Abstract:
The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

Description:
1. BACKGROUND OF THE INVENTION 
     1.1 Technical Field 
     The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with uses for these polynucleotides and proteins, for example in therapeutic, diagnostic and research methods. 
     1.2 Background 
     Technology aimed at the discovery of protein factors (including e.g., cytokines, such as lymphokines, interferons, CSFs, chemokines, and interleukins) has matured rapidly over the past decade. The now routine hybridization cloning and expression cloning techniques clone novel polynucleotides “directly” in the sense that they rely on information directly related to the discovered protein (i.e., partial DNA/amino acid sequence of the protein in the case of hybridization cloning; activity of the protein in the case of expression cloning). More recent “indirect” cloning techniques such as signal sequence cloning, which isolates DNA sequences based on the presence of a now well-recognized secretory leader sequence motif, as well as various PCR-based or low stringency hybridization-based cloning techniques, have advanced the state of the art by making available large numbers of DNA/amino acid sequences for proteins that are known to have biological activity, for example, by virtue of their secreted nature in the case of leader sequence cloning, by virtue of their cell or tissue source in the case of PCR-based techniques, or by virtue of structural similarity to other genes of known biological activity. 
     Identified polynucleotide and polypeptide sequences have numerous applications in, for example, diagnostics, forensics, gene mapping; identification of mutations responsible for genetic disorders or other traits, to assess biodiversity, and to produce many other types of data and products dependent on DNA and amino acid sequences. 
     2. SUMMARY OF THE INVENTION 
     The compositions of the present invention include novel isolated polypeptides, novel isolated polynucleotides encoding such polypeptides, including recombinant DNA molecules, cloned genes or degenerate variants thereof, especially naturally occurring variants such as allelic variants, antisense polynucleotide molecules, and antibodies that specifically recognize one or more epitopes present on such polypeptides, as well as hybridomas producing such antibodies. 
     The compositions of the present invention additionally include vectors, including expression vectors, containing the polynucleotides of the invention, cells genetically engineered to contain such polynucleotides and cells genetically engineered to express such polynucleotides. 
     The present invention relates to a collection or library of at least one novel nucleic acid sequence assembled from expressed sequence tags (ESTs) isolated mainly by sequencing by hybridization (SBM), and in some cases, sequences obtained from one or more public databases. The invention relates also to the proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. These nucleic acid sequences are designated as SEQ ID NO: 1-948 and are provided in the Sequence Listing. In the nucleic acids provided in the Sequence Listing, A is adenine; C is cytosine; G is guanine; T is thymine; and N is any of the four bases. In the amino acids provided in the Sequence Listing, * corresponds to the stop codon. 
     The nucleic acid sequences of the present invention also include, nucleic acid sequences that hybridize to the complement of SEQ ID NO: 1-948 under stringent hybridization conditions; nucleic acid sequences which are allelic variants or species homologues of any of the nucleic acid sequences recited above, or nucleic acid sequences that encode a peptide comprising a specific domain or truncation of the peptides encoded by SEQ ID NO: 1-948. A polynucleotide comprising a nucleotide sequence having at least 90% identity to an identifying sequence of SEQ ID NO: 1-948 or a degenerate variant or fragment thereof. The identifying sequence can be 100 base pairs in length. 
     The nucleic acid sequences of the present invention also include the sequence information from the nucleic acid sequences of SEQ ID NO: 1-948. The sequence information can be a segment of any one of SEQ ID NO: 1-948 that uniquely identifies or represents the sequence information of SEQ ID NO: 1-948. 
     A collection as used in this application can be a collection of only one polynucleotide. The collection of sequence information or identifying information of each sequence can be provided on a nucleic acid array. In one embodiment, segments of sequence information is provided on a nucleic acid array to detect the polynucleotide that contains the segment. The array can be designed to detect full-match or mismatch to the polynucleotide that contains the segment. The collection can also be provided in a computer-readable format. 
     This invention also includes the reverse or direct complement of any of the nucleic acid sequences recited above; cloning or expression vectors containing the nucleic acid sequences; and host cells or organisms transformed with these expression vectors. Nucleic acid sequences (or their reverse or direct complements) according to the invention have numerous applications in a variety of techniques known to those skilled in the art of molecular biology, such as use as hybridization probes, use as primers for PCR, use in an array, use in computer-readable media, use in sequencing full-length genes, use for chromosome and gene mapping, use in the recombinant production of protein, and use in the generation of anti-sense DNA or RNA, their chemical analogs and the like. 
     In a preferred embodiment, the nucleic acid sequences of SEQ ID NO: 1-948 or novel segments or parts of the nucleic acids of the invention are used as primers in expression assays that are well known in the art. In a particularly preferred embodiment, the nucleic acid sequences of SEQ ID NO: 1-948 or novel segments or parts of the nucleic acids provided herein are used in diagnostics for identifying expressed genes or, as well known in the art and exemplified by Vollrath et al., Science 258:52-59 (1992), as expressed sequence tags for physical mapping of the human genome. 
     The isolated polynucleotides of the invention include, but are not limited to, a polynucleotide comprising any one of the nucleotide sequences set forth in SEQ ID NO: 1-948; a polynucleotide comprising any of the full length protein coding sequences of SEQ ID NO: 1-948; and a polynucleotide comprising any of the nucleotide sequences of the mature protein coding sequences of SEQ ID NO: 1-948. The polynucleotides of the present invention also include, but are not limited to, a polynucleotide that hybridizes under stringent hybridization conditions to (a) the complement of any one of the nucleotide sequences set forth in SEQ ID NO: 1-948; (b) a nucleotide sequence encoding any one of the amino acid sequences set forth in the Sequence Listing; (c) a polynucleotide which is an allelic variant of any polynucleotides recited above; (d) a polynucleotide which encodes a species homolog (e.g. orthologs) of any of the proteins recited above; or (e) a polynucleotide that encodes a polypeptide comprising a specific domain or truncation of any of the polypeptides comprising an amino acid sequence set forth in the Sequence Listing. 
     The isolated polypeptides of the invention include, but are not limited to, a polypeptide comprising any of the amino acid sequences set forth in the Sequence Listing; or the corresponding full length or mature protein. Polypeptides of the invention also include polypeptides with biological activity that are encoded by (a) any of the polynucleotides having a nucleotide sequence set forth in SEQ ID NO: 1-948; or (b) polynucleotides that hybridize to the complement of the polynucleotides of (a) under stringent hybridization conditions. Biologically or immunologically active variants of any of the polypeptide sequences in the Sequence Listing, and “substantial equivalents” thereof (e.g., with at least about 65%, 70%, 75%, 80%, 85%, 90%, 95%, 98% or 99% amino acid sequence identity) that preferably retain biological activity are also contemplated. The polypeptides of the invention may be wholly or partially chemically synthesized but are preferably produced by recombinant means using the genetically engineered cells (e.g. host cells) of the invention. 
     The invention also provides compositions comprising a polypeptide of the invention. Polypeptide compositions of the invention may further comprise an acceptable carrier, such as a hydrophilic, e.g., pharmaceutically acceptable, carrier. 
     The invention also provides host cells transformed or transfected with a polynucleotide of the invention. 
     The invention also relates to methods for producing a polypeptide of the invention comprising growing a culture of the host cells of the invention in a suitable culture medium under conditions permitting expression of the desired polypeptide, and purifying the polypeptide from the culture or from the host cells. Preferred embodiments include those in which the protein produced by such process is a mature form of the protein. 
     Polynucleotides according to the invention have numerous applications in a variety of techniques known to those skilled in the art of molecular biology. These techniques include use as hybridization probes, use as oligomers, or primers, for PCR, use for chromosome and gene mapping, use in the recombinant production of protein, and use in generation of anti-sense DNA or RNA, their chemical analogs and the like. For example, when the expression of an mRNA is largely restricted to a particular cell or tissue type, polynucleotides of the invention can be used as hybridization probes to detect the presence of the particular cell or tissue mRNA in a sample using, e.g., in situ hybridization. 
     In other exemplary embodiments, the polynucleotides are used in diagnostics as expressed sequence tags for identifying expressed genes or, as well known in the art and exemplified by Vollrath et al., Science 258:52-59 (1992), as expressed sequence tags for physical mapping of the human genome. 
     The polypeptides according to the invention can be used in a variety of conventional procedures and methods that are currently applied to other proteins. For example, a polypeptide of the invention can be used to generate an antibody that specifically binds the polypeptide. Such antibodies, particularly monoclonal antibodies, are useful for detecting or quantitating the polypeptide in tissue. The polypeptides of the invention can also be used as molecular weight markers, and as a food supplement. 
     Methods are also provided for preventing, treating, or ameliorating a medical condition which comprises the step of administering to a mammalian subject a therapeutically effective amount of a composition comprising a polypeptide of the present invention and a pharmaceutically acceptable carrier. 
     In particular, the polypeptides and polynucleotides of the invention can be utilized, for example, in methods for the prevention and/or treatment of disorders involving aberrant protein expression or biological activity. 
     The present invention further relates to methods for detecting the presence of the polynucleotides or polypeptides of the invention in a sample. Such methods can, for example, be utilized as part of prognostic and diagnostic evaluation of disorders as recited herein and for the identification of subjects exhibiting a predisposition to such conditions. The invention provides a method for detecting the polynucleotides of the invention in a sample, comprising contacting the sample with a compound that binds to and forms a complex with the polynucleotide of interest for a period sufficient to form the complex and under conditions sufficient to form a complex and detecting the complex such that if a complex is detected, the polynucleotide of interest is detected. The invention also provides a method for detecting the polypeptides of the invention in a sample comprising contacting the sample with a compound that binds to and forms a complex with the polypeptide under conditions and for a period sufficient to form the complex and detecting the formation of the complex such that if a complex is formed, the polypeptide is detected. 
     The invention also provides kits comprising polynucleotide probes and/or monoclonal antibodies, and optionally quantitative standards, for carrying out methods of the invention. Furthermore, the invention provides methods for evaluating the efficacy of drugs, and monitoring the progress of patients, involved in clinical trials for the treatment of disorders as recited above. 
     The invention also provides methods for the identification of compounds that modulate (i.e., increase or decrease) the expression or activity of the polynucleotides and/or polypeptides of the invention. Such methods can be utilized, for example, for the identification of compounds that can ameliorate symptoms of disorders as recited herein. Such methods can include, but are not limited to, assays for identifying compounds and other substances that interact with (e.g., bind to) the polypeptides of the invention. The invention provides a method for identifying a compound that binds to the polypeptides of the invention comprising contacting the compound with a polypeptide of the invention in a cell for a time sufficient to form a polypeptide/compound complex, wherein the complex drives expression of a reporter gene sequence in the cell; and detecting the complex by detecting the reporter gene sequence expression such that if expression of the reporter gene is detected the compound the binds to a polypeptide of the invention is identified. 
     The methods of the invention also provides methods for treatment which involve the administration of the polynucleotides or polypeptides of the invention to individuals exhibiting symptoms or tendencies. In addition, the invention encompasses methods for treating diseases or disorders as recited herein comprising administering compounds and other substances that modulate the overall activity of the target gene products. Compounds and other substances can effect such modulation either on the level of target gene/protein expression or target protein activity. 
     The polypeptides of the present invention and the polynucleotides encoding them are also useful for the same functions known to one of skill in the art as the polypeptides and polynucleotides to which they have homology (set forth in Table 2); for which they have a signature region (as set forth in Table 3); or for which they have homology to a gene family (as set forth in Table 4). If no homology is set forth for a sequence, then the polypeptides and polynucleotides of the present invention are useful for a variety of applications, as described herein, including use in arrays for detection. 
    
