239 
                 TLOC1 
                 translocation 
                 0.0015 
                 0.0274 
                 1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 203966_s_at 
                 NM_021003 
                 PPM1A 
                 protein 
                 0.0080 
                 0.3222 
                 1.3 
               
               
                   
                   
                   
                 phosphatase 1A 
                   
                   
                   
               
               
                   
                   
                   
                 (formerly 2C), 
                   
                   
                   
               
               
                   
                   
                   
                 magnesium- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 isoform /// protein 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatase 1A 
                   
                   
                   
               
               
                   
                   
                   
                 (formerly 2C), 
                   
                   
                   
               
               
                   
                   
                   
                 magnesium- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 isoform 
                   
                   
                   
               
               
                 206323_x_at 
                 NM_002547 
                 OPHN1 
                 oligophrenin 1 
                 0.0339 
                 0.2763 
                 1.3 
               
               
                 202372_at 
                 BF240652 
                 — 
                 Full-length cDNA 
                 0.0040 
                 0.0880 
                 1.3 
               
               
                   
                   
                   
                 clone 
                   
                   
                   
               
               
                   
                   
                   
                 CS0DC007YG11 
                   
                   
                   
               
               
                   
                   
                   
                 of Neuroblastoma 
                   
                   
                   
               
               
                   
                   
                   
                 Cot 25-normalized 
                   
                   
                   
               
               
                   
                   
                   
                 of  Homo sapiens   
                   
                   
                   
               
               
                   
                   
                   
                 (human) 
                   
                   
                   
               
               
                 204641_at 
                 NM_002497 
                 NEK2 
                 NIMA (never in 
                 0.0060 
                 0.1598 
                 1.3 
               
               
                   
                   
                   
                 mitosis gene a)- 
                   
                   
                   
               
               
                   
                   
                   
                 related kinase 2 
                   
                   
                   
               
               
                 218127_at 
                 AI804118 
                 NFYB 
                 nuclear 
                 0.0298 
                 0.1675 
                 1.3 
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 Y, beta 
                   
                   
                   
               
               
                 202629_at 
                 AV681579 
                 APPBP2 
                 amyloid beta 
                 0.0023 
                 0.4904 
                 1.3 
               
               
                   
                   
                   
                 precursor protein 
                   
                   
                   
               
               
                   
                   
                   
                 (cytoplasmic tail) 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 2 
                   
                   
                   
               
               
                 210817_s_at 
                 BC004130 
                 CALCOCO2 
                 calcium binding 
                 0.0082 
                 0.1515 
                 1.3 
               
               
                   
                   
                   
                 and coiled-coil 
                   
                   
                   
               
               
                   
                   
                   
                 domain 2 
                   
                   
                   
               
               
                 208195_at 
                 NM_003319 
                 TTN 
                 titin 
                 0.0265 
                 0.1949 
                 1.3 
               
               
                 205126_at 
                 NM_006296 
                 VRK2 
                 vaccinia related 
                 0.0033 
                 0.0365 
                 1.2 
               
               
                   
                   
                   
                 kinase 2 
                   
                   
                   
               
               
                 219356_s_at 
                 NM_016410 
                 CHMP5 
                 chromatin 
                 0.0190 
                 0.1778 
                 1.2 
               
               
                   
                   
                   
                 modifying protein 5 
                   
                   
                   
               
               
                 200686_s_at 
                 NM_004768 
                 SFRS11 
                 splicing factor, 
                 0.0064 
                 0.0719 
                 1.2 
               
               
                   
                   
                   
                 arginine/serine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 11 
                   
                   
                   
               
               
                 204630_s_at 
                 NM_004871 
                 GOSR1 
                 golgi SNAP 
                 0.0098 
                 0.3668 
                 1.2 
               
               
                   
                   
                   
                 receptor complex 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 221641_s_at 
                 AF241787 
                 ACOT9 
                 acyl-CoA 
                 0.0253 
                 0.1581 
                 1.2 
               
               
                   
                   
                   
                 thioesterase 9 
                   
                   
                   
               
               
                 217317_s_at 
                 AB002391 
                 HERC2P3 
                 hect domain and 
                 0.0403 
                 0.4707 
                 1.2 
               
               
                   
                   
                 /// 
                 RLD 2 pseudogene 
                   
                   
                   
               
               
                   
                   
                 HERC2P2 
                 3 /// hect domain 
                   
                   
                   
               
               
                   
                   
                 /// 
                 and RLD 2 
                   
                   
                   
               
               
                   
                   
                 LOC440248 
                 pseudogene 2 /// 
                   
                   
                   
               
               
                   
                   
                   
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 LOC440248 
                   
                   
                   
               
               
                 213794_s_at 
                 AI269117 
                 NGDN 
                 neuroguidin, 
                 0.0074 
                 0.1963 
                 1.2 
               
               
                   
                   
                   
                 EIF4E binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 203621_at 
                 NM_002492 
                 NDUFB5 
                 NADH 
                 0.0297 
                 0.1554 
                 1.2 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) 1 beta 
                   
                   
                   
               
               
                   
                   
                   
                 subcomplex, 5, 
                   
                   
                   
               
               
                   
                   
                   
                 16 kDa 
                   
                   
                   
               
               
                 219940_s_at 
                 NM_018386 
                 PCID2 
                 PCI domain 
                 0.0102 
                 0.3122 
                 1.2 
               
               
                   
                   
                   
                 containing 2 
                   
                   
                   
               
               
                 214715_x_at 
                 AK024789 
                 ZNF160 
                 zinc finger protein 
                 0.0117 
                 0.1338 
                 1.2 
               
               
                   
                   
                   
                 160 
                   
                   
                   
               
               
                 205452_at 
                 NM_004855 
                 PIGB 
                 phosphatidylinositol 
                 0.0061 
                 0.2509 
                 1.2 
               
               
                   
                   
                   
                 glycan anchor 
                   
                   
                   
               
               
                   
                   
                   
                 biosynthesis, class B 
                   
                   
                   
               
               
                 221064_s_at 
                 NM_023076 
                 C16orf28 
                 chromosome 16 
                 0.0198 
                 0.9418 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 28 
                   
                   
                   
               
               
                 220071_x_at 
                 NM_018097 
                 CEP27 
                 centrosomal 
                 0.0116 
                 0.1564 
                 1.2 
               
               
                   
                   
                   
                 protein 27 kDa 
                   
                   
                   
               
               
                 215588_x_at 
                 AK024958 
                 RIOK3 
                 RIO kinase 3 
                 0.0028 
                 0.4594 
                 1.2 
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 208717_at 
                 BC001669 
                 OXA1L 
                 oxidase 
                 0.0197 
                 0.7795 
                 1.2 
               
               
                   
                   
                   
                 (cytochrome c) 
                   
                   
                   
               
               
                   
                   
                   
                 assembly 1-like 
                   
                   
                   
               
               
                 203883_s_at 
                 BG249608 
                 RAB11FIP2 
                 RAB11 family 
                 0.0049 
                 0.1190 
                 1.2 
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 2 (class I) 
                   
                   
                   
               
               
                 218766_s_at 
                 NM_015836 
                 WARS2 
                 tryptophanyl tRNA 
                 0.0147 
                 0.1269 
                 1.2 
               
               
                   
                   
                   
                 synthetase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial) 
                   
                   
                   
               
               
                 221527_s_at 
                 AF196185 
                 PARD3 
                 par-3 partitioning 
                 0.0232 
                 0.1408 
                 1.2 
               
               
                   
                   
                   
                 defective 3 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( C. elegans ) 
                   
                   
                   
               
               
                 200994_at 
                 BG291787 
                 IPO7 
                 Importin 7 
                 0.0388 
                 0.6843 
                 1.2 
               
               
                 221923_s_at 
                 AA191576 
                 NPM1 
                 nucleophosmin 
                 0.0071 
                 0.0636 
                 1.2 
               
               
                   
                   
                   
                 (nucleolar 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 B23, numatrin) 
                   
                   
                   
               
               
                 201253_s_at 
                 NM_006319 
                 CDIPT 
                 CDP- 
                 0.0133 
                 0.1470 
                 1.2 
               
               
                   
                   
                   
                 diacylglycerol-- 
                   
                   
                   
               
               
                   
                   
                   
                 inositol 3- 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatidyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (phosphatidylinositol 
                   
                   
                   
               
               
                   
                   
                   
                 synthase) 
                   
                   
                   
               
               
                 213687_s_at 
                 BE968801 
                 RPL35A 
                 ribosomal protein 
                 0.0012 
                 0.0344 
                 1.2 
               
               
                   
                   
                   
                 L35a 
                   
                   
                   
               
               
                 221419_s_at 
                 NM_013307 
                 — 
                 — 
                 0.0174 
                 0.1039 
                 1.2 
               
               
                 212153_at 
                 AB007930 
                 POGZ 
                 pogo transposable 
                 0.0024 
                 0.4615 
                 1.2 
               
               
                   
                   
                   
                 element with ZNF 
                   
                   
                   
               
               
                   
                   
                   
                 domain 
                   
                   
                   
               
               
                 202021_x_at 
                 AF083441 
                 EIF1 
                 eukaryotic 
                 0.0012 
                 0.1070 
                 1.2 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 1 
                   
                   
                   
               
               
                 213896_x_at 
                 BE856549 
                 KIAA0974 
                 KIAA0974 
                 0.0118 
                 0.1469 
                 1.2 
               
               
                 200823_x_at 
                 NM_000992 
                 RPL29 
                 ribosomal protein 
                 0.0061 
                 0.2552 
                 1.2 
               
               
                   
                   
                   
                 L29 
                   
                   
                   
               
               
                 215179_x_at 
                 AK023843 
                 PGF 
                 Placental growth 
                 0.0085 
                 0.1642 
                 1.2 
               
               
                   
                   
                   
                 factor, vascular 
                   
                   
                   
               
               
                   
                   
                   
                 endothelial growth 
                   
                   
                   
               
               
                   
                   
                   
                 factor-related 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 203351_s_at 
                 AF047598 
                 ORC4L 
                 origin recognition 
                 0.0199 
                 0.3619 
                 1.2 
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 4-like (yeast) 
                   
                   
                   
               
               
                 200905_x_at 
                 NM_005516 
                 HLA-E 
                 major 
                 0.0053 
                 0.1334 
                 1.2 
               
               
                   
                   
                   
                 histocompatibility 
                   
                   
                   
               
               
                   
                   
                   
                 complex, class I, E 
                   
                   
                   
               
               
                 219119_at 
                 NM_016200 
                 LSM8 
                 LSM8 homolog, 
                 0.0447 
                 0.2301 
                 1.2 
               
               
                   
                   
                   
                 U6 small nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 RNA associated ( S. cerevisiae ) 
                   
                   
                   
               
               
                 214305_s_at 
                 AW003030 
                 SF3B1 
                 splicing factor 3b, 
                 0.0061 
                 0.0197 
                 1.2 
               
               
                   
                   
                   
                 subunit 1, 155 kDa 
                   
                   
                   
               
               
                 200099_s_at 
                 AL356115 
                 RPS3A /// 
                 ribosomal protein 
                 0.0040 
                 0.0558 
                 1.2 
               
               
                   
                   
                 LOC439992 
                 S3A /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S3A /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S3a /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S3a 
                   
                   
                   
               
               
                 218007_s_at 
                 NM_015920 
                 RPS27L 
                 ribosomal protein 
                 0.0046 
                 0.0971 
                 1.2 
               
               
                   
                   
                   
                 S27-like 
                   
                   
                   
               
               
                 203445_s_at 
                 NM_005730 
                 CTDSP2 
                 CTD (carboxy- 
                 0.0057 
                 0.1941 
                 1.2 
               
               
                   
                   
                   
                 terminal domain, 
                   
                   
                   
               
               
                   
                   
                   
                 RNA polymerase 
                   
                   
                   
               
               
                   
                   
                   
                 II, polypeptide A) 
                   
                   
                   
               
               
                   
                   
                   
                 small phosphatase 2 
                   
                   
                   
               
               
                 220796_x_at 
                 NM_024881 
                 SLC35E1 
                 solute carrier 
                 0.0136 
                 0.2093 
                 1.2 
               
               
                   
                   
                   
                 family 35, member 
                   
                   
                   
               
               
                   
                   
                   
                 E1 
                   
                   
                   
               
               
                 203261_at 
                 NM_006571 
                 DCTN6 
                 dynactin 6 
                 0.0322 
                 0.2746 
                 1.2 
               
               
                 204362_at 
                 NM_003930 
                 SKAP2 
                 src kinase 
                 0.0267 
                 0.5442 
                 1.2 
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoprotein 2 
                   
                   
                   
               
               
                 200858_s_at 
                 NM_001012 
                 RPS8 
                 ribosomal protein 
                 0.0024 
                 0.0843 
                 1.2 
               
               
                   
                   
                   
                 S8 
                   
                   
                   
               
               
                 212229_s_at 
                 AK001699 
                 FBXO21 
                 F-box protein 21 
                 0.0336 
                 0.1148 
                 1.2 
               
               
                 216187_x_at 
                 AF222691 
                 KNS2 
                 Kinesin 2 
                 0.0161 
                 0.8431 
                 1.2 
               
               
                 201483_s_at 
                 BC002802 
                 SUPT4H1 
                 suppressor of Ty 4 
                 0.0079 
                 0.9595 
                 1.2 
               
               
                   
                   
                   
                 homolog 1 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 208855_s_at 
                 AF083420 
                 STK24 
                 serine/threonine 
                 0.0136 
                 0.0721 
                 1.2 
               
               
                   
                   
                   
                 kinase 24 (STE20 
                   
                   
                   
               
               
                   
                   
                   
                 homolog, yeast) 
                   
                   
                   
               
               
                 207180_s_at 
                 NM_006410 
                 HTATIP2 
                 HIV-1 Tat 
                 0.0359 
                 0.8053 
                 1.2 
               
               
                   
                   
                   
                 interactive protein 
                   
                   
                   
               
               
                   
                   
                   
                 2, 30 kDa 
                   
                   
                   
               
               
                 219590_x_at 
                 NM_015958 
                 DPH5 
                 DPH5 homolog ( S. cerevisiae ) 
                 0.0029 
                 0.1068 
                 1.2 
               
               
                 218630_at 
                 NM_017777 
                 MKS1 
                 Meckel syndrome, 
                 0.0224 
                 0.5271 
                 1.2 
               
               
                   
                   
                   
                 type 1 
                   
                   
                   
               
               
                 202279_at 
                 NM_004894 
                 C14orf2 
                 chromosome 14 
                 0.0155 
                 0.0721 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 2 
                   
                   
                   
               
               
                 217122_s_at 
                 AL031282 
                 SLC35E2 
                 solute carrier 
                 0.0178 
                 0.3398 
                 1.2 
               
               
                   
                   
                 /// 
                 family 35, member 
                   
                   
                   
               
               
                   
                   
                 LOC728661 
                 E2 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 solute carrier 
                   
                   
                   
               
               
                   
                   
                   
                 family 35, member 
                   
                   
                   
               
               
                   
                   
                   
                 E2 
                   
                   
                   
               
               
                 208933_s_at 
                 AI659005 
                 — 
                 — 
                 0.0027 
                 0.0803 
                 1.2 
               
               
                 205327_s_at 
                 NM_001616 
                 ACVR2A 
                 activin A receptor, 
                 0.0357 
                 0.5733 
                 1.2 
               
               
                   
                   
                   
                 type IIA 
                   
                   
                   
               
               
                 203448_s_at 
                 AI347136 
                 TERF1 
                 telomeric repeat 
                 0.0112 
                 0.0284 
                 1.2 
               
               
                   
                   
                   
                 binding factor 
                   
                   
                   
               
               
                   
                   
                   
                 (NIMA- 
                   
                   
                   
               
               
                   
                   
                   
                 interacting) 1 
                   
                   
                   
               
               
                 218250_s_at 
                 NM_013354 
                 CNOT7 
                 CCR4-NOT 
                 0.0049 
                 0.0564 
                 1.2 
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 7 
                   
                   
                   
               
               
                 214097_at 
                 AW024383 
                 RPS21 
                 ribosomal protein 
                 0.0345 
                 0.3691 
                 1.2 
               
               
                   
                   
                   
                 S21 
                   
                   
                   
               
               
                 214802_at 
                 AK022397 
                 EXOC7 
                 exocyst complex 
                 0.0299 
                 0.4976 
                 1.2 
               
               
                   
                   
                   
                 component 7 
                   
                   
                   
               
               
                 202970_at 
                 AI192838 
                 — 
                 MRNA; cDNA 
                 0.0404 
                 0.1580 
                 1.2 
               
               
                   
                   
                   
                 DKFZp667B0924 
                   
                   
                   
               
               
                   
                   
                   
                 (from clone 
                   
                   
                   
               
               
                   
                   
                   
                 DKFZp667B0924) 
                   
                   
                   
               
               
                 202317_s_at 
                 NM_006048 
                 UBE4B 
                 ubiquitination 
                 0.0069 
                 0.5881 
                 1.2 
               
               
                   
                   
                   
                 factor E4B (UFD2 
                   
                   
                   
               
               
                   
                   
                   
                 homolog, yeast) 
                   
                   
                   
               
               
                 209329_x_at 
                 BC000587 
                 HIGD2A 
                 HIG1 domain 
                 0.0186 
                 0.5037 
                 1.2 
               
               
                   
                   
                   
                 family, member 2A 
                   
                   
                   
               
               
                 214686_at 
                 AA868898 
                 ZNF266 
                 zinc finger protein 
                 0.0199 
                 0.6239 
                 1.2 
               
               
                   
                   
                   
                 266 
                   
                   
                   
               
               
                 214143_x_at 
                 AI560573 
                 RPL24 /// 
                 ribosomal protein 
                 0.0022 
                 0.0284 
                 1.2 
               
               
                   
                   
                 ACSM3 
                 L24 /// acyl-CoA 
                   
                   
                   
               
               
                   
                   
                 /// 
                 synthetase 
                   
                   
                   
               
               
                   
                   
                 SLC36A2 
                 medium-chain 
                   
                   
                   
               
               
                   
                   
                   
                 family member 3 
                   
                   
                   
               
               
                   
                   
                   
                 /// solute carrier 
                   
                   
                   
               
               
                   
                   
                   
                 family 36 
                   
                   
                   
               
               
                   
                   
                   
                 (proton/amino acid 
                   
                   
                   
               
               
                   
                   
                   
                 symporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 2 
                   
                   
                   
               
               
                 203316_s_at 
                 NM_003094 
                 SNRPE 
                 small nuclear 
                 0.0241 
                 0.1629 
                 1.2 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide E 
                   
                   
                   
               
               
                 221934_s_at 
                 BF941492 
                 DALRD3 
                 DALR anticodon 
                 0.0322 
                 0.8698 
                 1.2 
               
               
                   
                   
                   
                 binding domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 221540_x_at 
                 AF078847 
                 GTF2H2 
                 general 
                 0.0289 
                 0.1892 
                 1.2 
               
               
                   
                   
                 /// 
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                 DKFZP686M0199 
                 IIH, polypeptide 2, 
                   
                   
                   
               
               
                   
                   
                 /// 
                 44 kDa /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC653866 
                 TFIIH basal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                 LOC728340 
                 complex p44 
                   
                   
                   
               
               
                   
                   
                 /// 
                 subunit (Basic 
                   
                   
                   
               
               
                   
                   
                 LOC730394 
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 2 44 kDa subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (BTF2-p44) 
                   
                   
                   
               
               
                   
                   
                   
                 (General 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIH polypeptide 2) 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to TFIIH 
                   
                   
                   
               
               
                   
                   
                   
                 basal transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factor complex p44 
                   
                   
                   
               
               
                   
                   
                   
                 subunit (Basic 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 2 44 kDa subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (BTF2-p44) 
                   
                   
                   
               
               
                   
                   
                   
                 (General 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIH polypeptide 2) 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to TFIIH 
                   
                   
                   
               
               
                   
                   
                   
                 basal transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factor complex p44 
                   
                   
                   
               
               
                   
                   
                   
                 subunit (Basic 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 2 44 kDa subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (BTF2-p44) 
                   
                   
                   
               
               
                   
                   
                   
                 (General 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIH polypeptide 2) 
                   
                   
                   
               
               
                   
                   
                   
                 /// region 
                   
                   
                   
               
               
                   
                   
                   
                 containing general 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIH, polypeptide 2, 
                   
                   
                   
               
               
                   
                   
                   
                 44 kDa; similar to 
                   
                   
                   
               
               
                   
                   
                   
                 TFIIH basal 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 complex p44 
                   
                   
                   
               
               
                   
                   
                   
                 subunit (Basic 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 2 44 kDa subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (BTF2-p44) 
                   
                   
                   
               
               
                   
                   
                   
                 (General 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIH polypeptide 2) 
                   
                   
                   
               
               
                 202054_s_at 
                 NM_000382 
                 ALDH3A2 
                 aldehyde 
                 0.0264 
                 0.2941 
                 1.2 
               
               
                   
                   
                   
                 dehydrogenase 3 
                   
                   
                   
               
               
                   
                   
                   
                 family, member A2 
                   
                   
                   
               
               
                 35436_at 
                 L06147 
                 GOLGA2 
                 golgi autoantigen, 
                 0.0143 
                 0.2075 
                 1.2 
               
               
                   
                   
                   
                 golgin subfamily a, 2 
                   
                   
                   
               
               
                 218988_at 
                 NM_018656 
                 SLC35E3 
                 solute carrier 
                 0.0332 
                 0.4575 
                 1.2 
               
               
                   
                   
                   
                 family 35, member 
                   
                   
                   
               
               
                   
                   
                   
                 E3 
                   
                   
                   
               
               
                 212632_at 
                 N32035 
                 STX7 
                 Syntaxin 7 
                 0.0264 
                 0.4759 
                 1.2 
               
               
                 209472_at 
                 BC000819 
                 RP11- 
                 kynurenine 
                 0.0347 
                 0.1281 
                 1.2 
               
               
                   
                   
                 82K18.3 
                 aminotransferase 
                   
                   
                   
               
               
                   
                   
                   
                 III 
                   
                   
                   
               
               
                 204020_at 
                 BF739943 
                 PURA 
                 purine-rich element 
                 0.0149 
                 0.0874 
                 1.2 
               
               
                   
                   
                   
                 binding protein A 
                   
                   
                   
               
               
                 208113_x_at 
                 NM_030979 
                 PABPC3 
                 poly(A) binding 
                 0.0330 
                 0.2927 
                 1.2 
               
               
                   
                   
                   
                 protein, 
                   
                   
                   
               
               
                   
                   
                   
                 cytoplasmic 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 poly(A) binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein, 
                   
                   
                   
               
               
                   
                   
                   
                 cytoplasmic 3 
                   
                   
                   
               
               
                 214394_x_at 
                 AI613383 
                 EEF1D /// 
                 eukaryotic 
                 0.0013 
                 0.0326 
                 1.2 
               
               
                   
                   
                 LOC126037 
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 elongation factor 1 
                   
                   
                   
               
               
                   
                   
                   
                 delta (guanine 
                   
                   
                   
               
               
                   
                   
                   
                 nucleotide 
                   
                   
                   
               
               
                   
                   
                   
                 exchange protein) 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Elongation factor 
                   
                   
                   
               
               
                   
                   
                   
                 1-delta (EF-1- 
                   
                   
                   
               
               
                   
                   
                   
                 delta) (Antigen 
                   
                   
                   
               
               
                   
                   
                   
                 NY-CO-4) 
                   
                   
                   
               
               
                 213292_s_at 
                 AA908770 
                 SNX13 
                 sorting nexin 13 
                 0.0283 
                 0.1715 
                 1.2 
               
               
                 220046_s_at 
                 NM_020307 
                 CCNL1 
                 cyclin L1 
                 0.0054 
                 0.1498 
                 1.2 
               
               
                 202379_s_at 
                 AI361805 
                 NKTR 
                 natural killer-tumor 
                 0.0226 
                 0.0758 
                 1.2 
               
               
                   
                   
                   
                 recognition 
                   
                   
                   
               
               
                   
                   
                   
                 sequence 
                   
                   
                   
               
               
                 221787_at 
                 BF431618 
                 C6orf120 
                 chromosome 6 
                 0.0087 
                 0.0877 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 120 
                   
                   
                   
               
               
                 210296_s_at 
                 BC005375 
                 PXMP3 
                 peroxisomal 
                 0.0152 
                 0.5465 
                 1.2 
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                   
                   
                   
                 3, 35 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (Zellweger 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome) 
                   
                   
                   
               
               
                 209678_s_at 
                 L18964 
                 PRKCI 
                 protein kinase C, 
                 0.0298 
                 0.0441 
                 1.2 
               
               
                   
                   
                   
                 iota 
                   
                   
                   
               
               
                 219926_at 
                 NM_022361 
                 POPDC3 
                 popeye domain 
                 0.0062 
                 0.0307 
                 1.2 
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 212474_at 
                 D87682 
                 KIAA0241 
                 KIAA0241 
                 0.0221 
                 0.3172 
                 1.2 
               
               
                 217820_s_at 
                 NM_018212 
                 ENAH 
                 enabled homolog 
                 0.0366 
                 0.1120 
                 1.2 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 212447_at 
                 AF161402 
                 KBTBD2 
                 kelch repeat and 
                 0.0089 
                 0.4481 
                 1.2 
               
               
                   
                   
                   
                 BTB (POZ) 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 212368_at 
                 AA972711 
                 ZNF292 
                 zinc finger protein 
                 0.0176 
                 0.0861 
                 1.2 
               
               
                   
                   
                   
                 292 
                   
                   
                   
               
               
                 202829_s_at 
                 NM_005638 
                 SYBL1 
                 synaptobrevin-like 1 
                 0.0160 
                 0.1131 
                 1.2 
               
               
                 216310_at 
                 AK024376 
                 TAOK1 
                 TAO kinase 1 
                 0.0075 
                 0.5594 
                 1.2 
               
               
                 211297_s_at 
                 L20320 
                 CDK7 
                 cyclin-dependent 
                 0.0359 
                 0.0916 
                 1.2 
               
               
                   
                   
                   
                 kinase 7 (MO15 
                   
                   
                   
               
               
                   
                   
                   
                 homolog,  Xenopus   
                   
                   
                   
               
               
                   
                   
                   
                   laevis , cdk- 
                   
                   
                   
               
               
                   
                   
                   
                 activating kinase) 
                   
                   
                   
               
               
                 210686_x_at 
                 BC001407 
                 SLC25A16 
                 solute carrier 
                 0.0079 
                 0.2001 
                 1.2 
               
               
                   
                   
                   
                 family 25 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 carrier; Graves 
                   
                   
                   
               
               
                   
                   
                   
                 disease 
                   
                   
                   
               
               
                   
                   
                   
                 autoantigen), 
                   
                   
                   
               
               
                   
                   
                   
                 member 16 
                   
                   
                   
               
               
                 201032_at 
                 NM_006698 
                 BLCAP 
                 bladder cancer 
                 0.0011 
                 0.1159 
                 1.2 
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                 218467_at 
                 NM_020232 
                 TNFSF5IP1 
                 tumor necrosis 
                 0.0055 
                 0.1200 
                 1.2 
               
               
                   
                   
                   
                 factor superfamily, 
                   
                   
                   
               
               
                   
                   
                   
                 member 5-induced 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 205526_s_at 
                 NM_007044 
                 KATNA1 
                 katanin p60 
                 0.0142 
                 0.0800 
                 1.2 
               
               
                   
                   
                   
                 (ATPase- 
                   
                   
                   
               
               
                   
                   
                   
                 containing) subunit 
                   
                   
                   
               
               
                   
                   
                   
                 A 1 
                   
                   
                   
               
               
                 208066_s_at 
                 NM_001514 
                 GTF2B 
                 general 
                 0.0333 
                 0.3117 
                 1.2 
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIB /// general 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 
                   
                   
                   
               
               
                   
                   
                   
                 IIB 
                   
                   
                   
               
               
                 209069_s_at 
                 BC001124 
                 H3F3B 
                 H3 histone, family 
                 0.0174 
                 0.0958 
                 1.2 
               
               
                   
                   
                   
                 3B (H3.3B) 
                   
                   
                   
               
               
                 210908_s_at 
                 AB055804 
                 PFDN5 
                 prefoldin subunit 5 
                 0.0045 
                 0.0424 
                 1.2 
               
               
                 218098_at 
                 AL121903 
                 — 
                 — 
                 0.0396 
                 0.3857 
                 1.2 
               
               
                 208904_s_at 
                 BC000354 
                 RPS28 /// 
                 ribosomal protein 
                 0.0019 
                 0.1381 
                 1.2 
               
               
                   
                   
                 LOC645899 
                 S28 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                 LOC646195 
                 protein S28 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 40S 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S28 
                   
                   
                   
               
               
                 201371_s_at 
                 AF062537 
                 CUL3 
                 cullin 3 
                 0.0109 
                 0.0933 
                 1.2 
               
               
                 219703_at 
                 NM_018365 
                 MNS1 
                 meiosis-specific 
                 0.0184 
                 0.0703 
                 1.2 
               
               
                   
                   
                   
                 nuclear structural 1 
                   
                   
                   
               
               
                 205788_s_at 
                 NM_014827 
                 ZC3H11A 
                 zinc finger CCCH- 
                 0.0255 
                 0.7984 
                 1.2 
               
               
                   
                   
                   
                 type containing 
                   
                   
                   
               
               
                   
                   
                   
                 11A 
                   
                   
                   
               
               
                 221829_s_at 
                 AI307759 
                 TNPO1 
                 transportin 1 
                 0.0043 
                 0.0185 
                 1.2 
               
               
                 212600_s_at 
                 AV727381 
                 UQCRC2 
                 ubiquinol- 
                 0.0050 
                 0.0383 
                 1.2 
               
               
                   
                   
                   
                 cytochrome c 
                   
                   
                   
               
               
                   
                   
                   
                 reductase core 
                   
                   
                   
               
               
                   
                   
                   
                 protein II 
                   
                   
                   
               
               
                 200034_s_at 
                 NM_000970 
                 RPL6 
                 ribosomal protein 
                 0.0060 
                 0.2152 
                 1.2 
               
               
                   
                   
                   
                 L6 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L6 
                   
                   
                   
               
               
                 200036_s_at 
                 NM_007104 
                 RPL10A 
                 ribosomal protein 
                 0.0020 
                 0.0971 
                 1.2 
               
               
                   
                   
                   
                 L10a /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L10a 
                   
                   
                   
               
               
                 216858_x_at 
                 AL080112 
                 — 
                 — 
                 0.0298 
                 0.1388 
                 1.2 
               
               
                 203034_s_at 
                 NM_000990 
                 RPL27A 
                 ribosomal protein 
                 0.0010 
                 0.0274 
                 1.2 
               
               
                   
                   
                 /// 
                 L27a /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC389435 
                 60S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L27a 
                   
                   
                   
               
               
                 200726_at 
                 NM_002710 
                 PPP1CC 
                 protein 
                 0.0326 
                 0.5063 
                 1.2 
               
               
                   
                   
                   
                 phosphatase 1, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit, 
                   
                   
                   
               
               
                   
                   
                   
                 gamma isoform 
                   
                   
                   
               
               
                 217941_s_at 
                 NM_018695 
                 ERBB2IP 
                 erbb2 interacting 
                 0.0195 
                 0.6001 
                 1.2 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 200018_at 
                 NM_001017 
                 RPS13 
                 ribosomal protein 
                 0.0006 
                 0.0252 
                 1.2 
               
               
                   
                   
                   
                 S13 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S13 
                   
                   
                   
               
               
                 200705_s_at 
                 NM_001959 
                 EEF1B2 
                 eukaryotic 
                 0.0007 
                 0.0157 
                 1.2 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 elongation factor 1 
                   
                   
                   
               
               
                   
                   
                   
                 beta 2 
                   
                   
                   
               
               
                 205042_at 
                 NM_005476 
                 GNE 
                 glucosamine 
                 0.0294 
                 0.2075 
                 1.2 
               
               
                   
                   
                   
                 (UDP-N-acetyl)-2- 
                   
                   
                   
               
               
                   
                   
                   
                 epimerase/N- 
                   
                   
                   
               
               
                   
                   
                   
                 acetylmannosamine 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 
                   
                   
                   
               
               
                 218654_s_at 
                 NM_016071 
                 MRPS33 
                 mitochondrial 
                 0.0011 
                 0.0282 
                 1.2 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S33 
                   
                   
                   
               
               
                 212345_s_at 
                 BE675139 
                 CREB3L2 
                 cAMP responsive 
                 0.0168 
                 0.1160 
                 1.2 
               
               
                   
                   
                   
                 element binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 3-like 2 
                   
                   
                   
               
               
                 207700_s_at 
                 NM_006534 
                 NCOA3 
                 nuclear receptor 
                 0.0380 
                 0.0932 
                 1.2 
               
               
                   
                   
                   
                 coactivator 3 
                   
                   
                   
               
               
                 202378_s_at 
                 NM_017526 
                 LEPROT 
                 leptin receptor 
                 0.0092 
                 0.0747 
                 1.2 
               
               
                   
                   
                   
                 overlapping 
                   
                   
                   
               
               
                   
                   
                   
                 transcript 
                   
                   
                   
               
               
                 215823_x_at 
                 U64661 
                 PABPC3 
                 poly(A) binding 
                 0.0081 
                 0.0893 
                 1.2 
               
               
                   
                   
                 /// 
                 protein, 
                   
                   
                   
               
               
                   
                   
                 PABPC1 
                 cytoplasmic 3 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 poly(A) binding 
                   
                   
                   
               
               
                   
                   
                 LOC341315 
                 protein, 
                   
                   
                   
               
               
                   
                   
                 /// 
                 cytoplasmic 1 /// 
                   
                   
                   
               
               
                   
                   
                 LOC652607 
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 LOC341315 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Polyadenylate- 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Poly(A)-binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1) (PABP 
                   
                   
                   
               
               
                   
                   
                   
                 1) 
                   
                   
                   
               
               
                 205176_s_at 
                 NM_014288 
                 ITGB3BP 
                 integrin beta 3 
                 0.0354 
                 0.3312 
                 1.2 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 (beta3-endonexin) 
                   
                   
                   
               
               
                 217491_x_at 
                 AF042165 
                 COX7C 
                 cytochrome c 
                 0.0007 
                 0.0452 
                 1.2 
               
               
                   
                   
                   
                 oxidase subunit 
                   
                   
                   
               
               
                   
                   
                   
                 VIIc 
                   
                   
                   
               
               
                 209007_s_at 
                 AF267856 
                 C1orf63 
                 chromosome 1 
                 0.0468 
                 0.9308 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 63 
                   
                   
                   
               
               
                 208993_s_at 
                 AW340788 
                 PPIG 
                 peptidylprolyl 
                 0.0404 
                 0.0424 
                 1.2 
               
               
                   
                   
                   
                 isomerase G 
                   
                   
                   
               
               
                   
                   
                   
                 (cyclophilin G) 
                   
                   
                   
               
               
                 212440_at 
                 X76302 
                 RY1 
                 putative nucleic 
                 0.0038 
                 0.0285 
                 1.2 
               
               
                   
                   
                   
                 acid binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein RY-1 
                   
                   
                   
               
               
                 213179_at 
                 BG289914 
                 — 
                 — 
                 0.0149 
                 0.7695 
                 1.2 
               
               
                 200092_s_at 
                 BF216701 
                 RPL37 
                 ribosomal protein 
                 0.0007 
                 0.0197 
                 1.2 
               
               
                   
                   
                   
                 L37 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L37 
                   
                   
                   
               
               
                 208695_s_at 
                 BC001019 
                 RPL39 
                 ribosomal protein 
                 0.0035 
                 0.0984 
                 1.2 
               
               
                   
                   
                   
                 L39 
                   
                   
                   
               
               
                 202265_at 
                 NM_005180 
                 BMI1 
                 B lymphoma Mo- 
                 0.0159 
                 0.0499 
                 1.2 
               
               
                   
                   
                   
                 MLV insertion 
                   
                   
                   
               
               
                   
                   
                   
                 region (mouse) 
                   
                   
                   
               
               
                 208610_s_at 
                 AI655799 
                 SRRM2 
                 serine/arginine 
                 0.0301 
                 0.0441 
                 1.2 
               
               
                   
                   
                   
                 repetitive matrix 2 
                   
                   
                   
               
               
                 218146_at 
                 NM_018446 
                 GLT8D1 
                 glycosyltransferase 
                 0.0261 
                 0.3313 
                 1.2 
               
               
                   
                   
                   
                 8 domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 215424_s_at 
                 AV689564 
                 SNW1 
                 SNW domain 
                 0.0168 
                 0.2988 
                 1.2 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 206089_at 
                 NM_006157 
                 NELL1 
                 NEL-like 1 
                 0.0451 
                 0.1134 
                 1.2 
               
               
                   
                   
                   
                 (chicken) 
                   
                   
                   
               
               
                 201041_s_at 
                 NM_004417 
                 DUSP1 
                 dual specificity 
                 0.0237 
                 0.9234 
                 1.2 
               
               
                   
                   
                   
                 phosphatase 1 
                   
                   
                   
               
               
                 204576_s_at 
                 AA207013 
                 CLUAP1 
                 clusterin associated 
                 0.0329 
                 0.9377 
                 1.2 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 202710_at 
                 BC000899 
                 BET1 
                 BET1 homolog ( S. cerevisiae ) 
                 0.0267 
                 0.2967 
                 1.2 
               
               
                 201653_at 
                 NM_005776 
                 CNIH 
                 cornichon homolog 
                 0.0011 
                 0.0185 
                 1.2 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 203858_s_at 
                 NM_001303 
                 COX10 
                 COX10 homolog, 
                 0.0030 
                 0.0383 
                 1.2 
               
               
                   
                   
                   
                 cytochrome c 
                   
                   
                   
               
               
                   
                   
                   
                 oxidase assembly 
                   
                   
                   
               
               
                   
                   
                   
                 protein, heme A: 
                   
                   
                   
               
               
                   
                   
                   
                 farnesyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 213049_at 
                 BG436400 
                 GARNL1 
                 GTPase activating 
                 0.0416 
                 0.1940 
                 1.2 
               
               
                   
                   
                   
                 Rap/RanGAP 
                   
                   
                   
               
               
                   
                   
                   
                 domain-like 1 
                   
                   
                   
               
               
                 217975_at 
                 NM_016303 
                 WBP5 
                 WW domain 
                 0.0129 
                 0.0467 
                 1.2 
               
               
                   
                   
                   
                 binding protein 5 
                   
                   
                   
               
               
                 209760_at 
                 AL136932 
                 KIAA0922 
                 KIAA0922 
                 0.0378 
                 0.7343 
                 1.2 
               
               
                 217256_x_at 
                 Z98950 
                 LOC641903 
                 similar to large 
                 0.0029 
                 0.2079 
                 1.2 
               
               
                   
                   
                 /// 
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                 LOC643505 
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 similar to large 
                   
                   
                   
               
               
                   
                   
                 LOC646175 
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                 LOC649299 
                 similar to large 
                   
                   
                   
               
               
                   
                   
                 /// 
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                 LOC651209 
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 similar to large 
                   
                   
                   
               
               
                   
                   
                 LOC728202 
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                 LOC732102 
                 similar to large 
                   
                   
                   
               
               
                   
                   
                   
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to large 
                   
                   
                   
               
               
                   
                   
                   
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L36a /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to large 
                   
                   
                   
               
               
                   
                   
                   
                 subunit ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L36a 
                   
                   
                   
               
               
                 200847_s_at 
                 NM_016127 
                 TMEM66 
                 transmembrane 
                 0.0402 
                 0.3313 
                 1.2 
               
               
                   
                   
                   
                 protein 66 
                   
                   
                   
               
               
                 203011_at 
                 NM_005536 
                 IMPA1 
                 inositol(myo)-1(or 
                 0.0121 
                 0.0452 
                 1.2 
               
               
                   
                   
                   
                 4)- 
                   
                   
                   
               
               
                   
                   
                   
                 monophosphatase 1 
                   
                   
                   
               
               
                 209447_at 
                 AF043290 
                 SYNE1 
                 spectrin repeat 
                 0.0367 
                 0.1023 
                 1.2 
               
               
                   
                   
                   
                 containing, nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 envelope 1 
                   
                   
                   
               
               
                 217846_at 
                 NM_005051 
                 QARS 
                 glutaminyl-tRNA 
                 0.0008 
                 0.0841 
                 1.2 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 218341_at 
                 NM_024664 
                 PPCS 
                 phosphopantotheno 
                 0.0369 
                 0.0576 
                 1.2 
               
               
                   
                   
                   
                 ylcysteine 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 219762_s_at 
                 NM_015414 
                 RPL36 
                 ribosomal protein 
                 0.0060 
                 0.1247 
                 1.2 
               
               
                   
                   
                   
                 L36 
                   
                   
                   
               
               
                 215907_at 
                 AK027193 
                 BACH2 
                 BTB and CNC 
                 0.0197 
                 0.2184 
                 1.2 
               
               
                   
                   
                   
                 homology 1, basic 
                   
                   
                   
               
               
                   
                   
                   
                 leucine zipper 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 2 
                   
                   
                   
               
               
                 202336_s_at 
                 NM_000919 
                 PAM 
                 peptidylglycine 
                 0.0451 
                 0.2016 
                 1.2 
               
               
                   
                   
                   
                 alpha-amidating 
                   
                   
                   
               
               
                   
                   
                   
                 monooxygenase 
                   
                   
                   
               
               
                 219220_x_at 
                 NM_020191 
                 MRPS22 
                 mitochondrial 
                 0.0016 
                 0.0383 
                 1.2 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S22 
                   
                   
                   
               
               
                 203292_s_at 
                 NM_021729 
                 VPS11 
                 vacuolar protein 
                 0.0249 
                 0.4069 
                 1.2 
               
               
                   
                   
                   
                 sorting 11 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 201290_at 
                 NM_014300 
                 SEC11A 
                 SEC11 homolog A 
                 0.0025 
                 0.0417 
                 1.2 
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 219711_at 
                 NM_017652 
                 ZNF586 
                 zinc finger protein 
                 0.0476 
                 0.8054 
                 1.2 
               
               
                   
                   
                   
                 586 
                   
                   
                   
               
               
                 219030_at 
                 NM_016058 
                 TPRKB 
                 TP53RK binding 
                 0.0354 
                 0.1017 
                 1.2 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 210139_s_at 
                 L03203 
                 PMP22 
                 peripheral myelin 
                 0.0029 
                 0.4411 
                 1.2 
               
               
                   
                   
                   
                 protein 22 
                   
                   
                   
               
               
                 218991_at 
                 NM_022070 
                 ABC1 
                 amplified in breast 
                 0.0406 
                 0.4662 
                 1.2 
               
               
                   
                   
                   
                 cancer 1 
                   
                   
                   
               
               
                 219563_at 
                 NM_024633 
                 C14orf139 
                 chromosome 14 
                 0.0212 
                 0.4167 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 139 
                   
                   
                   
               
               
                 216960_s_at 
                 AL049646 
                 ZNF133 
                 zinc finger protein 
                 0.0140 
                 0.0798 
                 1.2 
               
               
                   
                   
                   
                 133 
                   
                   
                   
               
               
                 216505_x_at 
                 AL118502 
                 RPS10 /// 
                 ribosomal protein 
                 0.0045 
                 0.0853 
                 1.2 
               
               
                   
                   
                 LOC133569 
                 S10 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 RPS10P3 
                 S10 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein S10 
                   
                   
                   
               
               
                   
                   
                 LOC649303 
                 pseudogene 3 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 similar to 
                   
                   
                   
               
               
                   
                   
                 LOC654029 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 S10 /// similar to 
                   
                   
                   
               
               
                   
                   
                 LOC728791 
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protein S10 /// 
                   
                   
                   
               
               
                   
                   
                 LOC730965 
                 similar to 40S 
                   
                   
                   
               
               
                   
                   
                 /// 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                 LOC732348 
                 S10 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S10 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S10 
                   
                   
                   
               
               
                 221959_at 
                 BE672313 
                 C8orf72 
                 chromosome 8 
                 0.0176 
                 0.3838 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 72 
                   
                   
                   
               
               
                 216499_at 
                 AL137590 
                 — 
                 MRNA; cDNA 
                 0.0238 
                 0.4595 
                 1.2 
               
               
                   
                   
                   
                 DKFZp434K0610 
                   
                   
                   
               
               
                   
                   
                   
                 (from clone 
                   
                   
                   
               
               
                   
                   
                   
                 DKFZp434K0610) 
                   
                   
                   
               
               
                 204274_at 
                 AA812215 
                 EBAG9 
                 estrogen receptor 
                 0.0258 
                 0.1645 
                 1.2 
               
               
                   
                   
                   
                 binding site 
                   
                   
                   
               
               
                   
                   
                   
                 associated, antigen, 9 
                   
                   
                   
               
               
                 203098_at 
                 AL050164 
                 CDYL 
                 chromodomain 
                 0.0029 
                 0.1514 
                 1.2 
               
               
                   
                   
                   
                 protein, Y-like 
                   
                   
                   
               
               
                 221868_at 
                 AB032981 
                 KIAA1155 
                 KIAA1155 protein 
                 0.0078 
                 0.3685 
                 1.2 
               
               
                 201606_s_at 
                 BE796924 
                 PWP1 
                 PWP1 homolog ( S. cerevisiae ) 
                 0.0206 
                 0.0351 
                 1.2 
               
               
                 219740_at 
                 NM_024749 
                 VASH2 
                 vasohibin 2 
                 0.0467 
                 0.0197 
                 1.2 
               
               
                 209510_at 
                 AF064801 
                 RNF139 
                 ring finger protein 
                 0.0064 
                 0.0383 
                 1.2 
               
               
                   
                   
                   
                 139 
                   
                   
                   
               
               
                 32259_at 
                 AB002386 
                 EZH1 
                 enhancer of zeste 
                 0.0294 
                 0.6894 
                 1.2 
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 203180_at 
                 NM_000693 
                 ALDH1A3 
                 aldehyde 
                 0.0234 
                 0.0537 
                 1.2 
               
               
                   
                   
                   
                 dehydrogenase 1 
                   
                   
                   
               
               
                   
                   
                   
                 family, member A3 
                   
                   
                   
               
               
                 215582_x_at 
                 AK022303 
                 MCM3AP 
                 MCM3 
                 0.0261 
                 0.6795 
                 1.2 
               
               
                   
                   
                   
                 minichromosome 
                   
                   
                   
               
               
                   
                   
                   
                 maintenance 
                   
                   
                   
               
               
                   
                   
                   
                 deficient 3 ( S. cerevisiae ) 
                   
                   
                   
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                 202920_at 
                 BF726212 
                 ANK2 
                 ankyrin 2, neuronal 
                 0.0055 
                 0.0418 
                 1.2 
               
               
                 221423_s_at 
                 NM_030799 
                 YIPF5 
                 Yip1 domain 
                 0.0284 
                 0.2018 
                 1.2 
               
               
                   
                   
                   
                 family, member 5 
                   
                   
                   
               
               
                   
                   
                   
                 /// Yip1 domain 
                   
                   
                   
               
               
                   
                   
                   
                 family, member 5 
                   
                   
                   
               
               
                 211935_at 
                 D31885 
                 ARL6IP1 
                 ADP-ribosylation 
                 0.0025 
                 0.1564 
                 1.2 
               
               
                   
                   
                   
                 factor-like 6 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 1 
                   
                   
                   
               
               
                 214129_at 
                 AI821791 
                 LOC727942 
                 similar to 
                 0.0262 
                 0.0645 
                 1.2 
               
               
                   
                   
                   
                 phosphodiesterase 
                   
                   
                   
               
               
                   
                   
                   
                 4D interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein isoform 2 
                   
                   
                   
               
               
                 202542_s_at 
                 NM_004757 
                 SCYE1 
                 small inducible 
                 0.0473 
                 0.3700 
                 1.2 
               
               
                   
                   
                   
                 cytokine subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 E, member 1 
                   
                   
                   
               
               
                   
                   
                   
                 (endothelial 
                   
                   
                   
               
               
                   
                   
                   
                 monocyte- 
                   
                   
                   
               
               
                   
                   
                   
                 activating) 
                   
                   
                   
               
               
                 212505_s_at 
                 AL110250 
                 KIAA0892 
                 KIAA0892 
                 0.0415 
                 0.3689 
                 1.2 
               
               
                 202495_at 
                 NM_003192 
                 TBCC 
                 tubulin folding 
                 0.0288 
                 0.1796 
                 1.2 
               
               
                   
                   
                   
                 cofactor C 
                   
                   
                   
               
               
                 201630_s_at 
                 NM_004300 
                 ACP1 
                 acid phosphatase 1, 
                 0.0049 
                 0.7714 
                 1.2 
               
               
                   
                   
                   
                 soluble 
                   
                   
                   
               
               
                 210027_s_at 
                 M80261 
                 APEX1 
                 APEX nuclease 
                 0.0015 
                 0.0441 
                 1.2 
               
               
                   
                   
                   
                 (multifunctional 
                   
                   
                   
               
               
                   
                   
                   
                 DNA repair 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme) 1 
                   
                   
                   
               
               
                 219442_at 
                 NM_024048 
                 C16orf67 
                 chromosome 16 
                 0.0205 
                 0.1694 
                 1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 67 
                   
                   
                   
               
               
                 202798_at 
                 NM_006323 
                 SEC24B 
                 SEC24 related 
                 0.0149 
                 0.4001 
                 1.2 
               
               
                   
                   
                   
                 gene family, 
                   
                   
                   
               
               
                   
                   
                   
                 member B ( S. cerevisiae ) 
                   
                   
                   
               
               
                 200595_s_at 
                 NM_003750 
                 EIF3S10 
                 eukaryotic 
                 0.0423 
                 0.3400 
                 1.2 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 10 theta, 
                   
                   
                   
               
               
                   
                   
                   
                 150/170 kDa 
                   
                   
                   
               
               
                 215373_x_at 
                 AK022213 
                 FLJ12151 
                 hypothetical 
                 0.0344 
                 0.2990 
                 1.2 
               
               
                   
                   
                   
                 protein FLJ12151 
                   
                   
                   
               
               
                 214150_x_at 
                 BE043477 
                 ATP6V0E1 
                 ATPase, H+ 
                 0.0097 
                 0.0385 
                 1.2 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 lysosomal 9 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 V0 subunit e1 
                   
                   
                   
               
               
                 213223_at 
                 AK025866 
                 RPL28 
                 ribosomal protein 
                 0.0186 
                 0.2522 
                 1.2 
               
               
                   
                   
                   
                 L28 
                   
                   
                   
               
               
                 206770_s_at 
                 NM_012243 
                 SLC35A3 
                 solute carrier 
                 0.0385 
                 0.1965 
                 1.2 
               
               
                   
                   
                   
                 family 35 (UDP-N- 
                   
                   
                   
               
               
                   
                   
                   
                 acetylglucosamine 
                   
                   
                   
               
               
                   
                   
                   
                 (UDP-GlcNAc) 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member A3 
                   
                   
                   
               
               
                 200032_s_at 
                 NM_000661 
                 RPL9 
                 ribosomal protein 
                 0.0064 
                 0.1269 
                 1.2 
               
               
                   
                   
                   
                 L9 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L9 
                   
                   
                   
               
               
                 200089_s_at 
                 AI953886 
                 RPL4 
                 ribosomal protein 
                 0.0011 
                 0.1019 
                 1.2 
               
               
                   
                   
                   
                 L4 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L4 
                   
                   
                   
               
               
                 218936_s_at 
                 NM_014167 
                 CCDC59 
                 coiled-coil domain 
                 0.0401 
                 0.1497 
                 1.2 
               
               
                   
                   
                   
                 containing 59 
                   
                   
                   
               
               
                 200013_at 
                 NM_000986 
                 RPL24 
                 ribosomal protein 
                 0.0012 
                 0.0506 
                 1.2 
               
               
                   
                   
                   
                 L24 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein L24 
                   
                   
                   
               
               
                 206551_x_at 
                 NM_017644 
                 KLHL24 
                 kelch-like 24 
                 0.0102 
                 0.0791 
                 1.2 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 205125_at 
                 NM_006225 
                 PLCD1 
                 phospholipase C, 
                 0.0415 
                 0.4391 
                 1.2 
               
               
                   
                   
                   
                 delta 1 
                   
                   
                   
               
               
                 201352_at 
                 NM_014263 
                 YME1L1 
                 YME1-like 1 ( S. cerevisiae ) 
                 0.0080 
                 0.0645 
                 1.2 
               
               
                 209049_s_at 
                 BC001004 
                 PRKCBP1 
                 protein kinase C 
                 0.0193 
                 0.1143 
                 1.2 
               
               
                   
                   
                   
                 binding protein 1 
                   
                   
                   
               
               
                 200781_s_at 
                 NM_001019 
                 RPS15A 
                 ribosomal protein 
                 0.0012 
                 0.0252 
                 1.2 
               
               
                   
                   
                   
                 S15a 
                   
                   
                   
               
               
                 208759_at 
                 AF240468 
                 IKBKB /// 
                 inhibitor of kappa 
                 0.0459 
                 0.9106 
                 1.2 
               
               
                   
                   
                 NCSTN 
                 light polypeptide 
                   
                   
                   
               
               
                   
                   
                   
                 gene enhancer in 
                   
                   
                   
               
               
                   
                   
                   
                 B-cells, kinase beta 
                   
                   
                   
               
               
                   
                   
                   
                 /// nicastrin 
                   
                   
                   
               
               
                 202536_at 
                 AK002165 
                 CHMP2B 
                 chromatin 
                 0.0369 
                 0.0552 
                 1.2 
               
               
                   
                   
                   
                 modifying protein 
                   
                   
                   
               
               
                   
                   
                   
                 2B 
                   
                   
                   
               
               
                 208025_s_at 
                 NM_003483 
                 HMGA2 
                 high mobility 
                 0.0144 
                 0.0506 
                 1.2 
               
               
                   
                   
                   
                 group AT-hook 2 
                   
                   
                   
               
               
                   
                   
                   
                 /// high mobility 
                   
                   
                   
               
               
                   
                   
                   
                 group AT-hook 2 
                   
                   
                   
               
               
                 208137_x_at 
                 NM_030972 
                 ZNF611 
                 zinc finger protein 
                 0.0034 
                 0.0383 
                 1.2 
               
               
                   
                   
                 /// 
                 611 /// zinc finger 
                   
                   
                   
               
               
                   
                   
                 LOC731901 
                 protein 611 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to zinc 
                   
                   
                   
               
               
                   
                   
                   
                 finger protein 160 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to zinc 
                   
                   
                   
               
               
                   
                   
                   
                 finger protein 160 
                   
                   
                   
               
               
                 200081_s_at 
                 BE741754 
                 RPS6 
                 ribosomal protein 
                 0.0029 
                 0.0971 
                 1.2 
               
               
                   
                   
                   
                 S6 /// ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S6 
                   
                   
                   
               
               
                 200862_at 
                 NM_014762 
                 DHCR24 
                 24- 
                 0.0001 
                 0.0261 
                 −3.1 
               
               
                   
                   
                   
                 dehydrocholesterol 
                   
                   
                   
               
               
                   
                   
                   
                 reductase 
                   
                   
                   
               
               
                 201287_s_at 
                 NM_002997 
                 SDC1 
                 syndecan 1 
                 0.0011 
                 0.1550 
                 −2.2 
               
               
                 209146_at 
                 AV704962 
                 SC4MOL 
                 sterol-C4-methyl 
                 0.0013 
                 0.3139 
                 −2.1 
               
               
                   
                   
                   
                 oxidase-like 
                   
                   
                   
               
               
                 209218_at 
                 AF098865 
                 SQLE 
                 squalene epoxidase 
                 0.0012 
                 0.6633 
                 −2.1 
               
               
                 202613_at 
                 NM_001905 
                 CTPS 
                 CTP synthase 
                 0.0012 
                 0.3142 
                 −2.0 
               
               
                 212218_s_at 
                 AI954041 
                 FASN 
                 fatty acid synthase 
                 0.0006 
                 0.0369 
                 −2.0 
               
               
                 201609_x_at 
                 AL578502 
                 ICMT 
                 isoprenylcysteine 
                 0.0024 
                 0.8332 
                 −1.9 
               
               
                   
                   
                   
                 carboxyl 
                   
                   
                   
               
               
                   
                   
                   
                 methyltransferase 
                   
                   
                   
               
               
                 210950_s_at 
                 BC003573 
                 FDFT1 
                 farnesyl- 
                 0.0002 
                 0.0274 
                 −1.9 
               
               
                   
                   
                   
                 diphosphate 
                   
                   
                   
               
               
                   
                   
                   
                 farnesyltransferase 1 
                   
                   
                   
               
               
                 201790_s_at 
                 AW150953 
                 DHCR7 
                 7- 
                 0.0036 
                 0.9588 
                 −1.9 
               
               
                   
                   
                   
                 dehydrocholesterol 
                   
                   
                   
               
               
                   
                   
                   
                 reductase 
                   
                   
                   
               
               
                 201475_x_at 
                 NM_004990 
                 MARS 
                 methionine-tRNA 
                 0.0005 
                 0.2911 
                 −1.9 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 221750_at 
                 BG035985 
                 HMGCS1 
                 3-hydroxy-3- 
                 0.0030 
                 0.4659 
                 −1.9 
               
               
                   
                   
                   
                 methylglutaryl- 
                   
                   
                   
               
               
                   
                   
                   
                 Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 synthase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (soluble) 
                   
                   
                   
               
               
                 200832_s_at 
                 AB032261 
                 SCD 
                 stearoyl-CoA 
                 0.0012 
                 0.1157 
                 −1.8 
               
               
                   
                   
                   
                 desaturase (delta-9- 
                   
                   
                   
               
               
                   
                   
                   
                 desaturase) 
                   
                   
                   
               
               
                 202580_x_at 
                 NM_021953 
                 FOXM1 
                 forkhead box M1 
                 0.0019 
                 0.0660 
                 −1.8 
               
               
                 205534_at 
                 NM_002589 
                 PCDH7 
                 BH-protocadherin 
                 0.0012 
                 0.0452 
                 −1.8 
               
               
                   
                   
                   
                 (brain-heart) 
                   
                   
                   
               
               
                 208002_s_at 
                 NM_007274 
                 ACOT7 
                 acyl-CoA 
                 0.0043 
                 0.1221 
                 −1.8 
               
               
                   
                   
                   
                 thioesterase 7 
                   
                   
                   
               
               
                 208881_x_at 
                 BC005247 
                 IDI1 
                 isopentenyl- 
                 0.0012 
                 0.2090 
                 −1.8 
               
               
                   
                   
                   
                 diphosphate delta 
                   
                   
                   
               
               
                   
                   
                   
                 isomerase 1 
                   
                   
                   
               
               
                 210793_s_at 
                 U41815 
                 NUP98 
                 nucleoporin 98 kDa 
                 0.0014 
                 0.5809 
                 −1.8 
               
               
                 211136_s_at 
                 BC004865 
                 CLPTM1 
                 cleft lip and palate 
                 0.0007 
                 0.0264 
                 −1.8 
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 transmembrane 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 201490_s_at 
                 NM_005729 
                 PPIF 
                 peptidylprolyl 
                 0.0015 
                 0.6082 
                 −1.8 
               
               
                   
                   
                   
                 isomerase F 
                   
                   
                   
               
               
                   
                   
                   
                 (cyclophilin F) 
                   
                   
                   
               
               
                 200987_x_at 
                 AA758755 
                 PSME3 
                 proteasome 
                 0.0015 
                 0.8757 
                 −1.8 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 activator subunit 3 
                   
                   
                   
               
               
                   
                   
                   
                 (PA28 gamma; Ki) 
                   
                   
                   
               
               
                 212009_s_at 
                 AL553320 
                 STIP1 
                 stress-induced- 
                 0.0011 
                 0.5636 
                 −1.8 
               
               
                   
