Abstract:
A controlled extended drug release technology for the controlled extended release of hydrophobic or hydrophilic drugs or therapeutically active agents consisting of a homogeneous blend of one or more therapeutic agents, gas generators and surrounded by one or more layers of coat made of thermoplastic water insoluble cellulose derivatives, acrylic polymers, superdisintegrants and optionally an oil, antioxidants and electrolytes. The technology platform is capable of releasing therapeutic agents via zero, first or pseudo first order release.

Description:
BACKGROUND OF THE INVENTION 
     Efficacy and safety is paramount in the treatment of disease states with therapeutically active agents. Efficacy is usually as a result of the therapeutic agent reaching its target sites in amounts sufficient to maintain therapeutic levels for a desired period. It is now generally accepted that sustained release of a therapeutically active agent is desirable when treating chronic diseases conditions were current therapy dictates multiple daily dosing and were the half life of the therapeutic agent is short. With traditional sustained-release dosage formulations, particularly matrix based systems, when taken in the morning, the efficacy of the therapeutic agent diminishes at the end of the night and the beginning of the next day. 
     When therapeutics agents are administered orally they must enter the general circulation of the human body in order to reach their target sites of action. They are released in the GIT, and are absorbed into the capillaries and veins of the upper gastrointestinal tract, and transported by the portal vein to the liver. Following their absorption in the intestine, some orally administered therapeutic agents may be subject to a “first pass” clearance by the liver and excreted into bile or converted into pharmacologically inactive metabolites. This can result in a decrease in bioavailability due to the liver removing the therapeutic agent from the bloodstream prior to entering a patient&#39;s general circulation. For a therapeutic agent to overcome a first pass effect it has to be present in amounts that exceed the excretory or metabolic capability of the liver. 
     First pass metabolism makes it difficult to the maintain therapeutic levels of an orally administered therapeutic agent over an extended period such as 12 or 24 hours. 
     One way to overcome this problem is to administer formulations capable of immediate drug release multiple times daily (i.e., 2-4 times daily), but this approach may result in high peaks and low valley effects (i.e., toxic and sub-therapeutic levels) and compliance issues. Another way is to administer formulations, capable of sustained drug release, that are suitable for once-daily administration. Due to the need to reduce the difference between “peak and valley” concentrations and patient compliance issues, once-daily sustained release formulations are preferred. A sustained release formulation, however, may subject the patient to toxic drug levels over part of the dosing period, and sub-therapeutic drug levels over other portions of the dosing period, if the drug release does not occur at appropriate time intervals. The maintenance of therapeutic levels of an orally administered drug over an extended period thus depends upon a drug delivery system capable of providing an appropriate release profile. 
     It can be seen from the foregoing that there is a need in the art to develop a controlled extended drug release technology with or without a loading dose in a tablet, pellet or bead formulation suitable for a more precise zero, first or pseudo first order release of a therapeutic agent, and which, in situations where the drug is subject to “first pass” metabolism, can be used to provide sustained drug delivery, preferably over a 24-hour period, by an amount sufficient to exceed the liver&#39;s metabolic capacity and to maintain therapeutic levels. 
     It was unexpectedly discovered that controlled extended release technology can be used to improve the efficacy of therapeutic agents during the declining phase identified above. 
     BRIEF SUMMARY OF THE INVENTION 
     The present invention pertains to a controlled extended drug release technology suitable for oral administration. It was surprisingly discovered that the invention allows for precise control of the extended release profile of a drug-loaded tablet, pellet or bead. It was also surprisingly discovered that a tablet, pellet or bead containing a gas generator and surrounded by a coat made from a thermoplastic water insoluble cellulose ether or a mixture of the said thermoplastic polymer and acrylic polymers and superdisintegrant and optionally electrolyte, oil and antioxidant resulted in a hydrodynamically buoyant dosage form despite the density of the dosage form. The buoyancy allows for longer resident times in the stomach compared to conventional drug delivery systems. 