    
     3. DETAILED DESCRIPTION OF THE INVENTION 
     3.1 Definitions 
     It must be noted that as used herein and in the appended claims, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. 
     The term “active” refers to those forms of the polypeptide which retain the biologic and/or immunologic activities of any naturally occurring polypeptide. According to the invention, the terms “biologically active” or “biological activity” refer to a protein or peptide having structural, regulatory or biochemical functions of a naturally occurring molecule. Likewise “immunologically active” or “immunological activity” refers to the capability of the natural, recombinant or synthetic polypeptide to induce a specific immune response in appropriate animals or cells and to bind with specific antibodies. 
     The term “activated cells” as used in this application are those cells which are engaged in extracellular or intracellular membrane trafficking, including the export of secretory or enzymatic molecules as part of a normal or disease process. 
     The terms “complementary” or “complementarity” refer to the natural binding of polynucleotides by base pairing. For example, the sequence 5′-AGT-3′ binds to the complementary sequence 3′-TCA-5′. Complementarity between two single-stranded molecules may be “partial” such that only some of the nucleic acids bind or it may be “complete” such that total complementarity exists between the single stranded molecules. The degree of complementarity between the nucleic acid strands has significant effects on the efficiency and strength of the hybridization between the nucleic acid strands. 
     The term “embryonic stem cells (ES)” refers to a cell that can give rise to many differentiated cell types in an embryo or an adult, including the germ cells. The term “germ line stem cells (GSCs)” refers to stem cells derived from primordial stem cells that provide a steady and continuous source of germ cells for the production of gametes. The term “primordial germ cells (PGCs)” refers to a small population of cells set aside from other cell lineages particularly from the yolk sac, mesenteries, or gonadal ridges during embryogenesis that have the potential to differentiate into germ cells and other cells. PGCs are the source from which GSCs and ES cells are derived The PGCs, the GSCs and the ES cells are capable of self-renewal. Thus these cells not only populate the germ line and give rise to a plurality of terminally differentiated cells that comprise the adult specialized organs, but are able to regenerate themselves. 
     The term “expression modulating fragment,” EMF, means a series of nucleotides which modulates the expression of an operably linked ORF or another EMF. 
     As used herein, a sequence is said to “modulate the expression of an operably linked sequence” when the expression of the sequence is altered by the presence of the EMF. EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of EMFs are nucleic acid fragments which induce the expression of an operably linked ORF in response to a specific regulatory factor or physiological event. 
     The terms “nucleotide sequence” or “nucleic acid” or “polynucleotide” or “oligonculeotide” are used interchangeably and refer to a heteropolymer of nucleotides or the sequence of these nucleotides. These phrases also refer to DNA or RNA of genomic or synthetic origin which may be single-stranded or double-stranded and may represent the sense or the antisense strand, to peptide nucleic acid (PNA) or to any DNA-like or RNA-like material. In the sequences herein A is adenine, C is cytosine, T is thymine, G is guanine and N is A, C, G or T (U). It is contemplated that where the polynucleotide is RNA, the T (thymine) in the sequences provided herein is substituted with U (uracil). Generally, nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene. 
     The terms “oligonucleotide fragment” or a “polynucleotide fragment”, “portion,” or “segment” or “probe” or “primer” are used interchangeably and refer to a sequence of nucleotide residues which are at least about 5 nucleotides, more preferably at least about 7 nucleotides, more preferably at least about 9 nucleotides, more preferably at least about 11 nucleotides and most preferably at least about 17 nucleotides. The fragment is preferably less than about 500 nucleotides, preferably less than about 200 nucleotides, more preferably less than about 100 nucleotides, more preferably less than about 50 nucleotides and most preferably less than 30 nucleotides. Preferably the probe is from about 6 nucleotides to about 200 nucleotides, preferably from about 15 to about 50 nucleotides, more preferably from about 17 to 30 nucleotides and most preferably from about 20 to 25 nucleotides. Preferably the fragments can be used in polymerase chain reaction (PCR), various hybridization procedures or microarray procedures to identify or amplify identical or related parts of mRNA or DNA molecules. A fragment or segment may uniquely identify each polynucteotide sequence of the present invention. Preferably the fragment comprises a sequence substantially similar to any one of SEQ ID NOs: 1-948. 
     Probes may, for example, be used to determine whether specific mRNA molecules are present in a cell or tissue or to isolate similar nucleic acid sequences from chromosomal DNA as described by Walsh et al. (Walsh, P. S. et al., 1992, PCR Methods Appl 1:241-250). They may be labeled by nick translation, Klenow fill-in reaction, PCR, or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. et al., 1989, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY; or Ausubel, F. M. et al., 1989, Current Protocols in Molecular Biology, John Wiley &amp; Sons, New York N.Y., both of which are incorporated herein by reference in their entirety. 
     The nucleic acid sequences of the present invention also include the sequence information from the nucleic acid sequences of SEQ ID NOs: 1-948. The sequence information can be a segment of any one of SEQ ID NOs: 1-948 that uniquely identifies or represents the sequence information of that sequence of SEQ ID NO: 1-948. One such segment can be a twenty-mer nucleic acid sequence because the probability that a twenty-mer is fully matched in the human genome is 1 in 300. In the human genome, there are three billion base pairs in one set of chromosomes. Because 4 20  possible twenty-mers exist, there are 300 times more twenty-mers than there are base pairs in a set of human chromosomes. Using the same analysis, the probability for a seventeen-mer to be fully matched in the human genome is approximately 1 in 5. When these segments are used in arrays for expression studies, fifteen-mer segments can be used. The probability that the fifteen-mer is fully matched in the expressed sequences is also approximately one in five because expressed sequences comprise less than approximately 5% of the entire genome sequence. 
     Similarly, when using sequence information for detecting a single mismatch, a segment can be a twenty-five mer. The probability that the twenty-five mer would appear in a human genome with a single mismatch is calculated by multiplying the probability for a full match (1÷4 25 ) times the increased probability for mismatch at each nucleotide position (3×25). The probability that an eighteen mer with a single mismatch can be detected in an array for expression studies is approximately one in five. The probability that a twenty-mer with a single mismatch can be detected in a human genome is approximately one in five. 
     The term “open reading frame,” ORF, means a series of nucleotide triplets coding for amino acids without any termination codons and is a sequence translatable into protein. 
     The terms “operably linked” or “operably associated” refer to functionally related nucleic acid sequences. For example, a promoter is operably associated or operably linked with a coding sequence if the promoter controls the transcription of the coding sequence. While operably linked nucleic acid sequences can be contiguous and in the same reading friame, certain genetic elements e.g. repressor genes are not contiguously linked to the coding sequence but still control transcription/translation of the coding sequence. 
     The term “pluripotent” refers to the capability of a cell to differentiate into a number of differentiated cell types that are present in an adult organism. A pluripotent cell is restricted in its differentiation capability in comparison to a totipotent cell. 
     The terms “polypeptide” or “peptide” or “amino acid sequence” refer to an oligopeptide, peptide, polypeptide or protein sequence or fragment thereof and to naturally occurring or synthetic molecules. A polypeptide “fragment,” “portion,” or “segment” is a stretch of amino acid residues of at least about 5 amino acids, preferably at least about 7 amino acids, more preferably at least about 9 amino acids and most preferably at least about 17 or more amino acids. The peptide preferably is not greater than about 200 amino acids, more preferably less than 150 amino acids and most preferably less than 100 amino acids. Preferably the peptide is from about 5 to about 200 amino acids. To be active, any polypeptide must have sufficient length to display biological and/or immunological activity. 
     The term “naturally occurring polypeptide” refers to polypeptides produced by cells that have not been genetically engineered and specifically contemplates various polypeptides arising from post-translational modifications of the polypeptide including, but not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation. 
     The term “translated protein coding portion” means a sequence which encodes for the full length protein which may include any leader sequence or any processing sequence. 
     The term “mature protein coding sequence” means a sequence which encodes a peptide or protein without a signal or leader sequence. The “mature protein portion” means that portion of the protein which does not include a signal or leader sequence. The peptide may have been produced by processing in the cell which removes any leader/signal sequence. The mature protein portion may or may not include the initial methionine residue. The methionine residue may be removed from the protein during processing in the cell. The peptide may be produced synthetically or the protein may have been produced using a polynucleotide only encoding for the mature protein coding sequence. 
     The term “derivative” refers to polypeptides chemically modified by such techniques as ubiquitination, labeling (e.g., with radionuclides or various enzymes), covalent polymer attachment such as pegylation (derivatization with polyethylene glycol) and insertion or substitution by chemical synthesis of amino acids such as omithine, which do not normally occur in human proteins. 
     The term “variant” (or “analog”) refers to any polypeptide differing from naturally occurring polypeptides by amino acid insertions, deletions, and substitutions, created using, e g.; recombinant DNA techniques. Guidance in determining which amino acid residues may be replaced, added or deleted without abolishing activities of interest, may be found by comparing the sequence of the particular polypeptide with that of homologous peptides and minimizing the number of amino acid sequence changes made in regions of high homology (conserved regions) or by replacing amino acids with consensus sequence. 
     Alternatively, recombinant variants encoding these same or similar polypeptides may be synthesized or selected by making use of the “redundancy” in the genetic code. Various codon substitutions, such as the silent changes which produce various restriction sites, may be introduced to optimize cloning into a plasmid or viral vector or expression in a particular prokaryotic or eukaryotic system. Mutations in the polynucleotide sequence may be reflected in the polypeptide or domains of other peptides added to the polypeptide to modify the properties of any part of the polypeptide, to change characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate. 
     Preferably, amino acid “substitutions” are the result of replacing one amino acid with another amino acid having similar structural and/or chemical properties, i.e., conservative amino acid replacements. “Conservative” amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid. “Insertions” or “deletions” are preferably in the range of about 1 to 20 amino acids, more preferably 1 to 10 amino acids. The variation allowed may be experimentally determined by systematically malking insertions, deletions, or substitutions of amino acids in a polypeptide molecule using recombinant DNA techniques and assaying the resulting recombinant variants for activity. 
     Alternatively, where alteration of function is desired, insertions, deletions or non-conservative alterations can be engineered to produce altered polypeptides. Such alterations can, for example, alter one or more of the biological functions or biochemical characteristics of the polypeptides of the invention. For example, such alterations may change polypeptide characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate. Further, such alterations can be selected so as to generate polypeptides that are better suited for expression, scale up and the like in the host cells chosen for expression. For example, cysteine residues can be deleted or substituted with another amino acid residue in order to eliminate disulfide bridges. 
     The terms “purified” or “substantially purified” as used herein denotes that the indicated nucleic acid or polypeptide is present in the substantial absence of other biological macromolecules, e.g., polynucleotides, proteins, and the like. In one embodiment, the polynucleotide or polypeptide is purified such that it constitutes at least 95% by weight, more preferably at least 99% by weight, of the indicated biological macromolecules present (but water, buffers, and other small molecules, especially molecules having a molecular weight of less than 1000 daltons, can be present). 
     The term “isolated” as used herein refers to a nucleic acid or polypeptide separated from at least one other component (e.g., nucleic acid or polypeptide) present with the nucleic acid or polypeptide in its natural source. In one embodiment, the nucleic acid or polypeptide is found in the presence of (if anything) only a solvent, buffer, ion, or other component normally present in a solution of the same. The terms “isolated” and “purified” do not encompass nucleic acids or polypeptides present in their natural source. 
     The term “recombinant,” when used herein to refer to a polypeptide or protein, means that a polypeptide or protein is derived from recombinant (e.g., microbial, insect, or mammalian) expression systems. “Microbial” refers to recombinant polypeptides or proteins made in bacterial or fungal (e.g., yeast) expression systems. As a product, “recombinant microbial” defines a polypeptide or protein essentially free of native endogenous substances and unaccompanied by associated native glycosylation. Polypeptides or proteins expressed in most bacterial cultures, e.g.,  E. coli , will be free of glycosylation modifications; polypeptides or proteins expressed in yeast will have a glycosylation pattern in general different from those expressed in mammalian cells. 
     The term “recombinant expression vehicle or vector” refers to a plasmid or phage or virus or vector, for expressing a polypeptide from a DNA (RNA) sequence. An expression vehicle can comprise a transcriptional unit comprising an assembly of (1) a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, (2) a structural or coding sequence which is transcribed into mRNA and translated into protein, and (3) appropriate transcription initiation and termiination sequences. Structural units intended for use in yeast or eukaryotic expression systems preferably include a leader sequence enabling extracellular secretion of translated protein by a host cell. Alternatively, where recombinant protein is expressed without a leader or transport sequence, it may include an amino terminal methionine residue. This residue may or may not be subsequently cleaved from the expressed recombinant protein to provide a final product. 
     The term “recombinant expression system” means host cells which have stably integrated a recombinant transcriptional unit into chromosomal DNA or carry the recombinant transcriptional unit extrachromosomally. Recombinant expression systems as defined herein will express heterologous polypeptides or proteins upon induction of the regulatory elements linked to the DNA segment or synthetic gene to be expressed. This term also means host cells which have stably integrated a recombinant genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers. Recombinant expression systems as defined herein will express polypeptides or proteins endogenous to the cell upon induction of the regulatory elements linked to the endogenous DNA segment or gene to be expressed. The cells can be prokaryotic or eukaryotic. 
     The term “secreted” includes a protein that is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence when it is expressed in a suitable host cell. “Secreted” proteins include without limitation proteins secreted wholly (e.g., soluble proteins) or partially (e.g., receptors) from the cell in which they are expressed. “Secreted” proteins also include without limitation proteins that are transported across the membrane of the endoplasmic reticulum. “Secreted” proteins are also intended to include proteins containing non-typical signal sequences (e.g. Interleukin-1 Beta, see Krasney, P. A. and Young, P. R. (1992) Cytokine 4(2):134-143) and factors released from damaged cells (e.g. Interleukin-1 Receptor Antagonist, see Arend, W. P. et. al. (1998) Annu. Rev. Immunol. 16:27-55) 
     Where desired, an expression vector may be designed to contain a “signal or leader sequence” which will direct the polypeptide through the membrane of a cell. Such a sequence may be naturally present on the polypeptides of the present invention or provided from heterologous protein sources by recombinant DNA techniques. 
     The term “stringent” is used to refer to conditions that are commonly understood in the art as stringent. Stringent conditions can include highly stringent conditions (i.e., hybridization to filter-bound DNA in 0.5 M NaHPO 4 , 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C., and washing in 0.1×SSC/0.1% SDS at 68° C.), and moderately stringent conditions (i.e., washing in 0.2×SSC/0.1% SDS at 42° C.). Other exemplary hybridization conditions are described herein in the examples. 
     In instances of hybridization of deoxyoligonucleotides, additional exemplary stringent hybridization conditions include washing in 6×SSC/0.05% sodium pyrophosphate at 37° C. (for 14-base oligonucleotides), 48° C. (for 17-base oligos), 55° C. (for 20-base oligonucleotides), and 60° C. (for 23-base oligonucleotides). 
     As used herein, “substantially equivalent” or “substantially similar” can refer both to nucleotide and amino acid sequences, for example a mutant sequence, that varies from a reference sequence by one or more substitutions, deletions, or additions, the net effect of which does not result in an adverse functional dissimilarity between the reference and subject sequences. Typically, such a substantially equivalent sequence varies from one of those listed herein by no more than about 35% (i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.35 or less). Such a sequence is said to have 65% sequence identity to the listed sequence. In one embodiment, a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 30% (70% sequence identity); in a variation of this embodiment, by no more than 25% (75% sequence identity); and in a further variation of this embodiment, by no more than 20% (80% sequence identity) and in a further variation of this embodiment, by no more than 10% (90% sequence identity) and in a further variation of this embodiment, by no more that 5% (95% sequence identity). Substantially equivalent, e.g., mutant, amino acid sequences according to the invention preferably have at least 80% sequence identity with a listed amino acid sequence, more preferably at least 85% sequence identity, more preferably at least 90% sequence identity, more preferably at least 95% sequence identity, more preferably at least 98% sequence identity, and most preferably at least 99% sequence identity. Substantially equivalent nucleotide sequence of the invention can have lower percent sequence identities, taking into account, for example, the redundancy or degeneracy of the genetic code. Preferably, the nucleotide sequence has at least about 65% identity, more preferably at least about 75% identity, more preferably at least about 80% sequence identity, more preferably at least 85% sequence identity, more preferably at least 90% sequence identity, more preferably at least about 95% sequence identity, more preferably at least 98% sequence identity, and most preferably at least 99% sequence identity. For the purposes of the present invention, sequences having substantially equivalent biological activity and substantially equivalent expression characteristics are considered substantially equivalent. For the purposes of determining equivalence, truncation of the mature sequence (e.g., via a mutation which creates a spurious stop codon) should be disregarded. Sequence identity may be determined, e.g., using the Jotun Hein method (Hein, J. (1990) Methods Enzymol. 183:626-645). Identity between sequences can also be determined by other methods known in the art, e.g. by varying hybridization conditions. 
     The term “totipotent” refers to the capability of a cell to differentiate into all of the cell types of an adult organism. 
     The term “transformation” means introducing DNA into a suitable host cell so that the DNA is replicable, either as an extrachromosomal element, or by chromosomal integration. The term “transfection” refers to the taking up of an expression vector by a suitable host cell, whether or not any coding sequences are in fact expressed. The term “infection” refers to the introduction of nucleic acids into a suitable host cell by use of a virus or viral vector. 
     As used herein, an “uptake modulating fragment,” UMF, means a series of nucleotides which mediate the uptake of a linked DNA fragment into a cell. UMFs can be readily identified using known UMFs as a target sequence or target motif with the computer-based systems described below. The presence and activity of a UMF can be confirmed by attaching the suspected UMF to a marker sequence. The resulting nucleic acid molecule is then incubated with an appropriate host under appropriate conditions and the uptake of the marker sequence is determined. As described above, a UMF will increase the frequency of uptake of a linked marker sequence. 
     Each of the above terms is meant to encompass all that is described for each, unless the context dictates otherwise. 
     3.2 Nucleic Acids of the Invention 
     Nucleotide sequences of the invention are set forth in the Sequence Listing. 
     The isolated polynucleotides of the invention include a polynucleotide comprising the nucleotide sequences of SEQ ID NO: 1-948; a polynucleotide encoding any one of the peptide sequences of SEQ ID NO: 1-948; and a polynucleotide comprising the nucleotide sequence encoding the mature protein coding sequence of the polynucleotides of any one of SEQ ID NO: 1-948. The polynucleotides of the present invention also include, but are not limited to, a polynucleotide that hybridizes under stringent conditions to (a) the complement of any of the nucleotides sequences of SEQ ID NO: 1-948; (b) nucleotide sequences encoding any one of the amino acid sequences set forth in the Sequence Listing; (c) a polynucleotide which is an allelic variant of any polynucleotide recited above; (d) a polynucleotide which encodes a species homolog of any of the proteins recited above; or (c) a polynucleotide that encodes a polypeptide comprising a specific domain or truncation of the polypeptides of SEQ ID NO: 1-948. Domains of interest may depend on the nature of the encoded polypeptide; e.g., domains in receptor-like polypeptides include ligand-binding, extracellular, transmembrane, or cytoplasmic domains, or combinations thereof; domains in immunoglobulin-like proteins include the variable immunoglobulin-like domains; domains in enzyme-like polypeptides include catalytic and substrate binding domains; and domains in ligand polypeptides include receptor-binding domains. 
     The polynucleotides of the invention include naturally occurring or wholly or partially synthetic DNA, e.g., cDNA and genomic DNA, and RNA, e.g., mRNA. The polynucleotides may include all of the coding region of the cDNA or may represent a portion of the coding region of the cDNA. 
     The present invention also provides genes corresponding to the cDNA sequences disclosed herein. The corresponding genes can be isolated in accordance with known methods using the sequence information disclosed herein Such methods include the preparation of probes or primers from the disclosed sequence information for identification and/or amplification of genes in appropriate genomic libraries or other sources of genomic materials. Further 5′ and 3′ sequence can be obtained using methods known in the art. For example, full length cDNA or genomic DNA that corresponds to any of the polynucleotides of SEQ ID NO: 1-948 can be obtained by screening appropriate cDNA or genomic DNA libraries under suitable hybridization conditions using any of the polynucleotides of SEQ ID NO: 1-948 or a portion thereof as a probe. Alternatively, the polynucleotides of SEQ ID NO: 1-948 may be used as the basis for suitable primer(s) that allow identification and/or amplification of genes in appropriate genomic DNA or cDNA libraries. 
     The nucleic acid sequences of the invention can be assembled from ESTs and sequences (including cDNA and genomic sequences) obtained from one or more public databases, such as dbEST, gbpri, and UniGene. The EST sequences can provide identifying sequence information, representative fragment or segment information, or novel segment information for the full-length gene. 
     The polynucleotides of the invention also provide polynucleotides including nucleotide sequences that are substantially equivalent to the polynucleotides recited above. Polynucleotides according to the invention can have, e.g., at least about 65%, at least about 70%, at least about 75%, at least about 80%, 81%, 82%, 83%, 84%, more typically at least about 85%, 86%, 87%, 88%, 89%, more typically at least about 90%, 91%, 92%, 93%, 94%, and even more typically at least about 95%, 96%, 97%, 98%, 99% sequence identity to a polynucleotide recited above. 
     Included within the scope of the nucleic acid sequences of the invention are nucleic acid sequence fragments that hybridize under stringent conditions to any of the nucleotide sequences of SEQ ID NO: 1-948, or complements thereof, which fragment is greater than about 5 nucleotides, preferably 7 nucleotides, more preferably greater than 9 nucleotides and most preferably greater than 17 nucleotides. Fragments of, e.g. 15, 17, or 20 nucleotides or more that are selective for (i.e. specifically hybridize to any one of the polynucleotides of the invention) are contemplated. Probes capable of specifically hybridizing to a polynucleotide can differentiate polynucleotide sequences of the invention from other polynucleotide sequences in the same family of genes or can differentiate human genes from genes of other species, and are preferably based on unique nucleotide sequences. 
     The sequences falling within the scope of the present invention are not limited to these specific sequences, but also include allelic and species variations thereof. Allelic and species variations can be routinely determined by comparing the sequence provided in SEQ ID NO: 1-948, a representative fragment thereof, or a nucleotide sequence at least 90% identical, preferably 95% identical, to SEQ ID NOs: 1-948 with a sequence from another isolate of the same species. Furthermore, to accommodate codon variability, the invention includes nucleic acid molecules coding for the same amino acid sequences as do the specific ORFs disclosed herein. In other words, in the coding region of an ORF, substitution of one codon for another codon that encodes the same amino acid is expressly contemplated. 
     The nearest neighbor or homology result for the nucleic acids of the present invention, including SEQ ID NOs: 1-948, can be obtained by searching a database using an algorithm or a program. Preferably, a BLAST which stands for Basic Local Alignment Search Tool is used to search for local sequence alignments (Altshul, S. F. J Mol. Evol. 36 290-300 (1993) and Altschul S. F. et al. J. Mol. Biol. 21:403-410 (1990)). Alternatively a FASTA version 3 search against Genpept, using Fastxy algorithm. 
     Species homologs (or orthologs) of the disclosed polynucleotides and proteins are also provided by the present invention. Species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from the desired species. 
     The invention also encompasses allelic variants of the disclosed polynucleotides or proteins; that is, naturally-occurring alternative forms of the isolated polynucleotide which also encode proteins which are identical, homologous or related to that encoded by the polynucleotides. 
     The nucleic acid sequences of the invention are further directed to sequences which encode variants of the described nucleic acids. These amino acid sequence variants may be prepared by methods known in the art by introducing appropriate nucleotide changes into a native or variant polynucleotide. There are two variables in the construction of amino acid sequence variants: the location of the mutation and the nature of the mutation. Nucleic acids encoding the amino acid sequence variants are preferably constructed by mutating the polynucleotide to encode an amino acid sequence that does not occur in nature. These nucleic acid alterations can be made at sites that differ in the nucleic acids from different species (variable positions) or in highly conserved regions (constant regions). Sites at such locations will typically be modified in series, e.g., by substituting first with conservative choices (e.g., hydrophobic amino acid to a different hydrophobic amino acid) and then with more distant choices (e.g., hydrophobic amino acid to a charged amino acid), and then deletions or insertions may be made at the target site. Amino acid sequence deletions generally range from about 1 to 30 residues, preferably about 1 to 10 residues, and are typically contiguous. Amino acid insertions include amino- and/or carboxyl-terminal fusions ranging in length from one to one hundred or more residues, as well as intrasequence insertions of single or multiple amino acid residues. Intrasequence insertions may range generally from about 1 to 10 amino residues, preferably from 1 to 5 residues. Examples of terminal insertions include the heterologous signal sequences necessary for secretion or for intracellular targeting in different host cells and sequences such as FLAG or poly-histidine sequences useful for purifying the expressed protein. 
     In a preferred method, polynucleotides encoding the novel amino acid sequences are changed via site-directed mutagenesis. This method uses oligonucleotide sequences to alter a polynucleotide to encode the desired amino acid variant, as well as sufficient adjacent nucleotides on both sides of the changed amino acid to form a stable duplex on either side of the site of being changed. In general, the techniques of site-directed mutagenesis are well known to those of skill in the art and this technique is exemplified by publications such as, Edelman et al.,  DNA  2:183 (1983). A versatile and efficient method for producing site-specific changes in a polynucleotide sequence was published by Zoller and Smith,  Nucleic Acids Res . 10:6487-6500 (1982). PCR may also be used to create amino acid sequence variants of the novel nucleic acids. When small amounts of template DNA are used as starting material, primer(s) that differs slightly in sequence from the corresponding region in the template DNA can generate the desired amino acid variant. PCR amplification results in a population of product DNA fragments that differ from the polynucleotide template encoding the polypeptide at the position specified by the primer. The product DNA fragments replace the corresponding region in the plasmid and this gives a polynucleotide encoding the desired amino acid variant. 
     A further technique for generating amino acid variants is the cassette mutagenesis technique described in Wells et al.,  Gene  34:315 (1985); and other mutagenesis techniques well known in the art, such as, for example, the techniques in Sambrook et al., supra, and  Current Protocols in Molecular Biology , Ausubel et al. Due to the inherent degeneracy of the genetic code, other DNA sequences which encode substantially the same or a functionally equivalent amino acid sequence may be used in the practice of the invention for the cloning and expression of these novel nucleic acids. Such DNA sequences include those which are capable of hybridizing to the appropriate novel nucleic acid sequence under stringent conditions. 
     Polynucleotides encoding preferred polypeptide truncations of the invention can be used to generate polynucleotides encoding chimeric or fusion proteins comprising one or more domains of the invention and heterologous protein sequences. 
     The polynucleotides of the invention additionally include the complement of any of the polynucleotides recited above. The polynucleotide can be DNA (genomic, cDNA, amplified, or synthetic) or RNA. Methods and algorithms for obtaining such polynucleotides are well known to those of skill in the art and can include, for example, methods for determining hybridization conditions that can routinely isolate polynucleotides of the desired sequence identities. 
     In accordance with the invention, polynucleotide sequences comprising the mature protein coding sequences corresponding to any one of SEQ ID NO: 1-948, or functional equivalents thereof, may be used to generate recombinant DNA molecules that direct the expression of that nucleic acid, or a functional equivalent thereof, in appropriate host cells. Also included are the cDNA inserts of any of the clones identified herein. 
     A polynucleotide according to the invention can be joined to any of a variety of other nucleotide sequences by well-established recombinant DNA techniques (see Sambrook J et al. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY). Useful nucleotide sequences for joining to polynucleotides include an assortment of vectors, e.g., plasmids, cosmids, lambda phage derivatives, phagemids, and the like, that are well known in the art. Accordingly, the invention also provides a vector including a polynucleotide of the invention and a host cell containing the polynucleotide. In general, the vector contains an origin of replication functional in at least one organism, convenient restriction endonuclease sites, and a selectable marker for the host cell. Vectors according to the invention include expression vectors, replication-vectors, probe generation vectors, and sequencing vectors. A host cell according to the invention can be a prokaryotic or eukaryotic cell and can be a unicellular organism or part of a multicellular organism. 
     The present invention further provides recombinant constructs comprising a nucleic acid having any of the nucleotide sequences of SEQ ID NOs: 1-948 or a fragment thereof or any other polynucleotides of the invention. In one embodiment, the recombinant constructs of the present invention comprise a vector, such as a plasmid or viral vector, into which a nucleic acid having any of the nucleotide sequences of SEQ ID NOs: 1-948 or a fragment thereof is inserted, in a forward or reverse orientation. In the case of a vector comprising one of the ORFs of the present invention, the vector may further comprise regulatory sequences, including for example, a promoter, operably linked to the ORF. Large numbers of suitable vectors and promoters are known to those of skill in the art and are commercially available for generating the recombinant constructs of the present invention. The following vectors are provided by way of example. Bacterial: pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene); pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia). Eukaryotic: pWLneo, pSV2cat, pOG44, PXTI, pSG (Stratagene) pSVK3, pBPV, pMSG, pSVL (Pharmacia). 
     The isolated polynucleotide of the invention may be operably linked to an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufmnan et al.,  Nucleic Acids Res . 19, 4485-4490 (1991), in order to produce the protein recombinantly. Many suitable expression control sequences are known in the art. General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman,  Methods in Enzymology  185, 537-566 (1990). As defined herein “operably linked” means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/expression control sequence. 
     Promoter regions can be selected from any desired gene using CAT (chloramphenicol transferase) vectors or other vectors with selectable markers. Two appropriate vectors are pKK232-8 and pCM7. Particular named bacterial promoters include lac, lacZ, T3, T7, gpt, lambda PR, and trc. Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, LTRs from retrovirus, and mouse metallothionein-I. Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art. Generally, recombinant expression vectors will include origins of replication and selectable markers permitting transformation of the host cell, e.g., the ampicillin resistance gene of  E. coli  and  S. cerevisiae  TRP 1 gene, and a promoter derived from a highly-expressed gene to direct transcription of a downstream structural sequence. Such promoters can be derived from operons encoding glycolytic enzymes such as 3-phosphoglycerate kinase (PGK), a-factor, acid phosphatase, or heat shock proteins, among others. The heterologous structural sequence is assembled in appropriate phase with translation initiation and termination sequences, and preferably, a leader sequence capable of directing secretion of translated protein into the periplasmic space or extracellular medium. Optionally, the heterologous sequence can encode a fusion protein including an amino terminal identification peptide imparting desired characteristics, e.g., stabilization or simplified purification of expressed recombinant product. Useful expression vectors for bacterial use are constructed by inserting a structural DNA sequence encoding a desired protein together with suitable translation initiation and termination signals in operable reading phase with a functional promoter. The vector will comprise one or more phenotypic selectable markers and an origin of replication to ensure maintenance of the vector and to, if desirable, provide amplification within the host. Suitable prokaryotic hosts for transformation include  E. coli, Bacillus subtilis, Salmonella typhimurium  and various species within the genera Pseudomonas, Streptomyces, and Staphylococcus, although others may also be employed as a matter of choice. 
     As a representative but non-limiting example, usefull expression vectors for bacterial use can comprise a selectable marker and bacterial origin of replication derived from commercially available plasmids comprising genetic elements of the well known cloning vector pBR322 (ATCC 37017). Such commercial vectors include, for example, pKK223-3 (Pharmacia Fine Chemicals, Uppsala, Sweden) and GEM 1 (Promega Biotech, Madison, Wis., USA). These pBR322 “backbone” sections are combined with an appropriate promoter and the structural sequence to be expressed. Following transformation of a suitable host strain and growth of the host strain to an appropriate cell density, the selected promoter is induced or derepressed by appropriate means (e.g., temperature shift or chemical induction) and cells are cultured for an additional period. Cells are typically harvested by centrimugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification. 
     Polynucleotides of the invention can also be used to induce immune responses. For example, as described in Fan et al.,  Nat. Biotech . 17:870-872 (1999), incorporated herein by reference, nucleic acid sequences encoding a polypeptide may be used to generate antibodies against the encoded polypeptide following topical administration of naked plasmid DNA or following injection, and preferably intra-muscular injection of the DNA. The nucleic acid sequences are preferably inserted in a recombinant expression vector and may be in the form of naked DNA. 
     3.3 Antisense 
     Another aspect of the invention pertains to isolated antisense nucleic acid molecules that are hybridizable to or complementary to the nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 1-948, or fragments, analogs or derivatives thereof. An “antisense” nucleic acid comprises a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire coding strand, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of a protein of any of SEQ ID NO: 1-948 or antisense nucleic acids complementary to a nucleic acid sequence of SEQ ID NO: 1-948 are additionally provided. 
     In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence of the invention. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues. In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence of the invention. The term “noncoding region” refers to 5′ and 3′ sequences that flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions). 
     Given the coding strand sequences encoding a nucleic acid disclosed herein (e.g., SEQ ID NO: 1-948, antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of an mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of an mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of an mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleicacid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. 
     Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl)uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection). 
     The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a protein according to the invention to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens. The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred. 
     In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual α-units, the strands run parallel to each other (Gaultier et al. (1987)  Nucleic Acids Res  15: 6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987)  Nucleic Acids Res  15: 6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1 987)  FEBS Lett  215: 327-330). 
     3.4 Ribozymes and PNA Moieties 
     In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988)  Nature  334:585-591)) can be used to catalytically cleave mRNA transcripts to thereby inhibit translation of an mRNA. A ribozyme having specificity for a nucleic acid of the invention can be designed based upon the nucleotide sequence of a DNA disclosed herein (ie., SEQ ID NO: 1-948). For example, a derivative of Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a SECX-encoding mRNA. See, e.g., Cech et al. U.S. Pat. No. 4,987,071; and Cech et al. U.S. Pat. No. 5,116,742. Alternatively, SECX mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993)  Science  261:1411-1418. 
     Alternatively, gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region (e.g., promoter and/or enhancers) to form triple helical structures that prevent transcription of the gene in target cells. See generally, Helene. (1991)  Anticancer Drug Des . 6: 569-84; Helene. et al. (1992)  Ann. N.Y. Acad. Sci . 660:27-36; and Maher (1992)  Bioassays  14: 807-15. 
     In various embodiments, the nucleic acids of the invention can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids (see Hyrup et al. (1996)  Bioorg Med Chem  4: 5-23). As used herein, the terms “peptide nucleic acids” or “PNAs” refer to nucleic acid mimics, e.g., DNA mimics, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described in Hyrup et al. (1996) above; Perry-O&#39;Keefe et al. (1996)  PNAS  93: 14670-675. 
     PNAs of the invention can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of the invention can also be used, e.g., in the analysis of single base pair mutations in a gene by, e.g., PNA directed PCR clamping; as artificial irestriction enzymes when used in combination with other enzymes, e.g., S1 nucleases (Hyrup B. (1996) above); or as probes or primers for DNA sequence and hybridization (Hyrup et al. (1996), above; Perry-O&#39;Keefe (1996), above). 
     In another embodiment, PNAs of the invention can be modified, e.g., to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA-DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in the art. For example, PNA-DNA chimeras can be generated that may combine the advantageous properties of PNA and DNA. Such chimeras allow DNA recognition enzymes, e.g., RNase H and DNA polymerases, to interact with the DNA portion while the PNA portion would provide high binding affinity and specificity. PNA-DNA chimeras can be linked using linkers of appropriate lengths selected in terms of base stacking, number of bonds between the nucleobases, and orientation (Hyrup (1996) above). The synthesis of PNA-DNA chimeras can be performed as described in Hyrup (1996) above and Finn et al. (1996)  Nucl Acids Res  24: 3357-63. For example, a DNA chain can be synthesized on a solid support using standard phosphoramidite coupling chemistry, and modified nucleoside analogs, e.g., 5′(4-methoxytrityl)amino-5′-deoxy-thymidine phosphoramidite, can be used between the PNA and the 5′ end of DNA (Mag et al. (1989)  Nucl Acid Res  17: 5973-88). PNA monomers are then coupled in a stepwise manner to produce a chimeric molecule with a 5′ PNA segment and a 3′ DNA segment (Finn et al. (1996) above). Alternatively, chimeric molecules can be synthesized with a 5′ DNA segment and a 3′ PNA segment. See, Petersen et al. (1975)  Bioorg Med Chem Lett  5: 1119-11124. 
     In other embodiments, the oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger et al., 1989 , Proc. Natl. Acad. Sci. U.S.A . 86:6553-6556; Lemaitre et al., 1987, Proc. Natl.  Acad. Sci . 84:648-652; PCT Publication No. W088/09810) or the blood-brain barrier (see, e.g., PCT Publication No. W089/10134). In addition, oligonucleotides can be modified with hybridization triggered cleavage agents (See, e.g., Krol et al., 1988 , BioTechniques  6:958-976) or intercalating agents. (See, e.g., Zon, 1988 , Pharm. Res . 5: 539-549). To this end, the oligonucleotide may be conjugated to another molecule, e.g., a peptide, a hybridization triggered cross-linking agent, a transport agent, a hybridization-triggered cleavage agent, etc. 
     3.5 Hosts 
     The present invention further provides host cells genetically engineered to contain the polynucleotides of the invention. For example, such host cells may contain nucleic acids of the invention introduced into the host cell using known transformation, transfection or infection methods. The present invention still further provides host cells genetically engineered to express the polynucleotides of the invention, wherein such polynucleotides are in operative association with a regulatory sequence heterologous to the host cell which drives expression of the polynucleotides in the cell. 
     Knowledge of nucleic acid sequences allows for modification of cells to permit, or increase, expression of endogenous polypeptide. Cells can be modified (e.g., by homologous recombination) to provide increased polypeptide expression by replacing, in whole or in part, the naturally occurring promoter with all or part of a heterologous promoter so that the cells express the polypeptide at higher levels. The heterologous promoter is inserted in such a manner that it is operatively linked to the encoding sequences. See, for example, PCT International Publication No. WO94/12650, PCT International Publication No. WO92/20808, and PCT International Publication No. WO91/09955. It is also contemplated that, in addition to heterologous promoter DNA, amplifiable marker DNA (e.g., ada, dhfr, and the multifunctional CAD gene which encodes carbamyl phosphate synthase, aspartate transcarbamylase, and dihydroorotase) and/or intron DNA may be inserted along with the heterologous promoter DNA. If linked to the coding sequence, amplification of the marker DNA by standard selection methods results in co-amplification of the desired protein coding sequences in the cells. 
     The host cell can be a higher eukaryotic host cell, such as a mammalian cell, a lower eukaryotic host cell, such as a yeast cell, or the host cell can be a prokaryotic cell, such as a bacterial cell. Introduction of the recombinant construct into the host cell can be effected by calcium phosphate transfection, DEAE, dextran mediated transfection, or electroporation Davis, L. et al.,  Basic Methods in Molecular Biology  (1986)). The host cells containing one of the polynucleotides of the invention, can be used in conventional manners to produce the gene product encoded by the isolated fragment (in the case of an ORF) or can be used to produce a heterologous protein under the control of the EMF. 
     Any host/vector system can be used to express one or more of the ORFs of the present invention. These include, but are not limited to, eukaryotic hosts such as HeLa cells, Cv-1 cell, COS cells, 293 cells, and Sf9 cells, as well as prokaryotic host such as  E. coli  and  B. subtilis . The most preferred cells are those which do not normally express the particular polypeptide or protein or which expresses the polypeptide or protein at low natural level. Mature proteins can be expressed in mammalian cells, yeast, bacteria, or other cells under the control of appropriate promoters. Cell-free translation systems can also be employed to produce such proteins using RNAs derived from the DNA constructs of the present invention. Appropriate cloning and expression vectors for use with prokaryotic and eukaryotic hosts are described by Sambrook, et al., in Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, N.Y. (1989), the disclosure of which is hereby incorporated by reference. 
     Various mammalian cell culture systems can also be employed to express recombinant protein. Examples of mammalian expression systems include the COS-7 lines of monkey kidney fibroblasts, described by Gluzman, Cell 23:175 (1981). Other cell lines capable of expressing a compatible vector are, for example, the C127, monkey COS cells, Chinese Hamster Ovary (CHO) cells, human kidney 293 cells, human epidermal A431 cells, human Colo205 cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse L cells, BHK, HL60, U937, HaK or Jurkat cells. Mammalian expression vectors will comprise an origin of replication, a suitable promoter and also any necessary ribosome binding sites, polyadenylation site, splice donor and acceptor sites, transcriptional termination sequences, and 5′ flanking nontranscribed sequences. DNA sequences derived from the SV40 viral genome, for example, SV40 origin, early promoter, enhancer, splice, and polyadenylation sites may be used to provide the required nontranscribed genetic elements. Recombinant polypeptides and proteins produced in bacterial culture are usually isolated by initial extraction from cell pellets, followed by one or more salting-out, aqueous ion exchange or size exclusion chromatography steps. Protein refolding steps can be used, as necessary, in completing configuration of the mature protein. Finally, high performance liquid chromatography (HPLC) can be employed for fmal purification steps. Microbial cells employed in expression of proteins can be disrupted by any convenient method, including freeze-thaw cycling, sonication, mechanical disruption, or use of cell lysing agents. 
     Alternatively, it may be possible to produce the protein in lower eukaryotes such as yeast or insects or in prokaryotes such as bacteria. Potentially suitable yeast strains include  Saccharomyces cerevisiae, Schizosaccharomyces pombe , Kluyveromyces strains, Candida, or any yeast strain capable of expressing heterologous proteins. Potentially suitable bacterial strains include  Escherichia coli, Bacillus subtilis, Salmonella typhimurium , or any bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast or bacteria, it may be necessary to modify the protein produced therein, for example by phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional protein. Such covalent attachments may be accomplished using known chemical or enzymatic methods. 
     In another embodiment of the present invention, cells and tissues may be engineered to express an endogenous gene comprising the polynucleotides of the invention under the control of inducible regulatory elements, in which case the regulatory sequences of the endogenous gene may be replaced by homologous recombination. As described herein, gene targeting can be used to replace a gene&#39;s existing regulatory region with a regulatory sequence isolated from a different gene or a novel regulatory sequence synthesized by genetic engineering methods. Such regulatory sequences may be comprised of promoters, enhancers, scaffold-attachment regions, negative regulatory elements, transcriptional initiation sites, regulatory protein binding sites or combinations of said sequences. Alternatively, sequences which affect the structure or stability of the RNA or protein produced may be replaced, removed, added, or otherwise modified by targeting. These sequence include polyadenylation signals, mRNA stability elements, splice sites, leader sequences for enhancing or modifying transport or secretion properties of the protein, or other sequences which alter or improve the fumction or stability of protein or RNA molecules. 
     The targeting event may be a simple insertion of the regulatory sequence, placing the gene under the control of the new regulatory sequence, e.g., inserting a new promoter or enhancer or both upstream of a gene. Alternatively, the targeting event may be a simple deletion of a regulatory element, such as the deletion of a tissue-specific negative regulatory element. Alternatively, the targeting event may replace an existing element; for example, a tissue-specific enhancer can be replaced by an enhancer that has broader or different cell-type specificity than the naturally occurring elements. Here, the naturally occurring sequences are deleted and new sequences are added. In all cases, the identification of the targeting event may be facilitated by the use of one or more selectable marker genes that are contiguous with the targeting DNA, allowing for the selection of cells in which the exogenous DNA has integrated into the host cell genome. The identification of the targeting event may also be facilitated by the use of one or more marker genes exhibiting the property of negative selection, such that the negatively selectable marker is linked to the exogenous DNA, but configured such that the negatively selectable marker flanks the targeting sequence, and such that a correct homologous recombination event with sequences in the host cell genome does not result in the stable integration of the negatively selectable marker. Markers useful for this purpose include the Herpes Simplex Virus thyrnidine kinase (TK) gene or the bacterial xanthine-guanine phosphoribosyl-transferase (gpt) gene. 
     The gene targeting or gene activation techniques which can be used in accordance with this aspect of the invention are more particularly described in U.S. Pat. No. 5,272,071 to Chappel; U.S. Pat. No. 5,578,461 to Sherwin et al.; International Application No. PCT/US92/09627 (WO93/09222) by Selden et al.; and International Application No. PCT/US90/06436 (WO91/06667) by Skoultchi et al., each of which is incorporated by reference herein in its entirety. 
     3.6 Polypeptides of the Invention 
     The isolated polypeptides of the invention include, but are not limited to, a polypeptide comprising: the amino acid sequences set forth as any one of SEQ ID NO: 1-948 or an amino acid sequence encoded by any one of the nucleotide sequences SEQ ID NOs: 1-948 or the corresponding fulll length or mature protein. Polypeptides of the invention also include polypeptides preferably with biological or immunological activity that are encoded by: (a) a polynucleotide having any one of the nucleotide sequences set forth in SEQ ID NOs: 1-948 or (b) polynucleotides encoding any one of the amino acid sequences set forth as SEQ ID NO: 1-948 or (c) polynucleotides that hybridize to the complement of the polynucleotides of either (a) or (b) under stringent hybridization conditions. The invention also provides biologically active or immunologically active variants of any of the amino acid sequences set forth as SEQ ID NO: 1-948 or the corresponding full length or mature protein; and “substantial equivalents” thereof (e.g., with at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, 86%, 87%, 88%, 89%, at least about 90%, 91%, 92%, 93%, 94%, typically at least about 95%, 96%, 97%, more typically at least about 98%, or most typically at least about 99% amino acid identity) that retain biological activity. Polypeptides encoded by allelic variants may have a similar, increased, or decreased activity compared to polypeptides comprising SEQ ID NO: 1-948. 
     Fragments of the proteins of the present invention which are capable of exhibiting biological activity are also encompassed by the present invention. Fragments of the protein may be in linear form or they may be cyclized using known methods, for example, as described in H. U. Saragovi, et al., Bio/Technology 10, 773-778 (1992) and in R. S. McDowell, et al., J. Amer. Chem. Soc. 114, 9245-9253 (1992), both of which are incorporated herein by reference. Such fragments may be fused to carrier molecules such as immunoglobulins for many purposes, including increasing the valency of protein binding sites. 
     The present invention also provides both full-length and mature forms (for example, without a signal sequence or precursor sequence) of the disclosed proteins. The protein coding sequence is identified in the sequence listing by translation of the disclosed nucleotide sequences. The mature form of such protein may be obtained by expression of a full-length polynuclcotide in a suitable mammalian cell or other host cell. The sequence of the mature form of the protein is also determinable from the amino acid sequence of the full-length form. Where proteins of the present invention are membrane bound, soluble forms of the proteins are also provided. In such forms, part or all of the regions causing the proteins to be membrane bound are deleted so that the proteins are fully secreted from the cell in which they are expressed. 
     Protein compositions of the present invention may further comprise an acceptable carrier, such as a hydrophilic, e.g., pharmaceutically acceptable, carrier. 
     The present invention further provides isolated polypeptides encoded by the nucleic acid fragments of the present invention or by degenerate variants of the nucleic acid fragments of the present invention. By “degenerate variant” is intended nucleotide fragments which differ from a nucleic acid fragment of the present invention (e.g., an ORF) by nucleotide sequence but, due to the degeneracy of the genetic code, encode an identical polypeptide sequence. Preferred nucleic acid fragments of the present invention are the ORFs that encode proteins. 
     A variety of methodologies kcnown in the art can be utilized to obtain any one of the isolated polypeptides or proteins of the present invention. At the simplest level, the amino acid sequence can be synthesized using commercially available peptide synthesizers. The synthetically-constructed protein sequences, by virtue of sharing primary, secondary or tertiary structural and/or conformational characteristics with proteins may possess biological properties in common therewith, including protein activity. This technique is particularly useful in producing small peptides and fragments of larger polypeptides. Fragments are useful, for example, in generating antibodies against the native polypeptide. Thus, they may be employed as biologically active or immunological substitutes for natural, purified proteins in screening of therapeutic compounds and in immunological processes for the development of antibodies. 
     The polypeptides and proteins of the present invention can alternatively be purified from cells which have been altered to express the desired polypeptide or protein. As used herein, a cell is said to be altered to express a desired polypeptide or protein when the cell, through genetic manipulation, is made to produce a polypeptide or protein which it normally does not produce or which the cell normally produces at a lower level. One skilled in the art can readily adapt procedures for introducing and expressing either recombinant or synthetic sequences into eukaryotic or prokaryotic cells in order to generate a cell which produces one of the polypeptides or proteins of the present invention. 
     The invention also relates to methods for producing a polypeptide comprising growing a culture of host cells of the invention in a suitable culture medium, and purifying the protein from the cells or the culture in which the cells are grown. For example, the methods of the invention include a process for producing a polypeptide in which a host cell containing a suitable expression vector that includes a polynucleotide of the invention is cultured under conditions that allow expression of the encoded polypeptide. The polypeptide can be recovered from the culture, conveniently from the culture medium, or from a lysate prepared from the host cells and further purified. Preferred embodiments include those in which the protein produced by such process is a full length or mature form of the protein. 
     In an alternative method, the polypeptide or protein is purified from bacterial cells which naturally produce the polypeptide or protein. One skilled in the art can readily follow known methods for isolating polypeptides and proteins in order to obtain one of the isolated polypeptides or proteins of the present invention. These include, but are not limited to, immunochromatography, HPLC, size-exclusion chromatography, ion-exchange chromatography, and immuno-affinity chromatography. See, e.g., Scopes,  Protein Purification: Principles and Practice , Springer-Verlag (1994); Sambrook, et al., in Molecular Cloning:  A Laboratory Manual ; Ausubel et al.,  Current Protocols in Molecular Biology . Polypeptide fragments that retain biological/immnunological activity include fragments comprising greater than about 100 amino acids, or greater than about 200 amino acids, and fragments that encode specific protein domains. 
     The purified polypeptides can be used in in vitro binding assays which are well known in the art to identify molecules which bind to the polypeptides. These molecules include but are not limited to, for e.g., small molecules, molecules from combinatorial libraries, antibodies or other proteins. The molecules identified in the binding assay are then tested for antagonist or agonist activity in in vivo tissue culture or animal models that are well known in the art. In brief, the molecules are titrated into a plurality of cell cultures or animals and then tested for either cell/animal death or prolonged survival of the animal/cells. 
     In addition, the peptides of the invention or molecules capable of binding to the peptides may be complexed with toxins, e.g., ricin or cholera, or with other compounds that are toxic to cells. The toxin-binding molecule complex is then targeted to a tumor or other cell by the specificity of the binding molecule for SEQ ID NO: 1-948. 
     The protein of the invention may also be expressed as a product of transgenic animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which are characterized by somatic or germ cells containing a nucleotide sequence encoding the protein. 
     The proteins provided herein also include proteins characterized by amino acid sequences similar to those of purified proteins but into which modification are naturally provided or deliberately engineered. For example, modifications, in the peptide or DNA sequence, can be made by those skilled in the art using known techniques. Modifications of interest in the protein sequences may include the alteration, substitution, replacement, insertion or deletion of a selected amino acid residue in the coding sequence. For example, one or more of the cysteine residues may be deleted or replaced with another amino acid to alter the conformation of the molecule. Techniques for such alteration, substitution, replacement, insertion or deletion are well known to those skilled in the art (see, e.g., U.S. Pat. No. 4,518,584). Preferably, such alteration, substitution, replacement, insertion or deletion retains the desired activity of the protein. Regions of the protein that are important for the protein function can be determined by various methods known in the art including the alanine-scanning method which involved systematic substitution of single or strings of amino acids with alanine, followed by testing the resulting alanine-containing variant for biological activity. This type of analysis determines the importance of the substituted amino acid(s) in biological activity. Regions of the protein that are important for protein function may be determined by the eMATRIX program. 
     Other fragments and derivatives of the sequences of proteins which would be expected to retain protein activity in whole or in part and are useful for screening or other immunological methodologies may also be easily made by those skilled in the art given the disclosures herein. Such modifications are encompassed by the present invention. 
     The protein may also be produced by operably linking the isolated polynucleotide of the invention to suitable control sequences in one or more insect expression vectors, and employing an insect expression system. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, e.g., Invitrogen, San Diego, Calif., U.S.A. (the MaxBa™ kit), and such methods are well known in the art, as described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No. 1555 (1987), incorporated herein by reference. As used herein, an insect cell capable of expressing a polynucleotide of the present invention is “transformed.” 
     The protein of the invention may be prepared by culturing transformed host cells under culture conditions suitable to express the recombinant protein. The resulting expressed protein may then be purified from such culture (i.e., from culture medium or cell extracts) using known purification processes, such as gel filtration and ion exchange chromatography. The purification of the protein may also include an affinity column containing agents which will bind to the protein; one or more column steps over such affinity resins as concanavalin A-agarose, heparin-toyopearl™ or Cibacrom blue 3GA Sepharose™; one or more steps involving hydrophobic interaction chromatography using such resins as phenyl ether, butyl ether, or propyl ether; or immunoaffinity chromatography. 
     Alternatively, the protein of the invention may also be expressed in a form which will facilitate purification. For example, it may be expressed as a fulsion protein, such as those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin (TRX), or as a His tag. Kits for expression and purification of such fusion proteins are commercially available from New England BioLab (Beverly, Mass.), Pharmacia (Piscataway, N.J.) and Invitrogen, respectively. The protein can also be tagged with an epitope and subsequently purified by using a specific antibody directed to such epitope. One such epitope (“FLAG®”) is commercially available from Kodak (New Haven, Conn.). 
     Finally, one or more reverse-phase high performance liquid chromatography (RP-BPLC) steps employing hydrophobic RP-HPLC media, e.g. silica gel having pendant methyl or other aliphatic groups, can be employed to further purify the protein. Some or all of the foregoing purification steps, in various combinations, can also be employed to provide a substantially homogeneous isolated recombinant protein. The protein thus purified is substantially free of other mammalian proteins and is defined in accordance with the present invention as an “isolated protein.” 
     The polypeptides of the invention include analogs (variants). This embraces fragments, as well as peptides in which one or more amino acids has been deleted, inserted, or substituted. Also, analogs of the polypeptides of the invention embrace fusions of the polypeptides or modifications of the polypeptides of the invention, wherein the polypeptide or analog is fused to another moiety or moieties, e.g., targeting moiety or another therapeutic agent. Such analogs may exhibit improved properties such as activity and/or stability. Examples of moieties which may be fused to the polypeptide or an analog include, for example, targeting moieties which provide for the delivery of polypeptide to pancreatic cells, e.g., antibodies to pancreatic cells, antibodies to immune cells such as T-cells, monocytes, dendritic cells, granulocytes, etc., as well as receptor and ligands expressed on pancreatic or immune cells. Other moieties which may be fused to the polypeptide include therapeutic agents which are used for treatment, for example, immunosuppressive drugs such as cyclosporin, SK506, azathioprine, CD3 antibodies and steroids. Also, polypeptides may be fused to immune modulators, and other cytokines such as alpha or beta interferon. 
     3.6.1 Determining Polypeptide and Polynucleotide Identity and Similarity 
     Preferred identity and/or similarity are designed to give the largest match between the sequences tested. Methods to determine identity and similarity are codified in computer programs including, but are not limited to, the GCG program package, including GAP (Devereux, J., et al., Nucleic Acids Research 12(1):387 (1984); Genetics Computer Group, University of Wisconsin, Madison, Wis.), BLASTP, BLASTN, BLASTX, FASTA (Altschul, S. F. et al., J. Molec. Biol. 215:403-410 (1990), PSI-BLAST (Altschul S. F. et al., Nucleic Acids Res. vol. 25, pp. 3389-3402, herein incorporated by reference), eMatrix software (Wu et al., J. Comp. Biol., Vol. 6, pp. 219-235 (1999), herein incorporated by reference), eMotif software (Nevill-Manning et al, ISMB-97, Vol. 4, pp. 202-209, herein incorporated by reference), pFam software (Sornhammer et al., Nucleic Acids Res., Vol. 26(1), pp. 320-322 (1998), herein incorporated by reference) and the Kyte-Doolittle hydrophobocity prediction algorithm (J. Mol Biol, 157, pp. 105-31 (1982), incorporated herein by reference). The BLAST programs are publicly available from the National Center for Biotechnology Information (NCBI) and other sources (BLAST Manual, Altschul, S., et al. NCB NLM NIH Bethesda, Md. 20894; Altschul, S., et al., J. Mol. Biol. 215:403-410 (1990). 
     3.7 Chimeric and Fusion Proteins 
     The invention also provides chimeric or fusion proteins. As used herein, a “chimeric protein” or “fusion protein” comprises a polypeptide of the invention operatively linked to another polypeptide. Within a fusion protein the polypeptide according to the invention can correspond to all or a portion of a protein according to the invention. In one embodiment, a fusion protein comprises at least one biologically active portion of a protein according to the invention. In another embodiment, a fusion protein comprises at least two biologically active portions of a protein according to the invention. Within the fusion protein, the term “operatively linked” is intended to indicate that the polypeptide according to the invention and the other polypeptide are fused in-frame to each other. The polypeptide can be fused to the N-terminus or C-terminus, or to the middle. 
     For example, in one embodiment a fusion protein comprises a polypeptide according to the invention operably linked to the extracellular domain of a second protein. 
     In another embodiment, the fusion protein is a GST-fusion protein in which the polypeptide sequences of the invention are fused to the C-terminus of the GST (i.e., glutathione S-transferase) sequences. 
     In another embodiment, the fusion protein is an immunoglobulin fusion protein in which the polypeptide sequences according to the invention comprise one or more domains fused to sequences derived from a member of the immunoglobulin protein family. The immnunoglobulin fusion proteins of the invention can be incorporated into pharmaceutical compositions and administered to a subject to inhibit an interaction between a ligand and a protein of the invention on the surface of a cell, to thereby suppress signal transduction in vivo. The immunoglobulin fusion proteins can be used to affect the bioavailability of a cognate ligand. Inhibition of the ligand/protein interaction may be useful therapeutically for both the treatment of proliferative and differentiative disorders, e.g., cancer as well as modulating (e.g., promoting or inhibiting) cell survival. Moreover, the immunoglobulin fusion proteins of the invention can be used as immunogens to produce antibodies in a subject, to purify ligands, and in screening assays to identify molecules that inhibit the interaction of a polypeptide of the invention with a ligand. 
     A chimeric or fiusion protein of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Ausubel et al. (eds.) C URRENT  P ROTOCOLS IN  M OLECULAR  B IOLOGY , John Wiley &amp; Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A nucleic acid encoding a polypeptide of the invention can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the protein of the invention. 
     3.8 Gene Therapy 
     Mutations in the polynucleotides of the invention gene may result in loss of normal function of the encoded protein. The invention thus provides gene therapy to restore normal activity of the polypeptides of the invention; or to treat disease states involving polypeptides of the invention. Delivery of a functional gene encoding polypeptides of the invention to appropriate cells is effected ex vivo, in situ, or in vivo by use of vectors, and more particularly viral vectors (e.g., adenovirus, adeno-associated virus, or a retrovirus), or ex vivo by use of physical DNA transfer methods (e.g., liposomes or chemical treatments). See, for example, Anderson, Nature, supplement to vol. 392, no. 6679, pp.25-20 (1998). For additional reviews of gene therapy technology see Friedmann, Science, 244: 1275-1281 (1989); Verma, Scientific American: 68-84 (1990); and Miller, Nature, 357: 455460(1992). Introduction of any one of the nucleotides of the present invention or a gene encoding the polypeptides of the present invention can also be accomplished with extrachromosomal substrates (transient expression) or artificial chromosomes (stable expression). Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic purposes. Alternatively, it is contemplated that in other human disease states, preventing the expression of or inhibiting the activity of polypeptides of the invention will be useful in treating the disease states. It is contemplated that antisense therapy or gene therapy could be applied to negatively regulate the expression of polypeptides of the invention. 
     Other methods inhibiting expression of a protein include the introduction of antisense molecules to the nucleic acids of the present invention, their complements, or their translated RNA sequences, by methods known in the art. Further, the polypeptides of the present invention can be inhibited by using targeted deletion methods, or the insertion of a negative regulatory element such as a silencer, which is tissue specific. 
     The present invention still further provides cells genetically engineered in vivo to express the polynucleotides of the invention, wherein such polynucleotides are in operative association with a regulatory sequence heterologous to the host cell which drives expression of the polynucleotides in the cell. These methods can be used to increase or decrease the expression of the polynucleotides of the present invention. 
     Knowledge of DNA sequences provided by the invention allows for modification of cells to permit, increase, or decrease, expression of endogenous polypeptide. Cells can be modified (e.g., by homologous recombination) to provide increased polypeptide expression by replacing, in whole or in part, the naturally occurring promoter with all or part of a heterologous promoter so that the cells express the protein at higher levels. The heterologous promoter is inserted in such a manner that it is operatively linked to the desired protein encoding sequences. See, for example, PCT International Publication No. WO 94/12650, PCT International Publication No. WO 92/20808, and PCT International Publication No. WO 91/09955. It is also contemplated that, in addition to heterologous promoter DNA, amplifiable marker DNA (e.g., ada, dhfr, and the multifunctional CAD gene which encodes carbamyl phosphate synthase, aspartate transcarbamylase, and dihydroorotase) and/or intron DNA may be inserted along with the heterologous promoter DNA. If linked to the desired protein coding sequence, amplification of the marker DNA by standard selection methods results in co-amplification of the desired protein coding sequences in the cells. 
     In another embodiment of the present invention, cells and tissues may be engineered to express an endogenous gene comprising the polynucleotides of the invention under the control of inducible regulatory elements, in which case the regulatory sequences of the endogenous gene may be replaced by homologous recombination. As described herein, gene targeting can be used to replace a gene&#39;s existing regulatory region with a regulatory sequence isolated from a different gene or a novel regulatory sequence synthesized by genetic engineering methods. Such regulatory sequences may be comprised of promoters, enhancers, scaffold-attachment regions, negative regulatory elements, transcriptional initiation sites, regulatory protein binding sites or combinations of said sequences. Alternatively, sequences which affect the structure or stability of the RNA or protein produced may be replaced, removed, added, or otherwise modified by targeting. These sequences include polyadenylation signals, mRNA stability elements, splice sites, leader sequences for enhancing or modifying transport or secretion properties of the protein, or other sequences which alter or improve the function or stability of protein or RNA molecules. 
     The targeting event may be a simple insertion of the regulatory sequence, placing the gene under the control of the new regulatory sequence, e.g., inserting a new promoter or enhancer or both upstream of a gene. Alternatively, the targeting event may be a simple deletion of a regulatory element, such as the deletion of a tissue-specific negative regulatory element. Alternatively, the targeting event may replace an existing element; for example, a tissue-specific enhancer can be replaced by an enhancer that has broader or different cell-type specificity than the naturally occurring elements. Here, the naturally occurring sequences are deleted and new sequences are added. In all cases, the identification of the targeting event may be facilitated by the use of one or more selectable marker genes that are contiguous with the targeting DNA, allowing for the selection of cells in which the exogenous DNA has integrated into the cell genome. The identification of the targeting event may also be facilitated by the use of one or more marker gencs exhibiting the property of negative selection, such that the negatively selectable marker is linked to the exogenous DNA, but configured such that the negatively selectable marker flanks the targeting sequence, and such that a correct homologous recombination event with sequences in the host cell genome does not result in the stable integration of the negatively selectable marker. Markers useful for this purpose include the Herpes Simplex Virus thyrnidine kinase (TK) gene or the bacterial xanthine-guanine phosphoribosyl-transferase (gpt) gene. 
     The gene targeting or gene activation techniques which can be used in accordance with this aspect of the invention are more particularly described in U.S. Pat. No. 5,272,071 to Chappel; U.S. Pat. No. 5,578,461 to Sherwin et al.; International Application No. PCT/US92/09627 (WO93/09222) by Selden et al.; and International Application No. PCT/US90/06436 (WO91/06667) by Skoultchi et al., each of which is incorporated by reference herein in its entirety. 
     3.9 Transgenic Animals 
     In preferred methods to determine biological functions of the polypeptides of the invention in vivo, one or more genes provided by the invention are either over expressed or inactivated in the germ line of animals using homologous recombination [Capecchi, Science 244:1288-1292 (1989)]. Animals in which the gene is over expressed, under the regulatory control of exogenous or endogenous promoter elements, are known as transgenic animals. Animals in which an endogenous gene has been inactivated by homologous recombination are referred to as “knockout” animals. Knockout animals, preferably non-human mammals, can be prepared as described in U.S. Pat. No. 5,557,032, incorporated herein by reference. Transgenic animals are useful to determine the roles polypeptides of the invention play in biological processes, and preferably in disease states. Transgenic animals are useful as model systems to identify compounds that modulate lipid metabolism. Transgenic animals, preferably non-human mammals, are produced using methods as described in U.S. Pat. No. 5,489,743 and PCT Publication No. WO94/28122, incorporated herein by reference. 
     Transgenic animals can be prepared wherein all or part of a promoter of the polynucleotides of the invention is either activated or inactivated to alter the level of expression of the polypeptides of the invention. Inactivation can be carried out using homologous recombination methods described above. Activation can be achieved by supplementing or even replacing the homologous promoter to provide for increased protein expression. The homologous promoter can be supplemented by insertion of one or more heterologous enhancer elements known to confer promoter activation in a particular tissue. 
     The polynucleotides of the present invention also make possible the development, through, e.g., homologous recombination or knock out strategies, of animals that fail to express polypeptides of the invention or that express a variant polypeptide. Such animals are useful as models for studying the in vivo activities of polypeptide as well as for studying modulators of the polypeptides of the invention. 
     In preferred methods to determine biological functions of the polypeptides of the invention in vivo, one or more genes provided by the invention are either over expressed or inactivated in the germ line of animals using homologous recombination [Capecchi, Science 244:1288-1292 (1989)]. Animals in which the gene is over expressed, under the regulatory control of exogenous or endogenous promoter elements, are known as transgenic animals. Animals in which an endogenous gene has been inactivated by homologous recombination are referred to as “knockout” animals. Knockout animals, preferably non-human mammals, can be prepared as described in U.S. Pat. No. 5,557,032, incorporated herein by reference. Transgenic animals are useful to determine the roles polypeptides of the invention play in biological processes, and preferably in disease states. Transgenic animals are useful as model systems to identify compounds that modulate lipid metabolism. Transgenic animals, preferably non-human mammals, are produced using methods as described in U.S. Pat. No. 5,489,743 and PCT Publication No. WO94/28122, incorporated herein by reference. 