                   
                   
                 phosphoprotein 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Hsp70/Hsp90- 
                   
                   
                   
               
               
                   
                   
                   
                 organizing protein) 
                   
                   
                   
               
               
                 202587_s_at 
                 BC001116 
                 AK1 
                 adenylate kinase 1 
                 0.0014 
                 0.8539 
                 −1.8 
               
               
                 217943_s_at 
                 NM_018067 
                 RPRC1 
                 arginine/proline 
                 0.0036 
                 0.7553 
                 −1.8 
               
               
                   
                   
                   
                 rich coiled-coil 1 
                   
                   
                   
               
               
                 201564_s_at 
                 NM_003088 
                 FSCN1 
                 fascin homolog 1, 
                 0.0007 
                 0.0411 
                 −1.8 
               
               
                   
                   
                   
                 actin-bundling 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 ( Strongylocentrotus   
                   
                   
                   
               
               
                   
                   
                   
                   purpuratus ) 
                   
                   
                   
               
               
                 210337_s_at 
                 U18197 
                 ACLY 
                 ATP citrate lyase 
                 0.0009 
                 0.2586 
                 −1.8 
               
               
                 201679_at 
                 BE646076 
                 ARS2 
                 ARS2 protein 
                 0.0019 
                 0.2538 
                 −1.7 
               
               
                 217992_s_at 
                 NM_024329 
                 EFHD2 
                 EF-hand domain 
                 0.0015 
                 0.2671 
                 −1.7 
               
               
                   
                   
                   
                 family, member D2 
                   
                   
                   
               
               
                 202052_s_at 
                 NM_015577 
                 RAI14 
                 retinoic acid 
                 0.0160 
                 0.7493 
                 −1.7 
               
               
                   
                   
                   
                 induced 14 
                   
                   
                   
               
               
                 201626_at 
                 BG292233 
                 INSIG1 
                 insulin induced 
                 0.0071 
                 0.5750 
                 −1.7 
               
               
                   
                   
                   
                 gene 1 
                   
                   
                   
               
               
                 202743_at 
                 BE622627 
                 PIK3R3 
                 phosphoinositide- 
                 0.0007 
                 0.2808 
                 −1.7 
               
               
                   
                   
                   
                 3-kinase, 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory subunit 
                   
                   
                   
               
               
                   
                   
                   
                 3 (p55, gamma) 
                   
                   
                   
               
               
                 207622_s_at 
                 NM_005692 
                 ABCF2 
                 ATP-binding 
                 0.0007 
                 0.5505 
                 −1.7 
               
               
                   
                   
                   
                 cassette, sub- 
                   
                   
                   
               
               
                   
                   
                   
                 family F (GCN20), 
                   
                   
                   
               
               
                   
                   
                   
                 member 2 
                   
                   
                   
               
               
                 210973_s_at 
                 M63889 
                 FGFR1 
                 fibroblast growth 
                 0.0017 
                 0.0348 
                 −1.7 
               
               
                   
                   
                   
                 factor receptor 1 
                   
                   
                   
               
               
                   
                   
                   
                 (fms-related 
                   
                   
                   
               
               
                   
                   
                   
                 tyrosine kinase 2, 
                   
                   
                   
               
               
                   
                   
                   
                 Pfeiffer syndrome) 
                   
                   
                   
               
               
                 201281_at 
                 NM_007002 
                 ADRM1 
                 adhesion regulating 
                 0.0004 
                 0.7557 
                 −1.7 
               
               
                   
                   
                   
                 molecule 1 
                   
                   
                   
               
               
                 207945_s_at 
                 NM_001893 
                 CSNK1D 
                 casein kinase 1, 
                 0.0008 
                 0.0981 
                 −1.7 
               
               
                   
                   
                   
                 delta 
                   
                   
                   
               
               
                 208637_x_at 
                 BC003576 
                 ACTN1 
                 actinin, alpha 1 
                 0.0010 
                 0.3106 
                 −1.7 
               
               
                 212563_at 
                 BG491842 
                 BOP1 /// 
                 block of 
                 0.0025 
                 0.1767 
                 −1.7 
               
               
                   
                   
                 LOC727967 
                 proliferation 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to block of 
                   
                   
                   
               
               
                   
                   
                   
                 proliferation 1 
                   
                   
                   
               
               
                 219894_at 
                 NM_019066 
                 MAGEL2 
                 MAGE-like 2 
                 0.0033 
                 0.8372 
                 −1.7 
               
               
                 205483_s_at 
                 NM_005101 
                 ISG15 
                 ISG15 ubiquitin- 
                 0.0296 
                 0.9106 
                 −1.7 
               
               
                   
                   
                   
                 like modifier 
                   
                   
                   
               
               
                 218494_s_at 
                 NM_020062 
                 SLC2A4RG 
                 SLC2A4 regulator 
                 0.0007 
                 0.0645 
                 −1.7 
               
               
                 213986_s_at 
                 AI805266 
                 C19orf6 
                 chromosome 19 
                 0.0074 
                 0.0807 
                 −1.7 
               
               
                   
                   
                   
                 open reading frame 6 
                   
                   
                   
               
               
                 212983_at 
                 NM_005343 
                 HRAS 
                 v-Ha-ras Harvey 
                 0.0011 
                 0.7695 
                 −1.7 
               
               
                   
                   
                   
                 rat sarcoma viral 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene homolog 
                   
                   
                   
               
               
                 204285_s_at 
                 AI857639 
                 PMAIP1 
                 phorbol-12- 
                 0.0041 
                 0.0964 
                 −1.7 
               
               
                   
                   
                   
                 myristate-13- 
                   
                   
                   
               
               
                   
                   
                   
                 acetate-induced 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 201516_at 
                 NM_003132 
                 SRM 
                 spermidine 
                 0.0005 
                 0.2652 
                 −1.7 
               
               
                   
                   
                   
                 synthase 
                   
                   
                   
               
               
                 219099_at 
                 NM_020375 
                 C12orf5 
                 chromosome 12 
                 0.0099 
                 0.3265 
                 −1.7 
               
               
                   
                   
                   
                 open reading frame 5 
                   
                   
                   
               
               
                 201695_s_at 
                 NM_000270 
                 NP 
                 nucleoside 
                 0.0031 
                 0.2128 
                 −1.7 
               
               
                   
                   
                   
                 phosphorylase 
                   
                   
                   
               
               
                 222155_s_at 
                 AK021918 
                 GPR172A 
                 G protein-coupled 
                 0.0061 
                 0.3703 
                 −1.7 
               
               
                   
                   
                   
                 receptor 172A 
                   
                   
                   
               
               
                 217025_s_at 
                 AL110225 
                 DBN1 
                 drebrin 1 
                 0.0015 
                 0.5175 
                 −1.6 
               
               
                 200720_s_at 
                 AL532341 
                 ACTR1A 
                 ARP1 actin-related 
                 0.0024 
                 0.3563 
                 −1.6 
               
               
                   
                   
                   
                 protein 1 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 A, centractin alpha 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 205858_at 
                 NM_002507 
                 NGFR 
                 nerve growth factor 
                 0.0361 
                 0.7526 
                 −1.6 
               
               
                   
                   
                   
                 receptor (TNFR 
                   
                   
                   
               
               
                   
                   
                   
                 superfamily, 
                   
                   
                   
               
               
                   
                   
                   
                 member 16) 
                   
                   
                   
               
               
                 218051_s_at 
                 NM_022908 
                 NT5DC2 
                 5′-nucleotidase 
                 0.0007 
                 0.0532 
                 −1.6 
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 202539_s_at 
                 AL518627 
                 HMGCR 
                 3-hydroxy-3- 
                 0.0047 
                 0.7250 
                 −1.6 
               
               
                   
                   
                   
                 methylglutaryl- 
                   
                   
                   
               
               
                   
                   
                   
                 Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 reductase 
                   
                   
                   
               
               
                 207824_s_at 
                 NM_002383 
                 MAZ 
                 MYC-associated 
                 0.0012 
                 0.0274 
                 −1.6 
               
               
                   
                   
                   
                 zinc finger protein 
                   
                   
                   
               
               
                   
                   
                   
                 (purine-binding 
                   
                   
                   
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 factor) 
                   
                   
                   
               
               
                 208962_s_at 
                 BE540552 
                 FADS1 
                 fatty acid 
                 0.0007 
                 0.0663 
                 −1.6 
               
               
                   
                   
                   
                 desaturase 1 
                   
                   
                   
               
               
                 212048_s_at 
                 AW245400 
                 YARS 
                 tyrosyl-tRNA 
                 0.0007 
                 0.0642 
                 −1.6 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 201277_s_at 
                 NM_004499 
                 HNRPAB 
                 heterogeneous 
                 0.0007 
                 0.0504 
                 −1.6 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 A/B 
                   
                   
                   
               
               
                 209608_s_at 
                 BC000408 
                 ACAT2 
                 acetyl-Coenzyme 
                 0.0015 
                 0.2423 
                 −1.6 
               
               
                   
                   
                   
                 A acetyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 2 (acetoacetyl 
                   
                   
                   
               
               
                   
                   
                   
                 Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 thiolase) 
                   
                   
                   
               
               
                 212907_at 
                 AI972416 
                 SLC30A1 
                 Solute carrier 
                 0.0161 
                 0.3563 
                 −1.6 
               
               
                   
                   
                   
                 family 30 (zinc 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 202852_s_at 
                 NM_024666 
                 FLJ11506 
                 hypothetical 
                 0.0069 
                 0.2746 
                 −1.6 
               
               
                   
                   
                   
                 protein FLJ11506 
                   
                   
                   
               
               
                 200664_s_at 
                 BG537255 
                 DNAJB1 
                 DnaJ (Hsp40) 
                 0.0008 
                 0.2350 
                 −1.6 
               
               
                   
                   
                   
                 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily B, 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 213492_at 
                 X06268 
                 COL2A1 
                 collagen, type II, 
                 0.0143 
                 0.1963 
                 −1.6 
               
               
                   
                   
                   
                 alpha 1 (primary 
                   
                   
                   
               
               
                   
                   
                   
                 osteoarthritis, 
                   
                   
                   
               
               
                   
                   
                   
                 spondyloepiphysea 
                   
                   
                   
               
               
                   
                   
                   
                 1 dysplasia, 
                   
                   
                   
               
               
                   
                   
                   
                 congenital) 
                   
                   
                   
               
               
                 201874_at 
                 BF978611 
                 MPZL1 
                 myelin protein 
                 0.0061 
                 0.3437 
                 −1.6 
               
               
                   
                   
                   
                 zero-like 1 
                   
                   
                   
               
               
                 200825_s_at 
                 NM_006389 
                 HYOU1 
                 hypoxia up- 
                 0.0013 
                 0.0376 
                 −1.6 
               
               
                   
                   
                   
                 regulated 1 
                   
                   
                   
               
               
                 212125_at 
                 NM_002883 
                 RANGAP1 
                 Ran GTPase 
                 0.0124 
                 0.2690 
                 −1.6 
               
               
                   
                   
                   
                 activating protein 1 
                   
                   
                   
               
               
                 203499_at 
                 NM_004431 
                 EPHA2 
                 EPH receptor A2 
                 0.0048 
                 0.7012 
                 −1.6 
               
               
                 220892_s_at 
                 NM_021154 
                 PSAT1 
                 phosphoserine 
                 0.0130 
                 0.3662 
                 −1.6 
               
               
                   
                   
                   
                 aminotransferase 1 
                   
                   
                   
               
               
                 201005_at 
                 NM_001769 
                 CD9 
                 CD9 molecule 
                 0.0012 
                 0.0733 
                 −1.6 
               
               
                 213523_at 
                 AI671049 
                 CCNE1 
                 cyclin E1 
                 0.0007 
                 0.1144 
                 −1.6 
               
               
                 221503_s_at 
                 AF034756 
                 KPNA3 
                 karyopherin alpha 
                 0.0042 
                 0.0834 
                 −1.6 
               
               
                   
                   
                   
                 3 (importin alpha 
                   
                   
                   
               
               
                   
                   
                   
                 4) 
                   
                   
                   
               
               
                 217762_s_at 
                 BE789881 
                 RAB31 
                 RAB31, member 
                 0.0068 
                 0.3313 
                 −1.6 
               
               
                   
                   
                   
                 RAS oncogene 
                   
                   
                   
               
               
                   
                   
                   
                 family 
                   
                   
                   
               
               
                 206491_s_at 
                 NM_003827 
                 NAPA 
                 N-ethylmaleimide- 
                 0.0043 
                 0.1666 
                 −1.6 
               
               
                   
                   
                   
                 sensitive factor 
                   
                   
                   
               
               
                   
                   
                   
                 attachment protein, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 222231_s_at 
                 AK025328 
                 LRRC59 
                 leucine rich repeat 
                 0.0012 
                 0.2297 
                 −1.6 
               
               
                   
                   
                   
                 containing 59 
                   
                   
                   
               
               
                 201167_x_at 
                 D13989 
                 ARHGDIA 
                 Rho GDP 
                 0.0069 
                 0.0544 
                 −1.6 
               
               
                   
                   
                   
                 dissociation 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor (GDI) 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 204141_at 
                 NM_001069 
                 TUBB2A 
                 tubulin, beta 2A 
                 0.0031 
                 0.7289 
                 −1.6 
               
               
                 200800_s_at 
                 NM_005345 
                 HSPA1A 
                 heat shock 70 kDa 
                 0.0047 
                 0.0547 
                 −1.6 
               
               
                   
                   
                 /// 
                 protein 1A /// heat 
                   
                   
                   
               
               
                   
                   
                 HSPA1B 
                 shock 70 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1B 
                   
                   
                   
               
               
                 213030_s_at 
                 AI688418 
                 PLXNA2 
                 plexin A2 
                 0.0019 
                 0.1469 
                 −1.6 
               
               
                 200078_s_at 
                 BC005876 
                 ATP6V0B 
                 ATPase, H+ 
                 0.0007 
                 0.1997 
                 −1.6 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 lysosomal 21 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 V0 subunit b /// 
                   
                   
                   
               
               
                   
                   
                   
                 ATPase, H+ 
                   
                   
                   
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 lysosomal 21 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 V0 subunit b 
                   
                   
                   
               
               
                 212501_at 
                 AL564683 
                 CEBPB 
                 CCAAT/enhancer 
                 0.0168 
                 0.7928 
                 −1.6 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 (C/EBP), beta 
                   
                   
                   
               
               
                 201248_s_at 
                 NM_004599 
                 SREBF2 
                 sterol regulatory 
                 0.0036 
                 0.0990 
                 −1.6 
               
               
                   
                   
                   
                 element binding 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 2 
                   
                   
                   
               
               
                 217717_s_at 
                 BF246499 
                 YWHAB 
                 tyrosine 3- 
                 0.0274 
                 0.9884 
                 −1.6 
               
               
                   
                   
                   
                 monooxygenase/tryptophan 
                   
                   
                   
               
               
                   
                   
                   
                 5- 
                   
                   
                   
               
               
                   
                   
                   
                 monooxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 activation protein, 
                   
                   
                   
               
               
                   
                   
                   
                 beta polypeptide 
                   
                   
                   
               
               
                 205417_s_at 
                 NM_004393 
                 DAG1 
                 dystroglycan 1 
                 0.0024 
                 0.1175 
                 −1.6 
               
               
                   
                   
                   
                 (dystrophin- 
                   
                   
                   
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 glycoprotein 1) 
                   
                   
                   
               
               
                 208625_s_at 
                 AF104913 
                 EIF4G1 
                 eukaryotic 
                 0.0040 
                 0.5095 
                 −1.6 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 4 
                   
                   
                   
               
               
                   
                   
                   
                 gamma, 1 
                   
                   
                   
               
               
                 205047_s_at 
                 NM_001673 
                 ASNS 
                 asparagine 
                 0.0034 
                 0.4312 
                 −1.6 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 211899_s_at 
                 AF082185 
                 TRAF4 
                 TNF receptor- 
                 0.0152 
                 0.4299 
                 −1.6 
               
               
                   
                   
                   
                 associated factor 4 
                   
                   
                   
               
               
                 200753_x_at 
                 BE866585 
                 SFRS2 
                 splicing factor, 
                 0.0027 
                 0.6707 
                 −1.5 
               
               
                   
                   
                   
                 arginine/serine-rich 2 
                   
                   
                   
               
               
                 211066_x_at 
                 BC006439 
                 PCDHGC3 
                 protocadherin 
                 0.0100 
                 0.7921 
                 −1.5 
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGB4 
                 C, 3 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGA8 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 C, 3 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGA12 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGC5 
                 B, 4 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGC4 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 B, 4 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGB7 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGB6 
                 A, 8 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGB5 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 A, 8 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGB3 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGB2 
                 A, 12 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGB1 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 A, 12 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGA11 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGA10 
                 C, 5 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGA9 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 C, 5 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGA7 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGA6 
                 C, 4 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGA5 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 C, 4 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGA4 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 /// 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 PCDHGA3 
                 B, 7 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                 PCDHGA2 
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                 /// 
                 B, 7 /// 
                   
                   
                   
               
               
                   
                   
                 PCDHGA1 
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 6 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 6 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 5 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 5 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 2 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 2 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 B, 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 A, 11 /// 
                   
                   
                   
               
               
                   
                   
                   
                 protocadherin 
                   
                   
                   
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 A, 11 /// protoc 
                   
                   
                   
               
               
                 221539_at 
                 AB044548 
                 EIF4EBP1 
                 eukaryotic 
                 0.0005 
                 0.1625 
                 −1.5 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 4E 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 1 
                   
                   
                   
               
               
                 212020_s_at 
                 AU152107 
                 MKI67 
                 antigen identified 
                 0.0100 
                 0.3569 
                 −1.5 
               
               
                   
                   
                   
                 by monoclonal 
                   
                   
                   
               
               
                   
                   
                   
                 antibody Ki-67 
                   
                   
                   
               
               
                 212186_at 
                 BE855983 
                 ACACA 
                 acetyl-Coenzyme 
                 0.0046 
                 0.7009 
                 −1.5 
               
               
                   
                   
                   
                 A carboxylase 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 200736_s_at 
                 NM_000581 
                 GPX1 
                 glutathione 
                 0.0005 
                 0.0958 
                 −1.5 
               
               
                   
                   
                   
                 peroxidase 1 
                   
                   
                   
               
               
                 212110_at 
                 D31887 
                 SLC39A14 
                 solute carrier 
                 0.0039 
                 0.1774 
                 −1.5 
               
               
                   
                   
                   
                 family 39 (zinc 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 14 
                   
                   
                   
               
               
                 221269_s_at 
                 NM_031286 
                 SH3BGRL3 
                 SH3 domain 
                 0.0022 
                 0.1530 
                 −1.5 
               
               
                   
                   
                   
                 binding glutamic 
                   
                   
                   
               
               
                   
                   
                   
                 acid-rich protein 
                   
                   
                   
               
               
                   
                   
                   
                 like 3 /// SH3 
                   
                   
                   
               
               
                   
                   
                   
                 domain binding 
                   
                   
                   
               
               
                   
                   
                   
                 glutamic acid-rich 
                   
                   
                   
               
               
                   
                   
                   
                 protein like 3 
                   
                   
                   
               
               
                 218866_s_at 
                 NM_016310 
                 POLR3K 
                 polymerase (RNA) 
                 0.0006 
                 0.0499 
                 −1.5 
               
               
                   
                   
                   
                 III (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide K, 
                   
                   
                   
               
               
                   
                   
                   
                 12.3 kDa 
                   
                   
                   
               
               
                 208998_at 
                 U94592 
                 UCP2 
                 uncoupling protein 
                 0.0064 
                 0.2296 
                 −1.5 
               
               
                   
                   
                   
                 2 (mitochondrial, 
                   
                   
                   
               
               
                   
                   
                   
                 proton carrier) 
                   
                   
                   
               
               
                 201920_at 
                 NM_005415 
                 SLC20A1 
                 solute carrier 
                 0.0127 
                 0.2383 
                 −1.5 
               
               
                   
                   
                   
                 family 20 
                   
                   
                   
               
               
                   
                   
                   
                 (phosphate 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 217140_s_at 
                 AJ002428 
                 VDAC1 
                 voltage-dependent 
                 0.0011 
                 0.2544 
                 −1.5 
               
               
                   
                   
                   
                 anion channel 1 
                   
                   
                   
               
               
                 204178_s_at 
                 NM_006328 
                 RBM14 
                 RNA binding motif 
                 0.0012 
                 0.0244 
                 −1.5 
               
               
                   
                   
                   
                 protein 14 
                   
                   
                   
               
               
                 208977_x_at 
                 BC004188 
                 TUBB2C 
                 tubulin, beta 2C 
                 0.0007 
                 0.1351 
                 −1.5 
               
               
                 55692_at 
                 W22924 
                 ELMO2 
                 engulfment and 
                 0.0193 
                 0.7394 
                 −1.5 
               
               
                   
                   
                   
                 cell motility 2 
                   
                   
                   
               
               
                 201954_at 
                 NM_005720 
                 ARPC1B 
                 actin related 
                 0.0090 
                 0.6520 
                 −1.5 
               
               
                   
                   
                 /// 
                 protein 2/3 
                   
                   
                   
               
               
                   
                   
                 LOC653888 
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 1B, 41 kDa /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to Actin- 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex subunit 
                   
                   
                   
               
               
                   
                   
                   
                 1B (ARP2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex 41 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 subunit) (p41- 
                   
                   
                   
               
               
                   
                   
                   
                 ARC) 
                   
                   
                   
               
               
                 52164_at 
                 AA065185 
                 C11orf24 
                 chromosome 11 
                 0.0012 
                 0.3796 
                 −1.5 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 24 
                   
                   
                   
               
               
                 200884_at 
                 NM_001823 
                 CKB 
                 creatine kinase, 
                 0.0141 
                 0.1787 
                 −1.5 
               
               
                   
                   
                   
                 brain 
                   
                   
                   
               
               
                 200744_s_at 
                 AI741124 
                 GNB1 
                 guanine nucleotide 
                 0.0006 
                 0.0653 
                 −1.5 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein), beta 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 1 
                   
                   
                   
               
               
                 200617_at 
                 NM_014730 
                 KIAA0152 
                 KIAA0152 
                 0.0042 
                 0.6385 
                 −1.5 
               
               
                 203085_s_at 
                 BC000125 
                 TGFB1 
                 transforming 
                 0.0122 
                 0.2679 
                 −1.5 
               
               
                   
                   
                   
                 growth factor, beta 
                   
                   
                   
               
               
                   
                   
                   
                 1 (Camurati- 
                   
                   
                   
               
               
                   
                   
                   
                 Engelmann 
                   
                   
                   
               
               
                   
                   
                   
                 disease) 
                   
                   
                   
               
               
                 222278_at 
                 AW969655 
                 — 
                 Transcribed locus, 
                 0.0420 
                 0.6056 
                 −1.5 
               
               
                   
                   
                   
                 moderately similar 
                   
                   
                   
               
               
                   
                   
                   
                 to 
                   
                   
                   
               
               
                   
                   
                   
                 XP_001002661.1 
                   
                   
                   
               
               
                   
                   
                   
                 hypothetical 
                   
                   
                   
               
               
                   
                   
                   
                 protein [ Mus   
                   
                   
                   
               
               
                   
                   
                   
                   musculus ] 
                   
                   
                   
               
               
                 212300_at 
                 AL049795 
                 TXLNA 
                 taxilin alpha 
                 0.0028 
                 0.2423 
                 −1.5 
               
               
                 211237_s_at 
                 AF202063 
                 FGFR4 
                 fibroblast growth 
                 0.0018 
                 0.0648 
                 −1.5 
               
               
                   
                   
                   
                 factor receptor 4 
                   
                   
                   
               
               
                 201700_at 
                 NM_001760 
                 CCND3 
                 cyclin D3 
                 0.0018 
                 0.3480 
                 −1.5 
               
               
                 214677_x_at 
                 X57812 
                 IGL@ /// 
                 immunoglobulin 
                 0.0075 
                 0.3646 
                 −1.5 
               
               
                   
                   
                 IGLV4-3 
                 lambda locus /// 
                   
                   
                   
               
               
                   
                   
                 /// IGLV3- 
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                 25 /// 
                 lambda variable 4- 
                   
                   
                   
               
               
                   
                   
                 IGLV2-14 
                 3 /// 
                   
                   
                   
               
               
                   
                   
                 /// IGLJ3 
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 lambda variable 3- 
                   
                   
                   
               
               
                   
                   
                   
                 25 /// 
                   
                   
                   
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 lambda variable 2- 
                   
                   
                   
               
               
                   
                   
                   
                 14 /// 
                   
                   
                   
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 lambda joining 3 
                   
                   
                   
               
               
                 214845_s_at 
                 AF257659 
                 CALU 
                 calumenin 
                 0.0069 
                 0.6021 
                 −1.5 
               
               
                 206463_s_at 
                 NM_005794 
                 DHRS2 
                 dehydrogenase/reductase 
                 0.0135 
                 0.4760 
                 −1.5 
               
               
                   
                   
                   
                 (SDR 
                   
                   
                   
               
               
                   
                   
                   
                 family) member 2 
                   
                   
                   
               
               
                 204768_s_at 
                 NM_004111 
                 FEN1 
                 flap structure- 
                 0.0007 
                 0.1484 
                 −1.5 
               
               
                   
                   
                   
                 specific 
                   
                   
                   
               
               
                   
                   
                   
                 endonuclease 1 
                   
                   
                   
               
               
                 213547_at 
                 AB014567 
                 CAND2 
                 cullin-associated 
                 0.0025 
                 0.0807 
                 −1.5 
               
               
                   
                   
                   
                 and neddylation- 
                   
                   
                   
               
               
                   
                   
                   
                 dissociated 2 
                   
                   
                   
               
               
                   
                   
                   
                 (putative) 
                   
                   
                   
               
               
                 217861_s_at 
                 NM_013388 
                 PREB 
                 prolactin 
                 0.0012 
                 0.8030 
                 −1.5 
               
               
                   
                   
                   
                 regulatory element 
                   
                   
                   
               
               
                   
                   
                   
                 binding 
                   
                   
                   
               
               
                 209361_s_at 
                 BC004153 
                 PCBP4 
                 poly(rC) binding 
                 0.0022 
                 0.1080 
                 −1.5 
               
               
                   
                   
                   
                 protein 4 
                   
                   
                   
               
               
                 210317_s_at 
                 U28936 
                 YWHAE 
                 tyrosine 3- 
                 0.0050 
                 0.0441 
                 −1.5 
               
               
                   
                   
                   
                 monooxygenase/tryptophan 
                   
                   
                   
               
               
                   
                   
                   
                 5- 
                   
                   
                   
               
               
                   
                   
                   
                 monooxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 activation protein, 
                   
                   
                   
               
               
                   
                   
                   
                 epsilon polypeptide 
                   
                   
                   
               
               
                 203968_s_at 
                 NM_001254 
                 CDC6 
                 cell division cycle 
                 0.0012 
                 0.1235 
                 −1.5 
               
               
                   
                   
                   
                 6 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 218888_s_at 
                 NM_018092 
                 NETO2 
                 neuropilin (NRP) 
                 0.0044 
                 0.3076 
                 −1.5 
               
               
                   
                   
                   
                 and tolloid (TLL)- 
                   
                   
                   
               
               
                   
                   
                   
                 like 2 
                   
                   
                   
               
               
                 209336_at 
                 U56085 
                 PWP2 
                 PWP2 periodic 
                 0.0065 
                 0.9234 
                 −1.5 
               
               
                   
                   
                   
                 tryptophan protein 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 203737_s_at 
                 NM_015062 
                 PPRC1 
                 peroxisome 
                 0.0136 
                 0.5419 
                 −1.5 
               
               
                   
                   
                   
                 proliferator- 
                   
                   
                   
               
               
                   
                   
                   
                 activated receptor 
                   
                   
                   
               
               
                   
                   
                   
                 gamma, 
                   
                   
                   
               
               
                   
                   
                   
                 coactivator-related 1 
                   
                   
                   
               
               
                 202478_at 
                 NM_021643 
                 TRIB2 
                 tribbles homolog 2 
                 0.0026 
                 0.2666 
                 −1.5 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 208891_at 
                 BC003143 
                 DUSP6 
                 dual specificity 
                 0.0069 
                 0.0576 
                 −1.5 
               
               
                   
                   
                   
                 phosphatase 6 
                   
                   
                   
               
               
                 208815_x_at 
                 AB023420 
                 HSPA4 
                 heat shock 70 kDa 
                 0.0025 
                 0.0549 
                 −1.5 
               
               
                   
                   
                   
                 protein 4 
                   
                   
                   
               
               
                 204087_s_at 
                 NM_021095 
                 SLC5A6 
                 solute carrier 
                 0.0035 
                 0.7493 
                 −1.5 
               
               
                   
                   
                   
                 family 5 (sodium- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent vitamin 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 6 
                   
                   
                   
               
               
                 203109_at 
                 NM_003969 
                 UBE2M 
                 ubiquitin- 
                 0.0020 
                 0.7428 
                 −1.5 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2M 
                   
                   
                   
               
               
                   
                   
                   
                 (UBC12 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 208693_s_at 
                 D30658 
                 GARS 
                 glycyl-tRNA 
                 0.0016 
                 0.4086 
                 −1.5 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 220651_s_at 
                 NM_018518 
                 MCM10 
                 MCM10 
                 0.0017 
                 0.1151 
                 −1.5 
               
               
                   
                   
                   
                 minichromosome 
                   
                   
                   
               
               
                   
                   
                   
                 maintenance 
                   
                   
                   
               
               
                   
                   
                   
                 deficient 10 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 217808_s_at 
                 NM_024117 
                 MAPKAP1 
                 mitogen-activated 
                 0.0007 
                 0.2075 
                 −1.5 
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 associated protein 1 
                   
                   
                   
               
               
                 201198_s_at 
                 AI860431 
                 PSMD1 
                 proteasome 
                 0.0009 
                 0.2829 
                 −1.5 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, non- 
                   
                   
                   
               
               
                   
                   
                   
                 ATPase, 1 
                   
                   
                   
               
               
                 201193_at 
                 NM_005896 
                 IDH1 
                 isocitrate 
                 0.0049 
                 0.4382 
                 −1.5 
               
               
                   
                   
                   
                 dehydrogenase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (NADP+), soluble 
                   
                   
                   
               
               
                 201551_s_at 
                 J03263 
                 LAMP1 
                 lysosomal- 
                 0.0031 
                 0.0506 
                 −1.5 
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein 1 
                   
                   
                   
               
               
                 212680_x_at 
                 BE305165 
                 PPP1R14B 
                 protein 
                 0.0006 
                 0.2726 
                 −1.5 
               
               
                   
                   
                   
                 phosphatase 1, 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory 
                   
                   
                   
               
               
                   
                   
                   
                 (inhibitor) subunit 
                   
                   
                   
               
               
                   
                   
                   
                 14B 
                   
                   
                   
               
               
                 201618_x_at 
                 NM_003801 
                 GPAA1 
                 glycosylphosphatidylinositol 
                 0.0100 
                 0.0923 
                 −1.5 
               
               
                   
                   
                   
                 anchor 
                   
                   
                   
               
               
                   
                   
                   
                 attachment protein 
                   
                   
                   
               
               
                   
                   
                   
                 1 homolog (yeast) 
                   
                   
                   
               
               
                 200886_s_at 
                 NM_002629 
                 PGAM1 
                 phosphoglycerate 
                 0.0007 
                 0.4197 
                 −1.5 
               
               
                   
                   
                 /// 
                 mutase 1 (brain) /// 
                   
                   
                   
               
               
                   
                   
                 LOC642969 
                 similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 Phosphoglycerate 
                   
                   
                   
               
               
                   
                   
                 LOC643576 
                 mutase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Phosphoglycerate 
                   
                   
                   
               
               
                   
                   
                   
                 mutase isozyme B) 
                   
                   
                   
               
               
                   
                   
                   
                 (PGAM-B) (BPG- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent PGAM 
                   
                   
                   
               
               
                   
                   
                   
                 1) /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Phosphoglycerate 
                   
                   
                   
               
               
                   
                   
                   
                 mutase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Phosphoglycerate 
                   
                   
                   
               
               
                   
                   
                   
                 mutase isozyme B) 
                   
                   
                   
               
               
                   
                   
                   
                 (PGAM-B) (BPG- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent PGAM 
                   
                   
                   
               
               
                   
                   
                   
                 1) 
                   
                   
                   
               
               
                 212419_at 
                 AA131324 
                 C10orf56 
                 chromosome 10 
                 0.0016 
                 0.3823 
                 −1.5 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 56 
                   
                   
                   
               
               
                 212242_at 
                 AL565074 
                 TUBA1 
                 tubulin, alpha 1 
                 0.0007 
                 0.1083 
                 −1.5 
               
               
                 221640_s_at 
                 AF274972 
                 LRDD 
                 leucine-rich repeats 
                 0.0071 
                 0.0995 
                 −1.5 
               
               
                   
                   
                   
                 and death domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                 209035_at 
                 M69148 
                 MDK 
                 midkine (neurite 
                 0.0009 
                 0.0727 
                 −1.5 
               
               
                   
                   
                   
                 growth-promoting 
                   
                   
                   
               
               
                   
                   
                   
                 factor 2) 
                   
                   
                   
               
               
                 200787_s_at 
                 BC002426 
                 PEA15 
                 phosphoprotein 
                 0.0016 
                 0.4992 
                 −1.5 
               
               
                   
                   
                   
                 enriched in 
                   
                   
                   
               
               
                   
                   
                   
                 astrocytes 15 
                   
                   
                   
               
               
                 212041_at 
                 AL566172 
                 ATP6V0D1 
                 ATPase, H+ 
                 0.0078 
                 0.7937 
                 −1.5 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 lysosomal 38 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 V0 subunit d1 
                   
                   
                   
               
               
                 218115_at 
                 NM_018154 
                 ASF1B 
                 ASF1 anti- 
                 0.0066 
                 0.2165 
                 −1.5 
               
               
                   
                   
                   
                 silencing function 
                   
                   
                   
               
               
                   
                   
                   
                 1 homolog B ( S. cerevisiae ) 
                   
                   
                   
               
               
                 201710_at 
                 NM_002466 
                 MYBL2 
                 v-myb 
                 0.0036 
                 0.1147 
                 −1.5 
               
               
                   
                   
                   
                 myeloblastosis 
                   
                   
                   
               
               
                   
                   
                   
                 viral oncogene 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (avian)- 
                   
                   
                   
               
               
                   
                   
                   
                 like 2 
                   
                   
                   
               
               
                 205748_s_at 
                 NM_017876 
                 RNF126 
                 ring finger protein 
                 0.0056 
                 0.6038 
                 −1.5 
               
               
                   
                   
                   
                 126 
                   
                   
                   
               
               
                 203359_s_at 
                 AL525412 
                 MYCBP 
                 c-myc binding 
                 0.0071 
                 0.2121 
                 −1.5 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212174_at 
                 W02312 
                 AK2 
                 adenylate kinase 2 
                 0.0014 
                 0.2498 
                 −1.5 
               
               
                 212441_at 
                 D86985 
                 KIAA0232 
                 KIAA0232 gene 
                 0.0039 
                 0.0993 
                 −1.5 
               
               
                   
                   
                   
                 product 
                   
                   
                   
               
               
                 221972_s_at 
                 AL571362 
                 SDF4 
                 stromal cell 
                 0.0020 
                 0.0645 
                 −1.5 
               
               
                   
                   
                   
                 derived factor 4 
                   
                   
                   
               
               
                 207088_s_at 
                 NM_003562 
                 SLC25A11 
                 solute carrier 
                 0.0056 
                 0.6504 
                 −1.5 
               
               
                   
                   
                   
                 family 25 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 carrier; 
                   
                   
                   
               
               
                   
                   
                   
                 oxoglutarate 
                   
                   
                   
               
               
                   
                   
                   
                 carrier), member 
                   
                   
                   
               
               
                   
                   
                   
                 11 
                   
                   
                   
               
               
                 202556_s_at 
                 NM_006337 
                 MCRS1 
                 microspherule 
                 0.0042 
                 0.1233 
                 −1.5 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 205512_s_at 
                 NM_004208 
                 AIFM1 
                 apoptosis-inducing 
                 0.0035 
                 0.7462 
                 −1.5 
               
               
                   
                   
                   
                 factor, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrion- 
                   
                   
                   
               
               
                   
                   
                   
                 associated, 1 
                   
                   
                   
               
               
                 206510_at 
                 AF332197 
                 SIX2 
                 sine oculis 
                 0.0060 
                 0.4870 
                 −1.5 
               
               
                   
                   
                   
                 homeobox 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 2 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 210574_s_at 
                 AF241788 
                 NUDC 
                 nuclear distribution 
                 0.0006 
                 0.1606 
                 −1.5 
               
               
                   
                   
                   
                 gene C homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( A. nidulans ) 
                   
                   
                   
               
               
                 204695_at 
                 AI343459 
                 CDC25A 
                 cell division cycle 
                 0.0011 
                 0.1847 
                 −1.5 
               
               
                   
                   
                   
                 25 homolog A ( S. cerevisiae ) 
                   
                   
                   
               
               
                 200655_s_at 
                 NM_006888 
                 CALM1 
                 calmodulin 1 
                 0.0008 
                 0.0712 
                 −1.5 
               
               
                   
                   
                   
                 (phosphorylase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase, delta) 
                   
                   
                   
               
               
                 202939_at 
                 NM_005857 
                 ZMPSTE24 
                 zinc 
                 0.0088 
                 0.1153 
                 −1.5 
               
               
                   
                   
                   
                 metallopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 (STE24 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 203606_at 
                 NM_004553 
                 NDUFS6 
                 NADH 
                 0.0014 
                 0.0990 
                 −1.5 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) Fe—S 
                   
                   
                   
               
               
                   
                   
                   
                 protein 6, 13 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (NADH-coenzyme 
                   
                   
                   
               
               
                   
                   
                   
                 Q reductase) 
                   
                   
                   
               
               
                 218803_at 
                 NM_018223 
                 CHFR 
                 checkpoint with 
                 0.0040 
                 0.2666 
                 −1.5 
               
               
                   
                   
                   
                 forkhead and ring 
                   
                   
                   
               
               
                   
                   
                   
                 finger domains 
                   
                   
                   
               
               
                 209645_s_at 
                 NM_000692 
                 ALDH1B1 
                 aldehyde 
                 0.0026 
                 0.6355 
                 −1.5 
               
               
                   
                   
                   
                 dehydrogenase 1 
                   
                   
                   
               
               
                   
                   
                   
                 family, member B1 
                   
                   
                   
               
               
                 218893_at 
                 NM_024710 
                 ISOC2 
                 isochorismatase 
                 0.0057 
                 0.1709 
                 −1.5 
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 201192_s_at 
                 NM_006224 
                 PITPNA 
                 phosphatidylinositol 
                 0.0249 
                 0.9184 
                 −1.5 
               
               
                   
                   
                   
                 transfer protein, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 201478_s_at 
                 U59151 
                 DKC1 
                 dyskeratosis 
                 0.0035 
                 0.5159 
                 −1.5 
               
               
                   
                   
                   
                 congenita 1, 
                   
                   
                   
               
               
                   
                   
                   
                 dyskerin 
                   
                   
                   
               
               
                 201020_at 
                 NM_003405 
                 YWHAH 
                 tyrosine 3- 
                 0.0119 
                 0.2666 
                 −1.5 
               
               
                   
                   
                   
                 monooxygenase/tryptophan 
                   
                   
                   
               
               
                   
                   
                   
                 5- 
                   
                   
                   
               
               
                   
                   
                   
                 monooxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 activation protein, 
                   
                   
                   
               
               
                   
                   
                   
                 eta polypeptide 
                   
                   
                   
               
               
                 217785_s_at 
                 NM_006555 
                 YKT6 
                 YKT6 v-SNARE 
                 0.0025 
                 0.4852 
                 −1.5 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 203239_s_at 
                 NM_014516 
                 CNOT3 
                 CCR4-NOT 
                 0.0144 
                 0.0832 
                 −1.5 
               
               
                   
                   
                   
                 transcription 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 3 
                   
                   
                   
               
               
                 208091_s_at 
                 NM_030796 
                 ECOP 
                 EGFR-coamplified 
                 0.0009 
                 0.0746 
                 −1.5 
               
               
                   
                   
                   
                 and overexpressed 
                   
                   
                   
               
               
                   
                   
                   
                 protein /// EGFR- 
                   
                   
                   
               
               
                   
                   
                   
                 coamplified and 
                   
                   
                   
               
               
                   
                   
                   
                 overexpressed 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 202854_at 
                 NM_000194 
                 HPRT1 
                 hypoxanthine 
                 0.0096 
                 0.1663 
                 −1.5 
               
               
                   
                   
                   
                 phosphoribosyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 1 (Lesch- 
                   
                   
                   
               
               
                   
                   
                   
                 Nyhan syndrome) 
                   
                   
                   
               
               
                 200611_s_at 
                 AB010427 
                 WDR1 
                 WD repeat domain 1 
                 0.0024 
                 0.7179 
                 −1.5 
               
               
                 200634_at 
                 NM_005022 
                 PFN1 
                 profilin 1 
                 0.0007 
                 0.0539 
                 −1.5 
               
               
                 209039_x_at 
                 AF001434 
                 EHD1 
                 EH-domain 
                 0.0057 
                 0.9870 
                 −1.5 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 221731_x_at 
                 BF218922 
                 CSPG2 
                 chondroitin sulfate 
                 0.0043 
                 0.0878 
                 −1.5 
               
               
                   
                   
                   
                 proteoglycan 2 
                   
                   
                   
               
               
                   
                   
                   
                 (versican) 
                   
                   
                   
               
               
                 204364_s_at 
                 BE535746 
                 REEP1 
                 receptor accessory 
                 0.0072 
                 0.1344 
                 −1.5 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 216952_s_at 
                 M94363 
                 LMNB2 
                 lamin B2 
                 0.0011 
                 0.0274 
                 −1.5 
               
               
                 201360_at 
                 NM_000099 
                 CST3 
                 cystatin C (amyloid 
                 0.0010 
                 0.0252 
                 −1.5 
               
               
                   
                   
                   
                 angiopathy and 
                   
                   
                   
               
               
                   
                   
                   
                 cerebral 
                   
                   
                   
               
               
                   
                   
                   
                 hemorrhage) 
                   
                   
                   
               
               
                 201420_s_at 
                 BF975273 
                 WDR77 
                 WD repeat domain 
                 0.0011 
                 0.9108 
                 −1.5 
               
               
                   
                   
                   
                 77 
                   
                   
                   
               
               
                 218214_at 
                 NM_021934 
                 C12orf44 
                 chromosome 12 
                 0.0095 
                 0.9055 
                 −1.5 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 44 
                   
                   
                   
               
               
                 202581_at 
                 NM_005346 
                 HSPA1B 
                 heat shock 70 kDa 
                 0.0185 
                 0.1596 
                 −1.5 
               
               
                   
                   
                   
                 protein 1B 
                   
                   
                   
               
               
                 216733_s_at 
                 X86401 
                 GATM 
                 glycine 
                 0.0199 
                 0.5609 
                 −1.5 
               
               
                   
                   
                   
                 amidinotransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (L-arginine:glycine 
                   
                   
                   
               
               
                   
                   
                   
                 amidinotransferase) 
                   
                   
                   
               
               
                 201801_s_at 
                 AF079117 
                 SLC29A1 
                 solute carrier 
                 0.0140 
                 0.5393 
                 −1.5 
               
               
                   
                   
                   
                 family 29 
                   
                   
                   
               
               
                   
                   
                   
                 (nucleoside 
                   
                   
                   
               
               
                   
                   
                   
                 transporters), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 202138_x_at 
                 NM_006303 
                 JTV1 
                 JTV1 gene 
                 0.0023 
                 0.2414 
                 −1.5 
               
               
                 217791_s_at 
                 NM_002860 
                 ALDH18A1 
                 aldehyde 
                 0.0064 
                 0.7660 
                 −1.5 
               
               
                   
                   
                   
                 dehydrogenase 18 
                   
                   
                   
               
               
                   
                   
                   
                 family, member A1 
                   
                   
                   
               
               
                 208677_s_at 
                 AL550657 
                 BSG 
                 basigin (Ok blood 
                 0.0007 
                 0.0428 
                 −1.5 
               
               
                   
                   
                   
                 group) 
                   
                   
                   
               
               
                 203064_s_at 
                 NM_004514 
                 FOXK2 
                 forkhead box K2 
                 0.0090 
                 0.6618 
                 −1.5 
               
               
                 204042_at 
                 AB020707 
                 WASF3 
                 WAS protein 
                 0.0300 
                 0.4120 
                 −1.5 
               
               
                   
                   
                   
                 family, member 3 
                   
                   
                   
               
               
                 201377_at 
                 NM_014847 
                 UBAP2L 
                 ubiquitin 
                 0.0077 
                 0.3919 
                 −1.5 
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                   
                   
                   
                 2-like 
                   
                   
                   
               
               
                 217977_at 
                 NM_016332 
                 SEPX1 
                 selenoprotein X, 1 
                 0.0012 
                 0.5433 
                 −1.4 
               
               
                 218119_at 
                 NM_006327 
                 TIMM23 
                 translocase of inner 
                 0.0054 
                 0.4659 
                 −1.4 
               
               
                   
                   
                 /// 
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                 LOC653252 
                 membrane 23 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 import inner 
                   
                   
                   
               
               
                   
                   
                   
                 membrane 
                   
                   
                   
               
               
                   
                   
                   
                 translocase subunit 
                   
                   
                   
               
               
                   
                   
                   
                 Tim23 
                   
                   
                   
               
               
                 214121_x_at 
                 AA086229 
                 PDLIM7 
                 PDZ and LIM 
                 0.0029 
                 0.0807 
                 −1.4 
               
               
                   
                   
                   
                 domain 7 (enigma) 
                   
                   
                   
               
               
                 200895_s_at 
                 NM_002014 
                 FKBP4 
                 FK506 binding 
                 0.0037 
                 0.8039 
                 −1.4 
               
               
                   
                   
                   
                 protein 4, 59 kDa 
                   
                   
                   
               
               
                 205436_s_at 
                 NM_002105 
                 H2AFX 
                 H2A histone 
                 0.0004 
                 0.0252 
                 −1.4 
               
               
                   
                   
                   
                 family, member X 
                   
                   
                   
               
               
                 217899_at 
                 NM_017727 
                 FLJ20254 
                 hypothetical 
                 0.0129 
                 0.3602 
                 −1.4 
               
               
                   
                   
                   
                 protein FLJ20254 
                   
                   
                   
               
               
                 204488_at 
                 NM_014908 
                 TMEM15 
                 transmembrane 
                 0.0075 
                 0.6853 
                 −1.4 
               
               
                   
                   
                   
                 protein 15 
                   
                   
                   
               
               
                 217903_at 
                 NM_013403 
                 STRN4 
                 striatin, calmodulin 
                 0.0218 
                 0.1914 
                 −1.4 
               
               
                   
                   
                   
                 binding protein 4 
                   
                   
                   
               
               
                 201645_at 
                 NM_002160 
                 TNC 
                 tenascin C 
                 0.0395 
                 0.3472 
                 −1.4 
               
               
                   
                   
                   
                 (hexabrachion) 
                   
                   
                   
               
               
                 212739_s_at 
                 AL523860 
                 NME4 
                 non-metastatic 
                 0.0015 
                 0.3553 
                 −1.4 
               
               
                   
                   
                   
                 cells 4, protein 
                   
                   
                   
               
               
                   
                   
                   
                 expressed in 
                   
                   
                   
               
               
                 213867_x_at 
                 AA809056 
                 ACTB 
                 actin, beta 
                 0.0010 
                 0.8642 
                 −1.4 
               
               
                 201195_s_at 
                 AB018009 
                 SLC7A5 
                 solute carrier 
                 0.0028 
                 0.1293 
                 −1.4 
               
               
                   
                   
                   
                 family 7 (cationic 
                   
                   
                   
               
               
                   
                   
                   
                 amino acid 
                   
                   
                   
               
               
                   
                   
                   
                 transporter, y+ 
                   
                   
                   
               
               
                   
                   
                   
                 system), member 5 
                   
                   
                   
               
               
                 209100_at 
                 BC001327 
                 IFRD2 
                 interferon-related 
                 0.0050 
                 0.2084 
                 −1.4 
               
               
                   
                   
                   
                 developmental 
                   
                   
                   
               
               
                   
                   
                   
                 regulator 2 
                   
                   
                   
               
               
                 202771_at 
                 NM_014745 
                 FAM38A 
                 family with 
                 0.0031 
                 0.0541 
                 −1.4 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 38, member A 
                   
                   
                   
               
               
                 201523_x_at 
                 BE262760 
                 UBE2N 
                 ubiquitin- 
                 0.0012 
                 0.5131 
                 −1.4 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2N 
                   
                   
                   
               
               
                   
                   
                   
                 (UBC13 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 200846_s_at 
                 NM_002708 
                 PPP1CA 
                 protein 
                 0.0010 
                 0.0395 
                 −1.4 
               
               
                   
                   
                   
                 phosphatase 1, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha isoform 
                   
                   
                   
               
               
                 210010_s_at 
                 U25147 
                 SLC25A1 
                 solute carrier 
                 0.0001 
                 0.0157 
                 −1.4 
               
               
                   
                   
                   
                 family 25 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 carrier; citrate 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 209202_s_at 
                 AF001690 
                 EXTL3 
                 exostoses 
                 0.0264 
                 0.4576 
                 −1.4 
               
               
                   
                   
                   
                 (multiple)-like 3 
                   
                   
                   
               
               
                 201043_s_at 
                 NM_006305 
                 ANP32A 
                 acidic (leucine- 
                 0.0079 
                 0.2051 
                 −1.4 
               
               
                   
                   
                   
                 rich) nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoprotein 32 
                   
                   
                   
               
               
                   
                   
                   
                 family, member A 
                   
                   
                   
               
               
                 210378_s_at 
                 BC004118 
                 SSNA1 
                 Sjogren&#39;s syndrome 
                 0.0007 
                 0.2575 
                 −1.4 
               
               
                   
                   
                   
                 nuclear autoantigen 1 
                   
                   
                   
               
               
                 200824_at 
                 NM_000852 
                 GSTP1 
                 glutathione S- 
                 0.0019 
                 0.0537 
                 −1.4 
               
               
                   
                   
                   
                 transferase pi 
                   
                   
                   
               
               
                 212155_at 
                 AA085748 
                 RNF187 
                 ring finger protein 
                 0.0016 
                 0.1231 
                 −1.4 
               
               
                   
                   
                   
                 187 
                   
                   
                   
               
               
                 213011_s_at 
                 BF116254 
                 TPI1 
                 triosephosphate 
                 0.0039 
                 0.3558 
                 −1.4 
               
               
                   
                   
                   
                 isomerase 1 
                   
                   
                   
               
               
                 209482_at 
                 BC001430 
                 POP7 
                 processing of 
                 0.0014 
                 0.3306 
                 −1.4 
               
               
                   
                   
                   
                 precursor 7, 
                   
                   
                   
               
               
                   
                   
                   
                 ribonuclease P 
                   
                   
                   
               
               
                   
                   
                   
                 subunit ( S. cerevisiae ) 
                   
                   
                   
               
               
                 203258_at 
                 NM_006442 
                 DRAP1 
                 DR1-associated 
                 0.0012 
                 0.3362 
                 −1.4 
               
               
                   
                   
                   
                 protein 1 (negative 
                   
                   
                   
               
               
                   
                   
                   
                 cofactor 2 alpha) 
                   
                   
                   
               
               
                 221637_s_at 
                 BC001434 
                 C11orf48 
                 chromosome 11 
                 0.0173 
                 0.3011 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 48 
                   
                   
                   
               
               
                 200646_s_at 
                 NM_006148 
                 NUCB1 
                 nucleobindin 1 
                 0.0039 
                 0.0452 
                 −1.4 
               
               
                 218308_at 
                 NM_006342 
                 TACC3 
                 transforming, 
                 0.0011 
                 0.4338 
                 −1.4 
               
               
                   
                   
                   
                 acidic coiled-coil 
                   
                   
                   
               
               
                   
                   
                   
                 containing protein 3 
                   
                   
                   
               
               
                 204616_at 
                 NM_006002 
                 UCHL3 
                 ubiquitin carboxyl- 
                 0.0045 
                 0.0432 
                 −1.4 
               
               
                   
                   
                   
                 terminal esterase 
                   
                   
                   
               
               
                   
                   
                   
                 L3 (ubiquitin 
                   
                   
                   
               
               
                   
                   
                   
                 thiolesterase) 
                   
                   
                   
               
               
                 205479_s_at 
                 NM_002658 
                 PLAU 
                 plasminogen 
                 0.0244 
                 0.5956 
                 −1.4 
               
               
                   
                   
                   
                 activator, urokinase 
                   
                   
                   
               
               
                 212432_at 
                 AL542571 
                 GRPEL1 
                 GrpE-like 1, 
                 0.0015 
                 0.4084 
                 −1.4 
               
               
                   
                   
                   
                 mitochondrial ( E. coli ) 
                   
                   
                   
               
               
                 208649_s_at 
                 AF100752 
                 VCP 
                 valosin-containing 
                 0.0035 
                 0.5192 
                 −1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 200952_s_at 
                 AI635187 
                 CCND2 
                 cyclin D2 
                 0.0317 
                 0.1578 
                 −1.4 
               
               
                 208478_s_at 
                 NM_004324 
                 BAX 
                 BCL2-associated X 
                 0.0479 
                 0.9784 
                 −1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 206703_at 
                 NM_000747 
                 CHRNB1 
                 cholinergic 
                 0.0146 
                 0.9472 
                 −1.4 
               
               
                   
                   
                   
                 receptor, nicotinic, 
                   
                   
                   
               
               
                   
                   
                   
                 beta 1 (muscle) 
                   
                   
                   
               
               
                 209825_s_at 
                 BC002906 
                 UCK2 
                 uridine-cytidine 
                 0.0010 
                 0.0941 
                 −1.4 
               
               
                   
                   
                   
                 kinase 2 
                   
                   
                   
               
               
                 216251_s_at 
                 BF965437 
                 TTLL12 
                 tubulin tyrosine 
                 0.0022 
                 0.7692 
                 −1.4 
               
               
                   
                   
                   
                 ligase-like family, 
                   
                   
                   
               
               
                   
                   
                   
                 member 12 
                   
                   
                   
               
               
                 208622_s_at 
                 AA670344 
                 VIL2 
                 villin 2 (ezrin) 
                 0.0323 
                 0.6566 
                 −1.4 
               
               
                 208941_s_at 
                 BC000941 
                 SEPHS1 
                 selenophosphate 
                 0.0013 
                 0.3793 
                 −1.4 
               
               
                   
                   
                   
                 synthetase 1 
                   
                   
                   
               
               
                 209262_s_at 
                 BC002669 
                 NR2F6 
                 nuclear receptor 
                 0.0060 
                 0.3291 
                 −1.4 
               
               
                   
                   
                   
                 subfamily 2, group 
                   
                   
                   
               
               
                   
                   
                   
                 F, member 6 
                   
                   
                   
               
               
                 200600_at 
                 NM_002444 
                 MSN 
                 moesin 
                 0.0025 
                 0.0666 
                 −1.4 
               
               
                 200776_s_at 
                 AL518328 
                 BZW1 /// 
                 basic leucine 
                 0.0085 
                 0.1920 
                 −1.4 
               
               
                   
                   
                 LOC151579 
                 zipper and W2 
                   
                   
                   
               
               
                   
                   
                   
                 domains 1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to basic 
                   
                   
                   
               
               
                   
                   
                   
                 leucine zipper and 
                   
                   
                   
               
               
                   
                   
                   
                 W2 domains 1 
                   
                   
                   
               
               
                 201818_at 
                 NM_024830 
                 AYTL2 
                 acyltransferase like 2 
                 0.0071 
                 0.1235 
                 −1.4 
               
               
                 201082_s_at 
                 NM_004082 
                 DCTN1 
                 dynactin 1 (p150, 
                 0.0118 
                 0.0783 
                 −1.4 
               
               
                   
                   
                   
                 glued homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 
                   Drosophila) 
                 
                   
                   
                   
               
               
                 55081_at 
                 W46406 
                 MICALL 1 
                 MICAL-like 1 
                 0.0054 
                 0.9766 
                 −1.4 
               
               
                 216088_s_at 
                 AL078633 
                 PSMA7 
                 proteasome 
                 0.0014 
                 0.6547 
                 −1.4 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, alpha type, 7 
                   
                   
                   
               
               
                 209231_s_at 
                 AI038068 
                 DCTN5 
                 dynactin 5 (p25) 
                 0.0124 
                 0.9715 
                 −1.4 
               
               
                 200827_at 
                 NM_000302 
                 PLOD1 
                 procollagen-lysine 
                 0.0048 
                 0.0510 
                 −1.4 
               
               
                   
                   
                   
                 1,2-oxoglutarate 
                   
                   
                   
               
               
                   
                   
                   
                 5-dioxygenase 1 
                   
                   
                   
               
               
                 213746_s_at 
                 AW051856 
                 FLNA 
                 filamin A, alpha 
                 0.0207 
                 0.5615 
                 −1.4 
               
               
                   
                   
                   
                 (actin binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 280) 
                   
                   
                   
               
               
                 220949_s_at 
                 NM_024033 
                 C7orf49 
                 chromosome 7 
                 0.0047 
                 0.3132 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 49 
                   
                   
                   
               
               
                 202908_at 
                 NM_006005 
                 WFS1 
                 Wolfram syndrome 
                 0.0099 
                 0.2926 
                 −1.4 
               
               
                   
                   
                   
                 1 (wolframin) 
                   
                   
                   
               
               
                 207714_s_at 
                 NM_004353 
                 SERPINH 1 
                 serpin peptidase 
                 0.0012 
                 0.0512 
                 −1.4 
               
               
                   
                   
                   
                 inhibitor, clade H 
                   
                   
                   
               
               
                   
                   
                   
                 (heat shock protein 
                   
                   
                   
               
               
                   
                   
                   
                 47), member 1, 
                   
                   
                   
               
               
                   
                   
                   
                 (collagen binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1) 
                   
                   
                   
               
               
                 217752_s_at 
                 NM_018235 
                 CNDP2 
                 CNDP dipeptidase 
                 0.0082 
                 0.5146 
                 −1.4 
               
               
                   
                   
                   
                 2 (metallopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 M20 family) 
                   
                   
                   
               
               
                 208744_x_at 
                 BG403660 
                 HSPH1 
                 heat shock 
                 0.0104 
                 0.0536 
                 −1.4 
               
               
                   
                   
                   
                 105 kDa/110 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 202111_at 
                 NM_003040 
                 SLC4A2 
                 solute carrier 
                 0.0037 
                 0.0681 
                 −1.4 
               
               
                   
                   
                   
                 family 4, anion 
                   
                   
                   
               
               
                   
                   
                   
                 exchanger, member 
                   
                   
                   
               
               
                   
                   
                   
                 2 (erythrocyte 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                   
                   
                   
                 band 3-like 1) 
                   
                   
                   
               
               
                 212691_at 
                 AW131863 
                 NUP188 
                 nucleoporin 
                 0.0061 
                 0.3316 
                 −1.4 
               
               
                   
                   
                   
                 188 kDa 
                   
                   
                   
               
               
                 210338_s_at 
                 AB034951 
                 HSPA8 
                 heat shock 70 kDa 
                 0.0019 
                 0.1113 
                 −1.4 
               
               
                   
                   
                   
                 protein 8 
                   
                   
                   
               
               
                 202245_at 
                 AW084510 
                 LSS 
                 lanosterol synthase 
                 0.0219 
                 0.2846 
                 −1.4 
               
               
                   
                   
                   
                 (2,3- 
                   
                   
                   
               
               
                   
                   
                   
                 oxidosqualene- 
                   
                   
                   