     Another surprising aspect is the discovery that the application of a final top coat made from cellulose esters and or acrylic polymers acts as a timing device which can be used to switch on the activity of the dosage form. This will be particularly useful for drugs that require chronotherapeutic delivery. 
     With respect to drugs subject to “first pass” metabolism and those with short half-life, controlled extended drug release can be achieved through the present invention via an optional electrolyte, oil and antioxidant in the coat, and a loading dose, this together with gas generator and thermoplastic coat provides a dose sufficient to exceed the liver&#39;s metabolic capacity and to maintain therapeutic levels, preferably throughout a 24-hour period. 
     Accordingly, an objective of the present invention is a tablet, pellet or bead that can provide a zero, first and pseudo first order release of therapeutic agent. A second objective of the present invention is a tablet, pellet and bead that is capable of controlled extended release of therapeutic agents over 24 hours. Another objective of the present invention is a single orally administrable tablet that can overcome the “first pass” effect by providing a controlled extended release dosage, with or without a loading dose, with drug release sufficient to exceed the liver&#39;s metabolic capacity, and then continue to maintain therapeutic drug levels, preferably over a 24-hour period. A further objective of the present invention is a tablet, pellet or bead which is hydrodynamically buoyant. Yet another objective of the present invention is a controlled extended drug release tablet, pellet or bead with a timing device which can be used to switch on the activity of the dosage form. 
     In a preferred embodiment of the invention, these and other objectives can be accomplished through a drug delivery system that exhibits controlled extended drug release. 
     In a preferred embodiment of the present invention, the tablet, pellet or bead consists of a homogeneous drug loaded central compartment containing a gas generator, optionally oil, and surrounded by a coat made from a thermoplastic water insoluble cellulose ether or a mixture of the said thermoplastic polymer and acrylic polymers and superdisintegrant and optionally electrolyte, oil and antioxidant. In another preferred embodiment of the invention, there is added a top coat made from cellulose esters and or acrylic polymers which acts as a timing device which can be used to switch on the activity of the dosage form. This is particularly useful for drugs that require chronotherapeutic delivery. 
     In yet another preferred embodiment, drugs subject to “first pass” metabolism and those with short half-life, controlled extended drug release can also be achieved via an optional electrolyte in the coat, and a loading dose. This together with gas generator and thermoplastic coat provides a dose sufficient to exceed the liver&#39;s metabolic capacity and to maintain therapeutic levels, preferably throughout a 24-hour period. 
     In a preferred embodiment of the present invention, the active agent in the central compartment can diffuse out, with aid of gas generated by the gas generator. If there is a loading dose present this will be released first. If electrolytes are present in the coat they will ionize and impact on the integrity of the coat. The superdisintegrants act as “spacers” within the coat in the presence of aqueous media, and also impact on the integrity of the coat. Aqueous media will penetrate through the thermoplastic water insoluble cellulose ether or a mixture of the said thermoplastic polymer and acrylic polymers coat into the central drug compartment and cause a cascade of events which include wetting and solution, emulsification, or suspension of the therapeutic agent(s) present and initiation of gas generation. The rate of input and extent of release of the therapeutic agent in the GIT and plasma, can be regulated by varying the composition and relative amounts of the oil and gas generators in the central drug compartment and also by varying the relative ratios of the thermoplastic water insoluble cellulose ether or a mixture of the said thermoplastic polymer and acrylic polymers and superdisintegrant and electrolytes and oil present in the coat(s). The rate of input and extent of release can also be modulated by the relative amount of loading dose, cellulose esters and acrylic polymer top coat used as a timing device if present. 