     Transgenic animals can be prepared wherein all or part of the polynucleotides of the invention promoter is either activated or inactivated to alter the level of expression of the polypeptides of the invention. Inactivation can be carried out using homologous recombination methods described above. Activation can be achieved by supplementing or even replacing the homologous promoter to provide for increased protein expression. The homologous promoter can be supplemented by insertion of one or more heterologous enhancer elements known to confer promoter activation in a particular tissue. 
     3.10 Uses and Biological Activity 
     The polynucleotides and proteins of the present invention are expected to exhibit one or more of the uses or biological activities (including those associated with assays cited herein) identified herein. Uses or activities described for proteins of the present invention may be provided by administration or use of such proteins or of polynuclcotides encoding such proteins (such as, for example, in gene therapies or vectors suitable for introduction of DNA). The mechanism underlying the particular condition or pathology will dictate whether the polypeptides of the invention, the polynucleotides of the invention or modulators (activators or inhibitors) thereof would be beneficial to the subject in need of treatment. Thus, “therapeutic compositions of the invention” include compositions comprising isolated polynucleotides (including recombinant DNA molecules, cloned genes and degenerate variants thereof) or polypeptides of the invention (including full length protein, mature protein and truncations or domains thereof), or compounds and other substances that modulate the overall activity of the target gene products, either at the level of target gene/protein expression or target protein activity. Such modulators include polypeptides, analogs, (variants), including fragments and fusion proteins, antibodies and other binding proteins; chemical compounds that directly or indirectly activate or inhibit the polypeptides of the invention (identified, e.g., via drug screening assays as described herein); antisense polynucleotides and polynucleotides suitable for triple helix formation; and in particular antibodies or other binding partners that specifically recogrize one or more epitopes of the polypeptides of the invention. 
     The polypeptides of the present invention may likewise be involved in cellular activation or in one of the other physiological pathways described herein. 
     3.10.1 Research Uses and Utilities 
     The polynucleotides provided by the present invention can be used by the research community for various purposes. The polynucleotides can be used to express recombinant protein for analysis, characterization or therapeutic use; as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in disease states); as molecular weight markers on gels; as chromosome markers or tags (when labeled) to identify chromosomes or to map related gene positions; to compare with endogenous DNA sequences in patients to identify potential genetic disorders; as probes to hybridize and thus discover novel, related DNA sequences; as a source of information to derive PCR primers for genetic fingerprinting; as a probe to “subtract-out” known sequences in the process of discovering other novel polynucleotides; for selecting and making oligomers for attachment to a “gene chip” or other support, including for examination of expression patterns; to raise anti-protein antibodies using DNA immunization techniques; and as an antigen to raise anti-DNA antibodies or elicit another immune response. Where the polynucleotide encodes a protein which binds or potentially binds to another protein (such as, for example, in a receptor-ligand interaction), the polynucleotide can also be used in interaction trap assays (such as, for example, that described in Gyuris et al., Cell 75:791-803 (1993)) to identify polynucleotides encoding the other protein with which binding occurs or to identify inhibitors of the binding interaction. 
     The polypeptides provided by the present invention can similarly be used in assays to determine biological activity, including in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its receptor) in biological fluids; as markers for tissues in which the corresponding polypeptide is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state); and, of course, to isolate correlative receptors or ligands. Proteins involved in these binding interactions can also be used to screen for peptide or small molecule inhibitors or agonists of the binding interaction. 
     Any or all of these research utilities are capable of being developed into reagent grade or kit format for corrjercialization as research products. 
     Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include without limitation “Molecular Cloning: A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory Press, in Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and “Methods in Enzymology: Guide to Molecular Cloning Techniques”, Academic Press, Berger, S. L. and A. R Kimmel eds., 1987. 
     3.10.2 Nutritional Uses 
     Polynucleotides and polypeptides of the present invention can also be used as nutritional sources or supplements. Such uses include without limitation use as a protein or amino acid supplement, use as a carbon source, use as a nitrogen source and use as a source of carbohydrate. In such cases the polypeptidc or polynucleotide of the invention can be added to the feed of a particular organism or can be administered as a separate solid or liquid preparation, such as in the form of powder, pills, solutions, suspensions or capsules. In the case of microorganisms, the polypeptide or polynucleotide of the invention can be added to the medium in or on which the microorganism is cultured. 
     3.10.3 Cytokine and Cell Proliferation/Differentiation Activity 
     A polypeptide of the present invention may exhibit activity relating to cytokine, cell proliferation (either inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may induce production of other cytokines in certain cell populations. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Many protein factors discovered to date, including all known cytokines, have exhibited activity in one or more factor-dependent cell proliferation assays, and hence the assays serve as a convenient confirmation of cytokine activity. The activity of therapeutic compositions of the present invention is evidenced by any one of a number of routine factor dependent cell proliferation assays for cell lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/11, BaF3, MC9/G, M+(preB M+), 2E8, RB5, DA1, 123, T1165, HT2, CTLL2, TF-1, Mo7e, CMK, HUVEC, and Caco. Therapeutic compositions of the invention can be used in the following: 
     Assays for T-cell or thymocyte proliferation include without limitation those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Bertagnolli et al., J. Immunol. 145:1706-1712, 1990; Bertagnolli et al., Cellular Imrnunology 133:327-341, 1991; Bertagnolli, et al., I. Immunol. 149:3778-3783, 1992; Bowman et al., I. Immunol. 152:1756-1761, 1994. 
     Assays for cytokine production and/or proliferation of spleen cells, lymph node cells or thymocytes include, without limitation, those described in: Polyclonal T cell stimulation, Kruisbeek, A. M. and Shevach, E. M. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 3.12.1-3.12.14, John Wiley and Sons, Toronto. 1994; and Measurement of mouse and human interleukin-y, Schreiber, R. D. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.8.1-6.8.8, John Wiley and Sons, Toronto. 1994. 
     Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells include, without limitation, those described in: Measurement of Human and Murine Interleukin 2 and Interleukin 4, Bottomly, K., Davis, L. S. and Lipsky, P. E. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and Sons, Toronto. 1991; devries et al., J. Exp. Med. 173:1205-1211, 1991; Moreau et al., Nature 336:690-692, 1988; Greenberger et al., Proc. Natl. Acad. Sci. U.S.A. 80:2931-2938, 1983; Measurement of mouse and human interleukin 6—Nordan, R. In Current Protocols in Immunology. J. E. Coligan eds. Vol 1 pp. 6.6.1-6.6.5, John Wilcy and Sons, Toronto. 1991; Smith et al., Proc. Natl. Aced. Sci. U.S.A. 83:1857-1861, 1986; Measurement of human Interleukin 11—Bennett, F., Giannotti, J., Clark, S. C. and Turner, K. J. In Current Protocols in Immunology. J. E. Coligan eds. Vol 1 pp. 6.15.1 John Wiley and Sons, Toronto. 1991; Measurement of mouse and human Interlcukin 9—Ciarletta, A., Giannotti, J., Clark, S. C. and Turner, K. J. In Current Protocols in Imnnunology. J. E. Coligan eds. Vol I pp. 6.13.1, John Wiley and Sons, Toronto. 1991. 
     Assays for T-cell clone responses to antigens (which will identify, among others, proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring proliferation and cytokine production) include, without limitation, those described in: A Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function; Chapter 6, Cytokines and their cellular receptors; Chapter 7, Immunologic studies in Humans); Weinberger et al., Proc. Natl. Acad. Sci. USA 77:6091-6095, 1980; Weinberger et al., Eur. J. Immun. 11:405-411, 1981; Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988. 
     3.10.4 Stem Cell Growth Factor Activity 
     A polypeptide of the present invention may exhibit stem cell growth factor activity and be involved in the proliferation, differentiation and survival of pluripotent and totipotent stem cells including primordial germ cells, embryonic stem cells, hematopoietic stem cells and/or germ line stem cells. Administration of the polypeptide of the invention to stem cells in vivo or ex vivo is expected to maintain and expand cell populations in a totipotential or pluripotential state which would be useful for re-engineering damaged or diseased tissues, transplantation, manufacture of bio-pharmaceuticals and the development of bio-sensors. The ability to produce large quantities of human cells has important working applications for the production of human proteins which currently must be obtained from non-human sources or donors, implantation of cells to treat diseases such as Parkinson&#39;s, Alzheimer&#39;s and other neurodegenerative diseases; tissues for grafting such as bone marrow, skin, cartilage, tendons, bone, muscle (including cardiac muscle), blood vessels, cornea, neural cells, gastrointestinal cells and others; and organs for transplantation such as kidney, liver, pancreas (including islet cells), heart and lung. 
     It is contemplated that multiple different exogenous growth factors and/or cytokines may be administered in combination with the polypeptide of the invention to achieve the desired effect, including any of the growth factors listed herein, other stem cell maintenance factors, and specifically including stem cell factor (SCF), leukemia inhibitory factor (LIF), Flt-3 ligand (Flt-3L), any of the interleukins, recombinant soluble IL-6 receptor fused to IL-6, macrophagc inflammatory protein 1-alpha (MIP-1-alpha), G-CSF, GM-CSF, thrombopoietin (TPO), platelet factor 4 (PF-4), platelet-derived growth factor (PDGF), neural growth factors and basic fibroblast growth factor (bFGF). 
     Since totipotent stem cells can give rise to virtually any mature cell type, expansion of these cells in culture will facilitate the production of large quantities of mature cells. Techniques for culturing stem cells are known in the art and administration of polypeptides of the invention, optionally with other growth factors and/or cytokines, is expected to enhance the survival and proliferation of the stem cell populations. This can be accomplished by direct administration of the polypeptide of the invention to the culture medium. Alternatively, stroma cells transfected with a polynucleotide that encodes for the polypeptide of the invention can be used as a feeder layer for the stem cell populations in culture or in vivo. Stromal support cells for feeder layers may include embryonic bone marrow fibroblasts, bone marrow stromal cells, fetal liver cells, or cultured embryonic fibroblasts (see U.S. Pat. No. 5,690,926). 
     Stem cells themselves can be transfected with a polynucleotide of the invention to induce autocrine expression of the polypeptide of the invention. This will allow for generation of undifferentiated totipotential/pluripotential stem cell lines that are useful as is or that can then be differentiated into the desired mature cell types. These stable cell lines can also serve as a source of undifferentiated totipotential/pluripotential mRNA to create cDNA libraries and templates for polymerase chain reaction experiments. These studies would allow for the isolation and identification of differentially expressed genes in stem cell populations that regulate stem cell proliferation and/or maintenance. 
     Expansion and maintenance of totipotent stem cell populations will be useful in the treatment of many pathological conditions. For example, polypeptides of the present invention may be used to manipulate stem cells in culture to give rise to neuroepithelial cells that can be used to augment or replace cells damaged by illness, autoimmune disease, accidental damage or genetic disorders. The polypeptide of the invention may be useful for inducing the proliferation of neural cells and for the regeneration of nerve and brain tissue, i.e. for the treatment of central and peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic disorders which involve degeneration, death or trauma to neural cells or nerve tissue. In addition, the expanded stem cell populations can also be genetically altered for gene therapy purposes and to decrease host rejection of replacement tissues after grafting or implantation. 
     Expression of the polypeptide of the invention and its effect on stem cells can also be manipulated to achieve controlled differentiation of the stem cells into more differentiated cell types. A broadly applicable method of obtaining pure populations of a specific differentiated cell type from undifferentiated stem cell populations involves the use of a cell-type specific promoter driving a selectable marker. The selectable marker allows only cells of the desired type to survive. For example, stem cells can be induced to differentiate into cardiomyocytes (Wobus et al., Differentiation, 48: 173-182, (1991); Klug et al., J. Clin. Invest., 98(1): 216-224, (1998)) or skeletal muscle cells (Browder, L. W. In:  Principles of Tissue Engineering eds . Lanza et al., Acadernic Press (1997)). Alternatively, directed differentiation of stem cells can be accomplished by culturing the stem cells in the presence of a differentiation factor such as retinoic acid and an antagonist of the polypeptide of the invention which would inhibit the effects of endogenous stem cell factor activity and allow differentiation to proceed. 
     In vitro cultures of stem cells can be used to determine if the polypeptide of the invention exhibits stem cell growth factor activity. Stem cells are isolated from any one of various cell sources (including hematopoietic stem cells and embryonic stem cells) and cultured on a feeder layer, as described by Thompson et al. Proc. Natl. Acad. Sci, U.S.A., 92: 7844-7848 (1995), in the presence of the polypeptide of the invention alone or in combination with other growth factors or cytokines. The ability of the polypeptide of the invention to induce stem cells proliferation is determined by colony formation on semi-solid support e.g. as described by Bernstein et al., Blood, 77: 2316-2321 (1991). 
     3.10.5 Hematopoiesis Regulating Activity 
     A polypeptide of the present invention may be involved in regulation of hematopoiesis and, consequently, in the treatment of myeloid or lymphoid cell disorders. Even marginal biological activity in support of colony forming cells or of factor-dependent cell lines indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and proliferation of erythwid progenitor cells alone or in combination with other cytokines, thereby indicating utility, for example, in treating various anemias or for use in conjunction with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or erythroid cells; in supporting the growth and proliferation of myeloid cells such as granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for example, in conjunction with chemotherapy to prevent or treat consequent myelo-suppression; in supporting the growth and proliferation of megakaryocytes and consequently of platelets thereby allowing prevention or treatment of various platelet disorders such as thrombocytopenia, and generally for use in place of or complimentary to platelet transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells which are capable of maturing to any and all of the above-mentioned hematopoietic cells and therefore find therapeutic utility in various stem cell disorders (such as those usually treated with transplantation, including, without limitation, aplastic anemia and paroxysmal nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow transplantation or with peripheral progenitor cell transplantation (homologous or heterologous)) as normal cells or genetically manipulated for gene therapy. 
     Therapeutic compositions of the invention can be used in the following: 
     Suitable assays for proliferation and differentiation of various hematopoietic lines are cited above. 
     Assays for embryonic stem cell differentiation (which will identify, among others, proteins that influence embryonic differentiation hematopoiesis) include, without limitation, those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al., Molecular and Cellular Biology 13:473-486, 1993; McClanahan et al., Blood 81:2903-2915, 1993. 
     Assays for stem cell survival and differentiation (which will identify, among others, proteins that regulate lympho-hematopoiesis) include, without limitation, those described in: Methylcellulose colony formring assays, Freshney, M. G. In Culture of Hematopoietic Cells. R. L. Freshney, et al. eds. Vol pp. 265-268, Wiley-Liss, Inc., New York, N.Y. 1994; Hirayama et al., Proc. Natl. Acad. Sci. USA 89:5907-5911, 1992; Primitive hematopoietic colony forming cells with high proliferative potential, McNiece, I. K. and Briddell, R. A. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 23-39, Wiley-Liss, Inc., New York, N.Y. 1994; Neben et al., Experimental Hematology 22:353-359, 1994; Cobblestone area forming cell assay, Ploemacher, R. E. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, N.Y. 1994; Long term bone marrow cultures in the presence of stromal cells, Spooncer, E., Dexter, M. and Allen, T. In Culture of Hematopoietic Cells. R. I. Freshney, et al. eds. Vol pp. 163-179, Wiley-Liss, Inc., New York, N.Y. 1994; Long term culture initiating cell assay, Sutherland, H. J. In Culture of Hematopoietic Cells. R I. Freshney, et al. eds. Vol pp. 139-162, Wiley-Liss, Inc., New York, N.Y. 1994. 
     3.10.6 Tissue Growth Activity 
     A polypeptide of the present invention also may be involved in bone, cartilage, tendon, ligament and/or nerve tissue growth or regeneration, as well as in wound healing and tissue repair and replacement, and in healing of bums, incisions and ulcers. 
     A polypeptide of the present invention which induces cartilage and/or bone growth in circumstances where bone is not normally formed, has application in the healing of bone fractures and cartilage damage or defects in humans and other animals. Compositions of a polypeptide, antibody, binding partner, or other modulator of the invention may have prophylactic use in closed as well as open fracture reduction and also in the improved fixation of artificial joints. De novo bone formation induced by an osteogenic agent contributes to the repair of congenital, trauma induced, or oncologic resection induced craniofacial defects, and also is useful in cosmetic plastic surgery. 
     A polypeptide of this invention may also be involved in attracting bone-forming cells, stimulating growth of bone-formning cells, or inducing differentiation of progenitors of bone-forming cells. Treatment of osteoporosis, osteoarthritis, bone degenerative disorders, or periodontal disease, such as through stimulation of bone and/or cartilage repair or by blocking inflammation or processes of tissue destruction (collagenase activity, osteoclast activity, etc.) mediated by inflammatory processes may also be possible using the composition of the invention. 
     Another category of tissue regeneration activity that may involve the polypeptide of the present invention is tendon/ligament formation. Induction of tendon/ligament-like tissue or other tissue formation in circumstances where such tissue is not normally formed, has application in the healing of tendon or ligament tears, deformities and other tendon or ligament defects in humans and other animals. Such a preparation employing a tendon/ligament-like tissue inducing protein may have prophylactic use in preventing damage to tendon or ligament tissue, as well as use in the improved fixation of tendon or ligament to bone or other tissues, and in repairing defects to tendon or ligament tissue. De novo tendon/ligament-like tissue formation induced by a composition of the present invention contributes to the repair of congenital, trauma induced, or other tendon or ligament defects of other origin, and is also useful in cosmetic plastic surgery for attachment or repair of tendons or ligaments. The compositions of the present invention may provide environment to attract tendon- or ligament-forrning cells, stimulate growth of tendon- or ligament-forming cells, induce differentiation of progenitors of tendon- or ligament-forming cells, or induce growth of tendon/liganent cells or progenitors ex vivo for return in vivo to effect tissue repair. The compositions of the invention may also be useful in the treatment of tendinitis, carpal tunnel syndrome and other tendon or ligament defects. The compositions may also include an appropriate matrix and/or sequestering agent as a carrier as is well known in the art. 
     The compositions of the present invention may also be useful for proliferation of neural cells and for regeneration of nerve and brain tissue, i.e. for the treatment of central and peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic disorders, which involve degeneration, death or trauma to neural cells or nerve tissue. More specifically, a composition may be used in the treatment of diseases of the peripheral nervous system, such as peripheral nerve injuries, peripheral neuropathy and localized neuropathies, and central nervous system diseases, such as Alzheimer&#39;s, Parkinson&#39;s disease, Huntington&#39;s disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome. Further conditions which may be treated in accordance with the present invention include mechanical and traumatic disorders, such as spinal cord disorders, head trauma and cerebrovascular diseases such as stroke. Peripheral neuropathies resulting from chemotherapy or other medical therapies may also be treatable using a composition of the invention. 
     Compositions of the invention may also be useful to promote better or faster closure of non-healing wounds, including without limitation pressure ulcers, ulcers associated with vascular insufficiency, surgical and traumatic wounds, and the like. 
     Compositions of the present invention may also be involved in the generation or regeneration of other tissues, such as organs (including, for example, pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac) and vascular (including vascular endothelium) tissue, or for promoting the growth of cells comprising such tissues. Part of the desired effects may be by inhibition or modulation of fibrotic scarring may allow normal tissue to regenerate. A polypeptide of the present invention may also exhibit angiogenic activity. 
     A composition of the present invention may also be useful for gut protection or regeneration and treatment of lung or liver fibrosis, reperfusion injury in various tissues, and conditions resulting from systemic cytokine damage. 
     A composition of the present invention may also be useful for promoting or inhibiting differentiation of tissues described above from precursor tissues or cells; or for inhibiting the growth of tissues described above. 
     Therapeutic compositions of the invention can be used in the following: 
     Assays for tissue generation activity include, without limitation, those described in: International Patent Publication No. WO95/16035 (bone, cartilage, tendon); International Patent Publication No. WO95/05846 (nerve, neuronal); International Patent Publication No. WO91/07491 (skin, endothelium). 
     Assays for wound healing activity include, without limitation, those described in: Winter, Epidermal Wound Healing, pps. 71-112 (Maibach, H. L. and Rovee, D. T., eds.), Year Book Medical Publishers, Inc., Chicago, as modified by Eaglstein and Mertz, J. Invest. Dermatol 71:382-84 (1978). 
     3.10.7 Immune Stimulating or Suppressing Activity 
     A polypeptide of the present invention may also exhibit immune stimulating or immune suppressing activity, including without limitation the activities for which assays are described herein. A polynucleotide of the invention can encode a polypeptide exhibiting such activities. A protein may be useful in the treatment of various immune deficiencies and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating (up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the cytolytic activity of NK cells and other cell populations. These immune deficiencies may be genetic or be caused by viral (e.g., HI) as well as bacterial or fungal infections, or may result from autoimmune disorders. Morc specifically, infectious diseases causes by viral, bacterial, ftngal or other infection may be treatable using a protein of the present invention, including infections by HIV, hepatitis viruses, herpes viruses, mycobacteria, Leishmania spp., malaria spp. and various fungal infections such as candidiasis. Of course, in this regard, proteins of the present invention may also be useful where a boost to the immune system generally may be desirable, i.e., in the treatment of cancer. 
     Autoimmune disorders which may be treated using a protein of the present invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitis, myasthenia gravis, graft-versus-host disease and autoimmune inflammatory eye disease. Such a protein (or antagonists thereof, including antibodies) of the present invention may also to be useful in the treatment of allergic reactions and conditions (e.g., anaphylaxis, serum sickness, drug reactions, food allergies, insect venom allergies, mastocytosis, allergic rhinitis, hypersensitivity pneumonitis, urticaria, angioedema, eczema, atopic dermatitis, allergic contact dermatitis, erythema multiforme, Stevens-Johnson syndrome, allergic conjunctivitis, atopic keratoconjunctivitis, venereal keratoconjunctivitis, giant papillary conjunctivitis and contact allergies), such as asthma (particularly allergic asthma) or other respiratory problems. Other conditions, in which inrnune suppression is desired (including, for example, organ transplantation), may also be treatable using a protein (or antagonists thereof) of the present invention. The therapeutic effects of the polypeptides or antagonists thereof on allergic reactions can be evaluated by in vivo animals models such as the cumulative contact enhancement test (Lastbom et al., Toxicology 125: 59-66, 1998), skin prick test (Hoffmann et al., Allergy 54: 446-54, 1999), guinea pig skin sensitization test (Vohr et al., Arch. Toxocol. 73: 501-9), and murine local lymph node assay (Kimber et al., J. Toxicol. Environ. Health 53: 563-79). 
     Using the proteins of the invention it may also be possible to modulate immune responses, in a number of ways. Down regulation may be in the form of inhibiting or blocking an immune response already in progress or may involve preventing the induction of an immune response. The functions of activated T cells may be inhibited by suppressing T cell responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T cell responses is generally an active, non-antigen-specific, process which requires continuous exposure of the T cells to the suppressive agent. Tolerance, which involves inducing non-responsiveness or anergy in T cells, is distinguishable from immunosuppression in that it is generally antigen-specific and persists after exposure to the tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of a T cell response upon reexposure to specific antigen in the absence of the tolerizing agent. 
     Down regulating or preventing one or more antigen functions (including without limitation B lymphocyte antigen functions (such as, for example, B7)), e.g., preventing high level lymphokine synthesis by activated T cells, will be useful in situations of tissue, skin and organ transplantation and in graft-versus-host disease (GVHD). For example, blockage of T cell function should result in reduced tissue destruction in tissue transplantation. Typically, in tissue transplants, rejection of the transplant is initiated through its recognition as foreign by T cells, followed by an immune reaction that destroys the transplant. The administration of a therapeutic composition of the invention may prevent cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant. Moreover, a lack of costimulation may also be sufficient to energize the T cells, thereby inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-blocking reagents may avoid the necessity of repeated administration of these blocking reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also be necessary to block the function of a combination of B lymphocyte antigens. 
     The efficacy of particular therapeutic compositions in preventing organ transplant rejection or GVHD can be assessed using animal models that are predictive of efficacy in humans. Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to examine the immunosuppressive effects of CTLA4Ig fusion proteins in vivo as described in Lenschow et al., Science 257:789-792 (1992) and Turka et al., Proc. Natl. Acad. Sci USA, 89:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 846-847) can be used to determine the effect of therapeutic compositions of the invention on the development of that disease. 
     Blocking antigen function may also be therapeutically useful for treating autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation of T cells that are reactive against self tissue and which promote the production of cytokines and autoantibodies involved in the pathology of the diseases. Preventing the activation of autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents which block stimulation of T cells can be used to inhibit T cell activation and prevent production of autoantibodies or T cell-derived cytokines which may be involved in the disease process. Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells which could lead to long-term relief from the disease. The efficacy of blocking reagents in preventing or alleviating autoimmune disorders can be determined using a number of well-characterized animal models of human autoimmune diseases. Examples include murine experimental autoimmune encephalitis, systemic lupus erythmatosis in MRL/lpr/lpr mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD mice and BB rats, and murine experimental myasthenia gravis (see Paul ed., Fundamental Immunology, Raven Press, New York, 1989, pp. 840-856). 
     Upregulation of an antigen function (e.g., a B lymphocyte antigen function), as a means of up regulating immune responses, may also be useful in therapy. Upregulation of immune responses may be in the form of enhancing an existing immune response or eliciting an initial immune response. For example, enhancing an immune response may be useful in cases of viral infection, including systemic viral diseases such as influenza, the common cold, and encephalitis. 
     Alternatively, anti-viral immune responses may be enhanced in an infected patient by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-pulsed APCs either expressing a peptide of the present invention or together with a stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro activated T cells into the patient. Another method of enhancing anti-viral immune responses would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding a protein of the present invention as described herein such that the cells express all or a portion of the protein on their surface, and reintroduce the transfected cells into the patient. The infected cells would now be capable of delivering a costimulatory signal to, and thereby activate, T cells in vivo. 
     A polypeptide of the present invention may provide the necessary stimulation signal to T cells to induce a T cell mediated immune response against the transfected tumor cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or which fail to reexpress sufficient mounts of MHC class I or MHC class II molecules, can be transfected with nucleic acid encoding all or a portion of (e.g., a cytoplasmic-domain truncated portion) of an MHC class I alpha chain protein and β 2  microglobulin protein or an MHC class II alpha chain protein and an MHC class II beta chain protein to thereby express MHC class I or MHC class II proteins on the cell surface. Expression of the appropriate class I or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen (e.g., B7-1, B7-2, B7-3) induces a T cell mediated immune response against the transfected tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of an MHC class II associated protein, such as the invariant chain, can also be cotransfected with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote presentation of tumor associated antigens and induce tumor specific immunity. Thus, the induction of a T cell mediated immune response in a human subject may be sufficient to overcome tumor-specific tolerance in the subject. 
     The activity of a protein of the invention may, among other means, be measured by the following methods: 
     Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Herrmann et al., Proc. Natl. Acad. Sci. USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa et al., J. Immunol. 135:1564-1572, 1985; Takai et al., I. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Bowman et al., J. Virology 61:1992-1998; Bertagnolli et al., Cellular Immunology 133:327-341, 1991; Brown et al., J. Immunol. 153:3079-3092, 1994. 
     Assays for T-cell-dependent immunoglobulin responses and isotype switching (which will identify, among others, proteins that modulate T-cell dependent antibody responses and that affect Th1/Th2 profiles) include, without limitation, those described in: Maliszewski, J. Immunol. 144:3028-3033, 1990; and Assays for B cell function: In vitro antibody production, Mond, J. J. and Brunswick, M. In Current Protocols in Immunology. J. E. e.a. Coligan eds. Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto. 1994. 
     Mixed lymphocyte reaction (MLR) assays (which will identify, among others, proteins that generate predominantly Th1 and CTL responses) include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J. Immunol. 140:508-512, 1988; Bertagnolli et al., J. Immunol. 149:3778-3783, 1992. 
     Dendritic cell-dependent assays (which will identify, among others, proteins expressed by dendritic cells that activate naive T-cells) include, without limitation, those described in: Guery et al., J. Immunol. 134:536-544, 1995; Inaba et al., Journal of Experimental Medicine 173:549-559, 1991; Macatonia et al., Journal of Immunology 154:5071-5079, 1995; Porgador et al., Journal of Experimental Medicine 182:255-260, 1995; Nair et al., Journal of Virology 67:4062-4069, 1993; Huang et al., Science 264:961-965, 1994; Macatonia et al., Journal of Experimental Medicine 169:1255-1264, 1989; Bhardwaj et al., Journal of Clinical Investigation 94:797-807, 1994; and Inaba et al., Journal of Experimental Medicine 172:631-640, 1990. 
     Assays for lymphocyte survival/apoptosis (which will identify, among others, proteins that prevent apoptosis after superantigen induction and proteins that regulate lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et al., Cytometry 13:795-808, 1992; Gorczyca et al., Leukemia 7:659-670, 1993; Gorczyca et al., Cancer Research 53:1945-1951, 1993; Itoh et al., Cell 66:233-243, 1991; Zacharchuk, Journal of Immunology 145:4037-4045, 1990; Zamai et al., Cytometry 14:891-897, 1993; Gorczyca et al., International Journal of Oncology 1:639-648, 1992. 
     Assays for proteins that influence early steps of T-cell commitment and development include, without limitation, those described in: Antica et al., Blood 84:111-117, 1994; Fine et al., Cellular Immunology 155:111-122, 1994; Galy et al., Blood 85:2770-2778, 1995; Toki et al., Proc. Nat. Acad Sci. USA 88:7548-7551, 1991. 
     3.10.8 Activin/Inhibin Activity 
     A polypeptide of the present invention may also exhibit activin- or inhibin-related activities. A polynucleotide of the invention may encode a polypeptide exhibiting such characteristics. Inhibins are characterized by their ability to inhibit the release of follicle stimulating hormone (FSH), while activins and are characterized by their ability to stimulate the release of follicle stimulating hormone (FSH). Thus, a polypeptide of the present invention, alone or in heterodimers with a member of the inhibin family, may be useful as a contraceptive based on the ability of inhibins to decrease fertility in female mammals and decrease spermatogenesis in male mammals. Administration of sufficient amounts of other inhibins can induce infertility in these mammals. Alternatively, the polypeptide of the invention, as a homodimer or as a heterodimer with other protein subunits of the inhibin group, may be useful as a fertility inducing therapeutic, based upon the ability of activin molecules in stimulating FSH release from cells of the anterior pituitary. See, for example, U.S. Pat. No. 4,798,885. A polypeptide of the invention may also be useful for advancement of the onset of fertility in sexually immature mammals, so as to increase the lifetime reproductive performance of domestic animals such as, but not limited to, cows, sheep and pigs. 
     The activity of a polypeptide of the invention may, among other means, be measured by the following methods. 
     Assays for activin/inhibin activity include, without limitation, those described in: Vale et al., Endocrinology 91:562-572, 1972; Ling et al., Nature 321:779-782, 1986; Vale et al., Nature 321:776-779, 1986; Mason et al., Nature 318:659-663, 1985; Forage et al., Proc. Natl. Acad. Sci. USA 83:3091-3095, 1986. 
     3.10.9 Cremotactic/Chemokinetic Activity 
     A polypeptide of the present invention may be involved in chemotactic or chemokinetic activity for mammalian cells, including, for example, monocytes, fibroblasts, neutrophils, T-cells, mast cells, eosinophils, epithelial and/or endothelial cells. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Chemotactic and chemokinetic receptor activation can be used to mobilize or attract a desired cell population to a desired site of action. Chemotactic or chemokinetic compositions (e.g. proteins, antibodies, binding partners, or modulators of the invention) provide particular advantages in treatment of wounds and other trauma to tissues, as well as in treatment of localized infections. For example, attraction of lymphocytes, monocytes or neutrophils to tumors or sites of infection may result in improved immune responses against the tumor or infecting agent. 
     A protein or peptide has chemotactic activity for a particular cell population if it can stimulate, directly or indirectly, the directed orientation or movement of such cell population. Preferably, the protein or peptide has the ability to directly stimulate directed movement of cells. Whether a particular protein has chemotactic activity for a population of cells can be readily determined by employing such protein or peptide in any known assay for cell chemotaxis. 
     Therapeutic compositions of the invention can be used in the following: 
     Assays for chemotactic activity (which will identify proteins that induce or prevent chemotaxis) consist of assays that measure the ability of a protein to induce the migration of cells across a membrane as well as the ability of a protein to induce the adhesion of one cell population to another cell population. Suitable assays for movement and adhesion include, without limitation, those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Marguiles, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 6.12, Measurernent of alpha and beta Chemokines 6.12.1-6.12.28; Taub et al. J. Clin. Invest. 95:1370-1376, 1995; Lind et al. APMIS 103:140-146, 1995; Muller et al Eur. J. Immunol. 25:1744-1748; Gruber et al. J. of Immunol. 152:5860-5867, 1994; Johnston et al. J. of Immunol. 153:1762-1768, 1994. 
     3.10.10 Hemostatic and Thrombolytic Activity 
     A polypeptide of the invention may also be involved in hemostatis or thrombolysis or thrombosis. A polynucleotide of the invention can encode a polypeptide exhibiting such attributes. Compositions may be useful in treatment of various coagulation disorders (including hereditary disorders, such as hemophilias) or to enhance coagulation and other hemostatic events in treating wounds resulting from trauma, surgery or other causes. A composition of the invention may also be useful for dissolving or inhibiting formation of thromboses and for treatment and prevention of conditions resulting therefrom (such as, for example, infarction of cardiac and central nervous system vessels (e.g., stroke). 
     Therapeutic compositions of the invention can be used in the following: 
     Assay for hemostatic and thrombolytic activity include, without limitation, those described in: Linet et al., J. Clin. Pharmacol. 26:131-140, 1986; Burdick et al., Thrombosis Res. 45:413-419, 1987; Humphrey et al., Fibrinolysis 5:71-79 (1991); Schaub, Prostaglandins 35:467-474, 1988. 
     3.10.11 Cancer Diagnosis and Therapy 
     Polypeptides of the invention may be involved in cancer cell generation, proliferation or metastasis. Detection of the presence or amount of polynucleotides or polypeptides of the invention may be useful for the diagnosis and/or prognosis of one or more types of cancer. For example, the presence or increased expression of a polynucleotide/polypeptide of the invention may indicate a hereditary risk of cancer, a precancerous condition, or an ongoing malignancy. Conversely, a defect in the gene or absence of the polypeptide may be associated with a cancer condition. Identification of single nucleotide polymorphisms associated with cancer or a predisposition to cancer may also be useful for diagnosis or prognosis. 
     Cancer treatments promote tumor regression by inhibiting tumor cell proliferation, inhibiting angiogenesis (growth of new blood vessels that is necessary to support tumor growth) and/or prohibiting metastasis by reducing tumor cell motility or invasiveness. Therapeutic compositions of the invention may be effective in adult and pediatric oncology including in solid phase tumors/malignancies, locally advanced tumors, human soft tissue sarcomas, metastatic cancer, including lymphatic metastases, blood cell malignancies including multiple myeloma, acute and chronic leukemnias, and lymphomas, head and neck cancers including mouth cancer, larynx cancer and thyroid cancer, lung cancers including small cell carcinoma and non-small cell cancers, breast cancers including small cell carcinoma and ductal carcinoma, gastrointestinal cancers including esophageal cancer, stomach cancer, colon cancer, colorectal cancer and polyps associated with colorectal neoplasia, pancreatic cancers, liver cancer, urologic cancers including bladder cancer and prostate cancer, malignancies of the female genital tract including ovarian carcinoma, uterine (including endometrial) cancers, and solid tumor in the ovarian follicle, kidney cancers including renal cell carcinoma, brain cancers including intrinsic brain tumors, neuroblastoma, astrocytic brain tumors, gliomas, metastatic tumor cell invasion in the central nervous system, bone cancers including osteomas, skin cancers including malignant melanoma, tumor progression of human skin keratinocytes, squamous cell carcinoma, basal cell carcinoma, hemangiopericytoma and Karposi&#39;s sarcoma. 
     Polypeptides, polynucleotides, or modulators of polypeptides of the invention (including inhibitors and stimulators of the biological activity of the polypeptide of the invention) may be administered to treat cancer. Therapeutic compositions can be administered in therapeutically effective dosages alone or in combination with adjuvant cancer therapy such as surgery, chemotherapy, radiotherapy, thermotherapy, and laser therapy, and may provide a beneficial effect, e.g. reducing tumor size, slowing rate of tumor growth, inhibiting metastasis, or otherwise improving overall clinical condition, without necessarily eradicating the cancer. 
     The composition can also be administered in therapeutically effective amounts as a portion of an anti-cancer cocktail. An anti-cancer cocktail is a mixture of the polypeptide or modulator of the invention with one or more anti-cancer drugs in addition to a pharmaceutically acceptable carrier for delivery. The use of anti-cancer cocktails as a cancer treatment is routine. Anti-cancer drugs that are well known in the art and can be used as a treatment in combination with the polypeptide or modulator of the invention include: Actinomycin D, Aminoglutethimide, Asparaginase, Bleomycin, Busulfan, Carboplatin, Carmustine, Chlorambucil, Cisplatin (cis-DDP), Cyclophosphamide, Cytarabine HCl (Cytosine arabinoside), Dacarbazine, Dactinomycin, Daunorubicin HCl, Doxorubicin HCl, Estramustine phosphate sodium, Etoposide (V16-213), Floxuridine, 5-Fluorouracil (5-Fu), Flutamide, Hydroxyurea (hydroxycarbamide), Ifosfamide, Interferon Alpha-2a, Interferon Alpha-2b, Leuprolide acetate (LHRH-releasing factor analog), Lomustine, Mechiorethamnine HCl (nitrogen mustard), Melphalan, Mercaptopurine, Mesna, Methotrexate (MTX), Mitomycin, Mitoxantrone HCl, Octreotide, Plicamycin, Procarbazine HCl, Streptozocin, Tamoxifen citrate, Thioguanine, Thiotepa, Vinblastine sulfate, Vincristine sulfate, Ainsacrinc, Azacitidine, Hexamethylnelamine, Interleukin-2, Mitoguazone, Pentostatin, Semustine, Teniposide, and Vindesine sulfate. 
     In addition, therapeutic compositions of the invention may be used for prophylactic treatment of cancer. There are hereditary conditions and/or environmental situations (e.g. exposure to carcinogens) known in the art that predispose an individual to developing cancers. Under these circumstances, it may be beneficial to treat these individuals with therapeutically effective doses of the polypeptide of the invention to reduce the risk of developing cancers. 
     In vitro models can be used to determine the effective doses of the polypeptide of the invention as a potential cancer treatment. These in vitro models include proliferation assays of cultured tumor cells, growth of cultured tumor cells in soft agar (see Freshney, (1987) Culture of Animal Cells: A Manual of Basic Technique, Wily-Liss, New York, N.Y. Ch 18 and Ch 21), tumor systems in nude mice as described in Giovanella et al., J. Natl. Can. Inst., 52: 921-30 (1974), mobility and invasive potential of tumor cells in Boyden Chamber assays as described in Pilkington et al., Anticancer Res., 17: 4107-9 (1997), and angiogenesis assays such as induction of vascularization of the chick chorioallantoic membrane or induction of vascular endothelial cell migration as described in Ribatta et al., Intl. J. Dev. Biol., 40: 1189-97 (1999) and Li et al., Clin. Exp. Metastasis, 17:423-9 (1999), respectively. Suitable tumor cells lines are available, e.g. from American Type Tissue Culture Collection catalogs. 
     3.10.12 Receptor/Ligand Activity 
     A polypeptide of the present invention may also demonstrate activity as receptor, receptor ligand or inhibitor or agonist of receptor/ligand interactions. A polynucleotide of the invention can encode a polypeptide exhibiting such characteristics. Examples of such receptors and ligands include, without limitation, cytokine receptors and their ligands, receptor kinases and their ligands, receptor phosphatases and their ligands, receptors involved in cell-cell interactions and their ligands (including without limitation, cellular adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs involved in antigen presentation, antigen recognition and development of cellular and humoral immune responses. Receptors and ligands are also useful for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. A protein of the present invention (including, without limitation, fragments of receptors and ligands) may themselves be useful as inhibitors of receptor/ligand interactions. 
     The activity of a polypeptide of the invention may, among other means, be measured by the following methods: 
     Suitable assays for receptor-ligand activity include without limitation those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, W. Strober, Pub. Greene Publishing Associates and Wiley-Interscience (Chapter 7.28, Measurement of Cellular Adhesion under static conditions 7.28.1-7.28.22), Takai et al., Proc. Natl. Acad. Sci. USA 84:6864-6868, 1987; Bierer et al., J. Exp. Med. 168:1145-1156, 1988; Rosenstein et al., J. Exp. Med. 169:149-160 1989; Stoltenborg et al., J. Immunol. Methods 175:59-68, 1994; Stitt et al., Cell 80:661-670, 1995. 
     By way of example, the polypeptides of the invention may be used as a receptor for a ligand(s) thereby transmitting the biological activity of that ligand(s). Ligands may be identified through binding assays, affinity chromatography, dihybrid screening assays, BIAcore assays, gel overlay assays, or other methods known in the art. 
     Studies characterizing drugs or proteins as agonist or antagonist or partial agonists or a partial antagonist require the use of other proteins as competing ligands. The polypeptides of the present invention or ligand(s) thereof may be labeled by being coupled to radioisotopes, colorimetric molecules or a toxin molecules by conventional methods. (“Guide to Protein Purification” Murray P. Deutscher (ed) Methods in Enzymology Vol. 182 (1990) Academic Press, Inc. San Diego). Examples of radioisotopes include, but are not limited to, tritium and carbon-14. Examples of calorimetric molecules include, but are not limited to, fluorescent molecules such as fluorescamine, or rhodamine or other colorimetric molecules. Examples of toxins include, but are not limited, to ricin. 
     3.10.13 Drug Screening 
     This invention is particularly useful for screening chemical compounds by using the novel polypeptides or binding fragments thereof in any of a variety of drug screening techniques. The polypeptides or fragments employed in such a test may either be free in solution, affixed to a solid support, borne on a cell surface or located intracellularly. One method of drug screening utilizes eukaryotic or prokaryotic host cells which are stably transformed with recombinant nucleic acids expressing the polypeptide or a fragment thereof. Drugs are screened against such transformed cells in competitive binding assays. Such cells, either in viable or fixed form, can be used for standard binding assays. One may measure, for example, the formation of complexes between polypeptides of the invention or fragments and the agent being tested or examine the diminution in complex formation between the novel polypeptides and an appropriate cell line, which are well known in the art. 
     Sources for test compounds that may be screened for ability to bind to or modulate (i.e., increase or decrease) the activity of polypeptides of the invention include (1) inorganic and organic chemical libraries, (2) natural product libraries, and (3) combinatorial libraries comprised of either random or mimetic peptides, oligonucleotides or organic molecules. 
     Chemical libraries may be readily synthesized or purchased from a number of commercial sources, and may include structural analogs of known compounds or compounds that are identified as “hits” or “leads” via natural product screening. 
     The sources of natural product libraries are microorganisms (including bacteria and fungi), animals, plants or other vegetation, or marine organisms, and libraries of mixtures for screening may be created by: (1) fermentation and extraction of broths from soil, plant or marine microorganisms or (2) extraction of the organisms themselves. Natural product libraries include polyketides, non-ribosomal peptides, and (non-naturally occurring) variants thereof. For a review, see  Science  282:63-68 (1998). 
     Combinatorial libraries are composed of large numbers of peptides, oligonucleotides or organic compounds and can be readily prepared by traditional automated synthesis methods, PCR, cloning or proprietary synthetic methods. Of particular interest are peptide and oligonucleotide combinatorial libraries. Still other libraries of interest include peptide, protein, peptidomimetic, multiparallel synthetic collection, recombinatorial, and polypeptide libraries. For a review of combinatorial chemistry and libraries created therefrom, see Myers,  Curr. Opin. Biotechnol . 8:701-707 (1997). For reviews and examples of peptidomimetic libraries, see Al-Obeidi et al.,  Mol. Biotechnol , 9(3):205-23 (1998); Hrubyet al.,  Curr Opin Chem Biol,  1(1):114-19(1997); Domer et al.,  Bioorg Med Chem , 4(5):709-15 (1996) (alkylated dipeptides). 
     Identification of modulators through use of the various libraries described herein permits modification of the candidate “hit” (or “lead”) to optimize the capacity of the “hit” to bind a polypeptide of the invention. The molecules identified in the binding assay are then tested for antagonist or agonist activity in in vivo tissue culture or animal models that are well known in the art. In brief, the molecules are titrated into a plurality of cell cultures or animals and then tested for either cell/animal death or prolonged survival of the animal/cells. 
     The binding molecules thus identified may be complexed with toxins, e.g., ricin or cholera, or with other compounds that are toxic to cells such as radioisotopes. The toxin-binding molecule complex is then targeted to a tumor or other cell by the specificity of the binding molecule for a polypeptide of the invention. Alternatively, the binding molecules may be complexed with imaging agents for targeting and imaging purposes. 
     3.10.14 Assay for Receptor Activity 
     The invention also provides methods to detect specific binding of a polypeptide e.g. a ligand or a receptor. The art provides numerous assays particularly useful for identifying previously unknown binding partners for receptor polypeptides of the invention. For example, expression cloning using mammalian or bacterial cells, or dihybrid screening assays can be used to identify polynucleotides encoding binding partners. As another example, affinity chromatography with the appropriate immobilized polypeptide of the invention can be used to isolate polypeptides that recognize and bind polypeptides of the invention. There are a number of different libraries used for the identification of compounds, and in particular small molecules, that modulate (i.e., increase or decrease) biological activity of a polypeptide of the invention. Ligands for receptor polypeptides of the invention can also be identified by adding exogenous ligands, or cocktails of ligands to two cells populations that are genetically identical except for the expression of the receptor of the invention: one cell population expresses the receptor of the invention whereas the other does not. The response of the two cell populations to the addition of ligands(s) are then compared. Alternatively, an expression library can be co-expressed with the polypeptide of the invention in cells and assayed for an autocrine response to identify potential ligand(s). As still another example, BIAcore assays, gel overlay assays, or other methods known in the art can be used to identify binding partner polypeptides, including, (1) organic and inorganic chemical libraries, (2) natural product libraries, and (3) combinatorial libraries comprised of random peptides, oligonuclcotides or organic molecules. 
     The role of downstream intracellular signaling molecules in the signaling cascade of the polypeptide of the invention can be determined. For example, a chimeric protein in which the cytoplasmic domain of the polypeptide of the invention is fused to the extracellular portion of a protein, whose ligand has been identified, is produced in a host cell. The cell is then incubated with the ligand specific for the extracellular portion of the chimeric protein, thereby activating the chimeric receptor. Known downstream proteins involved in intracellular signaling can then be assayed for expected modifications i.e. phosphorylation. Other methods known to those in the art can also be used to identify signaling molecules involved in receptor activity. 
     3.10.15 Anti-inflammatory Activity 
     Compositions of the present invention may also exhibit anti-inflammatory activity. The anti-inflammatory activity may be achieved by providing a stimulus to cells involved in the inflammatory response, by inhibiting or promoting cell-cell interactions (such as, for example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or suppressing production of other factors which more directly inhibit or promote an inflammatory response. Compositions with such activities can be used to treat inflammatory conditions including chronic or acute conditions), including without limitation intimation associated with infection (such as septic shock, sepsis or systemic inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality, arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine-induced lung injury, inflammatory bowel disease, Crohn&#39;s disease or resulting from over production of cytokines such as TNF or IL-1. Compositions of the invention may also be useful to treat anaphylaxis and hypersensitivity to an antigenic substance or material. Compositions of this invention may be utilized to prevent or treat conditions such as, but not limited to, sepsis, acute pancreatitis, endotoxin shock, cytokine induced shock, rheumatoid arthritis, chronic inflammatory arthritis, pancreatic cell damage from diabetes mellitus type 1, graft versus host disease, inflammatory bowel disease, inflamation associated with pulmonary disease, other autoimmune disease or inflammatory disease, an antiproliferative agent such as for acute or chronic mylegenous leukemia or in the prevention of premature labor secondary to intrauterine infections. 
     3.10.16 Leukemias 
     Leukemias and related disorders may be treated or prevented by administration of a therapeutic that promotes or inhibits function of the polynucleotides and/or polypeptides of the invention. Such leukemias and related disorders include but are not limited to acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia, myeloblastic, promyclocytic, myelomonocytic, monocytic, erythroleukemia, chronic leukemia, chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia (for a review of such disorders, see Fishman et al., 1985, Medicine, 2d Ed., J. B. Lippincott Co., Philadelphia). 
     3.10.17 Nervous System Disorders 
     Nervous system disorders, involving cell types which can be tested for efficacy of intervention with compounds that modulate the activity of the polynucleotides and/or polypeptides of the invention, and which can be treated upon thus observing an indication of therapeutic utility, include but are not limited to nervous system injuries, and diseases or disorders which result in either a disconnection of axons, a diminution or degeneration of neurons, or demyelination. Nervous system lesions which may be treated in a patient (including human and non-human mammalian patients) according to the invention include but are not limited to the following lesions of either the central (including spinal cord, brain) or peripheral nervous systems: 
     (i) traumatic lesions, including lesions caused by physical injury or associated with surgery, for example, lesions which sever a portion of the nervous system, or compression injuries; 
     (ii) ischemnic lesions, in which a lack of oxygen in a portion of the nervous system results in neuronal injury or death, including cerebral infarction or ischemia, or spinal cord infarction or ischemia; 
     (iii) infectious lesions, in which a portion of the nervous system is destroyed or injured as a result of infection, for example, by an abscess or associated with infection by human immunodeficiency virus, herpes zoster, or herpes simplex virus or with Lymc disease, tuberculosis, syphilis; 
     (iv) degenerative lesions, in which a portion of the nervous system is destroyed or injured as a result of a degenerative process including but not limited to degeneration associated with Parkinson&#39;s disease, Alzheimer&#39;s disease, Huntington&#39;s chorea, or amyotrophic lateral sclerosis; 
     (v) lesions associated with nutritional diseases or disorders, in which a portion of the nervous system is destroyed or injured by a nutritional disorder or disorder of metabolism including but not limited to, vitamin B12 deficiency, folic acid deficiency, Wemicke disease, tobacco-alcohol amblyopia, Marchiafava-Bignami disease (primary degeneration of the corpus callosum), and alcoholic cerebellar degeneration; 
     (vi) neurological lesions associated with systemic diseases including but not limited to diabetes (diabetic neuropathy, Bell&#39;s palsy), systemic lupus erythematosus, carcinoma, or sarcoidosis; 
     (vii) lesions caused by toxic substances including alcohol, lead, or particular neurotoxins; and 
     (viii) demyelinated lesions in which a portion of the nervous system is destroyed or injured by a demyelinating disease including but not limited to multiple sclerosis, human immunodeficiency virus-associated myelopathy, transverse myelopathy or various etiologies, progressive multifocal leukoencephalopathy, and central pontine myelinolysis. 
     Therapeutics which are useful according to the invention for treatment of a nervous system disorder may be selected by testing for biological activity in promoting the survival or differentiation of neurons. For example, and not by way of limitation, therapeutics which elicit any of the following effects may be useful according to the invention: 
     (i) increased survival time of neurons in culture; 
     (ii) increased sprouting of neurons in culture or in vivo; 
     (iii) increased production of a neuron-associated molecule in culture or in vivo, e.g., choline acetyltransferase or acetylcholinesterase with respect to motor neurons; or 
     (iv) decreased symptoms of neuron dysfimction in vivo. 
     Such effects may be measured by any method known in the art. In preferred, non-limiting embodiments, increased survival of neurons may be measured by the method set forth in Arakawa et al. (1990, J. Neurosci. 10:3507-3515); increased sprouting of neurons may be detected by methods set forth in Pestronk et al. (1980, Exp. Neurol. 70:65-82) or Brown et al. (1981, Ann. Rev. Neurosci. 4:1742); increased production of neuron-associated molecules may be measured by bioassay, enzymatic assay, antibody binding, Northern blot assay, etc., depending on the molecule to be measured; and motor neuron dysfunction may be measured by assessing the physical manifestation of motor neuron disorder, e.g., weakness, motor neuron conduction velocity, or functional disability. 
     In specific embodiments, motor neuron disorders that may be treated according to the invention include but are not limited to disorders such as infarction, infection, exposure to toxin, trauma, surgical damage, degenerative disease or malignancy that may affect motor neurons as well as other components of the nervous system, as well as disorders that selectively affect neurons such as amyotrophic lateral sclerosis, and including but not limited to progressive spinal muscular atrophy, progressive bulbar palsy, primary lateral sclerosis, infantile and juvenile muscular atrophy, progressive bulbar paralysis of childhood (Fazio-Londe syndrome), poliomyelitis and the post polio syndrome, and Hereditary Motorsensory Neuropathy (Charcot-Marie-Tooth Disease). 
     3.10.18 Other Activities 
     A polypeptide of the invention may also exhibit one or more of the following additional activities or effects: inhibiting the growth, infection or function of, or killing, infectious agents, including, without limitation, bacteria, viruses, fuingi and other parasites; effecting (suppressing or enhancing) bodily characteristics, including, without limitation, height, weight, hair color, eye color, skin, fat to lean ratio or other tissue pigrnentation, or organ or body part size or shape (such as, for example, breast augmentation or diminution, change in bone form or shape); effecting biorhythms or circadian cycles or rhythms; effecting the fertility of male or female subjects; effecting the metabolism, catabolism, anabolism, processing, utilization, storage or elimination of dietary fat, lipid, protein, carbohydrate, vitamins, minerals, co-factors or other nutritional factors or component(s); effecting behavioral characteristics, including, without limitation, appetite, libido, stress, cognition (including cognitive disorders), depression (including depressive disorders) and violent behaviors; providing analgesic effects or other pain reducing effects; promoting differentiation and growth of embryonic stem cells in lineages other than hematopoietic lineages; hormonal or endocrine activity; in the case of enzymes, correcting deficiencies of the enzyme and treating deficiency-related diseases; treatment of hyperproliferative disorders (such as, for example, psoriasis); immunoglobulin-like activity (such as, for example, the ability to bind antigens or complement); and the ability to act as an antigen in a vaccine composition to raise an immune response against such protein or another material or entity which is cross-reactive with such protein. 
     3.10.19 Identification of Polymorphisms 
     The demonstration of polymorphisms makes possible the identification of such polymorphisms in human subjects and the pharmacogenetic use of this information for diagnosis and treatment. Such polymorphisms may be associated with, e.g., differential predisposition or susceptibility to various disease states (such as disorders involving inflammation or immune response) or a differential response to drug admninistration, and this genetic information can be used to tailor preventive or therapeutic treatment appropriately. For example, the existence of a polymorphism associated with a predisposition to inflammation or autoimmune disease makes possible the diagnosis of this condition in humans by identifying the presence of the polymorphism. 
     Polymorphisms can be identified in a variety of ways known in the art which all generally involve obtaining a sample from a patient, analyzing DNA from the sample, optionally involving isolation or amplification of the DNA, and identifying the presence of the polymorphism in the DNA. For example, PCR may be used to amplify an appropriate fragment of genomic DNA which may then be sequenced. Alternatively, the DNA may be subjected to allele-specific oligonucleotide hybridization (in which appropriate oligonucleotides are hybridized to the DNA under conditions permitting detection of a single base mismatch) or to a single nucleotide extension assay (in which an oligonucleotide that hybridizes immediately adjacent to the position of the polymorphism is extended with one or more labeled nucleotides). In addition, traditional restriction fragment length polymorphism analysis (using restriction enzymes that provide differential digestion of the genomic DNA depending on the presence or absence of the polymorphism) may be performed. Arrays with nucleotide sequences of the present invention can be used to detect polymorphisms. The array can comprise modified nucleotide sequences of the present invention in order to detect the nucleotide sequences of the present invention. In the alternative, any one of the nucleotide sequences of the present invention can be placed on the array to detect changes from those sequences. 
     Alternatively a polymorphism resulting in a change in the amino acid sequence could also be detected by detecting a corresponding change in amino acid sequence of the protein, e.g., by an antibody specific to the variant sequence. 3.10.20 Arthritis and Inflammation 
     The immunosuppressive effects of the compositions of the invention against rheumatoid arthritis is determined in an experimental animal model system. The experimental model system is adjuvant induced arthritis in rats, and the protocol is described by J. Holoshitz, et at., 1983, Science, 219:56, or by B. Waksman et al., 1963, Int. Arch. Allergy Appl. Immunol., 23:129. Induction of the disease can be caused by a single injection, generally intradermally, of a suspension of killed Mycobacterium tuberculosis in complete Freund&#39;s adjuvant (CFA). The route of injection can vary, but rats may be injected at the base of the tail with an adjuvant mixture. The polypeptide is administered in phosphate buffered solution (PBS) at a dose of about 1-5 mg/kg. The control consists of administering PBS only. 
     The procedure for testing the effects of the test compound would consist of intradermally injecting killed Mycobacterium tuberculosis in CFA followed by immediately administering the test compound and subsequent treatment every other day until day 24. At 14, 15, 18, 20, 22, and 24 days after injection of Mycobacterium CFA, an overall arthritis score may be obtained as described by J. Holoskitz above. An analysis of the data would reveal that the test compound would have a dramatic affect on the swelling of the joints as measured by a decrease of the arthritis score. 
     3.11 Therapeutic Methods 
     The compositions (including polypeptide fragments, analogs, variants and antibodies or other binding partners or modulators including antisense polynucleotides) of the invention have numerous applications in a variety of therapeutic methods. Examples of therapeutic applications include, but are not limited to, those exemplified herein. 
     3.11.1 Example 
     One embodiment of the invention is the administration of an effective amount of the polypeptides or other composition of the invention to individuals affected by a disease or disorder that can be modulated by regulating the peptides of the invention. While the mode of administration is not particularly important, parenteral administration is preferred. An exemplary mode of administration is to deliver an intravenous bolus. The dosage of the polypeptides or other composition of the invention will normally be determined by the prescribing physician. It is to be expected that the dosage will vary according to the age, weight, condition and response of the individual patient. Typically, the amount of polypeptide administered per dose will be in the range of about 0.01 μg/kg to 100 mg/kg of body weight, with the preferred dose being about 0.1 μg/kg to 10 mg/kg of patient body weight. For parenteral administration, polypeptides of the invention will be formulated in an injectable form combined with a pharmaceutically acceptable parenteral vehicle. Such vehicles are well known in the art and examples include water, saline, Ringer&#39;s solution, dextrose solution, and solutions consisting of small amounts of the human serum albumin. The vehicle may contain minor amounts of additives that maintain the isotonicity and stability of the polypeptide or other active ingredient. The preparation of such solutions is within the slill of the art. 
     3.12 Pharmaceutical Formulations and Routes of Administration 
     A protein or other composition of the present invention (from whatever source derived, including without limitation from recombinant and non-recombinant sources and including antibodies and other binding partners of the polypeptides of the invention) may be administered to a patient in need, by itself, or in pharmaceutical compositions where it is mixed with suitable carriers or excipient(s) at doses to treat or ameliorate a variety of disorders. Such a composition may optionally contain (in addition to protein or other active ingredient and a carrier) diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials well known in the art. The term “pharmaceutically acceptable” means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredient(s). The characteristics of the carrier will depend on the route of administration. The pharmaceutical composition of the invention may also contain cytokines, lymphokines, or other hematopoietic factors such as M-CSF, GM-CSF, TNF, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IFN, TNF0, TNF1, TNF2, G-CSF, Meg-CSF, thrombopoietin, stem cell factor, and erythropoietin. In further compositions, proteins of the invention may be combined with other agents beneficial to the treatment of the disease or disorder in question. These agents include various growth factors such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factors (TGF-α and TGF-β), insulin-like growth factor (IGF), as well as cytokines described herein. 
     The pharmaceutical composition may further contain other agents which either enhance the activity of the protein or other active ingredient or complement its activity or use in treatment. Such additional factors and/or agents may be included in the pharmaceutical composition to produce a synergistic effect with protein or other active ingredient of the invention, or to minimize side effects. Conversely, protein or other active ingredient of the present invention may be included in formulations of the particular clotting factor, cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent to minimize side effects of the clotting factor, cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent (such as IL-1Ra, IL-1 Hy1, IL-1 Hy2, anti-TNF, corticosteroids, immunosuppressive agents). A protein of the present invention may be active in multimers (e.g., heterodimers or homodimers) or complexes with itself or other proteins. As a result, pharmaceutical compositions of the invention may comprise a protein of the invention in such multimeric or complexed form. 
     As an alternative to being included in a pharmaceutical composition of the invention including a first protein, a second protein or a therapeutic agent may be concurrently administered with the first protein (e.g., at the same time, or at differing times provided that therapeutic concentrations of the combination of agents is achieved at the treatment site). Techniques for formulation and administration of the compounds of the instant application may be found in “Remington&#39;s Pharmaceutical Sciences,” Mack Publishing Co., Easton, Pa., latest edition. A therapeutically effective dose further refers to that amount of the compound sufficient to result in amelioration of symptoms, e.g., treatment, healing, prevention or amelioration of the relevant medical condition, or an increase in rate of treatment, healing, prevention or amelioration of such conditions. When applied to an individual active ingredient, administered alone, a therapeutically effective dose refers to that ingredient alone. When applied to a combination, a therapeutically effective dose refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously. 
     In practicing the method of treatment or use of the present invention, a therapeutically effective amount of protein or other active ingredient of the present invention is administered to a mammal having a condition to be treated. Protein or other active ingredient of the present invention may be administered in accordance with the method of the invention either alone or in combination with other therapies such as treatments employing cytokines, lymphokines or other hematopoietic factors. When co-administered with one or more cytokines, lymphokines or other hematopoiefic factors, protein or other active ingredient of the present invention may be administered either simultaneously with the cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors, or sequentially. If administered sequentially, the attending physician will decide on the appropriate sequence of administering protein or other active ingredient of the present invention in combination with cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors. 
     3.12.1 Routes of Administration 
     Suitable routes of administration may, for example, include oral, rectal, transmucosal, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections. Administration of protein or other active ingredient of the present invention used in the pharmaceutical composition or to practice the method of the present invention can be carried out in a variety of conventional ways, such as oral ingestion, inhalation, topical application or cutaneous, subcutaneous, intraperitoneal, parenteral or intravenous injection. Intravenous administration to the patient is preferred. 
     Alternately, one may administer the compound in a local rather than systemic manner, for example, via injection of the compound directly into a arthritic joints or in fibrotic tissue, often in a depot or sustained release formulation. In order to prevent the scarring process frequently occurring as complication of glaucoma surgery, the compounds may be administered topically, for example, as eye drops. Furthermore, one may administer the drug in a targeted drug delivery system, for example, in a liposome coated with a specific antibody, targeting, for example, arthritic or fibrotic tissue. The liposomes will be targeted to and taken up selectively by the afflicted tissue. 
     The polypeptides of the invention are administered by any route that delivers an effective dosage to the desired site of action. The determination of a suitable route of administration and an effective dosage for a particular indication is within the level of skill in the art. Preferably for wound treatment, one administers the therapeutic compound directly to the site. Suitable dosage ranges for the polypeptides of the invention can be extrapolated from these dosages or from similar studies in appropriate animal models. Dosages can then be adjusted as necessary by the clinician to provide maximal therapeutic benefit. 
     3.12.2 Compositions/Formulations 
     Pharmaceutical compositions for use in accordance with the present invention thus may be formulated in a conventional manner using one or more physiologically acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. These pharmaceutical compositions may be manufactured in a manner that is itself known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. Proper formulation is dependent upon the route of administration chosen. When a therapeutically effective amount of protein or other active ingredient of the present invention is administered orally, protein or other active ingredient of the present invention will be in the form of a tablet, capsule, powder, solution or elixir. When administered in tablet forrm, the pharmaceutical composition of the invention may additionally contain a solid carrier such as a gelatin or an adjuvant. The tablet, capsule, and powder contain from about 5 to 95% protein or other active ingredient of the present invention, and preferably from about 25 to 90% protein or other active ingredient of the present invention. When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal or plant origin such as peanut oil, mineral oil, soybean oil, or sesame oil, or synthetic oils may be added. The liquid form of the pharmaceutical composition may bather contain physiological saline solution, dextrose or other saccharide solution, or glycols such as ethylene glycol, propylene glycol or polyethylene glycol. When administered in liquid form, the pharmaceutical composition contains from about 0.5 to 90% by weight of protein or other active ingredient of the present invention, and preferably from about 1 to 50% protein or other active ingredient of the present invention. 
     When a therapeutically effective amount of protein or other active ingredient of the present invention is administered by intravenous, cutaneous or subcutaneous injection, protein or other active ingredient of the present invention will be in the form of a pyrogen-free, parenterally acceptable aqueous solution. The preparation of such parenterally acceptable protein or other active ingredient solutions, having due regard to pH, isotonicity, stability, and the like, is within the skill in the art. A preferred pharmaceutical composition for intravenous, cutaneous, or subcutaneous injection should contain, in addition to protein or other active ingredient of the present invention, an isotonic vehicle such as Sodium Chloride Injection, Ringer&#39;s Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, Lactated Ringer&#39;s Injection, or other vehicle as known in the art. The pharmaceutical composition of the present invention may also contain stabilizers, preservatives, buffers, antioxidants, or other additives known to those of skill in the art. For injection, the agents of the invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks&#39;s solution, Ringer&#39;s solution, or physiological saline buffer. For tarsmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art. 
     For oral administration, the compounds can be formulated readily by combining the active compounds with pharmaceutically acceptable carriers well known in the art. Such carriers enable the compounds of the invention to be formulated as tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a patient to be treated. Pharmaceutical preparations for oral use can be obtained from a solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses. 
     Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added. All formulations for oral administration should be in dosages suitable for such administration. For buccal administration, the compositions may take the form of tablets or lozenges formulated in conventional manner. 
     For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebuliser, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of, e.g., gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. The compounds may be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents. 
     Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, suspensions of the active compounds may be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions. Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use. 
     The compounds may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides. In addition to the formulations described previously, the compounds may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt. 