               
               
                   
                   
                   
                 lanosterol cyclase) 
                   
                   
                   
               
               
                 201762_s_at 
                 NM_002818 
                 PSME2 
                 proteasome 
                 0.0018 
                 0.1893 
                 −1.4 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 activator subunit 2 
                   
                   
                   
               
               
                   
                   
                   
                 (PA28 beta) 
                   
                   
                   
               
               
                 218815_s_at 
                 NM_018022 
                 TMEM51 
                 transmembrane 
                 0.0079 
                 0.6437 
                 −1.4 
               
               
                   
                   
                   
                 protein 51 
                   
                   
                   
               
               
                 204147_s_at 
                 NM_007111 
                 TFDP1 
                 transcription factor 
                 0.0247 
                 0.6619 
                 −1.4 
               
               
                   
                   
                   
                 Dp-1 
                   
                   
                   
               
               
                 201204_s_at 
                 AA706065 
                 RRBP1 
                 ribosome binding 
                 0.0340 
                 0.7216 
                 −1.4 
               
               
                   
                   
                   
                 protein 1 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 180 kDa (dog) 
                   
                   
                   
               
               
                 50314_i_at 
                 AI761506 
                 C20orf27 
                 chromosome 20 
                 0.0025 
                 0.1143 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 27 
                   
                   
                   
               
               
                 201584_s_at 
                 NM_005804 
                 DDX39 
                 DEAD (Asp-Glu- 
                 0.0024 
                 0.2953 
                 −1.4 
               
               
                   
                   
                   
                 Ala-Asp) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 39 
                   
                   
                   
               
               
                 208928_at 
                 AF258341 
                 POR 
                 P450 (cytochrome) 
                 0.0269 
                 0.3414 
                 −1.4 
               
               
                   
                   
                   
                 oxidoreductase 
                   
                   
                   
               
               
                 220326_s_at 
                 NM_018071 
                 FLJ10357 
                 hypothetical 
                 0.0005 
                 0.0252 
                 −1.4 
               
               
                   
                   
                   
                 protein FLJ10357 
                   
                   
                   
               
               
                 201654_s_at 
                 AI991033 
                 HSPG2 
                 heparan sulfate 
                 0.0045 
                 0.0396 
                 −1.4 
               
               
                   
                   
                   
                 proteoglycan 2 
                   
                   
                   
               
               
                   
                   
                   
                 (perlecan) 
                   
                   
                   
               
               
                 202737_s_at 
                 NM_012321 
                 LSM4 
                 LSM4 homolog, 
                 0.0066 
                 0.6417 
                 −1.4 
               
               
                   
                   
                   
                 U6 small nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 RNA associated ( S. cerevisiae ) 
                   
                   
                   
               
               
                 202528_at 
                 NM_000403 
                 GALE 
                 UDP-galactose-4- 
                 0.0114 
                 0.5096 
                 −1.4 
               
               
                   
                   
                   
                 epimerase 
                   
                   
                   
               
               
                 209652_s_at 
                 BC001422 
                 PGF 
                 placental growth 
                 0.0012 
                 0.0452 
                 −1.4 
               
               
                   
                   
                   
                 factor, vascular 
                   
                   
                   
               
               
                   
                   
                   
                 endothelial growth 
                   
                   
                   
               
               
                   
                   
                   
                 factor-related 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 203270_at 
                 NM_012145 
                 DTYMK 
                 deoxythymidylate 
                 0.0049 
                 0.2176 
                 −1.4 
               
               
                   
                   
                 /// 
                 kinase 
                   
                   
                   
               
               
                   
                   
                 LOC727761 
                 (thymidylate 
                   
                   
                   
               
               
                   
                   
                   
                 kinase) /// similar 
                   
                   
                   
               
               
                   
                   
                   
                 to 
                   
                   
                   
               
               
                   
                   
                   
                 deoxythymidylate 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 
                   
                   
                   
               
               
                   
                   
                   
                 (thymidylate 
                   
                   
                   
               
               
                   
                   
                   
                 kinase) 
                   
                   
                   
               
               
                 218695_at 
                 NM_019037 
                 EXOSC4 
                 exosome 
                 0.0046 
                 0.3295 
                 −1.4 
               
               
                   
                   
                   
                 component 4 
                   
                   
                   
               
               
                 202894_at 
                 NM_004444 
                 EPHB4 
                 EPH receptor B4 
                 0.0057 
                 0.6685 
                 −1.4 
               
               
                 200700_s_at 
                 NM_006854 
                 KDELR2 
                 KDEL (Lys-Asp- 
                 0.0021 
                 0.3528 
                 −1.4 
               
               
                   
                   
                   
                 Glu-Leu) 
                   
                   
                   
               
               
                   
                   
                   
                 endoplasmic 
                   
                   
                   
               
               
                   
                   
                   
                 reticulum protein 
                   
                   
                   
               
               
                   
                   
                   
                 retention receptor 2 
                   
                   
                   
               
               
                 219526_at 
                 NM_024644 
                 C14orf169 
                 chromosome 14 
                 0.0075 
                 0.3181 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 169 
                   
                   
                   
               
               
                 209052_s_at 
                 BF111870 
                 WHSC1 
                 Wolf-Hirschhorn 
                 0.0039 
                 0.0436 
                 −1.4 
               
               
                   
                   
                   
                 syndrome 
                   
                   
                   
               
               
                   
                   
                   
                 candidate 1 
                   
                   
                   
               
               
                 201282_at 
                 NM_002541 
                 OGDH 
                 oxoglutarate 
                 0.0117 
                 0.0916 
                 −1.4 
               
               
                   
                   
                   
                 (alpha- 
                   
                   
                   
               
               
                   
                   
                   
                 ketoglutarate) 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (lipoamide) 
                   
                   
                   
               
               
                 221484_at 
                 BF691447 
                 B4GALT5 
                 UDP- 
                 0.0078 
                 0.4685 
                 −1.4 
               
               
                   
                   
                   
                 Gal:betaGlcNAc 
                   
                   
                   
               
               
                   
                   
                   
                 beta 1,4- 
                   
                   
                   
               
               
                   
                   
                   
                 galactosyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 5 
                   
                   
                   
               
               
                 200911_s_at 
                 NM_006283 
                 TACC1 
                 transforming, 
                 0.0036 
                 0.1542 
                 −1.4 
               
               
                   
                   
                   
                 acidic coiled-coil 
                   
                   
                   
               
               
                   
                   
                   
                 containing protein 1 
                   
                   
                   
               
               
                 203039_s_at 
                 NM_005006 
                 NDUFS1 
                 NAPH 
                 0.0159 
                 0.2193 
                 −1.4 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) Fe—S 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1, 75 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (NADH-coenzyme 
                   
                   
                   
               
               
                   
                   
                   
                 Q reductase) 
                   
                   
                   
               
               
                 201168_x_at 
                 NM_004309 
                 ARHGDIA 
                 Rho GDP 
                 0.0007 
                 0.0451 
                 −1.4 
               
               
                   
                   
                 /// 
                 dissociation 
                   
                   
                   
               
               
                   
                   
                 LOC728908 
                 inhibitor (GDI) 
                   
                   
                   
               
               
                   
                   
                   
                 alpha /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Rho GDP 
                   
                   
                   
               
               
                   
                   
                   
                 dissociation 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor (GDI) 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 201537_s_at 
                 BC002682 
                 DUSP3 
                 dual specificity 
                 0.0061 
                 0.1488 
                 −1.4 
               
               
                   
                   
                   
                 phosphatase 3 
                   
                   
                   
               
               
                   
                   
                   
                 (vaccinia virus 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatase VH1- 
                   
                   
                   
               
               
                   
                   
                   
                 related) 
                   
                   
                   
               
               
                 209773_s_at 
                 BC001886 
                 RRM2 
                 ribonucleotide 
                 0.0007 
                 0.2822 
                 −1.4 
               
               
                   
                   
                   
                 reductase M2 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 
                   
                   
                   
               
               
                 210986_s_at 
                 Z24727 
                 TPM1 
                 tropomyosin 1 
                 0.0436 
                 0.6520 
                 −1.4 
               
               
                   
                   
                   
                 (alpha) 
                   
                   
                   
               
               
                 218493_at 
                 NM_024571 
                 C16orf33 
                 chromosome 16 
                 0.0022 
                 0.5112 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 33 
                   
                   
                   
               
               
                 202887_s_at 
                 NM_019058 
                 DDIT4 
                 DNA-damage- 
                 0.0039 
                 0.1757 
                 −1.4 
               
               
                   
                   
                   
                 inducible transcript 4 
                   
                   
                   
               
               
                 218857_s_at 
                 NM_025080 
                 ASRGL1 
                 asparaginase like 1 
                 0.0047 
                 0.6967 
                 −1.4 
               
               
                 209190_s_at 
                 AF051782 
                 DIAPH1 
                 diaphanous 
                 0.0057 
                 0.6058 
                 −1.4 
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 200650_s_at 
                 NM_005566 
                 LDHA 
                 lactate 
                 0.0004 
                 0.0344 
                 −1.4 
               
               
                   
                   
                   
                 dehydrogenase A 
                   
                   
                   
               
               
                 200948_at 
                 NM_005439 
                 MLF2 
                 myeloid leukemia 
                 0.0078 
                 0.3850 
                 −1.4 
               
               
                   
                   
                   
                 factor 2 
                   
                   
                   
               
               
                 200623_s_at 
                 NM_005184 
                 CALM3 
                 calmodulin 3 
                 0.0079 
                 0.0721 
                 −1.4 
               
               
                   
                   
                   
                 (phosphorylase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase, delta) 
                   
                   
                   
               
               
                 204849_at 
                 NM_006602 
                 TCFL5 
                 transcription 
                 0.0088 
                 0.7035 
                 −1.4 
               
               
                   
                   
                   
                 factor-like 5 (basic 
                   
                   
                   
               
               
                   
                   
                   
                 helix-loop-helix) 
                   
                   
                   
               
               
                 204331_s_at 
                 NM_021107 
                 MRPS12 
                 mitochondrial 
                 0.0060 
                 0.5066 
                 −1.4 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S12 
                   
                   
                   
               
               
                 213476_x_at 
                 AL565749 
                 TUBB3 
                 tubulin beta 3 
                 0.0076 
                 0.7836 
                 −1.4 
               
               
                 209321_s_at 
                 AF033861 
                 ADCY3 
                 adenylate cyclase 3 
                 0.0034 
                 0.0856 
                 −1.4 
               
               
                 200808_s_at 
                 NM_003461 
                 ZYX 
                 zyxin 
                 0.0061 
                 0.4333 
                 −1.4 
               
               
                 219212_at 
                 NM_016299 
                 HSPA14 
                 heat shock 70 kDa 
                 0.0027 
                 0.1403 
                 −1.4 
               
               
                   
                   
                   
                 protein 14 
                   
                   
                   
               
               
                 206593_s_at 
                 NM_006752 
                 SURF5 
                 surfeit 5 
                 0.0363 
                 0.2712 
                 −1.4 
               
               
                 201797_s_at 
                 NM_006295 
                 VARS 
                 valyl-tRNA 
                 0.0159 
                 0.9226 
                 −1.4 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 203190_at 
                 NM_002496 
                 NDUFS8 
                 NADH 
                 0.0019 
                 0.8311 
                 −1.4 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) Fe—S 
                   
                   
                   
               
               
                   
                   
                   
                 protein 8, 23 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (NADH-coenzyme 
                   
                   
                   
               
               
                   
                   
                   
                 Q reductase) 
                   
                   
                   
               
               
                 2028_s_at 
                 M96577 
                 E2F1 
                 E2F transcription 
                 0.0227 
                 0.5305 
                 −1.4 
               
               
                   
                   
                   
                 factor 1 
                   
                   
                   
               
               
                 203392_s_at 
                 NM_001328 
                 CTBP1 
                 C-terminal binding 
                 0.0091 
                 0.7822 
                 −1.4 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 217818_s_at 
                 NM_005718 
                 ARPC4 
                 actin related 
                 0.0112 
                 0.4886 
                 −1.4 
               
               
                   
                   
                   
                 protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 4, 
                   
                   
                   
               
               
                   
                   
                   
                 20 kDa 
                   
                   
                   
               
               
                 208657_s_at 
                 AF142408 
                 9-Sep 
                 septin 9 
                 0.0041 
                 0.0721 
                 −1.4 
               
               
                 201252_at 
                 NM_006503 
                 PSMC4 /// 
                 proteasome 
                 0.0034 
                 0.2890 
                 −1.4 
               
               
                   
                   
                 LOC652826 
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, ATPase, 4 
                   
                   
                   
               
               
                   
                   
                   
                 /// similar to 26S 
                   
                   
                   
               
               
                   
                   
                   
                 protease regulatory 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 6B 
                   
                   
                   
               
               
                   
                   
                   
                 (MIP224) (MB67- 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein) 
                   
                   
                   
               
               
                   
                   
                   
                 (TAT-binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 7) (TBP-7) 
                   
                   
                   
               
               
                 200880_at 
                 AL534104 
                 DNAJA1 
                 DnaJ (Hsp40) 
                 0.0122 
                 0.1190 
                 −1.4 
               
               
                   
                   
                   
                 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily A, 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 201573_s_at 
                 M75715 
                 ETF1 
                 eukaryotic 
                 0.0065 
                 0.4236 
                 −1.4 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 termination factor 1 
                   
                   
                   
               
               
                 218131_s_at 
                 NM_017660 
                 GATAD2A 
                 GATA zinc finger 
                 0.0045 
                 0.1527 
                 −1.4 
               
               
                   
                   
                   
                 domain containing 
                   
                   
                   
               
               
                   
                   
                   
                 2A 
                   
                   
                   
               
               
                 207740_s_at 
                 NM_012346 
                 NUP62 
                 nucleoporin 62 kDa 
                 0.0302 
                 0.2490 
                 −1.4 
               
               
                 217777_s_at 
                 NM_016395 
                 PTPLAD1 
                 protein tyrosine 
                 0.0237 
                 0.3399 
                 −1.4 
               
               
                   
                   
                 /// 
                 phosphatase-like A 
                   
                   
                   
               
               
                   
                   
                 LOC732402 
                 domain containing 
                   
                   
                   
               
               
                   
                   
                   
                 1 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 butyrate-induced 
                   
                   
                   
               
               
                   
                   
                   
                 transcript 1 
                   
                   
                   
               
               
                 218474_s_at 
                 NM_018992 
                 KCTD5 
                 potassium channel 
                 0.0314 
                 0.5788 
                 −1.4 
               
               
                   
                   
                   
                 tetramerisation 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 5 
                   
                   
                   
               
               
                 200621_at 
                 NM_004078 
                 CSRP1 
                 cysteine and 
                 0.0007 
                 0.1464 
                 −1.4 
               
               
                   
                   
                   
                 glycine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 219438_at 
                 NM_024522 
                 FAM77C 
                 family with 
                 0.0279 
                 0.9563 
                 −1.4 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 77, member C 
                   
                   
                   
               
               
                 211070_x_at 
                 BC006466 
                 DBI 
                 diazepam binding 
                 0.0029 
                 0.0800 
                 −1.4 
               
               
                   
                   
                   
                 inhibitor (GABA 
                   
                   
                   
               
               
                   
                   
                   
                 receptor modulator, 
                   
                   
                   
               
               
                   
                   
                   
                 acyl-Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein) /// 
                   
                   
                   
               
               
                   
                   
                   
                 diazepam binding 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor (GABA 
                   
                   
                   
               
               
                   
                   
                   
                 receptor modulator, 
                   
                   
                   
               
               
                   
                   
                   
                 acyl-Coenzyme A 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein) 
                   
                   
                   
               
               
                 212378_at 
                 NM_000819 
                 GART 
                 phosphoribosylglycinamide 
                 0.0046 
                 0.4656 
                 −1.4 
               
               
                   
                   
                   
                 formyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoribosylglycinamide 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase, 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoribosylaminoimidazole 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 208453_s_at 
                 NM_006523 
                 XPNPEP1 
                 X-prolyl 
                 0.0102 
                 0.6642 
                 −1.4 
               
               
                   
                   
                   
                 aminopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 (aminopeptidase P) 
                   
                   
                   
               
               
                   
                   
                   
                 1, soluble 
                   
                   
                   
               
               
                 203489_at 
                 NM_006427 
                 SIVA1 
                 SIVA1, apoptosis- 
                 0.0054 
                 0.3864 
                 −1.4 
               
               
                   
                   
                   
                 inducing factor 
                   
                   
                   
               
               
                 209834_at 
                 AB017915 
                 CHST3 
                 carbohydrate 
                 0.0107 
                 0.4595 
                 −1.4 
               
               
                   
                   
                   
                 (chondroitin 6) 
                   
                   
                   
               
               
                   
                   
                   
                 sulfotransferase 3 
                   
                   
                   
               
               
                 208700_s_at 
                 L12711 
                 TKT 
                 transketolase 
                 0.0008 
                 0.0502 
                 −1.4 
               
               
                   
                   
                   
                 (Wernicke- 
                   
                   
                   
               
               
                   
                   
                   
                 Korsakoff 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome) 
                   
                   
                   
               
               
                 202595_s_at 
                 AF161461 
                 LEPROTL1 
                 leptin receptor 
                 0.0451 
                 0.8984 
                 −1.4 
               
               
                   
                   
                   
                 overlapping 
                   
                   
                   
               
               
                   
                   
                   
                 transcript-like 1 
                   
                   
                   
               
               
                 203252_at 
                 NM_005851 
                 CDK2AP2 
                 CDK2-associated 
                 0.0302 
                 0.6607 
                 −1.4 
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 205895_s_at 
                 NM_004741 
                 NOLC1 
                 nucleolar and 
                 0.0243 
                 0.5497 
                 −1.4 
               
               
                   
                   
                   
                 coiled-body 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoprotein 1 
                   
                   
                   
               
               
                 201979_s_at 
                 NM_006247 
                 PPP5C 
                 protein 
                 0.0271 
                 0.1164 
                 −1.4 
               
               
                   
                   
                   
                 phosphatase 5, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit 
                   
                   
                   
               
               
                 208313_s_at 
                 NM_004630 
                 SF1 
                 splicing factor 1 
                 0.0012 
                 0.0284 
                 −1.4 
               
               
                 203814_s_at 
                 NM_000904 
                 NQO2 
                 NAD(P)H 
                 0.0332 
                 0.6539 
                 −1.4 
               
               
                   
                   
                   
                 dehydrogenase, 
                   
                   
                   
               
               
                   
                   
                   
                 quinone 2 
                   
                   
                   
               
               
                 217294_s_at 
                 U88968 
                 ENO1 
                 enolase 1, (alpha) 
                 0.0080 
                 0.5283 
                 −1.4 
               
               
                 201714_at 
                 NM_001070 
                 TUBG1 
                 tubulin, gamma 1 
                 0.0049 
                 0.9428 
                 −1.4 
               
               
                 212116_at 
                 NM_006510 
                 TRIM27 
                 tripartite motif- 
                 0.0042 
                 0.3418 
                 −1.4 
               
               
                   
                   
                   
                 containing 27 
                   
                   
                   
               
               
                 218744_s_at 
                 NM_016223 
                 PACSIN3 
                 protein kinase C 
                 0.0054 
                 0.8147 
                 −1.4 
               
               
                   
                   
                   
                 and casein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 substrate in 
                   
                   
                   
               
               
                   
                   
                   
                 neurons 3 
                   
                   
                   
               
               
                 201090_x_at 
                 NM_006082 
                 K- 
                 alpha tubulin 
                 0.0014 
                 0.1096 
                 −1.4 
               
               
                   
                   
                 ALPHA-1 
                   
                   
                   
                   
               
               
                 219361_s_at 
                 NM_022767 
                 ISG20L1 
                 interferon 
                 0.0012 
                 0.0579 
                 −1.4 
               
               
                   
                   
                   
                 stimulated 
                   
                   
                   
               
               
                   
                   
                   
                 exonuclease gene 
                   
                   
                   
               
               
                   
                   
                   
                 20 kDa-like 1 
                   
                   
                   
               
               
                 211126_s_at 
                 U46006 
                 CSRP2 
                 cysteine and 
                 0.0007 
                 0.0582 
                 −1.4 
               
               
                   
                   
                   
                 glycine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 202329_at 
                 NM_004383 
                 CSK 
                 c-src tyrosine 
                 0.0222 
                 0.8338 
                 −1.4 
               
               
                   
                   
                   
                 kinase 
                   
                   
                   
               
               
                 212712_at 
                 BE222901 
                 CAMSAP1 
                 calmodulin 
                 0.0064 
                 0.4040 
                 −1.4 
               
               
                   
                   
                   
                 regulated spectrin- 
                   
                   
                   
               
               
                   
                   
                   
                 associated protein 1 
                   
                   
                   
               
               
                 202483_s_at 
                 NM_002882 
                 RANBP1 
                 RAN binding 
                 0.0020 
                 0.0727 
                 −1.4 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 201368_at 
                 U07802 
                 ZFP36L2 
                 zinc finger protein 
                 0.0165 
                 0.2538 
                 −1.4 
               
               
                   
                   
                   
                 36, C3H type-like 2 
                   
                   
                   
               
               
                 209526_s_at 
                 AB029156 
                 HDGFRP3 
                 hepatoma-derived 
                 0.0034 
                 0.2976 
                 −1.4 
               
               
                   
                   
                   
                 growth factor, 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 3 
                   
                   
                   
               
               
                 202407_s_at 
                 BF342707 
                 PRPF31 
                 PRP31 pre-mRNA 
                 0.0144 
                 0.1019 
                 −1.4 
               
               
                   
                   
                   
                 processing factor 
                   
                   
                   
               
               
                   
                   
                   
                 31 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 212126_at 
                 BG391282 
                 — 
                 CDNA clone 
                 0.0066 
                 0.0714 
                 −1.4 
               
               
                   
                   
                   
                 IMAGE: 4842353 
                   
                   
                   
               
               
                 202779_s_at 
                 NM_014501 
                 UBE2S /// 
                 ubiquitin- 
                 0.0007 
                 0.0841 
                 −1.4 
               
               
                   
                   
                 LOC731049 
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2S /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Ubiquitin- 
                   
                   
                   
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2S 
                   
                   
                   
               
               
                   
                   
                   
                 (Ubiquitin- 
                   
                   
                   
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2-24 kDa) 
                   
                   
                   
               
               
                   
                   
                   
                 (Ubiquitin- 
                   
                   
                   
               
               
                   
                   
                   
                 protein ligase) 
                   
                   
                   
               
               
                   
                   
                   
                 (Ubiquitin carrier 
                   
                   
                   
               
               
                   
                   
                   
                 protein) (E2-EPF5) 
                   
                   
                   
               
               
                 211593_s_at 
                 AB047005 
                 MAST2 
                 microtubule 
                 0.0061 
                 0.1211 
                 −1.4 
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 serine/threonine 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 2 /// 
                   
                   
                   
               
               
                   
                   
                   
                 microtubule 
                   
                   
                   
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 serine/threonine 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 2 
                   
                   
                   
               
               
                 213787_s_at 
                 AV702405 
                 EBP 
                 emopamil binding 
                 0.0414 
                 0.3058 
                 −1.4 
               
               
                   
                   
                   
                 protein (sterol 
                   
                   
                   
               
               
                   
                   
                   
                 isomerase) 
                   
                   
                   
               
               
                 217796_s_at 
                 NM_017921 
                 NPLOC4 
                 nuclear protein 
                 0.0069 
                 0.2545 
                 −1.4 
               
               
                   
                   
                   
                 localization 4 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 214507_s_at 
                 NM_014285 
                 EXOSC2 
                 exosome 
                 0.0023 
                 0.4634 
                 −1.4 
               
               
                   
                   
                   
                 component 2 
                   
                   
                   
               
               
                 209233_at 
                 U72514 
                 EMG1 
                 EMG1 nucleolar 
                 0.0052 
                 0.4127 
                 −1.4 
               
               
                   
                   
                   
                 protein homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 221759_at 
                 AL583123 
                 G6PC3 
                 glucose 6 
                 0.0069 
                 0.0941 
                 −1.4 
               
               
                   
                   
                   
                 phosphatase, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic, 3 
                   
                   
                   
               
               
                 215121_x_at 
                 AA680302 
                 IGL@ /// 
                 immunoglobulin 
                 0.0302 
                 0.3171 
                 −1.4 
               
               
                   
                   
                 IGLV4-3 
                 lambda locus /// 
                   
                   
                   
               
               
                   
                   
                 /// IGLV3- 
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                 25 /// 
                 lambda variable 4- 
                   
                   
                   
               
               
                   
                   
                 IGLV2-14 
                 3 /// 
                   
                   
                   
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 lambda variable 3- 
                   
                   
                   
               
               
                   
                   
                   
                 25 /// 
                   
                   
                   
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 lambda variable 2- 
                   
                   
                   
               
               
                   
                   
                   
                 14 
                   
                   
                   
               
               
                 210026_s_at 
                 AY028896 
                 CARD10 
                 caspase 
                 0.0193 
                 0.7762 
                 −1.4 
               
               
                   
                   
                   
                 recruitment domain 
                   
                   
                   
               
               
                   
                   
                   
                 family, member 10 
                   
                   
                   
               
               
                 211762_s_at 
                 BC005978 
                 KPNA2 /// 
                 karyopherin alpha 
                 0.0066 
                 0.4069 
                 −1.4 
               
               
                   
                   
                 LOC728860 
                 2 (RAG cohort 1, 
                   
                   
                   
               
               
                   
                   
                   
                 importin alpha 1) 
                   
                   
                   
               
               
                   
                   
                   
                 /// karyopherin 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 2 (RAG 
                   
                   
                   
               
               
                   
                   
                   
                 cohort 1, importin 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 1) /// similar 
                   
                   
                   
               
               
                   
                   
                   
                 to Importin alpha-2 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                   
                   
                   
                 (Karyopherin 
                   
                   
                   
               
               
                   
                   
                   
                 alpha-2 subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (SRP1-alpha) 
                   
                   
                   
               
               
                   
                   
                   
                 (RAG cohort 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1) /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to Importin 
                   
                   
                   
               
               
                   
                   
                   
                 alpha-2 subunit 
                   
                   
                   
               
               
                   
                   
                   
                 (Karyopherin 
                   
                   
                   
               
               
                   
                   
                   
                 alpha-2 subunit) 
                   
                   
                   
               
               
                   
                   
                   
                 (SRP1-alpha) 
                   
                   
                   
               
               
                   
                   
                   
                 (RAG cohort 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1) 
                   
                   
                   
               
               
                 218678_at 
                 NM_024609 
                 NES 
                 nestin 
                 0.0043 
                 0.1063 
                 −1.4 
               
               
                 201275_at 
                 NM_002004 
                 FDPS 
                 farnesyl 
                 0.0014 
                 0.9609 
                 −1.4 
               
               
                   
                   
                   
                 diphosphate 
                   
                   
                   
               
               
                   
                   
                   
                 synthase (farnesyl 
                   
                   
                   
               
               
                   
                   
                   
                 pyrophosphate 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase, 
                   
                   
                   
               
               
                   
                   
                   
                 dimethylallyltranstransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 geranyltranstransferase) 
                   
                   
                   
               
               
                 220011_at 
                 NM_024037 
                 C1orf135 
                 chromosome 1 
                 0.0050 
                 0.1904 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 135 
                   
                   
                   
               
               
                 201000_at 
                 NM_001605 
                 AARS 
                 alanyl-tRNA 
                 0.0076 
                 0.6685 
                 −1.4 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 217835_x_at 
                 NM_018840 
                 C20orf24 
                 chromosome 20 
                 0.0011 
                 0.0271 
                 −1.4 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 24 
                   
                   
                   
               
               
                 217755_at 
                 NM_016185 
                 HN1 
                 hematological and 
                 0.0007 
                 0.0336 
                 −1.4 
               
               
                   
                   
                   
                 neurological 
                   
                   
                   
               
               
                   
                   
                   
                 expressed 1 
                   
                   
                   
               
               
                 200734_s_at 
                 BG341906 
                 ARF3 
                 ADP-ribosylation 
                 0.0093 
                 0.2784 
                 −1.4 
               
               
                   
                   
                   
                 factor 3 
                   
                   
                   
               
               
                 203411_s_at 
                 NM_005572 
                 LMNA 
                 lamin A/C 
                 0.0007 
                 0.1514 
                 −1.4 
               
               
                 218661_at 
                 NM_024845 
                 FLJ14154 
                 hypothetical 
                 0.0066 
                 0.3772 
                 −1.4 
               
               
                   
                   
                   
                 protein FLJ14154 
                   
                   
                   
               
               
                 214439_x_at 
                 AF043899 
                 BIN1 
                 bridging integrator 1 
                 0.0130 
                 0.4300 
                 −1.4 
               
               
                 201953_at 
                 NM_006384 
                 CIB1 
                 calcium and 
                 0.0078 
                 0.1914 
                 −1.4 
               
               
                   
                   
                   
                 integrin binding 1 
                   
                   
                   
               
               
                   
                   
                   
                 (calmyrin) 
                   
                   
                   
               
               
                 208540_x_at 
                 NM_021039 
                 LOC729659 
                 similar to Putative 
                 0.0057 
                 0.3193 
                 −1.4 
               
               
                   
                   
                 /// 
                 S100 calcium- 
                   
                   
                   
               
               
                   
                   
                 LOC730278 
                 binding protein 
                   
                   
                   
               
               
                   
                   
                 /// 
                 A11 pseudogene /// 
                   
                   
                   
               
               
                   
                   
                 LOC730558 
                 similar to Putative 
                   
                   
                   
               
               
                   
                   
                   
                 S100 calcium- 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 A11 pseudogene /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to Putative 
                   
                   
                   
               
               
                   
                   
                   
                 S100 calcium- 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 A11 pseudogene 
                   
                   
                   
               
               
                 202718_at 
                 NM_000597 
                 IGFBP2 
                 insulin-like growth 
                 0.0007 
                 0.0157 
                 −1.4 
               
               
                   
                   
                   
                 factor binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2, 36 kDa 
                   
                   
                   
               
               
                 209567_at 
                 BC001811 
                 RRS1 
                 RRS1 ribosome 
                 0.0265 
                 0.1269 
                 −1.4 
               
               
                   
                   
                   
                 biogenesis 
                   
                   
                   
               
               
                   
                   
                   
                 regulator homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 212540_at 
                 BG476661 
                 CDC34 
                 cell division cycle 
                 0.0110 
                 0.9118 
                 −1.4 
               
               
                   
                   
                   
                 34 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 213470_s_at 
                 BF983406 
                 HNRPH1 
                 heterogeneous 
                 0.0175 
                 0.5096 
                 −1.4 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 H1 (H) 
                   
                   
                   
               
               
                 200964_at 
                 NM_003334 
                 UBE1 
                 ubiquitin- 
                 0.0009 
                 0.0599 
                 −1.4 
               
               
                   
                   
                   
                 activating enzyme 
                   
                   
                   
               
               
                   
                   
                   
                 E1 (A1S9T and 
                   
                   
                   
               
               
                   
                   
                   
                 BN75 temperature 
                   
                   
                   
               
               
                   
                   
                   
                 sensitivity 
                   
                   
                   
               
               
                   
                   
                   
                 complementing) 
                   
                   
                   
               
               
                 221571_at 
                 AI721219 
                 TRAF3 
                 TNF receptor- 
                 0.0065 
                 0.1689 
                 −1.4 
               
               
                   
                   
                   
                 associated factor 3 
                   
                   
                   
               
               
                 201096_s_at 
                 AL537042 
                 ARF4 
                 ADP-ribosylation 
                 0.0093 
                 0.3651 
                 −1.4 
               
               
                   
                   
                   
                 factor 4 
                   
                   
                   
               
               
                 215714_s_at 
                 AF254822 
                 SMARCA4 
                 SWI/SNF related, 
                 0.0135 
                 0.1898 
                 −1.4 
               
               
                   
                   
                   
                 matrix associated, 
                   
                   
                   
               
               
                   
                   
                   
                 actin dependent 
                   
                   
                   
               
               
                   
                   
                   
                 regulator of 
                   
                   
                   
               
               
                   
                   
                   
                 chromatin, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily a, 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 
                   
                   
                   
               
               
                 202469_s_at 
                 AU149367 
                 CPSF6 
                 cleavage and 
                 0.0399 
                 0.2918 
                 −1.4 
               
               
                   
                   
                   
                 polyadenylation 
                   
                   
                   
               
               
                   
                   
                   
                 specific factor 6, 
                   
                   
                   
               
               
                   
                   
                   
                 68 kDa 
                   
                   
                   
               
               
                 65585_at 
                 AA527515 
                 FAM86B1 
                 family with 
                 0.0044 
                 0.0891 
                 −1.4 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 86, member B1 
                   
                   
                   
               
               
                 213334_x_at 
                 BE676218 
                 UCHL5IP 
                 UCHL5 interacting 
                 0.0136 
                 0.5765 
                 −1.4 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 209213_at 
                 BC002511 
                 CBR1 
                 carbonyl reductase 1 
                 0.0080 
                 0.9371 
                 −1.4 
               
               
                 206441_s_at 
                 NM_017828 
                 COMMD4 
                 COMM domain 
                 0.0069 
                 0.0965 
                 −1.4 
               
               
                   
                   
                   
                 containing 4 
                   
                   
                   
               
               
                 218650_at 
                 NM_022775 
                 DGCR8 
                 DiGeorge 
                 0.0166 
                 0.0645 
                 −1.4 
               
               
                   
                   
                   
                 syndrome critical 
                   
                   
                   
               
               
                   
                   
                   
                 region gene 8 
                   
                   
                   
               
               
                 218200_s_at 
                 NM_004546 
                 NDUFB2 
                 NADH 
                 0.0026 
                 0.3329 
                 −1.4 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) 1 beta 
                   
                   
                   
               
               
                   
                   
                   
                 subcomplex, 2, 
                   
                   
                   
               
               
                   
                   
                   
                 8 kDa 
                   
                   
                   
               
               
                 202692_s_at 
                 NM_014233 
                 UBTF 
                 upstream binding 
                 0.0074 
                 0.4143 
                 −1.4 
               
               
                   
                   
                   
                 transcription factor, 
                   
                   
                   
               
               
                   
                   
                   
                 RNA polymerase I 
                   
                   
                   
               
               
                 201247_at 
                 BE513151 
                 — 
                 — 
                 0.0042 
                 0.0441 
                 −1.4 
               
               
                 208308_s_at 
                 NM_000175 
                 GPI 
                 glucose phosphate 
                 0.0014 
                 0.0589 
                 −1.4 
               
               
                   
                   
                   
                 isomerase 
                   
                   
                   
               
               
                 218028_at 
                 NM_016031 
                 ELOVL1 
                 elongation of very 
                 0.0052 
                 0.1335 
                 −1.4 
               
               
                   
                   
                   
                 long chain fatty 
                   
                   
                   
               
               
                   
                   
                   
                 acids (FEN1/Elo2, 
                   
                   
                   
               
               
                   
                   
                   
                 SUR4/Elo3, yeast)- 
                   
                   
                   
               
               
                   
                   
                   
                 like 1 
                   
                   
                   
               
               
                 204955_at 
                 NM_006307 
                 SRPX 
                 sushi-repeat- 
                 0.0149 
                 0.0681 
                 −1.4 
               
               
                   
                   
                   
                 containing protein, 
                   
                   
                   
               
               
                   
                   
                   
                 X-linked 
                   
                   
                   
               
               
                 201543_s_at 
                 NM_020150 
                 SAR1A 
                 SAR1 gene 
                 0.0017 
                 0.1483 
                 −1.4 
               
               
                   
                   
                   
                 homolog A ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209093_s_at 
                 K02920 
                 GBA /// 
                 glucosidase, beta; 
                 0.0066 
                 0.1233 
                 −1.4 
               
               
                   
                   
                 GBAP 
                 acid (includes 
                   
                   
                   
               
               
                   
                   
                   
                 glucosylceramidase) 
                   
                   
                   
               
               
                   
                   
                   
                 /// glucosidase, 
                   
                   
                   
               
               
                   
                   
                   
                 beta; acid, 
                   
                   
                   
               
               
                   
                   
                   
                 pseudogene 
                   
                   
                   
               
               
                 201251_at 
                 NM_002654 
                 PKM2 
                 pyruvate kinase, 
                 0.0060 
                 0.0966 
                 −1.3 
               
               
                   
                   
                   
                 muscle 
                   
                   
                   
               
               
                 209372_x_at 
                 BF971587 
                 TUBB2A 
                 tubulin, beta 2A /// 
                 0.0382 
                 0.3610 
                 −1.3 
               
               
                   
                   
                 /// 
                 tubulin, beta 2B 
                   
                   
                   
               
               
                   
                   
                 TUBB2B 
                   
                   
                   
                   
               
               
                 218305_at 
                 NM_024658 
                 IPO4 
                 importin 4 
                 0.0192 
                 0.5264 
                 −1.3 
               
               
                 202418_at 
                 NM_020470 
                 YIF1A 
                 Yip1 interacting 
                 0.0156 
                 0.7400 
                 −1.3 
               
               
                   
                   
                   
                 factor homolog A 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 220966_x_at 
                 NM_030978 
                 ARPC5L 
                 actin related 
                 0.0059 
                 0.2710 
                 −1.3 
               
               
                   
                   
                   
                 protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 5-like /// actin 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 5-like 
                   
                   
                   
               
               
                 209186_at 
                 M23114 
                 ATP2A2 
                 ATPase, Ca++ 
                 0.0041 
                 0.0664 
                 −1.3 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 cardiac muscle, 
                   
                   
                   
               
               
                   
                   
                   
                 slow twitch 2 
                   
                   
                   
               
               
                 219646_at 
                 NM_017702 
                 FLJ20186 
                 hypothetical 
                 0.0012 
                 0.0732 
                 −1.3 
               
               
                   
                   
                   
                 protein FLJ20186 
                   
                   
                   
               
               
                 213887_s_at 
                 AI554759 
                 POLR2E 
                 polymerase (RNA) 
                 0.0006 
                 0.0629 
                 −1.3 
               
               
                   
                   
                   
                 II (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide E, 
                   
                   
                   
               
               
                   
                   
                   
                 25 kDa 
                   
                   
                   
               
               
                 219556_at 
                 NM_025108 
                 C16orf59 
                 chromosome 16 
                 0.0047 
                 0.7714 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 59 
                   
                   
                   
               
               
                 204975_at 
                 NM_001424 
                 EMP2 
                 epithelial 
                 0.0129 
                 0.1233 
                 −1.3 
               
               
                   
                   
                   
                 membrane protein 2 
                   
                   
                   
               
               
                 200628_s_at 
                 M61715 
                 WARS 
                 tryptophanyl-tRNA 
                 0.0060 
                 0.5095 
                 −1.3 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 221790_s_at 
                 AL545035 
                 LDLRAP1 
                 low density 
                 0.0220 
                 0.1822 
                 −1.3 
               
               
                   
                   
                   
                 lipoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 receptor adaptor 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 37996_s_at 
                 L08835 
                 DMPK 
                 dystrophia 
                 0.0037 
                 0.0582 
                 −1.3 
               
               
                   
                   
                   
                 myotonica-protein 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 
                   
                   
                   
               
               
                 208793_x_at 
                 AI744900 
                 SMARCA4 
                 SWI/SNF related, 
                 0.0195 
                 0.3604 
                 −1.3 
               
               
                   
                   
                 /// 
                 matrix associated, 
                   
                   
                   
               
               
                   
                   
                 MRPL43 
                 actin dependent 
                   
                   
                   
               
               
                   
                   
                   
                 regulator of 
                   
                   
                   
               
               
                   
                   
                   
                 chromatin, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily a, 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 /// 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L43 
                   
                   
                   
               
               
                 202262_x_at 
                 NM_013974 
                 DDAH2 
                 dimethylarginine 
                 0.0016 
                 0.2933 
                 −1.3 
               
               
                   
                   
                   
                 dimethylaminohydrolase 2 
                   
                   
                   
               
               
                 215489_x_at 
                 AI871287 
                 HOMER3 
                 homer homolog 3 
                 0.0462 
                 0.6112 
                 −1.3 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 210334_x_at 
                 AB028869 
                 BIRC5 
                 baculoviral IAP 
                 0.0111 
                 0.0735 
                 −1.3 
               
               
                   
                   
                   
                 repeat-containing 5 
                   
                   
                   
               
               
                   
                   
                   
                 (survivin) 
                   
                   
                   
               
               
                 213897_s_at 
                 AI832239 
                 MRPL23 
                 mitochondrial 
                 0.0054 
                 0.6849 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L23 
                   
                   
                   
               
               
                 212702_s_at 
                 N45111 
                 BICD2 
                 bicaudal D 
                 0.0304 
                 0.4187 
                 −1.3 
               
               
                   
                   
                   
                 homolog 2 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 217772_s_at 
                 NM_014342 
                 MTCH2 
                 mitochondrial 
                 0.0040 
                 0.6337 
                 −1.3 
               
               
                   
                   
                   
                 carrier homolog 2 
                   
                   
                   
               
               
                   
                   
                   
                 ( C. elegans ) 
                   
                   
                   
               
               
                 204441_s_at 
                 NM_002689 
                 POLA2 
                 polymerase (DNA 
                 0.0049 
                 0.1015 
                 −1.3 
               
               
                   
                   
                   
                 directed), alpha 2 
                   
                   
                   
               
               
                   
                   
                   
                 (70 kD subunit) 
                   
                   
                   
               
               
                 202275_at 
                 NM_000402 
                 G6PD 
                 glucose-6- 
                 0.0248 
                 0.1383 
                 −1.3 
               
               
                   
                   
                   
                 phosphate 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                 200045_at 
                 NM_001090 
                 ABCF1 
                 ATP-binding 
                 0.0051 
                 0.9326 
                 −1.3 
               
               
                   
                   
                   
                 cassette, sub- 
                   
                   
                   
               
               
                   
                   
                   
                 family F (GCN20), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 /// ATP- 
                   
                   
                   
               
               
                   
                   
                   
                 binding cassette, 
                   
                   
                   
               
               
                   
                   
                   
                 sub-family F 
                   
                   
                   
               
               
                   
                   
                   
                 (GCN20), member 1 
                   
                   
                   
               
               
                 209899_s_at 
                 AF217197 
                 SIAHBP1 
                 fuse-binding 
                 0.0015 
                 0.4831 
                 −1.3 
               
               
                   
                   
                   
                 protein-interacting 
                   
                   
                   
               
               
                   
                   
                   
                 repressor 
                   
                   
                   
               
               
                 202041_s_at 
                 NM_004214 
                 FIBP 
                 fibroblast growth 
                 0.0044 
                 0.2432 
                 −1.3 
               
               
                   
                   
                   
                 factor (acidic) 
                   
                   
                   
               
               
                   
                   
                   
                 intracellular 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 221853_s_at 
                 N39536 
                 NOMO1 
                 NODAL modulator 
                 0.0018 
                 0.2079 
                 −1.3 
               
               
                   
                   
                 /// 
                 1 /// NODAL 
                   
                   
                   
               
               
                   
                   
                 NOMO2 
                 modulator 2 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 NODAL modulator 3 
                   
                   
                   
               
               
                   
                   
                 NOMO3 
                   
                   
                   
                   
               
               
                 208836_at 
                 U51478 
                 ATP1B3 
                 ATPase, Na+/K+ 
                 0.0048 
                 0.9938 
                 −1.3 
               
               
                   
                   
                   
                 transporting, beta 3 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 
                   
                   
                   
               
               
                 214500_at 
                 AF044286 
                 H2AFY 
                 H2A histone 
                 0.0050 
                 0.5729 
                 −1.3 
               
               
                   
                   
                   
                 family, member Y 
                   
                   
                   
               
               
                 203025_at 
                 NM_003491 
                 ARD1A 
                 ARD1 homolog A, 
                 0.0376 
                 0.7352 
                 −1.3 
               
               
                   
                   
                   
                 N-acetyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 206452_x_at 
                 NM_021131 
                 PPP2R4 
                 protein 
                 0.0127 
                 0.2664 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase 2A, 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory subunit 
                   
                   
                   
               
               
                   
                   
                   
                 B′ (PR 53) 
                   
                   
                   
               
               
                 202326_at 
                 NM_006709 
                 EHMT2 
                 euchromatic 
                 0.0261 
                 0.4234 
                 −1.3 
               
               
                   
                   
                   
                 histone-lysine N- 
                   
                   
                   
               
               
                   
                   
                   
                 methyltransferase 2 
                   
                   
                   
               
               
                 218708_at 
                 NM_013248 
                 NXT1 
                 NTF2-dike export 
                 0.0016 
                 0.0699 
                 −1.3 
               
               
                   
                   
                   
                 factor 1 
                   
                   
                   
               
               
                 208353_x_at 
                 NM_020480 
                 ANK1 
                 ankyrin 1, 
                 0.0036 
                 0.5544 
                 −1.3 
               
               
                   
                   
                   
                 erythrocytic 
                   
                   
                   
               
               
                 218497_s_at 
                 NM_002936 
                 RNASEH1 
                 ribonuclease H1 
                 0.0043 
                 0.2176 
                 −1.3 
               
               
                 220864_s_at 
                 NM_015965 
                 NDUFA13 
                 NADH 
                 0.0101 
                 0.8591 
                 −1.3 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) 1 
                   
                   
                   
               
               
                   
                   
                   
                 alpha subcomplex, 
                   
                   
                   
               
               
                   
                   
                   
                 13 
                   
                   
                   
               
               
                 212708_at 
                 AV721987 
                 MSL-1 
                 male-specific 
                 0.0026 
                 0.2235 
                 −1.3 
               
               
                   
                   
                   
                 lethal-1 homolog 
                   
                   
                   
               
               
                 218223_s_at 
                 NM_016274 
                 PLEKHO1 
                 pleckstrin 
                 0.0247 
                 0.8246 
                 −1.3 
               
               
                   
                   
                   
                 homology domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing, family 
                   
                   
                   
               
               
                   
                   
                   
                 O member 1 
                   
                   
                   
               
               
                 203119_at 
                 NM_024098 
                 CCDC86 
                 coiled-coil domain 
                 0.0040 
                 0.1268 
                 −1.3 
               
               
                   
                   
                   
                 containing 86 
                   
                   
                   
               
               
                 200660_at 
                 NM_005620 
                 S100A11 
                 S100 calcium 
                 0.0007 
                 0.1105 
                 −1.3 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 A11 
                   
                   
                   
               
               
                 218918_at 
                 NM_020379 
                 MAN1C1 
                 mannosidase, 
                 0.0076 
                 0.6532 
                 −1.3 
               
               
                   
                   
                   
                 alpha, class 1C, 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 222065_s_at 
                 AI830227 
                 FLII 
                 flightless I 
                 0.0066 
                 0.2358 
                 −1.3 
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 217946_s_at 
                 NM_016402 
                 SAE1 
                 SUMO1 activating 
                 0.0007 
                 0.1017 
                 −1.3 
               
               
                   
                   
                   
                 enzyme subunit 1 
                   
                   
                   
               
               
                 211799_x_at 
                 U62824 
                 HLA-C 
                 major 
                 0.0098 
                 0.7199 
                 −1.3 
               
               
                   
                   
                   
                 histocompatibility 
                   
                   
                   
               
               
                   
                   
                   
                 complex, class I, C 
                   
                   
                   
               
               
                 200055_at 
                 NM_006284 
                 TAF10 
                 TAF10 RNA 
                 0.0029 
                 0.2192 
                 −1.3 
               
               
                   
                   
                   
                 polymerase II, 
                   
                   
                   
               
               
                   
                   
                   
                 TATA box binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein (TBP)- 
                   
                   
                   
               
               
                   
                   
                   
                 associated factor, 
                   
                   
                   
               
               
                   
                   
                   
                 30 kDa /// TAF10 
                   
                   
                   
               
               
                   
                   
                   
                 RNA polymerase 
                   
                   
                   
               
               
                   
                   
                   
                 II, TATA box 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                   
                   
                   
                 (TBP)-associated 
                   
                   
                   
               
               
                   
                   
                   
                 factor, 30 kDa 
                   
                   
                   
               
               
                 209478_at 
                 U95006 
                 PCDHGC3 
                 Protocadherin 
                 0.0036 
                 0.4002 
                 −1.3 
               
               
                   
                   
                   
                 gamma subfamily 
                   
                   
                   
               
               
                   
                   
                   
                 C, 3 
                   
                   
                   
               
               
                 218897_at 
                 NM_030577 
                 TMEM177 
                 transmembrane 
                 0.0063 
                 0.9572 
                 −1.3 
               
               
                   
                   
                   
                 protein 177 
                   
                   
                   
               
               
                 39835_at 
                 U93181 
                 SBF1 
                 SET binding factor 1 
                 0.0015 
                 0.0290 
                 −1.3 
               
               
                 212437_at 
                 AL109804 
                 CENPB 
                 centromere protein 
                 0.0286 
                 0.3415 
                 −1.3 
               
               
                   
                   
                   
                 B, 80 kDa 
                   
                   
                   
               
               
                 203871_at 
                 NM_015670 
                 SENP3 
                 SUMO1/sentrin/SMT3 
                 0.0190 
                 0.2427 
                 −1.3 
               
               
                   
                   
                   
                 specific 
                   
                   
                   
               
               
                   
                   
                   
                 peptidase 3 
                   
                   
                   
               
               
                 218358_at 
                 NM_024324 
                 CCNK 
                 Cyclin K 
                 0.0044 
                 0.3329 
                 −1.3 
               
               
                 213892_s_at 
                 AA927724 
                 APRT 
                 adenine 
                 0.0040 
                 0.8086 
                 −1.3 
               
               
                   
                   
                   
                 phosphoribosyltransferase 
                   
                   
                   
               
               
                 220789_s_at 
                 NM_004749 
                 TBRG4 
                 transforming 
                 0.0323 
                 0.4333 
                 −1.3 
               
               
                   
                   
                   
                 growth factor beta 
                   
                   
                   
               
               
                   
                   
                   
                 regulator 4 
                   
                   
                   
               
               
                 202758_s_at 
                 NM_003721 
                 RFXANK 
                 regulatory factor 
                 0.0032 
                 0.3094 
                 −1.3 
               
               
                   
                   
                   
                 X-associated 
                   
                   
                   
               
               
                   
                   
                   
                 ankyrin-containing 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 208620_at 
                 U24223 
                 PCBP1 
                 poly(rC) binding 
                 0.0021 
                 0.1368 
                 −1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 200768_s_at 
                 BC001686 
                 MAT2A 
                 methionine 
                 0.0073 
                 0.0436 
                 −1.3 
               
               
                   
                   
                   
                 adenosyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 II, alpha 
                   
                   
                   
               
               
                 201937_s_at 
                 NM_012100 
                 DNPEP 
                 aspartyl 
                 0.0117 
                 0.4038 
                 −1.3 
               
               
                   
                   
                   
                 aminopeptidase 
                   
                   
                   
               
               
                 209536_s_at 
                 AF320070 
                 EHD4 
                 EH-domain 
                 0.0246 
                 0.4627 
                 −1.3 
               
               
                   
                   
                   
                 containing 4 
                   
                   
                   
               
               
                 201727_s_at 
                 NM_001419 
                 ELAVL1 
                 ELAV (embryonic 
                 0.0184 
                 0.5267 
                 −1.3 
               
               
                   
                   
                   
                 lethal, abnormal 
                   
                   
                   
               
               
                   
                   
                   
                 vision, 
                   
                   
                   
               
               
                   
                   
                   
                   Drosophila )-like 1 
                   
                   
                   
               
               
                   
                   
                   
                 (Hu antigen R) 
                   
                   
                   
               
               
                 202715_at 
                 NM_004341 
                 CAD /// 
                 carbamoyl- 
                 0.0029 
                 0.1198 
                 −1.3 
               
               
                   
                   
                 ARHGEF5 
                 phosphate 
                   
                   
                   
               
               
                   
                   
                 /// 
                 synthetase 2, 
                   
                   
                   
               
               
                   
                   
                 LOC653691 
                 aspartate 
                   
                   
                   
               
               
                   
                   
                   
                 transcarbamylase, 
                   
                   
                   
               
               
                   
                   
                   
                 and dihydroorotase 
                   
                   
                   
               
               
                   
                   
                   
                 /// Rho guanine 
                   
                   
                   
               
               
                   
                   
                   
                 nucleotide 
                   
                   
                   
               
               
                   
                   
                   
                 exchange factor 
                   
                   
                   
               
               
                   
                   
                   
                 (GEF) 5 /// 
                   
                   
                   
               
               
                   
                   
                   
                 FLJ40722-like 
                   
                   
                   
               
               
                 202330_s_at 
                 NM_003362 
                 UNG 
                 uracil-DNA 
                 0.0046 
                 0.1330 
                 −1.3 
               
               
                   
                   
                   
                 glycosylase 
                   
                   
                   
               
               
                 215464_s_at 
                 AK001327 
                 TAX1BP3 
                 Tax1 (human T- 
                 0.0038 
                 0.2644 
                 −1.3 
               
               
                   
                   
                   
                 cell leukemia virus 
                   
                   
                   
               
               
                   
                   
                   
                 type I) binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 3 
                   
                   
                   
               
               
                 204099_at 
                 NM_003078 
                 SMARCD3 
                 SWI/SNF related, 
                 0.0047 
                 0.4707 
                 −1.3 
               
               
                   
                   
                   
                 matrix associated, 
                   
                   
                   
               
               
                   
                   
                   
                 actin dependent 
                   
                   
                   
               
               
                   
                   
                   
                 regulator of 
                   
                   
                   
               
               
                   
                   
                   
                 chromatin, 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily d, 
                   
                   
                   
               
               
                   
                   
                   
                 member 3 
                   
                   
                   
               
               
                 203622_s_at 
                 NM_020143 
                 PNO1 
                 partner of NOB1 
                 0.0066 
                 0.0727 
                 −1.3 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 203940_s_at 
                 NM_014909 
                 VASH1 
                 vasohibin 1 
                 0.0107 
                 0.7646 
                 −1.3 
               
               
                 203349_s_at 
                 NM_004454 
                 ETV5 
                 ets variant gene 5 
                 0.0074 
                 0.5793 
                 −1.3 
               
               
                   
                   
                   
                 (ets-related 
                   
                   
                   
               
               
                   
                   
                   
                 molecule) 
                   
                   
                   
               
               
                 200739_s_at 
                 BG338532 
                 SUMO3 
                 SMT3 suppressor 
                 0.0146 
                 0.1657 
                 −1.3 
               
               
                   
                   
                   
                 of mif two 3 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 3 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209765_at 
                 Y13786 
                 ADAM19 
                 ADAM 
                 0.0079 
                 0.4707 
                 −1.3 
               
               
                   
                   
                   
                 metallopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 domain 19 (meltrin 
                   
                   
                   
               
               
                   
                   
                   
                 beta) 
                   
                   
                   
               
               
                 200601_at 
                 U48734 
                 ACTN4 
                 actinin, alpha 4 
                 0.0062 
                 0.0990 
                 −1.3 
               
               
                 208433_s_at 
                 NM_017522 
                 LRP8 
                 low density 
                 0.0212 
                 0.7888 
                 −1.3 
               
               
                   
                   
                   
                 lipoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 receptor-related 
                   
                   
                   
               
               
                   
                   
                   
                 protein 8, 
                   
                   
                   
               
               
                   
                   
                   
                 apolipoprotein e 
                   
                   
                   
               
               
                   
                   
                   
                 receptor 
                   
                   
                   
               
               
                 200913_at 
                 NM_002707 
                 PPM1G 
                 protein 
                 0.0107 
                 0.3412 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase 1G 
                   
                   
                   
               
               
                   
                   
                   
                 (formerly 2C), 
                   
                   
                   
               
               
                   
                   
                   
                 magnesium- 
                   
                   
                   
               
               
                   
                   
                   
                 dependent, gamma 
                   
                   
                   
               
               
                   
                   
                   
                 isoform 
                   
                   
                   
               
               
                 212185_x_at 
                 NM_005953 
                 MT2A 
                 metallothionein 2A 
                 0.0015 
                 0.0280 
                 −1.3 
               
               
                 212624_s_at 
                 BF339445 
                 CHN1 
                 chimerin 
                 0.0259 
                 0.8804 
                 −1.3 
               
               
                   
                   
                   
                 (chimaerin) 1 
                   
                   
                   
               
               
                 202756_s_at 
                 NM_002081 
                 GPC1 
                 glypican 1 
                 0.0074 
                 0.7875 
                 −1.3 
               
               
                 201246_s_at 
                 NM_017670 
                 OTUB1 
                 OTU domain, 
                 0.0481 
                 0.7828 
                 −1.3 
               
               
                   
                   
                   
                 ubiquitin aldehyde 
                   
                   
                   
               
               
                   
                   
                   
                 binding 1 
                   
                   
                   
               
               
                 202761_s_at 
                 NM_015180 
                 SYNE2 
                 spectrin repeat 
                 0.0415 
                 0.0995 
                 −1.3 
               
               
                   
                   
                   
                 containing, nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 envelope 2 
                   
                   
                   
               
               
                 204317_at 
                 BF305380 
                 GTSE1 
                 G-2 and S-phase 
                 0.0250 
                 0.1113 
                 −1.3 
               
               
                   
                   
                   
                 expressed 1 
                   
                   
                   
               
               
                 217913_at 
                 NM_013245 
                 VPS4A 
                 vacuolar protein 
                 0.0007 
                 0.1899 
                 −1.3 
               
               
                   
                   
                   
                 sorting 4 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 A ( S. cerevisiae ) 
                   
                   
                   
               
               
                 212005_at 
                 AL582808 
                 — 
                 — 
                 0.0086 
                 0.1735 
                 −1.3 
               
               
                 200075_s_at 
                 BC006249 
                 GUK1 
                 guanylate kinase 1 
                 0.0214 
                 0.6352 
                 −1.3 
               
               
                   
                   
                   
                 /// guanylate kinase 1 
                   
                   
                   
               
               
                 221848_at 
                 AL121845 
                 ZGPAT 
                 zinc finger, CCCH- 
                 0.0015 
                 0.0424 
                 −1.3 
               
               
                   
                   
                   
                 type with G patch 
                   
                   
                   
               
               
                   
                   
                   
                 domain 
                   
                   
                   
               
               
                 218083_at 
                 NM_025072 
                 PTGES2 
                 prostaglandin E 
                 0.0123 
                 0.5372 
                 −1.3 
               
               
                   
                   
                   
                 synthase 2 
                   
                   
                   
               
               
                 206050_s_at 
                 NM_002939 
                 RNH1 
                 ribonuclease/angiogenin 
                 0.0018 
                 0.8628 
                 −1.3 
               
               
                   
                   
                   
                 inhibitor 1 
                   
                   
                   
               
               
                 209468_at 
                 AB017498 
                 LRP5 
                 low density 
                 0.0212 
                 0.8184 
                 −1.3 
               
               
                   
                   
                   
                 lipoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 receptor-related 
                   
                   
                   
               
               
                   
                   
                   
                 protein 5 
                   
                   
                   
               
               
                 209103_s_at 
                 BC001049 
                 UFD1L 
                 ubiquitin fusion 
                 0.0034 
                 0.2084 
                 −1.3 
               
               
                   
                   
                   
                 degradation 1 like 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 218070_s_at 
                 NM_013335 
                 GMPPA 
                 GDP-mannose 
                 0.0192 
                 0.1434 
                 −1.3 
               
               
                   
                   
                   
                 pyrophosphorylase A 
                   
                   
                   
               
               
                 201389_at 
                 NM_002205 
                 ITGA5 
                 integrin, alpha 5 
                 0.0122 
                 0.1383 
                 −1.3 
               
               
                   
                   
                   
                 (fibronectin 
                   
                   
                   
               
               
                   
                   
                   
                 receptor, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide) 
                   
                   
                   
               
               