     The central drug compartment preferably comprises a combination of therapeutic agents or precursors or prodrugs and gas generators. The coating layer(s) are preferably comprised of thermoplastic water insoluble cellulose ethers or a mixture of the said thermoplastic polymers and superdisintegrants or a mixture of the said thermoplastic polymers and superdisintegrants and acrylic polymers or a mixture of the said thermoplastic polymers and superdisintegrants and acrylic polymers and electrolytes. The loading dose top coat preferably comprises of a loading dose of a therapeutic agent and or cellulose ethers and or acrylic polymers and or cellulose esters. The timing device top coat is preferably comprised of acrylic polymers and or cellulose esters. In these embodiments, once administered, the timing device or drug loading top coat if present dissolves away in the GIT, releases the loading dose and exposes the thermoplastic polymer coating layer(s) to GI fluids. The GI fluids cause the electrolytes to ionize and the superdisintegrants to swell and the acrylic polymers to form salts, thus impacting on the integrity of the coat walls or membrane or film, allowing GI fluids to penetrate into the central drug compartment, wetting and dissolving the drug and triggering the formation of gases. Drug is released by migration and diffusion through the thermoplastic polymer coat. The central drug compartment preferably comprises a compressed, extruded or layered blend of active agent and gas generators and optionally oil, which upon exposure to the GI fluid, forms an emulsion, suspension, solution and gas to provide preferably complete drug release. 
     In another embodiment, the loading dose top coat and or timing device top coat can be modified so there are multiple peaks in drug concentration during in-vitro or in-vivo drug release. In yet another preferred embodiment the loading dose top coat and or timing device top coat can be modified so if orally administered before bedtime, this controlled extended drug delivery system could deliver its active agent while the patient is asleep to facilitate optimal therapeutic drug levels just prior to awakening. This is also suitable for drugs that require chronotherapeutic delivery or ailments that mimic the body&#39;s circadian rhythm. 
     Other objects, features and advantages of the present invention will become apparent from the following detailed description. The detailed description and the specific examples, however, indicate only preferred embodiments of the invention. 
     Various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     In a preferred embodiment, the water insoluble thermoplastic polymer is either cellulose or neutral ester copolymer (e.g., neutral methacrylic acid esters such as Eudragit® NE, Eudragite® RL, and Eudragit® RS) or mixture thereof. 
     In still another preferred embodiment, the loading dose is provided by the same or different therapeutic agent(s) in the central drug compartment. 
     In yet another preferred embodiment there is present one or more surface active agents and as an example glyceryl monooleate, sodium lauryl sulphate or glyceryl monostearate. 
     In a preferred embodiment, release of therapeutic agent is characterized by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within two hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within three hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within fours hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within five hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within six hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within eight hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within twelve hours, and greater than 50% is released in 24 hours, or by a dissolution profile in which at least 0.5% to 50% of the therapeutic agent is released within sixteen hours, and greater than 50% is released in 24 hours 
     The oils used in the invention can be one or more selected from Almond Oil, Apricot Kernel Oil, Avocado Oil, Black Currant Oil, 14% GLA, Borage Oil, 20% GLA, Canola Oil, Carrot Oil, Castor Oil, Clove Leaf Oil, Coconut Oil, Corn Oil, Cottonseed Oil, Evening Primrose Oil, 9% GLA, Flaxseed Oil, 55% ALA, Grapeseed Oil, Hazelnut Oil, Hemp Oil, ALA / GLA, Hydrogenated Oils, Jojoba Oil, Golden Jojoba Oil, Water-white Kukui Nut Oil, Macadamia Nut Oil, Oat Oil, Olive Oil, Extra Virgin Olive Oil Pomace/“B” grade, Olive Oil, Pure/NF, Palm Oil, Parsley Seed Oil, Peach Kernel Oil, Peanut Oil, Pecan Oil, Pistachio Oil, Pumpkinseed Oil, Rice Bran Oil, Rose Hip Seed Oil, Rosemary Oil, Safflower Oil, Linoleic&#39; Safflower Oil, High-Oleic, Sesame Oil NF, Sesame Oil Toasted, Soybean Oil, Sunflower Oil, Salad Sunflower Oil High-Oleic, Tea Tree Oil, Vegetable, Glycerine, USP, Walnut Oil, Wheat Germ Oil, Cold-pressed and mineral oil or other similar oils. 