     A pharmaceutical carrier for the hydrophobic compounds of the invention is a co-solvent system comprising benzyl alcohol, a nonpolar surfactant, a water-miscible organic polymer, and an aqueous phase. The co-solvent system may be the VPD co-solvent system. VPD is a solution of 3% w/v benzyl alcohol, 8% w/v of the nonpolar surfactant polysorbate 80, and 65% w/v polyethylene glycol 300, made up to volume in absolute ethanol. The VPD co-solvent system (VPD:5W) consists of VPD diluted 1:1 with a 5% dextrose in water solution. This co-solvent system dissolves hydrophobic compounds well, and itself produces low toxicity upon systemic administration. Naturally, the proportions of a co-solvent system may be varied considerably without destroying its solubility and toxicity characteristics. Furthermnore, the identity of the co-solvent components may be varied: for example, other low-toxicity nonpolar surfactants may be used instead of polysorbate 80; the fraction size of polyethylene glycol may be varied; other biocompatible polymers may replace polyethylene glycol, e.g. polyvinyl pyrrolidone; and other sugars or polysaccharides may substitute for dextrose. Alternatively, other delivery systems for hydrophobic pharmaceutical compounds may be employed. Liposomes and emulsions are well known examples of delivery vehicles or carriers for hydrophobic drugs. Certain organic solvents such as dimethylsulfoxide also may be employed, although usually at the cost of greater toxicity. Additionally, the compounds may be delivered using a sustained-release system, such as semipermeable matrices of solid hydrophobic polymers containing the therapeutic agent. Various types of sustained-release materials have been established and are well known by those skilled in the art. Sustained-release capsules may, depending on their chemical nature, release the compounds for a few weeks up to over 100 days. Depending on the chemical nature and the biological stability of the therapeutic reagent, additional strategies for protein or other active ingredient stabilization may be employed. 
     The pharmaceutical compositions also may comprise suitable solid or gel phase carriers or excipients. Examples of such carriers or excipients include but are not limited to calcium carbonate, calcium phosphate, various sugars, starches, cellulose derivatives, gelatin, and polymers such as polyethylene glycols. Many of the active ingredients of the invention may be provided as salts with pharmaceutically compatible counter ions. Such pharmaceutically acceptable base addition salts are those salts which retain the biological effectiveness and properties of the free acids and which are obtained by reaction with inorganic or organic bases such as sodium hydroxide, magnesium hydroxide, ammonia, trialkylamine, dialkylamine, monoalkylamine, dibasic amino acids, sodium acetate, potassium benzoate, triethanol amine and the like. 
     The pharmaceutical composition of the invention may be in the form of a complex of the protein(s) or other active ingredient(s) of present invention along with protein or peptide antigens. The protein and/or peptide antigen will deliver a stimulatory signal to both B and T lymphocytes. B lymphocytes will respond to antigen through their surface immunoglobulin receptor. T lymphocytes will respond to antigen through the T cell receptor (TCR) following presentation of the antigen by MHC proteins. MHC.and structurally related proteins including those encoded by class I and class II MHC genes on host cells will serve to present the peptide antigen(s) to T lymphocytes. The antigen components could also be supplied as purified MHC-peptide complexes alone or with co-stimulatory molecules that can directly signal T cells. Alternatively antibodies able to bind surface immunoglobulin and other molecules on B cells as well as antibodies able to bind the TCR and other molecules on T cells can be combined with the pharmaceutical composition of the invention 
     The pharmaceutical composition of the invention may be in the form of a liposome in which protein of the present invention is combined, in addition to other pharmaceutically acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form as micelles, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution. Suitable lipids for liposomal formulation include, without limitation, monoglycerides, diglycerides, sulfatides, lysolecithins, phospholipids, saponin, bile acids, and the like. Preparation of such liposomal formulations is within the level of skill in the art, as disclosed, for example, in U.S. Pat. Nos. 4,235,871; 4,501,728; 4,837,028; and 4,737,323, all of which are incorporated herein by reference. 
     The amount of protein or other active ingredient of the present invention in the pharmaceutical composition of the present invention will depend upon the nature and severity of the condition being treated, and on the nature of prior treatments which the patient has undergone. Ultimately, the attending physician will decide the amount of protein or other active ingredient of the present invention with which to treat each individual patient. Initially, the attending physician will administer low doses of protein or other active ingredient of the present invention and observe the patient&#39;s response. Larger doses of protein or other active ingredient of the present invention may be administered until the optimal therapeutic effect is obtained for the patient, and at that point the dosage is not increased further. It is contemplated that the various pharmaceutical compositions used to practice the method of the present invention should contain about 0.01 μg to about 100 mg (preferably about 0.1 μg to about 10 mg, more preferably about 0.1 μg to about 1 mg) of protein or other active ingredient of the present invention per kg body weight. For compositions of the present invention which are useful for bone, cartilage, tendon or ligament regeneration, the therapeutic method includes administering the composition topically, systematically, or locally as an implant or device. When administered, the therapeutic composition for use in this invention is, of course, in a pyrogen-free, physiologically acceptable form. Further, the composition may desirably be encapsulated or injected in a viscous form for delivery to the site of bone, cartilage or tissue damage. Topical administration may be suitable for wound healing and tissue repair. Therapeutically useful agents other than a protein or other active ingredient of the invention which may also optionally be included in the composition as described above, may alternatively or additionally, be administered simultaneously or sequentially with the composition in the methods of the invention. Preferably for bone and/or cartilage formation, the composition would include a matrix capable of delivering the protein-containing or other active ingredient-containing composition to the site of bone and/or cartilage damage, providing a structure for the developing bone and cartilage and optimally capable of being resorbed into the body. Such matrices may be formed of materials presently in use for other implanted medical applications. 
     The choice of matrix material is based on biocompatibility, biodegradability, mechanical properties, cosmetic appearance and interface properties. The particular application of the compositions will define the appropriate formulation. Potential matrices for the compositions may be biodegradable and chemically defined calcium sulfate, tricalcium phosphate, hydroxyapatite, polylactic acid, polyglycolic acid and polyanhydrides. Other potential materials are biodegradable and biologically well-defined, such as bone or dermal collagen. Further matrices are comprised of pure proteins or extracellular matrix components. Other potential matrices are nonbiodegradable and chemically defined, such as sintered hydroxyapatite, bioglass, aluminates, or other ceramics. Matrices may be comprised of combinations of any of the above mentioned types of material, such as polylactic acid and hydroxyapatite or collagen and tricalcium phosphate. The bioceramics may be altered in composition, such as in calcium-aluminate-phosphate and processing to alter pore size, particle size, particle shape, and biodegradability. Presently preferred is a 50:50 (mole weight) copolymer of lactic acid and glycolic acid in the form of porous particles having diameters ranging from 150 to 800 microns. In some applications, it will be useful to utilize a sequestering agent, such as carboxymethyl cellulose or autologous blood clot, to prevent the protein compositions from disassociating from the matrix. 
     A preferred family of sequestering agents is cellulosic materials such as alkylcelluloses (including hydroxyalkylcelluloses), including methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl-methylcellulose, and carboxymethylcellulose, the most preferred being cationic salts of carboxymethylcellulose (CMC). Other preferred sequestering agents include hyaluronic acid, sodium alginate, poly(ethylene glycol), polyoxyethylene oxide, carboxyvinyl polymer and poly(vinyl alcohol). The amount of sequestering agent useful herein is 0.5-20 wt %, preferably 1-10 wt % based on total formulation weight, which represents the amount necessary to prevent desorption of the protein from the polymer matrix and to provide appropriate handling of the composition, yet not so much that the progenitor cells are prevented from infiltrating the matrix, thereby providing the protein the opportunity to assist the osteogenic activity of the progenitor cells. In further compositions, proteins or other active ingredients of the invention may be combined with other agents beneficial to the treatment of the bone and/or cartilage defect, wound, or tissue in question. These agents include various growth factors such as epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factors (TGF-α and TGF-β), and insulin-like growth factor (IGF). 
     The therapeutic compositions are also presently valuable for veterinary applications. Particularly domestic animals and thoroughbred horses, in addition to humans, are desired patients for such treatment with proteins or other active ingredients of the present invention. The dosage regimen of a protein-containing pharmaceutical composition to be used in tissue regeneration will be determined by the attending physician considering various factors which modify the action of the proteins, e.g., amount of tissue weight desired to be formed, the site of damage, the condition of the damaged tissue, the size of a wound, type of damaged tissue (e.g., bone), the patient&#39;s age, sex, and diet, the severity of any infection, time of administration and other clinical factors. The dosage may vary with the type of matrix used in the reconstitution and with inclusion of other proteins in the pharmaceutical composition. For example, the addition of other known growth factors, such as IGF I (insulin like growth factor I), to the final composition, may also effect the dosage. Progress can be monitored by periodic assessment of tissue/bone growth and/or repair, for example, X-rays, histomorphometric determinations and tetracycline labeling. 
     Polynucleotides of the present invention can also be used for gene therapy. Such polynucleotides can be introduced either in vivo or ex vivo into cells for expression in a mammalian subject. Polynucleotides of the invention may also be administered by other known methods for introduction of nucleic acid into a cell or organism (including, without limitation, in the form of viral vectors or naked DNA). Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic purposes. 
     3.12.3 Effective Dosage 
     Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in an effective amount to achieve its intended purpose. More specifically, a therapeutically effective amount means an amount effective to prevent development of or to alleviate the existing symptoms of the subject being treated. Determination of the effective amount is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from appropriate in vitro assays. For example, a dose can be formulated in animal models to achieve a circulating concentration range that can be used to more accurately determine useful doses in humans. For example, a dose can be formulated in animal models to achieve a circulating concentration range that includes the IC 50  as determined in cell culture (i.e., the concentration of the test compound which achieves a half-maximal inhibition of the protein&#39;s biological activity). Such information can be used to more accurately determine useful doses in humans. 
     A therapeutically effective dose refers to that amount of the compound that results in amelioration of symptoms or a prolongation of survival in a patient. Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD 50  (the dose lethal to 50% of the population) and the ED 50  (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio between LD 50  and ED 50 . Compounds which exhibit high therapeutic indices are preferred. The data obtained from these cell culture assays and animal studiescan be used in formulating a range of dosage for use in human. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED 50  with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. The exact formulation, route of administration and dosage can be chosen by the individual physician in view of the patient&#39;s condition. See, e.g., Fingl et al., 1975, in “The Pharmacological Basis of Therapeutics”, Ch. 1 p.1. Dosage amount and interval may be adjusted individually to provide plasma levels of the active moiety which are sufficient to maintain the desired effects, or minimal effective concentration (MEC). The MEC will vary for each compound but can be estimated from in vitro data Dosages necessary to achieve the MEC will depend on individual characteristics and route of administration. However, HPLC assays or bioassays can be used to determine plasma concentrations. 
     Dosage intervals can also be determined using MEC value. Compounds should be administered using a regimen which maintains plasma levels above the MEC for 10-90% of the time, preferably between 30-90% and most preferably between 50-90%. In cases of local administration or selective uptake, the effective local concentration of the drug may not be related to plasma concentration. 
     An exemplary dosage regimen for polypeptides or other compositions of the invention will be in the range of about 0.01 μg/kg to 100 mg/kg of body weight daily, with the preferred dose being about 0.1 μg/kg to 25 mg/kg of patient body weight daily, varying in adults and children. Dosing may be once daily, or equivalent doses may be delivered at longer or shorter intervals. 
     The amount of composition administered will, of course, be dependent on the subject being treated, on the subject&#39;s age and weight, the severity of the affliction, the manner of administration and the judgment of the prescribing physician. 
     3.12.4 Packaging 
     The compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient. The pack may, for example, comprise metal or plastic foil, such as a blister pack. The pack or dispenser device may be accompanied by instructions for administration. Compositions comprising a compound of the invention formulated in a compatible pharmaceutical carrier may also be prepared, placed in an appropriate container, and labeled for treatment of an indicated condition. 
     3.13 Antibodies 
     Also included in the invention are antibodies to proteins, or fragments of proteins of the invention. The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin (Ig) molecules, i.e., molecules that contain an antigen-binding site that specifically binds (immunoreacts with) an antigen. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, F ab , F ab′  and F (ab′)2  fragments, and an F ab  expression library. In general, an antibody molecule obtained from humans relates to any of the classes IgG, IgM, IgA, IgE and IgD, which differ from one another by the nature of the heavy chain present in the molecule. Certain classes have subclasses as well, such as IgG 1 , IgG 2 , and others. Furthermore, in humans, the light chain may be a kappa chain or a lambda chain. Reference herein to antibodies includes a reference to all such classes, subclasses and types of human antibody species. 
     An isolated related protein of the invention may be intended to serve as an antigen, or a portion or fragment thereof, and additionally can be used as an immunogen to generate antibodies that inmmunospecifically bind the antigen, using standard techniques for polyclonal and monoclonal antibody preparation. The full-length protein can be used or, alternatively, the invention provides antigenic peptide fragments of the antigen for use as immunogens. An antigenic peptide fragment comprises at least 6 mino acid residues of the amino acid sequence of the full length protein, such as an amino acid sequence shown in SEQ ID NO: 1-948, and encompasses an epitope thereof such that an antibody raised against the peptide forms a specific immune complex with the full length protein or with any fragment that contains the epitope. Preferably, the antigenic peptide comprises at least 10 amino acid residues, or at least 15 amino acid residues, or at least 20 amino acid residues, or at least 30 amino acid residues. Preferred epitopes encompassed by the antigenic peptide are regions of the protein that are located on its surface; commonly these are hydrophilic regions. 
     In certain embodiments of the invention, at least one epitope encompassed by the antigenic peptide is a region of alpha-2-macroglobulin-like protein that is located on the surface of the protein, e.g., a hydrophilic region. A hydrophobicity analysis of the human related protein sequence will indicate which regions of a related protein are particularly hydrophilic and, therefore, are likely to encode surface residues useful for targeting antibody production. As a means for targeting antibody production, hydropathy plots showing regions of hydrophilicity and hydrophobicity may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, 1981 , Proc. Nat. Acad. Sci. USA  78: 3824-3828; Kyte and Doolittle 1982 , J. Mol. Biol . 157: 105-142, each of which is incorporated herein by reference in its entirety. Antibodies that are specific for one or more domains within an antigenic protein, or derivatives, fragments, analogs or homologs thereof, are also provided herein. 
     A protein of the invention, or a derivative, fragment, analog, homolog or ortholog thereof, may be utilized as an immunogen in the generation of antibodies that immunospecifically bind these protein components. 
     The term “specific for” indicates that the variable regions of the antibodies of the invention recognize and bind polypeptides of the invention exclusively (i.e., able to distinguish the polypeptide of the invention from other similar polypeptides despite sequence identity, homology, or similarity found in the family of polypeptides), but may also interact with other proteins (for example,  S. aureus  protein A or other antibodies in ELISA techniques) through interactions with sequences outside the variable region of the antibodies, and in particular, in the constant region of the molecule. Screening assays to determine binding specificity of an antibody of the invention are well known and routinely practiced in the art. For a comprehensive discussion of such assays, see Harlow et al. (Eds), Antibodies A Laboratory Manual; Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. (1988), Chapter 6. Antibodies that recognize and bind fragments of the polypeptides of the invention are also contemplated, provided that the antibodies are first and foremost specific for, as defined above, full-length polypeptides of the invention. As with antibodies that are specific for full length polypeptides of the invention, antibodies of the invention that recognize fragments are those which can distinguish polypeptides from the same family of polypeptides despite inherent sequence identity, homology, or similarity found in the family of proteins. 
     Antibodies of the invention are useful for, for example, therapeutic purposes (by modulating activity of a polypeptide of the invention), diagnostic purposes to detect or quantitate a polypeptide of the invention, as well as purification of a polypeptide of the invention. Kits comprising an antibody of the invention for any of the purposes described herein are also comprehended. In general, a kit of the invention also includes a control antigen for which the antibody is immunospecific. The invention further provides a hybridoma that produces an antibody according to the invention. Antibodies of the invention are useful for detection and/or purification of the polypeptides of the invention. 
     Monoclonal antibodies binding to the protein of the invention may be useful diagnostic agents for the immunodetection of the protein. Neutralizing monoclonal antibodies binding to the protein may also be useful therapeutics for both conditions associated with the protein and also in the treatment of some forms of cancer where abnormal expression of the protein is involved. In the case of cancerous cells or leukemic cells, neutralizing monoclonal antibodies against the protein may be useful in detecting and preventing the metastatic spread of the cancerous cells, which may be mediated by the protein. 
     The labeled antibodies of the present invention can be used for in vitro, in vivo, and in situ assays to identify cells or tissues in which a fragment of the polypeptide of interest is expressed. The antibodies may also be used directly in therapies or other diagnostics. The present invention further provides the above-described antibodies immobilized on a solid support. Examples of such solid supports include plastics such as polycarbonate, complex carbohydrates such as agarose and Sepharose®, acrylic resins and such as polyacrylamide and latex beads. Techniques for coupling antibodies to such solid supports are well known in the art (Weir, D. M. et al., “Handbook of Experimental Immunology” 4th Ed., Blackwell Scientific Publications, Oxford, England, Chapter 10 (1986); Jacoby, W. D. et al., Meth. Enzym. 34 Academic Press, N.Y. (1974)). The immobilized antibodies of the present invention can be used for in vitro, in vivo, and in situ assays as well as for immuno-affinity purification of the proteins of the present invention. 
     Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies directed against a protein of the invention, or against derivatives, fragments, analogs homologs or orthologs thereof (see, for example, Antibodies: A Laboratory Manual, Harlow E, and Lane D, 1988, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., incorporated herein by reference). Some of these antibodies are discussed below. 
     3.13.1 Polyclonal Antibodies 
     For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by one or more injections with the native protein, a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, the naturally occurring immunogenic protein, a chemically synthesized polypeptide representing the immunogenic protein, or a recombinantly expressed immunogenic protein. Furthermore, the protein may be conjugated to a second protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund&#39;s (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface-active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), adjuvants usable in humans such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. Additional examples of adjuvants that can be employed include MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). 
     The polyclonal antibody molecules directed against the immunogenic protein can be isolated from the manmmal (e.g., from the blood) and further purified by well known techniques, such as affinity chromatography using protein A or protein G, which provide primarily the IgG faction of immune serum. Subsequently, or alternatively, the specific antigen which is the target of the immunoglobulin sought, or an epitope thereof, may be immobilized on a column to purify the immune specific antibody by immunoaffinity chromatography. Purification of inmmunoglobulins is discussed, for example, by D. Wilkinson (The Scientist, published by The Scientist, Inc., Philadelphia Pa., Vol. 14, No. 8 (Apr. 17, 2000), pp. 25-28). 
     3.13.2 Monoclonal Antibodies 
     The term “monoclonal antibody” (MAb) or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one molecular species of antibody molecule consisting of a unique light chain gene product and a unique heavy chain gene product. In particular, the complementarity determining regions (CDRs) of the monoclonal antibody are identical in all the molecules of the population. MAbs thus contain an antigen-binding site capable of immunoreacting with a particular epitope of the antigen characterized by a unique binding affinity for it. 
     Monoclonal antibodies can be prepared using hybridoma methods, such as those described by Kohler and Milstein,  Nature , 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes can be immunized in vitro. 
     The immunizing agent will typically include the protein antigen, a fragment thereof or a fusion protein thereof. Generally, either peripheral blood lymphocytes are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding,  Monoclonal Antibodies: Principles and Practice , Academic Press, (1986) pp. 59-103). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells can be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells. 
     Preferred immortalized cell lines are those that fuse efficiently, support stable high level expression of antibody by the selected antibody-producing cells, and are sensitive to a medium such as HAT medium. More preferred immortalized cell lines are murine myeloma lines, which can be obtained, for instance, from the Salk Institute Cell Distribution Center, San Diego, Calif. and the American Type Culture Collection, Manassas, Va. Human myeloma and mouse-human heteromyeloma cell lines also have been described for the production of human monoclonal antibodies (Kozbor,  J. Immunol ., 133:3001 (1984); Brodeur et al.,  Monoclonal Antibody Production Techniques and Applications , Marcel Dekker, Inc., New York, (1987) pp. 51-63). 
     The culture medium in which the hybridoma cells are cultured can then be assayed for the presence of monoclonal antibodies directed against the antigen. Preferably, the binding specificity of monoclonal antibodies produced by the hybridoma cells is determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA). Such techniques and assays are known in the art. The binding affinity of the monoclonal antibody can, for example, be determined by the Scatchard analysis of Munson and Pollard,  Anal. Biochem ., 107:220 (1980). Preferably, antibodies having a high degree of specificity and a high binding affinity for the target antigen are isolated. 
     After the desired hybridoma cells are identified, the clones can be subcloned by limiting dilution procedures and grown by standard methods. Suitable culture media for this purpose include, for example, Dulbecco&#39;s Modified Eagle&#39;s Medium and RPMI-1640 medium. Alternatively, the hybridoma cells can be grown in vivo as ascites in a mammal. 
     The monoclonal antibodies secreted by the subclones can be isolated or purified from the culture medium or ascites fluid by conventional immunoglobulin purification procedures such as, for example, protein A-Sepharose, hydroxylapatite chromatography, gel electrophoresis, dialysis, or affinity chromatography. 
     The monoclonal antibodies can also be made by recombinant DNA methods, such as those described in U.S. Pat. No. 4,816,567. DNA encoding the monoclonal antibodies of the invention can be readily isolated and sequenced using conventional procedures (e.g., by using oligonucleotide probes that are capable of binding specifically to genes encoding the heavy and light chains of murine antibodies). The hybridoma cells of the invention serve as a preferred source of such DNA. Once isolated, the DNA can be placed into expression vectors, which are then transfected into host cells such as simian COS cells, Chinese hamster ovary (CHO) cells, or myeloma cells that do not otherwise produce immunoglobulin protein, to obtain the synthesis of monoclonal antibodies in the recombinant host cells. The DNA also can be modified, for example, by substituting the coding sequence for human heavy and light chain constant domains in place of the homologous murine sequences (U.S. Pat. No. 4,816,567; Morrison,  Nature  368, 812-13 (1994)) or by covalently joining to the immunoglobulin coding sequence all or part of the coding sequence for a non-immunoglobulin polypeptide. Such a non-immunoglobulin polypeptide can be substituted for the constant domains of an antibody of the invention, or can be substituted for the variable domains of one antigen-combining site of an antibody of the invention to create a chimeric bivalent antibody. 
     3.13.3 Humanized Antibodies 
     The antibodies directed against the protein antigens of the invention can further comprise humanized antibodies or human antibodies. These antibodies are suitable for administration to humans without engendering an immune response by the human against the administered immunoglobulin. Humanized forms of antibodies are chimeric immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab′, F(ab′) 2  or other antigen-binding subsequences of antibodies) that are principally comprised of the sequence of a human immunoglobulin, and contain minimal sequence derived from a non-human immunoglobulin. Humanization can be performed following the method of Winter and co-workers (Jones et al.,  Nature , 321:522-525 (1986); Riechmann et al.,  Nature , 332:323-327 (1988); Verhoeyen et al.,  Science , 239:1534-1536 (1988)), by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. (See also U.S. Pat. No. 5,225,539). In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies can also comprise residues that are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones et al., 1986; Riechmann et al., 1988; and Presta,  Curr. Op. Struct. Biol ., 2:593-596 (1992)). 
     3.13.4 Human Antibodies 
     Fully human antibodies relate to antibody molecules in which essentially the entire sequences of both the light chain and the heavy chain, including the CDRs, arise from human genes. Such antibodies are termed “human antibodies”, or “fully human antibodies” herein. Human monoclonal antibodies can be prepared by the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., 1983 Immunol Today 4: 72) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: M ONOCLONAL  A NTIBODIES AND  C ANCER  T HERAPY , Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., 1983. Proc Natl Acad Sci USA 80: 2026-2030) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., 1985 In: M ONOCLONAL  A NTIBODIES AND  C ANCER  T HERAPY , Alan R. Liss, Inc., pp. 77-96). 
     In addition, human antibodies can also be produced using additional techniques, including phage display libraries (Hoogenboom and Winter,  J. Mol. Biol ., 227:381 (1991); Marks et al.,  J. Mol. Biol ., 222:581 (1991)). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in Marks et al. ( Bio/Technology  10, 779-783 (1992)); Lonberg et al. ( Nature  368 856-859 (1994)); Morrison (Nature 368, 812-13 (1994)); Fishwild et al, ( Nature Biotechnology  14, 845-51 (1996)); Neuberger ( Nature Biotechnology  14, 826 (1996)); and Lonberg and Huszar ( Intern. Rev. Immunol . 13 65-93 (1995)). 
     Human antibodies may additionally be produced using taansgenic nonhuman animals that are modified so as to produce fully human antibodies rather than the animal&#39;s endogenous antibodies in response to challenge by an antigen. (See PCT publication WO94/02602). The endogenous genes encoding the heavy and light immunoglobulin chains in the nonhuman host have been incapacitated, and active loci encoding human heavy and light chain immunoglobulins are inserted into the host&#39;s genome. The human genes are incorporated, for example, using yeast artificial chromosomes containing the requisite human DNA segments. An animal which provides all the desired modifications is then obtained as progeny by crossbreeding intermediate transgenic animals containing fewer than the full complement of the modifications. The preferred embodiment of such a nonhuman animal is a mouse, and is termed the Xenomouse™ as disclosed in PCT publications WO 96/33735 and WO 96/34096. This animal produces B cells that secrete fully human immunoglobulins. The antibodies can be obtained directly from the animal after immunization with an immunogen of interest, as, for example, a preparation of a polyclonal antibody, or alternatively from immortalized B cells derived from the animal, such as hybridomas producing monoclonal antibodies. Additionally, the genes encoding the immunoglobulins with human variable regions can be recovered and expressed to obtain the antibodies directly, or can be further modified to obtain analogs of antibodies such as, for example, single chain Fv molecules. 
     An example of a method of producing a nonhuman host, exemplified as a mouse, lacking expression of an endogenous immunoglobulin heavy chain is disclosed in U.S. Pat. No. 5,939,598. It can be obtained by a method including deleting the J segment genes from at least one endogenous heavy chain locus in an embryonic stem cell to prevent rearrangement of the locus and to prevent formation of a transcript of a rearranged immunoglobulin heavy chain locus, the deletion being effected by a targeting vector containing a gene encoding a selectable marker; and producing from the embryonic stem cell a transgenic mouse whose somatic and germ cells contain the gene encoding the selectable marker. 
     A method for producing an antibody of interest, such as a human antibody, is disclosed in U.S. Pat. No. 5,916,771. It includes introducing an expression vector that contains a nucleotide sequence encoding a heavy chain into one mammalian host cell in culture, introducing an expression vector containing a nucleotide sequence encoding a light chain into another mammalian host cell, and fusing the two cells to form a hybrid cell. The hybrid cell expresses an antibody containing the heavy chain and the light chain. 
     In a further improvement on this procedure, a method for identifying a clinically relevant epitope on an imnmunogen, and a correlative method for selecting an antibody that binds immunospecifically to the relevant epitope with high affinity, are disclosed in PCT publication WO 99/53049. 
     3.13.5 Fab Fragments and Single Chain Antibodies 
     According to the invention, techniques can be adapted for the production of single-chain antibodies specific to an antigenic protein of the invention (see e.g., U.S. Pat. No. 4,946,778). In addition, methods can be adapted for the construction of F ab  expression libraries (see e.g., Huse, et al., 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal F ab  fragments with the desired specificity for a protein or derivatives, fragments, analogs or homologs thereof. Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, but not limited to: (i) an F (ab′)2  fragment produced by pepsin digestion of an antibody molecule; (ii) an F ab  fragment generated by reducing the disulfide bridges of an F (ab′)2  fragment; (iii) an F ab  fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F v  fragments. 
     3.13.6 Bispecific Antibodies 
     Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for an antigenic protein of the invention. The second binding target is any other antigen, and advantageously is a cell-surface protein or receptor or receptor subunit. 
     Methods for making bispecific antibodies are known in the art. Traditionally, the recombinant production of bispecific antibodies is based on the co-exprcssion of two immunoglobulin heavyhain/light-chain pairs, where the two heavy chains have different specificities (Milstein and Cuello,  Nature , 305:537-539 (1983)). Because of the random assortment of immunoglobulin heavy and light chains, these hybridomas (quadromas) produce a potential mixture of ten different antibody molecules, of which only one has the correct bispecific structure. The purification of the correct molecule is usually accomplished by affinity chromatography steps. Similar procedures are disclosed in WO 93/08829, published 13 May 1993, and in Traunecker et al., 1991  EMBO J ., 10:3655-3659. 
     Antibody variable domains with the desired binding specificities (antibody-antigen combining sites) can be fused to immunoglobulin constant domain sequences. The fusion preferably is with an immunoglobulin heavy-chain constant domain, comprising at least part of the hinge, CH2, and CH3 regions. It is preferred to have the first heavy-chain constant region (CH1) containing the site necessary for light-chain binding present in at least one of the fusions. DNAs encoding the immunoglobulin heavy-chain fusions and, if desired, the immunoglobulin light chain, are inserted into separate expression vectors, and are co-transfected into a suitable host organism. For further details of generating bispecific antibodies see, for example, Suresh et al.,  Methods in Enzymology , 121:210 (1986). 
     According to another approach described in WO 96/27011, the interface between a pair of antibody molecules can be engineered to maximize the percentage of heterodimers that are recovered from recombinant cell culture. The preferred interface comprises at least a part of the CH3 region of an antibody constant domain. In this method, one or more small amino acid side chains from the interface of the first antibody molecule are replaced with larger side chains (e.g. tyrosine or tryptophan). Compensatory “cavities” of identical or similar size to the large side chain(s) are created on the interface of the second antibody molecule by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). This provides a mechanism for increasing the yield of the heterodimer over other unwanted end-products such as homodimers. 
     Bispecific antibodies can be prepared as full length antibodies or antibody fragments (e.g. F(ab′) 2  bispecific antibodies). Techniques for generating bispecific antibodies from antibody fragments have been described in the literature. For example, bispecific antibodies can be prepared using chemical linkage. Brennan et al.,  Science  229:81 (1985) describe a procedure wherein intact antibodies are proteolytically cleaved to generate F(ab′) 2  fragments. These fragments are reduced in the presence of the dithiol complexing agent sodium arsenite to stabilize vicinal dithiols and prevent intermolecular disulfide formation. The Fab′ fragments generated are then converted to thionitrobenzoate (TNB) derivatives. One of the Fab′-TNB derivatives is then reconverted to the Fab′-thiol by reduction with mercaptoethylamine and is mixed with an equimolar amount of the other Fab′-TNB derivative to form the bispecific antibody. The bispecific antibodies produced can be used as agents for the selective immobilization of enzymes. 
     Additionally, Fab′ fragments can be directly recovered from  E. coli  and chemically coupled to form bispecific antibodies. Shalaby et al.,  J. Exp. Med . 175:217-225 (1992) describe the production of a fully humanized bispecific antibody F(ab′) 2  molecule. Each Fab′ fragment was separately secreted from  E. coli  and subjected to directed chemical coupling in vitro to form the bispecific antibody. The bispecific antibody thus formed was able to bind to cells overexpressing the ErbB2 receptor and normal human T cells, as well as trigger the lytic activity of human cytotoxic lymphocytes against human breast tumor targets. 
     Various techniques for making and isolating bispecific antibody fragments directly from recombinant cell culture have also been described. For example, bispecific antibodies have been produced using leucine zippers. Kostelny et al.,  J. Immunol . 148(5):1547-1553 (1992). The leucine zipper peptides from the Fos and Jun proteins were linked to the Fab′ portions of two different antibodies by gene fusion. The antibody homodimers were reduced at the hinge region to form monomers and then re-oxidized to form the antibody heterodimers. This method can also be utilized for the production of antibody homodimers. The “diabody” technology described by Hollinger et al.,  Proc. Natl. Acad. Sci. USA  90:6444-6448 (1993) has provided an alternative mechanism for making bispecific antibody fragments. The fragments comprise a heavy-chain variable domain (V H ) connected to a lighthain variable domain (V L ) by a linker which is too short to allow pairing between the two domains on the same chain. Accordingly, the V H  and V L  domains of one fragment are forced to pair with the complementary V L  and V H  domains of another fragment, thereby forming two antigen-binding sites. Another strategy for making bispecific antibody fragments by the use of single-chain Fv (sFv) dimers has also been reported. See, Gruber et al.,  J. Immunol . 152:5368 (1994). 
     Antibodies with more than two valencies are contemplated. For example, trispecific antibodies can be prepared. Tutt et al.,  J. Immunol . 147:60 (1991). 
     Exemplary bispecific antibodies can bind to two different epitopes, at least one of which originates in the protein antigen of the invention. Alternatively, an anti-antigenic arm of an immunoglobulin molecule can be combined with an arm which binds to a triggering molecule on a leukocyte such as a T-cell receptor molecule (e.g. CD2, CD3, CD28, or B7), or Fc receptors for IgG (Fc R), such as Fc RI (CD64), Fe RII (CD32) and Fc RIII (CD16) so as to focus cellular defense mechanisms to the cell expressing the particular antigen. Bispecific antibodies can also be used to direct cytotoxic agents to cells which express a particular antigen. These antibodies possess an antigen-binding arm and an arm which binds a cytotoxic agent or a radionuclide chelator, such as EOTUBE, DPTA, DOTA, or TETA. Another bispecific antibody of interest binds the protein antigen described herein and further binds tissue factor TF). 
     3.13.7 Heteroconjugate Antibodies 
     Heteroconjugate antibodies are also within the scope of the present invention. Heteroconjugate antibodies are composed of two covalently joined antibodies. Such antibodies have, for example, been proposed to target immune system cells to unwanted cells (U.S. Pat. No. 4,676,980), and for treatment of HIV infection (WO 91/00360; WO 92/200373; EP 03089). It is contemplated that the antibodies can be prepared in vitro using known methods in synthetic protein chemistry, including those involving crosslinking agents. For example, immunotoxins can be constructed using a disulfide exchange reaction or by forming a thioether bond. Examples of suitable reagents for this purpose include iminothiolate and methyl-4-mercaptobutyrimidate and those disclosed, for example, in U.S. Pat. No. 4,676,980. 
     3.13.8 Effector Function Engineering 
     It can be desirable to modify the antibody of the invention with respect to effector function, so as to enhance, e.g., the effectiveness of the antibody in treating cancer. For example, cysteine residue(s) can be introduced into the Fe region, thereby allowing interchain disulfide bond formation in this region. The homodimeric antibody thus generated can have improved internalization capability and/or increased complement-mediated cell killing and antibody-dependent cellular cytotoxicity (ADCC). See Caron et al., J. Exp Med., 176: 1191-1195 (1992) and Shopes, J. Imunol., 148: 2918-2922 (1992). Homodimeric antibodies with enhanced anti-tumor activity can also be prepared using heterobifunctional cross-linkers as described in Wolff et al. Cancer Research, 53: 2560-2565 (1993). Alternatively, an antibody can be engineered that has dual Fc regions and can thereby have enhanced complement lysis and ADCC capabilities. See Stevenson et al., Anti-Cancer Drug Design, 3: 219-230 (1989). 
     3.13.9 Immunoconjugates 
     The invention also pertains to immunoconjugates comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, or animal origin, or fragments thereof), or a radioactive isotope (i.e., a radioconjugate). 
     Chemotherapeutic agents useful in the generation of such immunoconjugates have been described above. Enzymatically active toxins and fragments thereof that can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from Pseudomonas aeruginosa), ricin A chain, abrin A chain, modeccin A chain, alpha-sarcin, Aleurites fordii proteins, dianthin proteins, Phytolaca americana proteins (PAPI, PAPII, and PAP-S), momordica charantia inhibitor, curcin, crotin, sapaonaria officinalis inhibitor, gelonin, mitogellin, restrictocin, phenomycin, enomycin, and the tricothecenes. A variety of radionuclides are available for the production of radioconjugated antibodies. Examples include  212 Bi,  131 I,  131 In,  90 y, and  186 Re. 
     Conjugates of the antibody and cytotoxic agent are made using a variety of bifunctional protein-coupling agents such as N-succinimidyl-3-(2-pyridyldithiol) propionate (SPDP), iminothiolane (IT), bifunctional derivatives of imidoesters (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutareldehyde), bis-azido compounds (such as bis (pazidobenzoyl) hexanediamine), bis-diazonium derivatives (such as bis-(p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as tolyene 2,6-diisocyanate), and bis-active fluorine compounds (such as 1,5-difluoro-2,4-dinitrobenzene). For example, a ricin immunotoxin can be prepared as described in Vitetta et al., Science, 238: 1098 (1987). Carbon-14-labeled 1-isothiocyanatobenzyl-3-methyldiethylene triaminepentaacetic acid (MX-DTPA) is an exemplary chelating agent for conjugation of radionucleotide to the antibody. See WO94/11026. 
     In another embodiment, the antibody can be conjugated to a “receptor” (such streptavidin) for utilization in tumor pretargeting wherein the antibody-receptor conjugate is administered to the patient, followed by removal of unbound conjugate from the circulation using a clearing agent and then administration of a “ligand” (e.g., avidin) that is in turn conjugated to a cytotoxic agent. 
     3.14 Computer Readable Sequences 
     In one application of this embodiment, a nucleotide sequence of the present invention can be recorded on computer readable media. As used herein, “computer readable media” refers to any medium which can be read and accessed directly by a computer. Such media include, but are not limited to: magnetic storage media, such as floppy discs, hard disc storage medium, and magnetic tape; optical storage media such as CD-ROM; electrical storage media such as RAM and ROM; and hybrids of these categories such as magnetic/optical storage media. A skilled artisan can readily appreciate how any of the presently known computer readable mediums can be used to create a manufacture comprising computer readable medium having recorded thereon a nucleotide sequence of the present invention. As used herein, “recorded” refers to a process for storing information on computer readable medium. A skilled artisan can readily adopt any of the presently known methods for recording information on computer readable medium to generate manufactures comprising the nucleotide sequence information of the present invention. 
     A variety of data storage structures are available to a skilled artisan for creating a computer readable medium having recorded thereon a nucleotide sequence of the present invention. The choice of the data storage structure will generally be based on the means chosen to access the stored information. In addition, a variety of data processor programs and formats can be used to store the nucleotide sequence information of the present invention on computer readable medium. The sequence information can be represented in a word processing text file, formatted in commercially-available software such as WordPerfect and Microsoft Word, or represented in the form of an ASCII file, stored in a database application, such as DB2, Sybase, Oracle, or the like. A skilled artisan can readily adapt any number of data processor structuring formats (e.g. text file or database) in order to obtain computer readable medium having recorded thereon the nucleotide sequence information of the present invention. 
     By providing any of the nucleotide sequences SEQ ID NOs: 1-948 or a representative fragment thereof; or a nucleotide sequence at least 95% identical to any of the nucleotide sequences of SEQ ID NOs: 1-948 in computer readable form, a skilled artisan can routinely access the sequence information for a variety of purposes. Computer software is publicly available which allows a skilled artisan to access sequence information provided in a computer readable medium. The examples which follow demonstrate how software which implements the BLAST (Altschul et al., J. Mol. Biol. 215:403-410 (1990)) and BLAZE (Brutlag et al., Comp. Chem. 17:203-207 (1993)) search algorithms on a Sybase system is used to identify open reading frames (ORFs) within a nucleic acid sequence. Such ORFs may be protein encoding fragments and may be useful in producing commercially important proteins such as enzymes used in fermentation reactions and in the production of commercially useful metabolites. 
     As used herein, “a computer-based system” refers to the hardware means, software means, and data storage means used to analyze the nucleotide sequence information of the present invention. The minimum hardware means of the computer-based systems of the present invention comprises a central processing unit (CPU), input means, output means, and data storage means. A skilled artisan can readily appreciate that any one of the currently available computer-based systems are suitable for use in the present invention. As stated above, the computer-based systems of the present invention comprise a data storage means having stored therein a nucleotide sequence of the present invention and the necessary hardware means and software means for supporting and implementing a search means. As used herein, “data storage means” refers to memory which can store nucleotide sequence information of the present invention, or a memory access means which can access manufactures having recorded thereon the nucleotide sequence information of the present invention. 
     As used herein, “search means” refers to one or more programs which are implemented on the computer-based system to compare a target sequence or target structural motif with the sequence information stored within the data storage means. Scarch means are used to identify fragments or regions of a known sequence which match a particular target sequence or target motif A variety of known algorithms are disclosed publicly and a variety of commercially available software for conducting search means are and can be used in the computer-based systems of the present invention. Examples of such software includes, but is not limited to, Smnith-Waterman, MacPattern (EMBL), BLASTN and BLASTA (NPOLYPEPTIDEIA). A skilled artisan can readily recognize that any one of the available algorithms or implementing software packages for conducting homology searches can be adapted for use in the present computer-based systems. As used herein, a “target sequence” can be any nucleic acid or amino acid sequence of six or more nucleotides or two or more amino acids. A skilled artisan can readily recognize that the longer a target sequence is, the less likely a target sequence will be present as a random occurrence in the database. The most preferred sequence length of a target sequence is from about 10 to 300 amino acids, more preferably from about 30 to 100 nucleotide residues. However, it is well recognized that searches for commercially important fragments, such as sequence fragments involved in gene expression and protein processing, may be of shorter length. 
     As used herein, “a target structural motif,” or “target motif,” refers to any rationally selected sequence or combination of sequences in which the sequence(s) are chosen based on a three-dimensional configuration which is formed upon the folding of the target motif. There are a variety of target motifs known in the art. Protein target motifs include, but are not limited to, enzyme active sites and signal sequences. Nucleic acid target motifs include, but are not limited to, promoter sequences, hairpin structures and inducible expression elements (protein binding sequences). 
     3.15 Triple Helix Formation 
     In addition, the fragments of the present invention, as broadly described, can be used to control gene expression through triple helix formation or antisense DNA or RNA, both of which methods are based on the binding of a polynucleotide sequence to DNA or RNA. Polynucleotides suitable for use in these methods are preferably 20 to 40 bases in length and are designed to be complementary to a region of the gene involved in transcription (triple helix—see Lee et al., Nucl. Acids Res. 6:3073 (1979); Cooney et al., Science 15241:456 (1988); and Dervan et al., Science 251:1360 (1991)) or to the mRNA itself (antisense—Olmno, J. Neurochem. 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988)). Triple helix-formation optimally results in a shut-off of RNA transcription from DNA, while antisense RNA hybridization blocks translation of an mRNA molecule into polypeptide. Both techniques have been demonstrated to be effective in model systems. Information contained in the sequences of the present invention is necessary for the design of an antisense or triple helix oligonucleotide. 
     3.16 Diagnostic Assays and Kits 
     The present invention further provides methods to identify the presence or expression of one of the ORFs of the present invention, or homolog thereof, in a test sample, using a nucleic acid probe or antibodies of the present invention, optionally conjugated or otherwise associated with a suitable label. 
     In general, methods for detecting a polynucleodide of the invention can comprise contacting a sample with a compound that binds to and forms a complex with the polynucleotide for a period sufficient to form the complex, and detecting the complex, so that if a complex is detected, a polynucleotide of the invention is detected in the sample. Such methods can also comprise contacting a sample under stringent hybridization conditions with nucleic acid primers that anneal to a polynucleotide of the invention under such conditions, and amplifying annealed polynucleotides, so that if a polynucleotide is amplified, a polynucleotide of the invention is detected in the sample. 
     In general, methods for detecting a polypeptide of the invention can comprise contacting a sample with a compound that binds to and forms a complex with the polypeptide for a period sufficient to form the complex, and detecting the complex, so that if a complex is detected, a polypeptide of the invention is detected in the sample. 
     In detail, such methods comprise incubating a test sample with one or more of the antibodies or one or more of the nucleic acid probes of the present invention and assaying for binding of the nucleic acid probes or antibodies to components within the test sample. 
     Conditions for incubating a nucleic acid probe or antibody with a test sample vary. Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid probe or antibody used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification or immunological assay formats can readily be adapted to employ the nucleic acid probes or antibodies of the present invention. Examples of such assays can be found in Chard, T., An Introduction to Radioimmunoassay and Related Techniques, Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G. R. et al., Techniques in Immunocytochemistry, Academic Press, Orlando, Fla. Vol. 1 (1982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology, Elsevier Science Publishers, Amsterdam, The Netherlands (1985). The test samples of the present invention include cells, protein or membrane extracts of cells, or biological fluids such as sputum, blood, serum, plasma, or urine. The test sample used in the above-described method will vary based on the assay format, nature of the detection method and the tissues, cells or extracts used as the sample to be assayed. Methods for preparing protein extracts or membrane extracts of cells are well known in the art and can be readily be adapted in order to obtain a sample which is compatible with the system utilized. 
     In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention. Specifically, the invention provides a compartment kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the probes or antibodies of the present invention; and (b) one or more other containers comprising one or more of the following: wash reagents, reagents capable of detecting presence of a bound probe or antibody. 
     In detail, a compartment kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers or strips of plastic or paper. Such containers allows one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross-contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers will include a container which will accept the test sample, a container which contains the antibodies used in the assay, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound antibody or probe. Types of detection reagents include labeled nucleic acid probes, labeled secondary antibodies, or in the alternative, if the primary antibody is labeled, the enzymatic, or antibody binding reagents which are capable of reacting with the labeled antibody. One skilled in the art will readily recognize that the disclosed probes and antibodies of the present invention can be readily incorporated into one of the established kit formats which are well known in the art. 
     3.17 Medical Imaging 
     The novel polypeptides and binding partners of the invention are useful in medical imaging of sites expressing the molecules of the invention (e.g., where the polypeptide of the invention is involved in the immune response, for imaging sites of inflammation or infection). See, e.g., Kunkel et al., U.S. Pat. No. 5,413,778. Such methods involve chemical attachment of a labeling or imaging agent, administration of the labeled polypeptide to a subject in a pharmaceutically acceptable carrier, and imaging the labeled polypeptide in vivo at the target site. 
     3.18 Screening Assays 
     Using the isolated proteins and polynucleotides of the invention, the present invention further provides methods of obtaining and identifying agents which bind to a polypeptide encoded by an ORF corresponding to any of the nucleotide sequences set forth in SEQ ID NOs: 1-948, or bind to a specific domain of the polypeptide encoded by the nucleic acid. In detail, said method comprises the steps of: 
     (a) contacting an agent with an isolated protein encoded by an ORF of the present invention, or nucleic acid of the invention; and 
     (b) determining whether the agent binds to said protein or said nucleic acid. 
     In general, therefore, such methods for identifying compounds that bind to a polynucleotide of the invention can comprise contacting a compound with a polynucleotide of the invention for a time sufficient to form a polynucleotide/compound complex, and detecting the complex, so that if a polynucleotide/compound complex is detected, a compound that binds to a polynucleotide of the invention is identified. 
     Likewise, in general, therefore, such methods for identifying compounds that bind to a polypeptide of the invention can comprise contacting a compound with a polypeptide of the invention for a time sufficient to form a polypeptide/compound complex, and detecting the complex, so that if a polypeptide/compound complex is detected, a compound that binds to a polynucleotide of the invention is identified. 
     Methods for identifying compounds that bind to a polypeptide of the invention can also comprise contacting a compound with a polypeptide of the invention in a cell for a time sufficient to form a polypeptide/compound complex, wherein the complex drives expression of a receptor gene sequence in the cell, and detecting the complex by detecting reporter gene sequence expression, so that if a polypeptide/compound complex is detected, a compound that binds a polypeptide of the invention is identified. 
     Compounds identified via such methods can include compounds which modulate the activity of a polypeptide of the invention (that is, increase or decrease its activity, relative to activity observed in the absence of the compound). Alternatively, compounds identified via such methods can include compounds which modulate the expression of a polynucleotide of the invention (that is, increase or decrease expression relative to expression levels observed in the absence of the compound). Compounds, such as compounds identified via the methods of the invention, can be tested using standard assays well known to those of skill in the art for their ability to modulate activity/expression. 
     The agents screened in the above assay can be, but are not limited to, peptides, carbohydrates, vitamin derivatives, or other pharmaceutical agents. The agents can be selected and screened at random or rationally selected or designed using protein modeling techniques. 
     For random screening, agents such as peptides, carbohydrates, pharmaceutical agents and the like are selected at random and are assayed for their ability to bind to the protein encoded by the ORF of the present invention. Alternatively, agents may be rationally selected or designed. As used herein, an agent is said to be “rationally selected or designed” when the agent is chosen based on the configuration of the particular protein. For example, one skilled in the art can readily adapt currently available procedures to generate peptides, pharmaceutical agents and the like, capable of binding to a specific peptide sequence, in order to generate rationally designed antipeptide peptides, for example see Hurby et al., Application of Synthetic Peptides: Antisense Peptides,” In Synthetic Peptides, A User&#39;s Guide, W. H. Freeman, NY (1992), pp. 289-307, and Kaspczak et al., Biochemistry 28:9230-8 (1989), or pharmaceutical agents, or the like. 
     In addition to the foregoing, one class of agents of the present invention, as broadly described, can be used to control gene expression through binding to one of the ORFs or EMFs of the present invention. As described above, such agents can be randomly screened or rationally designed/selected. Targeting the ORF or EMF allows a skilled artisan to design sequence specific or element specific agents, modulating the expression of either a single ORF or multiple ORFs which rely on the same EMF for expression control. One class of DNA binding agents are agents which contain base residues which hybridize or form a triple helix formation by binding to DNA or RNA. Such agents can be based on the classic phosphodiester, ribonucleic acid backbone, or can be a variety of sulfliydryl or polymeric derivatives which have base attachment capacity. 
     Agents suitable for use in these methods preferably contain 20 to 40 bases and are designed to be complementary to a region of the gene involved in transcription (triple helix—see Lee et al., Nucl. Acids Res. 6:3073 (1979); Cooney et al., Science 241:456 (1988); and Dervan et al., Science 251:1360 (1991)) or to the mRNA itself (antisense—Okano, J. Neurochem. 56:560 (1991); Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression, CRC Press, Boca Raton, Fla. (1988)). Triple helix-formation optimally results in a shut-off of RNA transcription from DNA, while antisense RNA hybridization blocks translation of an mRNA molecule into polypeptide. Both techniques have been demonstrated to be effective in model systems. Information contained in the sequences of the present invention is necessary for the design of an antisense or triple helix oligonucleotide and other DNA binding agents. 
     Agents which bind to a protein encoded by one of the ORFs of the present invention can be used as a diagnostic agent. Agents which bind to a protein encoded by one of the ORFs of the present invention can be formulated using known techniques to generate a pharmaceutical composition. 
     3.19 Use of Nucleic Acids as Probes 
     Another aspect of the subject invention is to provide for polypeptide-specific nucleic acid hybridization probes capable of hybridizing with naturally occurring nucleotide sequences. The hybridization probes of the subject invention may be derived from any of the nucleotide sequences SEQ ID NOs: 1-948. Because the corresponding gene is only expressed in a limited number of tissues, a hybridization probe derived from of any of the nucleotide sequences SEQ ID NOs: 1-948 can be used as an indicator of the presence of RNA of cell type of such a tissue in a sample. 
     Any suitable hybridization technique can be employed, such as, for example, in situ hybridization. PCR as described in U.S. Pat. Nos. 4,683,195 and 4,965,188 provides additional uses for oligonucleotides based upon the nucleotide sequences. Such probes used in PCR may be of recombinant origin, may be chemically synthesized, or a mixture of both. The probe will comprise a discrete nucleotide sequence for the detection of identical sequences or a degenerate pool of possible sequences for identification of closely related genomic sequences. 
     Other means for producing specific hybridization probes for nucleic acids include the cloning of nucleic acid sequences into vectors for the production of mRNA probes. Such vectors are known in the art and are commercially available and may be used to synthesize RNA probes in vitro by means of the addition of the appropriate RNA polymerase as T7 or SP6 RNA polymerase and the appropriate radioactively labeled nucleotides. The nucleotide sequences may be used to construct hybridization probes for mapping their respective genomic sequences. The nucleotide sequence provided herein may be mapped to a chromosome or specific regions of a chromosome using well known genetic and/or chromosomal mapping techniques. These techniques include in situ hybridization, linkage analysis against known chromosomal markers, hybridization screening with libraries or flow-sorted chromosomal preparations specific to known chromosomes, and the like. The technique of fluorescent in situ hybridization of chromosome spreads has been described, among other places, in Verma et al (1988) Human Chromosomes: A Manual of Basic Techniques, Pergamon Press, New York N.Y. 
     Fluorescent in situ hybridization of chromosomal preparations and other physical chromosome mapping techniques may be correlated with additional genetic map data. Examples of genetic map data can be found in the 1994 Genome Issue of Science (265:1981f). Correlation between the location of a nucleic acid on a physical chromosomal map and a specific disease (or predisposition to a specific disease) may help delimit the region of DNA associated with that genetic disease. The nucleotide sequences of the subject invention may be used to detect differences in gene sequences between normal, carrier or affected individuals. 
     3.20 Preparation of Support Bound Oligonucleotides 
     Oligonucleotides, i.e., small nucleic acid segments, may be readily prepared by, for example, directly synthesizing the oligonucleotide by chemical means, as is commonly practiced using an automated oligonucleotide synthesizer. 
     Support bound oligonucleotides may be prepared by any of the methods known to those of skill in the art using any suitable support such as glass, polystyrene or Teflon. One strategy is to precisely spot oligonucleotides synthesized by standard synthesizers. Inmobilization can be achieved using passive adsorption (Inouye &amp; Hondo, (1990) J. Clin. Microbiol. 28(6) 1469-72); using UV light (Nagata et al., 1985; Dahlen et al., 1987; Morrissey &amp; Collins, (1989) Mol. Cell Probes 3(2) 189-207) or by covalent binding of base modified DNA (Keller et al., 1988; 1989); all references being specifically incorporated herein. 
     Another strategy that may be employed is the use of the strong biotin-streptavidin interaction as a linker. For example, Broude et a. (1994) Proc. Natl. Acad. Sci. USA 91(8) 3072-6, describe the use of biotinylated probes, although these are duplex probes, that are immobilized on streptavidin-coated magnetic beads. Streptavidin-coated beads may be purchased from Dynal, Oslo. Of course, this same linking chemistry is applicable to coating any surface with streptavidin. Biotinylated probes may be purchased from various sources, such as, e.g., Operon Technologies (Alameda, Calif.). 
     Nunc Laboratories (Naperville, Ill.) is also selling suitable material that could be used. Nunc Laboratories have developed a method by which DNA can be covalently bound to the microwell surface termed Covalink NH. CovaLink NH is a polystyrene surface grafted with secondary amino groups (&gt;NH) that serve as bridge-heads for further covalent coupling. CovaLink Modules may be purchased from Nunc Laboratories. DNA molecules may be bound to CovaLink exclusively at the 5′-end by a phosphoramidate bond, allowing immobilization of more than 1 pmol of DNA (Rasmussen et al., (1991) Anal. Biochem. 198(1) 138-42). 
     The use of CovaLink NH strips for covalent binding of DNA molecules at the 5′-end has been described (Rasmussen et al., (1991). In this technology, a phosphoramidate bond is employed (Chu et al., (1983) Nucleic Acids Res. 11(8) 6513-29). This is beneficial as immobilization using only a single covalent bond is preferred. The phosphoramnidate bond joins the DNA to the CovaLink NH secondary amino groups that are positioned at the end of spacer arms covalently grafted onto the polystyrene surface through a 2 nm long spacer arm. To link an oligonucleotide to CovaLink NH via an phosphoramidate bond, the oligonucleotide terminus must have a 5′-end phosphate group. It is, perhaps, even possible for biotin to be covalently bound to CovaLink and then streptavidin used to bind the probes. 
     More specifically, the linkage method includes dissolving DNA in water (7.5 ng/ul) and denaturing for 10 min. at 95° C. and cooling on ice for 10 min. Ice-cold 0.1 M 1-methylimidazole, pH 7.0 (1-MeIm 7 ), is then added to a final concentration of 10 mM 1-MeIm 7 . A ss DNA solution is then dispensed into CovaLink NH strips (75 ul/well) standing on ice. 
     Carbodiimide 0.2 M 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), dissolved in 10 mM 1-MeIm 7 , is made fresh and 25 ul added per well. The strips are incubated for 5 hours at 50° C. After incubation the strips are washed using, e.g., Nunc-Immuno Wash; first the wells are washed 3 times, then they are soaked with washing solution for 5 min., and finally they are washed 3 times (where in the washing solution is 0.4 N NaOH, 0.25% SDS heated to 50° C.). 
     It is contemplated that a further suitable method for use with the present invention is that described in PCT Patent Application WO 90/03382 (Southern &amp; Maskos), incorporated herein by reference. This method of preparing an oligonucleotide bound to a support involves attaching a nucleoside 3′-reagent through the phosphate group by a covalent phosphodiester link to aliphatic hydroxyl groups carried by the support. The oligonucleotide is then synthesized on the supported nucleoside and protecting groups removed from the synthetic oligonucleotide chain under standard conditions that do not cleave the oligonucleotide from the support. Suitable reagents include nucleoside phosphoramidite and nucleoside hydrogen phosphorate. 
     An on-chip strategy for the preparation of DNA probe for the preparation of DNA probe arrays may be employed. For example, addressable laser-activated photodeprotection may be employed in the chemical synthesis of oligonucleotides directly on a glass surface, as described by Fodor et al. (1991) Science 251(4995) 767-73, incorporated herein by reference. Probes may also be immobilized on nylon supports as described by Van Ness et al. (1991) Nucleic Acids Res. 19(12) 3345-50; or linked to Teflon using the method of Duncan &amp; Cavalier (1 988) Anal. Biochem. 169(1) 104-8; all references being specifically incorporated herein. 
     To link an oligonucleotide to a nylon support, as described by Van Ness et al. (1991), requires activation of the nylon surface via alkylation and selective activation of the 5′-amine of oligonucleotides with cyanuric chloride. 
     One particular way to prepare support bound oligonucleotides is to utilize the light-generated synthesis described by Pease et al., (1994) PNAS USA 91(11) 5022-6, incorporated herein by reference). These authors used current photolithographic techniques to generate arrays of immobilized oligonucleotide probes (DNA chips). These methods, in which light is used to direct the synthesis of oligonucleotide probes in high-density, miniaturized arrays, utilize photolabile 5′-protected N-acyl-deoxynucleoside phosphoramidites, surface linker chemistry and versatile combinatorial synthesis strategies. A matrix of 256 spatially defined oligonucleotide probes may be generated in this manner. 
     3.21 Preparation of Nucleic Acid Fragments 
     The nucleic acids may be obtained from any appropriate source, such as cDNAs, genomic DNA, chromosomal DNA, iicrodissected chromosome bands, cosmid or YAC inserts, and RNA, including mRNA without any amplification steps. For example, Sambrook et al. (1989) describes three protocols for the isolation of high molecular weight DNA from mammalian cells (p. 9.14-9.23). 
     DNA fragments may be prepared as clones in M13, plasmid or lambda vectors and/or prepared directly from genomic DNA or cDNA by PCR or other amplification methods. Samples may be prepared or dispensed in multiwell plates. About 100-1000 ng of DNA samples may be prepared in 2-500 ml of final volume. 
     The nucleic acids would then be fragmented by any of the methods known to those of slill in the art including, for example, using restriction enzymes as described at 9.24-9.28 of Sambrook et al. (1989), shearing by ultrasound and NaOH treatment. 
     Low pressure shearing is also appropriate, as described by Schriefer et al. (1990) Nucleic Acids Res. 18(24) 7455-6, incorporated herein by reference). In this method, DNA samples are passed through a small French pressure cell at a variety of low to intermediate pressures. A lever device allows controlled application of low to intermediate pressures to the cell. The results of these studies indicate that low-pressure shearing is a useful alternative to sonic and enzymatic DNA iragmentation methods. 
     One particularly suitable way for fragmenting DNA is contemplated to be that using the two base recognition endonuclease, CviJI, described by Fitzgerald et al. (1992) Nucleic Acids Res. 20(14) 3753-62. These authors described an approach for the rapid fragmentation and fractionation of DNA into particular sizes that they contemplated to be suitable for shotgun cloning and sequencing. 
     The restriction endonuclease CviJI normally cleaves the recognition sequence PuGCPy between the G and C to leave blunt ends. Atypical reaction conditions, which alter the specificity of this enzyme (CviJI**), yield a quasi-random distribution of DNA fragments form the small molecule pUC19 (2688 base pairs). Fitzgerald et al. (1992) quantitatively evaluated the randomness of this fragmentation strategy, using a CviJI** digest of pUC19 that was size fractionated by a rapid gel filtration method and directly ligated, without end repair, to a lac Z minus M13 cloning vector. Sequence analysis of 76 clones showed that CviJI** restricts pyGCPy and PuGCPu, in addition to PuGCPy sites, and that new sequence data is accumulated at a rate consistent with random fragmentation. 
     As reported in the literature, advantages of this approach compared to sonication and agarose gel fractionation include: smaller amounts of DNA are required (0.2-0.5 ug instead of 2-5 ug); and fewer steps are involved (no preligation, end repair, chemical extraction, or agarose gel electrophoresis and elution are needed 
     Irrespective of the manner in which the nucleic acid fragments are obtained or prepared, it is important to denature the DNA to give single stranded pieces available for hybridization. This is achieved by incubating the DNA solution for 2-5 minutes at 80-90° C. The solution is then cooled quickly to 2° C. to prevent renaturation of the DNA fragments before they are contacted with the chip. Phosphate groups must also be removed from genomic DNA by methods known in the art. 
     3.22 Preparation of DNA Arrays 
     Arrays may be prepared by spotting DNA samples on a support such as a nylon membrane. Spotting may be performed by using arrays of metal pins (the positions of which correspond to an array of wells in a microtiter plate) to repeated by transfer of about 20 nl of a DNA solution to a nylon membrane. By offset printing, a density of dots higher than the density of the wells is achieved. One to 25 dots may be accommodated in 1 mm 2 , depending on the type of label used. By avoiding spotting in some preselected number of rows and columns, separate subsets (subarrays) may be formed. Samples in one subarray may be the same genomic segment of DNA (or the same gene) from different individuals, or may be different, overlapped genomic clones. Each of the subarrays may represent replica spotting of the same samples. In one example, a selected gene segment may be amplified from 64 patients. For each patient, the amplified gene segment may be in one 96-well plate (all 96 wells containing the same sample). A plate for each of the 64 patients is prepared. By using a 96-pin device, all samples may be spotted on one 8×12 cm membrane. Subarrays may contain 64 samples, one from each patient. Where the 96 subarrays are identical, the dot span may be 1 mm 2  and there may be a 1 mm space between subarrays. 
     Another approach is to use membranes or plates (available from NUNC, Naperville, Ill.) which may be partitioned by physical spacers e.g. a plastic grid molded over the membrane, the grid being similar to the sort of membrane applied to the bottom of multiwell plates, or hydrophobic strips. A fixed physical spacer is not preferred for imaging by exposure to flat phosphor-storage screens or x-ray films. 
     The present invention is illustrated in the following examples. Upon consideration of the present disclosure, one of skill in the art will appreciate that many other embodiments and variations may be made in the scope of the present invention. Accordingly, it is intended that the broader aspects of the present invention not be limited to the disclosure of the following examples. The present invention is not to be limited in scope by the exemplified embodiments which are intended as illustrations of single aspects of the invention, and compositions and methods which are functionally equivalent are within the scope of the invention. Indeed, numerous modifications and variations in the practice of the invention are expected to occur to those skilled in the art upon consideration of the present preferred embodiments. Consequently, the only limitations which should be placed upon the scope of the invention are those which appear in the appended claims. 
     All references cited within the body of the instant specification are hereby incorporated by reference in their entirety. 
     4.0 EXAMPLES 
     4.1 Example 1 
     Novel Nucleic Acid Sequences Obtained from Various Libraries 
     A plurality of novel nucleic acids were obtained from cDNA libraries prepared from various human tissues and in some cases isolated from a genomic library derived from human chromosome using standard PCR, SBH sequence signature analysis and Sanger sequencing techniques. The inserts of the library were amplified with PCR using primers specific for the vector sequences which flank the inserts. Clones from cDNA libraries were spotted on nylon membrane filters and screened with oligonucleotide probes (e.g., 7-mers) to obtain signature sequences. The clones were clustered into groups of similar or identical sequences. Representative clones were selected for sequencing. 
     In some cases, the 5′ sequence of the amplified inserts was then deduced using a typical Sanger sequencing protocol. PCR products were purified and subjected to fluorescent dye terminator cycle sequencing. Single pass gel sequencing was done using a 377 Applied Biosystems (ABI) sequencer to obtain the novel nucleic acid sequences. In some cases RACE (Random Amplification of cDNA Ends) was performed to further extend the sequence in the 5′ direction. 
     4.2 Example 2 
     Novel Nucleic Acids 
     The novel nucleic acids of the present invention of the invention were assembled from sequences that were obtained from a cDNA library by methods described in Example 1 above, and in some cases sequences obtained from one or more public databases, The nucleic acids were assembled using an EST sequence as a seed. Then a recursive algorithm was used to extend the seed EST into an extended assemblage, by pulling additional sequences from different databases (i.e., Hyseq&#39;s database containing EST sequences, dbEST version 119, gb pri 119, and UniGene version 119) that belong to this assemblage. The algorithm terminated when there was no additional sequences from the above databases that would extend the assemblage. Inclusion of component sequences into the assemblage was based on a BLASTN hit to the extending assemblage with BLAST score greater than 300 and percent identity greater than 95%. 
     Using PHRAP (Univ. of Washington) or CAP4 (Paracel), a full length gene cDNA sequence and its corresponding protein sequence were generated from the assemblage. Any frame shifts and incorrect stop codons were conrected by hand editing. During editing, the sequence was checked using FASTY and/or BLAST against Genbank (i.e., dbEST version 121, gb pri 121, UniGene version 121, Genpept release 121). Other computer programs which may have been used in the editing process were phredPhrap and Consed (University of Washington) and ed-ready, ed-ext and cg-zip-2 (Hyseq, Inc.). The full-length nucleotide and amino acid sequences, including splice variants resulting from these procedures are shown in the Sequence Listing as SEQ ID NO: 1-948. 
     Table 1 shows the various tissue sources of SEQ ID NO: 1-948. 
     The homology for SEQ ID NO: 1-948 were obtained by a BLASTP version 2.0al 19MP-WashU search against Genpept release 120 and the amino acid version of Geneseq released on Oct. 26, 2000, using BLAST algorithm. The results showed homologues for SEQ ID NO: 1-948 from Genpept. The homologues with identifiable functions for SEQ ID NO: 1-948 are shown in Table 2 below. 
     Using eMatrix software package (Stanford University, Stanford, Calif.) (Wu et al., J. Comp. Biol., Vol. 6 pp. 219-235 (1999) herein incorporated by reference), all the sequences were examined to determine whether they had identifiable signature regions. Table 3 shows the signature region found in the indicated polypeptide sequences, the description of the signature, the eMatrix p-value(s) and the position(s) of the signature within the polypeptide sequence. 
     Using the pFam software program (Sonnhammer et al., Nucleic Acids Res., Vol. 26(1) pp. 320-322 (1998) herein incorporated by reference) all the polypeptide sequences were examined for domains with homology to certain peptide domains. Table 4 shows the name of the domain found, the description, the p-value and the pFam score for the identified domain within the sequence. 
     The nucleotide sequence within the sequences that codes for signal peptide sequences and their cleavage sites can be determined from using Neural Network SignalP V1.1 program (from Center for Biological Sequence Analysis, The Technical University of Denmark). The process for identifying prokaryotic and eukaryotic signal peptides and their cleavage sites are also disclosed by Henrik Nielson, Jacob Engelbrecht, Soren Brunak, and Gunnar von Heijne in the publication “Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites” Protein Engineering, Vol. 10, no. 1, pp. 1-6 (1997), incorporated herein by reference. A maximum S score and a mean S score, as described in the Nielson et as reference, was obtained for the polypeptide sequences. Table 5 shows the position of the signal peptide in each of the polypeptides and the maximum score and mean score associated with that signal peptide. 
     