                 215084_s_at 
                 AL031427 
                 LRRC42 
                 leucine rich repeat 
                 0.0036 
                 0.4075 
                 −1.3 
               
               
                   
                   
                   
                 containing 42 
                   
                   
                   
               
               
                 218388_at 
                 NM_012088 
                 PGLS 
                 6- 
                 0.0008 
                 0.0332 
                 −1.3 
               
               
                   
                   
                   
                 phosphogluconolactonase 
                   
                   
                   
               
               
                 201126_s_at 
                 NM_002406 
                 MGAT1 
                 mannosyl (alpha- 
                 0.0185 
                 0.7484 
                 −1.3 
               
               
                   
                   
                   
                 1,3-)-glycoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 beta-1,2-N- 
                   
                   
                   
               
               
                   
                   
                   
                 acetylglucosaminyl 
                   
                   
                   
               
               
                   
                   
                   
                 transferase 
                   
                   
                   
               
               
                 210519_s_at 
                 BC000906 
                 NQO1 
                 NAD(P)H 
                 0.0128 
                 0.4020 
                 −1.3 
               
               
                   
                   
                   
                 dehydrogenase, 
                   
                   
                   
               
               
                   
                   
                   
                 quinone 1 
                   
                   
                   
               
               
                 218238_at 
                 NM_012341 
                 GTPBP4 
                 GTP binding 
                 0.0378 
                 0.1778 
                 −1.3 
               
               
                   
                   
                   
                 protein 4 
                   
                   
                   
               
               
                 208905_at 
                 BC005299 
                 CYCS 
                 cytochrome c, 
                 0.0052 
                 0.0872 
                 −1.3 
               
               
                   
                   
                   
                 somatic 
                   
                   
                   
               
               
                 207332_s_at 
                 NM_003234 
                 TFRC 
                 transferrin receptor 
                 0.0035 
                 0.4831 
                 −1.3 
               
               
                   
                   
                   
                 (p90, CD71) 
                   
                   
                   
               
               
                 218069_at 
                 NM_024096 
                 XTP3TPA 
                 XTP3- 
                 0.0040 
                 0.1290 
                 −1.3 
               
               
                   
                   
                   
                 transactivated 
                   
                   
                   
               
               
                   
                   
                   
                 protein A 
                   
                   
                   
               
               
                 211982_x_at 
                 AL546600 
                 XPO6 
                 exportin 6 
                 0.0049 
                 0.9166 
                 −1.3 
               
               
                 202024_at 
                 NM_004317 
                 ASNA1 
                 arsA arsenite 
                 0.0058 
                 0.1066 
                 −1.3 
               
               
                   
                   
                   
                 transporter, ATP- 
                   
                   
                   
               
               
                   
                   
                   
                 binding, homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 (bacterial) 
                   
                   
                   
               
               
                 221657_s_at 
                 BC001719 
                 ASB6 
                 ankyrin repeat and 
                 0.0233 
                 0.7801 
                 −1.3 
               
               
                   
                   
                   
                 SOCS box- 
                   
                   
                   
               
               
                   
                   
                   
                 containing 6 
                   
                   
                   
               
               
                 220964_s_at 
                 NM_030981 
                 RAB1B 
                 RAB1B, member 
                 0.0162 
                 0.2294 
                 −1.3 
               
               
                   
                   
                   
                 RAS oncogene 
                   
                   
                   
               
               
                   
                   
                   
                 family /// RAB1B, 
                   
                   
                   
               
               
                   
                   
                   
                 member RAS 
                   
                   
                   
               
               
                   
                   
                   
                 oncogene family 
                   
                   
                   
               
               
                 203931_s_at 
                 NM_002949 
                 MRPL12 
                 mitochondrial 
                 0.0045 
                 0.5499 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L12 
                   
                   
                   
               
               
                 208842_s_at 
                 W93787 
                 GORASP2 
                 golgi reassembly 
                 0.0042 
                 0.8638 
                 −1.3 
               
               
                   
                   
                   
                 stacking protein 2, 
                   
                   
                   
               
               
                   
                   
                   
                 55 kDa 
                   
                   
                   
               
               
                 215905_s_at 
                 AL157420 
                 WDR57 
                 WD repeat domain 
                 0.0023 
                 0.4162 
                 −1.3 
               
               
                   
                   
                   
                 57 (US snRNP 
                   
                   
                   
               
               
                   
                   
                   
                 specific) 
                   
                   
                   
               
               
                 212422_at 
                 AL547263 
                 PDCD11 
                 programmed cell 
                 0.0197 
                 0.3396 
                 −1.3 
               
               
                   
                   
                   
                 death 11 
                   
                   
                   
               
               
                 211730_s_at 
                 BC005903 
                 POLR2L 
                 polymerase (RNA) 
                 0.0030 
                 0.5416 
                 −1.3 
               
               
                   
                   
                   
                 II (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide L, 
                   
                   
                   
               
               
                   
                   
                   
                 7.6 kDa /// 
                   
                   
                   
               
               
                   
                   
                   
                 polymerase (RNA) 
                   
                   
                   
               
               
                   
                   
                   
                 II (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide L, 
                   
                   
                   
               
               
                   
                   
                   
                 7.6 kDa 
                   
                   
                   
               
               
                 202264_s_at 
                 NM_006114 
                 TOMM40 
                 translocase of outer 
                 0.0150 
                 0.7824 
                 −1.3 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 membrane 40 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 209731_at 
                 U79718 
                 NTHL1 
                 nth endonuclease 
                 0.0137 
                 0.6042 
                 −1.3 
               
               
                   
                   
                   
                 III-like 1 ( E. coli ) 
                   
                   
                   
               
               
                 217897_at 
                 NM_022003 
                 FXYD6 
                 FXYD domain 
                 0.0017 
                 0.0447 
                 −1.3 
               
               
                   
                   
                   
                 containing ion 
                   
                   
                   
               
               
                   
                   
                   
                 transport regulator 6 
                   
                   
                   
               
               
                 211564_s_at 
                 BC003096 
                 PDLIM4 
                 PDZ and LIM 
                 0.0124 
                 0.6209 
                 −1.3 
               
               
                   
                   
                   
                 domain 4 
                   
                   
                   
               
               
                 203545_at 
                 NM_024079 
                 ALG8 
                 asparagine-linked 
                 0.0125 
                 0.2016 
                 −1.3 
               
               
                   
                   
                   
                 glycosylation 8 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae , 
                   
                   
                   
               
               
                   
                   
                   
                 alpha- 
                   
                   
                   
               
               
                   
                   
                   
                 1,3- 
                   
                   
                   
               
               
                   
                   
                   
                 glucosyltransferase) 
                   
                   
                   
               
               
                 217099_s_at 
                 AF258545 
                 GEMIN4 
                 gem (nuclear 
                 0.0117 
                 0.5238 
                 −1.3 
               
               
                   
                   
                   
                 organelle) 
                   
                   
                   
               
               
                   
                   
                   
                 associated protein 4 
                   
                   
                   
               
               
                 218641_at 
                 NM_023941 
                 MGC3032 
                 hypothetical 
                 0.0135 
                 0.6803 
                 −1.3 
               
               
                   
                   
                   
                 protein MGC3032 
                   
                   
                   
               
               
                 212411_at 
                 BE747342 
                 IMP4 
                 IMP4, U3 small 
                 0.0178 
                 0.5931 
                 −1.3 
               
               
                   
                   
                   
                 nucleolar 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein, 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 214794_at 
                 BF669264 
                 DLST 
                 dihydrolipoamide 
                 0.0235 
                 0.9380 
                 −1.3 
               
               
                   
                   
                   
                 S- 
                   
                   
                   
               
               
                   
                   
                   
                 succinyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (E2 component of 
                   
                   
                   
               
               
                   
                   
                   
                 2-oxo-glutarate 
                   
                   
                   
               
               
                   
                   
                   
                 complex) 
                   
                   
                   
               
               
                 203311_s_at 
                 M57763 
                 ARF6 
                 ADP-ribosylation 
                 0.0425 
                 0.3117 
                 −1.3 
               
               
                   
                   
                   
                 factor 6 
                   
                   
                   
               
               
                 221676_s_at 
                 BC002342 
                 CORO1C 
                 coronin, actin 
                 0.0093 
                 0.5425 
                 −1.3 
               
               
                   
                   
                   
                 binding protein, 1C 
                   
                   
                   
               
               
                 218670_at 
                 NM_025215 
                 PUS1 
                 pseudouridylate 
                 0.0305 
                 0.2781 
                 −1.3 
               
               
                   
                   
                   
                 synthase 1 
                   
                   
                   
               
               
                 212003_at 
                 BG171020 
                 C1orf144 
                 chromosome 1 
                 0.0349 
                 0.4840 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 144 
                   
                   
                   
               
               
                 211576_s_at 
                 BC003068 
                 SLC19A1 
                 solute carrier 
                 0.0047 
                 0.1028 
                 −1.3 
               
               
                   
                   
                   
                 family 19 (folate 
                   
                   
                   
               
               
                   
                   
                   
                 transporter), 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 201817_at 
                 NM_014671 
                 UBE3C 
                 ubiquitin protein 
                 0.0429 
                 0.6649 
                 −1.3 
               
               
                   
                   
                   
                 ligase E3C 
                   
                   
                   
               
               
                 220956_s_at 
                 NM_017555 
                 EGLN2 
                 egl nine homolog 2 
                 0.0078 
                 0.7604 
                 −1.3 
               
               
                   
                   
                   
                 ( C. elegans ) 
                   
                   
                   
               
               
                 208910_s_at 
                 L04636 
                 C1QBP 
                 complement 
                 0.0329 
                 0.3231 
                 −1.3 
               
               
                   
                   
                   
                 component 1, q 
                   
                   
                   
               
               
                   
                   
                   
                 subcomponent 
                   
                   
                   
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 203462_x_at 
                 NM_003751 
                 EIF3S9 
                 eukaryotic 
                 0.0017 
                 0.1620 
                 −1.3 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 3, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 9 eta, 
                   
                   
                   
               
               
                   
                   
                   
                 116 kDa 
                   
                   
                   
               
               
                 218834_s_at 
                 NM_017870 
                 TMEM132A 
                 transmembrane 
                 0.0106 
                 0.1838 
                 −1.3 
               
               
                   
                   
                   
                 protein 132A 
                   
                   
                   
               
               
                 208932_at 
                 BC001416 
                 PPP4C 
                 protein 
                 0.0040 
                 0.1494 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase 4 
                   
                   
                   
               
               
                   
                   
                   
                 (formerly X), 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic subunit 
                   
                   
                   
               
               
                 203228_at 
                 NM_002573 
                 PAFAH1B3 
                 platelet-activating 
                 0.0041 
                 0.2248 
                 −1.3 
               
               
                   
                   
                   
                 factor 
                   
                   
                   
               
               
                   
                   
                   
                 acetylhydrolase, 
                   
                   
                   
               
               
                   
                   
                   
                 isoform Ib, gamma 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 29 kDa 
                   
                   
                   
               
               
                 203031_s_at 
                 NM_000375 
                 UROS 
                 uroporphyrinogen 
                 0.0130 
                 0.8462 
                 −1.3 
               
               
                   
                   
                   
                 III synthase 
                   
                   
                   
               
               
                   
                   
                   
                 (congenital 
                   
                   
                   
               
               
                   
                   
                   
                 erythropoietic 
                   
                   
                   
               
               
                   
                   
                   
                 porphyria) 
                   
                   
                   
               
               
                 203647_s_at 
                 M18003 
                 FDX1 
                 ferredoxin 1 
                 0.0430 
                 0.8149 
                 −1.3 
               
               
                 217225_x_at 
                 AL512687 
                 NOMO2 
                 NODAL modulator 2 
                 0.0042 
                 0.2518 
                 −1.3 
               
               
                 201095_at 
                 NM_004394 
                 DAP 
                 death-associated 
                 0.0166 
                 0.2794 
                 −1.3 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 202128_at 
                 NM_014821 
                 KIAA0317 
                 KIAA0317 
                 0.0446 
                 0.9567 
                 −1.3 
               
               
                 212129_at 
                 AI589507 
                 NIPA2 
                 non imprinted in 
                 0.0163 
                 0.7517 
                 −1.3 
               
               
                   
                   
                   
                 Prader- 
                   
                   
                   
               
               
                   
                   
                   
                 Willi/Angelman 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome 2 
                   
                   
                   
               
               
                 204610_s_at 
                 NM_006848 
                 CCDC85B 
                 coiled-coil domain 
                 0.0377 
                 0.4333 
                 −1.3 
               
               
                   
                   
                   
                 containing 85B 
                   
                   
                   
               
               
                 215093_at 
                 U82671 
                 NSDHL 
                 NAD(P) dependent 
                 0.0159 
                 0.7567 
                 −1.3 
               
               
                   
                   
                   
                 steroid 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase-like 
                   
                   
                   
               
               
                 200950_at 
                 NM_006409 
                 ARPC1A 
                 actin related 
                 0.0115 
                 0.7012 
                 −1.3 
               
               
                   
                   
                   
                 protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 1A, 41 kDa 
                   
                   
                   
               
               
                 217716_s_at 
                 NM_013336 
                 SEC61A1 
                 Sec61 alpha 1 
                 0.0045 
                 0.0475 
                 −1.3 
               
               
                   
                   
                   
                 subunit ( S. cerevisiae ) 
                   
                   
                   
               
               
                 208132_x_at 
                 NM_004638 
                 BAT2 
                 HLA-B associated 
                 0.0051 
                 0.1305 
                 −1.3 
               
               
                   
                   
                   
                 transcript 2 
                   
                   
                   
               
               
                 203960_s_at 
                 NM_016126 
                 C1orf41 
                 chromosome 1 
                 0.0053 
                 0.0645 
                 −1.3 
               
               
                   
                   
                 /// 
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                 IL17RB 
                 41 /// interleukin 
                   
                   
                   
               
               
                   
                   
                   
                 17 receptor B 
                   
                   
                   
               
               
                 201950_x_at 
                 NM_004930 
                 CAPZB 
                 capping protein 
                 0.0107 
                 0.4512 
                 −1.3 
               
               
                   
                   
                   
                 (actin filament) 
                   
                   
                   
               
               
                   
                   
                   
                 muscle Z-line, beta 
                   
                   
                   
               
               
                 210966_x_at 
                 BC001460 
                 LARP1 
                 La 
                 0.0155 
                 0.1383 
                 −1.3 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 domain family, 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 210983_s_at 
                 AF279900 
                 MCM7 
                 MCM7 
                 0.0031 
                 0.0832 
                 −1.3 
               
               
                   
                   
                   
                 minichromosome 
                   
                   
                   
               
               
                   
                   
                   
                 maintenance 
                   
                   
                   
               
               
                   
                   
                   
                 deficient 7 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 200803_s_at 
                 AF033095 
                 TEGT 
                 testis enhanced 
                 0.0061 
                 0.0745 
                 −1.3 
               
               
                   
                   
                   
                 gene transcript 
                   
                   
                   
               
               
                   
                   
                   
                 (BAX inhibitor 1) 
                   
                   
                   
               
               
                 201554_x_at 
                 NM_004130 
                 GYG1 
                 glycogenin 1 
                 0.0267 
                 0.7594 
                 −1.3 
               
               
                 205462_s_at 
                 NM_002149 
                 HPCAL1 
                 hippocalcin-like 1 
                 0.0193 
                 0.2490 
                 −1.3 
               
               
                 211934_x_at 
                 W87689 
                 GANAB 
                 glucosidase, alpha; 
                 0.0072 
                 0.0476 
                 −1.3 
               
               
                   
                   
                   
                 neutral AB 
                   
                   
                   
               
               
                 209344_at 
                 BC002827 
                 TPM4 
                 tropomyosin 4 
                 0.0239 
                 0.8829 
                 −1.3 
               
               
                 217753_s_at 
                 NM_001029 
                 RPS26 /// 
                 ribosomal protein 
                 0.0010 
                 0.1482 
                 −1.3 
               
               
                   
                   
                 LOC644166 
                 S26 /// similar to 
                   
                   
                   
               
               
                   
                   
                 /// 
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                 LOC644191 
                 protein S26 /// 
                   
                   
                   
               
               
                   
                   
                 /// 
                 similar to 40S 
                   
                   
                   
               
               
                   
                   
                 LOC728937 
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S26 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 40S ribosomal 
                   
                   
                   
               
               
                   
                   
                   
                 protein S26 
                   
                   
                   
               
               
                 219575_s_at 
                 NM_022341 
                 PDF /// 
                 peptide 
                 0.0154 
                 0.7836 
                 −1.3 
               
               
                   
                   
                 COG8 
                 deformylase 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial) /// 
                   
                   
                   
               
               
                   
                   
                   
                 component of 
                   
                   
                   
               
               
                   
                   
                   
                 oligomeric golgi 
                   
                   
                   
               
               
                   
                   
                   
                 complex 8 
                   
                   
                   
               
               
                 203683_s_at 
                 NM_003377 
                 VEGFB 
                 vascular 
                 0.0305 
                 0.4504 
                 −1.3 
               
               
                   
                   
                   
                 endothelial growth 
                   
                   
                   
               
               
                   
                   
                   
                 factor B 
                   
                   
                   
               
               
                 204608_at 
                 NM_000048 
                 ASL 
                 argininosuccinate 
                 0.0071 
                 0.2170 
                 −1.3 
               
               
                   
                   
                   
                 lyase 
                   
                   
                   
               
               
                 202085_at 
                 NM_004817 
                 TJP2 
                 tight junction 
                 0.0110 
                 0.3198 
                 −1.3 
               
               
                   
                   
                   
                 protein 2 (zona 
                   
                   
                   
               
               
                   
                   
                   
                 occludens 2) 
                   
                   
                   
               
               
                 204275_at 
                 AI796687 
                 SOLH 
                 small optic lobes 
                 0.0350 
                 0.2001 
                 −1.3 
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 212120_at 
                 BE897886 
                 RHOQ 
                 ras homolog gene 
                 0.0062 
                 0.0571 
                 −1.3 
               
               
                   
                   
                   
                 family, member Q 
                   
                   
                   
               
               
                 200737_at 
                 NM_000291 
                 PGK1 
                 phosphoglycerate 
                 0.0017 
                 0.3518 
                 −1.3 
               
               
                   
                   
                   
                 kinase 1 
                   
                   
                   
               
               
                 219675_s_at 
                 NM_025076 
                 UXS1 
                 UDP-glucuronate 
                 0.0279 
                 0.7782 
                 −1.3 
               
               
                   
                   
                   
                 decarboxylase 1 
                   
                   
                   
               
               
                 209409_at 
                 D86962 
                 GRB10 
                 growth factor 
                 0.0104 
                 0.0935 
                 −1.3 
               
               
                   
                   
                   
                 receptor-bound 
                   
                   
                   
               
               
                   
                   
                   
                 protein 10 
                   
                   
                   
               
               
                 200806_s_at 
                 BE256479 
                 HSPD1 
                 heat shock 60 kDa 
                 0.0042 
                 0.1925 
                 −1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                   
                   
                   
                 (chaperonin) 
                   
                   
                   
               
               
                 201614_s_at 
                 NM_003707 
                 RUVBL1 
                 RuvB-like 1 ( E. coli ) 
                 0.0029 
                 0.0941 
                 −1.3 
               
               
                 222116_s_at 
                 AL157485 
                 TBC1D16 
                 TBC1 domain 
                 0.0107 
                 0.3474 
                 −1.3 
               
               
                   
                   
                   
                 family, member 16 
                   
                   
                   
               
               
                 203806_s_at 
                 NM_000135 
                 FANCA 
                 Fanconi anemia, 
                 0.0370 
                 0.5381 
                 −1.3 
               
               
                   
                   
                   
                 complementation 
                   
                   
                   
               
               
                   
                   
                   
                 group A /// Fanconianemia, 
                   
                   
                   
               
               
                   
                   
                   
                 complementation 
                   
                   
                   
               
               
                   
                   
                   
                 group A 
                   
                   
                   
               
               
                 213180_s_at 
                 BE895285 
                 GOSR2 
                 golgi SNAP 
                 0.0408 
                 0.2254 
                 −1.3 
               
               
                   
                   
                   
                 receptor complex 
                   
                   
                   
               
               
                   
                   
                   
                 member 2 
                   
                   
                   
               
               
                 203184_at 
                 NM_001999 
                 FBN2 
                 fibrillin 2 
                 0.0227 
                 0.1383 
                 −1.3 
               
               
                   
                   
                   
                 (congenital 
                   
                   
                   
               
               
                   
                   
                   
                 contractural 
                   
                   
                   
               
               
                   
                   
                   
                 arachnodactyly) 
                   
                   
                   
               
               
                 201911_s_at 
                 NM_005766 
                 FARP1 
                 FERM, RhoGEF 
                 0.0107 
                 0.6444 
                 −1.3 
               
               
                   
                   
                   
                 (ARHGEF) and 
                   
                   
                   
               
               
                   
                   
                   
                 pleckstrin domain 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                   
                   
                   
                 (chondrocyte- 
                   
                   
                   
               
               
                   
                   
                   
                 derived) 
                   
                   
                   
               
               
                 218057_x_at 
                 NM_006067 
                 COX4NB 
                 COX4 neighbor 
                 0.0136 
                 0.1344 
                 −1.3 
               
               
                 44783_s_at 
                 R61374 
                 HEY1 
                 hairy/enhancer-of- 
                 0.0156 
                 0.0964 
                 −1.3 
               
               
                   
                   
                   
                 split related with 
                   
                   
                   
               
               
                   
                   
                   
                 YRPW motif 1 
                   
                   
                   
               
               
                 200644_at 
                 NM_023009 
                 MARCKSL1 
                 MARCKS-like 1 
                 0.0011 
                 0.4243 
                 −1.3 
               
               
                 203276_at 
                 NM_005573 
                 LMNB1 
                 lamin B1 
                 0.0156 
                 0.5237 
                 −1.3 
               
               
                 212159_x_at 
                 AI125280 
                 AP2A2 
                 adaptor-related 
                 0.0342 
                 0.5742 
                 −1.3 
               
               
                   
                   
                   
                 protein complex 2, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 2 subunit 
                   
                   
                   
               
               
                 204839_at 
                 NM_015918 
                 POP5 
                 processing of 
                 0.0121 
                 0.4107 
                 −1.3 
               
               
                   
                   
                   
                 precursor 5, 
                   
                   
                   
               
               
                   
                   
                   
                 ribonuclease 
                   
                   
                   
               
               
                   
                   
                   
                 P/MRP subunit ( S. cerevisiae ) 
                   
                   
                   
               
               
                 201522_x_at 
                 NM_003097 
                 SNRPN /// 
                 small nuclear 
                 0.0035 
                 0.4870 
                 −1.3 
               
               
                   
                   
                 SNURF 
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide N /// 
                   
                   
                   
               
               
                   
                   
                   
                 SNRPN upstream 
                   
                   
                   
               
               
                   
                   
                   
                 reading frame 
                   
                   
                   
               
               
                 200727_s_at 
                 AA699583 
                 ACTR2 
                 ARP2 actin-related 
                 0.0170 
                 0.1805 
                 −1.3 
               
               
                   
                   
                   
                 protein 2 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 200021_at 
                 NM_005507 
                 CFL1 
                 cofilin 1 (non- 
                 0.0039 
                 0.1498 
                 −1.3 
               
               
                   
                   
                   
                 muscle) /// cofilin 1 
                   
                   
                   
               
               
                   
                   
                   
                 (non-muscle) 
                   
                   
                   
               
               
                 201968_s_at 
                 NM_002633 
                 PGM1 
                 phosphoglucomutase 1 
                 0.0049 
                 0.2714 
                 −1.3 
               
               
                 202593_s_at 
                 NM_016641 
                 MIR16 
                 membrane 
                 0.0177 
                 0.1789 
                 −1.3 
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                   
                 of RGS16 
                   
                   
                   
               
               
                 200918_s_at 
                 NM_003139 
                 SRPR 
                 signal recognition 
                 0.0112 
                 0.3210 
                 −1.3 
               
               
                   
                   
                   
                 particle receptor 
                   
                   
                   
               
               
                   
                   
                   
                 (‘docking protein’) 
                   
                   
                   
               
               
                 204238_s_at 
                 NM_006443 
                 C6orf108 
                 chromosome 6 
                 0.0494 
                 0.8953 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 108 
                   
                   
                   
               
               
                 201704_at 
                 NM_001247 
                 ENTPD6 
                 ectonucleoside 
                 0.0358 
                 0.5222 
                 −1.3 
               
               
                   
                   
                   
                 triphosphate 
                   
                   
                   
               
               
                   
                   
                   
                 diphosphohydrolase 
                   
                   
                   
               
               
                   
                   
                   
                 6 (putative 
                   
                   
                   
               
               
                   
                   
                   
                 function) 
                   
                   
                   
               
               
                 201267_s_at 
                 AL545523 
                 PSMC3 
                 proteasome 
                 0.0010 
                 0.7722 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, ATPase, 3 
                   
                   
                   
               
               
                 201923_at 
                 NM_006406 
                 PRDX4 
                 peroxiredoxin 4 
                 0.0044 
                 0.0475 
                 −1.3 
               
               
                 211065_x_at 
                 BC006422 
                 PFKL 
                 phosphofructokinase, 
                 0.0056 
                 0.1200 
                 −1.3 
               
               
                   
                   
                   
                 liver /// 
                   
                   
                   
               
               
                   
                   
                   
                 phosphofructokinase, 
                   
                   
                   
               
               
                   
                   
                   
                 liver 
                   
                   
                   
               
               
                 205002_at 
                 NM_015699 
                 AHDC1 
                 AT hook, DNA 
                 0.0301 
                 0.6324 
                 −1.3 
               
               
                   
                   
                   
                 binding motif, 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 218529_at 
                 NM_016579 
                 CD320 
                 CD320 molecule 
                 0.0027 
                 0.2776 
                 −1.3 
               
               
                 200640_at 
                 NM_003406 
                 YWHAZ 
                 tyrosine 3- 
                 0.0023 
                 0.1580 
                 −1.3 
               
               
                   
                   
                   
                 monooxygenase/tryptophan 
                   
                   
                   
               
               
                   
                   
                   
                 5- 
                   
                   
                   
               
               
                   
                   
                   
                 monooxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 activation protein, 
                   
                   
                   
               
               
                   
                   
                   
                 zeta polypeptide 
                   
                   
                   
               
               
                 37384_at 
                 D86995 
                 PPM1F 
                 protein 
                 0.0244 
                 0.7220 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase 1F 
                   
                   
                   
               
               
                   
                   
                   
                 (PP2C domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing) 
                   
                   
                   
               
               
                 210678_s_at 
                 U56418 
                 AGPAT2 
                 1-acylglycerol-3- 
                 0.0380 
                 0.8549 
                 −1.3 
               
               
                   
                   
                   
                 phosphate O- 
                   
                   
                   
               
               
                   
                   
                   
                 acyltransferase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (lysophosphatidic 
                   
                   
                   
               
               
                   
                   
                   
                 acid 
                   
                   
                   
               
               
                   
                   
                   
                 acyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 beta) 
                   
                   
                   
               
               
                 218399_s_at 
                 NM_017955 
                 CDCA4 
                 cell division cycle 
                 0.0012 
                 0.5384 
                 −1.3 
               
               
                   
                   
                   
                 associated 4 
                   
                   
                   
               
               
                 203201_at 
                 NM_000303 
                 PMM2 
                 phosphomannomutase 2 
                 0.0020 
                 0.4099 
                 −1.3 
               
               
                 212829_at 
                 BE878277 
                 — 
                 CDNA FLJ13267 
                 0.0007 
                 0.0383 
                 −1.3 
               
               
                   
                   
                   
                 fis, clone 
                   
                   
                   
               
               
                   
                   
                   
                 OVARC1000964 
                   
                   
                   
               
               
                   
                   
                   
                 /// CDNA 
                   
                   
                   
               
               
                   
                   
                   
                 FLJ13267 fis, 
                   
                   
                   
               
               
                   
                   
                   
                 clone 
                   
                   
                   
               
               
                   
                   
                   
                 OVARC1000964 
                   
                   
                   
               
               
                 214119_s_at 
                 AI936769 
                 FKBP1A 
                 FK506 binding 
                 0.0045 
                 0.0911 
                 −1.3 
               
               
                   
                   
                   
                 protein 1A, 12 kDa 
                   
                   
                   
               
               
                 215696_s_at 
                 BC001404 
                 KIAA0310 
                 KIAA0310 
                 0.0039 
                 0.2613 
                 −1.3 
               
               
                 200020_at 
                 NM_007375 
                 TARDBP 
                 TAR DNA binding 
                 0.0031 
                 0.1467 
                 −1.3 
               
               
                   
                   
                   
                 protein /// TAR 
                   
                   
                   
               
               
                   
                   
                   
                 DNA binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212723_at 
                 AK021780 
                 PTDSR 
                 phosphatidylserine 
                 0.0091 
                 0.1709 
                 −1.3 
               
               
                   
                   
                   
                 receptor 
                   
                   
                   
               
               
                 218890_x_at 
                 NM_016622 
                 MRPL35 
                 mitochondrial 
                 0.0170 
                 0.7931 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L35 
                   
                   
                   
               
               
                 201577_at 
                 NM_000269 
                 NME1 
                 non-metastatic 
                 0.0007 
                 0.0699 
                 −1.3 
               
               
                   
                   
                   
                 cells 1, protein 
                   
                   
                   
               
               
                   
                   
                   
                 (NM23A) 
                   
                   
                   
               
               
                   
                   
                   
                 expressed in 
                   
                   
                   
               
               
                 205740_s_at 
                 NM_024321 
                 MGC10433 
                 hypothetical 
                 0.0094 
                 0.3321 
                 −1.3 
               
               
                   
                   
                   
                 protein MGC10433 
                   
                   
                   
               
               
                 221807_s_at 
                 BG399562 
                 TRABD 
                 TraB domain 
                 0.0359 
                 0.5498 
                 −1.3 
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                 217947_at 
                 NM_017801 
                 CMTM6 
                 CKLF-like 
                 0.0187 
                 0.1774 
                 −1.3 
               
               
                   
                   
                   
                 MARVEL 
                   
                   
                   
               
               
                   
                   
                   
                 transmembrane 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 6 
                   
                   
                   
               
               
                 202934_at 
                 AI761561 
                 HK2 
                 hexokinase 2 
                 0.0265 
                 0.1646 
                 −1.3 
               
               
                 214726_x_at 
                 AL556041 
                 ADD1 
                 adducin 1 (alpha) 
                 0.0175 
                 0.0771 
                 −1.3 
               
               
                 204328_at 
                 NM_007267 
                 TMC6 
                 transmembrane 
                 0.0245 
                 0.6147 
                 −1.3 
               
               
                   
                   
                   
                 channel-like 6 
                   
                   
                   
               
               
                 47069_at 
                 AA533284 
                 PRR5 
                 proline rich 5 
                 0.0045 
                 0.0714 
                 −1.3 
               
               
                   
                   
                   
                 (renal) 
                   
                   
                   
               
               
                 200830_at 
                 NM_002808 
                 PSMD2 
                 proteasome 
                 0.0024 
                 0.1174 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, non- 
                   
                   
                   
               
               
                   
                   
                   
                 ATPase, 2 
                   
                   
                   
               
               
                 208858_s_at 
                 BC004998 
                 FAM62A 
                 family with 
                 0.0154 
                 0.5500 
                 −1.3 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 62 (C2 domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing), 
                   
                   
                   
               
               
                   
                   
                   
                 member A 
                   
                   
                   
               
               
                 218596_at 
                 NM_018201 
                 TBC1D13 
                 TBC1 domain 
                 0.0433 
                 0.2850 
                 −1.3 
               
               
                   
                   
                   
                 family, member 13 
                   
                   
                   
               
               
                 212016_s_at 
                 AA679988 
                 PTBP1 
                 polypyrimidine 
                 0.0124 
                 0.0659 
                 −1.3 
               
               
                   
                   
                   
                 tract binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 202870_s_at 
                 NM_001255 
                 CDC20 
                 cell division cycle 
                 0.0117 
                 0.1758 
                 −1.3 
               
               
                   
                   
                   
                 20 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209714_s_at 
                 AF213033 
                 CDKN3 
                 cyclin-dependent 
                 0.0069 
                 0.7689 
                 −1.3 
               
               
                   
                   
                   
                 kinase inhibitor 3 
                   
                   
                   
               
               
                   
                   
                   
                 (CDK2-associated 
                   
                   
                   
               
               
                   
                   
                   
                 dual specificity 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatase) 
                   
                   
                   
               
               
                 219051_x_at 
                 NM_024042 
                 METRN 
                 meteorin, glial cell 
                 0.0107 
                 0.9563 
                 −1.3 
               
               
                   
                   
                   
                 differentiation 
                   
                   
                   
               
               
                   
                   
                   
                 regulator 
                   
                   
                   
               
               
                 209365_s_at 
                 U65932 
                 ECM1 
                 extracellular matrix 
                 0.0232 
                 0.1288 
                 −1.3 
               
               
                   
                   
                   
                 protein 1 
                   
                   
                   
               
               
                 202535_at 
                 NM_003824 
                 FADD 
                 Fas (TNFRSF6)- 
                 0.0366 
                 0.8980 
                 −1.3 
               
               
                   
                   
                   
                 associated via 
                   
                   
                   
               
               
                   
                   
                   
                 death domain 
                   
                   
                   
               
               
                 202836_s_at 
                 NM_006701 
                 TXNL4A 
                 thioredoxin-like 
                 0.0069 
                 0.3942 
                 −1.3 
               
               
                   
                   
                   
                 4A 
                   
                   
                   
               
               
                 217811_at 
                 NM_016275 
                 SELT 
                 selenoprotein T 
                 0.0314 
                 0.2573 
                 −1.3 
               
               
                 211505_s_at 
                 AL136601 
                 STAU1 
                 staufen, RNA 
                 0.0378 
                 0.6525 
                 −1.3 
               
               
                   
                   
                   
                 binding protein, 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 203664_s_at 
                 NM_004805 
                 POLR2D 
                 polymerase (RNA) 
                 0.0204 
                 0.3117 
                 −1.3 
               
               
                   
                   
                   
                 II (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide D 
                   
                   
                   
               
               
                 218291_at 
                 NM_014017 
                 MAPBPIP 
                 mitogen-activated 
                 0.0034 
                 0.3392 
                 −1.3 
               
               
                   
                   
                   
                 protein-binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein-interacting 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 212858_at 
                 AL520675 
                 PAQR4 
                 progestin and 
                 0.0060 
                 0.2961 
                 −1.3 
               
               
                   
                   
                   
                 adipoQ receptor 
                   
                   
                   
               
               
                   
                   
                   
                 family member IV 
                   
                   
                   
               
               
                 218391_at 
                 NM_007241 
                 SNF8 
                 SNF8, ESCRT-II 
                 0.0056 
                 0.3662 
                 −1.3 
               
               
                   
                   
                   
                 complex subunit, 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 201724_s_at 
                 NM_020474 
                 GALNT1 
                 UDP-N-acetyl- 
                 0.0073 
                 0.0441 
                 −1.3 
               
               
                   
                   
                   
                 alpha-D- 
                   
                   
                   
               
               
                   
                   
                   
                 galactosamine:poly 
                   
                   
                   
               
               
                   
                   
                   
                 peptide N- 
                   
                   
                   
               
               
                   
                   
                   
                 acetylgalactosaminyltransferase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (GalNAc-T1) 
                   
                   
                   
               
               
                 200699_at 
                 BE962456 
                 — 
                 Full-length cDNA 
                 0.0042 
                 0.6171 
                 −1.3 
               
               
                   
                   
                   
                 clone 
                   
                   
                   
               
               
                   
                   
                   
                 CS0DC014YA20 
                   
                   
                   
               
               
                   
                   
                   
                 of Neuroblastoma 
                   
                   
                   
               
               
                   
                   
                   
                 Cot 25-normalized 
                   
                   
                   
               
               
                   
                   
                   
                 of  Homo sapiens   
                   
                   
                   
               
               
                   
                   
                   
                 (human) 
                   
                   
                   
               
               
                 221436_s_at 
                 NM_031299 
                 CDCA3 
                 cell division cycle 
                 0.0140 
                 0.1080 
                 −1.3 
               
               
                   
                   
                   
                 associated 3 /// cell 
                   
                   
                   
               
               
                   
                   
                   
                 division cycle 
                   
                   
                   
               
               
                   
                   
                   
                 associated 3 
                   
                   
                   
               
               
                 204174_at 
                 NM_001629 
                 ALOX5AP 
                 arachidonate 5- 
                 0.0219 
                 0.4380 
                 −1.3 
               
               
                   
                   
                   
                 lipoxygenase- 
                   
                   
                   
               
               
                   
                   
                   
                 activating protein 
                   
                   
                   
               
               
                 212170_at 
                 BF447705 
                 RBM12 
                 RNA binding motif 
                 0.0244 
                 0.1083 
                 −1.3 
               
               
                   
                   
                   
                 protein 12 
                   
                   
                   
               
               
                 217911_s_at 
                 NM_004281 
                 BAG3 
                 BCL2-associated 
                 0.0428 
                 0.7171 
                 −1.3 
               
               
                   
                   
                   
                 athanogene 3 
                   
                   
                   
               
               
                 208445_s_at 
                 NM_023005 
                 BAZ1B 
                 bromodomain 
                 0.0085 
                 0.7292 
                 −1.3 
               
               
                   
                   
                   
                 adjacent to zinc 
                   
                   
                   
               
               
                   
                   
                   
                 finger domain, 1B 
                   
                   
                   
               
               
                 221692_s_at 
                 AB049652 
                 MRPL34 
                 mitochondrial 
                 0.0399 
                 0.4826 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 /// 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L34 
                   
                   
                   
               
               
                 218555_at 
                 NM_013366 
                 ANAPC2 
                 anaphase 
                 0.0039 
                 0.0274 
                 −1.3 
               
               
                   
                   
                   
                 promoting complex 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 2 
                   
                   
                   
               
               
                 219203_at 
                 NM_016049 
                 C14orf122 
                 chromosome 14 
                 0.0005 
                 0.0911 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 122 
                   
                   
                   
               
               
                 220948_s_at 
                 NM_000701 
                 ATP1A1 
                 ATPase, Na+/K+ 
                 0.0107 
                 0.3441 
                 −1.3 
               
               
                   
                   
                   
                 transporting, alpha 
                   
                   
                   
               
               
                   
                   
                   
                 1 polypeptide 
                   
                   
                   
               
               
                 201376_s_at 
                 AI591354 
                 HNRPF 
                 heterogeneous 
                 0.0101 
                 0.3926 
                 −1.3 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein F 
                   
                   
                   
               
               
                 204133_at 
                 NM_004704 
                 RRP9 
                 RRP9, small 
                 0.0445 
                 0.6616 
                 −1.3 
               
               
                   
                   
                   
                 subunit (SSU) 
                   
                   
                   
               
               
                   
                   
                   
                 processome 
                   
                   
                   
               
               
                   
                   
                   
                 component, 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 201903_at 
                 NM_003365 
                 UQCRC1 
                 ubiquinol- 
                 0.0085 
                 0.2404 
                 −1.3 
               
               
                   
                   
                   
                 cytochrome c 
                   
                   
                   
               
               
                   
                   
                   
                 reductase core 
                   
                   
                   
               
               
                   
                   
                   
                 protein I 
                   
                   
                   
               
               
                 205241_at 
                 NM_005138 
                 SCO2 
                 SCO cytochrome 
                 0.0071 
                 0.3412 
                 −1.3 
               
               
                   
                   
                   
                 oxidase deficient 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 2 (yeast) 
                   
                   
                   
               
               
                 200799_at 
                 NM_005345 
                 HSPA1A 
                 heat shock 70 kDa 
                 0.0253 
                 0.0476 
                 −1.3 
               
               
                   
                   
                   
                 protein 1A 
                   
                   
                   
               
               
                 218317_x_at 
                 NM_024044 
                 GIYD2 /// 
                 GIY-YIG domain 
                 0.0033 
                 0.0441 
                 −1.3 
               
               
                   
                   
                 GIYD1 
                 containing 2 /// 
                   
                   
                   
               
               
                   
                   
                   
                 GIY-YIG domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 209836_x_at 
                 AF060511 
                 BOLA2 /// 
                 bolA homolog 2 
                 0.0027 
                 0.0592 
                 −1.3 
               
               
                   
                   
                 BOLA2B 
                 ( E. coli ) /// bolA 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 2B ( E. coli ) 
                   
                   
                   
               
               
                 213244_at 
                 AI207792 
                 SCAMP4 
                 secretory carrier 
                 0.0242 
                 0.1143 
                 −1.3 
               
               
                   
                   
                   
                 membrane protein 4 
                   
                   
                   
               
               
                 201662_s_at 
                 D89053 
                 ACSL3 
                 acyl-CoA 
                 0.0245 
                 0.9280 
                 −1.3 
               
               
                   
                   
                   
                 synthetase long- 
                   
                   
                   
               
               
                   
                   
                   
                 chain family 
                   
                   
                   
               
               
                   
                   
                   
                 member 3 
                   
                   
                   
               
               
                 206554_x_at 
                 NM_006515 
                 SETMAR 
                 SET domain and 
                 0.0298 
                 0.4143 
                 −1.3 
               
               
                   
                   
                   
                 mariner 
                   
                   
                   
               
               
                   
                   
                   
                 transposase fusion 
                   
                   
                   
               
               
                   
                   
                   
                 gene 
                   
                   
                   
               
               
                 203925_at 
                 NM_002061 
                 GCLM 
                 glutamate-cysteine 
                 0.0146 
                 0.1594 
                 −1.3 
               
               
                   
                   
                   
                 ligase, modifier 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                 200707_at 
                 NM_002743 
                 PRKCSH 
                 protein kinase C 
                 0.0194 
                 0.0567 
                 −1.3 
               
               
                   
                   
                   
                 substrate 80K-H 
                   
                   
                   
               
               
                 201963_at 
                 NM_021122 
                 ACSL1 
                 acyl-CoA 
                 0.0149 
                 0.3605 
                 −1.3 
               
               
                   
                   
                   
                 synthetase long- 
                   
                   
                   
               
               
                   
                   
                   
                 chain family 
                   
                   
                   
               
               
                   
                   
                   
                 member 1 
                   
                   
                   
               
               
                 207856_s_at 
                 NM_017951 
                 SMPD4 /// 
                 sphingomyelin 
                 0.0201 
                 0.6155 
                 −1.3 
               
               
                   
                   
                 FLJ41352 
                 phosphodiesterase 
                   
                   
                   
               
               
                   
                   
                   
                 4, neutral 
                   
                   
                   
               
               
                   
                   
                   
                 membrane (neutral 
                   
                   
                   
               
               
                   
                   
                   
                 sphingomyelinase- 
                   
                   
                   
               
               
                   
                   
                   
                 3) /// FLJ41352 
                   
                   
                   
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 200875_s_at 
                 NM_006392 
                 NOL5A 
                 nucleolar protein 
                 0.0031 
                 0.4776 
                 −1.3 
               
               
                   
                   
                   
                 5A (56 kDa with 
                   
                   
                   
               
               
                   
                   
                   
                 KKE/D repeat) 
                   
                   
                   
               
               
                 202382_s_at 
                 NM_005471 
                 GNPDA1 
                 glucosamine-6- 
                 0.0070 
                 0.7544 
                 −1.3 
               
               
                   
                   
                   
                 phosphate 
                   
                   
                   
               
               
                   
                   
                   
                 deaminase 1 
                   
                   
                   
               
               
                 203017_s_at 
                 R52678 
                 SSX2IP 
                 synovial sarcoma, 
                 0.0205 
                 0.5419 
                 −1.3 
               
               
                   
                   
                   
                 X breakpoint 2 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 208702_x_at 
                 AI525212 
                 APLP2 
                 amyloid beta (A4) 
                 0.0122 
                 0.2960 
                 −1.3 
               
               
                   
                   
                   
                 precursor-like 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 201764_at 
                 NM_024056 
                 TMEM106C 
                 transmembrane 
                 0.0019 
                 0.0834 
                 −1.3 
               
               
                   
                   
                   
                 protein 106C 
                   
                   
                   
               
               
                 221521_s_at 
                 BC003186 
                 GINS2 
                 GINS complex 
                 0.0045 
                 0.2979 
                 −1.3 
               
               
                   
                   
                   
                 subunit 2 (Psf2 
                   
                   
                   
               
               
                   
                   
                   
                 homolog) 
                   
                   
                   
               
               
                 216971_s_at 
                 Z54367 
                 PLEC1 
                 plectin 1, 
                 0.0037 
                 0.0894 
                 −1.3 
               
               
                   
                   
                   
                 intermediate 
                   
                   
                   
               
               
                   
                   
                   
                 filament binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein 500 kDa 
                   
                   
                   
               
               
                 217893_s_at 
                 NM_024595 
                 C1orf108 
                 chromosome 1 
                 0.0435 
                 0.0434 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 108 
                   
                   
                   
               
               
                 219709_x_at 
                 NM_023933 
                 C16orf24 
                 chromosome 16 
                 0.0166 
                 0.3879 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 24 
                   
                   
                   
               
               
                 205401_at 
                 NM_003659 
                 AGPS 
                 alkylglycerone 
                 0.0355 
                 0.3570 
                 −1.3 
               
               
                   
                   
                   
                 phosphate synthase 
                   
                   
                   
               
               
                 209017_s_at 
                 U02389 
                 LONP1 
                 lon peptidase 1, 
                 0.0368 
                 0.7567 
                 −1.3 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 221815_at 
                 BE671816 
                 ABHD2 
                 abhydrolase 
                 0.0233 
                 0.7423 
                 −1.3 
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 208972_s_at 
                 AL080089 
                 ATP5G1 
                 ATP synthase, H+ 
                 0.0066 
                 0.4128 
                 −1.3 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial F0 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 C1 (subunit 9) 
                   
                   
                   
               
               
                 213052_at 
                 BF246917 
                 PRKAR2A 
                 Protein kinase, 
                 0.0180 
                 0.8806 
                 −1.3 
               
               
                   
                   
                   
                 cAMP-dependent, 
                   
                   
                   
               
               
                   
                   
                   
                 regulatory, type II, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 208676_s_at 
                 U87954 
                 DLST /// 
                 dihydrolipoamide 
                 0.0016 
                 0.3528 
                 −1.3 
               
               
                   
                   
                 PA2G4 
                 S- 
                   
                   
                   
               
               
                   
                   
                   
                 succinyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (E2 component of 
                   
                   
                   
               
               
                   
                   
                   
                 2-oxo-glutarate 
                   
                   
                   
               
               
                   
                   
                   
                 complex) /// 
                   
                   
                   
               
               
                   
                   
                   
                 proliferation- 
                   
                   
                   
               
               
                   
                   
                   
                 associated 2G4, 
                   
                   
                   
               
               
                   
                   
                   
                 38 kDa 
                   
                   
                   
               
               
                 210672_s_at 
                 BC004185 
                 C16orf35 
                 chromosome 16 
                 0.0151 
                 0.2049 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 35 
                   
                   
                   
               
               
                 204766_s_at 
                 NM_002452 
                 NUDT1 
                 nudix (nucleoside 
                 0.0048 
                 0.3257 
                 −1.3 
               
               
                   
                   
                   
                 diphosphate linked 
                   
                   
                   
               
               
                   
                   
                   
                 moiety X)-type 
                   
                   
                   
               
               
                   
                   
                   
                 motif 1 
                   
                   
                   
               
               
                 208270_s_at 
                 NM_020216 
                 RNPEP 
                 arginyl 
                 0.0183 
                 0.2672 
                 −1.3 
               
               
                   
                   
                   
                 aminopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 (aminopeptidase B) 
                   
                   
                   
               
               
                 213937_s_at 
                 AV723177 
                 FTSJ1 
                 FtsJ homolog 1 ( E. coli ) 
                 0.0436 
                 0.9574 
                 −1.3 
               
               
                 209444_at 
                 BC001851 
                 RAP1GDS1 
                 RAP1, GTP-GDP 
                 0.0280 
                 0.4171 
                 −1.3 
               
               
                   
                   
                   
                 dissociation 
                   
                   
                   
               
               
                   
                   
                   
                 stimulator 1 
                   
                   
                   
               
               
                 211071_s_at 
                 BC006471 
                 MLLT11 
                 myeloid/lymphoid 
                 0.0021 
                 0.0418 
                 −1.3 
               
               
                   
                   
                   
                 or mixed-lineage 
                   
                   
                   
               
               
                   
                   
                   
                 leukemia (trithorax 
                   
                   
                   
               
               
                   
                   
                   
                 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 
                   Drosophila); 
                 
                   
                   
                   
               
               
                   
                   
                   
                 translocated to, 11 
                   
                   
                   
               
               
                   
                   
                   
                 /// 
                   
                   
                   
               
               
                   
                   
                   
                 myeloid/lymphoid 
                   
                   
                   
               
               
                   
                   
                   
                 or mixed-lineage 
                   
                   
                   
               
               
                   
                   
                   
                 leukemia (trithorax 
                   
                   
                   
               
               
                   
                   
                   
                 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 
                   Drosophila); 
                 
                   
                   
                   
               
               
                   
                   
                   
                 translocated to, 11 
                   
                   
                   
               
               
                 200637_s_at 
                 AI762627 
                 PTPRF 
                 protein tyrosine 
                 0.0406 
                 0.2980 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase, 
                   
                   
                   
               
               
                   
                   
                   
                 receptor type, F 
                   
                   
                   
               
               
                 202475_at 
                 NM_006326 
                 TMEM147 
                 transmembrane 
                 0.0016 
                 0.4204 
                 −1.3 
               
               
                   
                   
                   
                 protein 147 
                   
                   
                   
               
               
                 221647_s_at 
                 AL136935 
                 RIC8A 
                 resistance to 
                 0.0132 
                 0.5700 
                 −1.3 
               
               
                   
                   
                   
                 inhibitors of 
                   
                   
                   
               
               
                   
                   
                   
                 cholinesterase 8 
                   
                   
                   
               
               
                   
                   
                   
                 homolog A ( C. elegans ) 
                   
                   
                   
               
               
                 204169_at 
                 NM_000883 
                 IMPDH1 
                 IMP (inosine 
                 0.0287 
                 0.3633 
                 −1.3 
               
               
                   
                   
                   
                 monophosphate) 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 1 
                   
                   
                   
               
               
                 216969_s_at 
                 AC002301 
                 KIF22 /// 
                 kinesin family 
                 0.0355 
                 0.0578 
                 −1.3 
               
               
                   
                   
                 LOC728037 
                 member 22 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to Kinesin- 
                   
                   
                   
               
               
                   
                   
                   
                 like protein KIF22 
                   
                   
                   
               
               
                   
                   
                   
                 (Kinesin-like 
                   
                   
                   
               
               
                   
                   
                   
                 DNA-binding 
                   
                   
                   
               
               
                   
                   
                   
                 protein) (Kinesin- 
                   
                   
                   
               
               
                   
                   
                   
                 like protein 4) 
                   
                   
                   
               
               
                 202459_s_at 
                 U55968 
                 LPIN2 
                 lipin 2 
                 0.0083 
                 0.3844 
                 −1.3 
               
               
                 204306_s_at 
                 NM_004357 
                 CD151 
                 CD151 molecule 
                 0.0015 
                 0.0558 
                 −1.3 
               
               
                   
                   
                   
                 (Raph blood group) 
                   
                   
                   
               
               
                 218550_s_at 
                 NM_018205 
                 LRRC20 
                 leucine rich repeat 
                 0.0145 
                 0.3547 
                 −1.3 
               
               
                   
                   
                   
                 containing 20 
                   
                   
                   
               
               
                 201388_at 
                 NM_002809 
                 PSMD3 
                 proteasome 
                 0.0015 
                 0.0524 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, non- 
                   
                   
                   
               
               
                   
                   
                   
                 ATPase, 3 
                   
                   
                   
               
               
                 212971_at 
                 AI769685 
                 CARS 
                 cysteinyl-tRNA 
                 0.0007 
                 0.0665 
                 −1.3 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 200072_s_at 
                 AF061832 
                 HNRPM 
                 heterogeneous 
                 0.0049 
                 0.2084 
                 −1.3 
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 M /// 
                   
                   
                   
               
               
                   
                   
                   
                 heterogeneous 
                   
                   
                   
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein M 
                   
                   
                   
               
               
                 218420_s_at 
                 NM_025138 
                 C13orf23 
                 chromosome 13 
                 0.0134 
                 0.2363 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 23 
                   
                   
                   
               
               
                 218408_at 
                 NM_012456 
                 TIMM10 
                 translocase of inner 
                 0.0149 
                 0.4352 
                 −1.3 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 membrane 10 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 217973_at 
                 NM_016286 
                 DCXR 
                 dicarbonyl/L- 
                 0.0025 
                 0.0732 
                 −1.3 
               
               
                   
                   
                   
                 xylulose reductase 
                   
                   
                   
               
               
                 204033_at 
                 NM_004237 
                 TRIP13 
                 thyroid hormone 
                 0.0084 
                 0.7000 
                 −1.3 
               
               
                   
                   
                   
                 receptor interactor 
                   
                   
                   
               
               
                   
                   
                   
                 13 
                   
                   
                   
               
               
                 217871_s_at 
                 NM_002415 
                 MIF 
                 macrophage 
                 0.0050 
                 0.1736 
                 −1.3 
               
               
                   
                   
                   
                 migration 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitory factor 
                   
                   
                   
               
               
                   
                   
                   
                 (glycosylation- 
                   
                   
                   
               
               
                   
                   
                   
                 inhibiting factor) 
                   
                   
                   
               
               
                 201932_at 
                 NM_006369 
                 LRRC41 
                 leucine rich repeat 
                 0.0294 
                 0.5384 
                 −1.3 
               
               
                   
                   
                   
                 containing 41 
                   
                   
                   
               
               
                 217923_at 
                 NM_012392 
                 PEF1 
                 penta-EF-hand 
                 0.0170 
                 0.2047 
                 −1.3 
               
               
                   
                   
                   
                 domain containing 1 
                   
                   
                   
               
               
                 211595_s_at 
                 AB049944 
                 MRPS11 
                 mitochondrial 
                 0.0027 
                 0.2091 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S11 /// 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S11 
                   
                   
                   
               
               
                 213041_s_at 
                 BE798517 
                 ATP5D 
                 ATP synthase, H+ 
                 0.0053 
                 0.2420 
                 −1.3 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial F1 
                   
                   
                   
               
               
                   
                   
                   
                 complex, delta 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                 212219_at 
                 D38521 
                 PSME4 
                 proteasome 
                 0.0245 
                 0.5016 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 activator subunit 4 
                   
                   
                   
               
               
                 200654_at 
                 J02783 
                 P4HB /// 
                 procollagen- 
                 0.0151 
                 0.0856 
                 −1.3 
               
               
                   
                   
                 LOC728900 
                 proline, 2- 
                   
                   
                   
               
               
                   
                   
                   
                 oxoglutarate 4- 
                   
                   
                   
               
               
                   
                   
                   
                 dioxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 (proline 4- 
                   
                   
                   
               
               
                   
                   
                   
                 hydroxylase), beta 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to prolyl 4- 
                   
                   
                   
               
               
                   
                   
                   
                 hydroxylase, beta 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 
                   
                   
                   
               
               
                 219997_s_at 
                 NM_022730 
                 COPS7B 
                 COP9 constitutive 
                 0.0166 
                 0.3902 
                 −1.3 
               
               
                   
                   
                   
                 photomorphogenic 
                   
                   
                   
               
               
                   
                   
                   
                 homolog subunit 
                   
                   
                   
               
               
                   
                   
                   
                 7B ( Arabidopsis ) 
                   
                   
                   
               
               
                 201014_s_at 
                 NM_006452 
                 PAICS 
                 phosphoribosylaminoimidazole 
                 0.0484 
                 0.3181 
                 −1.3 
               
               
                   
                   
                   
                 carboxylase, 
                   
                   
                   
               
               
                   
                   
                   
                 phosphoribosylaminoimidazole 
                   
                   
                   
               
               
                   
                   
                   
                 succinocarboxamide 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 200954_at 
                 NM_001694 
                 ATP6V0C 
                 ATPase, H+ 
                 0.0248 
                 0.1232 
                 −1.3 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 lysosomal 16 kDa, 
                   
                   
                   
               
               
                   
                   
                   
                 V0 subunit c 
                   
                   
                   
               
               
                 219047_s_at 
                 NM_024706 
                 ZNF668 
                 zinc finger protein 
                 0.0026 
                 0.5284 
                 −1.3 
               
               
                   
                   
                   
                 668 
                   
                   
                   
               
               
                 210125_s_at 
                 AF044773 
                 BANF1 
                 barrier to 
                 0.0006 
                 0.0721 
                 −1.3 
               
               
                   
                   
                   
                 autointegration 
                   
                   
                   
               
               
                   
                   
                   
                 factor 1 
                   
                   
                   
               
               
                 205439_at 
                 NM_000854 
                 GSTT2 
                 glutathione S- 
                 0.0203 
                 0.3127 
                 −1.3 
               
               
                   
                   
                   
                 transferase theta 2 
                   
                   
                   
               
               
                 218394_at 
                 NM_024589 
                 ROGDI 
                 rogdi homolog 
                 0.0020 
                 0.0424 
                 −1.3 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 217934_x_at 
                 NM_005861 
                 STUB1 
                 STIP1 homology 
                 0.0049 
                 0.2833 
                 −1.3 
               
               
                   
                   
                   
                 and U-box 
                   
                   
                   
               
               
                   
                   
                   
                 containing protein 1 
                   
                   
                   
               
               
                 218141_at 
                 NM_022066 
                 UBE2O 
                 ubiquitin- 
                 0.0077 
                 0.0895 
                 −1.3 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2O 
                   
                   
                   
               
               
                 221575_at 
                 BC000586 
                 SCLY 
                 selenocysteine 
                 0.0435 
                 0.4733 
                 −1.3 
               
               
                   
                   
                   
                 lyase 
                   
                   
                   
               
               
                 218447_at 
                 NM_020188 
                 C16orf61 
                 chromosome 16 
                 0.0336 
                 0.1746 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 61 
                   
                   
                   
               
               
                 212456_at 
                 AB014564 
                 KIAA0664 
                 KIAA0664 
                 0.0143 
                 0.8617 
                 −1.3 
               
               
                 202308_at 
                 NM_004176 
                 SREBF1 
                 sterol regulatory 
                 0.0441 
                 0.3563 
                 −1.3 
               
               
                   
                   
                   
                 element binding 
                   
                   
                   
               
               
                   
                   
                   
                 transcription factor 1 
                   
                   
                   
               
               
                 217782_s_at 
                 NM_004127 
                 GPS1 
                 G protein pathway 
                 0.0186 
                 0.1542 
                 −1.3 
               
               
                   
                   
                   
                 suppressor 1 
                   
                   
                   
               
               
                 208978_at 
                 U36190 
                 CRIP2 
                 cysteine-rich 
                 0.0014 
                 0.0604 
                 −1.3 
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 212767_at 
                 BC004409 
                 MTG1 
                 mitochondrial 
                 0.0015 
                 0.0547 
                 −1.3 
               
               
                   
                   
                   
                 GTPase 1 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 202236_s_at 
                 NM_003051 
                 SLC16A1 
                 solute carrier 
                 0.0046 
                 0.1925 
                 −1.3 
               
               
                   
                   
                   
                 family 16, member 
                   
                   
                   
               
               
                   
                   
                   
                 1 (monocarboxylic 
                   
                   
                   
               
               
                   
                   
                   
                 acid transporter 1) 
                   
                   
                   
               
               
                 222118_at 
                 AK023669 
                 CENPN 
                 centromere protein N 
                 0.0487 
                 0.5572 
                 −1.3 
               
               
                 204027_s_at 
                 NM_005371 
                 METTL1 
                 methyltransferase 
                 0.0329 
                 0.3662 
                 −1.3 
               