     The gas generators used in the invention can be selected from soluble or insoluble acid sources such as food acids (citric acid, tartaric acid, lactic acid, malic acid, fumaric acid, ascorbic acid, adipic acid, succinic acid); acid anhydrides (succinic anhydride, citric anhydride); acid salts (sodium dihydrogen phosphate, disodium dihydrogen pyrophosphate, sodium dihydrogen citrate, disodium hydrogen citrate) and carbonate sources (sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, sodium sesquicarbonate, sodium glycine carbonate, lysine carbonate, arginine carbonate, amorphous calcium carbonate); and oxygen gas generators such as anhydrous sodium perborate or other suitable generators 
     The antioxidants used in this invention may be selected from ascorbic acid, fumaric acid, malic acid, alpha tocopherol, ascorbic acid palmitate, butylated hydroxyanisole, propyl gallate, sodium ascobate, and sodium metabisulfite or other suitable antioxidants 
     The said invention also accomplishes these and other objectives through a method for preparing a tablet, pellet or bead for use in controlled extended release of therapeutic agent in which dry or wet granulation of an effective amount of therapeutic active agent, or a pharmaceutically acceptable salt thereof, and dry or wet granulating aids, tableting aids and gas generators and optionally oil is carried out using high shear or low shear mixers or fluidbed granulators. If required, the granules are dried, sieved, lubricated, blended before being compressed to form a tablet or pellet to form a central compartment. This is followed by coating using fluid bed or pan coating techniques to apply one or more coats of thermoplastic cellulose ether in combination with an acrylic polymer and or cellulose esters and superdisintegrant and optionally oil and electrolytes. Additionally, a top coat may be added for the purpose of delivering a loading dose and or serving as a timing device made from acrylic polymers or cellulose esters. 
     A preferred embodiment further includes the steps of combining an effective amount of a therapeutic active agent, or a pharmaceutically acceptable salt thereof, gas generators, optionally oil, and extrusion spheronization aids to form beads or pellets made from extrusion spheronization techniques. The beads may also be made by drug powder or solution layering. The beads formed are coated using fluid bed or pan coating to apply one or more coats of thermoplastic cellulose ether in combination with an acrylic polymer and or cellulose esters and superdisintegrant and optionally oil and electrolytes and antioxidants. Additionally a top coat may be added for the purpose of serving as a loading dose and or serving as a timing device made from acrylic polymers or cellulose esters. 
     In a preferred embodiment, a pharmaceutically acceptable acrylic polymer, includes, but is not limited to, acrylic acid and methacrylic acid copolymers, methyl methacrylate copolymers, ethoxyethyl methacrylates, cyanoethyl methacrylate, aminoalkyl methacrylate copolymer, poly(acrylic acid), poly(methacrylic acid), methacrylic acid alkylamide copolyer, poly(methyl methacrylate), poly(methyl methacrylate) copolymer, polyacrylamide, aminoalkyl methacrylate copolymer, poly(methacrylic acid anhydride), and glycidyl methacrylate copolymers. Additionally, the acrylic polymers may be cationic, anionic, or non-ionic polymers and may be acrylates, methacrylates, formed of methacrylic acid or methacrylic acid esters. The polymers may also be pH independent or pH dependent. 
     It is to be understood that more than one therapeutically active agent may be incorporated into the device of this invention, and that the use of the term “agent” or “drug” in no way excludes the use of two or more such agents or drugs. The therapeutic agents can be in various forms, such as uncharged molecules, components of molecular complexes or nonirritating, pharmacologically acceptable salts. Also, simple derivatives of the agents (such as ethers, esters, amides, etc.) which are easily hydrolyzed by body pH, enzymes, etc., can be employed. 
     The term “therapeutically active agent”, or “therapeutic agent”, or “active agent” as used herein refers to an agent, drug, compound, composition of matter or mixture thereof which provides some biological, often beneficial, effect. This includes pesticides, herbicides, germicides, biocides, algaecides, rodenticides, fungicides, insecticides, antioxidants, plant growth promoters, plant growth inhibitors, preservatives, antipreservatives, disinfectants, sterilization agents, catalysts, chemical reactants, fermentation agents, foods, food supplements, nutrients, cosmetics, drugs, vitamins, sex sterilants, fertility inhibitors, fertility promoters, microorganism attenuators and other agents that benefit the environment of use. As used herein, the terms further include any physiologically or pharmacologically active substance that produces a localized or systemic effect or effects in animals, including warm blooded mammals, humans and primates; avians; domestic household or farm animals such as cats, dogs, sheep, goats, cattle, horses and pigs; laboratory animals such as mice, rats and guinea pigs; fish; reptiles; zoo and wild animals; and the like. 