       
         
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                 HYSEQ 
                   
               
               
                 TISSUE 
                 LIBRARY/ 
                 LIBRARY 
                   
               
               
                 ORIGIN 
                 RNA SOURCE 
                 NAME 
                 SEQ ID NOS: 
               
               
                   
               
             
             
               
                 adult brain 
                 GIBCO 
                 AB3001 
                 16-17 19 40 66 92-94 97 124 131 134 163 
               
               
                   
                   
                   
                 186 188 208 213 231 268-270 284 288 295 
               
               
                   
                   
                   
                 297 299 311 315-325 340 373 387 396 407 
               
               
                   
                   
                   
                 429 469 489 495 498-499 533 542 545 562 
               
               
                   
                   
                   
                 568 587 589 618-619 643 664 687-688 694- 
               
               
                   
                   
                   
                 695 730 748 836 876 882 884 902 925-926 
               
               
                   
                   
                   
                 948 
               
               
                 adult brain 
                 GIBCO 
                 ABD003 
                 2 22-24 29 33 43 45 50-51 66 71 75 77 82 
               
               
                   
                   
                   
                 87-88 91-92 95 131 140 157 179 188-192 200 
               
               
                   
                   
                   
                 208 213 220 225 247 252 257 261 263-265 
               
               
                   
                   
                   
                 277 284 288 295 299 301 315-325 355-356 
               
               
                   
                   
                   
                 373 387-389 392 395-396 407 423 431 443- 
               
               
                   
                   
                   
                 444 450-451 457 459 468 476 489 495 499- 
               
               
                   
                   
                   
                 500 514 520-522 532-533 541-542 545-546 
               
               
                   
                   
                   
                 557-558 562 564 576-577 581-583 588-589 
               
               
                   
                   
                   
                 591 595 597 599 601 610 619 631-632 639 
               
               
                   
                   
                   
                 643-644 654-655 658-660 664 667 676 682 
               
               
                   
                   
                   
                 687-688 693 696 700 704 711 713-714 746 
               
               
                   
                   
                   
                 758 765-766 774-775 780 800 802 804 807 
               
               
                   
                   
                   
                 810 827 829 834 842 850 854-855 866 870- 
               
               
                   
                   
                   
                 871 878 892-893 897 899 910 916 920-921 
               
               
                   
                   
                   
                 929 931-932 934 
               
               
                 adult brain 
                 Clontech 
                 ABR001 
                 12 51 87 142 169 178 180 245 263 286 288 
               
               
                   
                   
                   
                 290 295 304 308 311-313 375 379-380 403 
               
               
                   
                   
                   
                 425 428 431 458 486 499 503 512 557-558 
               
               
                   
                   
                   
                 567-568 606 610 641 651 695 704 730 741 
               
               
                   
                   
                   
                 754 766 810 822 827 841 850 864 871 884 
               
               
                   
                   
                   
                 897 917 920 925-927 934 946 
               
               
                 adult brain 
                 Clontech 
                 ABR006 
                 2 14-15 22-23 29 32-33 49 66-68 83 99 111- 
               
               
                   
                   
                   
                 112 115 129 131 142 147 153 157 163 169 
               
               
                   
                   
                   
                 189-192 200 205 207 212-214 218 221 229 
               
               
                   
                   
                   
                 234 256-257 263 272 276 279 282 292-299 
               
               
                   
                   
                   
                 301 311 315 340-343 349 376-377 383-386 
               
               
                   
                   
                   
                 388 403 405 407 410 425 438 453-454 460 
               
               
                   
                   
                   
                 463 469 474 489 495 499-500 511 522 531- 
               
               
                   
                   
                   
                 532 539 541 545-546 551 556 563 565 571 
               
               
                   
                   
                   
                 579-583 591 594 606 626 628 631-632 643 
               
               
                   
                   
                   
                 647 651 678 684 691-692 700 717 721 726 
               
               
                   
                   
                   
                 730 732 741 744 754 757 769 772 774 782 
               
               
                   
                   
                   
                 788 793 810 820 827-828 853 867 869 875 
               
               
                   
                   
                   
                 879 897 913 921-922 925-926 933-934 939- 
               
               
                   
                   
                   
                 941 947 
               
               
                 adult brain 
                 Clontech 
                 ABR008 
                 1-2 9-10 13 16-18 23 27-28 30-32 37 39 42- 
               
               
                   
                   
                   
                 43 46 49-51 66 70 76 80 83 86-87 95-97 109 
               
               
                   
                   
                   
                 111-112 116-117 124 130-131 133-134 136- 
               
               
                   
                   
                   
                 137 141-142 146-147 152-157 160 162 169 
               
               
                   
                   
                   
                 171 179 184 189-192 195 200-201 206 211- 
               
               
                   
                   
                   
                 212 216-218 239 247-248 250 252 254-258 
               
               
                   
                   
                   
                 261-263 271-272 276 278 282 288 293-295 
               
               
                   
                   
                   
                 297 300 302 307 309 311 314-326 328 333 
               
               
                   
                   
                   
                 337-341 343 347 349 351-354 358 360-361 
               
               
                   
                   
                   
                 367 374 376-378 381 384 388-390 393 395- 
               
               
                   
                   
                   
                 396 400-403 405 407 409 411 414 418-420 
               
               
                   
                   
                   
                 422 427-429 433 438 440-441 445-447 450 
               
               
                   
                   
                   
                 453-455 458 460-461 463 466-470 474 476 
               
               
                   
                   
                   
                 486 491-493 496 498-500 507 511 514 520- 
               
               
                   
                   
                   
                 521 525 527-529 531-532 534-535 542 546 
               
               
                   
                   
                   
                 548-549 551-552 557-558 560 562 564-566 
               
               
                   
                   
                   
                 568 571-572 578-583 586-587 590-591 594 
               
               
                   
                   
                   
                 599 602 606 618-619 621 626 629 631-634 
               
               
                   
                   
                   
                 643-644 647 651 656-660 664 670 672 677 
               
               
                   
                   
                   
                 680 684 687-688 691-695 697 706 709-710 
               
               
                   
                   
                   
                 712-714 716-718 721-722 724-725 727-728 
               
               
                   
                   
                   
                 730 733 740-741 745 751-752 754 761 765 
               
               
                   
                   
                   
                 774 777-779 787 790 792-793 799 801-804 
               
               
                   
                   
                   
                 808 810 812 820 822 824 827 831-832 834 
               
               
                   
                   
                   
                 836 845 850 858-861 868-869 871-672 875- 
               
               
                   
                   
                   
                 876 883 887 891 897 900 904 907 910 913 
               
               
                   
                   
                   
                 917-920 925-927 929 931-934 938-941 946- 
               
               
                   
                   
                   
                 947 
               
               
                 adult brain 
                 Clontech 
                 ABR011 
                 51 133 810 892 
               
               
                 adult brain 
                 BioChain 
                 ABR012 
                 140 208 311 748 810 
               
               
                 adult brain 
                 Invitrogen 
                 ABR013 
                 51 245 311 316-325 436 717 810 936 
               
               
                 adult brain 
                 Invitrogen 
                 ABR014 
                 2 51 65 84 86 134 311 316-325 384 422 445 
               
               
                   
                   
                   
                 460 503 525 564 634 651 721 794 804 810 
               
               
                   
                   
                   
                 922 
               
               
                 adult brain 
                 Invitrogen 
                 ABR015 
                 37 134 263 272 277 294 311 443 467 500 514 
               
               
                   
                   
                   
                 582-583 619 651 694 850 871-872 883 888 
               
               
                   
                   
                   
                 936 
               
               
                 adult brain 
                 Invitrogen 
                 ABR016 
                 19 22 57 134 188 233 271 277 299 373 440 
               
               
                   
                   
                   
                 444 459 469 514 640 717 882 890 920 
               
               
                 adult brain 
                 Invitrogen 
                 ABT004 
                 1-2 18 28 51 55-57 67 87-88 115 119 137- 
               
               
                   
                   
                   
                 139 142 163 200 204 213 218 257 263 271 
               
               
                   
                   
                   
                 282 288 299 301 311 341 358 370 378 402 
               
               
                   
                   
                   
                 407 422-423 427 458 460 463 499 504 534- 
               
               
                   
                   
                   
                 535 551 557-558 571 586 605-606 610 618 
               
               
                   
                   
                   
                 627-628 640 643 680 687 691-692 697 701- 
               
               
                   
                   
                   
                 702 715 719-721 725 727 753-754 758 771 
               
               
                   
                   
                   
                 782 810 827 859 871-872 881 913 920 925- 
               
               
                   
                   
                   
                 926 938-941 944 946 
               
               
                 cultured 
                 Stratagene 
                 ADP001 
                 2 43 51 73 76 88 97 142 166 181 186 188 
               
               
                 preadipocytes 
                   
                   
                 208 257 262-263 267-270 282 311 316-325 
               
               
                   
                   
                   
                 383 386 427-429 459 463 465 493 507 514 
               
               
                   
                   
                   
                 522 545 552 572 643 651 667 700 721 740 
               
               
                   
                   
                   
                 754 758 778 795 872 881 883 888 947 
               
               
                 adrenal gland 
                 Clontech 
                 ADR002 
                 3-6 10-11 13 16 20-21 24 27-28 33 38 48-49 
               
               
                   
                   
                   
                 51 53-54 58 66-67 75 88 97 99 124-125 130 
               
               
                   
                   
                   
                 140 157-158 179 188 197-198 200 212-214 
               
               
                   
                   
                   
                 216 218 224 229 231 237 257 267 279 281- 
               
               
                   
                   
                   
                 282 288 302 311 326 362 376-377 381 383 
               
               
                   
                   
                   
                 396 398-403 429 443 453-454 456 459-460 
               
               
                   
                   
                   
                 474 489 515 526 531-532 540 545 550 559 
               
               
                   
                   
                   
                 564 568 577 581 586 589 599 605 610 613 
               
               
                   
                   
                   
                 631-632 643 648 651 667 670 672 681 684 
               
               
                   
                   
                   
                 699 703 706 708 717-718 734 736 751 779 
               
               
                   
                   
                   
                 785-786 795 813 817 837 871 876 887-888 
               
               
                   
                   
                   
                 897 904 907 916 921 924-926 948 
               
               
                 adult heart 
                 GIBCO 
                 AHR001 
                 1-2 5-6 14-18 20-21 23 28 32 37 41 45 51 
               
               
                   
                   
                   
                 53 55-56 62 66 69-70 80-81 85 87 91 97 107 
               
               
                   
                   
                   
                 120-121 124 134 140-141 156 163 165-166 
               
               
                   
                   
                   
                 172 188-192 195 197-198 200 208 213 216 
               
               
                   
                   
                   
                 221 229 231 235 261-265 267 271 276 284 
               
               
                   
                   
                   
                 288 302 305 308 311 316-325 328 333-334 
               
               
                   
                   
                   
                 337-338 347 368-369 373 376-377 379-380 
               
               
                   
                   
                   
                 389 396 420 440 445 453-454 459-460 465 
               
               
                   
                   
                   
                 468 478 483-484 489 491-493 495 501 504 
               
               
                   
                   
                   
                 507 514 524 529 533 539 541-543 545 549 
               
               
                   
                   
                   
                 552-553 564 566 568 574 577 581-583 587 
               
               
                   
                   
                   
                 589-591 596 599 602 605 608-609 618-619 
               
               
                   
                   
                   
                 623 625 629-632 643 645 647 651 664 672 
               
               
                   
                   
                   
                 676 678 683-684 707 714 716-717 732 735 
               
               
                   
                   
                   
                 740 743-744 751 754 757 765 775 778 784- 
               
               
                   
                   
                   
                 786 788 807-808 810 826 828-829 842 850 
               
               
                   
                   
                   
                 860 876 878-880 890 894 897 899 902 916 
               
               
                   
                   
                   
                 923-927 933 939-941 
               
               
                 adult kidney 
                 GIBCO 
                 AKD001 
                 1-2 5-6 13 16-17 19-23 26 28 33 38-39 43 
               
               
                   
                   
                   
                 45 48-51 55-57 60 66-67 69-73 79 82-83 87 
               
               
                   
                   
                   
                 90 94 96-97 100 103 126 131 134 140 148- 
               
               
                   
                   
                   
                 149 157 163 166 179 184 186 188-192 200- 
               
               
                   
                   
                   
                 203 213-216 220-221 224 226-229 232 235 
               
               
                   
                   
                   
                 245 252 257 261-263 268-270 272-274 276- 
               
               
                   
                   
                   
                 277 279 282 288 290 294 299 308 311 316- 
               
               
                   
                   
                   
                 325 332 335 339-340 358 360-363 373 375 
               
               
                   
                   
                   
                 379-380 386 388-389 392 395-396 402 413 
               
               
                   
                   
                   
                 421 423-424 428-429 431 436 440 444 450 
               
               
                   
                   
                   
                 454 457 459-460 468-469 476 489 492-493 
               
               
                   
                   
                   
                 499 504 511 513-514 520-521 524-526 531 
               
               
                   
                   
                   
                 533 538-542 544-547 552 564 567-568 574 
               
               
                   
                   
                   
                 577-578 582-583 590-591 595-596 598 602 
               
               
                   
                   
                   
                 607 610 613 618-619 622 631-632 639-642 
               
               
                   
                   
                   
                 644 647 651 654-655 658-659 664 667-669 
               
               
                   
                   
                   
                 673 678 680-682 684 687 689 693 696 706- 
               
               
                   
                   
                   
                 707 712 714-715 717-718 721 729-731 734- 
               
               
                   
                   
                   
                 736 740 744 748 754 760 771 774 782 784 
               
               
                   
                   
                   
                 789 795 807 809-810 819 825 834 836-837 
               
               
                   
                   
                   
                 842 850 859 870 872 876 878-879 884 887 
               
               
                   
                   
                   
                 890 895 897-899 902 905 910 919-921 925- 
               
               
                   
                   
                   
                 926 933 936 944 
               
               
                 adult kidney 
                 Invitrogen 
                 AKT002 
                 1 14-15 28 30 35-37 53-54 73 88 112 114 
               
               
                   
                   
                   
                 129 134 137 140 149 157 166 172 186-188 
               
               
                   
                   
                   
                 191-192 203-204 213 235 245 257 262-263 
               
               
                   
                   
                   
                 266 268-270 273-274 288-289 297 299 302 
               
               
                   
                   
                   
                 310-313 315-325 335 340 358 373 378-381 
               
               
                   
                   
                   
                 395 413 423 441 450 453 456 459-460 470 
               
               
                   
                   
                   
                 477 491-494 500 513 540 542 545 554 556 
               
               
                   
                   
                   
                 564 567 587 591 619 622 627 633 643 668- 
               
               
                   
                   
                   
                 669 677 684 689 693 701-702 704 714 729- 
               
               
                   
                   
                   
                 730 754 758 760 777 781 785-786 788-789 
               
               
                   
                   
                   
                 807 836-837 840 849-850 872 876 881 890 
               
               
                   
                   
                   
                 895 905-906 913 923 925-926 931-933 944 
               
               
                 adult lung 
                 GIBCO 
                 ALG001 
                 5-6 16 28 38 51 74 97 122 124 134 140 163 
               
               
                   
                   
                   
                 188-192 200 218 221 262-263 268-272 294 
               
               
                   
                   
                   
                 311 316-325 379-380 429 463 468 493 511 
               
               
                   
                   
                   
                 520-522 537-538 542 545 568-569 595 622 
               
               
                   
                   
                   
                 643-644 664 667 711 714 721 730 754 775 
               
               
                   
                   
                   
                 850 860 863 879 887 897 925-926 944 
               
               
                 lymph node 
                 Clontech 
                 ALN001 
                 43 98 131 140 163 188 221 245 277 299 311 
               
               
                   
                   
                   
                 491 515 546 564 593 603 610 615 630 682 
               
               
                   
                   
                   
                 694 707 717 800 831 850 878 880 936 939- 
               
               
                   
                   
                   
                 941 947 
               
               
                 young liver 
                 GIBCO 
                 ALV001 
                 3-4 17 20-21 32 43 55-56 70 100 134 137 
               
               
                   
                   
                   
                 163 172 174 179 186 188-192 200 213 216 
               
               
                   
                   
                   
                 219 221 229 232 252 275 301 311 315-325 
               
               
                   
                   
                   
                 378 381 392 441 459-460 497 499-500 514 
               
               
                   
                   
                   
                 524 526 533 539 550 568 571 588-589 595 
               
               
                   
                   
                   
                 619 622 631-632 642 658-659 664 677 680 
               
               
                   
                   
                   
                 693 700 707 713 719 743 754 757-758 766 
               
               
                   
                   
                   
                 807 834 863 867 876 884 887 904 907 
               
               
                 adult liver 
                 Invitrogen 
                 ALV002 
                 5-6 28 35-36 52 54 70 72 86-87 103 112 127 
               
               
                   
                   
                   
                 134 140 159 179 188 200-201 213 218-219 
               
               
                   
                   
                   
                 225 239-240 257 263 271 275 311 315 367 
               
               
                   
                   
                   
                 373 388 392 444 459-460 464 468 497-499 
               
               
                   
                   
                   
                 512 527 532 542 545 562 599 605 629 640 
               
               
                   
                   
                   
                 657 680 684 687-688 706 713 715 717-718 
               
               
                   
                   
                   
                 721 742 754 758 771 791-793 818 829 843 
               
               
                   
                   
                   
                 854-855 871 878-879 887 921 933-934 
               
               
                 adult liver 
                 Clontech 
                 ALV003 
                 159 179 189-192 201 219 257 349 392 568 
               
               
                   
                   
                   
                 664 753 796 887 934 
               
               
                 adult ovary 
                 Invitrogen 
                 AOV001 
                 2-7 10 13 18-22 25 27-28 30-31 33 38-39 
               
               
                   
                   
                   
                 41-43 45 48 50-51 53-56 62 66-67 69 72 74- 
               
               
                   
                   
                   
                 75 80 83 85-87 93 95 99-101 107 112-115 
               
               
                   
                   
                   
                 120 124-126 129 131 134-137 140 142-143 
               
               
                   
                   
                   
                 147-148 162-163 172 178 188 191-192 200 
               
               
                   
                   
                   
                 204 208 212-213 220-221 225 229 231 235 
               
               
                   
                   
                   
                 237 246-247 252-253 258 261-262 264-265 
               
               
                   
                   
                   
                 267-272 276-279 282 287-288 290 293-294 
               
               
                   
                   
                   
                 299 307-308 311 316-327 332 337-338 340- 
               
               
                   
                   
                   
                 342 349 360-362 373-374 379-381 386 388- 
               
               
                   
                   
                   
                 389 393 396 399 403 413-414 423 425 427 
               
               
                   
                   
                   
                 429 431 441 444-445 450 452 454-455 457 
               
               
                   
                   
                   
                 459-460 462 467-470 475 477 483-484 489 
               
               
                   
                   
                   
                 491-493 495-496 500 504-505 507 515 518- 
               
               
                   
                   
                   
                 519 522-523 527-529 531 533 537-540 542 
               
               
                   
                   
                   
                 545-546 548 551-552 555 564 568 570-571 
               
               
                   
                   
                   
                 577 579 581-583 589-596 599-600 605 610 
               
               
                   
                   
                   
                 613 615-616 619 623 625-627 630-636 639 
               
               
                   
                   
                   
                 641-644 647 649 651 654-655 664 668-669 
               
               
                   
                   
                   
                 672 676 678 680-682 684 687 694 701-704 
               
               
                   
                   
                   
                 706-707 715-717 721-722 727 729 731-732 
               
               
                   
                   
                   
                 734-735 738 740 743 748-749 753-754 758 
               
               
                   
                   
                   
                 764 771 775 777-782 784 800 802 807 821- 
               
               
                   
                   
                   
                 822 824 828 834 836-837 842 846-847 850 
               
               
                   
                   
                   
                 860-863 866 870-871 876-880 882 884 887 
               
               
                   
                   
                   
                 890-891 897 899 901 906 910 913 920-921 
               
               
                   
                   
                   
                 923-924 933 939-941 944 947 
               
               
                 adult placenta 
                 Clontech 
                 APL001 
                 34 68 102 263 444 493 520-521 534-535 689 
               
               
                   
                   
                   
                 706 754 797-798 
               
               
                 placenta 
                 Invitrogen 
                 APL002 
                 2 14-15 43 55-56 66-67 134 184 213 221 229 
               
               
                   
                   
                   
                 252 257 263 277 287 394 443 529 532 618 
               
               
                   
                   
                   
                 622 684 742 754 810 829 883 902 
               
               
                 adult spleen 
                 GIBCO 
                 ASP001 
                 2 14-15 20-22 29 38 43 48 51 53-56 65 67 
               
               
                   
                   
                   
                 72 74 84 87 131-132 134 137 140 172 188- 
               
               
                   
                   
                   
                 192 200 212 221 256 263 271 282 308 311 
               
               
                   
                   
                   
                 316-325 343 383 389 423 436 441 443 459- 
               
               
                   
                   
                   
                 460 467 469 495 499-500 505 514 520-522 
               
               
                   
                   
                   
                 524 529 537 539 545 552 585 619 631-632 
               
               
                   
                   
                   
                 639 643 664 673 707 723 735 742-744 758 
               
               
                   
                   
                   