               
                   
                   
                   
                 like 1 
                   
                   
                   
               
               
                 204514_at 
                 NM_001384 
                 DPH2 
                 DPH2 homolog ( S. cerevisiae ) 
                 0.0114 
                 0.1875 
                 −1.3 
               
               
                 218565_at 
                 BG223334 
                 C9orf114 
                 chromosome 9 
                 0.0037 
                 0.0721 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 114 
                   
                   
                   
               
               
                 202860_at 
                 NM_014856 
                 DENND4B 
                 DENN/MADD 
                 0.0043 
                 0.0285 
                 −1.3 
               
               
                   
                   
                   
                 domain containing 
                   
                   
                   
               
               
                   
                   
                   
                 4B 
                   
                   
                   
               
               
                 205085_at 
                 NM_004153 
                 ORC1L 
                 origin recognition 
                 0.0423 
                 0.8149 
                 −1.3 
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 1-like (yeast) 
                   
                   
                   
               
               
                 209191_at 
                 BC002654 
                 TUBB6 
                 tubulin, beta 6 
                 0.0018 
                 0.6584 
                 −1.3 
               
               
                 213730_x_at 
                 BE962186 
                 TCF3 
                 transcription factor 
                 0.0021 
                 0.5366 
                 −1.3 
               
               
                   
                   
                   
                 3 (E2A 
                   
                   
                   
               
               
                   
                   
                   
                 immunoglobulin 
                   
                   
                   
               
               
                   
                   
                   
                 enhancer binding 
                   
                   
                   
               
               
                   
                   
                   
                 factors E12/E47) 
                   
                   
                   
               
               
                 203612_at 
                 NM_004053 
                 BYSL 
                 bystin-like 
                 0.0126 
                 0.6728 
                 −1.3 
               
               
                 219068_x_at 
                 NM_018188 
                 ATAD3A 
                 ATPase family, 
                 0.0127 
                 0.3312 
                 −1.3 
               
               
                   
                   
                   
                 AAA domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 3A 
                   
                   
                   
               
               
                 205444_at 
                 NM_004320 
                 ATP2A1 
                 ATPase, Ca++ 
                 0.0427 
                 0.1270 
                 −1.3 
               
               
                   
                   
                   
                 transporting, 
                   
                   
                   
               
               
                   
                   
                   
                 cardiac muscle, fast 
                   
                   
                   
               
               
                   
                   
                   
                 twitch 1 
                   
                   
                   
               
               
                 204817_at 
                 NM_012291 
                 ESPL1 
                 extra spindle pole 
                 0.0293 
                 0.0418 
                 −1.3 
               
               
                   
                   
                   
                 bodies homolog 1 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 208973_at 
                 BC001072 
                 PRNPIP 
                 prion protein 
                 0.0077 
                 0.3586 
                 −1.3 
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 202055_at 
                 AA652173 
                 KPNA1 
                 karyopherin alpha 
                 0.0380 
                 0.6914 
                 −1.3 
               
               
                   
                   
                   
                 1 (importin alpha 
                   
                   
                   
               
               
                   
                   
                   
                 5) 
                   
                   
                   
               
               
                 201853_s_at 
                 NM_021873 
                 CDC25B 
                 cell division cycle 
                 0.0043 
                 0.1229 
                 −1.3 
               
               
                   
                   
                   
                 25 homolog B ( S. cerevisiae ) 
                   
                   
                   
               
               
                 206200_s_at 
                 NM_001157 
                 ANXA11 
                 annexin A11 
                 0.0055 
                 0.2452 
                 −1.3 
               
               
                 209427_at 
                 AF064238 
                 SMTN 
                 smoothelin 
                 0.0020 
                 0.0645 
                 −1.3 
               
               
                 216591_s_at 
                 AF080579 
                 SDHC /// 
                 succinate 
                 0.0270 
                 0.4786 
                 −1.3 
               
               
                   
                   
                 LOC642502 
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 C, integral 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein, 
                   
                   
                   
               
               
                   
                   
                   
                 15 kDa /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 succinate 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit C 
                   
                   
                   
               
               
                   
                   
                   
                 isoform 3 precursor 
                   
                   
                   
               
               
                 208827_at 
                 BC000835 
                 PSMB6 
                 proteasome 
                 0.0049 
                 0.3860 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, beta type, 6 
                   
                   
                   
               
               
                 201387_s_at 
                 NM_004181 
                 UCHL1 
                 ubiquitin carboxyl- 
                 0.0307 
                 0.1309 
                 −1.3 
               
               
                   
                   
                   
                 terminal esterase 
                   
                   
                   
               
               
                   
                   
                   
                 L1 (ubiquitin 
                   
                   
                   
               
               
                   
                   
                   
                 thiolesterase) 
                   
                   
                   
               
               
                 203536_s_at 
                 NM_004804 
                 CIAO1 
                 cytosolic iron- 
                 0.0491 
                 0.4019 
                 −1.3 
               
               
                   
                   
                   
                 sulfur protein 
                   
                   
                   
               
               
                   
                   
                   
                 assembly 1 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 218580_x_at 
                 NM_017900 
                 AURKAIP1 
                 aurora kinase A 
                 0.0027 
                 0.4766 
                 −1.3 
               
               
                   
                   
                 /// 
                 interacting protein 
                   
                   
                   
               
               
                   
                   
                 LOC727877 
                 1 /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 Cyclin-L2 (Paneth 
                   
                   
                   
               
               
                   
                   
                   
                 cell-enhanced 
                   
                   
                   
               
               
                   
                   
                   
                 expression protein) 
                   
                   
                   
               
               
                 212178_s_at 
                 AK022555 
                 POM121 
                 POM121 
                 0.0119 
                 0.0807 
                 −1.3 
               
               
                   
                   
                 /// 
                 membrane 
                   
                   
                   
               
               
                   
                   
                 LOC340318 
                 glycoprotein (rat) 
                   
                   
                   
               
               
                   
                   
                 /// 
                 /// nuclear envelope 
                   
                   
                   
               
               
                   
                   
                 LOC729316 
                 pore membrane 
                   
                   
                   
               
               
                   
                   
                   
                 LOC340318 /// 
                   
                   
                   
               
               
                   
                   
                   
                 similar to Nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 envelope pore 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                   
                   
                   
                 POM 121 (Pore 
                   
                   
                   
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                   
                   
                   
                 of 121 kDa) (P145) 
                   
                   
                   
               
               
                 212285_s_at 
                 AW008051 
                 AGRIN 
                 agrin 
                 0.0401 
                 0.4488 
                 −1.3 
               
               
                 218902_at 
                 NM_017617 
                 NOTCH1 
                 Notch homolog 1, 
                 0.0314 
                 0.1325 
                 −1.3 
               
               
                   
                   
                   
                 translocation- 
                   
                   
                   
               
               
                   
                   
                   
                 associated 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 220547_s_at 
                 NM_019054 
                 FAM35A 
                 family with 
                 0.0297 
                 0.1633 
                 −1.3 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 35, member A 
                   
                   
                   
               
               
                 216602_s_at 
                 AD000092 
                 FARSLA 
                 phenylalanine- 
                 0.0210 
                 0.1596 
                 −1.3 
               
               
                   
                   
                   
                 tRNA synthetase- 
                   
                   
                   
               
               
                   
                   
                   
                 like, alpha subunit 
                   
                   
                   
               
               
                 213358_at 
                 AB018345 
                 KIAA0802 
                 KIAA0802 /// 
                 0.0039 
                 0.2086 
                 −1.3 
               
               
                   
                   
                 /// 
                 chromosome 21 
                   
                   
                   
               
               
                   
                   
                 C21orf57 
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 57 
                   
                   
                   
               
               
                 202370_s_at 
                 NM_001755 
                 CBFB 
                 core-binding 
                 0.0351 
                 0.2187 
                 −1.3 
               
               
                   
                   
                   
                 factor, beta subunit 
                   
                   
                   
               
               
                 200656_s_at 
                 NM_000918 
                 P4HB 
                 procollagen- 
                 0.0037 
                 0.0558 
                 −1.3 
               
               
                   
                   
                   
                 proline, 2- 
                   
                   
                   
               
               
                   
                   
                   
                 oxoglutarate 4- 
                   
                   
                   
               
               
                   
                   
                   
                 dioxygenase 
                   
                   
                   
               
               
                   
                   
                   
                 (proline 4- 
                   
                   
                   
               
               
                   
                   
                   
                 hydroxylase), beta 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 
                   
                   
                   
               
               
                 212512_s_at 
                 AA551784 
                 CARM1 
                 coactivator- 
                 0.0246 
                 0.2430 
                 −1.3 
               
               
                   
                   
                   
                 associated arginine 
                   
                   
                   
               
               
                   
                   
                   
                 methyltransferase 1 
                   
                   
                   
               
               
                 212796_s_at 
                 BF195608 
                 TBC1D2B 
                 TBC1 domain 
                 0.0233 
                 0.4904 
                 −1.3 
               
               
                   
                   
                   
                 family, member 2B 
                   
                   
                   
               
               
                 221434_s_at 
                 NM_031210 
                 C14orf156 
                 chromosome 14 
                 0.0342 
                 0.4605 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 156 /// 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 14 
                   
                   
                   
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 156 
                   
                   
                   
               
               
                 220358_at 
                 NM_018664 
                 SNFT 
                 Jun dimerization 
                 0.0209 
                 0.4938 
                 −1.3 
               
               
                   
                   
                   
                 protein p21SNFT 
                   
                   
                   
               
               
                 203040_s_at 
                 NM_000190 
                 HMBS 
                 hydroxymethylbilane 
                 0.0077 
                 0.4143 
                 −1.3 
               
               
                   
                   
                   
                 synthase 
                   
                   
                   
               
               
                 221764_at 
                 AL574186 
                 C19orf22 
                 chromosome 19 
                 0.0051 
                 0.0735 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 22 
                   
                   
                   
               
               
                 201155_s_at 
                 NM_014874 
                 MFN2 
                 mitofusin 2 
                 0.0078 
                 0.5620 
                 −1.3 
               
               
                 218492_s_at 
                 NM_030573 
                 THAP7 
                 THAP domain 
                 0.0114 
                 0.2235 
                 −1.3 
               
               
                   
                   
                   
                 containing 7 
                   
                   
                   
               
               
                 208968_s_at 
                 BC002568 
                 CIAPIN1 
                 cytokine induced 
                 0.0060 
                 0.3329 
                 −1.3 
               
               
                   
                   
                   
                 apoptosis inhibitor 1 
                   
                   
                   
               
               
                 211752_s_at 
                 BC005954 
                 NDUFS7 
                 NAPH 
                 0.0491 
                 0.3169 
                 −1.3 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) Fe—S 
                   
                   
                   
               
               
                   
                   
                   
                 protein 7, 20 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (NADH-coenzyme 
                   
                   
                   
               
               
                   
                   
                   
                 Q reductase) /// 
                   
                   
                   
               
               
                   
                   
                   
                 NAPH 
                   
                   
                   
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (ubiquinone) Fe—S 
                   
                   
                   
               
               
                   
                   
                   
                 protein 7, 20 kDa 
                   
                   
                   
               
               
                   
                   
                   
                 (NADH-coenzyme 
                   
                   
                   
               
               
                   
                   
                   
                 Q reductase) 
                   
                   
                   
               
               
                 203423_at 
                 NM_002899 
                 RBP1 
                 retinol binding 
                 0.0483 
                 0.5702 
                 −1.3 
               
               
                   
                   
                   
                 protein 1, cellular 
                   
                   
                   
               
               
                 219084_at 
                 NM_022455 
                 NSD1 
                 nuclear receptor 
                 0.0310 
                 0.2817 
                 −1.3 
               
               
                   
                   
                   
                 binding SET 
                   
                   
                   
               
               
                   
                   
                   
                 domain protein 1 
                   
                   
                   
               
               
                 215159_s_at 
                 AI239732 
                 NADK 
                 NAD kinase 
                 0.0266 
                 0.3031 
                 −1.3 
               
               
                 209413_at 
                 BC002431 
                 B4GALT2 
                 UDP- 
                 0.0309 
                 0.5550 
                 −1.3 
               
               
                   
                   
                   
                 Gal:betaGlcNAc 
                   
                   
                   
               
               
                   
                   
                   
                 beta 1,4- 
                   
                   
                   
               
               
                   
                   
                   
                 galactosyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 2 
                   
                   
                   
               
               
                 205293_x_at 
                 AB017120 
                 BAIAP2 
                 BAI1-associated 
                 0.0123 
                 0.2614 
                 −1.3 
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 202484_s_at 
                 AF072242 
                 MBD2 
                 methyl-CpG 
                 0.0457 
                 0.3651 
                 −1.3 
               
               
                   
                   
                   
                 binding domain 
                   
                   
                   
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 214170_x_at 
                 AA669797 
                 FH 
                 fumarate hydratase 
                 0.0248 
                 0.3513 
                 −1.3 
               
               
                 222216_s_at 
                 AK026857 
                 MRPL17 
                 mitochondrial 
                 0.0011 
                 0.0990 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L17 
                   
                   
                   
               
               
                 209461_x_at 
                 BC001648 
                 WDR18 
                 WD repeat domain 
                 0.0196 
                 0.1327 
                 −1.3 
               
               
                   
                   
                   
                 18 
                   
                   
                   
               
               
                 214141_x_at 
                 BF033354 
                 SFRS7 
                 splicing factor, 
                 0.0046 
                 0.0350 
                 −1.3 
               
               
                   
                   
                   
                 arginine/serine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 7, 35 kDa 
                   
                   
                   
               
               
                 202927_at 
                 NM_006221 
                 PIN1 
                 protein 
                 0.0059 
                 0.2652 
                 −1.3 
               
               
                   
                   
                   
                 (peptidylprolyl 
                   
                   
                   
               
               
                   
                   
                   
                 cis/trans 
                   
                   
                   
               
               
                   
                   
                   
                 isomerase) NIMA- 
                   
                   
                   
               
               
                   
                   
                   
                 interacting 1 
                   
                   
                   
               
               
                 201400_at 
                 NM_002795 
                 PSMB3 
                 proteasome 
                 0.0045 
                 0.1367 
                 −1.3 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, beta type, 3 
                   
                   
                   
               
               
                 202691_at 
                 NM_006938 
                 SNRPD1 
                 small nuclear 
                 0.0014 
                 0.0839 
                 −1.3 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 D1 polypeptide 
                   
                   
                   
               
               
                   
                   
                   
                 16 kDa 
                   
                   
                   
               
               
                 205449_at 
                 NM_013299 
                 SAC3D1 
                 SAC3 domain 
                 0.0253 
                 0.3329 
                 −1.3 
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 208679_s_at 
                 AF279893 
                 ARPC2 
                 actin related 
                 0.0015 
                 0.0811 
                 −1.3 
               
               
                   
                   
                   
                 protein 2/3 
                   
                   
                   
               
               
                   
                   
                   
                 complex, subunit 2, 
                   
                   
                   
               
               
                   
                   
                   
                 34 kDa 
                   
                   
                   
               
               
                 36936_at 
                 U58766 
                 TSTA3 
                 tissue specific 
                 0.0081 
                 0.6356 
                 −1.3 
               
               
                   
                   
                   
                 transplantation 
                   
                   
                   
               
               
                   
                   
                   
                 antigen P35B 
                   
                   
                   
               
               
                 209860_s_at 
                 J04543 
                 ANXA7 
                 annexin A7 
                 0.0133 
                 0.1925 
                 −1.3 
               
               
                 200730_s_at 
                 BF576710 
                 PTP4A1 
                 protein tyrosine 
                 0.0038 
                 0.0899 
                 −1.3 
               
               
                   
                   
                   
                 phosphatase type 
                   
                   
                   
               
               
                   
                   
                   
                 IVA, member 1 
                   
                   
                   
               
               
                 217118_s_at 
                 AK025608 
                 C22orf9 
                 chromosome 22 
                 0.0147 
                 0.2509 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 9 
                   
                   
                   
               
               
                 211926_s_at 
                 AI827941 
                 MYH9 
                 myosin, heavy 
                 0.0177 
                 0.1399 
                 −1.3 
               
               
                   
                   
                   
                 chain 9, non- 
                   
                   
                   
               
               
                   
                   
                   
                 muscle 
                   
                   
                   
               
               
                 202578_s_at 
                 NM_018332 
                 DDX19A 
                 DEAD (Asp-Glu- 
                 0.0307 
                 0.5964 
                 −1.3 
               
               
                   
                   
                   
                 Ala-As) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 19A 
                   
                   
                   
               
               
                 33307_at 
                 AL022316 
                 CTA- 
                 CGI-96 protein 
                 0.0138 
                 0.4373 
                 −1.3 
               
               
                   
                   
                 126B4.3 
                   
                   
                   
                   
               
               
                 204612_at 
                 NM_006823 
                 PKIA 
                 protein kinase 
                 0.0429 
                 0.6572 
                 −1.3 
               
               
                   
                   
                   
                 (cAMP-dependent, 
                   
                   
                   
               
               
                   
                   
                   
                 catalytic) inhibitor 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 
                   
                   
                   
               
               
                 208541_x_at 
                 NM_012251 
                 TFAM 
                 transcription factor 
                 0.0101 
                 0.1028 
                 −1.3 
               
               
                   
                   
                   
                 A, mitochondrial 
                   
                   
                   
               
               
                 209219_at 
                 L03411 
                 RDBP 
                 RD RNA binding 
                 0.0081 
                 0.4823 
                 −1.3 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 200687_s_at 
                 NM_012426 
                 SF3B3 
                 splicing factor 3b, 
                 0.0053 
                 0.1142 
                 −1.3 
               
               
                   
                   
                   
                 subunit 3, 130 kDa 
                   
                   
                   
               
               
                 209080_x_at 
                 AF118652 
                 TXNL2 
                 thioredoxin-like 2 
                 0.0060 
                 0.3555 
                 −1.3 
               
               
                 202415_s_at 
                 NM_012267 
                 HSPBP1 
                 hsp70-interacting 
                 0.0110 
                 0.1066 
                 −1.3 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                 210527_x_at 
                 L11645 
                 TUBA2 
                 tubulin, alpha 2 
                 0.0299 
                 0.5806 
                 −1.3 
               
               
                 213944_x_at 
                 BG236220 
                 NCLN 
                 Nicalin homolog 
                 0.0265 
                 0.9908 
                 −1.3 
               
               
                   
                   
                   
                 (zebrafish) 
                   
                   
                   
               
               
                 216080_s_at 
                 AC004770 
                 FADS3 
                 fatty acid 
                 0.0429 
                 0.6339 
                 −1.3 
               
               
                   
                   
                   
                 desaturase 3 
                   
                   
                   
               
               
                 214679_x_at 
                 AL110227 
                 GNA11 
                 guanine nucleotide 
                 0.0066 
                 0.0675 
                 −1.3 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein), alpha 11 
                   
                   
                   
               
               
                   
                   
                   
                 (Gq class) 
                   
                   
                   
               
               
                 218632_at 
                 NM_024602 
                 HECTD3 
                 HECT domain 
                 0.0079 
                 0.0819 
                 −1.3 
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 203410_at 
                 NM_006803 
                 AP3M2 
                 adaptor-related 
                 0.0084 
                 0.6490 
                 −1.3 
               
               
                   
                   
                   
                 protein complex 3, 
                   
                   
                   
               
               
                   
                   
                   
                 mu 2 subunit 
                   
                   
                   
               
               
                 212714_at 
                 AL050205 
                 LARP4 
                 La 
                 0.0259 
                 0.5696 
                 −1.3 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 domain family, 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 
                   
                   
                   
               
               
                 203733_at 
                 NM_014015 
                 DEXI 
                 dexamethasone- 
                 0.0096 
                 0.0775 
                 −1.3 
               
               
                   
                   
                   
                 induced transcript 
                   
                   
                   
               
               
                 204599_s_at 
                 NM_006428 
                 MRPL28 
                 mitochondrial 
                 0.0235 
                 0.7391 
                 −1.3 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 L28 
                   
                   
                   
               
               
                 213793_s_at 
                 BE550452 
                 HOMER1 
                 homer homolog 1 
                 0.0186 
                 0.0395 
                 −1.3 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 218331_s_at 
                 NM_017782 
                 C10orf18 
                 chromosome 10 
                 0.0356 
                 0.2221 
                 −1.3 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 18 
                   
                   
                   
               
               
                 204241_at 
                 BF055171 
                 ACOX3 
                 acyl-Coenzyme A 
                 0.0303 
                 0.3147 
                 −1.2 
               
               
                   
                   
                   
                 oxidase 3, 
                   
                   
                   
               
               
                   
                   
                   
                 pristanoyl 
                   
                   
                   
               
               
                 212165_at 
                 AF070537 
                 TMEM183A 
                 transmembrane 
                 0.0012 
                 0.2139 
                 −1.2 
               
               
                   
                   
                   
                 protein 183A 
                   
                   
                   
               
               
                 202296_s_at 
                 NM_007033 
                 RER1 
                 RER1 retention in 
                 0.0061 
                 0.7824 
                 −1.2 
               
               
                   
                   
                   
                 endoplasmic 
                   
                   
                   
               
               
                   
                   
                   
                 reticulum 1 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 201481_s_at 
                 NM_002862 
                 PYGB 
                 phosphorylase, 
                 0.0064 
                 0.1309 
                 −1.2 
               
               
                   
                   
                   
                 glycogen; brain 
                   
                   
                   
               
               
                 34868_at 
                 AB029012 
                 SMG5 
                 Smg-5 homolog, 
                 0.0054 
                 0.3627 
                 −1.2 
               
               
                   
                   
                   
                 nonsense mediated 
                   
                   
                   
               
               
                   
                   
                   
                 mRNA decay 
                   
                   
                   
               
               
                   
                   
                   
                 factor ( C. elegans ) 
                   
                   
                   
               
               
                 212564_at 
                 AA523921 
                 KCTD2 
                 potassium channel 
                 0.0215 
                 0.0579 
                 −1.2 
               
               
                   
                   
                   
                 tetramerisation 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 2 
                   
                   
                   
               
               
                 204117_at 
                 NM_002726 
                 PREP 
                 prolyl 
                 0.0277 
                 0.4656 
                 −1.2 
               
               
                   
                   
                   
                 endopeptidase 
                   
                   
                   
               
               
                 211052_s_at 
                 BC006364 
                 TBCD 
                 tubulin folding 
                 0.0091 
                 0.0783 
                 −1.2 
               
               
                   
                   
                   
                 cofactor D /// 
                   
                   
                   
               
               
                   
                   
                   
                 tubulin folding 
                   
                   
                   
               
               
                   
                   
                   
                 cofactor D 
                   
                   
                   
               
               
                 202440_s_at 
                 NM_005418 
                 ST5 
                 suppression of 
                 0.0080 
                 0.0861 
                 −1.2 
               
               
                   
                   
                   
                 tumorigenicity 5 
                   
                   
                   
               
               
                 202670_at 
                 AI571419 
                 MAP2K1 
                 mitogen-activated 
                 0.0255 
                 0.3612 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 1 
                   
                   
                   
               
               
                 203452_at 
                 NM_012200 
                 B3GAT3 
                 beta-1,3- 
                 0.0172 
                 0.0662 
                 −1.2 
               
               
                   
                   
                   
                 glucuronyltransferase 3 
                   
                   
                   
               
               
                   
                   
                   
                 (glucuronosyltranserase 
                   
                   
                   
               
               
                   
                   
                   
                 I) 
                   
                   
                   
               
               
                 200837_at 
                 NM_005745 
                 BCAP31 
                 B-cell receptor- 
                 0.0100 
                 0.4385 
                 −1.2 
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                   
                   
                   
                 31 
                   
                   
                   
               
               
                 219611_s_at 
                 NM_022778 
                 CCDC21 
                 coiled-coil domain 
                 0.0094 
                 0.0843 
                 −1.2 
               
               
                   
                   
                   
                 containing 21 
                   
                   
                   
               
               
                 213535_s_at 
                 AA910614 
                 UBE2I 
                 ubiquitin- 
                 0.0011 
                 0.1305 
                 −1.2 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2I 
                   
                   
                   
               
               
                   
                   
                   
                 (UBC9 homolog, 
                   
                   
                   
               
               
                   
                   
                   
                 yeast) 
                   
                   
                   
               
               
                 200852_x_at 
                 NM_005273 
                 GNB2 
                 guanine nucleotide 
                 0.0007 
                 0.0274 
                 −1.2 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein), beta 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 2 
                   
                   
                   
               
               
                 201578_at 
                 NM_005397 
                 PODXL 
                 podocalyxin-like 
                 0.0269 
                 0.7420 
                 −1.2 
               
               
                 212696_s_at 
                 BF968633 
                 RNF4 
                 ring finger protein 4 
                 0.0135 
                 0.5482 
                 −1.2 
               
               
                 210869_s_at 
                 M29277 
                 MCAM 
                 melanoma cell 
                 0.0197 
                 0.3612 
                 −1.2 
               
               
                   
                   
                   
                 adhesion molecule 
                   
                   
                   
               
               
                 217787_s_at 
                 AL525086 
                 GALNT2 
                 UDP-N-acetyl- 
                 0.0500 
                 0.1670 
                 −1.2 
               
               
                   
                   
                   
                 alpha-D- 
                   
                   
                   
               
               
                   
                   
                   
                 galactosamine:poly 
                   
                   
                   
               
               
                   
                   
                   
                 peptide N- 
                   
                   
                   
               
               
                   
                   
                   
                 acetylgalactosaminyltransferase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (GalNAc-T2) 
                   
                   
                   
               
               
                 200774_at 
                 BE963765 
                 FAM120A 
                 family with 
                 0.0219 
                 0.2718 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 120A 
                   
                   
                   
               
               
                 211037_s_at 
                 BC006309 
                 LENG4 
                 leukocyte receptor 
                 0.0266 
                 0.1880 
                 −1.2 
               
               
                   
                   
                   
                 cluster (LRC) 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 /// 
                   
                   
                   
               
               
                   
                   
                   
                 leukocyte receptor 
                   
                   
                   
               
               
                   
                   
                   
                 cluster (LRC) 
                   
                   
                   
               
               
                   
                   
                   
                 member 4 
                   
                   
                   
               
               
                 204976_s_at 
                 AK023637 
                 AMMECR1 
                 Alport syndrome, 
                 0.0193 
                 0.3064 
                 −1.2 
               
               
                   
                   
                   
                 mental retardation, 
                   
                   
                   
               
               
                   
                   
                   
                 midface hypoplasia 
                   
                   
                   
               
               
                   
                   
                   
                 and elliptocytosis 
                   
                   
                   
               
               
                   
                   
                   
                 chromosomal 
                   
                   
                   
               
               
                   
                   
                   
                 region, gene 1 
                   
                   
                   
               
               
                 212978_at 
                 AU146004 
                 LRRC8B 
                 Leucine rich repeat 
                 0.0233 
                 0.0532 
                 −1.2 
               
               
                   
                   
                   
                 containing 8 
                   
                   
                   
               
               
                   
                   
                   
                 family, member B 
                   
                   
                   
               
               
                 218058_at 
                 NM_014593 
                 CXXC1 
                 CXXC finger 1 
                 0.0304 
                 0.1699 
                 −1.2 
               
               
                   
                   
                   
                 (PHD domain) 
                   
                   
                   
               
               
                 212861_at 
                 BF690150 
                 MFSD5 
                 major facilitator 
                 0.0294 
                 0.2091 
                 −1.2 
               
               
                   
                   
                   
                 superfamily 
                   
                   
                   
               
               
                   
                   
                   
                 domain containing 5 
                   
                   
                   
               
               
                 218112_at 
                 NM_023936 
                 MRPS34 
                 mitochondrial 
                 0.0079 
                 0.5000 
                 −1.2 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S34 
                   
                   
                   
               
               
                 221828_s_at 
                 AK024432 
                 FAM125B 
                 family with 
                 0.0057 
                 0.1233 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 125, member B 
                   
                   
                   
               
               
                 201397_at 
                 NM_006623 
                 PHGDH 
                 phosphoglycerate 
                 0.0026 
                 0.0935 
                 −1.2 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                 202039_at 
                 NM_004740 
                 TIAF1 /// 
                 TGFB1-induced 
                 0.0138 
                 0.5359 
                 −1.2 
               
               
                   
                   
                 MYO18A 
                 anti-apoptotic 
                   
                   
                   
               
               
                   
                   
                   
                 factor 1 /// myosin 
                   
                   
                   
               
               
                   
                   
                   
                 XVIIIA 
                   
                   
                   
               
               
                 204518_s_at 
                 NM_000943 
                 PPIC 
                 peptidylprolyl 
                 0.0138 
                 0.6379 
                 −1.2 
               
               
                   
                   
                   
                 isomerase C 
                   
                   
                   
               
               
                   
                   
                   
                 (cyclophilin C) 
                   
                   
                   
               
               
                 211804_s_at 
                 AB012305 
                 CDK2 /// 
                 cyclin-dependent 
                 0.0372 
                 0.1019 
                 −1.2 
               
               
                   
                   
                 BCDO2 
                 kinase 2 /// beta- 
                   
                   
                   
               
               
                   
                   
                   
                 carotene 
                   
                   
                   
               
               
                   
                   
                   
                 dioxygenase 2 
                   
                   
                   
               
               
                 208767_s_at 
                 AW149681 
                 LAPTM4B 
                 lysosomal 
                 0.0287 
                 0.7180 
                 −1.2 
               
               
                   
                   
                   
                 associated protein 
                   
                   
                   
               
               
                   
                   
                   
                 transmembrane 4 
                   
                   
                   
               
               
                   
                   
                   
                 beta 
                   
                   
                   
               
               
                 201912_s_at 
                 NM_002094 
                 GSPT1 
                 G1 to S phase 
                 0.0415 
                 0.9318 
                 −1.2 
               
               
                   
                   
                   
                 transition 1 /// G1 
                   
                   
                   
               
               
                   
                   
                   
                 to S phase 
                   
                   
                   
               
               
                   
                   
                   
                 transition 1 
                   
                   
                   
               
               
                 201272_at 
                 NM_001628 
                 AKR1B1 
                 aldo-keto reductase 
                 0.0052 
                 0.0958 
                 −1.2 
               
               
                   
                   
                   
                 family 1, member 
                   
                   
                   
               
               
                   
                   
                   
                 B1 (aldose 
                   
                   
                   
               
               
                   
                   
                   
                 reductase) 
                   
                   
                   
               
               
                 201144_s_at 
                 NM_004094 
                 EIF2S1 
                 eukaryotic 
                 0.0018 
                 0.0260 
                 −1.2 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 2, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 1 alpha, 
                   
                   
                   
               
               
                   
                   
                   
                 35 kDa 
                   
                   
                   
               
               
                 208999_at 
                 D86957 
                 8-Sep 
                 septin 8 
                 0.0370 
                 0.3680 
                 −1.2 
               
               
                 202848_s_at 
                 BG423052 
                 GRK6 
                 G protein-coupled 
                 0.0124 
                 0.2148 
                 −1.2 
               
               
                   
                   
                   
                 receptor kinase 6 
                   
                   
                   
               
               
                 218653_at 
                 NM_014252 
                 SLC25A15 
                 solute carrier 
                 0.0290 
                 0.9035 
                 −1.2 
               
               
                   
                   
                   
                 family 25 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 carrier; ornithine 
                   
                   
                   
               
               
                   
                   
                   
                 transporter) 
                   
                   
                   
               
               
                   
                   
                   
                 member 15 
                   
                   
                   
               
               
                 202640_s_at 
                 NM_003624 
                 RANBP3 
                 RAN binding 
                 0.0202 
                 0.3932 
                 −1.2 
               
               
                   
                   
                   
                 protein 3 
                   
                   
                   
               
               
                 201559_s_at 
                 AF109196 
                 CLIC4 
                 chloride 
                 0.0481 
                 0.5454 
                 −1.2 
               
               
                   
                   
                   
                 intracellular 
                   
                   
                   
               
               
                   
                   
                   
                 channel 4 
                   
                   
                   
               
               
                 201414_s_at 
                 NM_005969 
                 NAP1L4 
                 nucleosome 
                 0.0127 
                 0.0843 
                 −1.2 
               
               
                   
                   
                   
                 assembly protein 1- 
                   
                   
                   
               
               
                   
                   
                   
                 like 4 
                   
                   
                   
               
               
                 200790_at 
                 NM_002539 
                 ODC1 
                 ornithine 
                 0.0076 
                 0.7147 
                 −1.2 
               
               
                   
                   
                   
                 decarboxylase 1 
                   
                   
                   
               
               
                 219076_s_at 
                 NM_018663 
                 PXMP2 
                 peroxisomal 
                 0.0101 
                 0.0783 
                 −1.2 
               
               
                   
                   
                   
                 membrane protein 
                   
                   
                   
               
               
                   
                   
                   
                 2, 22 kDa 
                   
                   
                   
               
               
                 204123_at 
                 NM_013975 
                 LIG3 
                 ligase III, DNA, 
                 0.0209 
                 0.5066 
                 −1.2 
               
               
                   
                   
                   
                 ATP-dependent 
                   
                   
                   
               
               
                 209208_at 
                 AF059752 
                 MPDU1 
                 mannose-P- 
                 0.0105 
                 0.1514 
                 −1.2 
               
               
                   
                   
                   
                 dolichol utilization 
                   
                   
                   
               
               
                   
                   
                   
                 defect 1 
                   
                   
                   
               
               
                 202348_s_at 
                 BC000674 
                 TOR1A 
                 torsin family 1, 
                 0.0155 
                 0.9365 
                 −1.2 
               
               
                   
                   
                   
                 member A (torsin 
                   
                   
                   
               
               
                   
                   
                   
                 A) 
                   
                   
                   
               
               
                 212115_at 
                 AK023154 
                 HN1L 
                 hematological and 
                 0.0039 
                 0.8034 
                 −1.2 
               
               
                   
                   
                   
                 neurological 
                   
                   
                   
               
               
                   
                   
                   
                 expressed 1-like 
                   
                   
                   
               
               
                 201851_at 
                 NM_003025 
                 SH3GL1 
                 SH3-domain 
                 0.0389 
                 0.8279 
                 −1.2 
               
               
                   
                   
                   
                 GRB2-like 1 
                   
                   
                   
               
               
                 211714_x_at 
                 BC005838 
                 TUBB 
                 tubulin, beta /// 
                 0.0210 
                 0.4381 
                 −1.2 
               
               
                   
                   
                   
                 tubulin, beta 
                   
                   
                   
               
               
                 209094_at 
                 AL078459 
                 DDAH1 
                 dimethylarginine 
                 0.0015 
                 0.0447 
                 −1.2 
               
               
                   
                   
                   
                 dimethylaminohydrolase 1 
                   
                   
                   
               
               
                 201715_s_at 
                 NM_014977 
                 ACIN1 
                 apoptotic 
                 0.0426 
                 0.1405 
                 −1.2 
               
               
                   
                   
                   
                 chromatin 
                   
                   
                   
               
               
                   
                   
                   
                 condensation 
                   
                   
                   
               
               
                   
                   
                   
                 inducer 1 
                   
                   
                   
               
               
                 218774_at 
                 NM_014026 
                 DCPS 
                 decapping enzyme, 
                 0.0055 
                 0.0571 
                 −1.2 
               
               
                   
                   
                   
                 scavenger 
                   
                   
                   
               
               
                 218629_at 
                 NM_005631 
                 SMO 
                 smoothened 
                 0.0234 
                 0.1969 
                 −1.2 
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 218016_s_at 
                 NM_018119 
                 POLR3E 
                 polymerase (RNA) 
                 0.0244 
                 0.4851 
                 −1.2 
               
               
                   
                   
                   
                 III (DNA directed) 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide E 
                   
                   
                   
               
               
                   
                   
                   
                 (80 kD) 
                   
                   
                   
               
               
                 218741_at 
                 NM_024053 
                 CENPM 
                 centromere protein M 
                 0.0144 
                 0.4422 
                 −1.2 
               
               
                 218586_at 
                 NM_018270 
                 C20orf20 
                 chromosome 20 
                 0.0036 
                 0.3145 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 20 
                   
                   
                   
               
               
                 219260_s_at 
                 NM_015362 
                 C17orf81 
                 chromosome 17 
                 0.0105 
                 0.2294 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 81 
                   
                   
                   
               
               
                 220094_s_at 
                 NM_022102 
                 CCDC90A 
                 coiled-coil domain 
                 0.0461 
                 0.2205 
                 −1.2 
               
               
                   
                   
                   
                 containing 90A 
                   
                   
                   
               
               
                 208831_x_at 
                 D79984 
                 SUPT6H 
                 suppressor of Ty 6 
                 0.0222 
                 0.1216 
                 −1.2 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 214828_s_at 
                 AL157851 
                 dJ222E13.2 
                 similar to CGI-96 
                 0.0105 
                 0.1409 
                 −1.2 
               
               
                 209014_at 
                 AF217963 
                 MAGED1 
                 melanoma antigen 
                 0.0008 
                 0.0299 
                 −1.2 
               
               
                   
                   
                   
                 family D, 1 
                   
                   
                   
               
               
                 212766_s_at 
                 AW294587 
                 ISG20L2 
                 interferon 
                 0.0111 
                 0.8419 
                 −1.2 
               
               
                   
                   
                   
                 stimulated 
                   
                   
                   
               
               
                   
                   
                   
                 exonuclease gene 
                   
                   
                   
               
               
                   
                   
                   
                 20 kDa-like 2 
                   
                   
                   
               
               
                 204266_s_at 
                 NM_001277 
                 CHKA /// 
                 choline kinase 
                 0.0249 
                 0.3418 
                 −1.2 
               
               
                   
                   
                 LOC650122 
                 alpha /// similar to 
                   
                   
                   
               
               
                   
                   
                   
                 choline kinase 
                   
                   
                   
               
               
                   
                   
                   
                 alpha isoform a 
                   
                   
                   
               
               
                 214869_x_at 
                 AK021533 
                 GAPVD1 
                 GTPase activating 
                 0.0205 
                 0.7717 
                 −1.2 
               
               
                   
                   
                   
                 protein and VPS9 
                   
                   
                   
               
               
                   
                   
                   
                 domains 1 
                   
                   
                   
               
               
                 221877_at 
                 BF508835 
                 — 
                 CDNA FLJ38849 
                 0.0086 
                 0.5431 
                 −1.2 
               
               
                   
                   
                   
                 fis, clone 
                   
                   
                   
               
               
                   
                   
                   
                 MESAN2008936 
                   
                   
                   
               
               
                 200697_at 
                 NM_000188 
                 HK1 
                 hexokinase 1 
                 0.0416 
                 0.6041 
                 −1.2 
               
               
                 211750_x_at 
                 BC005946 
                 TUBA6 
                 tubulin, alpha 6 /// 
                 0.0011 
                 0.0549 
                 −1.2 
               
               
                   
                   
                   
                 tubulin, alpha 6 
                   
                   
                   
               
               
                 201587_s_at 
                 NM_001569 
                 IRAK1 
                 interleukin-1 
                 0.0035 
                 0.2935 
                 −1.2 
               
               
                   
                   
                   
                 receptor-associated 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 1 
                   
                   
                   
               
               
                 209663_s_at 
                 AF072132 
                 ITGA7 
                 integrin, alpha 7 
                 0.0417 
                 0.0631 
                 −1.2 
               
               
                 221247_s_at 
                 NM_030798 
                 WBSCR16 
                 Williams-Beuren 
                 0.0295 
                 0.1278 
                 −1.2 
               
               
                   
                   
                   
                 syndrome 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 
                   
                   
                   
               
               
                   
                   
                   
                 region 16 /// 
                   
                   
                   
               
               
                   
                   
                   
                 Williams-Beuren 
                   
                   
                   
               
               
                   
                   
                   
                 syndrome 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 
                   
                   
                   
               
               
                   
                   
                   
                 region 16 
                   
                   
                   
               
               
                 201271_s_at 
                 NM_016732 
                 RALY 
                 RNA binding 
                 0.0275 
                 0.2379 
                 −1.2 
               
               
                   
                   
                   
                 protein, 
                   
                   
                   
               
               
                   
                   
                   
                 autoantigenic 
                   
                   
                   
               
               
                   
                   
                   
                 (hnRNP-associated 
                   
                   
                   
               
               
                   
                   
                   
                 with lethal yellow 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (mouse)) 
                   
                   
                   
               
               
                 217754_at 
                 NM_019082 
                 DDX56 
                 DEAD (Asp-Glu- 
                 0.0050 
                 0.1143 
                 −1.2 
               
               
                   
                   
                   
                 Ala-Asp) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 56 
                   
                   
                   
               
               
                 217838_s_at 
                 NM_016337 
                 EVL 
                 Enah/Vasp-like 
                 0.0362 
                 0.0971 
                 −1.2 
               
               
                 200762_at 
                 NM_001386 
                 DPYSL2 
                 dihydropyrimidinase- 
                 0.0078 
                 0.2899 
                 −1.2 
               
               
                   
                   
                   
                 like 2 
                   
                   
                   
               
               
                 218156_s_at 
                 NM_018128 
                 TSR1 
                 TSR1, 20S rRNA 
                 0.0411 
                 0.6879 
                 −1.2 
               
               
                   
                   
                   
                 accumulation, 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 219420_s_at 
                 NM_023077 
                 C1orf163 
                 chromosome 1 
                 0.0357 
                 0.0712 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 163 
                   
                   
                   
               
               
                 202945_at 
                 NM_004957 
                 FPGS 
                 folylpolyglutamate 
                 0.0044 
                 0.0987 
                 −1.2 
               
               
                   
                   
                   
                 synthase 
                   
                   
                   
               
               
                 203795_s_at 
                 NM_020993 
                 BCL7A 
                 B-cell 
                 0.0366 
                 0.0812 
                 −1.2 
               
               
                   
                   
                   
                 CLL/lymphoma 
                   
                   
                   
               
               
                   
                   
                   
                 7A 
                   
                   
                   
               
               
                 203550_s_at 
                 NM_006589 
                 C1orf2 
                 chromosome 1 
                 0.0123 
                 0.4067 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 2 
                   
                   
                   
               
               
                 220244_at 
                 NM_013343 
                 LOH3CR2A 
                 loss of 
                 0.0430 
                 0.3328 
                 −1.2 
               
               
                   
                   
                   
                 heterozygosity, 3, 
                   
                   
                   
               
               
                   
                   
                   
                 chromosomal 
                   
                   
                   
               
               
                   
                   
                   
                 region 2, gene A 
                   
                   
                   
               
               
                 201135_at 
                 NM_004092 
                 ECHS1 
                 enoyl Coenzyme A 
                 0.0051 
                 0.1455 
                 −1.2 
               
               
                   
                   
                   
                 hydratase, short 
                   
                   
                   
               
               
                   
                   
                   
                 chain, 1, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 218099_at 
                 NM_018469 
                 TEX2 
                 testis expressed 
                 0.0413 
                 0.2203 
                 −1.2 
               
               
                   
                   
                   
                 sequence 2 
                   
                   
                   
               
               
                 214501_s_at 
                 AF044286 
                 TLR4 /// 
                 toll-like receptor 4 
                 0.0108 
                 0.4608 
                 −1.2 
               
               
                   
                   
                 H2AFY 
                 /// H2A histone 
                   
                   
                   
               
               
                   
                   
                   
                 family, member Y 
                   
                   
                   
               
               
                 217729_s_at 
                 NM_001130 
                 AES 
                 amino-terminal 
                 0.0049 
                 0.0782 
                 −1.2 
               
               
                   
                   
                   
                 enhancer of split 
                   
                   
                   
               
               
                 212871_at 
                 NM_003668 
                 MAPKAPK5 
                 mitogen-activated 
                 0.0160 
                 0.1840 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase- 
                   
                   
                   
               
               
                   
                   
                   
                 activated protein 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 5 
                   
                   
                   
               
               
                 219496_at 
                 NM_023016 
                 ANKRD57 
                 ankyrin repeat 
                 0.0463 
                 0.1807 
                 −1.2 
               
               
                   
                   
                   
                 domain 57 
                   
                   
                   
               
               
                 219330_at 
                 NM_024062 
                 VANGL1 
                 vang-like 1 (van 
                 0.0128 
                 0.1514 
                 −1.2 
               
               
                   
                   
                   
                 gogh,  Drosophila)   
                   
                   
                   
               
               
                 219806_s_at 
                 NM_020179 
                 C11orf75 
                 chromosome 11 
                 0.0311 
                 0.2261 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 75 
                   
                   
                   
               
               
                 201460_at 
                 AI141802 
                 MAPKAPK2 
                 mitogen-activated 
                 0.0147 
                 0.5934 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase- 
                   
                   
                   
               
               
                   
                   
                   
                 activated protein 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 2 
                   
                   
                   
               
               
                 201763_s_at 
                 NM_001350 
                 DAXX 
                 death-associated 
                 0.0012 
                 0.0157 
                 −1.2 
               
               
                   
                   
                   
                 protein 6 
                   
                   
                   
               
               
                 211432_s_at 
                 U05682 
                 TYRO3 
                 TYRO3 protein 
                 0.0329 
                 0.2586 
                 −1.2 
               
               
                   
                   
                   
                 tyrosine kinase 
                   
                   
                   
               
               
                 204493_at 
                 NM_001196 
                 BID 
                 BH3 interacting 
                 0.0129 
                 0.1146 
                 −1.2 
               
               
                   
                   
                   
                 domain death 
                   
                   
                   
               
               
                   
                   
                   
                 agonist 
                   
                   
                   
               
               
                 221267_s_at 
                 NM_031213 
                 FAM108A1 
                 family with 
                 0.0178 
                 0.3019 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 108, member A1 /// 
                   
                   
                   
               
               
                   
                   
                   
                 family with 
                   
                   
                   
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 108, member A1 
                   
                   
                   
               
               
                 212333_at 
                 AL049943 
                 FAM98A 
                 family with 
                 0.0206 
                 0.0310 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 98, member A 
                   
                   
                   
               
               
                 206633_at 
                 NM_000079 
                 CHRNA1 
                 cholinergic 
                 0.0127 
                 0.2332 
                 −1.2 
               
               
                   
                   
                   
                 receptor, nicotinic, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha 1 (muscle) 
                   
                   
                   
               
               
                 201841_s_at 
                 NM_001540 
                 HSPB1 /// 
                 heat shock 27 kDa 
                 0.0034 
                 0.2235 
                 −1.2 
               
               
                   
                   
                 MEIS3 
                 protein 1 /// Meis1, 
                   
                   
                   
               
               
                   
                   
                   
                 myeloid ecotropic 
                   
                   
                   
               
               
                   
                   
                   
                 viral integration 
                   
                   
                   
               
               
                   
                   
                   
                 site 1 homolog 3 
                   
                   
                   
               
               
                   
                   
                   
                 (mouse) 
                   
                   
                   
               
               
                 204044_at 
                 NM_014298 
                 QPRT 
                 quinolinate 
                 0.0416 
                 0.8129 
                 −1.2 
               
               
                   
                   
                   
                 phosphoribosyltransferase 
                   
                   
                   
               
               
                   
                   
                   
                 (nicotinate- 
                   
                   
                   
               
               
                   
                   
                   
                 nucleotide 
                   
                   
                   
               
               
                   
                   
                   
                 pyrophosphorylase 
                   
                   
                   
               
               
                   
                   
                   
                 (carboxylating)) 
                   
                   
                   
               
               
                 210011_s_at 
                 BC000527 
                 EWSR1 
                 Ewing sarcoma 
                 0.0070 
                 0.0721 
                 −1.2 
               
               
                   
                   
                   
                 breakpoint region 1 
                   
                   
                   
               
               
                 218898_at 
                 NM_024792 
                 FAM57A 
                 family with 
                 0.0471 
                 0.7205 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 57, member A 
                   
                   
                   
               
               
                 202518_at 
                 NM_001707 
                 BCL7B 
                 B-cell 
                 0.0264 
                 0.2789 
                 −1.2 
               
               
                   
                   
                   
                 CLL/lymphoma 7B 
                   
                   
                   
               
               
                 202069_s_at 
                 AI826060 
                 IDH3A 
                 isocitrate 
                 0.0224 
                 0.4380 
                 −1.2 
               
               
                   
                   
                   
                 dehydrogenase 3 
                   
                   
                   
               
               
                   
                   
                   
                 (NAD+) alpha 
                   
                   
                   
               
               
                 220258_s_at 
                 NM_018081 
                 WDR79 
                 WD repeat domain 
                 0.0225 
                 0.2213 
                 −1.2 
               
               
                   
                   
                   
                 79 
                   
                   
                   
               
               
                 201194_at 
                 NM_003009 
                 SEPW1 
                 selenoprotein W, 1 
                 0.0162 
                 0.1636 
                 −1.2 
               
               
                 201792_at 
                 NM_001129 
                 AEBP1 
                 AE binding protein 1 
                 0.0193 
                 0.1129 
                 −1.2 
               
               
                 204126_s_at 
                 NM_003504 
                 CDC45L 
                 CDC45 cell 
                 0.0253 
                 0.5416 
                 −1.2 
               
               
                   
                   
                   
                 division cycle 45- 
                   
                   
                   
               
               
                   
                   
                   
                 like ( S. cerevisiae ) 
                   
                   
                   
               
               
                 218961_s_at 
                 NM_007254 
                 PNKP 
                 polynucleotide 
                 0.0225 
                 0.1313 
                 −1.2 
               
               
                   
                   
                   
                 kinase 3′- 
                   
                   
                   
               
               
                   
                   
                   
                 phosphatase 
                   
                   
                   
               
               
                 209044_x_at 
                 BC004273 
                 SF3B4 
                 splicing factor 3b, 
                 0.0014 
                 0.3838 
                 −1.2 
               
               
                   
                   
                   
                 subunit 4, 49 kDa 
                   
                   
                   
               
               
                 210415_s_at 
                 AF053970 
                 ODF2 
                 outer dense fiber of 
                 0.0260 
                 0.5497 
                 −1.2 
               
               
                   
                   
                   
                 sperm tails 2 
                   
                   
                   
               
               
                 203210_s_at 
                 NM_007370 
                 RFC5 
                 replication factor C 
                 0.0375 
                 0.1357 
                 −1.2 
               
               
                   
                   
                   
                 (activator 1) 5, 
                   
                   
                   
               
               
                   
                   
                   
                 36.5 kDa 
                   
                   
                   
               
               
                 212271_at 
                 AA195999 
                 MAPK1 
                 mitogen-activated 
                 0.0470 
                 0.6623 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase 1 
                   
                   
                   
               
               
                 208696_at 
                 AF275798 
                 CCT5 
                 chaperonin 
                 0.0242 
                 0.9588 
                 −1.2 
               
               
                   
                   
                   
                 containing TCP1, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 5 (epsilon) 
                   
                   
                   
               
               
                 218365_s_at 
                 AI765051 
                 DARS2 
                 aspartyl-tRNA 
                 0.0157 
                 0.2829 
                 −1.2 
               
               
                   
                   
                   
                 synthetase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial) 
                   
                   
                   
               
               
                 218848_at 
                 NM_024339 
                 THOC6 
                 THO complex 6 
                 0.0396 
                 0.4185 
                 −1.2 
               
               
                   
                   
                   
                 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 218542_at 
                 NM_018131 
                 CEP55 
                 centrosomal 
                 0.0061 
                 0.5899 
                 −1.2 
               
               
                   
                   
                   
                 protein 55 kDa 
                   
                   
                   
               
               
                 206845_s_at 
                 NM_014771 
                 RNF40 
                 ring finger protein 
                 0.0244 
                 0.1693 
                 −1.2 
               
               
                   
                   
                   
                 40 
                   
                   
                   
               
               
                 202592_at 
                 NM_001487 
                 BLOC1S1 
                 biogenesis of 
                 0.0112 
                 0.6525 
                 −1.2 
               
               
                   
                   
                   
                 lysosome-related 
                   
                   
                   
               
               
                   
                   
                   
                 organelles 
                   
                   
                   
               
               
                   
                   
                   
                 complex-1, subunit 1 
                   
                   
                   
               
               
                 218566_s_at 
                 NM_012124 
                 CHORDC1 
                 cysteine and 
                 0.0484 
                 0.3010 
                 −1.2 
               
               
                   
                   
                   
                 histidine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 domain (CHORD)- 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 200691_s_at 
                 BC000478 
                 HSPA9 
                 heat shock 70 kDa 
                 0.0155 
                 0.4830 
                 −1.2 
               
               
                   
                   
                   
                 protein 9 (mortalin) 
                   
                   
                   
               
               
                 218187_s_at 
                 NM_023080 
                 C8orf33 
                 chromosome 8 
                 0.0483 
                 0.5066 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 33 
                   
                   
                   
               
               
                 218120_s_at 
                 D21243 
                 HMOX2 
                 heme oxygenase 
                 0.0440 
                 0.6657 
                 −1.2 
               
               
                   
                   
                   
                 (decycling) 2 
                   
                   
                   
               
               
                 221737_at 
                 AK024696 
                 GNA12 
                 guanine nucleotide 
                 0.0258 
                 0.4334 
                 −1.2 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein) alpha 12 
                   
                   
                   
               
               
                 202828_s_at 
                 NM_004995 
                 MMP14 
                 matrix 
                 0.0202 
                 0.5070 
                 −1.2 
               
               
                   
                   
                   
                 metallopeptidase 
                   
                   
                   
               
               
                   
                   
                   
                 14 (membrane- 
                   
                   
                   
               
               
                   
                   
                   
                 inserted) 
                   
                   
                   
               
               
                 201357_s_at 
                 NM_005877 
                 SF3A1 
                 splicing factor 3a, 
                 0.0267 
                 0.0877 
                 −1.2 
               
               
                   
                   
                   
                 subunit 1, 120 kDa 
                   
                   
                   
               
               
                 213696_s_at 
                 AA421957 
                 MED8 
                 mediator of RNA 
                 0.0487 
                 0.2629 
                 −1.2 
               
               
                   
                   
                   
                 polymerase II 
                   
                   
                   
               
               
                   
                   
                   
                 transcription, 
                   
                   
                   
               
               
                   
                   
                   
                 subunit 8 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 204928_s_at 
                 NM_019848 
                 SLC10A3 
                 solute carrier 
                 0.0039 
                 0.2235 
                 −1.2 
               
               
                   
                   
                   
                 family 10 
                   
                   
                   
               
               
                   
                   
                   
                 (sodium/bile acid 
                   
                   
                   
               
               
                   
                   
                   
                 cotransporter 
                   
                   
                   
               
               
                   
                   
                   
                 family), member 3 
                   
                   
                   
               
               
                 217932_at 
                 NM_015971 
                 MRPS7 
                 mitochondrial 
                 0.0014 
                 0.1160 
                 −1.2 
               
               
                   
                   
                   
                 ribosomal protein 
                   
                   
                   
               
               
                   
                   
                   
                 S7 
                   
                   
                   
               
               
                 201263_at 
                 NM_003191 
                 TARS 
                 threonyl-tRNA 
                 0.0302 
                 0.0907 
                 −1.2 
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 207121_s_at 
                 NM_002748 
                 MAPK6 
                 mitogen-activated 
                 0.0064 
                 0.1007 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase 6 
                   
                   
                   
               
               
                 217221_x_at 
                 AL137421 
                 RBM10 
                 RNA binding motif 
                 0.0188 
                 0.0866 
                 −1.2 
               
               
                   
                   
                   
                 protein 10 
                   
                   
                   
               
               
                 202816_s_at 
                 AW292882 
                 SS18 
                 synovial sarcoma 
                 0.0084 
                 0.0541 
                 −1.2 
               
               
                   
                   
                   
                 translocation, 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 18 
                   
                   
                   
               
               
                 1861_at 
                 U66879 
                 BAD 
                 BCL2-antagonist 
                 0.0380 
                 0.5209 
                 −1.2 
               
               
                   
                   
                   
                 of cell death 
                   
                   
                   
               
               
                 202108_at 
                 NM_000285 
                 PEPD 
                 peptidase D 
                 0.0178 
                 0.2205 
                 −1.2 
               
               
                 204993_at 
                 NM_002073 
                 GNAZ 
                 guanine nucleotide 
                 0.0293 
                 0.4344 
                 −1.2 
               
               
                   
                   
                   
                 binding protein (G 
                   
                   
                   
               
               
                   
                   
                   
                 protein), alpha z 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 
                   
                   
                   
               
               
                 201229_s_at 
                 BC000422 
                 ARIH2 
                 ariadne homolog 2 
                 0.0395 
                 0.3941 
                 −1.2 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 213812_s_at 
                 AK024748 
                 CAMKK2 
                 calcium/calmodulin- 
                 0.0294 
                 0.3375 
                 −1.2 
               
               
                   
                   
                   
                 dependent 
                   
                   
                   
               
               
                   
                   
                   
                 protein kinase 
                   
                   
                   
               
               
                   
                   
                   
                 kinase 2, beta 
                   
                   
                   
               
               
                 201298_s_at 
                 BC003398 
                 MOBK1B 
                 MOB1, Mps One 
                 0.0077 
                 0.0700 
                 −1.2 
               
               
                   
                   
                   
                 Binder kinase 
                   
                   
                   
               
               
                   
                   
                   
                 activator-like 1B 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 213270_at 
                 AW450911 
                 MPP2 
                 membrane protein, 
                 0.0039 
                 0.0933 
                 −1.2 
               
               
                   
                   
                   
                 palmitoylated 2 
                   
                   
                   
               
               
                   
                   
                   
                 (MAGUK p55 
                   
                   
                   
               
               
                   
                   
                   
                 subfamily member 
                   
                   
                   
               
               
                   
                   
                   
                 2) 
                   
                   
                   
               
               
                 220688_s_at 
                 NM_016183 
                 MRT4 
                 mRNA turnover 4 
                 0.0046 
                 0.0441 
                 −1.2 
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 51176_at 
                 AA131335 
                 CRSP8 
                 cofactor required 
                 0.0015 
                 0.2747 
                 −1.2 
               
               
                   
                   
                   
                 for Sp1 
                   
                   
                   
               
               
                   
                   
                   
                 transcriptional 
                   
                   
                   
               
               
                   
                   
                   
                 activation, subunit 
                   
                   
                   
               
               
                   
                   
                   
                 8, 34 kDa 
                   
                   
                   
               
               
                 201761_at 
                 NM_006636 
                 MTHFD2 
                 methylenetetrahydrofolate 
                 0.0124 
                 0.6250 
                 −1.2 
               
               
                   
                   
                   
                 dehydrogenase 
                   
                   
                   
               
               
                   
                   
                   
                 (NADP+ 
                   
                   
                   
               
               
                   
                   
                   
                 dependent) 2, 
                   
                   
                   
               
               
                   
                   
                   
                 methenyltetrahydrofolate 
                   
                   
                   
               
               
                   
                   
                   
                 cyclohydrolase 
                   
                   
                   
               
               
                 208682_s_at 
                 AF126181 
                 MAGED2 
                 melanoma antigen 
                 0.0172 
                 0.3256 
                 −1.2 
               
               
                   
                   
                   
                 family D, 2 
                   
                   
                   
               
               
                 41160_at 
                 AC005943 
                 MBD3 
                 methyl-CpG 
                 0.0031 
                 0.0383 
                 −1.2 
               
               
                   
                   
                   
                 binding domain 
                   
                   
                   
               
               
                   
                   
                   
                 protein 3 
                   
                   
                   
               
               
                 205661_s_at 
                 NM_025207 
                 FLAD1 
                 FAD1 flavin 
                 0.0063 
                 0.8074 
                 −1.2 
               
               
                   
                   
                   
                 adenine 
                   
                   
                   
               
               
                   
                   
                   
                 dinucleotide 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 208821_at 
                 J04564 
                 SNRPB 
                 small nuclear 
                 0.0050 
                 0.0642 
                 −1.2 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptides B and 
                   
                   
                   
               
               
                   
                   
                   
                 B1 
                   
                   
                   
               
               