     The active agent that can be delivered includes inorganic and organic compounds, including, without limitation, drugs which act on the peripheral nerves, adrenergic receptors, cholinergic receptors, the skeletal muscles, the cardiovascular system, smooth muscles, the blood circulatory system, synoptic sites, neuroeffector junctional sites, endocrine and hormone systems, the immunological system, the reproductive system, the skeletal system, autacoid systems, the alimentary and excretory systems, the histamine system and the central nervous system. Suitable active agents may be selected from, for example, proteins, enzymes, hormones, polynucleotides, nucleoproteins, polysaccharides, glycoproteins, lipoproteins, polypeptides, steroids, hypnotics and sedatives, psychic energizers, tranquilizers, anticonvulsants, muscle relaxants, antiparkinson agents, analgesics, anti-inflammatories, local anesthetics, muscle contractants, antimicrobials, antimalarials, hormonal agents including contraceptives, sympathomimetics, polypeptides and proteins capable of eliciting physiological effects, diuretics, lipid regulating agents, antiandrogenic agents, antiparasitics, neoplastics, antineoplastics, hypoglycemics, nutritional agents and supplements, growth supplements, fats, ophthalmics, antienteritis agents, electrolytes and diagnostic agents. 
     Examples of beneficial active agents useful in this invention include prochlorperazine edisylate, ferrous sulfate, aminocaproic acid, mecaxylamine hydrochloride, procainamide hydrochloride, amphetamine sulfate, methamphetamine hydrochloride, benzphetamine hydrochloride, isoproteronol sulfate, phenmetrazine hydrochloride, bethanechol chloride, methacholine chloride, pilocarpine hydrochloride, atropine sulfate, scopolamine bromide, isopropamide iodide, tridihexethyl chloride, phenformin hydrochloride, methylphenidate hydrochloride, theophylline cholinate, cephalexin hydrochloride, diphenidol, meclizine hydrochloride, prochlorperazine maleate, phenoxybenzamine, thiethylperazine maleate, anisindione, diphenadione erythrityl tetranitrate, digoxin, isoflurophate, acetazolamide, methazolamide, bendroflumethiazide, chlorpropamide, tolazamide, chlormadinone acetate, phenaglycodol, allopurinol, aluminum aspirin, methotrexate, acetyl sulfisoxazole, hydrocortisone, hydrocorticosterone acetate, cortisone acetate, dexamethasone and its derivatives such as betamethasone, triamcinolone, methyltestosterone, 17-.beta.-estradiol, ethinyl estradiol, ethinyl estradiol 3-methyl ether, prednisolone, 17-.beta.-hydroxyprogesterone acetate, 19-nor-progesterone, norgestrel, norethindrone, norethisterone, norethiederone, progesterone, norgesterone, norethynodrel, aspirin, indomethacin, naproxen, fenoprofen, sulindac, indoprofen, nitroglycerin, isosorbide dinitrate, propranolol, timolol, atenolol, alprenolol, cimetidine, clonidine, imipramine, levodopa, chlorpromazine, methyidopa, dihydroxyphenylalanine, theophylline, calcium gluconate, ketoprofen, ibuprofen, cephalexin, erythromycin, haloperidol, zomepirac, ferrous lactate, vincamine, phenoxybenzamine, milrinone, captropril, mandol, quanbenz, hydrochlorothiazide, ranitidine, flurbiprofen, fenbufen, fluprofen, tolmetin, alclofenac, mefenamic, flufenamic, difuninal, nimodipine, nitrendipine, nisoldipine, nicardipine, felodipine, lidoflazine, tiapamil, gallopamil, amlodipine, mioflazine, lisinopril, enalapril, captoril, ramipril, enalaprilat, famotidine, nizatidine, sucralfate, etintidine, tetratolol, minoxidil, chlordiazepoxide, diazepam, amitriptylin, and imipramine. Further examples are proteins and peptides which include, but are not limited to, insulin, colchicine, glucagon, thyroid stimulating hormone, parathyroid and pituitary hormones, calcitonin, renin, prolactin, corticotrophin, thyrotropic hormone, follicle stimulating hormone, chronic gonadotropin, gonadotropin releasing hormone, bovine somatotropin, porcine somatropin, oxytocin, vasopressin, prolactin, somatostatin, lypressin, pancreozymin, luteinizing hormone, LHRH, interferons, interleukins, growth hormones such as human growth hormone, bovine growth hormone and porcine growth hormone, fertility inhibitors such as the prostaglandins, fertility promoters, growth factors, and human pancreas hormone releasing factor. 
     As used herein, the terms “therapeutically effective” amount or rate refer to the amount or rate of the active agent needed to achieve the desired therapeutic result. 
     The following examples are illustrative only, and not limiting of the remainder of the disclosure in any way whatsoever. 
     EXAMPLE 1 
     (I) Formula of Drug Containing Central Compartment 
     