                 771 799 810 817 836 850 878 925-926 934 
               
               
                   
                   
                   
                 936 
               
               
                 testis 
                 GIBCO 
                 ATS001 
                 1 3-4 14-16 28 31 45-46 66 85 90 95 97 103 
               
               
                   
                   
                   
                 112 128-130 134 140 163 166 188 191-192 
               
               
                   
                   
                   
                 199-200 213 226-228 261-265 267-271 284 
               
               
                   
                   
                   
                 302 311 316-325 327 379-380 391 413 421 
               
               
                   
                   
                   
                 428 444 454 457 459-460 467 491 493 495 
               
               
                   
                   
                   
                 500 505 519 525 529 532 534-535 545 552 
               
               
                   
                   
                   
                 556 566 568 575 596 599 613 616-617 647 
               
               
                   
                   
                   
                 649 651 680 684 703 707 716 719 721 727 
               
               
                   
                   
                   
                 734 738 740 744 748 758 765-766 774 777 
               
               
                   
                   
                   
                 782 802 810 817 827-828 834 842 846-847 
               
               
                   
                   
                   
                 850 862-863 871-872 878 880 892 901 916- 
               
               
                   
                   
                   
                 917 921 
               
               
                 adult bladder 
                 Invitrogen 
                 BLD001 
                 5-6 8 20-21 28 72 91 122 126 130 166 188 
               
               
                   
                   
                   
                 197 200 213-214 225 257 262 315-325 341 
               
               
                   
                   
                   
                 409 486 491 572 593 622 650 673 691-692 
               
               
                   
                   
                   
                 810 813 861 870 877 883 887 904 
               
               
                 bone marrow 
                 Clontech 
                 BMD001 
                 8 13-16 28 38 43 45-48 50-51 57 62-63 65 
               
               
                   
                   
                   
                 67 84-85 97 100 104 118 122-124 131 134 
               
               
                   
                   
                   
                 140 163 188 214 216 221 224 231 245 252 
               
               
                   
                   
                   
                 261-263 268-270 273-274 279 288 290 311 
               
               
                   
                   
                   
                 373 378 389-391 395 414 428 431 436 440- 
               
               
                   
                   
                   
                 441 443 451 455 459-460 465 469-470 475 
               
               
                   
                   
                   
                 495 497-498 502 507 514-519 529 537-538 
               
               
                   
                   
                   
                 542 546 550 552 556 560-561 563-564 568 
               
               
                   
                   
                   
                 576-577 580 587 589 596 601-602 610-613 
               
               
                   
                   
                   
                 619-620 626 642-643 647 651 664 666 668 
               
               
                   
                   
                   
                 676 678 681-682 684 696 704 706-707 715 
               
               
                   
                   
                   
                 727 730 732-735 740 748 753 758 761 764 
               
               
                   
                   
                   
                 771 775 780 794 800-801 830 834 836 842 
               
               
                   
                   
                   
                 850 863 871-872 878-879 882 884 888 897 
               
               
                   
                   
                   
                 900-901 904 910 921 923 929 934 947 
               
               
                 bone marrow 
                 Clontech 
                 BMD002 
                 1-2 5-6 10 13 16-21 27 31 38 42-43 46 57 
               
               
                   
                   
                   
                 65-66 76 80 84 87 97 99 110 112 118 131 
               
               
                   
                   
                   
                 134 137 140 145 161 163 165 172 195 206 
               
               
                   
                   
                   
                 208 221 229 231 237 244 247 252 256 267- 
               
               
                   
                   
                   
                 270 272 276 278-279 282 284 288 294 301 
               
               
                   
                   
                   
                 304 307 311 316-327 333-334 337-338 345- 
               
               
                   
                   
                   
                 347 352 360-361 368 373 376-378 381 383 
               
               
                   
                   
                   
                 388 414 436 441 443 450 452 454-455 457 
               
               
                   
                   
                   
                 469-470 483-484 486 490 498 516 519-521 
               
               
                   
                   
                   
                 524 530-531 539 542-543 545-546 551 553 
               
               
                   
                   
                   
                 555 559 564 571 576-577 580 585 591 594 
               
               
                   
                   
                   
                 602 604-605 607-608 610-612 619-621 625- 
               
               
                   
                   
                   
                 626 629 631-632 639-640 644 650-651 664- 
               
               
                   
                   
                   
                 665 684 687-688 693 699 703 714 723-724 
               
               
                   
                   
                   
                 727 733 735 740 742 745 748 750-752 754- 
               
               
                   
                   
                   
                 755 777-780 784 787 794-795 802 809 817 
               
               
                   
                   
                   
                 824 827 831-832 834 846-847 850-851 854- 
               
               
                   
                   
                   
                 855 861 867 875 878 883 886 891 894 897 
               
               
                   
                   
                   
                 900 902 910 914 919 921 925-926 929 936 
               
               
                   
                   
                   
                 939-941 944 
               
               
                 bone marrow 
                 Clontech 
                 BMD004 
                 65 
               
               
                 bone marrow 
                 Clontech 
                 BMD007 
                 65 76 84 245 516 
               
               
                 adult colon 
                 Invitrogen 
                 CLN001 
                 19-21 53 55-57 72 88 133-134 168 213 245 
               
               
                   
                   
                   
                 252 311-313 316-325 340 443 459 469 483- 
               
               
                   
                   
                   
                 484 486 497 515-516 597 606 622 643 667 
               
               
                   
                   
                   
                 676 706 718 742-743 753 766 829 833 872 
               
               
                   
                   
                   
                 887 902 923 929 
               
               
                 Mixture of 16 
                 Various 
                 CTL016 
                 52 137 189-192 316-325 529 591 
               
               
                 tissues- 
                 Vendors* 
               
               
                 mRNAs* 
               
               
                 Mixture of 16 
                 Various 
                 CTL021 
                 65 84 169 189-192 311 316-325 406 676 727 
               
               
                 tissues- 
                 Vendors* 
                   
                 782 850 
               
               
                 mRNAs* 
               
               
                 Mixture of 16 
                 Various 
                 CTL028 
                 65 
               
               
                 tissues-mRNAs* 
                 Vendors* 
               
               
                 adult cervix 
                 BioChain 
                 CVX001 
                 3-4 14-16 20-23 25 33 42-43 45 48-50 54 57 
               
               
                   
                   
                   
                 67 69 75 85 87 91 95-97 107 110 114 124 
               
               
                   
                   
                   
                 126-127 131 134 137 140 150 157 163 165 
               
               
                   
                   
                   
                 172 185-188 200 204 212-213 216 225 229 
               
               
                   
                   
                   
                 245 252 257 261-263 266-270 276 282 288 
               
               
                   
                   
                   
                 290 301-302 308 316-325 327 340 363-364 
               
               
                   
                   
                   
                 372-373 378 383 388-392 394 396 409 413- 
               
               
                   
                   
                   
                 414 421 428-429 438-440 443-444 454 456- 
               
               
                   
                   
                   
                 457 459 463 467 475 486 489 493 495 507 
               
               
                   
                   
                   
                 514-515 522 534-537 556 568 572 574 577 
               
               
                   
                   
                   
                 582-583 587 594 600 608 610 613 622 626 
               
               
                   
                   
                   
                 633 639 643 647-648 651 653 667 680 683 
               
               
                   
                   
                   
                 685-686 693 696 703-704 706 711 721 723- 
               
               
                   
                   
                   
                 725 727 730-731 734-735 742-743 748 754- 
               
               
                   
                   
                   
                 757 762 771 776 785-786 788 794 800 802 
               
               
                   
                   
                   
                 807 809-810 817 827 829 834-835 842 850 
               
               
                   
                   
                   
                 857 860 862-863 868 870 873 876-877 879- 
               
               
                   
                   
                   
                 880 884 887 891 897 904-905 910 916-917 
               
               
                   
                   
                   
                 921 925-926 933 937 947 
               
               
                 diaphragm 
                 BioChain 
                 DIA002 
                 305 311 
               
               
                 endothelial 
                 Stratagene 
                 EDT001 
                 1-2 7-8 14-16 19-22 24 28-29 32-33 41 43 
               
               
                 cells 
                   
                   
                 45 51 57 61 74 83 87-88 97 105 112 116-117 
               
               
                   
                   
                   
                 131 134 137 140 148 165 172 179 188-192 
               
               
                   
                   
                   
                 197-198 208 212-213 220-221 225 229 231 
               
               
                   
                   
                   
                 237 246 252 256-258 261-265 268-272 276- 
               
               
                   
                   
                   
                 277 279 281-282 284 286 288 294 297 299 
               
               
                   
                   
                   
                 302 307-308 311-313 326 334-335 340 355- 
               
               
                   
                   
                   
                 356 358 360-361 364 375 383 386 389 392 
               
               
                   
                   
                   
                 403 413 423-424 429 440 443 445 451 453 
               
               
                   
                   
                   
                 455-456 459-460 462-463 465-466 468-470 
               
               
                   
                   
                   
                 475 491 495 497-499 504 514 520-522 524- 
               
               
                   
                   
                   
                 526 528 532-536 539-540 546 551-552 554 
               
               
                   
                   
                   
                 556 564 566-567 571 574-577 581-583 587 
               
               
                   
                   
                   
                 591-593 597-599 601 607 615 618 622 625 
               
               
                   
                   
                   
                 633 639 641-644 651 667 677 680 684 691- 
               
               
                   
                   
                   
                 692 701-702 704 716-717 720-721 726 732- 
               
               
                   
                   
                   
                 733 735 743-744 754 758 765 785-786 795 
               
               
                   
                   
                   
                 802 806 809 819 826 828-830 832 834 836 
               
               
                   
                   
                   
                 846-847 850 867 871 877-878 890-891 897 
               
               
                   
                   
                   
                 902 907 921 923 925-926 944 946 
               
               
                 esophagus 
                 BioChain 
                 ESO002 
                 188 
               
               
                 fetal brain 
                 Clontech 
                 FBR001 
                 33 49 51 126 134 197-198 264-265 360-361 
               
               
                   
                   
                   
                 413 460 647 810 819 871 
               
               
                 fetal brain 
                 Clontech 
                 FBR004 
                 137 156 205 282 284 405 424 480 489 701- 
               
               
                   
                   
                   
                 702 820 921 
               
               
                 fetal brain 
                 Clontech 
                 FBR006 
                 2 9-10 18-19 22 28 30-32 37 39-40 42-43 
               
               
                   
                   
                   
                 46-47 49 57 66-67 76 80 83 96 109 112 116- 
               
               
                   
                   
                   
                 117 120 124 131 133-134 136 142-143 146 
               
               
                   
                   
                   
                 152 155 160 162 165 169 173 184 189-198 
               
               
                   
                   
                   
                 200-201 205 215-216 238 244 248 254-255 
               
               
                   
                   
                   
                 257-258 260-263 272-274 276-277 282 288 
               
               
                   
                   
                   
                 293-294 307 309 311 314-328 343 347 351- 
               
               
                   
                   
                   
                 352 354 357-358 360-361 373-375 378-381 
               
               
                   
                   
                   
                 390 392 400-401 403 405 407 410-411 413 
               
               
                   
                   
                   
                 420 424 429 445 450 452-453 458 460 463 
               
               
                   
                   
                   
                 467-469 472 474 477 479 483-484 491 499 
               
               
                   
                   
                   
                 507 520-521 525 527 529 531 533 538 545 
               
               
                   
                   
                   
                 551 562 564 566 571 574 579 581-583 587 
               
               
                   
                   
                   
                 591 599-600 604 606 611 626 629 631-632 
               
               
                   
                   
                   
                 638 643 651 654-655 657-660 672-673 676- 
               
               
                   
                   
                   
                 677 684 689 693-694 697 699 709 714-715 
               
               
                   
                   
                   
                 717 720-721 732-733 735 744 748 751-752 
               
               
                   
                   
                   
                 754 761 763 767 772 775 777-779 781 785- 
               
               
                   
                   
                   
                 786 790 792 802 804 808 810 820 824 826 
               
               
                   
                   
                   
                 838-840 850 858-860 864 866 872-873 881 
               
               
                   
                   
                   
                 891-892 901-902 904 910-911 913 917-918 
               
               
                   
                   
                   
                 920 925-926 933 939-941 946-947 
               
               
                 fetal brain 
                 Clontech 
                 FBRs03 
                 316-325 684 
               
               
                 fetal brain 
                 Invitrogen 
                 FBT002 
                 2-4 20-21 45 51 53 57 88 93 125-126 134 
               
               
                   
                   
                   
                 166 184 186 188 200 213 224 263 276-278 
               
               
                   
                   
                   
                 307 311 341 373 375 418-419 423 427 432 
               
               
                   
                   
                   
                 450 452 459-460 470 492 498-499 507 514 
               
               
                   
                   
                   
                 522 534-535 545 550-552 571 577 610 714 
               
               
                   
                   
                   
                 721 743 754 795 827 861 866 872-873 887 
               
               
                   
                   
                   
                 896 925-926 934 939-941 946 948 
               
               
                 fetal heart 
                 Invitrogen 
                 FHR001 
                 2-4 10 13 16-18 29 31-32 37-38 43 46 49 51 
               
               
                   
                   
                   
                 53 55-56 67-68 75 80 85 87 97 115 120 137 
               
               
                   
                   
                   
                 152 156 160-161 163 168-169 174 178 189- 
               
               
                   
                   
                   
                 192 196 200 216 220 225 252 262 276-277 
               
               
                   
                   
                   
                 282 288 301-302 305 311 315-325 333 343 
               
               
                   
                   
                   
                 351 357-358 360-361 368-372 378 424 436 
               
               
                   
                   
                   
                 440-441 445 453 460 469 478 483-484 495 
               
               
                   
                   
                   
                 520-521 527 533 538 541-543 546 556 564- 
               
               
                   
                   
                   
                 566 568 576 581 587 594-595 601-602 606 
               
               
                   
                   
                   
                 609 612 615 633 638 640 643 653-655 664- 
               
               
                   
                   
                   
                 665 672-673 677 684 691-693 697 704 707 
               
               
                   
                   
                   
                 709 717 735 738 744 746 748-749 751-752 
               
               
                   
                   
                   
                 754 761 777 779 781-782 785-786 797-798 
               
               
                   
                   
                   
                 820 824 826 829 834 838 841-847 850 875 
               
               
                   
                   
                   
                 877-878 893-894 897 901 910 913 925-927 
               
               
                   
                   
                   
                 936 946 
               
               
                 fetal kidney 
                 Clontech 
                 FKD001 
                 8 14-15 32 43 50 68 96 106 126 131 134 140 
               
               
                   
                   
                   
                 186 188 226-228 233 279 282 311 339 428 
               
               
                   
                   
                   
                 440 450 456 468 552 618 651 700 726 735 
               
               
                   
                   
                   
                 748 751 781 794 797-798 826 878 887 899 
               
               
                 fetal kidney 
                 Clontech 
                 FKD002 
                 50 83 96 131 134 143 163 172 193-194 201 
               
               
                   
                   
                   
                 203 215 263 273-274 311 316-325 339 360- 
               
               
                   
                   
                   
                 363 374 376-377 379-380 388 394 400-401 
               
               
                   
                   
                   
                 403 407 425 440 451 454 493 525 536-538 
               
               
                   
                   
                   
                 540-542 572 580 582-583 587 605-606 621 
               
               
                   
                   
                   
                 631-632 647 673 689 706 709 714 726 735 
               
               
                   
                   
                   
                 761 774 777 799 809 845-848 858 872 875 
               
               
                   
                   
                   
                 878-879 882 895 918 927 
               
               
                 fetal kidney 
                 Invitrogen 
                 FKD007 
                 66 214 
               
               
                 fetal lung 
                 Clontech 
                 FLG001 
                 65 179 213 223 340 360-361 491 564 577 591 
               
               
                   
                   
                   
                 627 646 650 712 715 744 758 939-941 
               
               
                 fetal lung 
                 Invitrogen 
                 FLG003 
                 49 54 75 97 137 148 152 188 197-199 213- 
               
               
                   
                   
                   
                 214 225 240 256 288 316-325 369 378 392 
               
               
                   
                   
                   
                 423 429 464 496 526 580-581 586 591 693 
               
               
                   
                   
                   
                 706 726-727 766 878 913 925-926 939-941 
               
               
                 fetal lung 
                 Clontech 
                 FLG004 
                 388 921 
               
               
                 fetal liver- 
                 Columbia 
                 FLS001 
                 1-23 25-39 41-43 45-46 49-65 76 83-84 87- 
               
               
                 spleen 
                 University 
                   
                 88 91 94 97 100 112 118 122 126 129-130 
               
               
                   
                   
                   
                 134 137 140 148 163 168 172 179 186 188- 
               
               
                   
                   
                   
                 189 191-192 197-198 200-201 213-214 216 
               
               
                   
                   
                   
                 221 225-229 231-232 235 242 252-253 256- 
               
               
                   
                   
                   
                 258 262-271 277 284 287-288 297 299 307- 
               
               
                   
                   
                   
                 309 311 315-326 330 355-356 360-362 370 
               
               
                   
                   
                   
                 373 378-380 388 392 394 396 400-402 413 
               
               
                   
                   
                   
                 426 428 436 440-441 443-447 450 454-455 
               
               
                   
                   
                   
                 457 459-460 463-465 467-469 475 477-478 
               
               
                   
                   
                   
                 489-509 511-514 519-521 525-527 529-535 
               
               
                   
                   
                   
                 537 539 542 545 551-552 555-556 559 561 
               
               
                   
                   
                   
                 567 569 571 576-577 580-583 586-587 589 
               
               
                   
                   
                   
                 591-592 595 598-602 605 607 610 612-613 
               
               
                   
                   
                   
                 618-619 623 625-626 631-632 638-640 642- 
               
               
                   
                   
                   
                 644 646-647 649 651-652 654-655 667 673 
               
               
                   
                   
                   
                 676 680-681 683-684 700 703-704 706 711 
               
               
                   
                   
                   
                 715-718 720-721 726 732-735 740 742-744 
               
               
                   
                   
                   
                 748 754 756-758 763-765 771 774-775 777- 
               
               
                   
                   
                   
                 782 785-786 790 793-795 797-798 806-808 
               
               
                   
                   
                   
                 815 818 824-826 829-830 834-835 837 841 
               
               
                   
                   
                   
                 846-847 849-850 856 860-861 866 870-872 
               
               
                   
                   
                   
                 876 878 881-883 888 894 897-898 902 905 
               
               
                   
                   
                   
                 907 910 919 924-926 929 933 942 947 
               
               
                 fetal liver- 
                 Columbia 
                 FLS002 
                 1 3-4 11-12 14-17 20-23 26-29 32-34 38 41 
               
               
                 spleen 
                 University 
                   
                 43 45-47 49 51-52 55-62 65-67 76 83-85 87- 
               
               
                   
                   
                   
                 88 90-91 95 97-99 104-105 112 114-117 126 
               
               
                   
                   
                   
                 130 133 150 163 165 172 178 186-187 193- 
               
               
                   
                   
                   
                 194 200-202 208 213 221 225 229 232-235 
               
               
                   
                   
                   
                 244-246 248-253 256-257 262-265 267-271 
               
               
                   
                   
                   
                 273-274 284 287 299 311 315 326 335 337- 
               
               
                   
                   
                   
                 338 343 355-356 358 375-378 381 392 394 
               
               
                   
                   
                   
                 400-402 414 416 426 428-429 440-442 444- 
               
               
                   
                   
                   
                 447 453-455 457 459 461 464-465 467 476- 
               
               
                   
                   
                   
                 477 483-484 489-490 492 495 497-500 504 
               
               
                   
                   
                   
                 506-507 509 511-514 519 522 524 526 532- 
               
               
                   
                   
                   
                 535 537 539-540 542 545 551-552 556 567 
               
               
                   
                   
                   
                 569 574 576-577 581 589-590 592 599 601- 
               
               
                   
                   
                   
                 602 605 607 610 612-613 619-620 625 627 
               
               
                   
                   
                   
                 629 631-632 638 640-641 646 648-649 654- 
               
               
                   
                   
                   
                 655 667 670 683-684 687-688 693 696 700 
               
               
                   
                   
                   
                 703-706 713 716-721 726 734-735 740 742 
               
               
                   
                   
                   
                 744 748 754 758 771 775 777-778 780-782 
               
               
                   
                   
                   
                 785-787 790-792 794-799 801-802 806 808 
               
               
                   
                   
                   
                 818 824 829 835 849-850 852-855 857 870- 
               
               
                   
                   
                   
                 871 876 882-884 886 888 890 894 897-898 
               
               
                   
                   
                   
                 900 902-903 907 919 921 923-926 929-930 
               
               
                   
                   
                   
                 933 938-942 
               
               
                 fetal liver- 
                 Columbia 
                 FLS003 
                 30 34 67 85 88 89 130 172 188-189 191-192 
               
               
                 spleen 
                 University 
                   
                 213 229 231 257 311 315-325 329 331 335 
               
               
                   
                   
                   
                 362 391 394 400-402 423 441 455 457 461 
               
               
                   
                   
                   
                 476 498 500 511 523 531-532 537 542 576 
               
               
                   
                   
                   
                 587 592 612-613 625 649 665-666 703 719 
               
               
                   
                   
                   
                 731 733 740 744 771 775 777-778 787 797- 
               
               
                   
                   
                   
                 798 819 824 826 850 854-856 861 863 870 
               
               
                   
                   
                   
                 879 884 897 923 931-933 947 
               
               
                 fetal liver 
                 Invitrogen 
                 FLV001 
                 2 7 19 28 35-37 47 52 54-56 66 95 134 139 
               
               
                   
                   
                   
                 179 188-192 200 213 218 263 272 288 294 
               
               
                   
                   
                   
                 305 311 315 349 378-381 388 392 403 426 
               
               
                   
                   
                   
                 443 454 459-460 469 496-499 514 527 529 
               
               
                   
                   
                   
                 532 534-535 555 586 605 640 644 658-659 
               
               
                   
                   
                   
                 673 680 687 698 713 715 720-721 723 726 
               
               
                   
                   
                   
                 754 758 778 795 817-818 829 853 861 868 
               
               
                   
                   
                   
                 870-871 897 903 933 
               
               
                 fetal liver 
                 Clontech 
                 FLV002 
                 52 189-192 219 297 308 335 364 378 427 828 
               
               
                 fetal liver 
                 Clontech 
                 FLV004 
                 2 19 28-29 37 39 49 52-53 55-56 62 65-66 
               
               
                   
                   
                   
                 76 87 124 134 137 139 142 179 188 195 208 
               
               
                   
                   
                   
                 216 219 244 252 263 268-270 272 277 287- 
               
               
                   
                   
                   
                 288 294 303 305 311 315-325 339 355-356 
               
               
                   
                   
                   
                 358 360-361 368 374 378 403 441 454-455 
               
               
                   
                   
                   
                 460 477 483-484 497 514 520-521 542 553 
               
               
                   
                   
                   
                 582-583 587 591 594 611-613 620-621 638- 
               
               
                   
                   
                   
                 639 654-655 658-659 681 684 687-688 709 
               
               
                   
                   
                   
                 721 730 738 744 752 754 781 793 802 813 
               
               
                   
                   
                   
                 818 826 832 836 854-855 876 878 893 897 
               
               
                   
                   
                   
                 900 910 924 933 944 
               
               
                 fetal muscle 
                 Invitrogen 
                 FMS001 
                 28 65 115 121 126 134 137 156 168 172-173 
               
               
                   
                   
                   
                 181 213-214 225 263 267 305 340-341 360- 
               
               
                   
                   
                   
                 361 440 459 516 534-535 543 564 586 606 
               
               
                   
                   
                   
                 609-610 623 650 676 683 754 766 853 871 
               
               
                   
                   
                   
                 886 894 930 934-935 948 
               
               
                 fetal muscle 
                 Invitrogen 
                 FMS002 
                 19-21 41 49 51 53 57 75 96 101 103 112 134 
               
               
                   
                   
                   
                 136 156 171 184 188 191-192 212 216 250 
               
               
                   
                   
                   
                 262 267 276 305 311 342 348-350 355-356 
               
               
                   
                   
                   
                 360-361 374 392 403 411 415 423 425 457 
               
               
                   
                   
                   
                 469 491 495 499 508 515 517 534-536 543 
               
               
                   
                   
                   
                 546 564 566 576 580 582-583 587 594 599 
               
               
                   
                   
                   
                 609 611 615 618 623 644 647 658-659 664 
               
               
                   
                   
                   
                 668-669 677 683 691-692 696 703 735 743 
               
               
                   
                   
                   
                 754 766 788 802 817 826 828 850 877-879 
               
               
                   
                   
                   
                 894 910 925-926 935 
               
               
                 fetal skin 
                 Invitrogen 
                 FSK001 
                 3-7 18 24 27 29 35-37 51 53 55-56 66-67 76 
               
               
                   
                   
                   
                 90 95 97 122 126 134 136-137 166-167 181 
               
               
                   
                   
                   
                 188-192 208 213-214 224-225 245 250 252 
               
               
                   
                   
                   
                 257 260 262 268-271 273-274 282 284 297 
               
               
                   
                   
                   
                 302 312-313 315-326 341 367 373 375 378 
               
               
                   
                   
                   
                 383 387-388 390 394 423 429 440-441 450 
               
               
                   
                   
                   
                 454-455 457 459 463-464 470 472 475 486 
               
               
                   
                   
                   
                 489 492 495 498-500 511 514 524 527 530- 
               
               
                   
                   
                   
                 532 534-535 541-542 545 550 552 555-556 
               
               
                   
                   
                   
                 565 571 586 589 591-592 602 604 606 610 
               
               
                   
                   
                   
                 613 618 622-623 626 631-632 640 651 654- 
               
               
                   
                   
                   
                 655 672-673 685-686 693 701-702 704 706 
               
               
                   
                   
                   
                 717-718 720 723 727-728 744 754 762 764- 
               
               
                   
                   
                   
                 766 768-771 795 809 814 821 824 827 843 
               
               
                   
                   
                   
                 853 868 870-874 887-888 890 897 902 907 
               
               
                   
                   
                   
                 925-926 928 930 933-934 939-941 944-945 
               
               
                   
                   
                   
                 947 
               
               
                 fetal skin 
                 Invitrogen 
                 FSK002 
                 2 5-6 19 29 34 51 57 59 88 97 101 124 131 
               
               
                   
                   
                   
                 134 143 163 166 172 189 191-192 196 212 
               
               
                   
                   
                   
                 216 222-223 231 250 257 263 268-272 282 
               
               
                   
                   
                   
                 284 287-288 294 297 299 302 304 310-311 
               
               
                   
                   
                   
                 316-325 328 333 340 352 360-361 365-367 
               
               
                   
                   
                   
                 372 379-380 388 390 400-401 403 410-411 
               
               
                   
                   
                   
                 440 449-450 454 457 463 470 478 491 495 
               
               
                   
                   
                   
                 500 505 515 520-521 524 532 534-535 541 
               
               
                   
                   
                   
                 555 560 562 564 572 576 581 592 595 599 
               
               
                   
                   
                   
                 611 622 626 630 636 640 642 650 664 677 
               
               
                   
                   
                   
                 683 691-693 696 699 701-702 708-709 715 
               
               
                   
                   
                   
                 721 723 728 735 744 747-748 750 754 766 
               
               
                   
                   
                   
                 779 782 799 803 807 813 820 824 826 834 
               
               
                   
                   
                   
                 846-847 867-868 872-874 878-879 890-891 
               
               
                   
                   
                   
                 897 901 904 907 910 912 916 918 925-926 
               
               
                   
                   
                   
                 933 944-945 
               
               
                 fetal spleen 
                 BioChain 
                 FSP001 
                 311 748 
               
               
                 umbilical cord 
                 BioChain 
                 FUC001 
                 1-2 29 32 46 67 83 87 94 134 136 140 148 
               
               
                   
                   
                   
                 160 163 166 172 181 186-192 197-198 208 
               
               
                   
                   
                   
                 213 216 225-231 237 252 261-265 267-270 
               
               
                   
                   
                   
                 279 282 288 295 302 308 311 316-326 339- 
               
               
                   
                   
                   
                 340 365 376-377 379-380 384 392-397 421 
               
               
                   
                   
                   
                 423 428 433 440 445 452 459 461 463-464 
               
               
                   
                   
                   
                 470 472 489 491 495 497 500 507 517-518 
               
               
                   
                   
                   
                 522 525-526 528 534-535 540 545-546 556- 
               
               
                   
                   
                   
                 558 564 566 568 571-572 577 592 599 601 
               
               
                   
                   
                   
                 605 610 618 623 644 651 661 668-669 673 
               
               
                   
                   
                   
                 678 680 685-686 696 706 709 718 735-736 
               
               
                   
                   
                   
                 748 754 769 772-777 782 792 797-799 802 
               
               
                   
                   
                   
                 807 809 815 817 824 850 854-855 870 876 
               
               
                   
                   
                   
                 881 888 891 897 899 901 913 921 928 930- 
               
               
                   
                   
                   
                 932 
               
               
                 fetal brain 
                 GIBCO 
                 HFB001 
                 2 12 16-17 19 23 27-28 32-33 39 41-45 49 
               
               
                   
                   
                   
                 87-89 94 97 100 107 112 130-131 134 142 
               
               
                   
                   
                   
                 157 163 172 188-192 200 216 224-225 231 
               
               
                   
                   
                   
                 237 242 246 252 258 261 263-265 271 273- 
               
               
                   
                   
                   
                 274 276-277 288 295 299 301 307 311 314- 
               
               
                   
                   
                   
                 326 328 341 355-356 373 375 387 389 392 
               
               
                   
                   
                   
                 395 424-425 431 438 445 450-452 457 459- 
               
               
                   
                   
                   
                 460 468-469 475 489 491 495 500 504 511 
               
               
                   
                   
                   
                 514 520-529 531 533 540-542 545 552 554 
               
               
                   
                   
                   
                 557-558 566 576-577 579-584 587 591 596 
               
               
                   
                   
                   
                 598-599 606 613 626 631-632 643 651 664 
               
               
                   
                   
                   
                 668 673 676 680 693-694 696 703-704 716- 
               
               
                   
                   
                   
                 717 721 727 735 738 740 744 748 757-758 
               
               
                   
                   
                   
                 769 774 778 780-781 810 827-828 830 850 
               
               
                   
                   
                   
                 869 871-872 876 878-879 884 890 892 897 
               
               
                   
                   
                   
                 899 904 906-907 913 916 918 920 924 928 
               
               
                   
                   
                   
                 934 938 946 
               
               
                 macrophage 
                 Invitrogen 
                 HMP001 
                 49 97 208 252 301 306 311 316-325 337-338 
               
               
                   
                   
                   
                 345-346 416 512 522 572 670 716 743 785- 
               
               
                   
                   
                   
                 786 802 888 919 923 
               
               
                 infant brain 
                 Columbia 
                 IB2002 
                 2-4 12 14-15 20-21 23-24 27 29 31-32 39 41 
               
               
                   
                 University 
                   
                 46 48-49 51 53 55-56 66 75-76 86-88 93 95 
               
               
                   
                   
                   
                 101 105 108-109 116-117 125 127 129 131 
               
               
                   
                   
                   
                 136 145 163 166 170 180-181 186 188-189 
               
               
                   
                   
                   
                 191-192 200-201 207-208 212-214 216 220 
               
               
                   
                   
                   
                 224 229 231 245 247 252 257 259 264-265 
               
               
                   
                   
                   
                 267 271 279 282 288 293 295 299-300 311 
               
               
                   
                   
                   
                 314-326 337-338 340 349 367 373 375 388 
               
               
                   
                   
                   
                 390-393 396 402 405 407 418-421 424 428- 
               
               
                   
                   
                   
                 429 431 433 436 450 452-453 457 459 463 
               
               
                   
                   
                   
                 468 489 495 496-500 507 511 522-524 526 
               
               
                   
                   
                   
                 528-530 532 541-542 545-546 552 557-558 
               
               
                   
                   
                   
                 562 564-566 571 577-583 587 589-591 599- 
               
               
                   
                   
                   
                 601 606 608 613-614 619 631-632 647 654- 
               
               
                   
                   
                   
                 655 658-659 667 676 684 691-693 696 700 
               
               
                   
                   
                   
                 704 711 718 721 723 725 740-741 743-744 
               
               
                   
                   
                   
                 748 754 775 777-778 780 788 792-793 795 
               
               
                   
                   
                   
                 802 805 808 819 826-829 834 836 838 861 
               
               
                   
                   
                   
                 863 869-870 875 879 881-882 884 887 890- 
               
               
                   
                   
                   
                 891 893 897 902 920-921 925-926 934 938- 
               
               
                   
                   
                   
                 941 946 
               
               
                 infant brain 
                 Columbia 
                 IB2003 
                 2 27 37 39 43 48-49 51 53 85-87 97 106 113 
               
               
                   
                 University 
                   
                 124 126-127 131 142 166 170 188 200-201 
               
               
                   
                   
                   
                 208 214-215 220 224 226-228 231 251 257 
               
               
                   
                   
                   
                 263 267 271-272 279 288 293 299 311 314- 
               
               
                   
                   
                   
                 326 337-339 349 360-361 367 386 392 397 
               
               
                   
                   
                   
                 400-402 407 410 418-419 424-425 427 429 
               
               
                   
                   
                   
                 452 454 460 475 489 495 497-500 507 522- 
               
               
                   
                   
                   
                 523 525 529 532 539 542 545-546 551-552 
               
               
                   
                   
                   
                 557-558 564-565 578 582-583 585 591 601 
               
               
                   
                   
                   
                 606 625-626 631-633 643-644 673 690-693 
               
               
                   
                   
                   
                 701-702 706 711 721 723 734 740-741 743- 
               
               
                   
                   
                   
                 744 748 751 754 761 778 788 795 802 808 
               
               
                   
                   
                   
                 819 826-827 829 837 843 869-871 875 878- 
               
               
                   
                   
                   
                 880 884 896-897 902 920 933-934 946 
               
               
                 infant brain 
                 Columbia 
                 IBM002 
                 32 43 66 340 387 541 562 693 712 751 795 
               
               
                   
                 University 
                   
                 829 871 920 925-927 929 
               
               
                 infant brain 
                 Columbia 
                 IBS001 
                 2 29 37 39 76 142 163 392 455 495 499 606 
               
               
                   
                 University 
                   
                 681 741 754 778 
               
               
                 lung, 
                 Stratagene 
                 LFB001 
                 2-4 22 28 32-33 47 51 79 120 129 134 140 
               
               
                 fibroblast 
                   
                   
                 163 172 188 208 220-221 231 252 257 263 
               
               
                   
                   
                   
                 276-277 284 307 375 378-380 396 423 428 
               
               
                   
                   
                   
                 440 450 459 463 486 491 493 495 499 539 
               
               
                   
                   
                   
                 571 591 601 607 613 615 618 625 639 651 
               
               
                   
                   
                   
                 684 716-717 721 727 735 748 782 828 850 
               
               
                   
                   
                   
                 870-871 
               
               
                 lung tumor 
                 Invitrogen 
                 LGT002 
                 2 5-8 13 16-17 29-31 35-39 43 46 57 67 72 
               
               
                   
                   
                   
                 76 78 81 85 87 90 94 97 100 110 119 122 
               
               
                   
                   
                   
                 130-131 134 137 140 146 149 167 172 174 
               
               
                   
                   
                   
                 179 188 197-198 201 213 216 218 220-221 
               
               
                   
                   
                   
                 223 231 245-246 251-252 256-257 262-263 
               
               
                   
                   
                   
                 267-270 277 284 288 296 299 301-302 311 
               
               
                   
                   
                   
                 316-325 340 354 373 379-380 388 392 395 
               
               
                   
                   
                   
                 400-401 410 413 421 431 436 441-443 445 
               
               
                   
                   
                   
                 451 455 457 460 463-464 467 469 475 478 
               
               
                   
                   
                   
                 489 491 493 497 499 504 507 514 518-519 
               
               
                   
                   
                   
                 524 529 534-535 537 542 545-546 548 552 
               
               
                   
                   
                   
                 555 559 568 578 581-583 592 597 602-603 
               
               
                   
                   
                   
                 605-607 613 615 619 621-622 636-637 642- 
               
               
                   
                   
                   
                 643 646-647 654-655 679-681 684 687-689 
               
               
                   
                   
                   
                 693 701-702 704 706 711 713 715-716 718 
               
               
                   
                   
                   
                 727 732-734 738 748 753-754 757-758 760 
               
               
                   
                   
                   
                 762 766 769 774 782 785-786 802 817 829 
               
               
                   
                   
                   
                 834 850 853 859-860 866-867 870-871 878- 
               
               
                   
                   
                   
                 879 887 890 899 902 904 910 917 923 925- 
               
               
                   
                   
                   
                 926 936-937 
               
               
                 lymphocytes 
                 ATCC 
                 LPC001 
                 2 16 19-21 25 31-32 49 53 55-56 63 67 85- 
               
               
                   
                   
                   
                 87 90 97 120 122 137 140 163 165 168 172 
               
               
                   
                   
                   
                 188 197-198 215-216 221 229 231 236-238 
               
               
                   
                   
                   
                 248 252 256 272-274 283-284 288 294 299 
               
               
                   
                   
                   
                 316-326 343 368 374 378 395 423 431 454- 
               
               
                   
                   
                   
                 455 467 469 476 478 491 495 498 505 512 
               
               
                   
                   
                   
                 515 517-518 520-522 524 526 529 531-532 
               
               
                   
                   
                   
                 537 539 542 545-546 551 556 571 577 580 
               
               
                   
                   
                   
                 589-590 592 596 601 622 631-632 640 642 
               
               
                   
                   
                   
                 654-655 664 666 668-669 673 684 703 708 
               
               
                   
                   
                   
                 716 718 721 723 727 733 735 743-744 754 
               
               
                   
                   
                   
                 758 765 771 775 777-779 783-786 797-799 
               
               
                   
                   
                   
                 810 816-817 828 834 845 859 861 863 870 
               
               
                   
                   
                   
                 878-879 881 884 887 890 897 904 907 910 
               
               
                   
                   
                   
                 912-913 918 923 929 939-942 945-947 
               
               
                 leukocyte 
                 GIBCO 
                 LUC001 
                 2-4 7-8 13-17 20-23 31-33 38 43 48-49 51 
               
               
                   
                   
                   
                 53-57 63 66-68 74-78 85-88 93 97 122 124 
               
               
                   
                   
                   
                 129 131-132 134 137 140 163 166 168 171- 
               
               
                   
                   
                   
                 172 175 188-192 197 200 208-213 216 221 
               
               
                   
                   
                   
                 223 231 236 242 252 257-258 261-263 268- 
               
               
                   
                   
                   
                 270 272 277 279 287-288 294 307 311 314 
               
               
                   
                   
                   
                 316-326 329 337-339 341 373-374 376-377 
               
               
                   
                   
                   
                 381 388-392 396 400-401 413-414 423 436 
               
               
                   
                   
                   
                 441 450 454-455 459 463 465 467 489 491- 
               
               
                   
                   
                   
                 493 495 498-499 504-505 507 514 518 520- 
               
               
                   
                   
                   
                 522 524 526 529 531 533 536-537 539-540 
               
               
                   
                   
                   
                 545 552-554 556 568 571 577 580 585 589- 
               
               
                   
                   
                   
                 590 596 599 602 605 607 610 612-613 615 
               
               
                   
                   
                   
                 618-619 621-622 625 638 640 642-644 664 
               
               
                   
                   
                   
                 667 677-678 684 690-693 696 700 703-704 
               
               
                   
                   
                   
                 707 713 715-718 721 727 734-735 738 740- 
               
               
                   
                   
                   
                 746 748 753-754 758 775 778 780 789 794 
               
               
                   
                   
                   
                 797-798 801-802 815 817 825 827 829 834 
               
               
                   
                   
                   
                 836 846-847 850 859-861 863-864 866-867 
               
               
                   
                   
                   
                 871-872 878 884 886-888 891 896-897 902 
               
               
                   
                   
                   
                 904 910 913 916 921 923-926 929-932 936 
               
               
                   
                   
                   
                 943 
               
               
                 leukocyte 
                 Clontech 
                 LUC003 
                 12 14-15 18 32 111 134 137 172 221 277 280 
               
               
                   
                   
                   
                 311 316-325 436 454 467 549 552 568 585 
               
               
                   
                   
                   
                 603 643 691-692 698-699 734 744 751 754 
               
               
                   
                   
                   
                 784 797-798 861 897 916 923 
               
               
                 Melanoma from 
                 Clontech 
                 MEL004 
                 3-4 16 20-21 43 46 48 97 103 147 163 188 
               
               
                 cell line ATCC 
                   
                   
                 191 213 216 221 231 241 245-246 260 262- 
               
               
                 CRL #1424 
                   
                   
                 263 316-325 381 407 431 504 525 527 542 
               
               
                   
                   
                   
                 556 568 577 589 596 607 613 676 693 714 
               
               
                   
                   
                   
                 735 737-739 744 758-760 775 822 850 863 
               
               
                   
                   
                   
                 878 887 897 
               
               
                 mammary gland 
                 Invitrogen 
                 MMG001 
                 1-8 14-18 20-21 25 28-29 37 39 43 49 51-57 
               
               
                   
                   
                   
                 60 66-67 72 75-76 87 95 97 103-104 106 112 
               
               
                   
                   
                   
                 115 119 122 127 130 134 137 139 142 150 
               
               
                   
                   
                   
                 166-168 172 175 184 186 188-189 191-192 
               
               
                   
                   
                   
                 200 213-214 222-224 226-229 240 252 257- 
               
               
                   
                   
                   
                 259 263 267 271 276 278 282 287-288 299 
               
               
                   
                   
                   
                 301-302 305 307-308 311-313 316-325 327- 
               
               
                   
                   
                   
                 328 332 340-341 358 360-362 369 373 378 
               
               
                   
                   
                   
                 381 383 388 390-392 397 402-403 409 415- 
               
               
                   
                   
                   
                 416 423 425 428-429 433 436 444 454-456 
               
               
                   
                   
                   
                 459-460 464 467 469 481 483-484 486 493 
               
               
                   
                   
                   
                 495 498-499 515 524-525 529-530 532-537 
               
               
                   
                   
                   
                 541-542 545 551-552 562 582-583 586-587 
               
               
                   
                   
                   
                 593 599-600 602 604-605 610 618-619 622 
               
               
                   
                   
                   
                 625-627 634 644 646-647 652 654-655 662 
               
               
                   
                   
                   
                 673 676 680 684 687-688 691-692 701-703 
               
               
                   
                   
                   
                 715 717 721 723 726 735 743 751 754 758 
               
               
                   
                   
                   
                 765-766 771 777-778 789 803 805 807 809- 
               
               
                   
                   
                   
                 811 821 827 829 850 860 887-888 892 896 
               
               
                   
                   
                   
                 898 901-902 905 911 913 917 925-926 930 
               
               
                   
                   
                   
                 936 939-942 
               
               
                 induced neuron 
                 Stratagene 
                 NTD001 
                 2 16 32 51 66 88 97 124 130 134 137 172 
               
               
                 cells 
                   
                   
                 188-189 191-192 231 252 257 260 277 291 
               
               
                   
                   
                   
                 373 424 431 454 460 489 495 523 525 582- 
               
               
                   
                   
                   
                 583 591 631-632 643 649 670 695 725-726 
               
               
                   
                   
                   
                 735 765 789 797-798 837 850 878 884 888 
               
               
                   
                   
                   
                 890 913 929 946 
               
               
                 retinoid acid 
                 Stratagene 
                 NTR001 
                 2 5-6 20-22 136-137 188-194 197-198 224 
               
               
                 induced 
                   
                   
                 311 375 381 410 457 462 475 495 531 546 
               
               
                 neuronal cells 
                   
                   
                 548 552 599 618 678 743 752 819 828 890 
               
               
                   
                   
                   
                 895 897 930 934 938 944 946 
               
               
                 neuronal cells 
                 Stratagene 
                 NTU001 
                 2 5-6 20-21 55-56 87 137 188-192 197-198 
               
               
                   
                   
                   
                 215-216 260 287 291 310-311 316-325 365 
               
               
                   
                   
                   
                 375 423 457 459 470 499 532 542 564 576 
               
               
                   
                   
                   
                 598-599 623 643 651-652 673 721 726 743 
               
               
                   
                   
                   
                 745 752 754 765 780 787 789 822 829 870 
               
               
                   
                   
                   
                 875 888 896 917 919 929 
               
               
                 pituitary gland 
                 Clontech 
                 PIT004 
                 41-42 83 85 97 134 193-194 204 208 213 224 
               
               
                   
                   
                   
                 257-258 263-265 285-286 308 311 360-361 
               
               
                   
                   
                   
                 413 443 445 491 514 529 532 639 644 647 
               
               
                   
                   
                   
                 682 701-702 716 781 822 829 836 850 933 
               
               
                   
                   
                   
                 939-941 947 
               
               
                 placenta 
                 Clontech 
                 PLA003 
                 16 31 34 49 66 80 87 97 101-102 134 158 
               
               
                   
                   
                   
                 165 172 179 184 188 197-198 209-210 218 
               
               
                   
                   
                   
                 220 229 235 249 256 267-270 277 287-288 
               
               
                   
                   
                   
                 302 307 332 360-361 365 388 394 414 441 
               
               
                   
                   
                   
                 444 454 457 460 493 498-500 505-506 509 
               
               
                   
                   
                   
                 529 531-532 550 559-560 564 572 587 601 
               
               
                   
                   
                   
                 625 630-632 638 672 682-684 689 706 708 
               
               
                   
                   
                   
                 726 733 735 744 754 761 784-786 793 863 
               
               
                   
                   
                   
                 875 897 924 929 937 
               
               
                 prostate 
                 Clontech 
                 PRT001 
                 7-8 51 85 87 97 100 122 134 139 214 216 
               
               
                   
                   
                   
                 221 231 257 271 276 335 337-338 392 400- 
               
               
                   
                   
                   
                 401 431 440 459 477 530 534-535 546 556 
               
               
                   
                   
                   
                 582-583 599 622 631-632 639 651 663-664 
               
               
                   
                   
                   
                 673 683 707 715 735 740 765 773-774 777 
               
               
                   
                   
                   
                 810 823 897 909 919 934 939-941 947 
               
               
                 rectum 
                 Invitrogen 
                 REC001 
                 18 54 66 134 137 169 188 200 213 225 251 
               
               
                   
                   
                   
                 263 288 311-313 316-325 340 388 423 429 
               
               
                   
                   
                   
                 441 454 459 514 532 542 610 626 646 651 
               
               
                   
                   
                   
                 657 715 719 723 728 735 740 758 766 785- 
               
               
                   