                 201303_at 
                 NM_014740 
                 EIF4A3 
                 eukaryotic 
                 0.0079 
                 0.9084 
                 −1.2 
               
               
                   
                   
                   
                 translation 
                   
                   
                   
               
               
                   
                   
                   
                 initiation factor 
                   
                   
                   
               
               
                   
                   
                   
                 4A, isoform 3 
                   
                   
                   
               
               
                 209581_at 
                 BC001387 
                 HRASLS3 
                 HRAS-like 
                 0.0335 
                 0.1759 
                 −1.2 
               
               
                   
                   
                   
                 suppressor 3 
                   
                   
                   
               
               
                 48531_at 
                 AA522816 
                 TNIP2 
                 TNFAIP3 
                 0.0131 
                 0.4345 
                 −1.2 
               
               
                   
                   
                   
                 interacting protein 2 
                   
                   
                   
               
               
                 201697_s_at 
                 NM_001379 
                 DNMT1 
                 DNA (cytosine-5-)- 
                 0.0193 
                 0.1580 
                 −1.2 
               
               
                   
                   
                   
                 methyltransferase 1 
                   
                   
                   
               
               
                 218019_s_at 
                 NM_021941 
                 PDXK 
                 pyridoxal 
                 0.0044 
                 0.0638 
                 −1.2 
               
               
                   
                   
                   
                 (pyridoxine, 
                   
                   
                   
               
               
                   
                   
                   
                 vitamin B6) kinase 
                   
                   
                   
               
               
                 202338_at 
                 NM_003258 
                 TK1 
                 thymidine kinase 1, 
                 0.0295 
                 0.0858 
                 −1.2 
               
               
                   
                   
                   
                 soluble 
                   
                   
                   
               
               
                 216232_s_at 
                 AI697055 
                 GCN1L1 
                 GCN1 general 
                 0.0066 
                 0.1082 
                 −1.2 
               
               
                   
                   
                   
                 control of amino- 
                   
                   
                   
               
               
                   
                   
                   
                 acid synthesis 1- 
                   
                   
                   
               
               
                   
                   
                   
                 like 1 (yeast) 
                   
                   
                   
               
               
                 212250_at 
                 AV700332 
                 MTDH 
                 metadherin 
                 0.0380 
                 0.1082 
                 −1.2 
               
               
                 214771_x_at 
                 AK025604 
                 M-RIP 
                 myosin 
                 0.0146 
                 0.3146 
                 −1.2 
               
               
                   
                   
                   
                 phosphatase-Rho 
                   
                   
                   
               
               
                   
                   
                   
                 interacting protein 
                   
                   
                   
               
               
                 200683_s_at 
                 BE964689 
                 UBE2L3 
                 ubiquitin- 
                 0.0214 
                 0.9367 
                 −1.2 
               
               
                   
                   
                   
                 conjugating 
                   
                   
                   
               
               
                   
                   
                   
                 enzyme E2L 3 
                   
                   
                   
               
               
                 208152_s_at 
                 NM_004728 
                 DDX21 
                 DEAD (Asp-Glu- 
                 0.0325 
                 0.1335 
                 −1.2 
               
               
                   
                   
                   
                 Ala-Asp) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 21 /// 
                   
                   
                   
               
               
                   
                   
                   
                 DEAD (Asp-Glu- 
                   
                   
                   
               
               
                   
                   
                   
                 Ala-Asp) box 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide 21 
                   
                   
                   
               
               
                 203828_s_at 
                 NM_004221 
                 IL32 
                 interleukin 32 /// 
                 0.0114 
                 0.0452 
                 −1.2 
               
               
                   
                   
                   
                 interleukin 32 
                   
                   
                   
               
               
                 208777_s_at 
                 AF001212 
                 PSMD11 
                 proteasome 
                 0.0066 
                 0.2440 
                 −1.2 
               
               
                   
                   
                   
                 (prosome, 
                   
                   
                   
               
               
                   
                   
                   
                 macropain) 26S 
                   
                   
                   
               
               
                   
                   
                   
                 subunit, non- 
                   
                   
                   
               
               
                   
                   
                   
                 ATPase, 11 
                   
                   
                   
               
               
                 219862_s_at 
                 NM_012336 
                 NARF 
                 nuclear prelamin A 
                 0.0278 
                 0.9051 
                 −1.2 
               
               
                   
                   
                   
                 recognition factor 
                   
                   
                   
               
               
                 203827_at 
                 NM_017983 
                 WIPI1 
                 WD repeat domain, 
                 0.0081 
                 0.4544 
                 −1.2 
               
               
                   
                   
                   
                 phosphoinositide 
                   
                   
                   
               
               
                   
                   
                   
                 interacting 1 
                   
                   
                   
               
               
                 219491_at 
                 NM_024036 
                 LRFN4 
                 leucine rich repeat 
                 0.0160 
                 0.3821 
                 −1.2 
               
               
                   
                   
                   
                 and fibronectin 
                   
                   
                   
               
               
                   
                   
                   
                 type III domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 4 
                   
                   
                   
               
               
                 202115_s_at 
                 NM_015658 
                 NOC2L 
                 nucleolar complex 
                 0.0326 
                 0.6859 
                 −1.2 
               
               
                   
                   
                   
                 associated 2 
                   
                   
                   
               
               
                   
                   
                   
                 homolog ( S. cerevisiae ) 
                   
                   
                   
               
               
                 212098_at 
                 AL134724 
                 LOC151162 
                 hypothetical 
                 0.0094 
                 0.4141 
                 −1.2 
               
               
                   
                   
                   
                 protein 
                   
                   
                   
               
               
                   
                   
                   
                 LOC151162 
                   
                   
                   
               
               
                 203570_at 
                 NM_005576 
                 LOXL1 
                 lysyl oxidase-like 1 
                 0.0023 
                 0.0499 
                 −1.2 
               
               
                 210213_s_at 
                 AF022229 
                 ITGB4BP 
                 integrin beta 4 
                 0.0097 
                 0.2297 
                 −1.2 
               
               
                   
                   
                   
                 binding protein 
                   
                   
                   
               
               
                 32836_at 
                 U56417 
                 AGPAT1 
                 1-acylglycerol-3- 
                 0.0161 
                 0.0474 
                 −1.2 
               
               
                   
                   
                   
                 phosphate O- 
                   
                   
                   
               
               
                   
                   
                   
                 acyltransferase 1 
                   
                   
                   
               
               
                   
                   
                   
                 (lysophosphatidic 
                   
                   
                   
               
               
                   
                   
                   
                 acid 
                   
                   
                   
               
               
                   
                   
                   
                 acyltransferase, 
                   
                   
                   
               
               
                   
                   
                   
                 alpha) 
                   
                   
                   
               
               
                 201284_s_at 
                 NM_001640 
                 APEH 
                 N-acylaminoacyl- 
                 0.0120 
                 0.0383 
                 −1.2 
               
               
                   
                   
                   
                 peptide hydrolase 
                   
                   
                   
               
               
                 208689_s_at 
                 BC003560 
                 RPN2 
                 ribophorin II 
                 0.0060 
                 0.0452 
                 −1.2 
               
               
                 201307_at 
                 AL534972 
                 11-Sep 
                 septin 11 
                 0.0200 
                 0.7860 
                 −1.2 
               
               
                 202757_at 
                 NM_015456 
                 COBRA1 
                 cofactor of BRCA1 
                 0.0030 
                 0.0278 
                 −1.2 
               
               
                 212480_at 
                 AB002374 
                 SPECC1L 
                 SPECC1-like 
                 0.0411 
                 0.1914 
                 −1.2 
               
               
                 203233_at 
                 NM_000418 
                 IL4R 
                 interleukin 4 
                 0.0148 
                 0.4358 
                 −1.2 
               
               
                   
                   
                   
                 receptor 
                   
                   
                   
               
               
                 211630_s_at 
                 L42531 
                 GSS 
                 glutathione 
                 0.0411 
                 0.1844 
                 −1.2 
               
               
                   
                   
                   
                 synthetase /// 
                   
                   
                   
               
               
                   
                   
                   
                 glutathione 
                   
                   
                   
               
               
                   
                   
                   
                 synthetase 
                   
                   
                   
               
               
                 212400_at 
                 AL043266 
                 FAM102A 
                 family with 
                 0.0194 
                 0.2054 
                 −1.2 
               
               
                   
                   
                   
                 sequence similarity 
                   
                   
                   
               
               
                   
                   
                   
                 102, member A 
                   
                   
                   
               
               
                 221704_s_at 
                 BC005882 
                 VPS37B 
                 vacuolar protein 
                 0.0045 
                 0.6051 
                 −1.2 
               
               
                   
                   
                   
                 sorting 37 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 B ( S. cerevisiae ) /// 
                   
                   
                   
               
               
                   
                   
                   
                 vacuolar protein 
                   
                   
                   
               
               
                   
                   
                   
                 sorting 37 homolog 
                   
                   
                   
               
               
                   
                   
                   
                 B ( S. cerevisiae ) 
                   
                   
                   
               
               
                 209452_s_at 
                 AF035824 
                 VTI1B 
                 vesicle transport 
                 0.0357 
                 0.4069 
                 −1.2 
               
               
                   
                   
                   
                 through interaction 
                   
                   
                   
               
               
                   
                   
                   
                 with t-SNAREs 
                   
                   
                   
               
               
                   
                   
                   
                 homolog 1B 
                   
                   
                   
               
               
                   
                   
                   
                 (yeast) 
                   
                   
                   
               
               
                 218758_s_at 
                 NM_003683 
                 D21S2056E 
                 DNA segment on 
                 0.0362 
                 0.3701 
                 −1.2 
               
               
                   
                   
                   
                 chromosome 21 
                   
                   
                   
               
               
                   
                   
                   
                 (unique) 2056 
                   
                   
                   
               
               
                   
                   
                   
                 expressed sequence 
                   
                   
                   
               
               
                 201361_at 
                 NM_024092 
                 TMEM109 
                 transmembrane 
                 0.0256 
                 0.2193 
                 −1.2 
               
               
                   
                   
                   
                 protein 109 
                   
                   
                   
               
               
                 209323_at 
                 AF081567 
                 PRKRIR 
                 protein-kinase, 
                 0.0063 
                 0.0537 
                 −1.2 
               
               
                   
                   
                   
                 interferon- 
                   
                   
                   
               
               
                   
                   
                   
                 inducible double 
                   
                   
                   
               
               
                   
                   
                   
                 stranded RNA 
                   
                   
                   
               
               
                   
                   
                   
                 dependent 
                   
                   
                   
               
               
                   
                   
                   
                 inhibitor, repressor 
                   
                   
                   
               
               
                   
                   
                   
                 of (P58 repressor) 
                   
                   
                   
               
               
                 204080_at 
                 NM_025077 
                 TOE1 
                 target of EGR1, 
                 0.0179 
                 0.7025 
                 −1.2 
               
               
                   
                   
                   
                 member 1 (nuclear) 
                   
                   
                   
               
               
                 200708_at 
                 NM_002080 
                 GOT2 
                 glutamic- 
                 0.0021 
                 0.6983 
                 −1.2 
               
               
                   
                   
                   
                 oxaloacetic 
                   
                   
                   
               
               
                   
                   
                   
                 transaminase 2, 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                   
                   
                   
                 (aspartate 
                   
                   
                   
               
               
                   
                   
                   
                 aminotransferase 
                   
                   
                   
               
               
                   
                   
                   
                 2) 
                   
                   
                   
               
               
                 220155_s_at 
                 NM_023924 
                 BRD9 
                 bromodomain 
                 0.0014 
                 0.0804 
                 −1.2 
               
               
                   
                   
                   
                 containing 9 
                   
                   
                   
               
               
                 211456_x_at 
                 AF333388 
                 LOC645745 
                 metallothionein 
                 0.0037 
                 0.0589 
                 −1.2 
               
               
                   
                   
                   
                 1H-like protein 
                   
                   
                   
               
               
                 218460_at 
                 NM_017802 
                 HEATR2 
                 HEAT repeat 
                 0.0180 
                 0.7292 
                 −1.2 
               
               
                   
                   
                   
                 containing 2 
                   
                   
                   
               
               
                 200793_s_at 
                 NM_001098 
                 ACO2 
                 aconitase 2, 
                 0.0358 
                 0.1897 
                 −1.2 
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 203149_at 
                 NM_002856 
                 PVRL2 
                 poliovirus 
                 0.0356 
                 0.5506 
                 −1.2 
               
               
                   
                   
                   
                 receptor-related 2 
                   
                   
                   
               
               
                   
                   
                   
                 (herpesvirus entry 
                   
                   
                   
               
               
                   
                   
                   
                 mediator B) 
                   
                   
                   
               
               
                 201066_at 
                 NM_001916 
                 CYC1 
                 cytochrome c-1 
                 0.0069 
                 0.7513 
                 −1.2 
               
               
                 207707_s_at 
                 NM_030673 
                 SEC13 
                 SEC13 homolog 
                 0.0025 
                 0.4694 
                 −1.2 
               
               
                   
                   
                   
                 ( S. cerevisiae ) 
                   
                   
                   
               
               
                 205351_at 
                 NM_000821 
                 GGCX 
                 gamma-glutamyl 
                 0.0093 
                 0.8819 
                 −1.2 
               
               
                   
                   
                   
                 carboxylase 
                   
                   
                   
               
               
                 214437_s_at 
                 NM_005412 
                 SHMT2 
                 serine 
                 0.0054 
                 0.2573 
                 −1.2 
               
               
                   
                   
                   
                 hydroxymethyltransferase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (mitochondrial) 
                   
                   
                   
               
               
                 208863_s_at 
                 M72709 
                 SFRS1 
                 splicing factor, 
                 0.0136 
                 0.1920 
                 −1.2 
               
               
                   
                   
                   
                 arginine/serine-rich 
                   
                   
                   
               
               
                   
                   
                   
                 1 (splicing factor 2, 
                   
                   
                   
               
               
                   
                   
                   
                 alternate splicing 
                   
                   
                   
               
               
                   
                   
                   
                 factor) 
                   
                   
                   
               
               
                 209501_at 
                 AL582414 
                 CDR2 
                 cerebellar 
                 0.0186 
                 0.1069 
                 −1.2 
               
               
                   
                   
                   
                 degeneration- 
                   
                   
                   
               
               
                   
                   
                   
                 related protein 2, 
                   
                   
                   
               
               
                   
                   
                   
                 62 kDa 
                   
                   
                   
               
               
                 206809_s_at 
                 NM_005758 
                 HNRPA3P1 
                 heterogeneous 
                 0.0275 
                 0.1782 
                 −1.2 
               
               
                   
                   
                 /// 
                 nuclear 
                   
                   
                   
               
               
                   
                   
                 HNRPA3 
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 A3 pseudogene 1 
                   
                   
                   
               
               
                   
                   
                   
                 /// heterogeneous 
                   
                   
                   
               
               
                   
                   
                   
                 nuclear 
                   
                   
                   
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 A3 
                   
                   
                   
               
               
                 205055_at 
                 NM_002208 
                 ITGAE 
                 integrin, alpha E 
                 0.0225 
                 0.0929 
                 −1.2 
               
               
                   
                   
                   
                 (antigen CD103, 
                   
                   
                   
               
               
                   
                   
                   
                 human mucosal 
                   
                   
                   
               
               
                   
                   
                   
                 lymphocyte 
                   
                   
                   
               
               
                   
                   
                   
                 antigen 1; alpha 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide) 
                   
                   
                   
               
               
                 216977_x_at 
                 AJ130972 
                 SNRPA1 
                 small nuclear 
                 0.0159 
                 0.2202 
                 −1.2 
               
               
                   
                   
                   
                 ribonucleoprotein 
                   
                   
                   
               
               
                   
                   
                   
                 polypeptide A′ 
                   
                   
                   
               
               
                 35617_at 
                 U29725 
                 MAPK7 
                 mitogen-activated 
                 0.0203 
                 0.2536 
                 −1.2 
               
               
                   
                   
                   
                 protein kinase 7 
                   
                   
                   
               
               
                 205546_s_at 
                 NM_003331 
                 TYK2 
                 tyrosine kinase 2 
                 0.0369 
                 0.1604 
                 −1.2 
               
               
                 212953_x_at 
                 BE251303 
                 CALR 
                 calreticulin 
                 0.0294 
                 0.1004 
                 −1.2 
               
               
                 211168_s_at 
                 D86988 
                 UPF1 
                 UPF1 regulator of 
                 0.0155 
                 0.0625 
                 −1.2 
               
               
                   
                   
                   
                 nonsense 
                   
                   
                   
               
               
                   
                   
                   
                 transcripts 
                   
                   
                   
               
               
                   
                   
                   
                 homolog (yeast) 
                   
                   
                   
               
               
                 210046_s_at 
                 U52144 
                 IDH2 
                 isocitrate 
                 0.0035 
                 0.0383 
                 −1.2 
               
               
                   
                   
                   
                 dehydrogenase 2 
                   
                   
                   
               
               
                   
                   
                   
                 (NADP+), 
                   
                   
                   
               
               
                   
                   
                   
                 mitochondrial 
                   
                   
                   
               
               
                 219933_at 
                 NM_016066 
                 GLRX2 
                 glutaredoxin 2 
                 0.0255 
                 0.1890 
                 −1.2 
               
               
                 219081_at 
                 NM_024668 
                 ANKHD1 
                 ankyrin repeat and 
                 0.0196 
                 0.4240 
                 −1.2 
               
               
                   
                   
                   
                 KH domain 
                   
                   
                   
               
               
                   
                   
                   
                 containing 1 
                   
                   
                   
               
               
                 200614_at 
                 NM_004859 
                 CLTC 
                 clathrin, heavy 
                 0.0237 
                 0.4039 
                 −1.2 
               
               
                   
                   
                   
                 chain (Hc) 
                   
                   
                   
               
               
                 209394_at 
                 BC002508 
                 ASMTL 
                 acetylserotonin O- 
                 0.0416 
                 0.4632 
                 −1.2 
               
               
                   
                   
                   
                 methyltransferase- 
                   
                   
                   
               
               
                   
                   
                   
                 like 
                   
                   
                   
               
               
                 49077_at 
                 AL040538 
                 PPME1 
                 protein 
                 0.0049 
                 0.8306 
                 −1.2 
               
               
                   
                   
                   
                 phosphatase 
                   
                   
                   
               
               
                   
                   
                   
                 methylesterase 1 
                   
                   
                   
               
               
                 217933_s_at 
                 NM_015907 
                 LAP3 
                 leucine 
                 0.0034 
                 0.0252 
                 −1.2 
               
               
                   
                   
                   
                 aminopeptidase 3 
                   
                   
                   
               
               
                 215411_s_at 
                 AL008730 
                 TRAF3IP2 
                 TRAF3 interacting 
                 0.0099 
                 0.0383 
                 −1.2 
               
               
                   
                   
                   
                 protein 2 
                   
                   
                   
               
               
                 221904_at 
                 AI141670 
                 C3orf40 
                 chromosome 3 
                 0.0459 
                 0.2865 
                 −1.2 
               
               
                   
                   
                   
                 open reading frame 
                   
                   
                   
               
               
                   
                   
                   
                 40 
                   
                   
                   
               
               
                 206445_s_at 
                 NM_001536 
                 PRMT1 
                 protein arginine 
                 0.0019 
                 0.0740 
                 −1.2 
               
               
                   
                   
                   
                 methyltransferase 1 
                   
                   
                   
               
               
                 207071_s_at 
                 NM_002197 
                 ACO1 /// 
                 aconitase 1, soluble 
                 0.0173 
                 0.8523 
                 −1.2 
               
               
                   
                   
                 ANKRD15 
                 /// ankyrin repeat 
                   
                   
                   
               
               
                   
                   
                   
                 domain 15 
                   
                   
                   
               
               
                 213205_s_at 
                 AU159543 
                 RAD54L2 
                 RAD54-like 2 ( S. cerevisiae ) 
                 0.0124 
                 0.1547 
                 −1.2 
               
               
                 207614_s_at 
                 NM_003592 
                 CUL1 
                 cullin 1 
                 0.0268 
                 0.9630 
                 −1.2 
               
               
                 208712_at 
                 M73554 
                 CCND1 
                 cyclin D1 
                 0.0440 
                 0.1233 
                 −1.2 
               
               
                 205224_at 
                 NM_017503 
                 SURF2 
                 surfeit 2 
                 0.0311 
                 0.9687 
                 −1.2 
               
               
                 202655_at 
                 NM_006010 
                 ARMET 
                 arginine-rich, 
                 0.0067 
                 0.2238 
                 −1.2 
               
               
                   
                   
                   
                 mutated in early 
                   
                   
                   
               
               
                   
                   
                   
                 stage tumors 
                   
                   
                   
               
               
                 201463_s_at 
                 NM_006755 
                 TALDO1 
                 transaldolase 1 
                 0.0043 
                 0.6019 
                 −1.2 
               
               
                 205588_s_at 
                 NM_007045 
                 FGFR1OP 
                 FGFR1 oncogene 
                 0.0246 
                 0.0856 
                 −1.2 
               
               
                   
                   
                 /// C9orf4 
                 partner /// 
                   
                   
                   
               
               
                   
                   
                   
                 chromosome 9 
                   
                   
                   
               
               
                   
                   
                   
                 open reading frame 4 
                   
                   
                   
               
               
                 203746_s_at 
                 NM_005333 
                 HCCS 
                 holocytochrome c 
                 0.0080 
                 0.3313 
                 −1.2 
               
               
                   
                   
                   
                 synthase 
                   
                   
                   
               
               
                   
                   
                   
                 (cytochrome c 
                   
                   
                   
               
               
                   
                   
                   
                 heme-lyase) 
                   
                   
                   
               
               
                 202240_at 
                 NM_005030 
                 PLK1 
                 polo-like kinase 1 
                 0.0224 
                 0.0274 
                 −1.2 
               
               
                   
                   
                   
                 ( Drosophila ) 
                   
                   
                   
               
               
                 207939_x_at 
                 NM_006711 
                 RNPS1 
                 RNA binding 
                 0.0112 
                 0.2149 
                 −1.2 
               
               
                   
                   
                   
                 protein S1, serine- 
                   
                   
                   
               
               
                   
                   
                   
                 rich domain 
                   
                   
                   
               
               
                 202991_at 
                 NM_006804 
                 STARD3 
                 START domain 
                 0.0198 
                 0.5816 
                 −1.2 
               
               
                   
                   
                   
                 containing 3 
                   
                   
                   
               
               
                 218337_at 
                 NM_022749 
                 RAI16 
                 retinoic acid 
                 0.0370 
                 0.4464 
                 −1.2 
               
               
                   
                   
                   
                 induced 16 
                   
                   
                   
               
               
                 210821_x_at 
                 BC002703 
                 CENPA 
                 centromere protein A 
                 0.0221 
                 0.0915 
                 −1.2 
               
               
                 200853_at 
                 NM_002106 
                 H2AFZ 
                 H2A histone 
                 0.0135 
                 0.7942 
                 −1.2 
               
               
                   
                   
                   
                 family, member Z 
                   
                   
                   
               
               
                 209464_at 
                 AB011446 
                 AURKB 
                 aurora kinase B 
                 0.0121 
                 0.0981 
                 −1.2 
               
               
                   
               
               
                 Cells were treated with 0.35 μM compound 1 for 6, 36 and 72 hours before harvest and subject to Affymetrix gene microarray analysis. 
               
               
                 Each sample was run in duplicates. 
               
               
                 A two-way ANOVA mixed model: (Intensity ~ Treatment + Time + Treatment × Time + Error) was utilized to identify drug treatment effect as well as treatment and time interaction on the expression of genes. 
               
               
                 The genes identified as modulated by the drug are those with FDR p value &lt; 0.05 in either the Treatment effect or Treatment × Time interaction and the fold change between treatment group and DMSO control group is greater than 1.2 fold or less than −1.2 fold and total of 2056 probe sets were selected and only 1697 representative unique genes are listed in this Table with redundant probe sets removed. 
               
             
          
         
       
     
                                       TABLE 7                   Proteins modulated by compound 1 treatment in Rh41 cells.                    International Protein           Peptide   FirstOfdescription   Index   Swiss-protein ID               AFTGREFDELNPSAQR   SWISS-PROT: P16615-1   IPI00219078.1   P16615-1       (SEQ ID NO: 146)   REFSEQ_NP: NP_733765                   ENSEMBL: ENSP00000324892                   Tax_Id = 9606                   Splice isoform                   SERCA2B of P16615                   Sarcoplasmic/endoplasmic                   reticulum calcium                   ATPase 2               AHEGEIEDLALGPDGK   REFSEQ_NP: NP_037520   IPI00033349.1           LVTVGR   TREMBL: Q9UH94               (SEQ ID NO: 147)   ENSEMBL: ENSP00000260643                   Tax_Id = 9606                   Prolactin regulatory                   element-binding protein               AHIAQLCEK   SWISS-PROT: Q00610   IPI00024067.1   Q00610       (SEQ ID NO: 148)   REFSEQ_NP: NP_004850                   ENSEMBL: ENSP00000269122                   Tax_Id = 9606                   Clathrin heavy chain 1               AITGASLADIMAK   SWISS-PROT: P38663   IPI00220397.1   P38663       (SEQ ID NO: 149)   REFSEQ_NP: NP_000977                   ENSEMBL: ENSP00000265264                   Tax_Id = 9606                   60S ribosomal protein                   L24               ALGTEVIQLFPEK   SWISS-PROT: O95831-2   IPI00186214.1   O95831-2       (SEQ ID NO: 150)   REFSEQ_NP: NP_665812                   ENSEMBL: ENSP00000316320                   Tax_Id = 9606                   Splice isoform 2 of                   O95831 Programmed                   cell death protein 8                   mitochondrial precursor               ALMAAEDK   TREMBL: Q9Y427; Q07414   IPI00000230.1   Q9Y427; Q07414       (SEQ ID NO: 151)   ENSEMBL: ENSP00000267996                   Tax_Id = 9606                   Hypothetical protein               AMINLHIQK   SWISS-PROT: Q9NZ45   IPI00020510.1   Q9NZ45       (SEQ ID NO: 152)   REFSEQ_NP: NP_060934                   ENSEMBL: ENSP00000242476                   Tax_Id = 9606                   Uncharacterized                   hematopoietic                   stem/progenitor cells                   protein MDS029                   Uncharacterized                   hematopoietic                   stem/progenitor cells                   protein MDS029               AQSEAEKLAKERQEAE   SWISS-PROT: P35240-7   IPI00220313.1   P35240-7       EAKEALLQASR   ENSEMBL: ENSP00000314630               (SEQ ID NO: 153)   Tax_Id = 9606                   Splice isoform 7 of                   P35240 Merlin               ASGDSARPVLLQVAES   SWISS-PROT: Q9UJS0   IPI00007084.1   Q9UJS0       AYR   REFSEQ_NP: NP_055066               (SEQ ID NO: 154)   ENSEMBL: ENSP00000265631                   Tax_Id = 9606                   Calcium-binding                   mitochondrial carrier                   protein Aralar2               ASITALEAK   SWISS-PROT: P35579   IPI00019502.1   P35579       (SEQ ID NO: 155)   REFSEQ_NP: NP_002464                   TREMBL: Q99529; Q9UMJ0                   ENSEMBL: ENSP00000216181                   Tax_Id = 9606                   Myosin heavy chain                   nonmuscle type A               AVTSANIQEFAGCKK   SWISS-PROT: P04626   IPI00025072.1   P04626       (SEQ ID NO: 156)   REFSEQ_NP: NP_004439                   TREMBL: Q9UMK4; Q14256; Q9NP09                   ENSEMBL: ENSP00000269571                   Tax_Id = 9606                   Receptor protein-                   tyrosine kinase erbB-2                   precursor               DDTIYEDEDVKEAIR   SWISS-PROT: P14927   IPI00220416.1   P14927       (SEQ ID NO: 157)   REFSEQ_NP: NP_006285                   ENSEMBL: ENSP00000287022                   Tax_Id = 9606                   ubiquinol-cytochrome c                   reductase binding                   protein               DGGQEYVVK   SWISS-PROT: O60437   IPI00216295.1   O60437       (SEQ ID NO: 158)   REFSEQ_NP: NP_002696                   ENSEMBL: ENSP00000262369                   Tax_Id = 9606                   Periplakin               DKQMELLENK   REFSEQ_NP: NP_006401   IPI00107873.1   NP_006401       (SEQ ID NO: 159)   TREMBL: O60520; Q9BUP3                   ENSEMBL: ENSP00000227259                   Tax_Id = 9606                   Tat-interacting protein               DLKPENLLLASK   REFSEQ_NP: NP_751909   IPI00166707.1   NP_751909       (SEQ ID NO: 160)   TREMBL: Q8N4I3                   ENSEMBL: ENSP00000315599                   Tax_Id = 9606                   Calcium/calmodulin-                   dependent protein kinase               DPIYFTGLASEPGAR   SWISS-PROT: Q99523   IPI00016022.1   Q99523       (SEQ ID NO: 161)   Tax_Id = 9606 Sortilin                   precursor               DSIVHQAGMLK   SWISS-PROT: O15144   IPI00005161.1   O15144       (SEQ ID NO: 162)   REFSEQ_NP: NP_005722;                   NP_690601                   TREMBL: Q9P1D4                   ENSEMBL: ENSP00000327137                   Tax_Id = 9606                   ARP2/3 complex 34 kDa                   subunit               DVSSSTPPSVTSK   REFSEQ_NP: NP_036451   IPI00098365.1   NP_036451       (SEQ ID NO: 163)   TREMBL: Q8IXR3; Q96HP5;                   Q13433                   ENSEMBL: ENSP00000269187                   Tax_Id = 9606                   LIV-1 protein estrogen                   regulated               EGVREVFETATR   SWISS-PROT: P01121   IPI00000041.1   P01121       (SEQ ID NO: 164)   REFSEQ_NP: NP_004031                   ENSEMBL: ENSP00000272233                   Tax_Id = 9606                   Transforming protein                   RhoB               ELASLHDK   SWISS-PROT: O14662-2   IPI00220261.1   O14662-2       (SEQ ID NO: 165)   REFSEQ_NP: NP_003754                   ENSEMBL: ENSP00000287648;                   ENSP00000320106                   Tax_Id = 9606 Splice                   isoform A of O14662                   Syntaxin 16               ELISNSSDALDKIR   SWISS-PROT: P07900   IPI00217479.1   P07900       (SEQ ID NO: 166)   REFSEQ_NP: NP_005339                   TREMBL: Q96HX7; Q8TBA7;                   O75322                   ENSEMBL: ENSP00000216281                   Tax_Id = 9606                   heat shock 90 kDa                   protein 1 alpha               ELVSLKQEQQAFKEAA   REFSEQ_NP: NP_006816   IPI00141318.1           DTER   TREMBL: Q07065               (SEQ ID NO: 167)   ENSEMBL: ENSP00000312296                   Tax_Id = 9606                   P63 protein P63 protein               EMIPFAVVGSDHEYQV   TREMBL: Q9UHD8   IPI00155610.1   Q9UHD8       NGKR   Tax_Id = 9606 MLL               (SEQ ID NO: 168)   septin-like fusion protein                   MSF-A MLL septin-like                   fusion protein MSF-A               EQHGLQLQSEINQLHSK   REFSEQ_NP: NP_003557   IPI00020647.1           (SEQ ID NO: 169)   TREMBL: Q14221; Q15075                   ENSEMBL: ENSP00000218310;                   ENSP00000317955                   Tax_Id = 9606                   Endosome-associated                   protein Endosome-                   associated protein               FETEKNNGAGYFLEHL   SWISS-PROT: P31930   IPI00013847.1   P31930       AFKGTK   REFSEQ_NP: NP_003356               (SEQ ID NO: 170)   TREMBL: Q96DD2                   ENSEMBL: ENSP00000203407                   Tax_Id = 9606                   Ubiquinol-cytochrome C                   reductase complex core                   protein I mitochondrial                   precursor               FEVIEKPQA   SWISS-PROT: P18859   IPI00002521.1   P18859       (SEQ ID NO: 171)   REFSEQ_NP: NP_001676                   ENSEMBL: ENSP00000284971;                   ENSP00000318330                   Tax_Id = 9606 ATP                   synthase coupling factor                   6 mitochondrial                   precursor               FFDEESYSLLRK   SWISS-PROT: P51571   IPI00019385.1   P51571       (SEQ ID NO: 172)   REFSEQ_NP: NP_006271                   TREMBL: Q96BQ0                   Tax_Id = 9606                   Translocon-associated                   protein delta subunit                   precursor               FHDVLGNERPSAYMR   REFSEQ_XP: XP_086381   IPI00084819.2   XP_086381       (SEQ ID NO: 173)   ENSEMBL: ENSP00000326482                   Tax_Id = 9606                   similar to 40S                   RIBOSOMAL                   PROTEIN P40 (C10                   PROTEIN)               FKMPEMHFKAPK   SWISS-PROT: Q09666   IPI00021812.1   Q09666       (SEQ ID NO: 174)   ENSEMBL: ENSP00000244934                   Tax_Id = 9606                   Neuroblast                   differentiation associated                   protein AHNAK               FSAYIKNSNPALNDNL   SWISS-PROT: O00299   IPI00010896.1   O00299       EK   REFSEQ_NP: NP_001279               (SEQ ID NO: 175)   ENSEMBL: ENSP00000211475                   Tax_Id = 9606                   Chloride intracellular                   channel protein 1               FSFKKPFK   SWISS-PROT: P49006   IPI00220803.1   P49006       (SEQ ID NO: 176)   REFSEQ_NP: NP_075385                   ENSEMBL: ENSP00000310885                   Tax_Id = 9606                   MARCKS-like protein               GADDAMESSKPGPVQ   TREMBL: Q9UFL1; Q9BSE0   IPI00004806.1   Q9UFL1; Q9BSE0       VVLVQK   Tax_Id = 9606               (SEQ ID NO: 177)   Hypothetical protein               GALHTVSHEDIRDIR   REFSEQ_NP: NP_003617   IPI00164240.3   NP_003617       (SEQ ID NO: 178)   TREMBL: Q13136; Q8N4I2;                   Q14567                   ENSEMBL: ENSP00000310098                   Tax_Id = 9606                   PTPRF interacting                   protein alpha 1 isoform b               GFFGYK   TREMBL: Q15693   IPI00018949.1   Q15693       (SEQ ID NO: 179)   Tax_Id = 9606 5C5 5C5               GPASPLDSTFYR   SWISS-PROT: P04626   IPI00025072.1   P04626       (SEQ ID NO: 180)   REFSEQ_NP: NP_004439                   TREMBL: Q9UMK4; Q14256;                   Q9NP09                   ENSEMBL: ENSP00000269571                   Tax_Id = 9606                   Receptor protein-                   tyrosine kinase erbB-2                   precursor               GPVGTVSEAQLAR   SWISS-   IPI00021048.1   Q9NZM1-1       (SEQ ID NO: 181)   PROT: Q9NZM1-1                   REFSEQ_NP: NP_038479                   ENSEMBL: ENSP00000260690                   Tax_Id = 9606                   Splice isoform 1 of                   Q9NZM1 Myoferlin               GTPGPPPAHGAALQPH   SWISS-PROT: Q15654   IPI00018848.2   Q15654       PR   REFSEQ_NP: NP_003293               (SEQ ID NO: 182)   TREMBL: Q9BUE5; Q9BXP3                   ENSEMBL: ENSP00000200457                   Tax_Id = 9606                   Thyroid receptor                   interacting protein 6               GVGIISEGNETVEDIAA   SWISS-PROT: P05023-1   IPI00006482.1   P05023-1       RLNIPVSQVNPR   REFSEQ_NP: NP_000692               (SEQ ID NO: 183)   TREMBL: Q9UJ21                   ENSEMBL: ENSP00000295598                   Tax_Id = 9606                   Splice isoform Long of                   P05023                   Sodium/potassium-                   transporting ATPase                   alpha-1 chain precursor               GYSFTTTAER   SWISS-PROT: P02570   IPI00021439.1   P02570       (SEQ ID NO: 184)   REFSEQ_NP: NP_001092                   TREMBL: Q96DE1; Q96E67;                   Q9BTD2; Q9UE89;                   Q8WVW5; Q96FU6; Q96B34;                   Q9UMN3                   ENSEMBL: ENSP00000158302                   Tax_Id = 9606                   Actin cytoplasmic 1               HMGLFDHAAR   SWISS-PROT: P50213   IPI00030702.1   P50213       (SEQ ID NO: 185)   REFSEQ_NP: NP_005521                   TREMBL: Q9H3X0                   ENSEMBL: ENSP00000299518                   Tax_Id = 9606                   Isocitrate dehydrogenase                   [NAP] subunit alpha                   mitochondrial precursor               HSTFHGEDKLISVEDL   REFSEQ_NP: NP_003147   IPI00166512.1   NP_003147       WK   TREMBL: Q8N382               (SEQ ID NO: 186)   ENSEMBL: ENSP00000300737                   Tax_Id = 9606                   Hypothetical protein                   Hypothetical protein               HVIPMNPNTDDLFK   SWISS-PROT: P13797   IPI00216694.1   P13797       (SEQ ID NO: 187)   REFSEQ_NP: NP_005023                   TREMBL: Q96HI1                   ENSEMBL: ENSP00000289290                   Tax_Id = 9606                   plastin 3               IAAYAYSALSQIR   REFSEQ_NP: NP_060377   IPI00016670.1           (SEQ ID NO: 188)   TREMBL: Q9NWT0; Q8WZ09                   ENSEMBL: ENSP00000278671                   Tax_Id = 9606                   Hypothetical protein                   Hypothetical protein               IASQVAALDLGYKPGV   SWISS-PROT: P28331   IPI00002871.1   P28331       EAIR   Tax_Id = 9606 NADH-               (SEQ ID NO: 189)   ubiquinone                   oxidoreductase 75 kDa                   subunit mitochondrial                   precursor               IEVEKPFAIAKE   SWISS-PROT: P23284   IPI00107117.1   P23284       (SEQ ID NO: 190)   REFSEQ_NP: NP_000933                   TREMBL: Q9BVK5                   ENSEMBL: ENSP00000300026                   Tax_Id = 9606                   Peptidylprolyl isomerase B               IFVGGIKEDTEEHHLR   REFSEQ_XP: XP_018399   IPI00042578.1   XP_018399       (SEQ ID NO: 191)   ENSEMBL: ENSP00000267149                   Tax_Id = 9606                   similar to helix-                   destabilizing protein —rat               IHEKLHYYEK   REFSEQ_NP: NP_775767   IPI00217617.1   NP_775767       (SEQ ID NO: 192)   TREMBL: Q8IY28                   ENSEMBL: ENSP00000315639                   Tax_Id = 9606                   Similar to membrane                   protein palmitoylated 3               IINEPTAAAIAYGLDK   SWISS-PROT: P34931   IPI00002965.2   P34931       (SEQ ID NO: 193)   REFSEQ_NP: NP_005518                   TREMBL: Q8NE72                   REFSEQ_XP: XP_166348;                   XP_212623                   ENSEMBL: ENSP00000259871                   Tax_Id = 9606                   Heat shock 70 kDa                   protein 1-HOM               IISANGCK   SWISS-PROT: P05023-1   IPI00006482.1   P05023-1       (SEQ ID NO: 194)   REFSEQ_NP: NP_000692                   TREMBL: Q9UJ21                   ENSEMBL: ENSP00000295598                   Tax_Id = 9606                   Splice isoform Long of                   P05023                   Sodium/potassium-                   transporting ATPase                   alpha-1 chain precursor               IIYSHFTCATDTENIR   SWISS-PROT: P50148   IPI00097511.1   P50148       (SEQ ID NO: 195)   REFSEQ_NP: NP_002063                   TREMBL: Q9BZB9                   ENSEMBL: ENSP00000286548                   Tax_Id = 9606 G                   alpha q protein               INVYYNEATGGK   SWISS-PROT: P05217   IPI00007752.1   P05217       (SEQ ID NO: 196)   REFSEQ_NP: NP_006079                   TREMBL: Q96HX0; Q9BUU9                   Tax_Id = 9606                   Tubulin beta-2 chain                   Tubulin beta-2 chain               IPDVDIDSDGVFK   SWISS-PROT: Q9NRX4   IPI00156269.1   Q9NRX4       (SEQ ID NO: 197)   REFSEQ_NP: NP_054891                   TREMBL: Q9P019                   ENSEMBL: ENSP00000247665                   Tax_Id = 9606 14 kDa                   phosphohistidine                   phosphatase               ISVYYNEATGGKYVPR   REFSEQ_NP: NP_001060   IPI00013475.1           (SEQ ID NO: 198)   TREMBL: O43209; Q9UGA2;                   Q13885                   ENSEMBL: ENSP00000259799                   Tax_Id = 9606                   Beta tubulin               IYHTIAYLTPLPQPNR   SWISS-PROT: P10620   IPI00021805.1   P10620       (SEQ ID NO: 199)   REFSEQ_NP: NP_064696;                   NP_665707; NP_665734;                   NP_665735                   ENSEMBL: ENSP00000010404;                   ENSP00000314356;                   ENSP00000314383;                   ENSP00000314466                   Tax_Id = 9606                   Microsomal glutathione                   S-transferase 1               KAHLTNQYMQR   REFSEQ_XP: XP_210297   IPI00173545.1           (SEQ ID NO: 200)   Tax_Id = 9606 similar                   to Polyadenylate-binding                   protein 4 (Poly(A)                   binding protein 4)                   (PABP 4) (Inducible                   poly(A)-binding protein)                   (iPABP) (Activated-                   platelet protein-1) (APP-                   1)               KALELDQER   SWISS-PROT: P35241   IPI00017367.1   P35241       (SEQ ID NO: 201)   REFSEQ_NP: NP_002897                   TREMBL: Q9NST9                   ENSEMBL: ENSP00000282281;                   ENSP00000310481                   Tax_Id = 9606                   Radixin Radixin               KEPHESLGMTVAGGR   SWISS-PROT: Q8N448   IPI00171047.1   Q8N448       (SEQ ID NO: 202)   REFSEQ_NP: NP_699202                   ENSEMBL: ENSP00000266952;                   ENSP00000325929                   Tax_Id = 9606                   Numb-binding protein 2               KGLDPYNVLAPK   SWISS-PROT: P10606   IPI00021785.2   P10606       (SEQ ID NO: 203)   REFSEQ_NP: NP_001853                   TREMBL: Q99610                   ENSEMBL: ENSP00000258424                   Tax_Id = 9606                   Cytochrome c oxidase                   polypeptide Vb                   mitochondrial precursor               KIYEFTLQR   SWISS-PROT: O43795   IPI00013980.2   O43795       (SEQ ID NO: 204)   ENSEMBL: ENSP00000306382                   Tax_Id = 9606                   Myosin Ib               KLMEECKR   SWISS-PROT: Q9P0L0   IPI00170692.1   Q9P0L0       (SEQ ID NO: 205)   REFSEQ_NP: NP_003565                   ENSEMBL: ENSP00000217602                   Tax_Id = 9606                   Vesicle-associated                   membrane protein-                   associated protein A               KMMLDLNKAK   TREMBL: Q92799   IPI00023349.1   Q92799       (SEQ ID NO: 206)   Tax_Id = 9606                   Mitochondrial                   trifunctional protein beta                   subunit               KPQYDIWGNTVNVASR   SWISS-PROT: O95622   IPI00218608.1   O95622       (SEQ ID NO: 207)   ENSEMBL: ENSP00000308685                   Tax_Id = 9606                   Adenylate cyclase type V               KTGENVEDAFLEAAK   SWISS-PROT: P35287   IPI00017508.1   P35287       (SEQ ID NO: 208)   REFSEQ_NP: NP_057406                   ENSEMBL: ENSP00000238339                   Tax_Id = 9606                   Ras-related protein Rab-                   14 Ras-related protein                   Rab-14               KVEEENQGALEMIKR   TREMBL: Q8N4U4; Q8WU84   IPI00102860.1   Q8N4U4; Q8WU84       (SEQ ID NO: 209)   ENSEMBL: ENSP00000304043                   Tax_Id = 9606                   Hypothetical protein               KWESPAQNTAHLDQF   SWISS-PROT: P17612-1   IPI00219591.1   P17612-1       ER   REFSEQ_NP: NP_002721               (SEQ ID NO: 210)   TREMBL: Q15136                   ENSEMBL: ENSP00000263389                   Tax_Id = 9606                   protein kinase cAMP-                   dependent catalytic                   alpha               KYELGRPAANTK   SWISS-PROT: P09058   IPI00216587.1   P09058       (SEQ ID NO: 211)   REFSEQ_NP: NP_001003                   TREMBL: Q9BS10                   ENSEMBL: ENSP00000271105                   Tax_Id = 9606                   40S ribosomal protein                   S8 40S ribosomal                   protein S8               LAALQGRLEGLGSSEA   REFSEQ_NP: NP_006816   IPI00141318.1   NP_006816       DQDGLASTVR   TREMBL: Q07065               (SEQ ID NO: 212)   ENSEMBL: ENSP00000312296                   Tax_Id = 9606                   P63 protein P63 protein               LDHKFDLMYAK   SWISS-PROT: P05215   IPI00007750.1   P05215       (SEQ ID NO: 213)   REFSEQ_NP: NP_005991                   ENSEMBL: ENSP00000248437                   Tax_Id = 9606                   Tubulin alpha-4 chain               LDLRDDKDTIER   SWISS-PROT: O14658   IPI00023138.1   O14658       (SEQ ID NO: 214)   REFSEQ_NP: NP_005043                   ENSEMBL: ENSP00000304283                   Tax_Id = 9606                   Ras-related C3                   botulinum toxin                   substrate 3               LEKHELIEFR   SWISS-PROT: Q00610   IPI00024067.1   Q00610       (SEQ ID NO: 215)   REFSEQ_NP: NP_004850                   ENSEMBL: ENSP00000269122                   Tax_Id = 9606                   Clathrin heavy chain 1               LESEGSPETLTNLR   TREMBL: Q9NQA7   IPI00175830.1   Q9NQA7       (SEQ ID NO: 216)   Tax_Id = 9606 B-ind1                   protein B-ind1 protein               LHSLKTAK   SWISS-PROT: P20929   IPI00026247.2   P20929       (SEQ ID NO: 217)   REFSEQ_NP: NP_004534                   TREMBL: Q14215; Q14918;                   Q14214                   ENSEMBL: ENSP00000172853                   Tax_Id = 9606                   Nebulin Nebulin               LIVDEAINEDNSVVSLS   SWISS-PROT: P55072   IPI00022774.1   P55072       QPK   REFSEQ_NP: NP_009057               (SEQ ID NO: 218)   TREMBL: Q9NTC4; Q96IF9;                   Q9HAP1; Q9HAP0                   ENSEMBL: ENSP00000298001;                   ENSP00000312929;                   ENSP00000315065;                   ENSP00000318011                   Tax_Id = 9606                   Transitional endoplasmic                   reticulum ATPase               LMVHTVATFNSIK   SWISS-PROT: Q13813   IPI00015786.1   Q13813       (SEQ ID NO: 219)   REFSEQ_NP: NP_003118                   TREMBL: Q15324; Q9UG16                   ENSEMBL: ENSP00000238302;                   ENSP00000306097;                   ENSP00000319196                   Tax_Id = 9606 Spectrin                   alpha chain brain               LNESLDENFKK   TREMBL: Q96CV4; Q9Y2M8;   IPI00179326.1   Q96CV4; Q9Y2M8;       (SEQ ID NO: 220)   Q9H5F5       Q9H5F5           ENSEMBL: ENSP00000005260                   Tax_Id = 9606                   Similar to RIKEN cDNA                   1300006M19 gene                   Similar to RIKEN cDNA                   1300006M19 gene               LQQGYNAMGFSQGGQ   SWISS-PROT: P50897   IPI00002412.1   P50897       FLR   REFSEQ_NP: NP_000301               (SEQ ID NO: 221)   ENSEMBL: ENSP00000253546                   Tax_Id = 9606                   Palmitoyl-protein                   thioesterase 1 precursor               LQVELDNVTGLLSQSD   SWISS-PROT: P35579   IPI00019502.1   P35579       SK   REFSEQ_NP: NP_002464               (SEQ ID NO: 222)   TREMBL: Q99529; Q9UMJ0                   ENSEMBL: ENSP00000216181                   Tax_Id = 9606                   Myosin heavy chain                   nonmuscle type A               LTVMTDLEDKNEWK   SWISS-PROT: Q12907   IPI00009950.1   Q12907       (SEQ ID NO: 223)   REFSEQ_NP: NP_006807                   ENSEMBL: ENSP00000303366                   Tax_Id = 9606                   Vesicular integral-                   membrane protein VIP36                   precursor               MASGAANVVGPK   SWISS-PROT: Q92520   IPI00021923.1   Q92520       (SEQ ID NO: 224)   REFSEQ_NP: NP_055703                   REFSEQ_XP: XP_208425                   ENSEMBL: ENSP00000222764;                   ENSP00000310532                   Tax_Id = 9606                   Protein FAM3C                   precursor               MKETAENYLGHTAK   SWISS-PROT: P38646   IPI00007765.2   P38646       (SEQ ID NO: 225)   REFSEQ_NP: NP_004125                   TREMBL: Q8N1C8                   ENSEMBL: ENSP00000297185                   Tax_Id = 9606                   Stress-70 protein                   mitochondrial precursor               MNRPAPVEVTYK   REFSEQ_NP: NP_003454   IPI00020164.1   NP_003454       (SEQ ID NO: 226)   TREMBL: Q93096; O00648                   ENSEMBL: ENSP00000229983                   Tax_Id = 9606                   Protein tyrosine                   phosphatase                   PTPCAAX1               MSQVMREWEEAERQAK   SWISS-PROT: P05067-7   IPI00219187.1   P05067-7       (SEQ ID NO: 227)   Tax_Id = 9606 Splice                   isoform L-APP733 of                   P05067 Amyloid beta                   A4 protein precursor               NALLSLAK   SWISS-PROT: P04083   IPI00218918.1   P04083       (SEQ ID NO: 228)   REFSEQ_NP: NP_000691                   ENSEMBL: ENSP00000257497                   Tax_Id = 9606                   annexin I               NDITPLHVASK   SWISS-PROT: Q12955   IPI00025770.2   Q12955       (SEQ ID NO: 229)   REFSEQ_NP: NP_066267                   TREMBL: Q8NAK2                   ENSEMBL: ENSP00000280772;                   ENSP00000313984                   Tax_Id = 9606                   Ankyrin 3               NHPLHIRENR   REFSEQ_NP: NP_006835   IPI00009963.2   NP_006835       (SEQ ID NO: 230)   TREMBL: Q9UEB2; O43341;                   Q96F08                   ENSEMBL: ENSP00000263383                   Tax_Id = 9606                   Acetolactate synthase                   Acetolactate synthase               NIVHNYSEAEIK   REFSEQ_NP: NP_060427   IPI00100282.1   NP_060427       (SEQ ID NO: 231)   TREMBL: Q9NWK2; Q9H201                   ENSEMBL: ENSP00000268933                   Tax_Id = 9606                   Epsin 3 Epsin 3               NLDSTTVAVHGEEIYCK   SWISS-PROT: P21291   IPI00219674.1   P21291       (SEQ ID NO: 232)   REFSEQ_NP: NP_004069                   TREMBL: Q9BTA4                   ENSEMBL: ENSP00000290286                   Tax_Id = 9606                   cysteine and glycine-rich                   protein 1               NLGSINTELQDVQR   REFSEQ_NP: NP_004883   IPI00006865.1   NP_004883       (SEQ ID NO: 233)   TREMBL: O75396                   ENSEMBL: ENSP00000286336                   Tax_Id = 9606                   Vesicle trafficking                   protein SEC22B Vesicle                   trafficking protein                   SEC22B               NVLSLTNK   SWISS-PROT: P05556-2   IPI00107778.1   P05556-2       (SEQ ID NO: 234)   REFSEQ_NP: NP_389647                   Tax_Id = 9606 integrin                   beta 1 isoform 1B                   precursor               PAVSKGDGMR   SWISS-PROT: O94973   IPI00016621.1   O94973       (SEQ ID NO: 235)   REFSEQ_NP: NP_036437                   TREMBL: Q9UFK5                   Tax_Id = 9606 Adapter-                   related protein complex                   2 alpha 2 subunit               PGTEPLGTTK   SWISS-PROT: Q9Y6I9   IPI00006372.1   Q9Y6I9       (SEQ ID NO: 236)   REFSEQ_NP: NP_057010                   ENSEMBL: ENSP00000296478                   Tax_Id = 9606                   Putative secreted protein                   ZSIG11 precursor                   Putative secreted protein                   ZSIG11 precursor               PIHPVGGLR   SWISS-PROT: Q9HCU4   IPI00015346.1   Q9HCU4       (SEQ ID NO: 237)   REFSEQ_NP: NP_001399                   ENSEMBL: ENSP00000271332;                   ENSP00000319010                   Tax_Id = 9606                   Cadherin EGF LAG                   seven-pass G-type                   receptor 2 precursor               QVLLAQAEAEK   SWISS-PROT: Q14254   IPI00029625.1   Q14254       (SEQ ID NO: 238)   REFSEQ_NP: NP_004466                   ENSEMBL: ENSP00000254926                   Tax_Id = 9606                   Flotillin-2               QVTPDGESDEVGVIPS   SWISS-PROT: Q15700   IPI00019328.1   Q15700       KR   REFSEQ_NP: NP_001355               (SEQ ID NO: 239)   ENSEMBL: ENSP00000280241                   Tax_Id = 9606                   Channel associated                   protein of synapse-110               RKVDWLTEK   SWISS-PROT: P04765   IPI00025491.1   P04765       (SEQ ID NO: 240)   REFSEQ_NP: NP_001407                   TREMBL: Q9BRK6; Q9NZR9                   ENSEMBL: ENSP00000293831                   Tax_Id = 9606                   Eukaryotic initiation                   factor 4A-I               RLYWDDLKR   SWISS-PROT: P02786   IPI00022462.1   P02786       (SEQ ID NO: 241)   REFSEQ_NP: NP_003225                   ENSEMBL: ENSP00000265238                   Tax_Id = 9606                   Transferrin receptor                   protein 1               RNELVIR   SWISS-PROT: P11413-2   IPI00216008.1   P11413-2       (SEQ ID NO: 242)   Tax_Id = 9606 Splice                   isoform Long of P11413                   Glucose-6-phosphate 1-                   dehydrogenase               RSNTENLSQHFR   SWISS-   IPI00008918.1   Q9UHB6-1       (SEQ ID NO: 243)   PROT: Q9UHB6-1                   REFSEQ_NP: NP_057441                   ENSEMBL: ENSP00000293615                   Tax_Id = 9606                   Splice isoform Beta of                   Q9UHB6 Epithelial                   protein lost in neoplasm               RTPVQPNPIVYMMK   SWISS-PROT: O96000   IPI00220060.1   O96000       (SEQ ID NO: 244)   REFSEQ_NP: NP_004539                   TREMBL: Q96RX5                   ENSEMBL: ENSP00000268668                   Tax_Id = 9606                   NADH dehydrogenase                   (ubiquinone) 1 beta                   subcomplex 10 22 kDa               SALLAEMDKVEGHVA   SWISS-PROT: P33527-6   IPI00216265.1   P33527-6       IK   Tax_Id = 9606 Splice               (SEQ ID NO: 245)   isoform Delexon-17-30                   of P33527 Multidrug                   resistance-associated                   protein 1               SAVTTVVNPK   SWISS-PROT: P05556-2   IPI00107778.1   P05556-2       (SEQ ID NO: 246)   REFSEQ_NP: NP_389647                   Tax_Id = 9606 integrin                   beta 1 isoform 1B                   precursor               SEESVSRLPEEIR   REFSEQ_NP: NP_006816   IPI00141318.1   NP_006816       (SEQ ID NO: 247)   TREMBL: Q07065                   ENSEMBL: ENSP00000312296                   Tax_Id = 9606                   P63 protein P63 protein               SEHKVWSPLVTEEGKR   SWISS-PROT: O00151   IPI00010414.2   O00151       (SEQ ID NO: 248)   REFSEQ_NP: NP_066272                   ENSEMBL: ENSP00000265995                   Tax_Id = 9606                   PDZ and LIM domain                   protein 1               SHEAEVLK   SWISS-PROT: P16949   IPI00031736.1   P16949       (SEQ ID NO: 249)   REFSEQ_NP: NP_005554                   TREMBL: Q96CE4                   ENSEMBL: ENSP00000236291                   Tax_Id = 9606                   Stathmin               SKEPQLIAFYHK   SWISS-PROT: P19634   IPI00020060.1   P19634       (SEQ ID NO: 250)   REFSEQ_NP: NP_003038                   REFSEQ_XP: XP_046881                   ENSEMBL: ENSP00000263980                   Tax_Id = 9606                   Sodium/hydrogen                   exchanger 1               SLSLSKLEDPHVDIIR   TREMBL: Q8TEP9   IPI00152791.1   Q8TEP9       (SEQ ID NO: 251)   Tax_Id = 9606 FLJ00144                   protein               SLVNQQSFQDIKPMR   SWISS-PROT: P17964   IPI00018364.2   P17964       (SEQ ID NO: 252)   REFSEQ_XP: XP_209564                   ENSEMBL: ENSP00000319096                   Tax_Id = 9606                   Ras-related protein RAP-                   2b Ras-related protein                   RAP-2b               SQVLDDEDSNNITVGS   SWISS-PROT: Q9UGP8   IPI00218922.1   Q9UGP8       LVTVLVK   REFSEQ_NP: NP_009145               (SEQ ID NO: 253)   TREMBL: Q8IWL0                   ENSEMBL: ENSP00000027474;                   ENSP00000317581                   Tax_Id = 9606                   SEC63 endoplasmic                   reticulum translocon                   component (S. cerevisiae)                   like               SRKESYSVYVYK   REFSEQ_XP: XP_169343   IPI00147570.1           (SEQ ID NO: 254)   Tax_Id = 9606 similar                   to H2B histone family                   member S               SSSLDDTEVKK   SWISS-PROT: O95292-1   IPI00006211.1   O95292-1       (SEQ ID NO: 255)   REFSEQ_NP: NP_004729                   ENSEMBL: ENSP00000265619                   Tax_Id = 9606                   Splice isoform 1 of                   O95292 Vesicle-                   associated membrane                   protein-associated                   protein B/C               STGPGASLGTGYDRK   SWISS-PROT: O15551   IPI00007364.1   O15551       (SEQ ID NO: 256)   REFSEQ_NP: NP_001297                   ENSEMBL: ENSP00000297926                   Tax_Id = 9606                   Claudin-3               SWEQKLEEMR   SWISS-PROT: Q16543   IPI00013122.1   Q16543       (SEQ ID NO: 257)   REFSEQ_NP: NP_008996                   ENSEMBL: ENSP00000222005                   Tax_Id = 9606                   Hsp90 co-chaperone                   Cdc37               TAPYKNVNIQNFHISWK   SWISS-PROT: P12814   IPI00025845.1   P12814       (SEQ ID NO: 258)   Tax_Id = 9606 Alpha-                   actinin 1               TAVVVGTITDDVR   SWISS-PROT: Q07020   IPI00215719.1   Q07020       (SEQ ID NO: 259)   REFSEQ_NP: NP_000970                   ENSEMBL: ENSP00000084795                   Tax_Id = 9606                   60S ribosomal protein                   L18 60S ribosomal                   protein L18               TDLEKDIISDTSGDFRK   SWISS-PROT: P07355   IPI00216240.1   P07355       (SEQ ID NO: 260)   REFSEQ_NP: NP_004030                   TREMBL: Q8TBV2                   ENSEMBL: ENSP00000316276                   Tax_Id = 9606                   Annexin A2 Annexin A2               TDPVDIYK   SWISS-PROT: P46940   IPI00009342.1   P46940       (SEQ ID NO: 261)   REFSEQ_NP: NP_003861                   TREMBL: Q96PA3                   ENSEMBL: ENSP00000268182                   Tax_Id = 9606                   Ras GTPase-activating-                   like protein IQGAP1               TKTEISEMNR   REFSEQ_NP: NP_778238   IPI00174775.1   NP_778238       (SEQ ID NO: 262)   ENSEMBL: ENSP00000307014                   Tax_Id = 9606                   keratin 6 irs3               TVFDEAIR   SWISS-PROT: P15154-2   IPI00219675.1   P15154-2       (SEQ ID NO: 263)   REFSEQ_NP: NP_061485                   ENSEMBL: ENSP00000258736                   Tax_Id = 9606                   Splice isoform B of                   P15154 Ras-related C3                   botulinum toxin                   substrate 1               TVNMTWNK   SWISS-PROT: P46939   IPI00009329.1   P46939       (SEQ ID NO: 264)   REFSEQ_NP: NP_009055                   TREMBL: Q9UJA7; Q8WYB8;                   Q8WYB7                   ENSEMBL: ENSP00000282749                   Tax_Id = 9606                   Utrophin               TVYSHLFDHVVNR   SWISS-PROT: Q9UM54   IPI00008455.1   Q9UM54       (SEQ ID NO: 265)   ENSEMBL: ENSP00000265377                   Tax_Id = 9606                   Myosin VI Myosin VI               VKANLEK   SWISS-PROT: P35579   IPI00019502.1   P35579       (SEQ ID NO: 266)   REFSEQ_NP: NP_002464                   TREMBL: Q99529; Q9UMJ0                   ENSEMBL: ENSP00000216181                   Tax_Id = 9606                   Myosin heavy chain                   nonmuscle type A               VKDASPNQVAEK   SWISS-PROT: O43402   IPI00005740.1   O43402       (SEQ ID NO: 267)   REFSEQ_NP: NP_006058                   ENSEMBL: ENSP00000253457                   Tax_Id = 9606                   Neighbor of COX4                   Neighbor of COX4               VKDRDDFPVVLVGNK   SWISS-PROT: P10301   IPI00020418.1   P10301       (SEQ ID NO: 268)   REFSEQ_NP: NP_006261                   ENSEMBL: ENSP00000246792                   Tax_Id = 9606                   Ras-related protein R-                   Ras               VKKEWEEAELQAK   SWISS-PROT: Q06481-3   IPI00220978.1   Q06481-3       (SEQ ID NO: 269)   ENSEMBL: ENSP00000263575                   Tax_Id = 9606                   Splice isoform 3 of                   Q06481 Amyloid-like                   protein 2 precursor               VKLFYLDPDAQKLDFS   SWISS-PROT: Q9BZ29-1   IPI00151888.2   Q9BZ29-1       SAEPEVK   REFSEQ_NP: NP_056111               (SEQ ID NO: 270)   TREMBL: Q9BZ26                   ENSEMBL: ENSP00000304814                   Tax_Id = 9606                   Splice isoform 1 of                   Q9BZ29 Cdc42 guanine                   nucleotide exchange                   factor zizimin 1               VLAFTAVGDGPPSPTIQ   REFSEQ_NP: NP_569707   IPI00107831.1           VK   ENSEMBL: ENSP00000318349               (SEQ ID NO: 271)   Tax_Id = 9606                   protein tyrosine                   phosphatase receptor                   type F isoform 2                   precursor               VNGRPLEMIEPR   SWISS-PROT: P17008   IPI00221092.1   P17008       (SEQ ID NO: 272)   REFSEQ_NP: NP_001011                   ENSEMBL: ENSP00000251453                   Tax_Id = 9606                   ribosomal protein S16               VPTSMVLTK   TREMBL: Q9H1H3; Q9ULE9   IPI00020719.1   Q9H1H3; Q9ULE9       (SEQ ID NO: 273)   REFSEQ_XP: XP_045472                   ENSEMBL: ENSP00000319445                   Tax_Id = 9606                   Hypothetical protein                   KIAA1271               VSSLGKDWHK   SWISS-PROT: P52943   IPI00006034.1   P52943       (SEQ ID NO: 274)   REFSEQ_NP: NP_001303                   Tax_Id = 9606                   Cysteine-rich protein 2               WEVEEMKESK   SWISS-PROT: P27824   IPI00020984.1   P27824       (SEQ ID NO: 275)   REFSEQ_NP: NP_001737                   ENSEMBL: ENSP00000247461                   Tax_Id = 9606                   Calnexin precursor               WGKPHVASLSFR   SWISS-PROT: P04920-1   IPI00026298.2   P04920-1       (SEQ ID NO: 276)   Tax_Id = 9606 Splice                   isoform A of P04920                   Anion exchange protein 2               WILSQTHNIFTQAGVR   REFSEQ_NP: NP_598003   IPI00171632.1           (SEQ ID NO: 277)   TREMBL: Q8TCH2; Q8NEW0                   ENSEMBL: ENSP00000294731                   Tax_Id = 9606                   Zinc transporter ZnT-7                   Zinc transporter ZnT-7               WKAGLYGLPRR   REFSEQ_NP: NP_004095   IPI00107774.1           (SEQ ID NO: 278)   TREMBL: Q96IT0; Q969R1;                   Q16702; Q96C68; Q13479;                   Q13587                   ENSEMBL: ENSP00000304592;                   ENSP00000304718                   Tax_Id = 9606 Fatty                   acid synthase               YGPSLMPGGNKEAWP   SWISS-PROT: P52209   IPI00219525.1   P52209       HIK   REFSEQ_NP: NP_002622               (SEQ ID NO: 279)   ENSEMBL: ENSP00000322397                   Tax_Id = 9606                   phosphogluconate                   dehydrogenase               YKVEGFPTIYFAPSGD   SWISS-PROT: P13667   IPI00009904.1   P13667       KK   REFSEQ_NP: NP_004902               (SEQ ID NO: 280)   ENSEMBL: ENSP00000286091                   Tax_Id = 9606                   Protein disulfide                   isomerase A4 precursor               YMGDLSGGQVLKK   SWISS-PROT: P30519   IPI00026824.1   P30519       (SEQ ID NO: 281)   REFSEQ_NP: NP_002125                   ENSEMBL: ENSP00000219700                   Tax_Id = 9606                   Heme oxygenase 2               YNGLIHRK   SWISS-PROT: P46779   IPI00008411.2   P46779       (SEQ ID NO: 282)   ENSEMBL: ENSP00000311213                   Tax_Id = 9606                   60S ribosomal protein                   L28 60S ribosomal                   protein L28               YQLSSEAAK   SWISS-PROT: Q9NRW7   IPI00090327.1   Q9NRW7       (SEQ ID NO: 283)   REFSEQ_NP: NP_009190                   ENSEMBL: ENSP00000259149                   Tax_Id = 9606                   Vacuolar protein sorting-                   associated protein 45               YSALNVQHQMLK   REFSEQ_NP: NP_055313   IPI00004962.1           (SEQ ID NO: 284)   TREMBL: O00461                   ENSEMBL: ENSP00000309893                   Tax_Id = 9606                   130 kDa golgi-localized                   phosphoprotein               YSQVLANGLDNK   SWISS-PROT: P25232   IPI00013296.1   P25232       (SEQ ID NO: 285)   REFSEQ_NP: NP_072045                   ENSEMBL: ENSP00000211372;                   ENSP00000313640                   Tax_Id = 9606 40S                   ribosomal protein S18               YYPTEDVPRK   SWISS-PROT: Q02878   IPI00027271.1   Q02878       (SEQ ID NO: 286)   REFSEQ_NP: NP_000961                   TREMBL: Q8N5Z7; Q9HBB3;                   Q8TBK5; Q8WW97                   ENSEMBL: ENSP00000202773                   Tax_Id = 9606                   60S ribosomal protein                   L6               Cells were treated with 0.35 μM compound 1 for 6, 36 and 72 hours before harvest and subject to LC/MS based protein profiling.       There are biological duplicates and technique duplicates.       A two-way ANOVA mixed model was utilized to identify drug treatment effect as well as treatment and time interaction on the expression of peptide ions.       The peptide ions identified as modulated by the drug are those with p value &lt; 0.05 in either the Treatment effect or Treatment × Time interaction.       FDR correction was not applied to the protein profiling data.            
Remarkably, these genes are mainly involved in apoptosis (AIFM1, ACIN1, BIRC2, BIRC5, BAD, BAG3, BAX, CARD10, CIAPIN1, DAP, DAXX, DAPK1, PDCD11 and PDCD4), cell growth and proliferation (Ki67, BOP1, GAS1 and ING3), cell cycles (cyclin family members of B, D, E, G, H, I, K, L; CDK 2 and 7; centromere protein A, B, M, N; CDKN3 and CDKN1B) and multiple tyrosine kinases such as ERBB3, PDGFR, FGFR1, 2 and 4, MET, EPH as well as the down-stream IGF1R signaling pathways: MAPK, PI3K and AKT. Interestingly, contrary to what was reported with IGF1R antibody (R. Baserga, Expert Opin. Ther. Targets; 9:753-68 (2005)), inhibition of kinase activity by compound 1 did not result in the receptor down-regulation, but rather induced the expression of IGF1R, insulin receptor substrate 2 (IRS2) and insulin-like growth factor binding protein 3 (IGFBP3). This could be one of the mechanisms by which cells attempt to compensate the reduced activity of the IGF1R caused by the inhibitor, and the feedback loop then restores the inhibited pathway activity.
 