       
         
               
               
               
               
               
               
             
           
               
                   
               
               
                   
                 Formulation1 
                 Formulation2 
                 Formulation3 
                 Formulation4 
                 Formulation5 
               
               
                   
                 (%) 
                 (%) 
                 (%) 
                 (%) 
                 (%) 
               
               
                   
               
             
             
               
                 Carvedilol 
                 10 
                 10  
                 10  
                 10  
                 10  
               
               
                 Microcrystalline cellulose 
                 25 
                 25  
                 25  
                 72  
                 70  
               
               
                 Lactose 
                 47.26 
                 56  
                 37.7  
                 — 
                 — 
               
               
                 Silicone dioxide 
                  1 
                 1 
                 1 
                 1 
                 — 
               
               
                 Tartaric acid 
                 — 
                 — 
                 2 
                 — 
                 — 
               
               
                 Citric acid 
                 3.51 
                 10  
                 4 
                 5 
                 5 
               
               
                 Calcium carbonate 
                 1.23 
                 — 
                 — 
                 — 
                 — 
               
               
                 Sodium bicarbonate 
                 — 
                 12  
                 6.8 
                 6 
                 6 
               
               
                 Mineral oil 
                 — 
                 2.5 
                 — 
                 — 
                 — 
               
               
                 Coconut oil 
                 2.5 
                 — 
                 3 
                 1 
                 1 
               
               
                 Glyceryl monooleate 
                 — 
                 2 
                 3 
                 — 
                 1 
               
               
                 Sodium lauryl sulphate 
                 — 
                 3 
                 — 
                 — 
                 7 
               
               
                 Polysorbate 80 
                 10 
                 5 
                 7 
                 5 
                 — 
               
               
                 Magnesium Stearate 
                 0.5 
                 0.5 
                 0.5 
                 — 
                 — 
               
               
                 Total 
                 100  
                 100  
                 100  
                 100  
                 100  
               
               
                   
               
             
          
         
       
     
     (II) Manufacture of Drug Containing Tablets/Pellets 
     Formulation 1, 2 or 3 may be used to make tablets or pellets. Carvedilol is mixed with microcystalline cellulose, tartaric acid and or citric acid, calcium carbonate or sodium bicarbonate, oil, glyceryl monooleate, sodium lauryl sulphate, polysorbate 80 and silicon dioxide in a high-shear or low shear mixer granulator or Patterson-Kelley V-blender for 10 minutes. The mixture is then granulated with an organic solvent and dried. Granulation may be done in a fluidbed. Magnesium stearate is added to the dried granules and blended for 5 more minutes in a V-blender. The powder blend is then compressed using an Elizabeth Hata rotary tablet press. 
     (III) Manufacture of Drug Loaded Beads/Pellets 
     Formulation 4 or 5 may be used to make beads. Carvedilol, microcrystalline cellulose, citric acid, sodium bicarbonate, Sodium lauryl sulphate, polysorbate 80, glyceryl monooleate and oil are dry mixed in a low shear mixer and wet granulated. The wet mass is extruded and spheronized using a Caleva extruder and spheronizer. The spheronized beads are dried. 
     (IV) Coating of Tablets, Pellets or Beads 
     Ethylcellulose is dissolved in alcoholic solution. To this is added an acrylic polymer (Eugragit L and Eudragit S), super disintegrant (Crospovidone) and oil (Coconut oil). This is sprayed on the tablets (using a side vented pan coater), pellets or beads (using a fluid bed coater) to form a coat or coats around them to a weight gain of from about 1.0% to about 25%. 
     EXAMPLE 2 
     (I) Formula of Drug Containing Central Compartment 
     