                   
                   
                 786 823 829 833 836 886 942 
               
               
                 salivary gland 
                 Clontech 
                 SAL001 
                 31 49 78 95 134 136-137 143 176 188 208 
               
               
                   
                   
                   
                 223 244 268-270 284 308 311 316-325 388- 
               
               
                   
                   
                   
                 389 391 436 441 459 476 514-515 520-521 
               
               
                   
                   
                   
                 532 543 568 589 596 610 619 684 691-692 
               
               
                   
                   
                   
                 713 718 727 736 754 777 824 836 864 867 
               
               
                   
                   
                   
                 878 883 897 901-902 916-917 933 938-941 
               
               
                 salivary gland 
                 Clontech 
                 SALs03 
                 460 
               
               
                 skin fibroblast 
                 ATCC 
                 SFB001 
                 379-380 850 
               
               
                 skin fibroblast 
                 ATCC 
                 SFB002 
                 742 850 
               
               
                 skin fibroblast 
                 ATCC 
                 SFB003 
                 87 
               
               
                 small intestine 
                 Clontech 
                 SIN001 
                 27-29 31 38 40 46 48 51 54 57-58 62 65 67 
               
               
                   
                   
                   
                 75 77 85 97 110 112 116-117 119 131-132 
               
               
                   
                   
                   
                 134 137 140 161 163 166 168 177 188 197- 
               
               
                   
                   
                   
                 198 208 213 220 224 229 246 257 261-262 
               
               
                   
                   
                   
                 264-265 276-277 288 295 297 299 311 316- 
               
               
                   
                   
                   
                 326 328-330 337-338 340 360-361 373 375 
               
               
                   
                   
                   
                 382 390-391 410 413 428-429 436 438 440 
               
               
                   
                   
                   
                 453-454 459 468 476-477 497 507 511 522 
               
               
                   
                   
                   
                 531 536 538 542 545-546 548 552 556 564 
               
               
                   
                   
                   
                 570-571 576 580-581 586-587 591 596 599 
               
               
                   
                   
                   
                 605 610 613 619 625-626 643-644 651-653 
               
               
                   
                   
                   
                 664-666 668-670 677 680 684 693 700-702 
               
               
                   
                   
                   
                 706-707 713-715 723-724 729-730 735 740 
               
               
                   
                   
                   
                 746 748 753-754 757-758 764 777-778 784- 
               
               
                   
                   
                   
                 786 818 822 824 826-829 833-837 842 862- 
               
               
                   
                   
                   
                 863 865-867 877-878 886 897 900-902 906 
               
               
                   
                   
                   
                 913 916 921 925-926 936 939-941 
               
               
                 skeletal muscle 
                 Clontech 
                 SKM001 
                 42 98 156 163 191-192 200 261 305 311 395 
               
               
                   
                   
                   
                 415 462 468 504 531 543 566 582-583 585 
               
               
                   
                   
                   
                 594 680 740 853 875 927 933 935 
               
               
                 skeletal muscle 
                 Clontech 
                 SKM002 
                 850 
               
               
                 spinal cord 
                 Clontech 
                 SPC001 
                 18 23 33 37 42 51 67 87 92 94 97 100 140 
               
               
                   
                   
                   
                 162 184 188 191-192 208 213 220 231 248 
               
               
                   
                   
                   
                 262 268-271 273-274 282 287-288 290 307 
               
               
                   
                   
                   
                 311 316-325 358 364 376-377 383 387 389- 
               
               
                   
                   
                   
                 390 402 412 422 444 455 476 483-484 489 
               
               
                   
                   
                   
                 504 522 534-535 556 562 587-588 591 597 
               
               
                   
                   
                   
                 603-604 618-619 643 651 667-670 677 693 
               
               
                   
                   
                   
                 703-704 717-718 727 746 757 773 808 810 
               
               
                   
                   
                   
                 827 834-835 837 850 871-872 875 904 910 
               
               
                   
                   
                   
                 931-932 939-941 
               
               
                 adult spleen 
                 Clontech 
                 SPLc01 
                 33 38 57 67 75 87 134 142 163 216 221 229 
               
               
                   
                   
                   
                 244 257 304 307 311 316-325 340 355-356 
               
               
                   
                   
                   
                 378 441 468 525 538 545 560 564 599 721 
               
               
                   
                   
                   
                 754 766 780 794 827 841 850 866 
               
               
                 stomach 
                 Clontech 
                 STO001 
                 18 65 88 163 188 208 213 261 272 277 286 
               
               
                   
                   
                   
                 294 336 373 396 412 459 514 553 602 610 
               
               
                   
                   
                   
                 647 651-652 671 673 714 774 790 831 833 
               
               
                   
                   
                   
                 842 850 876 
               
               
                 thalamus 
                 Clontech 
                 THA002 
                 2 87 96 103 106 189-192 208 252 258 295 
               
               
                   
                   
                   
                 308 311 367 376-377 383-384 445 455 459- 
               
               
                   
                   
                   
                 460 498 529 587 598 602 629 654-655 705- 
               
               
                   
                   
                   
                 706 715 717 723 754 775 810 817 822 864 
               
               
                   
                   
                   
                 867 881 892 927 930 
               
               
                 thymus 
                 Clontech 
                 THM001 
                 3-4 8 18 28 54 57 63 65 68 84 97 100 116- 
               
               
                   
                   
                   
                 117 122 134 142 151 169 171-172 188 195 
               
               
                   
                   
                   
                 197-198 201 213 221 237 245 261 287 311 
               
               
                   
                   
                   
                 316-325 360-361 376-377 423 441 444 459 
               
               
                   
                   
                   
                 489 491-493 495 498 504 507 514 527 532 
               
               
                   
                   
                   
                 534-536 539 553 556 568 571-572 590 595- 
               
               
                   
                   
                   
                 596 599 610 618 622 631-632 643 647 651 
               
               
                   
                   
                   
                 654-655 664 687-688 691-693 703 715 721 
               
               
                   
                   
                   
                 733-735 748 760 762 765 781 794 799 802 
               
               
                   
                   
                   
                 831 834 836 842 850 860-861 863 871 878 
               
               
                   
                   
                   
                 885 896-897 903 910 923 925-926 928 939- 
               
               
                   
                   
                   
                 941 
               
               
                 thymus 
                 Clontech 
                 THMc02 
                 2-4 17 20-22 37-38 42-43 46 63 65-68 76 88 
               
               
                   
                   
                   
                 95 103 118 120 124 134 137 140-141 143 163 
               
               
                   
                   
                   
                 165 171 179 182 189-194 198 200 212-215 
               
               
                   
                   
                   
                 221 226-228 231 244 257 262 266 276-277 
               
               
                   
                   
                   
                 287-288 297 299 307 316-325 341 352 358 
               
               
                   
                   
                   
                 360-361 373 376-377 379-381 389 391 394- 
               
               
                   
                   
                   
                 396 403 410-411 436 440 445 450 459 463- 
               
               
                   
                   
                   
                 464 469 478 491 495 500 507 511 519-521 
               
               
                   
                   
                   
                 530 532 539 542 550 555 560 563 576 581 
               
               
                   
                   
                   
                 587 595 601 610-611 613-614 618 622 625- 
               
               
                   
                   
                   
                 626 631-632 638 642-644 657 664 667 670 
               
               
                   
                   
                   
                 673 680 683 687 691-693 699 715-716 721 
               
               
                   
                   
                   
                 740 743-744 747-754 761 763-765 771 777 
               
               
                   
                   
                   
                 780-781 784-787 790 794 805 811 820 826 
               
               
                   
                   
                   
                 831 834 841 845 861 867-868 878 881 883 
               
               
                   
                   
                   
                 891 893-894 896-897 902 904 910 912-914 
               
               
                   
                   
                   
                 918 923 936-941 946-947 
               
               
                 thyroid gland 
                 Clontech 
                 THR001 
                 1-2 18-21 27 32 38 42 46 49 51 53-56 66 72 
               
               
                   
                   
                   
                 77-78 87-88 97 115 119 124 130-131 134 136 
               
               
                   
                   
                   
                 152 163-165 172 183 188-192 202 212-213 
               
               
                   
                   
                   
                 216 221 224 229 235 241-243 252 257-258 
               
               
                   
                   
                   
                 261 263-265 267 277 279 297 301 305 308 
               
               
                   
                   
                   
                 311 316-325 327 357 363 373 376-377 381 
               
               
                   
                   
                   
                 383 389 397 400-401 410 413-414 427-428 
               
               
                   
                   
                   
                 443-444 446-447 457 459 463 467-469 475 
               
               
                   
                   
                   
                 482 489 495 499-500 504 509 513 519-522 
               
               
                   
                   
                   
                 526 529 533 537-538 542 545-546 548 556 
               
               
                   
                   
                   
                 564 567-568 582-583 589 592 599 605 608 
               
               
                   
                   
                   
                 611 621 623 630 642-644 648 651-652 654- 
               
               
                   
                   
                   
                 655 664 672-676 684-686 691-694 700 706- 
               
               
                   
                   
                   
                 708 713 717-718 721-722 725 729 731 734- 
               
               
                   
                   
                   
                 735 740 748 753-754 760 764 766 771 774 
               
               
                   
                   
                   
                 777 781 792 797-800 802 805 826 828-829 
               
               
                   
                   
                   
                 834 842 850 861 863 868 876 879 897 899 
               
               
                   
                   
                   
                 901 910 913 929 937 939-941 
               
               
                 trachea 
                 Clontech 
                 TRC001 
                 20-21 38 112 161 163 188 263 267 327 413 
               
               
                   
                   
                   
                 420 457 459-460 471 514 540-541 552 572 
               
               
                   
                   
                   
                 574 622 639 654-655 676-677 691-692 707 
               
               
                   
                   
                   
                 725 743 748 765 777-778 862 868 897 905 
               
               
                   
                   
                   
                 908 944 
               
               
                 uterus 
                 Clontech 
                 UTR001 
                 51 67 126 130 133 140 188-192 229 267 329 
               
               
                   
                   
                   
                 373 440 491 514 599 685-686 693 713 716- 
               
               
                   
                   
                   
                 717 735 897 905 911 939-941 
               
               
                   
               
               
                 *The 16 tissue-mRNAs and their vendor source, are as follows: 1) Normal adult brain mRNA (Invitrogen), 2) normal adult kidney mRNA (Invitrogen), 3) normal adult liver mRNA (Invitrogen), 4) normal fetal brain mRNA (Invitrogen), 5) normal fetal kidney mRNA (Invitrogen), 6) normal fetal liver mRNA (Invitrogen), 7) normal fetal skin mRNA (Invitrogen), 8) human adrenal gland mRNA (Clontech), 9) human bone marrow mRNA (Clontech), 10)  
               
               
                 # human leukemia lymphablastic mRNA (Clontech), 11) human thymus mRNA (Clontech), 12) human lymph node mRNA (Clontech), 13) human spinal cord mRNA (Clontech), 14) human thyroid mRNA (Clontech), 15) human esophagus mRNA (BioChain), 16) human conceptional umbilical cord mRNA (BioChain).  
               
             
          
         
       
     
     
       
         
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
               
                   
                   
                   
                 SMITH- 
                   
               
               
                 SEQ 
                 ACCESSION 
                   
                 WATERMAN 
                 % 
               
               
                 ID NO: 
                 NUMBER 
                 DESCRIPTION 
                 SCORE 
                 IDENTITY 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 1 
                 Z99162 
                   Schizosaccharomyces pombe  putative transporter 
                 134 
                 30 
               
               
                 2 
                 U44839 
                   Homo sapiens  UHX1 protein 
                 3719 
                 100 
               
               
                 3 
                 AF031939 
                   Mus musculus  RalBP1-associated EH domain protein Reps1 
                 3687 
                 94 
               
               
                 4 
                 AF031939 
                   Mus musculus  RalBP1-associated EH domain protein Reps1 
                 1887 
                 57 
               
               
                 5 
                 U69490 
                   Mus musculus  p56lck-associated adapter protein Lad 
                 173 
                 37 
               
               
                 6 
                 U69490 
                   Mus musculus  p56lck-associated adapter protein Lad 
                 173 
                 37 
               
               
                 7 
                 AL161538 
                   Arabidopsis thaliana  disease resistance N like protein 
                 398 
                 33 
               
               
                 8 
                 W88660 
                 Secreted protein encoded by gene 127 clone HSUBW09. 
                 175 
                 97 
               
               
                 9 
                 D50617 
                   Saccharomyces cerevisiae  YFL025C 
                 306 
                 34 
               
               
                 10 
                 AB028070 
                   Homo sapiens  activator of S phase Kinase 
                 193 
                 42 
               
               
                 11 
                 Y27676 
                 Human secreted protein encoded by gene No. 110. 
                 474 
                 100 
               
               
                 12 
                 Y30721 
                 Amino acid sequence of a human secreted protein. 
                 355 
                 98 
               
               
                 13 
                 AF257330 
                   Homo sapiens  COBW-like protein 
                 566 
                 97 
               
               
                 14 
                 AF089812 
                   Mus musculus  ubiquitin-conjugating enzyme HR6A 
                 378 
                 98 
               
               
                 15 
                 AF089812 
                   Mus musculus  ubiquitin-conjugating enzyme HR6A 
                 688 
                 90 
               
               
                 16 
                 Y94959 
                 Human secreted protein clone mc300_1 protein sequence SEO ID NO: 124. 
                 204 
                 97 
               
               
                 17 
                 AF212247 
                   Homo sapiens  CDA08 
                 2664 
                 92 
               
               
                 18 
                 AF064868 
                   Rattus norvegicus  brain-enriched guanylate kinase-associated 
                 452 
                 45 
               
               
                   
                   
                 protein 1; BEGA1 
               
               
                 19 
                 W67863 
                 Human secreted protein encoded by gene 57 clone HFEBF41. 
                 551 
                 98 
               
               
                 20 
                 AL132954 
                   Arabidopsis thaliana  putative protein 
                 201 
                 25 
               
               
                 21 
                 AL132954 
                   Arabidopsis thaliana  putative protein 
                 361 
                 34 
               
               
                 22 
                 Y48359 
                 Human prostate cancer-associated protein 56. 
                 403 
                 98 
               
               
                 23 
                 AF202892 
                   Mus musculus  Kif21a 
                 5679 
                 92 
               
               
                 24 
                 W75143 
                 Human secreted protein encoded by gene 23 clone HBMCT32. 
                 148 
                 100 
               
               
                 25 
                 Y35921 
                 Extended human secreted protein sequence, SEQ ID NO. 170. 
                 548 
                 99 
               
               
                 26 
                 Y27587 
                 Human secreted protein encoded by gene No. 21. 
                 448 
                 100 
               
               
                 27 
                 AF190900 
                   Homo sapiens  kelch-like protein C3IP1 
                 1767 
                 74 
               
               
                 28 
                 X12517 
                   Homo sapiens  C protein (AA 1-159) 
                 903 
                 99 
               
               
                 29 
                 AY014403 
                   Homo sapiens  kinesin-like protein RBKIN1 
                 9290 
                 99 
               
               
                 30 
                 AF240783 
                   Mus musculus  ELKL motif kinase 2 short form 
                 194 
                 48 
               
               
                 31 
                 Y02661 
                 Human secreted protein encoded by gene 12 clone HFTCU19. 
                 858 
                 81 
               
               
                 32 
                 AF271070 
                   Homo sapiens  amino acid transporter system A1 
                 2466 
                 100 
               
               
                 33 
                 W75151 
                 Human secreted protein encoded by gene 34 clone HTEGA81. 
                 507 
                 100 
               
               
                 34 
                 AF206329 
                   Mus musculus  polydom protein 
                 3886 
                 81 
               
               
                 35 
                 AF162224 
                   Mus musculus  angiopoietin-related protein 3 
                 138 
                 23 
               
               
                 36 
                 Y35996 
                 Extended human secreted protein sequence, SEQ ID NO. 361. 
                 503 
                 97 
               
               
                 37 
                 AF022891 
                   Drosophila melanogaster  Fuzzy 
                 248 
                 30 
               
               
                 38 
                 X76775 
                   Homo sapiens  HLA-DMA 
                 1091 
                 100 
               
               
                 39 
                 Y16045 
                   Arabidopsis thaliana  leucine-rich repeat protein 
                 160 
                 33 
               
               
                 40 
                 AC003077 
                   Homo sapiens  60% similar to AB002297 (PID:g2224539) 
                 2629 
                 61 
               
               
                 41 
                 W74887 
                 Human secreted protein encoded by gene 160 clone HCELB21. 
                 203 
                 100 
               
               
                 42 
                 AC005390 
                   Homo sapiens  R31180_1 
                 1550 
                 66 
               
               
                 43 
                 M98450 
                   Oryctolagus cuniculus  casein kinase-II beta 
                 668 
                 100 
               
               
                 44 
                 Y10840 
                 Amino acid sequence of a human secreted protein. 
                 349 
                 100 
               
               
                 45 
                 AL050231 
                   Drosophila melanogaster  alternatively spliced form 
                 203 
                 46 
               
               
                 46 
                 U58280 
                   Mus musculus  second largest subunit of RNA polymerase I 
                 4956 
                 89 
               
               
                 47 
                 AJ224819 
                   Homo sapiens  tumor suppressor 
                 457 
                 42 
               
               
                 48 
                 AF205935 
                   Mus musculus  MGA protein 
                 3477 
                 77 
               
               
                 49 
                 AF095352 
                   Homo sapiens  RAB-like protein 2B 
                 718 
                 99 
               
               
                 50 
                 L20321 
                   Homo sapiens  protein serine/threonine kinase 
                 394 
                 41 
               
               
                 51 
                 Y13374 
                   Homo sapiens  putative prenylated protein 
                 397 
                 87 
               
               
                 52 
                 AJ302031 
                   Rattus norvegicus  putative alpha 1B-glycoprotein 
                 519 
                 40 
               
               
                 53 
                 AF145681 
                   Drosophila melanogaster  BcDNA.LD23181 
                 828 
                 47 
               
               
                 54 
                 AJ132192 
                   Mus musculus  HS1 binding protein 3 
                 1454 
                 75 
               
               
                 55 
                 AF145681 
                   Drosophila melanogaster  BcDNA.LD23181 
                 692 
                 53 
               
               
                 56 
                 AB036800 
                   Drosophila melanogaster  egg-derived tyrosine phosphatase 
                 828 
                 47 
               
               
                 57 
                 Y87327 
                 Human signal peptide containing protein HSPP-104 SEQ ID NO: 104. 
                 584 
                 100 
               
               
                 58 
                 Y36237 
                 Human secreted protein encoded by gene 14. 
                 177 
                 100 
               
               
                 59 
                 Y87310 
                 Human signal peptide containing protein HSPP-87 SEQ ID NO: 87. 
                 370 
                 100 
               
               
                 60 
                 AF062476 
                   Mus musculus  retinoic acid-responsive protein; STRA6 
                 1437 
                 74 
               
               
                 61 
                 Y38394 
                 Human secreted protein encoded by gene No. 9. 
                 213 
                 100 
               
               
                 62 
                 AL139421 
                   Homo sapiens  dJ717I23.1 
                 3267 
                 100 
               
               
                   
                   
                 (novel protein similar to  Xenopus laevis  Sojo protein) 
               
               
                 63 
                 AL359782 
                   Trypanosoma brucei  possible (hhv-6) u1102, variant a dna, 
                 142 
                 50 
               
               
                   
                   
                 complete virion genome. 
               
               
                 64 
                 Y19561 
                 Amino acid sequence of a human secreted protein. 
                 514 
                 100 
               
               
                 65 
                 L12690 
                   Homo sapiens  neutrophil peptide-1 
                 493 
                 100 
               
               
                 66 
                 AF274057 
                   Rattus norvegicus  GRIP-asaociated protein 1 long form 
                 3814 
                 92 
               
               
                 67 
                 AL162458 
                   Homo sapiens  bA465L10.2 
                 6467 
                 99 
               
               
                   
                   
                 (novel C2H2 type zinc finger protein similar to chicken FZF-1) 
               
               
                 68 
                 Y87100 
                 Human secreted protein sequence SEQ ID NO: 139. 
                 267 
                 100 
               
               
                 69 
                 Y86320 
                 Human secreted protein HPRBC80, SEQ ID NO: 235. 
                 361 
                 100 
               
               
                 70 
                 Z99162 
                   Schizosaccharomyces pombe  putative transporter 
                 169 
                 27 
               
               
                 71 
                 S67057 
                   Cricetulus migratorius  = Armenian hamsters, Peptide, 
                 158 
                 71 
               
               
                   
                   
                 223 aa serum amyloid P, SAP, female protein, FP = pentraxin 
               
               
                 72 
                 Y36183 
                 Human secreted protein #55. 
                 449 
                 96 
               
               
                 73 
                 U08813 
                   Oryctolagus cuniculus  597 aa protein related to Na/glucose cotransporters 
                 1231 
                 85 
               
               
                 74 
                 AB009883 
                   Nicotiana tabacum  KED 
                 202 
                 23 
               
               
                 75 
                 AX015323 
                   Homo sapiens  hFATP1 
                 3367 
                 99 
               
               
                 76 
                 AB013361 
                   Homo sapiens  DPM2 
                 153 
                 100 
               
               
                 77 
                 Y25732 
                 Human secreted protein encoded from gene 22. 
                 212 
                 100 
               
               
                 78 
                 M37033 
                   Homo sapiens  CD53 glycoprotein 
                 116 
                 95 
               
               
                 79 
                 Y36098 
                 Extended human secreted protein sequence, SEQ ID NO. 483. 
                 193 
                 100 
               
               
                 80 
                 AB021644 
                   Homo sapiens  gonadotropin inducible transcription repressor-4 
                 886 
                 60 
               
               
                 81 
                 U68267 
                   Mus musculus  myosin binding protein H 
                 1202 
                 66 
               
               
                 82 
                 Y36332 
                 Human secreted protein encoded by gene 109. 
                 268 
                 100 
               
               
                 83 
                 AF254956 
                   Homo sapiens  candidate tumor suppressor protein 
                 2030 
                 99 
               
               
                 84 
                 L12690 
                   Homo sapiens  neutrophil peptide-1 
                 493 
                 100 
               
               
                 85 
                 AF295378 
                   Homo sapiens  MAGEF1 
                 754 
                 50 
               
               
                 86 
                 AF144627 
                   Mus musculus  SLIT1 
                 283 
                 32 
               
               
                 87 
                 AF208536 
                   Homo sapiens  nucleotide binding protein; NBP 
                 1372 
                 100 
               
               
                 88 
                 Y59657 
                 Secreted protein 108-003-5-0-A8-FL. 
                 689 
                 100 
               
               
                 89 
                 Y27626 
                 Human secreted protein encoded by gene No. 60. 
                 352 
                 100 
               
               
                 90 
                 AF035268 
                   Homo sapiens  phosphatidylserine-specific phospholipase A1 
                 498 
                 41 
               
               
                 91 
                 Y12861 
                 Human 5′ EST secreted protein SEQ ID NO: 451. 
                 448 
                 100 
               
               
                 92 
                 Y53049 
                 Human secreted protein clone cj378_3 protein sequence SEQ ID NO: 104. 
                 463 
                 100 
               
               
                 93 
                 Y41354 
                 Human secreted protein encoded by gene 47 clone HUFCJ30. 
                 288 
                 100 
               
               
                 94 
                 W74777 
                 Human secreted protein encoded by gene 48 clone HFCAI74. 
                 245 
                 100 
               
               
                 95 
                 AB040610 
                   Homo sapiens  glycoprotein beta-Gal 3′-sulfotransferase 
                 388 
                 47 
               
               
                 96 
                 D32215 
                   Danio rerio  emx2 homeoprotein 
                 1242 
                 92 
               
               
                 97 
                 Y94959 
                 Human secreted protein clone mc300_1 protein sequence SEQ ID NO: 124. 
                 204 
                 97 
               
               
                 98 
                 AF024496 
                   Caenorhabditis elegans  contains similarity to  Plasmodium falciparum   
                 390 
                 30 
               
               
                   
                   
                 glycophorin-binding protein homolog 2 (GB:X69769) 
               
               
                 99 
                 A09779 
                   Homo sapiens  interferon-gamma receptor segment binding interferon-gamma 
                 600 
                 99 
               
               
                 100 
                 AE002030 
                   Deinococcus radiodurans  thermoresistant gluconokinase 
                 246 
                 52 
               
               
                 101 
                 AB052620 
                   Mus musculus  DDM36 
                 4361 
                 89 
               
               
                 102 
                 M69245 
                   Homo sapiens  pregnancy-specific beta-1-glycoprotein 
                 613 
                 70 
               
               
                 103 
                 X92841 
                   Homo sapiens  MHC class I chain-related protein A 
                 588 
                 100 
               
               
                 104 
                 AF136401 
                   Rattus norvegicus  TRP2 
                 410 
                 88 
               
               
                 105 
                 AL031709 
                   Homo sapiens  c316G12.4 
                 561 
                 93 
               
               
                   
                   
                 (novel protein similar to API1 and API2 
               
               
                   
                   
                 (apoptosis inhibitor 1 and 2 (MIHB, MIHC, IAP1, IAP2))) 
               
               
                 106 
                 Y38389 
                 Human secreted protein encoded by gene No. 4. 
                 152 
                 90 
               
               
                 107 
                 Y27582 
                 Human secreted protein encoded by gene No. 16. 
                 320 
                 100 
               
               
                 108 
                 AF130079 
                   Homo sapiens  PRO2852 
                 231 
                 60 
               
               
                 109 
                 J02818 
                   Oryctolagus cuniculus  cytochrome P-450p-2 
                 893 
                 46 
               
               
                 110 
                 Y07894 
                 Human secreted protein fragment encoded from gene 43. 
                 169 
                 48 
               
               
                 111 
                 AF119297 
                   Homo sapiens  neuroendocrine-specific protein-like protein 1 
                 240 
                 97 
               
               
                 112 
                 X56203 
                   Plasmodium falciparum  liver stage antigen 
                 254 
                 23 
               
               
                 113 
                 Y76200 
                 Human secreted protein encoded by gene 77. 
                 262 
                 100 
               
               
                 114 
                 Y36270 
                 Human secreted protein encoded by gene 47. 
                 359 
                 100 
               
               
                 115 
                 AJ133120 
                   Rattus norvegicus  Proline rich synapse associated protein 2 
                 3938 
                 93 
               
               
                 116 
                 AL031709 
                   Homo sapiens  c316G12.4 
                 299 
                 84 
               
               
                   
                   
                 (novel protein similar to API1 and API2 
               
               
                   
                   
                 (apoptosis inhibitor 1 and 2 (MIHB, MIHC, IAP1, IAP2))) 
               
               
                 117 
                 AL031709 
                   Homo sapiens  c316G12.4 
                 582 
                 100 
               
               
                   
                   
                 (novel protein similar to API1 and AP12 
               
               
                   
                   
                 (apoptosis inhibitor 1 and 2 (MIHB, MIHC, IAP1, IAP2))) 
               
               
                 118 
                 AB018542 
                   Homo sapiens  CD98 light chain 
                 1829 
                 86 
               
               
                 119 
                 AB012692 
                   Homo sapiens  CAC-1 
                 132 
                 41 
               
               
                 120 
                 AB021644 
                   Homo sapiens  gonadotropin inducible transcription repressor-4 
                 2050 
                 57 
               
               
                 121 
                 AF110776 
                   Homo sapiens  adrenal gland protein AD-003 
                 542 
                 53 
               
               
                 122 
                 AL391688 
                   Homo sapiens  bA524D16A.2.1 
                 683 
                 42 
               
               
                   
                   
                 (novel protein similar to mouse granuphilin-a) 
               
               
                 123 
                 AB042624 
                   Homo sapiens  SIRP-b2 
                 247 
                 50 
               
               
                 124 
                 AF019980 
                   Dictyostelium discoideum  ZipA 
                 280 
                 22 
               
               
                 125 
                 U58917 
                   Homo sapiens  IL-17 receptor 
                 266 
                 30 
               
               
                 126 
                 AK021852 
                   Homo sapiens  unnamed protein product 
                 884 
                 99 
               
               
                 127 
                 AY007378 
                   Homo sapiens  G-protein beta subunit-like protein 
                 1731 
                 99 
               
               
                 129 
                 AF195522 
                   Trypanosoma cruzi  B-cell mitogen precursor 
                 345 
                 39 
               
               
                 130 
                 Z81587 
                   Caenorhabditis elegans  contains similarity to Pfam domain: PF01363 
                 276 
                 42 
               
               
                   
                   
                 (FYVE zinc finger), Score = 65.2, E-value = 1.9e-17, N = 1 
               
               
                 131 
                 AF188700 
                   Homo sapiens  actin filament associated protein 
                 844 
                 43 
               
               
                 132 
                 M77678 
                   Mus musculus  NKR-P1 gene-40 protein 
                 118 
                 26 
               
               
                 133 
                 AF217226 
                   Homo sapiens  zinc finger protein ZNF286 
                 574 
                 94 
               
               
                 134 
                 L06505 
                   Homo sapiens  ribosomal protein L12 
                 841 
                 99 
               
               
                 135 
                 Y12902 
                 Human 5′ EST secreted protein SEQ ID NO: 492. 
                 134 
                 100 
               
               
                 136 
                 L11672 
                   Homo sapiens  zinc finger protein 
                 3059 
                 60 
               
               
                 137 
                 U47924 
                   Homo sapiens  B-cell receptor associated protein 
                 925 
                 100 
               
               
                 138 
                 AC006271 
                   Homo sapiens  BC319430_7 
                 163 
                 49 
               
               
                 139 
                 AE000799 
                   Methanothermobacter thermoautotrophicus  O-linked GlcNAc transferase 
                 151 
                 37 
               
               
                 141 
                 Y13037 
                 Human secreted protein encoded by 5′ EST SEQ ID NO: 51. 
                 187 
                 100 
               
               
                 142 
                 AJ3271735 
                   Homo sapiens  sprouty (Drosophila) homolog 3 
                 170 
                 32 
               
               
                 143 
                 AF228917 
                   Rattus norvegicus  small rec 
                 454 
                 56 
               
               
                 144 
                 U41552 
                   Caenorhabditis elegans  Contains similarity to Pfam domain: PF00122 
                 127 
                 50 
               
               
                   
                   
                 (E1-E2_ATPase), Score = 36.1, E-value = 8.1e-10, N = 4 
               
               
                 145 
                 AL049569 
                   Homo sapiens  dJ37C10.3 (novel ATPase) 
                 328 
                 45 
               
               
                 146 
                 AF109888 
                   Macaca mulatta  sodium-calcium exchanger circular exon 2 transcript 
                 147 
                 32 
               
               
                 147 
                 AF217227 
                   Homo sapiens  zinc finger protein ZNF287 
                 1146 
                 43 
               
               
                 148 
                 B24426 
                 Human PR01286 protein sequence SEQ ID NO: 199. 
                 466 
                 100 
               
               
                 149 
                 AB019120 
                   Rattus norvegicus  seven transmembrane receptor 
                 1015 
                 37 
               
               
                 150 
                 AF062476 
                   Mus musculus  retinoic acid-responsive protein; STRA6 
                 190 
                 72 
               
               
                 151 
                 X64223 
                   Mus musculus  Fc-E receptor II (Fc-ERII/CD23) 
                 138 
                 34 
               
               
                 152 
                 X83543 
                   Homo sapiens  APXL 
                 412 
                 41 
               
               
                 153 
                 AF217289 
                   Homo sapiens  cadherin 20 
                 4170 
                 99 
               
               
                 154 
                 Y36310 
                 Human secreted protein encoded by gene 87. 
                 250 
                 100 
               
               
                 155 
                 D50577 
                   Mesocricetus auratus  carboxylesterase precursor 
                 441 
                 50 
               
               
                 156 
                 AB027004 
                   Homo sapiens  protein phosphatase 
                 229 
                 41 
               
               
                 157 
                 AF305071 
                   Mus musculus  calsenilin-like protein 
                 1281 
                 99 
               
               
                 158 
                 Y13126 
                 Human secreted protein encoded by 5′ EST SEQ ID NO: 140. 
                 160 
                 96 
               
               
                 159 
                 AB016215 
                   Cyprinus carpio  complement C3-Q2 
                 132 
                 35 
               
               
                 160 
                 AF294278 
                   Homo sapiens  PR-domain-containing protein 16 
                 6646 
                 99 
               
               
                 161 
                 AF305210 
                   Homo sapiens  concentrative Na+− nucleoside cotransporter hCNT3 
                 3609 
                 100 
               
               
                 163 
                 U10281 
                   Sus scrofa  gastric mucin 
                 165 
                 22 
               
               
                 164 
                 M13095 
                 Rattus sp. 0-44 protein 
                 661 
                 98 
               
               
                 165 
                 AY008763 
                   Homo sapiens  sentrin/SUMO-specific protease 
                 537 
                 53 
               
               
                 166 
                 S72304 
                 Mus ap. LMW G-protein 
                 763 
                 94 
               
               
                 167 
                 AF238315 
                   Homo sapiens  HZFw1 protein 
                 2251 
                 99 
               
               
                 168 
                 M22414 
                   Homo sapiens  ribonuclease inhibitor precursor 
                 222 
                 30 
               
               
                 169 
                 AL035702 
                   Homo sapiens  dJ593C16.1 
                 3010 
                 58 
               
               
                   
                   
                 (ras GTPase activating protein) 
               
               
                 170 
                 AL110500 
                   Caenorhabditis elegans  Y87G2A.13 
                 146 
                 22 
               
               
                 171 
                 AB028860 
                   Mus musculus  mDj10 
                 189 
                 37 
               
               
                 172 
                 M83653 
                   Homo sapiens  cytoplasmic phosphotyrosyl protein phosphatase 
                 648 
                 100 
               
               
                 173 
                 AB041601 
                   Mus musculus  unnamed protein product 
                 255 
                 61 
               
               
                 174 
                 M35012 
                   Drosophila melanogaster  non-muscle myosin heavy chain 
                 200 
                 24 
               
               
                 175 
                 D88577 
                   Mus musculus  Kupffer cell receptor 
                 904 
                 46 
               
               
                 176 
                 Y30847 
                 Human secreted protein encoded from gene 37. 
                 239 
                 100 
               
               
                 177 
                 Y01390 
                 Secreted protein encoded by gene 8 clone HTXDJ88. 
                 301 
                 100 
               
               
                 178 
                 M23725 
                   Homo sapiens  M2-type pyruvate kinase 
                 152 
                 78 
               
               
                 179 
                 X72875 
                   Homo sapiens  complement factor B 
                 3527 
                 100 
               
               
                 180 
                 Y08420 
                   Homo sapiens  nicotinic acetylcholine receptor alpha7 subunit precursor 
                 1794 
                 100 
               
               
                 181 
                 M24766 
                   Homo sapiens  alpha-2 type IV collagen 
                 3756 
                 99 
               
               
                 183 
                 AL110500 
                   Caenorhabditis elegans  Y87G2A.13 
                 180 
                 25 
               
               
                 184 
                 AF286598 
                   Homo sapiens  angiostatin binding protein 1 
                 1447 
                 62 
               
               
                 185 
                 Y13084 
                 Human secreted protein encoded by 5′ EST SEQ ID NO: 98. 
                 130 
                 62 
               
               
                 186 
                 AF151067 
                   Homo sapiens  HSPC233 
                 892 
                 58 
               
               
                 187 
                 AL133283 
                   Homo sapiens  bA31M2.1 
                 1629 
                 100 
               
               
                   
                   
                 (novel protein similar to the GLI family of zinc finger proteins) 
               
               
                 188 
                 J03799 
                   Homo sapiens  laminin-binding protein 
                 1331 
                 94 
               
               
                 189 
                 M27132 
                   Homo sapiens  ATP synthase beta subunit precursor 
                 734 
                 98 
               
               
                 190 
                 M27132 
                   Homo sapiens  ATP synthase beta subunit precursor 
                 206 
                 100 
               
               
                 191 
                 M27132 
                   Homo sapiens  ATP synthase beta subunit precursor 
                 709 
                 98 
               
               
                 192 
                 M27132 
                   Homo sapiens  ATP synthase beta subunit precursor 
                 1127 
                 89 
               
               
                 193 
                 U76638 
                   Homo sapiens  BRCA1-associated RING domain protein 
                 4101 
                 100 
               
               
                 194 
                 U76638 
                   Homo sapiens  BRCA1-associated RING domain protein 
                 394 
                 100 
               
               
                 195 
                 S57688 
                   Thermotoga maritima  EF-G 
                 289 
                 75 
               
               
                 196 
                 U09453 
                   Cricetulus griseus  UDP-N-acetylglucosamine: 
                 239 
                 85 
               
               
                   
                   
                 dolichyl phosphate N-acetylglucosamine 1-phosphate transferase 
               
               
                 197 
                 D86821 
                   Streptomyces coelicolor  PrfB 
                 151 
                 40 
               
               
                 198 
                 Y36068 
                 Extended human secreted protein sequence, SEQ ID NO. 453. 
                 495 
                 94 
               
               
                 199 
                 U38980 
                   Homo sapiens  hPMSR6 
                 408 
                 92 
               
               
                 200 
                 Y08999 
                   Homo sapiens  Sop2p-like protein 
                 572 
                 99 
               
               
                 201 
                 AJ401272 
                   Canis familiaris  Band4.1-like5 protein 
                 2233 
                 95 
               
               
                 202 
                 U09608 
                   Homo sapiens  cell surface protein 
                 292 
                 84 
               
               
                 203 
                 Y64747 
                 Human 5′ EST related polypeptide SEQ ID NO: 908. 
                 471 
                 96 
               
               
                 204 
                 Y66754 
                 Membrane-bound protein PR01187. 
                 656 
                 100 
               
               
                 205 
                 U52111 
                   Homo sapiens  Ca2+/Calmodulin-dependent protein kinase I 
                 1680 
                 99 
               
               
                 206 
                 AF279265 
                   Homo sapiens  putative anion transporter 1 
                 186 
                 39 
               
               
                 207 
                 X91911 
                   Homo sapiens  rtvp-1 
                 446 
                 40 
               
               
                 208 
                 X56390 
                   Canis familiaris  rac2 
                 508 
                 100 
               
               
                 209 
                 AK026888 
                   Homo sapiens  unnamed protein product 
                 1536 
                 100 
               
               
                 210 
                 AK026888 
                   Homo sapiens  unnamed protein product 
                 927 
                 98 
               
               
                 211 
                 AB044805 
                   Homo sapiens  6-phosphofructo-2-kinase heart isoform 
                 2452 
                 100 
               
               
                 212 
                 AB013897 
                   Homo sapiens  HKR1 
                 3083 
                 99 
               
               
                 213 
                 U37351 
                   Mus musculus  Paneth cell enhanced expression PCEE 
                 746 
                 89 
               
               
                 214 
                 AJ278475 
                   Homo sapiens  transport-secretion protein 2.1 (TTS-2.1) 
                 2179 
                 98 
               
               
                 215 
                 U58749 
                   Caenorhabditis elegans  coded for by  C. elegans  cDNA yk8c7.5; 
                 844 
                 63 
               
               
                   
                   
                 coded for by  C. elegans  cDNA yk47c5.5; 
               
               
                   
                   
                 coded for by  C. elegans  cDNA yk76b5.5; 
               
               
                   
                   
                 coded for by  C. elegans  CDNA yk8c7.3; 
               
               
                   
                   
                 coded for by  C. elegans  CDNA yk47c5.3; 
               
               
                   
                   
                 strong similarity to catalytic domains of ser/thr protein kinases 
               
               
                 216 
                 AF000195 
                   Caenorhabditis elegans  Contains similarity to Pfam domain: 
                 1072 
                 47 
               
               
                   
                   
                 PF00169 (PH), Score = 20.6, E-value = 1.9e-05, N = 1 
               
               
                 217 
                 AB016768 
                   Mus musculus  thrombospondin type 1 domain 
                 189 
                 40 
               
               
                 218 
                 AB026256 
                   Homo sapiens  organic anion transporter OATP-B 
                 1928 
                 99 
               
               
                 219 
                 X56692 
                   Homo sapiens  C-reactive protein 
                 327 
                 100 
               
               
                 220 
                 AF064801 
                   Homo sapiens  multiple membrane spanning receptor TRC8 
                 603 
                 29 
               
               
                 221 
                 AF191545 
                   Homo sapiens  aminopeptidase 
                 5048 
                 99 
               
               
                 222 
                 X66171 
                   Homo sapiens  CMRF-35 antigen 
                 228 
                 33 
               
               
                 223 
                 Z38061 
                   Saccharomyces cerevisiae  mal5, stal, len: 1367, CAI: 0.3, 
                 241 
                 22 
               
               
                   
                   
                 AMYH_YEAST P08640 GLUCOAMYLASE S1 (EC 3.2.1.3) 
               
               
                 224 
                 AC005306 
                   Homo sapiens  R27216_1 
                 1560 
                 100 
               
               
                 225 
                 AF176532 
                   Mus musculus  F-box protein FBX17 
                 1059 
                 81 
               
               
                 226 
                 AF097432 
                   Homo sapiens  GROS1-L protein 
                 2147 
                 99 
               
               
                 227 
                 AF097432 
                   Homo sapiens  GROS1-L protein 
                 1900 
                 96 
               
               
                 226 
                 AF097432 
                   Homo sapiens  GROS1-L protein 
                 3881 
                 99 
               
               
                 229 
                 Z29094 
                   Caenorhabditis elegans  contains similarity to Pfam domain: 
                 388 
                 32 
               
               
                   
                   
                 PF01699 (Sodium/calcium exchanger protein), 
               
               
                   
                   
                 Score = 268.7, E-value = 2.5e-77, N = 2 
               
               
                 230 
                 Y66669 
                 Membrane-bound protein PRO839. 
                 366 
                 100 
               
               
                 231 
                 X75931 
                   Bos taurus  Cleavage and Polyadenylation 
                 4033 
                 98 
               
               
                   
                   
                 specificity factor (CPSF) 100 kD subunit 
               
               
                 232 
                 AF152562 
                   Homo sapiens  angiopoietin-related protein 3 
                 1210 
                 99 
               
               
                 233 
                 L19686 
                   Homo sapiens  macrophage migration inhibitory factor 
                 564 
                 94 
               
               
                 234 
                 AL008723 
                   Homo sapiens  dj90G24.4 (SAAT1 
                 3408 
                 100 
               
               
                   
                   
                 (low affinity sodium glucose cotransporter 
               
               
                   
                   
                 (sodium:solute symporter family))) 
               
               
                 235 
                 U50927 
                   Rattus norvegicus  zinc transporter ZnT-2 
                 1040 
                 85 
               
               
                 236 
                 AF099973 
                   Mus musculus  schlafen2 
                 982 
                 53 
               
               
                 237 
                 U67557 
                   Methanococcus jannaschii  cell division control protein 48 (cdc48), 
                 1050 
                 41 
               
               
                   
                   
                 AAA family 
               
               
                 238 
                 AF207661 
                   Homo sapiens  sodium bicarbonate cotransporter-like protein 
                 5645 
                 100 
               
               
                 239 
                 AF284337 
                   Homo sapiens  SEBOX 
                 1209 
                 100 
               
               
                 240 
                 AF081669 
                 synthetic construct VU91B calmodulin 
                 109 
                 42 
               
               
                 241 
                 U96166 
                   Streptococcus cristatus  srpA 
                 286 
                 18 
               
               
                 242 
                 AE005024 
                 Halobacterium sp. NRC-1 Vng0821c 
                 130 
                 37 
               
               
                 243 
                 AK023335 
                   Homo sapiens  unnamed protein product 
                 2344 
                 99 
               
               
                 244 
                 AK024464 
                   Homo sapiens  FLJ00057 protein 
                 3033 
                 99 
               
               
                 245 
                 U55376 
                   Caenorhabditis elegans  coded for by  C. elegans  CDNA cm21e6; 
                 752 
                 40 
               
               
                   
                   
                 coded for by  C. elegans  CDNA cm01e2; 
               
               
                   
                   
                 similar to melibiose carrier protein (thiomethylgalactoeide permease II) 
               
               
                 246 
                 AK022660 
                   Homo sapiens  unnamed protein product 
                 1173 
                 99 
               
               
                 247 
                 D16235 
                   Bos taurus  PLC alpha 
                 156 
                 24 
               
               
                 248 
                 B08894 
                 Human secreted protein sequence encoded by gene 4 SEQ ID NO: 51. 
                 235 
                 67 
               
               
                 249 
                 AJ289709 
                 HERV-H/env62 envelope protein 
                 754 
                 39 
               
               
                 250 
                 AJ242540 
                   Volvox carteri f. nagariensis  hydroxyproline-rich glycoprotein DZ-HRGP 
                 209 
                 63 
               
               
                 251 
                 Y66747 
                 Membrane-bound protein PRO1158. 
                 609 
                 100 
               
               
                 252 
                 AL031532 
                   Schizosaccharomyces pombe  ubiquitin conjugating enzyme 
                 236 
                 41 
               
               
                 253 
                 W74899 
                 Human secreted protein encoded by gene 172 clone HODCW06. 
                 197 
                 100 
               
               
                 254 
                 D43633 
                   Oryzias latipes  G protein-coupled seven-transmembrane receptor 
                 462 
                 36 
               
               
                 255 
                 D43633 
                   Oryzias latipes  G protein-coupled seven-transmembrane receptor 
                 823 
                 42 
               
               
                 256 
                 AJ277750 
                   Homo sapiens  UBASH3A protein 
                 1035 
                 44 
               
               
                 257 
                 Y12711 
                   Homo sapiens  putative progesterone binding protein 
                 187 
                 42 
               
               
                 258 
                 W74939 
                 Human secreted protein encoded by gene 49 clone HAGBI17. 
                 211 
                 100 
               
               
                 259 
                 D16432 
                   Mus musculus  murine homologue of CD63/ME491 
                 504 
                 99 
               
               
                 260 
                 AB031051 
                   Homo sapiens  organic anion transporter OATP-E 
                 863 
                 37 
               
               
                 261 
                 J03998 
                   Plasmodium falciparum  glutamic acid-rich protein 
                 139 
                 29 
               
               
                 262 
                 U80953 
                   Caenorhabditis elegans  weakly similar in serine repeat region to rat 
                 336 
                 32 
               
               
                   
                   
                 thyroxine-binding globulin (PIR:A39567) 
               
               
                   
                   
                 and to  D. melanogaster  ecdysone-inducible protein E75-C 
               
               
                   
                   
                 (SP:E75C_DROME, P13055) 
               
               
                 263 
                 AF155662 
                   Homo sapiens  putative 16.7 kDa protein 
                 766 
                 99 
               