Genes Related to Acquired Resistance to IGF1R Inhibitor Compound 1:
 
     Acquired resistance to anti-cancer agents is a major clinical problem. To study the mechanism of acquired resistance to IGF1R inhibitor, we derived resistance cells by culturing a compound 1 sensitive RMS cell line RD-1(IC 50 =0.238 μM) in the presence of a gradually increased concentration of compound 1 in every other passage to reach the resistance level of plateau. The resulted resistant RD1 cells had IC 50 =1.999 μM to compound 1, which is 8 fold higher than the IC 50  of the parent RD1. In order to identify markers that may contribute to acquired resistance to the IGF1R inhibitor, global gene expression profiles for both parental RD1 and resistant RD1 were analyzed using Affymetrix gene chip. A statistical analysis was conducted using GeneChip® Expression Analysis software MAS 5.0 to identify the genes differentially expressed between the sensitive and acquired resistant cells (Table 8). 
                                                                       TABLE 8               Genes related to acquired resistance to compound 1.                   Genes higher expressed in acquired resistant RD-1 cells            209278_s_at   L27624   tissue factor pathway inhibitor 2   TFPI2   194       202820_at   NM_001621   aryl hydrocarbon receptor   AHR   157.6       216598_s_at   S69738   chemokine (C-C motif) ligand 2   CCL2   104       209875_s_at   M83248   secreted phosphoprotein 1 (osteopontin,   SPP1   104               bone sialoprotein I, early T-lymphocyte               activation 1)       201301_s_at   BC000182   annexin A4   ANXA4   97       206785_s_at   NM_002260   killer cell lectin-like receptor subfamily   KLRC1 /// KLRC2   84.4               C, member 1 /// killer cell lectin-like               receptor subfamily C, member 2       201427_s_at   NM_005410   selenoprotein P, plasma, 1   SEPP1   84.4       213156_at   BG251521     Homo sapiens , clone IMAGE: 4214654,   —   64               mRNA       201005_at   NM_001769   CD9 molecule   CD9   59.7       220038_at   NM_013257   serum/glucocorticoid regulated kinase   SGK3   48.5               family, member 3       212681_at   AI770004   erythrocyte membrane protein band   EPB41L3   45.3               4.1-like 3       220014_at   NM_016644   proline rich 16   PRR16   45.3       205563_at   NM_002256   KiSS-1 metastasis-suppressor   KISS1   42.2       211343_s_at   M33653   collagen, type XIII, alpha 1   COL13A1   34.3       202555_s_at   NM_005965   myosin, light chain kinase /// myosin,   MYLK   32               light chain kinase       212909_at   AL567376   LY6/PLAUR domain containing 1   LYPD1   29.9       206363_at   NM_005360   v-maf musculoaponeurotic   MAF   29.9               fibrosarcoma oncogene homolog               (avian)       217967_s_at   AF288391   family with sequence similarity 129,   FAM129A   27.9               member A       209789_at   BF939649   coronin, actin binding protein, 2B   CORO2B   26       206693_at   NM_000880   interleukin 7   IL7   26       206157_at   NM_002852   pentraxin-related gene, rapidly induced   PTX3   26               by IL-1 beta       206315_at   NM_004750   cytokine receptor-like factor 1   CRLF1   24.3       222020_s_at   AW117456   neurotrimin   HNT   24.3       221884_at   BE466525   ecotropic viral integration site 1   EVI1   22.6       205691_at   NM_004209   synaptogyrin 3   SYNGR3   22.6       203888_at   NM_000361   thrombomodulin   THBD   21.1       214841_at   AF070524   cornichon homolog 3 ( Drosophila )   CNIH3   17.1       210809_s_at   D13665   periostin, osteoblast specific factor   POSTN   17.1       203910_at   NM_004815   Rho GTPase activating protein 29   ARHGAP29   16       214587_at   BE877796   collagen, type VIII, alpha 1   COL8A1   14.9       214297_at   BE857703   Chondroitin sulfate proteoglycan 4   CSPG4   14.9               (melanoma-associated)       204014_at   NM_001394   dual specificity phosphatase 4   DUSP4   14.9       201163_s_at   NM_001553   insulin-like growth factor binding   IGFBP7   14.9               protein 7       221986_s_at   AW006750   kelch-like 24 ( Drosophila )   KLHL24   14.9       204249_s_at   NM_005574   LIM domain only 2 (rhombotin-like 1)   LMO2   14.9       217901_at   BF031829   Desmoglein 2   DSG2   13.9       204836_at   NM_000170   glycine dehydrogenase   GLDC   13.9               (decarboxylating)       204475_at   NM_002421   matrix metallopeptidase 1 (interstitial   MMP1   13.9               collagenase)       205858_at   NM_002507   nerve growth factor receptor (TNFR   NGFR   13.9               superfamily, member 16)       213716_s_at   BF939675   secreted and transmembrane 1   SECTM1   13.9       214954_at   BF977837   sushi domain containing 5   SUSD5   13.9       205110_s_at   NM_004114   fibroblast growth factor 13   FGF13   13       207018_s_at   NM_004163   RAB27B, member RAS oncogene   RAB27B ///   13               family /// SH3 domain binding glutamic   SH3BGR               acid-rich protein       212912_at   AI992251   ribosomal protein S6 kinase, 90 kDa,   RPS6KA2   13               polypeptide 2       205862_at   NM_014668   GREB1 protein   GREB1   12.1       209870_s_at   AW571582   amyloid beta (A4) precursor protein-   APBA2   11.3               binding, family A, member 2 (X11-like)       212062_at   AB014511   ATPase, Class II, type 9A   ATP9A   11.3       213865_at   AI378788   discoidin, CUB and LCCL domain   DCBLD2   11.3               containing 2       205884_at   NM_000885   integrin, alpha 4 (antigen CD49D, alpha   ITGA4   11.3               4 subunit of VLA-4 receptor)       212188_at   AA551075   potassium channel tetramerisation   KCTD12   11.3               domain containing 12 /// potassium               channel tetramerisation domain               containing 12       202625_at   AI356412   v-yes-1 Yamaguchi sarcoma viral   LYN   11.3               related oncogene homolog /// v-yes-1               Yamaguchi sarcoma viral related               oncogene homolog       205538_at   NM_003389   coronin, actin binding protein, 2A   CORO2A   10.6       206638_at   NM_000867   5-hydroxytryptamine (serotonin)   HTR2B   10.6               receptor 2B       202718_at   NM_000597   insulin-like growth factor binding   IGFBP2   10.6               protein 2, 36 kDa       219181_at   NM_006033   lipase, endothelial   LIPG   10.6       209610_s_at   BF340083   solute carrier family 1   SLC1A4   10.6               (glutamate/neutral amino acid               transporter), member 4       214930_at   AW449813   SLIT and NTRK-like family, member 5   SLITRK5   10.6       210095_s_at   M31159   insulin-like growth factor binding   IGFBP3   9.8               protein 3       209598_at   AB020690   paraneoplastic antigen MA2   PNMA2   9.8       209859_at   AF220036   tripartite motif-containing 9   TRIM9   9.8       213712_at   BF508639   elongation of very long chain fatty   ELOVL2   9.2               acids (FEN1/Elo2, SUR4/Elo3, yeast)-               like 2       219093_at   NM_017933   hypothetical protein FLJ20701 ///   FLJ20701   8               hypothetical protein FLJ20701       202350_s_at   NM_002380   matrilin 2   MATN2   8       204048_s_at   AA551142   phosphatase and actin regulator 2   PHACTR2   8       206893_at   NM_002968   sal-like 1 ( Drosophila )   SALL1   8       209591_s_at   M60316   bone morphogenetic protein 7   BMP7   7.5               (osteogenic protein 1)       209167_at   AI419030   glycoprotein M6B   GPM6B   7.5       211959_at   AW007532   insulin-like growth factor binding   IGFBP5   7.5               protein 5       205825_at   NM_000439   proprotein convertase subtilisin/kexin   PCSK1   7.5               type 1       215856_at   AK025833   CD33 molecule-like 3   CD33L3   7       205816_at   NM_002214   integrin, beta 8   ITGB8   7       212092_at   BE858180   paternally expressed 10   PEG10   7       207426_s_at   NM_003326   tumor necrosis factor (ligand)   TNFSF4   7               superfamily, member 4 (tax-               transcriptionally activated glycoprotein               1, 34 kDa)       203940_s_at   NM_014909   vasohibin 1   VASH1   7       221019_s_at   NM_030781   collectin sub-family member 12 ///   COLEC12   6.5               collectin sub-family member 12       206669_at   NM_013445   glutamate decarboxylase 1 (brain,   GAD1 /// LASS6   6.5               67 kDa) /// LAG1 homolog, ceramide               synthase 6 ( S. cerevisiae )       202755_s_at   AI354864   glypican 1   GPC1   6.5       212314_at   AB018289   KIAA0746 protein   KIAA0746   6.5       215446_s_at   L16895   lysyl oxidase   LOX   6.5       202729_s_at   NM_000627   latent transforming growth factor beta   LTBP1   6.5               binding protein 1       207808_s_at   NM_000313   protein S (alpha)   PROS1   6.5       204198_s_at   AA541630   runt-related transcription factor 3   RUNX3   6.5       212812_at   AI700633   Serine incorporator 5   SERINC5   6.5       202935_s_at   AI382146   SRY (sex determining region Y)-box 9   SOX9   6.5               (campomelic dysplasia, autosomal sex-               reversal)       201925_s_at   NM_000574   CD55 molecule, decay accelerating   CD55   6.1               factor for complement (Cromer blood               group)       221760_at   BG287153   Mannosidase, alpha, class 1A, member 1   MAN1A1   6.1       211026_s_at   BC006230   monoglyceride lipase /// monoglyceride   MGLL   6.1               lipase       213906_at   AW592266   v-myb myeloblastosis viral oncogene   MYBL1   6.1               homolog (avian)-like 1       201110_s_at   NM_003246   thrombospondin 1   THBS1   6.1       215034_s_at   AI189753   transmembrane 4 L six family member 1   TM4SF1   6.1       44790_s_at   AI129310   chromosome 13 open reading frame 18   C13orf18   5.7       219619_at   NM_017594   DIRAS family, GTP-binding RAS-like 2   DIRAS2   5.7       202149_at   AL136139   neural precursor cell expressed,   NEDD9   5.7               developmentally down-regulated 9       204671_s_at   BE677131   ankyrin repeat domain 6   ANKRD6   5.3       204456_s_at   AW611727   growth arrest-specific 1   GAS1   5.3       209631_s_at   U87460   G protein-coupled receptor 37   GPR37   5.3               (endothelin receptor type B-like)       213954_at   AB020695   KIAA0888 protein   KIAA0888   5.3       212298_at   BE620457   neuropilin 1   NRP1   5.3       205593_s_at   NM_002606   phosphodiesterase 9A   PDE9A   5.3       204908_s_at   NM_005178   B-cell CLL/lymphoma 3   BCL3   4.9       206932_at   NM_003956   cholesterol 25-hydroxylase   CH25H   4.9       218031_s_at   NM_018589   checkpoint suppressor 1   CHES1   4.9       204072_s_at   NM_023037   furry homolog ( Drosophila )   FRY   4.9       39549_at   AI743090   neuronal PAS domain protein 2   NPAS2   4.9       218736_s_at   NM_017734   palmdelphin   PALMD   4.9       203708_at   NM_002600   phosphodiesterase 4B, cAMP-specific   PDE4B   4.9               (phosphodiesterase E4 dunce homolog,                 Drosophila )       214660_at   X68742   Pelota homolog ( Drosophila )   PELO   4.9       221524_s_at   AF272036   Ras-related GTP binding D   RRAGD   4.9       208608_s_at   NM_021021   syntrophin, beta 1 (dystrophin-   SNTB1   4.9               associated protein A1, 59 kDa, basic               component 1)       203476_at   NM_006670   trophoblast glycoprotein   TPBG   4.9       221156_x_at   NM_004748   cell cycle progression 1   CCPG1   4.6       213230_at   AI422335   cerebellar degeneration-related protein   CDR2L   4.6               2-like       205100_at   NM_005110   glutamine-fructose-6-phosphate   GFPT2   4.6               transaminase 2       201141_at   NM_002510   glycoprotein (transmembrane) nmb   GPNMB   4.6       201656_at   NM_000210   integrin, alpha 6   ITGA6   4.6       221584_s_at   U11058   potassium large conductance calcium-   KCNMA1   4.6               activated channel, subfamily M, alpha               member 1       212190_at   AL541302   serpin peptidase inhibitor, clade E   SERPINE2   4.6               (nexin, plasminogen activator inhibitor               type 1), member 2       201147_s_at   BF347089   TIMP metallopeptidase inhibitor 3   TIMP3   4.6               (Sorsby fundus dystrophy,               pseudoinflammatory)       213943_at   X99268   twist homolog 1   TWIST1   4.6               (acrocephalosyndactyly 3; Saethre-               Chotzen syndrome) ( Drosophila )       221973_at   AI983904   CDNA clone IMAGE: 5217021, with   —   4.3               apparent retained intron       220658_s_at   NM_020183   aryl hydrocarbon receptor nuclear   ARNTL2   4.3               translocator-like 2       212992_at   AI935123   chromosome 14 open reading frame 78   C14orf78   4.3       205379_at   NM_001236   carbonyl reductase 3   CBR3   4.3       203139_at   NM_004938   death-associated protein kinase 1   DAPK1   4.3       212641_at   AL023584   human immunodeficiency virus type I   HIVEP2   4.3               enhancer binding protein 2       205559_s_at   NM_006200   proprotein convertase subtilisin/kexin   PCSK5   4.3               type 5       212646_at   D42043   raftlin, lipid raft linker 1   RFTN1   4.3       205383_s_at   NM_015642   zinc finger and BTB domain containing   ZBTB20   4.3               20       205390_s_at   NM_000037   ankyrin 1, erythrocytic /// ankyrin 1,   ANK1   4               erythrocytic       202888_s_at   NM_001150   alanyl (membrane) aminopeptidase   ANPEP   4               (aminopeptidase N, aminopeptidase M,               microsomal aminopeptidase, CD13,               p150)       209962_at   M34986   erythropoietin receptor   EPOR   4       221245_s_at   NM_030804   frizzled homolog 5 ( Drosophila ) ///   FZD5   4               frizzled homolog 5 ( Drosophila )       201125_s_at   NM_002213   integrin, beta 5   ITGB5   4       211470_s_at   AF186255   sulfotransferase family, cytosolic, 1C,   SULT1C1   4               member 1       210512_s_at   AF022375   vascular endothelial growth factor A   VEGFA   4       202222_s_at   NM_001927   desmin   DES   3.7       205366_s_at   NM_018952   homeobox B6   HOXB6   3.7       213424_at   AB020702   KIAA0895 protein   KIAA0895   3.7       209888_s_at   M20643   myosin, light chain 1, alkali; skeletal,   MYL1   3.7               fast       218162_at   NM_020190   olfactomedin-like 3   OLFML3   3.7       202074_s_at   NM_021980   optineurin   OPTN   3.7       219304_s_at   NM_025208   platelet derived growth factor D   PDGFD   3.7       201739_at   NM_005627   serum/glucocorticoid regulated kinase   SGK   3.7       205856_at   NM_015865   solute carrier family 14 (urea   SLC14A1   3.7               transporter), member 1 (Kidd blood               group)       202363_at   AF231124   sparc/osteonectin, cwcv and kazal-like   SPOCK1   3.7               domains proteoglycan (testican) 1       204236_at   NM_002017   Friend leukemia virus integration 1   FLI1   3.5       202794_at   NM_002194   inositol polyphosphate-1-phosphatase   INPP1   3.5       205876_at   NM_002310   leukemia inhibitory factor receptor   LIFR   3.5               alpha       202161_at   NM_002741   protein kinase N1   PKN1   3.5       218640_s_at   NM_024613   pleckstrin homology domain   PLEKHF2   3.5               containing, family F (with FYVE               domain) member 2       203680_at   NM_002736   protein kinase, cAMP-dependent,   PRKAR2B   3.5               regulatory, type II, beta       204897_at   AA897516   prostaglandin E receptor 4 (subtype   PTGER4   3.5               EP4)       213325_at   AA129716   poliovirus receptor-related 3   PVRL3   3.5       203217_s_at   NM_003896   ST3 beta-galactoside alpha-2,3-   ST3GAL5   3.5               sialyltransferase 5       215440_s_at   AL523320   brain expressed X-linked-like 1   BEXL1   3.2       209081_s_at   NM_030582   collagen, type XVIII, alpha 1   COL18A1   3.2       204036_at   AW269335   endothelial differentiation,   EDG2   3.2               lysophosphatidic acid G-protein-               coupled receptor, 2       200878_at   AF052094   endothelial PAS domain protein 1   EPAS1   3.2       213526_s_at   BF215644   protein F25965   F25965   3.2       201631_s_at   NM_003897   immediate early response 3   IER3   3.2       203474_at   NM_006633   IQ motif containing GTPase activating   IQGAP2   3.2               protein 2       201015_s_at   NM_021991   junction plakoglobin   JUP   3.2       203939_at   NM_002526   5′-nucleotidase, ecto (CD73)   NT5E   3.2       213075_at   AL050002   olfactomedin-like 2A   OLFML2A   3.2       205226_at   NM_006207   platelet-derived growth factor receptor-   PDGFRL   3.2               like       200986_at   NM_000062   serpin peptidase inhibitor, clade G (C1   SERPING1   3.2               inhibitor), member 1, (angioedema,               hereditary)       203167_at   NM_003255   TIMP metallopeptidase inhibitor 2   TIMP2   3.2       215783_s_at   X14174   alkaline phosphatase, liver/bone/kidney   ALPL   3       213004_at   AI074333   angiopoietin-like 2   ANGPTL2   3       212614_at   BG285011   AT rich interactive domain 5B (MRF1-   ARID5B   3               like)       221211_s_at   NM_020152   chromosome 21 open reading frame 7   C21orf7   3       209906_at   U62027   complement component 3a receptor 1   C3AR1   3       210026_s_at   AY028896   caspase recruitment domain family,   CARD10   3               member 10       201360_at   NM_000099   cystatin C (amyloid angiopathy and   CST3   3               cerebral hemorrhage)       217889_s_at   NM_024843   cytochrome b reductase 1   CYBRD1   3       203791_at   NM_005509   Dmx-like 1   DMXL1   3       202500_at   NM_006736   DnaJ (Hsp40) homolog, subfamily B,   DNAJB2   3               member 2       209343_at   BC002449   EF-hand domain family, member D1   EFHD1   3       206307_s_at   NM_004472   forkhead box D1   FOXD1   3       216033_s_at   S74774   FYN oncogene related to SRC, FGR,   FYN   3               YES       204115_at   NM_004126   guanine nucleotide binding protein (G   GNG11   3               protein), gamma 11       214104_at   AI703188   G protein-coupled receptor 161   GPR161   3       203108_at   NM_003979   G protein-coupled receptor, family C,   GPRC5A   3               group 5, member A       218469_at   NM_013372   gremlin 1, cysteine knot superfamily,   GREM1   3               homolog ( Xenopus laevis )       215933_s_at   Z21533   homeobox, hematopoietically expressed   HHEX   3       209185_s_at   AF073310   insulin receptor substrate 2   IRS2   3       221011_s_at   NM_030915   limb bud and heart development   LBH   3               homolog (mouse) /// limb bud and heart               development homolog (mouse)       201069_at   NM_004530   matrix metallopeptidase 2 (gelatinase   MMP2   3               A, 72 kDa gelatinase, 72 kDa type IV               collagenase)       212096_s_at   AL096842   mitochondrial tumor suppressor 1   MTUS1   3       205880_at   NM_002742   protein kinase D1   PRKD1   3       217983_s_at   NM_003730   ribonuclease T2   RNASET2   3       202636_at   NM_005667   ring finger protein 103   RNF103   3       201286_at   Z48199   syndecan 1   SDC1   3       216997_x_at   AL358975   transducin-like enhancer of split 4   TLE4   3               (E(sp1) homolog,  Drosophila )       213338_at   BF062629   transmembrane protein 158   TMEM158   3       219296_at   NM_019028   zinc finger, DHHC-type containing 13   ZDHHC13   3       209765_at   Y13786   ADAM metallopeptidase domain 19   ADAM19   2.8               (meltrin beta)       212560_at   AV728268   chromosome 11 open reading frame 32   C11orf32   2.8       218546_at   NM_024709   chromosome 1 open reading frame 115   C1orf115   2.8       213492_at   X06268   collagen, type II, alpha 1 (primary   COL2A1   2.8               osteoarthritis, spondyloepiphyseal               dysplasia, congenital)       218995_s_at   NM_001955   endothelin 1   EDN1   2.8       201809_s_at   NM_000118   endoglin (Osler-Rendu-Weber   ENG   2.8               syndrome 1)       219683_at   NM_017412   frizzled homolog 3 ( Drosophila )   FZD3   2.8       205462_s_at   NM_002149   hippocalcin-like 1   HPCAL1   2.8       212830_at   W68084   multiple EGF-like-domains 9   MEGF9   2.8       205054_at   NM_004543   nebulin   NEB   2.8       209324_s_at   BF304996   regulator of G-protein signalling 16   RGS16   2.8       210365_at   D43967   runt-related transcription factor 1 (acute   RUNX1   2.8               myeloid leukemia 1; aml1 oncogene)       207413_s_at   NM_000335   sodium channel, voltage-gated, type V,   SCN5A   2.8               alpha (long QT syndrome 3)       201920_at   NM_005415   solute carrier family 20 (phosphate   SLC20A1   2.8               transporter), member 1       204981_at   NM_002555   solute carrier family 22 (organic cation   SLC22A18   2.8               transporter), member 18       204466_s_at   BG260394   synuclein, alpha (non A4 component of   SNCA   2.8               amyloid precursor) /// synuclein, alpha               (non A4 component of amyloid               precursor)       206258_at   NM_013305   ST8 alpha-N-acetyl-neuraminide alpha-   ST8SIA5   2.8               2,8-sialyltransferase 5       218424_s_at   NM_018234   STEAP family member 3   STEAP3   2.8       214378_at   BF109662   tissue factor pathway inhibitor   TFPI   2.8               (lipoprotein-associated coagulation               inhibitor)       212665_at   AL556438   TCDD-inducible poly(ADP-ribose)   TIPARP   2.8               polymerase       219736_at   NM_018700   tripartite motif-containing 36   TRIM36   2.8       217823_s_at   AL562528   ubiquitin-conjugating enzyme E2, J1   UBE2J1   2.8               (UBC6 homolog, yeast)       213429_at   AW025579   CDNA FLJ26539 fis, clone KDN09310   —   2.6       215617_at   AU145711   CDNA FLJ11754 fis, clone   —   2.6               HEMBA1005588       60474_at   AA469071   chromosome 20 open reading frame 42   C20orf42   2.6       202403_s_at   AA788711   collagen, type I, alpha 2   COL1A2   2.6       201200_at   NM_003851   cellular repressor of E1A-stimulated   CREG1   2.6               genes 1       202481_at   NM_004753   dehydrogenase/reductase (SDR family)   DHRS3   2.6               member 3       218532_s_at   NM_019000   hypothetical protein FLJ20152   FLJ20152   2.6       210220_at   L37882   frizzled homolog 2 ( Drosophila )   FZD2   2.6       204137_at   NM_003272   G protein-coupled receptor 137B   GPR137B   2.6       205240_at   NM_013296   G-protein signalling modulator 2   GPSM2   2.6               (AGS3-like,  C. elegans )       212942_s_at   AB033025   KIAA1199   KIAA1199   2.6       220940_at   NM_025190   KIAA1641   KIAA1641   2.6       213248_at   AL577024   hypothetical protein LOC221362 ///   LOC221362 ///   2.6               similar to heterogeneous nuclear   LOC730101               ribonucleoprotein A/B       40016_g_at   AB002301   microtubule associated serine/threonine   MAST4   2.6               kinase family member 4       208047_s_at   NM_005966   NGFI-A binding protein 1 (EGR1   NAB1   2.6               binding protein 1)       217765_at   NM_013392   nuclear receptor binding protein 1   NRBP1   2.6       209034_at   AF279899   proline-rich nuclear receptor   PNRC1   2.6               coactivator 1       209282_at   AF309082   protein kinase D2   PRKD2   2.6       201481_s_at   NM_002862   phosphorylase, glycogen; brain   PYGB   2.6       219610_at   NM_022448   Rho-guanine nucleotide exchange   RGNEF   2.6               factor       219457_s_at   NM_024832   Ras and Rab interactor 3   RIN3   2.6       206558_at   NM_005069   single-minded homolog 2 ( Drosophila )   SIM2   2.6       215223_s_at   W46388   superoxide dismutase 2, mitochondrial   SOD2   2.6       204955_at   NM_006307   sushi-repeat-containing protein, X-   SRPX   2.6               linked       210612_s_at   AF318616   synaptojanin 2   SYNJ2   2.6       209198_s_at   BC004291   synaptotagmin XI   SYT11   2.6       205122_at   BF439316   transmembrane protein with EGF-like   TMEFF1   2.6               and two follistatin-like domains 1       201690_s_at   AA524023   tumor protein D52   TPD52   2.6       202893_at   NM_006377   unc-13 homolog B ( C. elegans )   UNC13B   2.6       204254_s_at   NM_000376   vitamin D (1,25-dihydroxyvitamin D3)   VDR   2.6               receptor       208622_s_at   AA670344   villin 2 (ezrin)   VIL2   2.6       212993_at   AA114166   MRNA; cDNA DKFZp667B1718   —   2.5               (from clone DKFZp667B1718)       221881_s_at   AI638420   adducin 3 (gamma) /// chloride   ADD3 /// CLIC4   2.5               intracellular channel 4       220092_s_at   NM_018153   anthrax toxin receptor 1   ANTXR1   2.5       40148_at   U62325   amyloid beta (A4) precursor protein-   APBB2   2.5               binding, family B, member 2 (Fe65-               like)       203576_at   NM_001190   branched chain aminotransferase 2,   BCAT2   2.5               mitochondrial       215509_s_at   AL137654   BUB1 budding uninhibited by   BUB1   2.5               benzimidazoles 1 homolog (yeast)       220975_s_at   NM_030968   C1q and tumor necrosis factor related   C1QTNF1   2.5               protein 1 /// C1q and tumor necrosis               factor related protein 1       220918_at   NM_025143   chromosome 21 open reading frame 96   C21orf96   2.5       208908_s_at   AF327443   calpastatin   CAST   2.5       204154_at   NM_001801   cysteine dioxygenase, type I   CDO1   2.5       212091_s_at   AI141603   collagen, type VI, alpha 1   COL6A1   2.5       202517_at   NM_001313   collapsin response mediator protein 1   CRMP1   2.5       201487_at   NM_001814   cathepsin C   CTSC   2.5       201279_s_at   BC003064   disabled homolog 2, mitogen-   DAB2   2.5               responsive phosphoprotein               ( Drosophila )       222101_s_at   BF222893   dachsous 1 ( Drosophila )   DCHS1   2.5       202929_s_at   NM_001355   D-dopachrome tautomerase   DDT   2.5       203881_s_at   NM_004010   dystrophin (muscular dystrophy,   DMD   2.5               Duchenne and Becker types)       218225_at   NM_016581   ECSIT homolog ( Drosophila )   ECSIT   2.5       217154_s_at   AL035250   endothelin 3   EDN3   2.5       205738_s_at   NM_004102   fatty acid binding protein 3, muscle and   FABP3   2.5               heart (mammary-derived growth               inhibitor)       201910_at   BF213279   FERM, RhoGEF (ARHGEF) and   FARP1   2.5               pleckstrin domain protein 1               (chondrocyte-derived)       207357_s_at   NM_017540   UDP-N-acetyl-alpha-D-   GALNT10   2.5               galactosamine:polypeptide N-               acetylgalactosaminyltransferase 10               (GalNAc-T10)       216733_s_at   X86401   glycine amidinotransferase (L-   GATM   2.5               arginine:glycine amidinotransferase)       221577_x_at   AF003934   growth differentiation factor 15   GDF15   2.5       203390_s_at   NM_002254   kinesin family member 3C   KIF3C   2.5       203130_s_at   NM_004522   kinesin family member 5C   KIF5C   2.5       204682_at   NM_000428   latent transforming growth factor beta   LTBP2   2.5               binding protein 2       219278_at   NM_004672   mitogen-activated protein kinase kinase   MAP3K6   2.5               kinase 6       206571_s_at   NM_004834   mitogen-activated protein kinase kinase   MAP4K4   2.5               kinase kinase 4       218890_x_at   NM_016622   mitochondrial ribosomal protein L35   MRPL35   2.5       212365_at   BF215996   myosin IB   MYO1B   2.5       215073_s_at   AL554245   nuclear receptor subfamily 2, group F,   NR2F2   2.5               member 2       204622_x_at   NM_006186   nuclear receptor subfamily 4, group A,   NR4A2   2.5               member 2       210448_s_at   U49396   purinergic receptor P2X, ligand-gated   P2RX5   2.5               ion channel, 5       210139_s_at   L03203   peripheral myelin protein 22   PMP22   2.5       209158_s_at   BC004361   pleckstrin homology, Sec7 and coiled-   PSCD2   2.5               coil domains 2 (cytohesin-2)       49306_at   AI890191   Ras association (RalGDS/AF-6)   RASSF4   2.5               domain family 4       204364_s_at   BE535746   receptor accessory protein 1   REEP1   2.5       209568_s_at   AF186779   ral guanine nucleotide dissociation   RGL1   2.5               stimulator-like 1       209306_s_at   AI139569   SWAP-70 protein   SWAP70   2.5       209890_at   AF065389   tetraspanin 5 /// tetraspanin 5   TSPAN5   2.5       213996_at   NM_013313   yippee-like 1 ( Drosophila )   YPEL1   2.5       217783_s_at   NM_016061   yippee-like 5 ( Drosophila )   YPEL5   2.5       212985_at   BF115739   Full-length cDNA clone   —   2.3               CS0DC015YK09 of Neuroblastoma               Cot 25-normalized of  Homo sapiens                 (human)       218795_at   NM_016361   acid phosphatase 6, lysophosphatidic   ACP6   2.3       205401_at   NM_003659   alkylglycerone phosphate synthase   AGPS   2.3       202587_s_at   BC001116   adenylate kinase 1   AK1   2.3       202920_at   BF726212   ankyrin 2, neuronal   ANK2   2.3       210202_s_at   U87558   bridging integrator 1   BIN1   2.3       200921_s_at   NM_001731   B-cell translocation gene 1, anti-   BTG1   2.3               proliferative       205308_at   NM_016010   chromosome 8 open reading frame 70   C8orf70   2.3       200622_x_at   AV685208   calmodulin 3 (phosphorylase kinase,   CALM3   2.3               delta)       201850_at   NM_001747   capping protein (actin filament),   CAPG   2.3               gelsolin-like       220004_at   NM_018665   DEAD (Asp-Glu-Ala-Asp) box   DDX43   2.3               polypeptide 43       215482_s_at   AJ011307   eukaryotic translation initiation factor   EIF2B4   2.3               2B, subunit 4 delta, 67 kDa       219253_at   NM_024121   family with sequence similarity 11,   FAM11B   2.3               member B       209576_at   AL049933   guanine nucleotide binding protein (G   GNAI1   2.3               protein), alpha inhibiting activity               polypeptide 1       221902_at   AL567940   G protein-coupled receptor 153   GPR153   2.3       218603_at   NM_016217   headcase homolog ( Drosophila )   HECA   2.3       221004_s_at   NM_030926   integral membrane protein 2C ///   ITM2C   2.3               integral membrane protein 2C       212492_s_at   AW237172   jumonji domain containing 2B   JMJD2B   2.3       219287_at   NM_014505   potassium large conductance calcium-   KCNMB4   2.3               activated channel, subfamily M, beta               member 4       204334_at   AA488672   Kruppel-like factor 7 (ubiquitous)   KLF7   2.3       204584_at   AI653981   L1 cell adhesion molecule   L1CAM   2.3       203041_s_at   J04183   lysosomal-associated membrane protein 2   LAMP2   2.3       208949_s_at   BC001120   lectin, galactoside-binding, soluble, 3   LGALS3   2.3               (galectin 3)       204091_at   NM_002601   phosphodiesterase 6D, cGMP-specific,   PDE6D   2.3               rod, delta       211924_s_at   AY029180   plasminogen activator, urokinase   PLAUR   2.3               receptor /// plasminogen activator,               urokinase receptor       206574_s_at   NM_007079   protein tyrosine phosphatase type IVA,   PTP4A3   2.3               member 3       207836_s_at   NM_006867   RNA binding protein with multiple   RBPMS   2.3               splicing       202898_at   NM_014654   syndecan 3 (N-syndecan)   SDC3   2.3       208127_s_at   NM_014011   suppressor of cytokine signaling 5   SOCS5   2.3       212780_at   AA700167   son of sevenless homolog 1   SOS1   2.3               ( Drosophila )       216941_s_at   AK026521   TATA box binding protein (TBP)-   TAF1B   2.3               associated factor, RNA polymerase I,               B, 63 kDa       203083_at   NM_003247   thrombospondin 2   THBS2   2.3       212989_at   AI377497   transmembrane protein 23   TMEM23   2.3       211300_s_at   K03199   tumor protein p53 (Li-Fraumeni   TP53   2.3               syndrome)       210609_s_at   BC000474   tumor protein p53 inducible protein 3   TP53I3   2.3       202368_s_at   AI986461   translocation associated membrane   TRAM2   2.3               protein 2       202478_at   NM_021643   tribbles homolog 2 ( Drosophila )   TRIB2   2.3       214023_x_at   AL533838   tubulin, beta 2B   TUBB2B   2.3       208998_at   U94592   uncoupling protein 2 (mitochondrial,   UCP2   2.3               proton carrier)       218807_at   NM_006113   vav 3 oncogene   VAV3   2.3       203855_at   NM_014969   WD repeat domain 47   WDR47   2.3       221646_s_at   AF267859   zinc finger, DHHC-type containing 11   ZDHHC11   2.3       215447_at   AL080215   —   —   2.1       205434_s_at   AW451954   AP2 associated kinase 1 /// hypothetical   AAK1 ///   2.1               protein LOC647217   LOC647217       210517_s_at   AB003476   A kinase (PRKA) anchor protein   AKAP12   2.1               (gravin) 12       214073_at   BG475299   Aldehyde dehydrogenase 1 family,   ALDH1A3   2.1               member A3       219637_at   NM_025139   armadillo repeat containing 9   ARMC9   2.1       200070_at   BC001393   chromosome 2 open reading frame 24   C2orf24   2.1               /// chromosome 2 open reading frame               24       209829_at   AB002384   chromosome 6 open reading frame 32   C6orf32   2.1       204392_at   NM_003656   calcium/calmodulin-dependent protein   CAMK1   2.1               kinase I       209956_s_at   U23460   calcium/calmodulin-dependent protein   CAMK2B   2.1               kinase (CaM kinase) II beta       218309_at   NM_018584   calcium/calmodulin-dependent protein   CAMK2N1   2.1               kinase II inhibitor 1       212624_s_at   BF339445   chimerin (chimaerin) 1   CHN1   2.1       206414_s_at   NM_003887   development and differentiation   DDEF2   2.1               enhancing factor 2       212503_s_at   N22859   DIP2 disco-interacting protein 2   DIP2C   2.1               homolog C ( Drosophila )       202196_s_at   NM_013253   dickkopf homolog 3 ( Xenopus laevis )   DKK3   2.1       209365_s_at   U65932   extracellular matrix protein 1   ECM1   2.1       220161_s_at   NM_019114   erythrocyte membrane protein band 4.1   EPB41L4B   2.1               like 4B       221766_s_at   AW246673   family with sequence similarity 46,   FAM46A   2.1               member A       202949_s_at   NM_001450   four and a half LIM domains 2   FHL2   2.1       218610_s_at   NM_018340   hypothetical protein FLJ11151   FLJ11151   2.1       218880_at   N36408   FOS-like antigen 2   FOSL2   2.1       219170_at   NM_024333   fibronectin type III and SPRY domain   FSD1 ///   2.1               containing 1 /// similar to fibronectin   LOC731565               type III and SPRY domain containing 1       218204_s_at   NM_024513   FYVE and coiled-coil domain   FYCO1   2.1               containing 1       218070_s_at   NM_013335   GDP-mannose pyrophosphorylase A   GMPPA   2.1       214438_at   M60721   H2.0-like homeobox 1 ( Drosophila )   HLX1   2.1       213150_at   BF792917   homeobox A10   HOXA10   2.1       214434_at   AB007877   heat shock 70 kDa protein 12A   HSPA12A   2.1       201565_s_at   NM_002166   inhibitor of DNA binding 2, dominant   ID2   2.1               negative helix-loop-helix protein       201888_s_at   U81379   interleukin 13 receptor, alpha 1   IL13RA1   2.1       204465_s_at   NM_004692   internexin neuronal intermediate   INA   2.1               filament protein, alpha       201189_s_at   NM_002224   inositol 1,4,5-triphosphate receptor,   ITPR3   2.1               type 3       212689_s_at   AA524505   jumonji domain containing 1A   JMJD1A   2.1       201776_s_at   AK001487   KIAA0494   KIAA0494   2.1       213157_s_at   BF115148   KIAA0523 protein   KIAA0523   2.1       201596_x_at   NM_000224   keratin 18   KRT18   2.1       204527_at   NM_000259   myosin VA (heavy chain 12, myoxin)   MYO5A   2.1       218231_at   NM_017567   N-acetylglucosamine kinase /// N-   NAGK   2.1               acetylglucosamine kinase       213568_at   AI811298   odd-skipped related 2 ( Drosophila )   OSR2   2.1       203803_at   N45309   prenylcysteine oxidase 1   PCYOX1   2.1       219126_at   NM_018288   PHD finger protein 10   PHF10   2.1       209625_at   BC004100   phosphatidylinositol glycan anchor   PIGH   2.1               biosynthesis, class H       202732_at   NM_007066   protein kinase (cAMP-dependent,   PKIG   2.1               catalytic) inhibitor gamma       203896_s_at   NM_000933   phospholipase C, beta 4   PLCB4   2.1       205934_at   NM_006226   phospholipase C-like 1   PLCL1   2.1       203718_at   NM_006702   patatin-like phospholipase domain   PNPLA6   2.1               containing 6       205933_at   NM_015559   SET binding protein 1   SETBP1   2.1       218720_x_at   NM_012410   seizure related 6 homolog (mouse)-like 2   SEZ6L2   2.1       204362_at   NM_003930   src kinase associated phosphoprotein 2   SKAP2   2.1       202855_s_at   AL513917   solute carrier family 16, member 3   SLC16A3   2.1               (monocarboxylic acid transporter 4)       221041_s_at   NM_012434   solute carrier family 17 (anion/sugar   SLC17A5   2.1               transporter), member 5       220123_at   NM_025181   solute carrier family 35, member F5   SLC35F5   2.1       209748_at   AB029006   spastin   SPAST   2.1       202786_at   NM_013233   serine threonine kinase 39   STK39   2.1               (STE20/SPS1 homolog, yeast)       212625_at   NM_003765   syntaxin 10   STX10   2.1       203310_at   NM_007269   syntaxin binding protein 3   STXBP3   2.1       201079_at   NM_004710   synaptogyrin 2   SYNGR2   2.1       215273_s_at   AK024982   transcriptional adaptor 3 (NGG1   TADA3L   2.1               homolog, yeast)-like       205993_s_at   NM_005994   T-box 2   TBX2   2.1       218996_at   NM_013342   TCF3 (E2A) fusion partner (in   TFPT   2.1               childhood Leukemia)       209118_s_at   AF141347   tubulin, alpha 3   TUBA3   2.1       204141_at   NM_001069   tubulin, beta 2A   TUBB2A   2.1       219201_s_at   NM_020648   twisted gastrulation homolog 1   TWSG1   2.1               ( Drosophila )       214755_at   AK022632   UDP-N-acteylglucosamine   UAP1L1   2.1               pyrophosphorylase 1-like 1       210024_s_at   AB017644   ubiquitin-conjugating enzyme E2E 3   UBE2E3   2.1               (UBC4/5 homolog, yeast)       209551_at   BC004875   Yip1 domain family, member 4   YIPF4   2.1       201662_s_at   D89053   acyl-CoA synthetase long-chain family   ACSL3   2               member 3       201753_s_at   NM_019903   adducin 3 (gamma)   ADD3   2       201952_at   AA156721   activated leukocyte cell adhesion   ALCAM   2               molecule       212747_at   AI990523   ankyrin repeat and sterile alpha motif   ANKS1A   2               domain containing 1A       207076_s_at   NM_000050   argininosuccinate synthetase 1   ASS1   2       213587_s_at   AI884867   ATPase, H+ transporting V0 subunit e2   ATP6V0E2   2       202685_s_at   AI467916   AXL receptor tyrosine kinase   AXL   2       40093_at   X83425   basal cell adhesion molecule (Lutheran   BCAM   2               blood group)       219506_at   NM_024579   chromosome 1 open reading frame 54   C1orf54   2       205575_at   NM_006688   complement component 1, q   C1QL1   2               subcomponent-like 1       204489_s_at   NM_000610   CD44 molecule (Indian blood group)   CD44   2       202910_s_at   NM_001784   CD97 molecule   CD97   2       204039_at   NM_004364   CCAAT/enhancer binding protein   CEBPA   2               (C/EBP), alpha       203973_s_at   NM_005195   CCAAT/enhancer binding protein   CEBPD   2               (C/EBP), delta       209357_at   AF109161   Cbp/p300-interacting transactivator,   CITED2   2               with Glu/Asp-rich carboxy-terminal               domain, 2       211141_s_at   AF180474   CCR4-NOT transcription complex,   CNOT3   2               subunit 3       205229_s_at   AA669336   coagulation factor C homolog, cochlin   COCH   2               ( Limulus polyphemus )       37892_at   J04177   collagen, type XI, alpha 1   COL11A1   2       206100_at   NM_001874   carboxypeptidase M   CPM   2       221988_at   AA463853   Cofactor required for Sp1   CRSP7   2               transcriptional activation, subunit 7,               70 kDa       215785_s_at   AL161999   cytoplasmic FMR1 interacting protein 2   CYFIP2   2       215537_x_at   AJ012008   dimethylarginine   DDAH2   2               dimethylaminohydrolase 2       214027_x_at   AA889653   desmin /// family with sequence   DES /// FAM48A   2               similarity 48, member A       213420_at   AA100250   DEAH (Asp-Glu-Ala-Asp/His) box   DHX57   2               polypeptide 57       200664_s_at   BG537255   DnaJ (Hsp40) homolog, subfamily B,   DNAJB1   2               member 1       205248_at   NM_005128   dopey family member 2   DOPEY2   2       204034_at   NM_014297   ethylmalonic encephalopathy 1   ETHE1   2       219377_at   NM_022751   family with sequence similarity 59,   FAM59A   2               member A       213249_at   AU145127   F-box and leucine-rich repeat protein 7   FBXL7   2       219208_at   NM_025133   F-box protein 11   FBXO11   2       208378_x_at   NM_004464   fibroblast growth factor 5   FGF5   2       208476_s_at   NM_018027   FERM domain containing 4A   FRMD4A   2       218084_x_at   NM_014164   FXYD domain containing ion transport   FXYD5   2               regulator 5       212891_s_at   BF972185   growth arrest and DNA-damage-   GADD45GIP1   2               inducible, gamma interacting protein 1       214510_at   NM_005293   G protein-coupled receptor 20   GPR20   2       212822_at   AA121502   HEG homolog 1 (zebrafish)   HEG1   2       205453_at   NM_002145   homeobox B2   HOXB2   2       204779_s_at   NM_004502   homeobox B7   HOXB7   2       201841_s_at   NM_001540   heat shock 27 kDa protein 1 /// Meis1,   HSPB1 /// MEIS3   2               myeloid ecotropic viral integration site               1 homolog 3 (mouse)       211152_s_at   AF184911   HtrA serine peptidase 2   HTRA2   2       201566_x_at   D13891   inhibitor of DNA binding 2, dominant   ID2 /// ID2B   2               negative helix-loop-helix protein ///               inhibitor of DNA binding 2B, dominant               negative helix-loop-helix protein       201315_x_at   NM_006435   interferon induced transmembrane   IFITM2   2               protein 2 (1-8D)       203336_s_at   AL548363   integrin beta 1 binding protein 1   ITGB1BP1   2       202962_at   NM_015254   kinesin family member 13B   KIF13B   2       209234_at   BF939474   kinesin family member 1B   KIF1B   2       220253_s_at   NM_013437   low density lipoprotein-related protein   LRP12   2               12       201862_s_at   NM_004735   leucine rich repeat (in FLII) interacting   LRRFIP1   2               protein 1       212246_at   BE880828   multiple coagulation factor deficiency 2   MCFD2   2       210087_s_at   AF095727   myelin protein zero-like 1   MPZL1   2       202180_s_at   NM_017458   major vault protein   MVP   2       220319_s_at   NM_013262   myosin regulatory light chain   MYLIP   2               interacting protein       212843_at   AA126505   neural cell adhesion molecule 1   NCAM1   2       212949_at   D38553   non-SMC condensin I complex, subunit H   NCAPH   2       203315_at   BC000103   NCK adaptor protein 2 /// similar to   NCK2 ///   2               NCK adaptor protein 2   LOC729030       200701_at   NM_006432   Niemann-Pick disease, type C2   NPC2   2       219789_at   AI628360   natriuretic peptide receptor C/guanylate   NPR3   2               cyclase C (atrionatriuretic peptide               receptor C)       209262_s_at   BC002669   nuclear receptor subfamily 2, group F,   NR2F6   2               member 6       214130_s_at   AI821791   phosphodiesterase 4D interacting   PDE4DIP ///   2               protein (myomegalin) /// similar to   LOC727942               phosphodiesterase 4D interacting               protein isoform 2       210041_s_at   BC001258   phosphoglucomutase 3   PGM3   2       209803_s_at   AF001294   pleckstrin homology-like domain,   PHLDA2   2               family A, member 2       201860_s_at   NM_000930   plasminogen activator, tissue   PLAT   2       211668_s_at   K03226   plasminogen activator, urokinase ///   PLAU   2               plasminogen activator, urokinase       203467_at   NM_002676   phosphomannomutase 1   PMM1   2       204284_at   N26005   protein phosphatase 1, regulatory   PPP1R3C   2               (inhibitor) subunit 3C       213093_at   AI471375   protein kinase C, alpha   PRKCA   2       219729_at   NM_016307   paired related homeobox 2   PRRX2   2       202458_at   NM_007173   protease, serine, 23   PRSS23   2       205128_x_at   NM_000962   prostaglandin-endoperoxide synthase 1   PTGS1   2               (prostaglandin G/H synthase and               cyclooxygenase)       205503_at   NM_005401   protein tyrosine phosphatase, non-   PTPN14   2               receptor type 14       34478_at   X79780   RAB11B, member RAS oncogene   RAB11B   2               family       210138_at   AF074979   regulator of G-protein signalling 20   RGS20   2       221770_at   BE964473   ribulose-5-phosphate-3-epimerase   RPE   2       202497_x_at   AI631159   solute carrier family 2 (facilitated   SLC2A3   2               glucose transporter), member 3       209712_at   AI769637   solute carrier family 35 (UDP-   SLC35D1   2               glucuronic acid/UDP-N-               acetylgalactosamine dual transporter),               member D1       210001_s_at   AB005043   suppressor of cytokine signaling 1   SOCS1   2       203509_at   NM_003105   sortilin-related receptor, L (DLR class)   SORL1   2               A repeats-containing       210218_s_at   U36501   SP100 nuclear antigen   SP100   2       202506_at   NM_006751   sperm specific antigen 2   SSFA2   2       208992_s_at   BC000627   signal transducer and activator of   STAT3   2               transcription 3 (acute-phase response               factor)       220761_s_at   NM_016281   TAO kinase 3   TAOK3   2       219169_s_at   NM_016020   transcription factor B1, mitochondrial   TFB1M   2       202011_at   NM_003257   tight junction protein 1 (zona occludens   TJP1   2               1)       217730_at   NM_022152   transmembrane BAX inhibitor motif   TMBIM1   2               containing 1       208296_x_at   NM_014350   tumor necrosis factor, alpha-induced   TNFAIP8   2               protein 8       202704_at   AA675892   transducer of ERBB2, 1   TOB1   2       212481_s_at   AI214061   tropomyosin 4   TPM4   2       202124_s_at   AV705253   trafficking protein, kinesin binding 2   TRAK2   2       215047_at   AL080170   tripartite motif-containing 58   TRIM58   2       211701_s_at   AF349720   trophinin /// trophinin   TRO   2       213174_at   BE675549   tetratricopeptide repeat domain 9   TTC9   2       209372_x_at   BF971587   tubulin, beta 2A /// tubulin, beta 2B   TUBB2A ///   2                   TUBB2B       202663_at   AI005043   WAS/WASL interacting protein family,   WIPF1   2               member 1       218110_at   NM_020196   XPA binding protein 2   XAB2   2       220748_s_at   NM_016202   zinc finger protein 580   ZNF580   2            Genes higher expressed in the sensitive RD-1 cells:            204239_s_at   NM_005386   neuronatin   NNAT   −29.9       202942_at   NM_001985   electron-transfer-flavoprotein, beta   ETFB   −26               polypeptide       215731_s_at   X98258   M-phase phosphoprotein 9   MPHOSPH9   −26       219271_at   NM_024572   UDP-N-acetyl-alpha-D-   GALNT14   −22.6               galactosamine:polypeptide N-               acetylgalactosaminyltransferase 14               (GalNAc-T14)       219274_at   NM_012338   tetraspanin 12   TSPAN12   −21.1       209656_s_at   AL136550   transmembrane protein 47   TMEM47   −19.7       204439_at   NM_006820   interferon-induced protein 44-like   IFI44L   −18.4       203510_at   BG170541   met proto-oncogene (hepatocyte growth   MET   −18.4               factor receptor)       206228_at   AW769732   paired box gene 2   PAX2   −18.4       207173_x_at   D21254   cadherin 11, type 2, OB-cadherin   CDH11   −17.1               (osteoblast)       206440_at   NM_004664   lin-7 homolog A ( C. elegans )   LIN7A   −17.1       205352_at   NM_005025   serpin peptidase inhibitor, clade I   SERPINI1   −17.1               (neuroserpin), member 1       218541_s_at   NM_020130   chromosome 8 open reading frame 4   C8orf4   −14.9       206432_at   NM_005328   hyaluronan synthase 2   HAS2   −13.9       202508_s_at   NM_003081   synaptosomal-associated protein,   SNAP25   −13               25 kDa       216005_at   BF434846   Tenascin C (hexabrachion)   TNC   −13       220586_at   NM_025134   chromodomain helicase DNA binding   CHD9   −12.1               protein 9       219908_at   NM_014421   dickkopf homolog 2 ( Xenopus laevis )   DKK2   −12.1       47560_at   AI525402   latrophilin 1   LPHN1   −10.6       206459_s_at   AB045117   wingless-type MMTV integration site   WNT2B   −10.6               family, member 2B       206385_s_at   NM_020987   ankyrin 3, node of Ranvier (ankyrin G)   ANK3   −9.8       207039_at   NM_000077   cyclin-dependent kinase inhibitor 2A   CDKN2A   −9.8               (melanoma, p16, inhibits CDK4)       205003_at   NM_014705   dedicator of cytokinesis 4   DOCK4   −9.8       214829_at   AK023446   aminoadipate-semialdehyde synthase   AASS   −9.2       218775_s_at   NM_024949   WW and C2 domain containing 2   WWC2   −9.2       209732_at   BC005254   C-type lectin domain family 2, member   CLEC2B ///   −8.6               B /// CMT1A duplicated region   CDRT15P               transcript 15 pseudogene       202310_s_at   K01228   collagen, type I, alpha 1   COL1A1   −8.6       36830_at   U80034   mitochondrial intermediate peptidase   MIPEP   −8.6       215008_at   AA582404   tolloid-like 2   TLL2   −8.6       200953_s_at   NM_001759   cyclin D2   CCND2   −8       211155_s_at   D32047   thrombopoietin (myeloproliferative   THPO   −8               leukemia virus oncogene ligand,               megakaryocyte growth and               development factor)       204470_at   NM_001511   chemokine (C—X—C motif) ligand 1   CXCL1   −7.5               (melanoma growth stimulating activity,               alpha)       215231_at   AU144309   Protein kinase, AMP-activated, gamma   PRKAG2   −7               2 non-catalytic subunit       214331_at   AI796813   Ts translation elongation factor,   TSFM   −7               mitochondrial       206001_at   NM_000905   neuropeptide Y   NPY   −6.5       213718_at   BE222257   RNA binding motif protein 4   RBM4   −6.5       205498_at   NM_000163   growth hormone receptor   GHR   −6.1       218717_s_at   NM_018192   leprecan-like 1   LEPREL1   −6.1       205113_at   NM_005382   neurofilament, medium polypeptide   NEFM   −6.1               150 kDa       204081_at   NM_006176   neurogranin (protein kinase C substrate,   NRGN   −6.1               RC3)       207558_s_at   NM_000325   paired-like homeodomain transcription   PITX2   −6.1               factor 2       202659_at   NM_002801   proteasome (prosome, macropain)   PSMB10   −6.1               subunit, beta type, 10       205433_at   NM_000055   butyrylcholinesterase   BCHE   −5.7       214045_at   BF056778   lipoic acid synthetase   LIAS   −5.7       209267_s_at   AB040120   solute carrier family 39 (zinc   SLC39A8   −5.7               transporter), member 8       207850_at   NM_002090   chemokine (C—X—C motif) ligand 3   CXCL3   −5.3       205132_at   NM_005159   actin, alpha, cardiac muscle 1   ACTC1   −4.9       200897_s_at   NM_016081   palladin, cytoskeletal associated protein   PALLD   −4.9       207119_at   NM_006258   protein kinase, cGMP-dependent, type I   PRKG1   −4.9       219498_s_at   NM_018014   B-cell CLL/lymphoma 11A (zinc finger   BCL11A   −4.6               protein)       1405_i_at   M21121   chemokine (C-C motif) ligand 5   CCL5   −4.6       217028_at   AJ224869   chemokine (C—X—C motif) receptor 4   CXCR4   −4.6       219118_at   NM_016594   FK506 binding protein 11, 19 kDa   FKBP11   −4.6       213797_at   AI337069   radical S-adenosyl methionine domain   RSAD2   −4.6               containing 2       204268_at   NM_005978   S100 calcium binding protein A2   S100A2   −4.6       213500_at   AI307760   Coatomer protein complex, subunit beta   COPB2   −4.3               2 (beta prime)       218676_s_at   NM_021213   phosphatidylcholine transfer protein   PCTP   −4.3       211570_s_at   BC004196   receptor-associated protein of the   RAPSN   −4.3               synapse, 43 kD       213591_at   AU149534   Aldehyde dehydrogenase 7 family,   ALDH7A1   −4               member A1       209774_x_at   M57731   chemokine (C—X—C motif) ligand 2   CXCL2   −4       221667_s_at   AF133207   heat shock 22 kDa protein 8   HSPB8   −4       205992_s_at   NM_000585   interleukin 15   IL15   −4       220145_at   NM_024826   microtubule-associated protein 9   MAP9   −4       220346_at   NM_025001   methylenetetrahydrofolate   MTHFD2L   −4               dehydrogenase (NADP+ dependent) 2-               like       210556_at   U85430   nuclear factor of activated T-cells,   NFATC3   −4               cytoplasmic, calcineurin-dependent 3       204589_at   NM_014840   NUAK family, SNF1-like kinase, 1   NUAK1   −4       213817_at   AL049435   CDNA FLJ13601 fis, clone   —   −3.7               PLACE1010069       219973_at   NM_024590   arylsulfatase family, member J   ARSJ   −3.7       213880_at   AL524520   leucine-rich repeat-containing G   LGR5   −3.7               protein-coupled receptor 5       204597_x_at   NM_003155   stanniocalcin 1   STC1   −3.7       208847_s_at   M29872   alcohol dehydrogenase 5 (class III), chi   ADH5   −3.5               polypeptide       212384_at   AI282485   HLA-B associated transcript 1   BAT1   −3.5       211237_s_at   AF202063   fibroblast growth factor receptor 4   FGFR4   −3.5       214604_at   NM_021192   homeobox D11   HOXD11   −3.5       209099_x_at   U73936   jagged 1 (Alagille syndrome)   JAG1   −3.5       219582_at   NM_024576   opioid growth factor receptor-like 1   OGFRL1   −3.5       207943_x_at   NM_006718   pleiomorphic adenoma gene-like 1   PLAGL1   −3.5       202457_s_at   AA911231   protein phosphatase 3 (formerly 2B),   PPP3CA   −3.5               catalytic subunit, alpha isoform               (calcineurin A alpha)       212749_s_at   AI096477   ring finger and CHY zinc finger domain   RCHY1   −3.5               containing 1       215591_at   AK025127   SATB family member 2   SATB2   −3.5       205609_at   NM_001146   angiopoietin 1   ANGPT1   −3.2       202370_s_at   NM_001755   core-binding factor, beta subunit   CBFB   −3.2       221521_s_at   BC003186   GINS complex subunit 2 (Psf2   GINS2   −3.2               homolog)       201036_s_at   NM_005327   hydroxyacyl-Coenzyme A   HADH   −3.2               dehydrogenase       213032_at   AI186739   nuclear factor I/B   NFIB   −3.2       206653_at   BF062139   polymerase (RNA) III (DNA directed)   POLR3G   −3.2               polypeptide G (32 kD)       213852_at   BG289199   RNA binding motif protein 8A   RBM8A   −3.2       210432_s_at   AF225986   sodium channel, voltage-gated, type III,   SCN3A   −3.2               alpha       221495_s_at   AF322111   transcription factor 25 (basic helix-   TCF25 /// MXRA7   −3.2               loop-helix) /// matrix-remodelling               associated 7       220104_at   NM_020119   zinc finger CCCH-type, antiviral 1   ZC3HAV1   −3.2       201067_at   BF215487   —   —   −3       212126_at   BG391282   CDNA clone IMAGE: 4842353   —   −3       211148_s_at   AF187858   angiopoietin 2   ANGPT2   −3       203264_s_at   NM_015185   Cdc42 guanine nucleotide exchange   ARHGEF9   −3               factor (GEF) 9       219023_at   NM_018569   chromosome 4 open reading frame 16   C4orf16   −3       206070_s_at   AF213459   EPH receptor A3   EPHA3   −3       214240_at   AL556409   galanin   GAL   −3       220085_at   NM_018063   helicase, lymphoid-specific   HELLS   −3       213359_at   W74620   Heterogeneous nuclear   HNRPD   −3               ribonucleoprotein D (AU-rich element               RNA binding protein 1, 37 kDa)       210112_at   U96721   Hermansky-Pudlak syndrome 1   HPS1   −3       219213_at   NM_021219   junctional adhesion molecule 2   JAM2   −3       222018_at   AI992187   nascent-polypeptide-associated   NACA /// NACAP1   −3               complex alpha polypeptide /// nascent-   /// LOC389240               polypeptide-associated complex alpha               polypeptide pseudogene 1 /// similar to               nascent polypeptide-associated               complex alpha polypeptide       219368_at   NM_021963   nucleosome assembly protein 1-like 2   NAP1L2   −3       220741_s_at   NM_006903   pyrophosphatase (inorganic) 2 ///   PPA2 /// TRIM69   −3               tripartite motif-containing 69       203789_s_at   NM_006379   sema domain, immunoglobulin domain   SEMA3C   −3               (Ig), short basic domain, secreted,               (semaphorin) 3C       215389_s_at   X79857   troponin T type 2 (cardiac)   TNNT2   −3       203869_at   AK024318   ubiquitin specific peptidase 46   USP46   −3       213790_at   W46291   CDNA FLJ31066 fis, clone   —   −2.8               HSYRA2001153       219474_at   NM_024616   chromosome 3 open reading frame 52   C3orf52   −2.8       209446_s_at   BC001743   chromosome 7 open reading frame 44   C7orf44   −2.8       219555_s_at   NM_018455   centromere protein N   CENPN   −2.8       208968_s_at   BC002568   cytokine induced apoptosis inhibitor 1   CIAPIN1   −2.8       201733_at   AA902971   chloride channel 3   CLCN3   −2.8       203498_at   NM_005822   Down syndrome critical region gene 1-   DSCR1L1   −2.8               like 1       222104_x_at   AI569458   general transcription factor IIH,   GTF2H3   −2.8               polypeptide 3, 34 kDa       209256_s_at   AF277177   KIAA0265 protein   KIAA0265   −2.8       209211_at   AF132818   Kruppel-like factor 5 (intestinal)   KLF5   −2.8       211042_x_at   BC006329   melanoma cell adhesion molecule ///   MCAM   −2.8               melanoma cell adhesion molecule       208754_s_at   AL162068   nucleosome assembly protein 1-like 1   NAP1L1   −2.8       219158_s_at   NM_025085   NMDA receptor regulated 1   NARG1   −2.8       204105_s_at   NM_005010   neuronal cell adhesion molecule   NRCAM   −2.8       201831_s_at   BE875592   p21/Cdc42/Rac1-activated kinase 1   PAK1 /// VDP   −2.8               (STE20 homolog, yeast) /// vesicle               docking protein p115       209486_at   BC004546   disrupter of silencing 10   SAS10   −2.8       219772_s_at   NM_014332   small muscle protein, X-linked   SMPX   −2.8       205444_at   NM_004320   ATPase, Ca++ transporting, cardiac   ATP2A1   −2.6               muscle, fast twitch 1       212189_s_at   AK022874   component of oligomeric golgi   COG4   −2.6               complex 4       213546_at   AL050378   hypothetical protein DKFZp586I1420   DKFZp586I1420   −2.6       212327_at   AK026815   hypothetical protein   DKFZP686A01247   −2.6       219237_s_at   NM_024920   DnaJ (Hsp40) homolog, subfamily B,   DNAJB14   −2.6               member 14       205061_s_at   NM_005033   exosome component 9   EXOSC9   −2.6       207327_at   NM_004100   eyes absent homolog 4 ( Drosophila )   EYA4   −2.6       202771_at   NM_014745   family with sequence similarity 38,   FAM38A   −2.6               member A       219646_at   NM_017702   hypothetical protein FLJ20186   FLJ20186   −2.6       205280_at   NM_000824   glycine receptor, beta   GLRB   −2.6       200853_at   NM_002106   H2A histone family, member Z   H2AFZ   −2.6       219863_at   NM_016323   hect domain and RLD 5   HERC5   −2.6       218604_at   NM_014319   LEM domain containing 3   LEMD3   −2.6       203740_at   NM_005792   M-phase phosphoprotein 6   MPHOSPH6   −2.6       209519_at   BG108193   nuclear cap binding protein subunit 1,   NCBP1   −2.6               80 kDa       201939_at   NM_006622   polo-like kinase 2 ( Drosophila )   PLK2   −2.6       212037_at   BF508848   pinin, desmosome associated protein   PNN   −2.6       202541_at   BF589679   small inducible cytokine subfamily E,   SCYE1   −2.6               member 1 (endothelial monocyte-               activating)       206529_x_at   NM_000441   solute carrier family 26, member 4   SLC26A4   −2.6       201996_s_at   AL524033   spen homolog, transcriptional regulator   SPEN   −2.6               ( Drosophila )       209989_at   AF317549   zinc finger protein 268   ZNF268   −2.6       201307_at   AL534972   septin 11   11-Sep   −2.5       221727_at   AA456973   —   —   −2.5       221844_x_at   AV756161   CDNA clone IMAGE: 6208446   —   −2.5       221217_s_at   NM_018723   ataxin 2-binding protein 1   A2BP1   −2.5       37577_at   U79256   Rho GTPase activating protein 19   ARHGAP19   −2.5       203482_at   AL133215   chromosome 10 open reading frame 6   C10orf6   −2.5       204521_at   NM_013300   chromosome 12 open reading frame 24   C12orf24   −2.5       218447_at   NM_020188   chromosome 16 open reading frame 61   C16orf61   −2.5       213436_at   U73304   cannabinoid receptor 1 (brain)   CNR1   −2.5       205931_s_at   NM_004904   cAMP responsive element binding   CREB5   −2.5               protein 5       201018_at   AL079283   eukaryotic translation initiation factor   EIF1AX   −2.5               1A, X-linked       217820_s_at   NM_018212   enabled homolog ( Drosophila )   ENAH   −2.5       204422_s_at   NM_002006   fibroblast growth factor 2 (basic)   FGF2   −2.5       64900_at   AA401703   hypothetical protein FLJ22167   FLJ22167   −2.5       213094_at   AL033377   G protein-coupled receptor 126   GPR126   −2.5       215030_at   AK023187   G-rich RNA sequence binding factor 1   GRSF1   −2.5       202934_at   AI761561   hexokinase 2   HK2   −2.5       222040_at   AI144007   heterogeneous nuclear   HNRPA1 ///   −2.5               ribonucleoprotein A1 /// hypothetical   LOC728844 ///               protein LOC728844 /// hypothetical   LOC731172               protein LOC731172       212859_x_at   BF217861   metallothionein 1E (functional)   MT1E   −2.5       221916_at   BF055311   neurofilament, light polypeptide 68 kDa   NEFL   −2.5       218375_at   NM_024047   nudix (nucleoside diphosphate linked   NUDT9   −2.5               moiety X)-type motif 9       203060_s_at   AF074331   3′-phosphoadenosine 5′-phosphosulfate   PAPSS2   −2.5               synthase 2       214239_x_at   AI560455   polycomb group ring finger 2   PCGF2   −2.5       213302_at   AL044326   phosphoribosylformylglycinamidine   PFAS   −2.5               synthase (FGAR amidotransferase)       207469_s_at   NM_003662   pirin (iron-binding nuclear protein)   PIR   −2.5       203737_s_at   NM_015062   peroxisome proliferator-activated   PPRC1   −2.5               receptor gamma, coactivator-related 1       218564_at   BC002574   ring finger and WD repeat domain 3   RFWD3   −2.5       215009_s_at   U92014   SEC31 homolog A ( S. cerevisiae )   SEC31A   −2.5       219751_at   NM_024860   SET domain containing 6   SETD6   −2.5       202524_s_at   NM_014767   sparc/osteonectin, cwcv and kazal-like   SPOCK2   −2.5               domains proteoglycan (testican) 2       206415_at   AI769310   tolloid-like 1   TLL1   −2.5       213201_s_at   AJ011712   troponin T type 1 (skeletal, slow)   TNNT1   −2.5       212654_at   AL566786   tropomyosin 2 (beta) /// peptidylprolyl   TPM2 /// PPIL5   −2.5               isomerase (cyclophilin)-like 5       218505_at   NM_024673   WD repeat domain 59   WDR59   −2.5       214714_at   AK022360   zinc finger protein 394   ZNF394   −2.5       218981_at   NM_020186   ACN9 homolog ( S. cerevisiae )   ACN9   −2.3       218868_at   NM_020445   ARP3 actin-related protein 3 homolog   ACTR3B   −2.3               B (yeast)       219384_s_at   NM_012091   adenosine deaminase, tRNA-specific 1   ADAT1   −2.3       201272_at   NM_001628   aldo-keto reductase family 1, member   AKR1B1   −2.3               B1 (aldose reductase)       202268_s_at   NM_003905   amyloid beta precursor protein binding   APPBP1   −2.3               protein 1       213892_s_at   AA927724   adenine phosphoribosyltransferase   APRT   −2.3       209539_at   D25304   Rac/Cdc42 guanine nucleotide   ARHGEF6   −2.3               exchange factor (GEF) 6       212599_at   AK025298   autism susceptibility candidate 2   AUTS2   −2.3       218264_at   NM_016567   BRCA2 and CDKN1A interacting   BCCIP   −2.3               protein       208656_s_at   AF135162   cyclin I   CCNI   −2.3       218803_at   NM_018223   checkpoint with forkhead and ring   CHFR   −2.3               finger domains       200861_at   NM_016284   CCR4-NOT transcription complex,   CNOT1   −2.3               subunit 1       217726_at   NM_016057   coatomer protein complex, subunit zeta 1   COPZ1   −2.3       203880_at   NM_005694   COX17 cytochrome c oxidase assembly   COX17   −2.3               homolog ( S. cerevisiae )       220230_s_at   NM_016229   cytochrome b5 reductase 2   CYB5R2   −2.3       204076_at   AB002390   ectonucleoside triphosphate   ENTPD4   −2.3               diphosphohydrolase 4       203806_s_at   NM_000135   Fanconi anemia, complementation   FANCA   −2.3               group A /// Fanconi anemia,               complementation group A       219901_at   NM_018351   FYVE, RhoGEF and PH domain   FGD6   −2.3               containing 6       205848_at   NM_005256   growth arrest-specific 2   GAS2   −2.3       213129_s_at   AI970157   glycine cleavage system protein H   GCSH ///   −2.3               (aminomethyl carrier) /// similar to   LOC654085 ///               Glycine cleavage system H protein,   LOC730107               mitochondrial precursor /// similar to               Glycine cleavage system H protein,               mitochondrial precursor       214730_s_at   AK025457   golgi apparatus protein 1 /// sema   GLG1 /// SEMA6C   −2.3               domain, transmembrane domain (TM),   /// CDC42SE1               and cytoplasmic domain, (semaphorin)               6C /// CDC42 small effector 1       201348_at   NM_002084   glutathione peroxidase 3 (plasma)   GPX3   −2.3       211998_at   AW138159   H3 histone, family 3B (H3.3B)   H3F3B   −2.3       214059_at   BE049439   Interferon-induced protein 44   IFI44   −2.3       209760_at   AL136932   KIAA0922   KIAA0922   −2.3       221219_s_at   NM_017566   kelch domain containing 4   KLHDC4   −2.3       209840_s_at   AI221950   leucine rich repeat neuronal 3   LRRN3   −2.3       203478_at   NM_002494   NADH dehydrogenase (ubiquinone) 1,   NDUFC1   −2.3               subcomplex unknown, 1, 6 kDa       218888_s_at   NM_018092   neuropilin (NRP) and tolloid (TLL)-like 2   NETO2   −2.3       202432_at   NM_021132   protein phosphatase 3 (formerly 2B),   PPP3CB   −2.3               catalytic subunit, beta isoform               (calcineurin A beta)       221919_at   AW450929   Protein tyrosine phosphatase, receptor   PTPRU   −2.3               type, U       206950_at   NM_002977   sodium channel, voltage-gated, type IX,   SCN9A   −2.3               alpha       209897_s_at   AF055585   slit homolog 2 ( Drosophila )   SLIT2   −2.3       213139_at   AI572079   snail homolog 2 ( Drosophila )   SNAI2   −2.3       205406_s_at   NM_017425   sperm autoantigenic protein 17   SPA17   −2.3       203046_s_at   NM_003920   timeless homolog ( Drosophila )   TIMELESS   −2.3       201377_at   NM_014847   ubiquitin associated protein 2-like   UBAP2L   −2.3       209096_at   U62136   ubiquitin-conjugating enzyme E2   UBE2V2   −2.3               variant 2       201760_s_at   NM_018639   WD repeat and SOCS box-containing 2   WSB2   −2.3       209814_at   BC004421   zinc finger protein 330   ZNF330   −2.3       220709_at   NM_024967   zinc finger protein 556   ZNF556   −2.3       201425_at   NM_000690   aldehyde dehydrogenase 2 family   ALDH2   −2.1               (mitochondrial)       219649_at   NM_013339   asparagine-linked glycosylation 6   ALG6   −2.1               homolog ( S. cerevisiae , alpha-1,3-               glucosyltransferase)       213905_x_at   AA845258   biglycan /// teashirt family zinc finger 1   BGN /// TSHZ1   −2.1       218954_s_at   AF298153   BRF2, subunit of RNA polymerase III   BRF2   −2.1               transcription initiation factor, BRF1-               like       202763_at   NM_004346   caspase 3, apoptosis-related cysteine   CASP3   −2.1               peptidase       221107_at   NM_017581   cholinergic receptor, nicotinic, alpha 9   CHRNA9   −2.1       221139_s_at   NM_015989   cysteine sulfinic acid decarboxylase   CSAD   −2.1       218970_s_at   NM_015960   cutC copper transporter homolog ( E. coli )   CUTC   −2.1       218102_at   NM_015954   2-deoxyribose-5-phosphate aldolase   DERA   −2.1               homolog ( C. elegans )       208810_at   AF080569   DnaJ (Hsp40) homolog, subfamily B,   DNAJB6 ///   −2.1               member 6 /// similar to DnaJ (Hsp40)   LOC387820               homolog, subfamily B, member 6               isoform a       212792_at   AB020684   dpy-19-like 1 ( C. elegans )   DPY19L1   −2.1       205741_s_at   NM_001392   dystrobrevin, alpha   DTNA   −2.1       201632_at   NM_001414   eukaryotic translation initiation factor   EIF2B1   −2.1               2B, subunit 1 alpha, 26 kDa       201437_s_at   NM_001968   eukaryotic translation initiation factor   EIF4E   −2.1               4E       202973_x_at   NM_014883   family with sequence similarity 13,   FAM13A1   −2.1               member A1       218986_s_at   NM_017631   hypothetical protein FLJ20035   FLJ20035   −2.1       53071_s_at   AI885411   hypothetical protein FLJ22222   FLJ22222   −2.1       215143_at   AL049437   Hypothetical protein FLJ36166   FLJ36166   −2.1       208841_s_at   AB014560   GTPase activating protein (SH3   G3BP2   −2.1               domain) binding protein 2       205527_s_at   NM_015487   gem (nuclear organelle) associated   GEMIN4   −2.1               protein 4       206104_at   NM_002202   ISL1 transcription factor,   ISL1   −2.1               LIM/homeodomain, (islet-1)       203162_s_at   NM_005886   katanin p80 (WD repeat containing)   KATNB1   −2.1               subunit B 1       217956_s_at   NM_021204   E-1 enzyme   MASA   −2.1       209585_s_at   AF084943   multiple inositol polyphosphate   MINPP1   −2.1               histidine phosphatase, 1       220615_s_at   NM_018099   male sterility domain containing 1   MLSTD1   −2.1       204326_x_at   NM_002450   metallothionein 1X   MT1X   −2.1       203212_s_at   NM_016156   myotubularin related protein 2   MTMR2   −2.1       218568_at   NM_018238   multiple substrate lipid kinase   MULK   −2.1       202431_s_at   NM_002467   v-myc myelocytomatosis viral   MYC   −2.1               oncogene homolog (avian)       201304_at   NM_005000   NADH dehydrogenase (ubiquinone) 1   NDUFA5   −2.1               alpha subcomplex, 5, 13 kDa       212808_at   AI884627   nuclear factor of activated T-cells,   NFATC2IP   −2.1               cytoplasmic, calcineurin-dependent 2               interacting protein       219031_s_at   NM_016101   nuclear import 7 homolog ( S. cerevisiae )   NIP7   −2.1       202188_at   NM_014669   nucleoporin 93 kDa   NUP93   −2.1       201013_s_at   AA902652   phosphoribosylaminoimidazole   PAICS   −2.1               carboxylase,               phosphoribosylaminoimidazole               succinocarboxamide synthetase       204873_at   NM_000466   peroxisome biogenesis factor 1   PEX1   −2.1       213700_s_at   AA554945   Pyruvate kinase, muscle   PKM2   −2.1       204887_s_at   NM_014264   polo-like kinase 4 ( Drosophila )   PLK4   −2.1       209434_s_at   U00238   phosphoribosyl pyrophosphate   PPAT   −2.1               amidotransferase       201489_at   BC005020   peptidylprolyl isomerase F (cyclophilin   PPIF   −2.1               F)       211737_x_at   BC005916   pleiotrophin (heparin binding growth   PTN   −2.1               factor 8, neurite growth-promoting               factor 1) /// pleiotrophin (heparin               binding growth factor 8, neurite               growth-promoting factor 1)       206290_s_at   NM_002924   regulator of G-protein signalling 7   RGS7   −2.1       219154_at   NM_024714   Ras homolog gene family, member F   RHOF   −2.1               (in filopodia)       214967_at   AU146983   Sterile alpha motif domain containing   SAMD4A   −2.1               4A       221768_at   AV705803   Splicing factor proline/glutamine-rich   SFPQ   −2.1               (polypyrimidine tract binding protein               associated)       213505_s_at   BG252853   splicing factor, arginine/serine-rich 14   SFRS14   −2.1       217289_s_at   AF097831   solute carrier family 37 (glycerol-6-   SLC37A4   −2.1               phosphate transporter), member 4       203580_s_at   NM_003983   solute carrier family 7 (cationic amino   SLC7A6   −2.1               acid transporter, y+ system), member 6       208920_at   AV752215   sorcin   SRI   −2.1       208095_s_at   NM_001222   signal recognition particle 72 kDa   SRP72   −2.1       214597_at   BC000256   somatostatin receptor 2   SSTR2   −2.1       207871_s_at   NM_018412   suppression of tumorigenicity 7   ST7   −2.1       217914_at   NM_017901   two pore segment channel 1   TPCN1   −2.1       218354_at   NM_016209   trafficking protein particle complex 2-   TRAPPC2L   −2.1               like       205300_s_at   NM_022717   U11/U12 snRNP 35K   U1SNRNPBP   −2.1       200667_at   BF448062   ubiquitin-conjugating enzyme E2D 3   UBE2D3   −2.1               (UBC4/5 homolog, yeast)       209137_s_at   BC000263   ubiquitin specific peptidase 10   USP10   −2.1       213256_at   AW593996   membrane-associated ring finger   3-Mar   −2               (C3HC4) 3       208838_at   AB020636   —   —   −2       201872_s_at   AI002002   ATP-binding cassette, sub-family E   ABCE1   −2               (OABP), member 1       202422_s_at   NM_022977   acyl-CoA synthetase long-chain family   ACSL4   −2               member 4       214846_s_at   AB037751   alpha-kinase 3   ALPK3   −2       219437_s_at   NM_013275   ankyrin repeat domain 11   ANKRD11   −2       212211_at   AI986295   ankyrin repeat domain 17   ANKRD17   −2       203350_at   NM_001128   adaptor-related protein complex 1,   AP1G1   −2               gamma 1 subunit       212536_at   AB023173   ATPase, Class VI, type 11B   ATP11B   −2       208764_s_at   D13119   ATP synthase, H+ transporting,   ATP5G2   −2               mitochondrial F0 complex, subunit C2               (subunit 9)       208445_s_at   NM_023005   bromodomain adjacent to zinc finger   BAZ1B   −2               domain, 1B       203796_s_at   AI950380   B-cell CLL/lymphoma 7A   BCL7A   −2       201261_x_at   BC002416   biglycan   BGN   −2       201032_at   NM_006698   bladder cancer associated protein   BLCAP   −2       221776_s_at   AI885109   bromodomain containing 7   BRD7   −2       64432_at   W05463   chromosome 12 open reading frame 47   C12orf47   −2       204215_at   NM_024315   chromosome 7 open reading frame 23   C7orf23   −2       218187_s_at   NM_023080   chromosome 8 open reading frame 33   C8orf33   −2       219644_at   NM_016122   coiled-coil domain containing 41   CCDC41   −2       203166_at   NM_006324   craniofacial development protein 1   CFDP1   −2       218057_x_at   NM_006067   COX4 neighbor   COX4NB   −2       202521_at   NM_006565   CCCTC-binding factor (zinc finger   CTCF   −2               protein)       214743_at   BE046521   cut-like 1, CCAAT displacement   CUTL1   −2               protein ( Drosophila )       201572_x_at   NM_001921   dCMP deaminase   DCTD   −2       202577_s_at   BC005162   DEAD (Asp-Glu-Ala-As) box   DDX19A   −2               polypeptide 19A       202534_x_at   NM_000791   dihydrofolate reductase   DHFR   −2       205762_s_at   NM_007016   dihydrouridine synthase 4-like ( S. cerevisiae )   DUS4L   −2       201540_at   NM_001449   four and a half LIM domains 1   FHL1   −2       218894_s_at   NM_018048   mago-nashi homolog 2   FLJ10292   −2       209702_at   U79260   fatso   FTO   −2       212847_at   AL036840   Far upstream element (FUSE) binding   FUBP1   −2               protein 1       209710_at   AL563460   GATA binding protein 2   GATA2   −2       221028_s_at   NM_030819   glucose-fructose oxidoreductase   GFOD2   −2               domain containing 2 /// glucose-               fructose oxidoreductase domain               containing 2       200708_at   NM_002080   glutamic-oxaloacetic transaminase 2,   GOT2   −2               mitochondrial (aspartate               aminotransferase 2)       214280_x_at   X79536   heterogeneous nuclear   HNRPA1   −2               ribonucleoprotein A1       215513_at   AF241534   hydatidiform mole associated and   HYMAI   −2               imprinted       208937_s_at   D13889   inhibitor of DNA binding 1, dominant   ID1   −2               negative helix-loop-helix protein       203327_at   N22903   insulin-degrading enzyme   IDE   −2       210881_s_at   M17863   insulin-like growth factor 2   IGF2 /// INS-IGF2   −2               (somatomedin A) /// insulin-insulin-               like growth factor 2       205070_at   NM_019071   inhibitor of growth family, member 3   ING3   −2       203607_at   NM_014937   inositol polyphosphate-5-phosphatase F   INPP5F   −2       200079_s_at   AF285758   lysyl-tRNA synthetase /// lysyl-tRNA   KARS   −2               synthetase       213478_at   AB028949   kazrin   KIAA1026   −2       212714_at   AL050205   La ribonucleoprotein domain family,   LARP4   −2               member 4       217506_at   H49382   Hypothetical protein LOC339290   LOC339290   −2       214109_at   AI659561   LPS-responsive vesicle trafficking,   LRBA   −2               beach and anchor containing       204059_s_at   NM_002395   malic enzyme 1, NADP(+)-dependent,   ME1   −2               cytosolic       218654_s_at   NM_016071   mitochondrial ribosomal protein S33   MRPS33   −2       203359_s_at   AL525412   c-myc binding protein   MYCBP   −2       201468_s_at   NM_000903   NAD(P)H dehydrogenase, quinone 1   NQO1   −2       210797_s_at   AF063612   2′-5′-oligoadenylate synthetase-like   OASL   −2       219105_x_at   NM_014321   origin recognition complex, subunit 6   ORC6L   −2               like (yeast)       204004_at   AI336206   PRKC, apoptosis, WT1, regulator   PAWR   −2       213227_at   BE879873   progesterone receptor membrane   PGRMC2   −2               component 2       219459_at   NM_018082   polymerase (RNA) III (DNA directed)   POLR3B   −2               polypeptide B       202313_at   NM_002717   protein phosphatase 2 (formerly 2A),   PPP2R2A   −2               regulatory subunit B (PR 52), alpha               isoform       209049_s_at   BC001004   protein kinase C binding protein 1   PRKCBP1   −2       212610_at   U79291   protein tyrosine phosphatase, non-   PTPN11   −2               receptor type 11 (Noonan syndrome 1)       203831_at   NM_014925   R3H domain containing 2   R3HDM2   −2       218430_s_at   NM_022841   regulatory factor X domain containing 2   RFXDC2   −2       204337_at   AL514445   regulator of G-protein signalling 4   RGS4   −2       212191_x_at   AW574664   ribosomal protein L13   RPL13   −2       213939_s_at   AI871641   RUN and FYVE domain containing 3   RUFY3   −2       209127_s_at   AW173076   squamous cell carcinoma antigen   SART3   −2               recognized by T cells 3       204019_s_at   NM_015677   SH3 domain containing, Ysc84-like 1   SH3YL1   −2               ( S. cerevisiae )       202980_s_at   AI953523   seven in absentia homolog 1   SIAH1   −2               ( Drosophila )       221543_s_at   AL442077   SPFH domain family, member 2   SPFH2   −2       212061_at   AB002330   U2-associated SR140 protein   SR140   −2       215772_x_at   AL050226   succinate-CoA ligase, GDP-forming,   SUCLG2   −2               beta subunit       222116_s_at   AL157485   TBC1 domain family, member 16   TBC1D16   −2       212282_at   BF038366   transmembrane protein 97   TMEM97   −2       214948_s_at   AL050136   TATA element modulatory factor 1   TMF1   −2       202330_s_at   NM_003362   uracil-DNA glycosylase   UNG   −2       213480_at   AF052100   vesicle-associated membrane protein 4   VAMP4   −2       220917_s_at   NM_025132   WD repeat domain 19   WDR19   −2       216350_s_at   X52332   zinc finger protein 10   ZNF10   −2       209538_at   U69645   zinc finger protein 32   ZNF32   −2       214761_at   AW149417   zinc finger protein 423   ZNF423   −2       205739_x_at   NM_016220   zinc finger protein 588   ZNF588   −2       206583_at   NM_017776   zinc finger protein 673   ZNF673   −2               Gene expression profiles of compound 1 sensitive RMS cell line RD-1 (IC 50  = 0.238 μM) and the acquired resistant RD-1 cells has (IC 50  = 1.999 μM) which is more than 8 fold of the parental RD1 was compared and analyzed using using GeneChip ® Expression Analysis software MAS 5.0 to identify genes differentially expressed between these cells.       A change call of “increase” or “decrease” in gene expression level was assigned for each probe set and the fold change between the resistant RD-1 cells and the parental sensitive cells was calculated.       The redundant probes were removed and left one as the representative for the gene.       The fold change is listed, the positive indicates higher expression in the resistant RD-1, and the negative indicates the higher expression in the sensitive parental RD-1.            
These genes may reflect the mechanism of acquired resistance to IGF1R inhibitor. Interestingly, several insulin-like growth factor binding proteins were expressed at higher level in the acquired resistant cells compared to the sensitive parent RD-1, such as IGFBP2 (10.6 fold), IGFBP3 (6.4 fold), IGFBPS (4.8 fold), IGFBP7 (15 fold), whereas, IGF2 had conversely expression pattern. SRC family members FYN and LYN also had increased expression levels in the acquired resistant cells. Comparison of the genes correlated with the intrinsic (de novo) resistance (Table 3) to the ones related to acquired resistance (Table 8), there are common genes, such as CAST, CD44, PLAUR, SP100, STK10, TFPI2 and THBS1 with higher expression in both de novo and acquired resistant cells, suggesting there may be some common mechanisms for both types of drug resistance. Thrombospondin 1 (THBS1) was reported to prevent camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells, this shed new light on a possible role for THBS 1 in drug resistance (G. Rath, et al., Biochim. Biophys. Acta., October;1763(10):1125-34 (2006)). THBS1 was up regulated by IGF stimulation to promote cell survival (data not shown) and over expressed in the resistant cells, and thus may involved in both de novo and acquired resistance to IGF1R inhibitors.
 