       
         
               
               
               
               
               
               
             
           
               
                   
               
               
                   
                 Formulation1 
                 Formulation2 
                 Formulation3 
                 Formulation4 
                 Formulation5 
               
               
                   
                 (%) 
                 (%) 
                 (%) 
                 (%) 
                 (%) 
               
               
                   
               
             
             
               
                 Venlafaxine Hcl 
                 10 
                 10 
                 10  
                 10  
                 10  
               
               
                 Microcrystalline cellulose 
                 25 
                 25 
                 25  
                 75  
                 78  
               
               
                 Lactose 
                 47.26 
                 64 
                 47.7  
                 — 
                 — 
               
               
                 Silicone dioxide 
                  1 
                  1 
                 1 
                 1 
                 — 
               
               
                 Tartaric acid 
                 — 
                 — 
                 2 
                 — 
                 — 
               
               
                 Citric acid 
                 10.51 
                 10 
                 4 
                 5 
                 5 
               
               
                 Calcium carbonate 
                  4.23 
                 — 
                 — 
                 — 
                 — 
               
               
                 Sodium bicarbonate 
                 — 
                 12 
                 6.8 
                 6 
                 6 
               
               
                 Mineral oil 
                 — 
                 2.5 
                 — 
                 — 
                 — 
               
               
                 Coconut oil 
                 2.5 
                 — 
                 3 
                 1 
                 1 
               
               
                 Polysorbate 80 
                 — 
                  2 
                 — 
                 2 
                 — 
               
               
                 Magnesium Stearate 
                 0.5 
                 0.5 
                 0.5 
                 — 
                 — 
               
               
                 Total 
                 100  
                 100  
                 100  
                 100  
                 100  
               
               
                   
               
             
          
         
       
     
     (II) Manufacture of drug containing tablets/Pellets 
     Formulation 1, 2 or 3 may be used to make tablets or pellets. Venlafaxine is mixed with microcystalline cellulose, tartaric acid and or citric acid, calcium carbonate or sodium bicarbonate, oil, polysorbate 80 and silicon dioxide in a high-shear or low shear mixer granulator or Pafterson-Kelley V-blender for 10 minutes. The mixture is then granulated with an organic solvent and dried. Granulation may be done in a fluidbed. Magnesium stearate is added to the dried granules and blended for 5 more minutes in a V-blender. The powder blend is then compressed using an Elizabeth Hata rotary tablet press. 
     (III) Manufacture of Drug Loaded Beads/Pellets 
     Formulation 4 or 5 may be used to make beads. Venlafaxine, microcrystalline cellulose, citric acid, sodium bicarbonate, polysorbate 80, and oil are dry mixed in a low shear mixer and wet granulated. The wet mass is extruded and spheronized using a Caleva extruder and spheronizer. The spheronized beads are dried. 
     (IV) Coating of Tablets, Pellets or Beads 
     Ethylcellulose is dissolved in alcoholic solution. To this is added Hydroxypropylmethyl cellulose acetate, super disintegrant and sodium chloride. This is sprayed on the tablets, pellets or beads to form a coat or coats around them to a weight gain of from about 1.0% to about 25%. 
     (V) Composition and Addition of Loading Dose of Venlafaxine 5% wt by wt. 
     A loading dose consisting of Venlafaxine is applied as a coat to a weight gain of about 5%. This consists of venlafaxine in a hydroxypropylmethyl cellulose binder solution. 
     (VI) Composition and Addition of Top Coat. 
     The coat is made from Eudragit L and S in ratio of 5:1. and is applied to a coating thickness of from about 1% to about 50% weight gain 
     EXAMPLE 3 
     This is the same as example 2 except that venlafaxine is replaced by paroxetine hydrochloride and sodium chloride is added to the ethylcellulose coat. 
     EXAMPLE 4 
     This is the same as example 2 except that venlafaxine is replaced by metoprolol succinate and sodium chloride and coconut oil are added to ethylcellulose coat 
     EXAMPLE 5 
     This is the same as example 2 except that venlafaxine is replaced by metoprolol succinate and ascorbic acid, sodium chloride and coconut oil are added to the cellulose coat.