Significant Differences in Multiple Pathways Between the Sensitive and Resistant Cell Lines at Basal Level:
 
     Global pathway analysis on the basal gene expression of 28 cell lines using globaltest indicated that 75 out 183 tested pathways were significantly associated with the sensitive/resistant classification to compound 1 (FEW adjusted p value&lt;0.05). Several interesting pathways including apoptosis pathway, and signaling pathways of MAPK, TGFβ, Jak-STAT, insulin, VEGF and natural killer cell mediated cytotoxicity were among those significant pathways that were different between the sensitive and resistant cell lines, while mTOR signaling pathway is different (p value=0.0005) yet slightly higher than the the significance cutoff (FWE adjusted p value=0.0559). Pathway analysis of expression data for the compound 1 treated Rh41 cell compared to that for the untreated control cells, above mentioned pathways are also different between the cells treated with or without the drug with p value all less than 0.01 but not reach the statistical significant cutoff based on the FWE adjusted p values. 
     Ingenuity pathway analysis on the 497 probe sets that significantly correlated with the sensitivity of compound 1 in the 28-cell line panel were performed, over expression of multiple kinases (e.g., EGFR, MET, TGFβR2) in the compound 1 resistant cell lines was observed in the most significant network. This may explain why these cell lines are still proliferating and surviving even in presence of the drug, since they use alternative growth signal pathways instead of IGF1R. In this specific situation, targeting multiple pathways may be necessary to sufficiently inhibit the growth of these cells and synergistic effects with the combination of inhibitors targeting these kinases could be possible. 
     Synergistic Activity Between Inhibitors of IGF1R and Other Kinases: 
     IGF signaling through IGF1R has also been shown to protect cancer cells from the cytotoxic effects of chemotherapy and radiation, and this may be an important factor in tumor cell drug resistance (J. Gooch, et al., Breast Cancer Res. Treat., 56(1): 1-10 (1999), B. Turner, et al., Cancer Res, 57(15):3079-83 (1997)). Recent evidence suggests that resistance to Herceptin® in some forms of breast cancer may be due to activation of IGF1R signaling in those cancers (Y. Lu, et al., J. Natl. Cancer Inst., 93(24):1852-7 (2001)). Tumor cells rely on alternative receptors for activation of critical signaling pathways, therefore, strategies designed to block signaling from multiple receptors may be advantageous. Due to the wide expression of IGF1R and the potential cross-talk between the IGF1R pathway and the other signaling pathways implicated in oncogenesis (EGFR, Her2 and mTOR), IGF1R inhibitors may have potential to be combined with other therapies in a wide range of tumors to increase the overall survival of patients. Through ingenuity pathway analysis, the overexpression of multiple kniases (EGFR, MET, TGFR) in the compound 1 resistant cell lines was observed to be within the top network. Given the important roles of IGF1R, EGFR and Her2 in cell cycle progression, we carried out combination studies to investigate whether inhibition of multiple targets might result in enhanced inhibition of tumor growth. Table 9 summarizes the data for in vitro combination studies in multiple types of tumor cell lines and indicated that the drug combinations resulted in synergistic effects between IGF1R inhibitor compound 1 and various inhibitors of EGFR, including both Her 1 and/or Her2 inhibitors in the forms of either antibody (cetuximab) or small molecules (gefitnib, erlotinib and lapatinib). 
                                   TABLE 9                   In vitro combination study of compound 1 with other       anti-tumor agents in multiple cell lines: IGF1R-       sal, Colo205, RD1, HT-29, WiDr, GEO, MDA-PCa-2b,       MCF-7, H3396, N-87, BT474, and SKBR3 cell lines.                Class/Compound   Combination Result                       HER1/HER2 Inhibitor               cetuximab   Synergy           gefitnib   Synergy           erlotinib   Synergy           lapatinib   Synergy           Other targets           dasatinib   Synergy           Cytotoxic           paclitaxel   Additive           cisplatin   Additive           VP-16   Additive           ADR   Additive           vincristine   Additive                       The combination results were analyzed by Isobolograms.            
These results confirmed our hypothesis based on the pathway analysis. In vivo synergistic effects were also observed in selected xenograft models (data not shown). In addition, combination between multiple cytotoxic agents and compound 1 also resulted in additive activity.
 
     Increased expression level of SRC family members FYN (3 fold) and LYN (11 fold) in the compound 1 acquired resistant RD-1 cells may suggest SRC family members act as an alternative signal pathway to play an important role in growth and survival of the acquired resistant cells, and targeting IGF1R in this case is not sufficient enough. Targeting multiple pathways could be one of ways to prevent the acquired resistance. The results in Table 9 also demonstrated that synergistic effect observed between IGF1R inhibitor compound 1 and dasatinib, a novel, oral, multi-targeted kinase inhibitor that targets important oncogenic pathways, including SRC family kinases, BCR-ABL, PDGFR, c-KIT and EPHA2 (L. Lombardo, et al., J. Med. Chem.;47:6658-61 (2004), A. Todd, et al., PNAS; 102;11011-11016 (2005)). 
     Discussion 
     The development of trastuzumab and EGFR tyrosine kinase inhibitors have demonstrated that careful measurement of biomarkers is necessary when only a small percentage of patients have receptor-driven tumors. Identification of molecular markers predictive of response to IGF1R inhibitors could assist in clinical development by selecting patients most likely to derive clinical benefit. In the present study, by utilizing both microarray gene expression profiling and LC/MS based “bottom-up” protein profiling technologies and a panel of 29 sarcoma and neuroblastoma cell lines, we identified genes and proteins that differentially expressed between the sensitive and resistant cell lines to IGF1R inhibitors compound 2 and compound 1. Realizing the sensitivity/resistance demarcation in the panel of the cell lines is arbitrarily defined and its relevance to the peak range of the drug concentrations in plasma of patients treated with the clinical achievable dose is unclear, we applied Pearson correlation analysis of expression levels with IC 50  values to identify genes/protein correlated with the sensitivity of the drugs in combination with two-sample t-test. 
     There is a correlation between sensitive/resistant classification to IGF1R inhibitors and different sub-types of cell lines. Notably, most of neuroblastoma, Ewing&#39;s and RMS cell lines are sensitive to the inhibitors, making these cell types as the preferred targeting population for IGF1R inhibitors. However, it may create potential possibility of the markers identified are the ones reflecting the specific cell types rather than reflecting the sensitivity of cells to the IGF1R inhibitors. This is not the case for two reasons: first, the sensitive cell lines are consisted of three cell types rather than a single one, and vise visa for the resistant cell llines; second, comparing the drug sensitivity markers identified in this study with the signatures for specific subtypes of sarcomas further excluded the possibility. 
     A number of gene expression profiling studies of soft tissue tumors have identified the signatures for specific subtypes of sarcomas (C. Baer, et al., Int. J. Cancer,110(5):687-94 (2004), K. Baird, et al., Cancer Res., 65: (20)9226-35 (2005), T. Nielsen, et al., Lancet, 359(9314):1301-7 (2002)). For example, the top discriminators for Ewing&#39;s sarcoma include FVT1, DCC, DKK2, PAX3 and JAK1; for fibrosarcoma are PMP22, PTPRZ1, FN1; for RMS are MYL4, FGFR4, TNN11, ACTC, FLNC, and CDH15; for liposarcoma are PPARG, FABP4, FALCS, SH3KBP1, HOXAS and AIM1, for leiomyosarcoma MYLK, CCN1, PBX1 and SLMAP. The comparison results indicated that none of the subtype specific markers are among the intrinsic sensitivity markers we identified. 
     Since IGF1R plays a role in cell survival and in resistance to the anti-HER2 monoclonal antibody trastuzumab, the expression patterns of the components of IGFs/IGF1R system were evaluated in this study to see if they have any correlation with the intrinsic sensitivity/resistance to IGF1R inhibitors in the panel of cell lines. The results showed that IGF1R expression level was not significantly correlated to the sensitivity of compound 2 and/or compound 1 in the 29 sarcoma cell lines even through some of the sensitive cell lines had higher IGF1R expression, this does not exclude the possibility that the sensitive cell lines have elevated activity of IGF1R or IGF1R is the major player for the growth of these cell lines. On the other hand, one member of the IGF-binding proteins (IGFBPs), IGFBP6, was significantly higher (&gt;10 fold) in the group of resistant cell lines at basal level. Intriguingly, in the compound 1 acquired resistant RD-1 cells, IRS2 was 2 fold and IGFBP2, IGFBP 3, IGFBP 5 and IGFBP 7 were 7 to 15 fold elevated compared to the parent sensitive cells. IRS2 is the substrate for IGF1R and can enhance the IGF1R activity associated with a metastatic phenotype which correlated with increased migration and motility (J. Jackson, et al., Oncogene, 20(50): 7318-25 (2001)). IGFBPs influenced IGF signaling by modulate the bioavailability and bioactivity of the IGFs. Several IGFBPs are implicated in drug resistance. IGFBP3 and IGFBP5 were reported to be significantly higher from ovarian cancer non-response patients to aromatase inhibitor letrozole compared with responders (G. Walker, et al., Clin. Cancer Res., 13(5):1438-44 (2007)). IGFBP-2 mRNA and protein level were found to be overexpressed in resistant cell lines to antiestrogen Faslodex/Fulvestrant, tamoxifen or RU 58,668 (A. Juncker-Jensen, et al., Growth Horm. IGF. Res., 16(4):224-39 (2006)). IGFBPs&#39; actions can be modulated by IGFBP proteases, such as cathepsins that cleave IGFBPs. Higher basal expression level (4 to 12 fold) of lysosomal cysteine protease cathepsin B, L and Z and lysosomal aspartyl protease cathepsin D were observed in the resistant cell lines. In cancer patients, elevated cathepsin B activity correlates to poor therapy outcome. Several studies have shown that levels of cathepsin B and/or cathepsin L are correlated with drug-resistance (e.g., adriamycin) (M. Osmak, et al., Anticancer Res., 21(1A):481-3 (2001), P. Scaddan, et al., Invasion Metastasis., 13(6):301-13 (1993)). Cathepsin L acts as a cell survival molecule responsible for initiation of resistance to chemotherapy, inhibition of cathepsin L with siRNA facilitates induction of senescence and reversal of drug resistance (A. Juncker-Jensen, et al., Growth Horm. IGF Res., 16(4):224-39 (2006)). The association between drug-resistance and cathepsin D was also studied in nine cervical and laryngeal carcinoma cell lines resistant to different cytostatics, and all drug resistant cell lines had increased concentration of cathepsin D (M. Osmak, et al., Anticancer Res., July-August;19(4B):3193-7 (1999)). 
     Another group of genes involved in the intrinsic (de novo) drug resistance to 
     IGF1R inhibitors was metallothionein family members (1F, G, H, M, X, 2A), with over-expression (4 to 9 fold) in resistant cell lines. Metallothionein family members are cysteine-rich proteins that involved in many pathophysiological processes such as metal ion homeostasis and detoxification, protection against oxidative damage, cell proliferation and apoptosis, chemo-resistance (platinum agents, tamoxifen) and radiotherapy resistance (M. Ebadi, et al., Gen Pharmacol., 25(7):1297-310 (1994)). The basal level overexpression of these family members was also observed in a group of colon cancer lines that are resistant to compound 1 compared to the sensitive cell lines, suggesting the role of metallothionein family members in IGF1R inhibitor drug resistance. 
     Inhibition of oncogenic protein kinases by small molecule inhibitors has proven to be a valuable strategy for the directed and target-specific treatment of an ever-increasing number of cancer types. Unfortunately, initially successful therapy is often hampered by relatively rapid onset of resistance to the drug and subsequent relapse, particularly in patients with advanced disease. In addition to deriving mutations, loss of target dependence due to the activation of parallel signaling pathways has been also reported as cause for acquired drug resistance. Therefore, novel therapeutic approaches are based on concepts to prevent or circumvent drug resistance, e.g., with target-specific novel drugs interfering with signaling and apoptotic pathways. Revelation of mechanistic details of drug resistance also provides the basis for the development of therapies with novel or conventional antitumor drugs in combination with specific inhibitors to re-establish chemosensitivity. From the present study, it is noteworthy that in the cell lines with de novo resistant to IGF1R inhibitors, other tyrosine kinases such as Met and EGFR were overexpressed. Furthermore, SRC family members FYN and LYN also increased expression levels in the compound 1 acquired resistant cells. These observations may suggest that loss of IGF1R dependence due to overexpression of other kinases and activation of different signal pathways plays an important role as one of the possible mechanisms in the de novo and acquired resistances to IGF1R inhibitors. It is possible that in the IGF 1R inhibitor resistant cell lines, MET and EGFR pathways are presumably more activated and are major factors for the growth signaling, so targeting only IGF1R is not sufficient enough to inhibit growth of these cells. 
     The same hypothesis could be applied to the IGF1R inhibitor acquired resistant cells because SRC family members FYN and LYN elevated their expression level after the IGF1R inhibitor treatment. Based on these observations, we hypothesize that there should be a potential sensitize activity between IGF1R inhibitors and inhibitors for Met, EGFR or SRC pathways. The combination studies in several tumor cell lines (Table 9) actually demonstrated the synergy effects between IGF1R inhibitor compound 1 and multiple HER1/HER2 inhibitors or dasatinib, a multi-targeted kinase inhibitor that targets important oncogenic pathways including SRC family kinases. The same synergy effects were also observed for IGF1R inhibitor compound 2 (data not show). The results further support the observation that co-inhibition of IGF1R and EGFR synergistically sensitizes cancer cells to induce apoptosis (A. Camirand, et al., Breast Cancer Res., 7(4):R570-9 (2005), J. Steinbach, et al., Biochem. Biophys. Res. Commun., 321(3):524-30 (2004)). 
     Because the mutations in tyrosine receptor kinases have been linked to the efficacy of the inhibitors targeting these kinases, it is reasonable to ask whether mutations or/and single nucleotide polymorphisms (SNPs) in IGF1R would correlate with the response to the IGF1R inhibitors, compound 2 and compound 1. Sequencing of the IGF1R in Rh41 and RD-1 (sensitive lines), Rh36 (primary resistant line) and resistant RD-1 (acquired resistant line) has shown no mutations or/and SNPs exist that might cause resistance to the IGF1R inhibitors. Interestingly, no specific mutations in IGF receptors or ligands have been identified in human cancers, but there is clear evidence of epigenetic alterations such as the loss of imprinting (LOI) of IGF-II in a variety of human tumors (S. Ranier, et al., Hum. Mol. Genet., 3(2):386 (1994), S. Zhan, et al., Clin. Invest., 94(1): 445-8 (1994)). Furthermore, no SNPs that cause amino acid changes in the IGF1R protein have been reported in the NCBI dbSNP database, the Japanese SNP database or the Incyte Foundation database. In addition, no human inherited disorders are attributed to mutations in IGF1R. In order to further evaluate potential IGF1R mutations in human cancers, we sequenced the human IGF1R gene from a panel of genomic DNA derived from 24 tumor-derived cell lines and from 48 human primary lung tumors and no germline variations or somatic mutations were identified in these tumor/cell line samples during tumorigenesis, although amplification of the IGF1R locus has been reported in a small number of breast cancer and melanoma specimens (A. Almeida, et al., Genes Chromosomes Cancer, 11(1): 63-5 (1994)). 
     From protein profiles of the baseline expression in 29 cell lines, a strikingly large number of the proteins identified are involved in cell adhesion and cell motility and extracellular signaling regulated processes. Most actin binding proteins found were present in lower levels in the IGF1R sensitive cell lines. The overall goal of this study is to understand the difference in the proteomic signatures of resistant and sensitive cell lines. The pattern emerging from these data is a profile of sensitive cell lines with lower levels of cytoskeleton binding proteins, and overall higher levels of DNA and RNA binding proteins found in the nucleus. The open question is how these features confer the sensitivity to IGF1R inhibitors on the sarcoma cell lines studied here. 
     There is differential sensitivity of compound 2 and compound 1 in a pair of human RMS cells that are sensitive (Rh41) or resistant (Rh36) to the drugs in a cellular proliferation assay (Table 1). These two cell lines have different chromosomal translocations: Rh41 cells harbor a PAX3-FKHR translocation, t(2;13)(q35;q14), whereas Rh36 cells harbor a EWS-FLI-1 translocation, t(11;22)(q24;q12). Gene expression revealed that Rh41 cells have a significant higher level of IGF1R but limited expression of IR, the results were confirmed by RT-PCR measurements (IGF1R/IR ratio=445) and by FACS analysis (data not shown). No mutations in the IGF1R were apparent in both cell lines. In general, the level of IGF1R expression has not been correlated with increased sensitivity in multiple cell lines, thus the sensitivity might be due to differential signaling pathways in these cells. In order to better understand the mechanism of the differential sensitivity, the two cell lines were evaluated by drug treatment and global gene/protein profiling to monitor the differential changes in gene/protein expression. Overall, in Rh36 cells the drug had little, to no effect especially at later time points, 36 and 72 hrs. This makes sense considering the drug concentration of compound 1 used in the study, Rh36 is highly resistant. However, in the sensitive cell Rh41, 30% of genes have significant expression changes upon the drug treatment. These genes are mainly involved in apoptosis, cell growth and proliferation, cell cycles and multiple tyrosine kinases pathways as well as the down-stream IGF1R signaling pathways: MAPK, PI3K and AKT. The expression level of survivin was significantly reduced especially at 36 and 72 hours and programmed cell death 4 (PDCD4) was up-regulated by compound 1 treatment in the sensitive Rh41 cells, but not in resistant Rh36 cells. PDCD4 is a tumor suppressor protein and its expression is strongly induced during apoptosis in a number of cell types (0. Afonja, et al., Oncogene, 23(49):8135-45 (2004)). Thus, up-regulation of PDCD4 expression may suggest apoptosis induced by compound 1 in sensitive cell lines only. This is in agreement with Western blot analysis showed both Rh41 and Rh36 cell lines have high expression of pBad, but only Rh41 cells showed significant reduction in pBad activity by 6 hrs of drug treatment. The reduction in pBad activity was accompanied by an increase in apoptosis when cells were exposed to the drugs for 24-48 hrs, followed by a G1 arrest. Remarkable but not complete decrease of Ki-67 in compound 1 treated cells may suggest the inhibitor with the cytostatic rather than cytotoxic effect. The inhibitor may induce apoptosis and lower the survival threshold of cancer cells thereby augmenting a second apoptotic stimulus by another agent in a combination therapy. 
     There are 41% of 183 total tested KEGG pathways significantly different between the sensitive and resistant cell lines to IGF1R inhibitor. This provides a general clue on what are the main differences conferring the cell&#39;s sensitivity to IGF1R inhibitor. For example, apoptosis pathway is one of the differences, many genes promoting apoptosis have higher expression levels in the resistant cell lines. Detailed dissection of the pathway is needed to get insights for whether resistant cell lines have higher threshold to be apoptotic due to presence of other growth signaling pathways (e.g., EGFR, MET) in addition to IGF1R pathway, whereas in the sensitive cell lines, IGF1R is probably the dominant growth and survival driver. 
     In conclusion, molecular characterization of a panel of soft tissue sarcoma cell lines lead to identified signatures or candidate markers correlating with the intrinsic sensitivity in vitro to IGF1R inhibitors, compound 1 and compound 2. Whether these signatures or markers have the utility in predicting the response to IGF1R inhibitors in the patients with sarcoma needs to be tested in clinic. The possible mechanisms for both intrinsic and acquired drug resistances were explored and could be due to the alternative activation of other parallel signaling pathways besides IGF1R. Based on these possible mechanisms, the combination strategies to target multiple pathways was proposed and tested, synergistic activity of inhibitors for IGF1-R and EGFR, or SRC was observed. This provides some clues on the strategies for developing IGF1R inhibitor and possible combination therapies in clinical trials to achieve synergy between inhibitors for IGF1R and other kinases. 
     Example 2 
     Production of Antibodies Against the Biomarkers 
     Antibodies against the biomarkers can be prepared by a variety of methods. For example, cells expressing an biomarker polypeptide can be administered to an animal to induce the production of sera containing polyclonal antibodies directed to the expressed polypeptides. In one aspect, the biomarker protein is prepared and isolated or otherwise purified to render it substantially free of natural contaminants, using techniques commonly practiced in the art. Such a preparation is then introduced into an animal in order to produce polyclonal antisera of greater specific activity for the expressed and isolated polypeptide. 
     In one aspect, the antibodies of the invention are monoclonal antibodies (or protein binding fragments thereof). Cells expressing the biomarker polypeptide can be cultured in any suitable tissue culture medium, however, it is preferable to culture cells in Earle&#39;s modified Eagle&#39;s medium supplemented to contain 10% fetal bovine serum (inactivated at about 56° C.), and supplemented to contain about 10 g/l nonessential amino acids, about 1,00 U/ml penicillin, and about 100 μg/ml streptomycin. 
     The splenocytes of immunized (and boosted) mice can be extracted and fused with a suitable myeloma cell line. Any suitable myeloma cell line can be employed in accordance with the invention, however, it is preferable to employ the parent myeloma cell line (SP2/0), available from the ATCC. After fusion, the resulting hybridoma cells are selectively maintained in HAT medium, and then cloned by limiting dilution as described by Wands et al. (1981, Gastroenterology, 80:225-232). The hybridoma cells obtained through such a selection are then assayed to identify those cell clones that secrete antibodies capable of binding to the polypeptide immunogen, or a portion thereof. 
     Alternatively, additional antibodies capable of binding to the biomarker polypeptide can be produced in a two-step procedure using anti-idiotypic antibodies. Such a method makes use of the fact that antibodies are themselves antigens and, therefore, it is possible to obtain an antibody that binds to a second antibody. In accordance with this method, protein specific antibodies can be used to immunize an animal, preferably a mouse. The splenocytes of such an immunized animal are then used to produce hybridoma cells, and the hybridoma cells are screened to identify clones that produce an antibody whose ability to bind to the protein-specific antibody can be blocked by the polypeptide. Such antibodies comprise anti-idiotypic antibodies to the protein-specific antibody and can be used to immunize an animal to induce the formation of further protein-specific antibodies. 
     Example 3 
     Immunofluorescence Assays 
     The following immunofluorescence protocol may be used, for example, to verify IGF1R biomarker protein expression on cells or, for example, to check for the presence of one or more antibodies that bind IGF1R biomarkers expressed on the surface of cells. Briefly, Lab-Tek II chamber slides are coated overnight at 4° C. with 10 micrograms/milliliter (μg/ml) of bovine collagen Type II in DPBS containing calcium and magnesium (DPBS++). The slides are then washed twice with cold DPBS++ and seeded with 8000 CHO-CCRS or CHO pC4 transfected cells in a total volume of 125 μl and incubated at 37° C. in the presence of 95% oxygen/5% carbon dioxide. 
     The culture medium is gently removed by aspiration and the adherent cells are washed twice with DPBS++ at ambient temperature. The slides are blocked with DPBS++ containing 0.2% BSA (blocker) at 0-4° C. for one hour. The blocking solution is gently removed by aspiration, and 125 μl of antibody containing solution (an antibody containing solution may be, for example, a hybridoma culture supernatant which is usually used undiluted, or serum/plasma which is usually diluted, e.g., a dilution of about 1/100 dilution). The slides are incubated for 1 hour at 0-4° C. Antibody solutions are then gently removed by aspiration and the cells are washed five times with 400 μl of ice cold blocking solution. Next, 125 μl of 1 μg/ml rhodamine labeled secondary antibody (e.g., anti-human IgG) in blocker solution is added to the cells. Again, cells are incubated for 1 hour at 0-4° C. 
     The secondary antibody solution is then gently removed by aspiration and the cells are washed three times with 400 μl of ice cold blocking solution, and five times with cold DPBS++. The cells are then fixed with 125 μl of 3.7% formaldehyde in DPBS++ for 15 minutes at ambient temperature. Thereafter, the cells are washed five times with 400 μl of DPBS++ at ambient temperature. Finally, the cells are mounted in 50% aqueous glycerol and viewed in a fluorescence microscope using rhodamine filters.