               
                 264 
                 Z46237 
                   Saccharomyces cerevisiae  putative protein 
                 245 
                 27 
               
               
                 265 
                 Z46237 
                   Saccharomyces cerevisiae  putative protein 
                 245 
                 27 
               
               
                 266 
                 AF208795 
                   Ictalurus punctatus  NCC receptor protein 1 
                 286 
                 50 
               
               
                 267 
                 AJ249901 
                   Mus musculus  secreted modular calcium-binding protein 2 
                 2332 
                 95 
               
               
                 268 
                 X05908 
                   Homo sapiens  lipocortin (AA 1-346) 
                 967 
                 100 
               
               
                 269 
                 X05908 
                   Homo sapiens  lipocortin (AA 1-346) 
                 1511 
                 100 
               
               
                 270 
                 X05908 
                   Homo sapiens  lipocortin (AA 1-346) 
                 967 
                 100 
               
               
                 271 
                 AC003038 
                   Homo sapiens  R30923_1 
                 2992 
                 100 
               
               
                 273 
                 U37143 
                   Homo sapiens  cytochrome P450 monooxygenase CYP2J2 
                 942 
                 44 
               
               
                 274 
                 U37143 
                   Homo sapiens  cytochrome P450 monooxygenase CYP2J2 
                 555 
                 45 
               
               
                 275 
                 AF154933 
                   Sus scrofa  complement component C3 
                 374 
                 39 
               
               
                 276 
                 Z54342 
                   Caenorhabditis elegans  contains similarity to Pfam domain: 
                 570 
                 39 
               
               
                   
                   
                 PF00328 (Histidine acid pliosphatase), Score = 511.8, 
               
               
                   
                   
                 E-value = 2e-152, N = 1 
               
               
                 277 
                 M20259 
                   Homo sapiens  thymosin beta-10 
                 169 
                 97 
               
               
                 278 
                 Y91386 
                 Human secreted protein sequence encoded by gene 41 SEQ ID NO: 107. 
                 558 
                 100 
               
               
                 279 
                 AF151110 
                   Mus musculus  COP1 protein 
                 2268 
                 99 
               
               
                 280 
                 AF117959 
                   Homo sapiens  CDK4-binding protein p34SEI1 
                 114 
                 68 
               
               
                 281 
                 Y91370 
                 Human secreted protein sequence encoded by gene 25 SEQ ID NO: 91. 
                 293 
                 100 
               
               
                 282 
                 AF079446 
                   Dictyostelium discoideum  developmental protein DG1067 
                 520 
                 38 
               
               
                 283 
                 M60618 
                   Homo sapiens  nuclear autoantigen 
                 300 
                 84 
               
               
                 284 
                 D83777 
                   Homo sapiens  expressed ubiquitously with strong expression in brain 
                 912 
                 51 
               
               
                 285 
                 L77864 
                   Homo sapiens  stat-like protein 
                 290 
                 96 
               
               
                 286 
                 Y02775 
                 Human secreted protein encoded by gene 12 clone HFTCU19. 
                 288 
                 98 
               
               
                 287 
                 L21998 
                   Homo sapiens  mucin 
                 389 
                 24 
               
               
                 288 
                 AF184275 
                   Mus musculus  F-box protein FBX18 
                 4409 
                 92 
               
               
                 289 
                 AF053356 
                   Homo sapiens  leucin rich neuronal protein 
                 264 
                 37 
               
               
                 290 
                 AC016829 
                   Arabidopsis thaliana  putative O-linked GlcNAC transferase 
                 377 
                 27 
               
               
                 291 
                 Y73414 
                 Human secreted protein clone yb101_1 protein sequence SEQ ID NO: 50. 
                 472 
                 100 
               
               
                 292 
                 W88615 
                 Secreted protein encoded by gene 82 clone HNGBT31. 
                 525 
                 97 
               
               
                 293 
                 AJ278018 
                   Homo sapiens  calsyntenin-2 
                 5080 
                 100 
               
               
                 294 
                 Y41460 
                 Fragment of human secreted protein encoded by gene 42. 
                 1034 
                 100 
               
               
                 295 
                 D79995 
                   Homo sapiens  similar to pig tubulin-tyrosine ligase. 
                 415 
                 42 
               
               
                 296 
                 AF092878 
                   Homo sapiens  zinc RING finger protein SAG 
                 323 
                 92 
               
               
                 297 
                 AL137784 
                   Homo sapiens  dJ199J3.1 
                 561 
                 100 
               
               
                   
                   
                 (novel protein similar to ubiquitin carboxyl - terminal hydrolase 16 
               
               
                   
                   
                 (EC 3.1.2.15)) 
               
               
                 298 
                 Z70310 
                   Caenorhabditis elegans  contains similarity to Pfam domain: 
                 520 
                 37 
               
               
                   
                   
                 PF00013 (KH domain), Score = 42.8, E-value = 3 .7e-12, N = 1; 
               
               
                   
                   
                 PF00023 (Ank repeat), Score = 428.2, E-value = 2.4e-125, N = 19 
               
               
                 299 
                 Y48600 
                 Human breast tumour-associated protein 61. 
                 288 
                 98 
               
               
                 300 
                 AB007889 
                   Homo sapiens  KIAA0429 
                 386 
                 46 
               
               
                 301 
                 U64601 
                   Caenorhabditis elegans  Gene probably begins in the next cosmid 
                 412 
                 50 
               
               
                 302 
                 U27109 
                   Homo sapiens  prepromultimerin 
                 208 
                 24 
               
               
                 304 
                 AF278532 
                   Homo sapiens  beta-netrin 
                 3347 
                 99 
               
               
                 305 
                 X51957 
                   Homo sapiens  muscle-specific enolase 
                 555 
                 94 
               
               
                 306 
                 Y07895 
                 Human secreted protein fragment encoded from gene 44. 
                 537 
                 100 
               
               
                 307 
                 AE001045 
                   Archaeoglobus fulgidus  proliferating-cell nucleolar antigen P120, putative 
                 144 
                 41 
               
               
                 308 
                 AB033882 
                   Coturnix japonica  protein kinase C inhibitor 
                 433 
                 60 
               
               
                 309 
                 AC006284 
                   Arabidopsis thaliana  putative ankyrin 
                 198 
                 44 
               
               
                 310 
                 AF093673 
                   Cricetulus griseus  layilin 
                 576 
                 45 
               
               
                 311 
                 J02642 
                   Homo sapiens  glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) 
                 1685 
                 97 
               
               
                 312 
                 AB012692 
                   Homo sapiens  CAC-1 
                 560 
                 94 
               
               
                 313 
                 AB012692 
                   Homo sapiens  CAC-1 
                 484 
                 73 
               
               
                 314 
                 Y17571 
                   Homo sapiens  aralar2 
                 300 
                 48 
               
               
                 315 
                 X15324 
                   Homo sapiens  angiotensinogen 
                 1925 
                 97 
               
               
                 316 
                 X97321 
                   Homo sapiens  HLA-C protein 
                 1099 
                 98 
               
               
                 317 
                 M24036 
                   Homo sapiens  MHC HLA-B8 chain 
                 1033 
                 92 
               
               
                 318 
                 U04245 
                   Homo sapiens  MHC class I antigen 
                 940 
                 95 
               
               
                 319 
                 M32318 
                   Homo sapiens  HLA protein allele B57 
                 982 
                 88 
               
               
                 320 
                 U41057 
                   Homo sapiens  HLA class I A locus antigen A*68new 
                 1801 
                 93 
               
               
                 321 
                 M32321 
                   Homo sapiens  HLA protein allele A25 
                 1163 
                 96 
               
               
                 322 
                 AJ250917 
                   Homo sapiens  human leucocyte antigen B 
                 315 
                 88 
               
               
                 323 
                 D64147 
                   Homo sapiens  HLA-Cw*0602 
                 1121 
                 96 
               
               
                 324 
                 AB005048 
                   Homo sapiens  A26null allele 
                 977 
                 85 
               
               
                 325 
                 M24043 
                   Homo sapiens  MHC HLA-A1 chain 
                 1123 
                 97 
               
               
                 326 
                 AF190900 
                   Homo sapiens  kelch-like protein C3IP1 
                 2982 
                 100 
               
               
                 327 
                 AB022023 
                   Bos taurus  nonmuscle myosin heavy chain B 
                 158 
                 22 
               
               
                 328 
                 X85019 
                   Homo sapiens  UDP-GalNAC:polypeptide N-acetylgalactosaminyl 
                 1431 
                 50 
               
               
                   
                   
                 transferase 
               
               
                 329 
                 W58985 
                   Homo sapiens  adult brain clone BV141_2 encoded protein. 
                 201 
                 100 
               
               
                 330 
                 Y14455 
                 Human secreted protein encoded by gene 45 clone HCFBJ91. 
                 284 
                 100 
               
               
                 331 
                 M25757 
                   Bos taurus  GTP:AMP phosphotransferase (EC 2.7.4.10) 
                 127 
                 73 
               
               
                 332 
                 AF037402 
                   Bos taurus  butyrophilin 
                 225 
                 25 
               
               
                 333 
                 X99211 
                   Drosophila melanogaster  ubiquitin-specific protease 
                 846 
                 68 
               
               
                 334 
                 Y36160 
                 Human secreted protein #32. 
                 500 
                 100 
               
               
                 335 
                 W67869 
                 Human secreted protein encoded by gene 63 clone HHGDB72. 
                 454 
                 91 
               
               
                 336 
                 X15334 
                   Homo sapiens  creatine kinase B 
                 162 
                 71 
               
               
                 337 
                 AL109658 
                   Homo sapiens  dJ776F14.1 (ortholog of mouse P47) 
                 310 
                 50 
               
               
                 338 
                 AL109658 
                   Homo sapiens  dJ776F14.1 (ortholog of mouse P47) 
                 797 
                 55 
               
               
                 339 
                 AJ001309 
                   Homo sapiens  DnaJ protein 
                 659 
                 100 
               
               
                 340 
                 AF096870 
                   Homo sapiens  estrogen-responsive B box protein 
                 465 
                 28 
               
               
                 341 
                 L33243 
                   Homo sapiens  polycystic kidney disease 1 protein 
                 20117 
                 99 
               
               
                 342 
                 Z83850 
                   Homo sapiens  mouse NIK serine threonine protein kinase like; match: 
                 1582 
                 95 
               
               
                   
                   
                 proteins P97820 CE02384 
               
               
                 343 
                 AF201084 
                   Secale cereale  secalin precursor 
                 149 
                 29 
               
               
                 344 
                 L16685 
                   Caenorhabditis elegans  homology with breakpoint cluster region protein; 
                 549 
                 41 
               
               
                   
                   
                 putative 
               
               
                 345 
                 AL162458 
                   Homo sapiens  bA465L10.4 
                 2489 
                 94 
               
               
                   
                   
                 (matrix metalloproteinase 9 (gelatinase B, 92 kD gelatinase, 
               
               
                   
                   
                 92 kD type IV collagenase) (CLG4B)) 
               
               
                 346 
                 AX011001 
                   Homo sapiens  MMP-9 
                 2375 
                 100 
               
               
                 347 
                 X89416 
                   Homo sapiens  protein phosphatase 5 
                 451 
                 87 
               
               
                 348 
                 Y64786 
                 Human 5′ EST related polypeptide SEQ ID NO: 947. 
                 200 
                 100 
               
               
                 349 
                 AC005167 
                   Arabidopsis thaliana  putative ubiquitin-conjugating enzyme 
                 509 
                 44 
               
               
                 350 
                 AF074901 
                   Caenorhabditis elegans  hemicentin precursor 
                 1205 
                 29 
               
               
                 351 
                 U12623 
                   Rattus norvegicus  cyclic nucleotide gated cation channel 
                 2811 
                 93 
               
               
                 352 
                 AF245516 
                   Drosophila melanogaster  Ran binding protein 9 
                 140 
                 40 
               
               
                 353 
                 AF300649 
                   Homo sapiens  regulator of G-protein signaling 
                 926 
                 100 
               
               
                 354 
                 X16396 
                   Homo sapiens  precursor polypeptide (AA −29 to 315) 
                 855 
                 80 
               
               
                 355 
                 S70290 
                   Homo sapiens  glutamine synthetase, GS {EC 6.3.1.2} 
                 1787 
                 100 
               
               
                 356 
                 X59834 
                   Homo sapiens  glutamate-ammonia ligase 
                 435 
                 89 
               
               
                 357 
                 X84801 
                   Homo sapiens  ZNF165 
                 467 
                 55 
               
               
                 358 
                 AL365234 
                   Arabidopsis thaliana  putative protein 
                 224 
                 34 
               
               
                 359 
                 AJ272034 
                   Homo sapiens  putative capacitative calcium channel 
                 4470 
                 100 
               
               
                 360 
                 AJ007798 
                   Homo sapiens  stromal antigen 3, (STAG3) 
                 278 
                 74 
               
               
                 361 
                 AJ007798 
                   Homo sapiens  stromal antigen 3, (STAG3) 
                 292 
                 82 
               
               
                 362 
                 AF193807 
                   Homo sapiens  Rh type B glycoprotein 
                 2176 
                 99 
               
               
                 363 
                 AC006963 
                   Homo sapiens  similar to Kelch proteins; similar to BAA77027 
                 895 
                 37 
               
               
                   
                   
                 (PID:g4650844) 
               
               
                 364 
                 Y86297 
                 Human secreted protein HLDCE79, SEQ ID NO: 212. 
                 530 
                 100 
               
               
                 365 
                 AB039903 
                   Homo sapiens  interferon-responsive finger protein 1 long form 
                 4302 
                 99 
               
               
                 366 
                 AF143003 
                   Perca flavescens  lysyl oxidase related protein homolog 
                 410 
                 55 
               
               
                 367 
                 AF151840 
                   Homo sapiens  CGI-82 protein 
                 1166 
                 71 
               
               
                 368 
                 AB036834 
                   Drosophila melanogaster  MAP kinase phosphate 
                 188 
                 41 
               
               
                 369 
                 M30262 
                   Homo sapiens  preprocardiodilatin-atrial natriuretic factor 
                 771 
                 100 
               
               
                 370 
                 AF135253 
                   Mus musculus  fibulin-2 
                 386 
                 41 
               
               
                 371 
                 AF112361 
                   Schmidtea mediterranea  opsin 
                 109 
                 32 
               
               
                 372 
                 X89416 
                   Homo sapiens  protein phosphatase 5 
                 387 
                 100 
               
               
                 373 
                 M96256 
                   Homo sapiens  rapamycin binding protein 
                 1169 
                 100 
               
               
                 374 
                 AF121859 
                   Homo sapiens  sorting nexin 9 
                 660 
                 43 
               
               
                 375 
                 Y07566 
                   Homo sapiens  RIT (Ric-related gene expressed in many tissues) 
                 266 
                 28 
               
               
                 376 
                 AF208291 
                   Homo sapiens  protein kinase HIPK2 
                 6242 
                 99 
               
               
                 377 
                 AF170301 
                   Mus musculus  nuclear body associated kinase 1a 
                 5972 
                 97 
               
               
                 378 
                 AL133230 
                   Homo sapiens  dJ530I15.2 
                 1170 
                 99 
               
               
                   
                   
                 (novel protein similar to placental protein DIFF40) 
               
               
                 379 
                 AB001928 
                   Homo sapiens  cathepsin V 
                 656 
                 98 
               
               
                 380 
                 AB001928 
                   Homo sapiens  cathepsin V 
                 725 
                 90 
               
               
                 381 
                 Y87329 
                 Human signal peptide containing protein HSPP-106 SEQ ID NO: 106. 
                 692 
                 94 
               
               
                 382 
                 AL356276 
                   Homo sapiens  bA367J7.2.1 
                 479 
                 51 
               
               
                   
                   
                 (novel Immunoglobulin domains containing protein (isoform 1)) 
               
               
                 383 
                 AK024551 
                   Homo sapiens  unnamed protein product 
                 824 
                 100 
               
               
                 384 
                 U70851 
                   Caenorhabditis elegans  similar to  S. cerevisiae  protein transport protein 
                 612 
                 39 
               
               
                   
                   
                 SEC7 (SP:P11075) 
               
               
                 385 
                 D83348 
                   Rattus norvegicus  long type PB-cadherin 
                 3904 
                 92 
               
               
                 386 
                 AF162149 
                   Mycoplasma bovis  variable surface lipoprotein 
                 216 
                 46 
               
               
                 387 
                 U96149 
                   Mus musculus  perforatorial protein PERF 15 
                 481 
                 68 
               
               
                 388 
                 U12535 
                   Homo sapiens  epidermal growth factor receptor kinase substrate 
                 1051 
                 46 
               
               
                 389 
                 U00059 
                   Saccharomyces cerevisiae  Yhr116wp 
                 114 
                 41 
               
               
                 390 
                 U70369 
                   Mus musculus  hematopoietic-specific IL-2 deubiquitinating enzyme 
                 873 
                 47 
               
               
                 391 
                 AF247679 
                   Xenopus laevis  putative N-terminal acetyltransferase 
                 978 
                 57 
               
               
                 392 
                 AB007646 
                   Arabidopsis thaliana  UVB-resistance protein UVR8 
                 315 
                 31 
               
               
                 393 
                 AF026246 
                   Homo sapiens  HERV-E envelope glycoprotein 
                 361 
                 91 
               
               
                 394 
                 AF198489 
                   Homo sapiens  LBP-32 
                 1747 
                 57 
               
               
                 395 
                 Y91356 
                 Human secreted protein sequence encoded by gene 11 SEQ ID NO: 77. 
                 801 
                 100 
               
               
                 396 
                 Y94978 
                 Human secreted protein clone pw337_6 2nd protein sequence 
                 444 
                 100 
               
               
                   
                   
                 SEQ ID NO: 238. 
               
               
                 397 
                 AC005996 
                   Homo sapiens  similar to  Xenopus laevis  gamma-crystallin 6; 
                 818 
                 100 
               
               
                   
                   
                 similar to AF071563 (PID:g3930581) 
               
               
                 398 
                 Y76216 
                 Human secreted protein encoded by gene 93. 
                 225 
                 97 
               
               
                 399 
                 Y11447 
                 Human 5′ EST secreted protein SEQ ID No 269. 
                 210 
                 97 
               
               
                 400 
                 U12392 
                   Haematobia irritans  putative ATPase 
                 917 
                 49 
               
               
                 401 
                 U12392 
                   Haematobia irritans  putative ATPase 
                 609 
                 49 
               
               
                 402 
                 AF002109 
                   Arabidopsis thaliana  putative ABC transporter 
                 487 
                 40 
               
               
                 403 
                 AF110645 
                   Homo sapiens  candidate tumor suppressor p33 ING1 homolog 
                 860 
                 69 
               
               
                 404 
                 J03941 
                   Mus musculus  ferritin heavy chain 
                 947 
                 100 
               
               
                 405 
                 AL023513 
                   Homo sapiens  dJ268D13.1.1 
                 808 
                 46 
               
               
                   
                   
                 (seizure related gene 6 (mouse)-like (KIAA0927) 
               
               
                   
                   
                 (isoform 1)) 
               
               
                 407 
                 D87458 
                   Homo sapiens  Similar to Human estrogen-responsive finger protein, 
                 2575 
                 99 
               
               
                   
                   
                 efp (A49656) 
               
               
                 408 
                 AJ278475 
                   Homo sapiens  transport-secretion protein 2.1 (TTS-2.1) 
                 346 
                 98 
               
               
                 409 
                 AF282886 
                   Homo sapiens  heparanase-like protein HPA2b 
                 2785 
                 100 
               
               
                 410 
                 AF015454 
                   Xenopus laevis  ER1 
                 777 
                 42 
               
               
                 411 
                 AF163762 
                   Homo sapiens  zinc metalloendopeptidase 
                 5940 
                 99 
               
               
                 412 
                 Z34277 
                   Homo sapiens  mucin 
                 978 
                 95 
               
               
                 413 
                 Y76179 
                 Human secreted protein encoded by gene 56. 
                 634 
                 100 
               
               
                 414 
                 AF168362 
                   Rattus norvegicus  protein associating with small stress protein PASS1 
                 232 
                 68 
               
               
                 415 
                 AF156777 
                   Homo sapiens  ASB-1 protein 
                 486 
                 39 
               
               
                 416 
                 AK024169 
                   Homo sapiens  unnamed protein product 
                 752 
                 100 
               
               
                 417 
                 Y08625 
                 Human secreted protein BL341 4. 
                 367 
                 100 
               
               
                 418 
                 AB026803 
                   Mus musculus  synaptotagmin VI 
                 2153 
                 96 
               
               
                 419 
                 AB026803 
                   Mus musculus  synaptotagmin VI 
                 2098 
                 94 
               
               
                 420 
                 AJ278474 
                   Sus scrofa  cytochrome P450 
                 1316 
                 50 
               
               
                 421 
                 W78135 
                 Human secreted protein encoded by gene 10 clone HPNGQ80. 
                 385 
                 100 
               
               
                 422 
                 U70476 
                   Rattus norvegicus  cationic amino acid transporter-1 
                 646 
                 62 
               
               
                 423 
                 AF188634 
                   Drosophila melanogaster  F protein 
                 546 
                 55 
               
               
                 424 
                 AJ132889 
                   Mus musculus  kinesin like protein 9 
                 3618 
                 88 
               
               
                 425 
                 D86983 
                   Homo sapiens  similar to  D. melanogaster  peroxidasin (U11052) 
                 328 
                 32 
               
               
                 426 
                 AL035464 
                   Homo sapiens  dJ1043E3.1 (novel protein) 
                 945 
                 99 
               
               
                 427 
                 ALC34380 
                   Homo sapiens  dJ50O24.4 
                 1131 
                 67 
               
               
                   
                   
                 (novel protein with DHHC zinc finger domain) 
               
               
                 428 
                 AJ400877 
                   Homo sapiens  CEGP1 protein 
                 5605 
                 100 
               
               
                 429 
                 AF060570 
                   Mus musculus  rig-1 protein 
                 1545 
                 73 
               
               
                 430 
                 Y02697 
                 Human secreted protein encoded by gene 48 clone HTNBR95. 
                 165 
                 100 
               
               
                 431 
                 Y73386 
                 HTRM clone 3279329 protein sequence. 
                 529 
                 100 
               
               
                 432 
                 AF279890 
                   Homo sapiens  2P domain potassium channel TREK2 
                 2760 
                 100 
               
               
                 433 
                 AB023658 
                   Rattus norvegicus  Ca/calmodulin-dependent protein 
                 2468 
                 93 
               
               
                   
                   
                 kinase kinase alpha, CaM-kiriase kinase alpha 
               
               
                 434 
                 J05056 
                   Oryctolagus cuniculus  oxysterol-binding protein 
                 181 
                 42 
               
               
                 435 
                 Y99437 
                 Human PRO1508 (UNQ761) amino acid sequence SEQ ID NO: 336. 
                 672 
                 83 
               
               
                 436 
                 AF043179 
                   Homo sapiens  T cell receptor beta chain 
                 681 
                 73 
               
               
                 437 
                 AF151042 
                   Homo sapiens  HSPC208 
                 585 
                 79 
               
               
                 438 
                 Y87328 
                 Human signal peptide containing protein HSPP-105 SEQ ID NO: 105. 
                 681 
                 100 
               
               
                 439 
                 Y66734 
                 Membrane-bound protein PRO1097. 
                 297 
                 70 
               
               
                 440 
                 D78572 
                   Mus musculus  membrane glycoprotein 
                 262 
                 28 
               
               
                 441 
                 L20315 
                   Mus musculus  MPS1 protein 
                 2716 
                 77 
               
               
                 442 
                 Y19588 
                 Amino acid sequence of a human secreted protein. 
                 329 
                 100 
               
               
                 443 
                 AF306550 
                   Sinorhizobium meliloti  (p)ppGpp synthetase 
                 213 
                 36 
               
               
                 444 
                 M38379 
                   Arabidopsis thaliana  calmodulin-1 
                 108 
                 37 
               
               
                 445 
                 Y12512 
                 Human 5′ EST secreted protein SEQ ID NO: 543. 
                 320 
                 98 
               
               
                 446 
                 AC013482 
                   Arabidopsis thaliana  T26F17.15 
                 309 
                 37 
               
               
                 447 
                 AC013482 
                   Arabidopsis thaliana  T26F17.15 
                 289 
                 35 
               
               
                 448 
                 AL035703 
                   Homo sapiens  dJ61A9.1 (tyrosine kinase) 
                 5326 
                 99 
               
               
                 449 
                 X59720 
                   Saccharomyces cerevisiae  YCR017C, len: 953 
                 731 
                 30 
               
               
                 450 
                 AL035526 
                   Arabidopsis thaliana  extensin-like protein 
                 154 
                 33 
               
               
                 451 
                 U16282 
                   Homo sapiens  ELL 
                 147 
                 29 
               
               
                 452 
                 M80537 
                   Drosophila melanogaster  fat protein 
                 207 
                 28 
               
               
                 453 
                 AB029334 
                   Halocynthia roretzi  HrPET-1 
                 687 
                 38 
               
               
                 454 
                 AL031349 
                   Schizosaccharomyces pombe  putative vesicular transport protein 
                 643 
                 28 
               
               
                 455 
                 AB041533 
                   Homo sapiens  sperm antigen 
                 3737 
                 98 
               
               
                 456 
                 U27109 
                   Homo sapiens  prepromultimerin 
                 208 
                 24 
               
               
                 457 
                 AJ010949 
                   Mus musculus  calcium channel alpha-2-delta-C subunit 
                 225 
                 22 
               
               
                 458 
                 AJ271643 
                   Homo sapiens  putative acid-sensing ion channel 
                 2893 
                 100 
               
               
                 459 
                 G02479 
                 Human secreted protein, SEQ ID NO: 6560. 
                 442 
                 100 
               
               
                 460 
                 D16111 
                   Homo sapiens  human homologue of rat phosphatidylethanolamine 
                 846 
                 98 
               
               
                   
                   
                 binding protein 
               
               
                 461 
                 AF180470 
                   Mus musculus  Kiaa0575 
                 1139 
                 57 
               
               
                 462 
                 Z54270 
                   Caenorhabditis elegans  F11C1.4 
                 183 
                 33 
               
               
                 463 
                 AB019527 
                   Homo sapiens  LDOC1 protein 
                 129 
                 31 
               
               
                 464 
                 U58105 
                   Mus musculus  Murine homolog of human ftp-3 
                 303 
                 36 
               
               
                 465 
                 AF172449 
                   Homo sapiens  opioid growth factor receptor 
                 325 
                 47 
               
               
                 466 
                 AL035106 
                   Homo sapiens  dJ998C11.1 (continues in Em:AL445192 as bA269H4.1) 
                 2438 
                 58 
               
               
                 467 
                 AC004561 
                   Arabidopsis thaliana  putative proline-rich protein 
                 256 
                 29 
               
               
                 468 
                 AF000198 
                   Caenorhabditis elegans  weak similarity to HSP90 
                 144 
                 28 
               
               
                 469 
                 X59720 
                   Saccharomyces cerevisiae  YCR016W, len: 290 
                 128 
                 26 
               
               
                 470 
                 AF027219 
                   Homo sapiens  ZNF202 beta 
                 620 
                 32 
               
               
                 471 
                 AF122924 
                   Xenopus laevis  Wnt inhibitory factor-1 
                 484 
                 44 
               
               
                 472 
                 X67704 
                   Drosophila melanogaster  sperm protein 
                 111 
                 32 
               
               
                 473 
                 AF317889 
                   Homo sapiens  NOX5 
                 3015 
                 99 
               
               
                 474 
                 L46815 
                   Mus musculus  DNA binding protein Rc 
                 6027 
                 77 
               
               
                 475 
                 AF190665 
                   Mus musculus  LMBR1 long form 
                 2391 
                 96 
               
               
                 476 
                 AF041382 
                   Drosophila melanogaster  microtubule binding protein D-CLIP-190 
                 244 
                 33 
               
               
                 477 
                 AL033545 
                   Arabidopsis thaliana  putative protein 
                 138 
                 49 
               
               
                 478 
                 Z98745 
                   Homo sapiens  dJ29K1.2 
                 1123 
                 56 
               
               
                 479 
                 AL118502 
                   Homo sapiens  bA371L19.1 (novel protein) 
                 2471 
                 100 
               
               
                 480 
                 Z94160 
                   Homo sapiens  dJ63G5.3 (putative Leucine rich protein) 
                 953 
                 100 
               
               
                 481 
                 X98263 
                   Homo sapiens  M-phase phosphoprotein 6 
                 469 
                 93 
               
               
                 482 
                 B08904 
                 Human secreted protein sequence encoded by gene 14 SEQ ID NO: 61. 
                 239 
                 100 
               
               
                 483 
                 AY007233 
                   Homo sapiens  phosphoinositol 3-phosphate binding protein-1 
                 3830 
                 99 
               
               
                 484 
                 AY007233 
                   Homo sapiens  phosphoinositol 3-phosphate binding protein-1 
                 4152 
                 99 
               
               
                 485 
                 Y94947 
                 Human secreted protein clone cw1292_8 protein sequence SEQ ID NO: 100. 
                 408 
                 100 
               
               
                 486 
                 J03614 
                   Oryctolagus cuniculus  myosin heavy chain 
                 225 
                 26 
               
               
                 487 
                 AB026256 
                   Homo sapiens  organic anion transporter OATP-B 
                 188 
                 92 
               
               
                 488 
                 AJ277748 
                   Rattus norvegicus  NTPDase6 
                 501 
                 96 
               
               
                 489 
                 U02289 
                   Caenorhabditis elegans  GTPase-activating protein 
                 551 
                 36 
               
               
                 490 
                 B08894 
                 Human secreted protein sequence encoded by gene 4 SEQ ID NO: 51. 
                 211 
                 69 
               
               
                 491 
                 AF238862 
                   Xenopus laevis  Churchill protein 
                 495 
                 71 
               
               
                 492 
                 D87076 
                   Homo sapiens  similar to human bromodomain protein BR140 (JC2069) 
                 107 
                 30 
               
               
                 493 
                 A11959 
                 synthetic construct PP4X 
                 1122 
                 99 
               
               
                 494 
                 Y87252 
                 Human signal peptide containing protein HSPP-29 SEQ ID NO: 29. 
                 391 
                 100 
               
               
                 495 
                 AF015565 
                   Dictyostelium discoideum  VacA 
                 245 
                 31 
               
               
                 496 
                 AF305427 
                   Mus musculus  cAMP-dependent protein kinase regulatory subunit 
                 940 
                 78 
               
               
                 497 
                 K02581 
                   Homo sapiens  thymidine kinase (EC 2.7.1.21) 
                 1216 
                 99 
               
               
                 498 
                 AB048364 
                   Mus musculus  osteoblast differentiation promoting factor 
                 1017 
                 46 
               
               
                 499 
                 AJ006239 
                   Homo sapiens  dihydropteridine reductase 
                 933 
                 100 
               
               
                 500 
                 Y59795 
                 Human normal ovarian tissue derived protein 72. 
                 554 
                 100 
               
               
                 501 
                 AL109965 
                   Homo sapiens  dJ1121G12.1.2 
                 537 
                 54 
               
               
                   
                   
                 (A novel protein containing a putative PHD finger domain, isoform 2) 
               
               
                 502 
                 Y12021 
                 Human 5′ EST secreted protein SEQ ID NO: 334. 
                 265 
                 97 
               
               
                 503 
                 G01878 
                 Human secreted protein, SEQ ID NO: 5959. 
                 348 
                 92 
               
               
                 504 
                 AL023777 
                   Schizosaccharomyces pombe  putative RNA-binding protein 
                 318 
                 39 
               
               
                 505 
                 M11902 
                   Mus musculus  proline-rich salivary protein 
                 109 
                 45 
               
               
                 506 
                 J01998 
                 AKV murine leukemia virus gag-pol polyprotein 
                 621 
                 42 
               
               
                   
                   
                 (tag amber codon at 2250-2252 inserts Gln in Mo-MuLV) 
               
               
                 507 
                 AC012396 
                   Arabidopsis thaliana  tumor-related protein, putative 
                 154 
                 45 
               
               
                 508 
                 X06160 
                   Homo sapiens  precursor polypeptide (AA −24 to 140) 
                 742 
                 97 
               
               
                 509 
                 Y99351 
                 Human PRO1481 (UNQ750) amino acid sequence SEQ ID NO: 41. 
                 1725 
                 100 
               
               
                 510 
                 M22760 
                   Homo sapiens  cytochrome c oxidase subunit Va 
                 461 
                 97 
               
               
                 511 
                 AF199008 
                   Mus musculus  PALS1 
                 3396 
                 96 
               
               
                 512 
                 AF145021 
                   Mus musculus  exportin 4 
                 3814 
                 98 
               
               
                 513 
                 AF119837 
                   Cyprinus carpio  hexokinase I 
                 2020 
                 75 
               
               
                 514 
                 Z69043 
                   Homo sapiens  translocon-associated protein delta subunit precursor 
                 459 
                 98 
               
               
                 515 
                 AF276512 
                   Homo sapiens  RNA polymerase II elongation factor ELL3 
                 2071 
                 99 
               
               
                 516 
                 M34379 
                   Homo sapiens  elastase/medullasin precursor (EC 3.4.21.37) 
                 1320 
                 96 
               
               
                 517 
                 Y11385 
                 Human 5′ EST secreted protein SEQ ID No 207. 
                 220 
                 100 
               
               
                 518 
                 AF045022 
                   Bos taurus  phosphatidic acid-preferring phospholipase A1 
                 4254 
                 91 
               
               
                 519 
                 U00031 
                   Caenorhabditis elegans  Contains similarity to Pfam domain: PF00957 
                 980 
                 47 
               
               
                   
                   
                 (synaptobrevin), Score = 100.3, E-value = 1.2e-26, N = 1 
               
               
                 520 
                 X92098 
                   Homo sapiens  transmembrane protein 
                 597 
                 89 
               
               
                 521 
                 X92098 
                   Homo sapiens  transmembrane protein 
                 1003 
                 96 
               
               
                 522 
                 X57346 
                   Homo sapiens  HS1 
                 1218 
                 95 
               
               
                 523 
                 AF207901 
                   Xenopus laevis  cingulin 
                 317 
                 24 
               
               
                 524 
                 AL035678 
                   Arabidopsis thaliana  putative protein 
                 246 
                 36 
               
               
                 525 
                 Y30721 
                 Amino acid sequence of a human secreted protein. 
                 231 
                 100 
               
               
                 526 
                 AL035659 
                   Homo sapiens  dJ979N1.1 (dJ979N1.1) 
                 1822 
                 47 
               
               
                 527 
                 AL035548 
                   Schizosaccharomyces pombe  putative ribose methyltransferase 
                 263 
                 38 
               
               
                 528 
                 AB015617 
                   Homo sapiens  ELKS 
                 3464 
                 72 
               
               
                 529 
                 L25665 
                   Homo sapiens  GTP-binding protein 
                 2227 
                 99 
               
               
                 530 
                 Y11794 
                 Human 5′ EST secreted protein SEQ ID No: 394. 
                 375 
                 100 
               
               
                 531 
                 Y14685 
                   Arabidopsis thaliana  polynucleotide phosphorylase 
                 1375 
                 40 
               
               
                 532 
                 X52574 
                   Mus musculus  GTP binding protein 
                 4571 
                 91 
               
               
                 533 
                 AB040119 
                   Homo sapiens  mitochondrial import receptor Tom22 
                 718 
                 100 
               
               
                 534 
                 U23822 
                   Danio rerio  collagen II A1 
                 295 
                 43 
               
               
                 535 
                 U39621 
                   Gallus gallus  type V collagen 
                 371 
                 46 
               
               
                 536 
                 X79682 
                   Felis catus  neuronal protein 
                 617 
                 96 
               
               
                 537 
                 AF099935 
                   Homo sapiens  MDC-3.13 isoform 2 
                 532 
                 55 
               
               
                 538 
                 AF145672 
                   Drosophila melanogaster  BcDNA.GH12174 
                 230 
                 36 
               
               
                 539 
                 AL035709 
                   Arabidopsis thaliana  putative protein 
                 572 
                 37 
               
               
                 540 
                 AL022104 
                   Schizosaccharcmyces pombe  putative pre-mrna splicing factor rna helicase 
                 431 
                 31 
               
               
                 541 
                 AF113615 
                   Homo sapiens  FH1/FH2 domain-containing protein FHOS 
                 1138 
                 55 
               
               
                 542 
                 U85494 
                   Zea mays  LON1 protease 
                 1797 
                 47 
               
               
                 543 
                 X54162 
                   Homo sapiens  64 Kd autoantigen 
                 587 
                 38 
               
               
                 544 
                 AB037158 
                   Homo sapiens  DSCR6a 
                 165 
                 40 
               
               
                 545 
                 Y07754 
                 Human secreted protein fragment encoded from gene 11. 
                 1723 
                 100 
               
               
                 546 
                 AL009171 
                   Drosophila melanogaster  62D9.o 
                 184 
                 33 
               
               
                 547 
                 M18963 
                   Homo sapiens  islet regenerating protein 
                 817 
                 89 
               
               
                 548 
                 U29463 
                   Homo sapiens  cytochrome b561 
                 1125 
                 91 
               
               
                 549 
                 Z25420 
                   Gallus gallus  class II INCENP protein 
                 237 
                 26 
               
               
                 550 
                 AL031324 
                   Schizosaccharomyces pombe  membrane atpase 
                 1150 
                 41 
               
               
                 551 
                 AF145609 
                   Drosophila melanogaster  BcDNA.GH02833 
                 666 
                 41 
               
               
                 552 
                 AF302079 
                   Homo sapiens  HSP22-like protein interacting protein 17 
                 459 
                 100 
               
               
                 553 
                 AJ242730 
                   Homo sapiens  polyhomeotic 2 
                 451 
                 59 
               
               
                 554 
                 U88167 
                   Caenorhabditis elegans  contains similarity to C2 domains 
                 428 
                 45 
               
               
                 555 
                 AF156779 
                   Homo sapiens  ASB-4 protein 
                 513 
                 33 
               
               
                 556 
                 AF305081 
                   Homo sapiens  tankyrase-related protein 
                 5992 
                 98 
               
               
                 557 
                 AB028968 
                   Homo sapiens  KIAA1045 protein 
                 2090 
                 99 
               
               
                 558 
                 AB028968 
                   Homo sapiens  KIAA1045 protein 
                 1448 
                 99 
               
               
                 559 
                 AJ250998 
                   Mucor circinelloides  carotenoid regulatory protein 
                 381 
                 40 
               
               
                 560 
                 AL109804 
                   Homo sapiens  dJ1009E24.1.1 
                 6334 
                 99 
               
               
                   
                   
                 (A novel protein similar to the mouse sialoadhesin, a macrophage sialic acid 
               
               
                   
                   
                 binding receptor, isoform 1) 
               
               
                 561 
                 Y76539 
                 Human ovarian tumor EST fragment encoded protein 35. 
                 261 
                 98 
               
               
                 562 
                 L07765 
                   Homo sapiens  carboxylesterase 
                 209 
                 51 
               
               
                 563 
                 Z38061 
                   Saccharomyces cerevisiae  mal5, stal, len: 1367, CAI: 0.3, 
                 206 
                 21 
               
               
                   
                   
                 AMYH_YEAST P08640 GLUCOAMYLASE S1 (EC 3.2.1.3) 
               
               
                 564 
                 AY009133 
                   Homo sapiens  FYVE-finger-containing Rab5 effector protein Rabenosyn-5 
                 4027 
                 99 
               
               
                 565 
                 AF287478 
                   Lytechinus variegatus  embryonic blastocoelar extracellular matrix 
                 1116 
                 35 
               
               
                   
                   
                 protein precursor 
               
               
                 566 
                 AF223427 
                   Xenopus laevis  RRM-containing protein SEB-4 
                 793 
                 88 
               
               
                 567 
                 AP000693 
                   Homo sapiens  partial CDS 
                 470 
                 56 
               
               
                 568 
                 AJ131244 
                   Homo sapiens  Sec24A protein 
                 5357 
                 98 
               
               
                 569 
                 Y12049 
                 Human 5′ EST secreted protein SEQ ID NO: 362. 
                 253 
                 92 
               
               
                 570 
                 AF255342 
                   Homo sapiens  putative pheromone receptor V1RL1 long form 
                 1859 
                 99 
               
               
                 571 
                 Y99355 
                 Human PRO1295 (UNQ664) amino acid sequence SEQ ID NO: 54. 
                 1265 
                 100 
               
               
                 572 
                 ACC02397 
                   Mus musculus  C9 
                 678 
                 51 
               
               
                 573 
                 M28821 
                   Mus musculus  Tcte-1 peptide 
                 1884 
                 74 
               
               
                 574 
                 AF000196 
                   Caenorhabditis elegans  strong similarity to the SNF2/RAD54 family of 
                 185 
                 36 
               
               
                   
                   
                 helicases; partial CDS 
               
               
                 575 
                 L34587 
                   Homo sapiens  RNA polymerase II elongation factor SIII, p15 subunit 
                 426 
                 100 
               
               
                 576 
                 AL035419 
                   Homo sapiens  dJ1100H13.4 (putative RhoGAP domain containing protein) 
                 212 
                 35 
               
               
                 577 
                 D83004 
                   Homo sapiens  ubiquitin-conjugating enzyme E2 UbcH-ben 
                 385 
                 100 
               
               
                 578 
                 Y87271 
                 Human signal peptide containing protein HSPP-48 SEQ ID NO: 48. 
                 474 
                 86 
               
               
                 579 
                 U96626 
                   Mus musculus  chondroadherin 
                 341 
                 29 
               
               
                 580 
                 Z85986 
                   Homo sapiens  dJ108K11.3 
                 1468 
                 99 
               
               
                   
                   
                 (similar to yeast suppressor protein SRP40) 
               
               
                 581 
                 AF061529 
                   Mus musculus  rjs 
                 230 
                 32 
               
               
                 582 
                 AF228738 
                   Homo sapiens  profilin IIa 
                 750 
                 100 
               
               
                 583 
                 AF228738 
                   Homo sapiens  profilin IIa 
                 624 
                 87 
               
               
                 584 
                 AF181640 
                   Drosophila melanogaster  BcDNA.GH09817 
                 190 
                 47 
               
               
                 585 
                 AB037901 
                   Homo sapiens  gene amplified in squamous cell carcinoma-1 
                 1340 
                 54 
               
               
                 586 
                 AF149285 
                   Caenorhabditis elegans  Osm-3 
                 806 
                 62 
               
               
                 587 
                 AF056021 
                   Xenopus laevis  p80 katanin 
                 146 
                 31 
               
               
                 588 
                 U80931 
                   Caenorhabditis elegans  strong similarity to class-III of pyridoxal- 
                 866 
                 49 
               
               
                   
                   
                 phoshate-dependent aminotransferases 
               
               
                 589 
                 AK026962 
                   Homo sapiens  unnamed protein product 
                 1725 
                 99 
               
               
                 590 
                 AB011483 
                 
                   Arabidopsis thaliana 
                 
                 288 
                 28 
               
               
                 591 
                 AF152243 
                   Mus musculus  putative E1-E2 ATPase 
                 3942 
                 98 
               
               
                 592 
                 AJ243460 
                 Leishmania major proteophosphoglycan 
                 204 
                 25 
               
               
                 593 
                 AX021519 
                   Homo sapiens  unnamed protein product 
                 1317 
                 99 
               
               
                 594 
                 AL121581 
                   Homo sapiens  dJ1022E24.4 
                 1162 
                 69 
               
               
                   
                   
                 (A novel protein weakly similar to protein-L-isoaspartate 
               
               
                   
                   
                 o-methyltransferase (EC 2.1.1.77)) 
               
               
                 595 
                 AL031177 
                   Homo sapiens  dJ889M15.3 (novel protein) 
                 177 
                 44 
               
               
                 596 
                 AL035601 
                   Arabidopsis thaliana  putative protein 
                 301 
                 28 
               
               
                 597 
                 AF202118 
                   Homo sapiens  HOX D1 protein 
                 1726 
                 100 
               
               
                 598 
                 AC007228 
                   Homo sapiens  BC37295_1 
                 955 
                 42 
               
               
                 599 
                 Z69727 
                   Schizosaccharomyces pombe  probable ribosomal protein 
                 249 
                 34 
               
               
                 600 
                 L08134 
                   Rattus norvegicus  glycoprotein 
                 278 
                 24 
               
               
                 601 
                 AK025598 
                   Homo sapiens  unnamed protein product 
                 3738 
                 99 
               
               
                 602 
                 X89453 
                   Rattus norvegicus  DRPLA 
                 173 
                 27 
               
               
                 603 
                 AF137030 
                   Homo sapiens  transmembrane protein 2 
                 1285 
                 57 
               
               
                 604 
                 AL356014 
                   Arabidopsis thaliana  putative protein 
                 436 
                 44 
               
               
                 605 
                 G03490 
                 Human secreted protein, SEQ ID NO: 7571. 
                 450 
                 96 
               
               
                 606 
                 AY007380 
                   Homo sapiens  F-box protein FBX30 
                 1211 
                 100 
               
               
                 607 
                 D38076 
                   Homo sapiens  Ran-BP1 (Ran-binding protein 1) 
                 916 
                 100 
               
               
                 608 
                 U27837 
                   Diphyllobothrium dendriticum  actin 
                 1033 
                 50 
               
               
                 609 
                 M25750 
                   Oryctolagus cuniculus  sarcolumenin precursor 
                 2307 
                 97 
               
               
                 610 
                 AF180920 
                   Homo sapiens  cyclin L ania-6a 
                 630 
                 51 
               
               
                 611 
                 AF168990 
                   Homo sapiens  putative GTP-binding protein 
                 2742 
                 99 
               
               
                 612 
                 U77942 
                   Homo sapiens  syntaxin 7 
                 421 
                 98 
               
               
                 613 
                 U00046 
                   Caenorhabditis elegans  similar to yeast heat shock protein STI1 
                 362 
                 27 
               
               
                 614 
                 AB001928 
                   Homo sapiens  cathepsin V 
                 226 
                 100 
               
               
                 615 
                 AB016687 
                   Arabidopsis thaliana  SMC-like protein 
                 326 
                 22 
               
               
                 616 
                 AL163279 
                   Homo sapiens  homolog to cAMP response element binding and 
                 181 
                 53 
               
               
                   
                   
                 beta transducin family proteins 
               
               
                 617 
                 AF176524 
                   Mus musculus  F-box protein FBL10 
                 525 
                 50 
               
               
                 618 
                 AF070656 
                   Homo sapiens  HSPC002 
                 731 
                 86 
               
               
                 619 
                 Y00339 
                   Homo sapiens  carbonic anhydrase II (AA 1-260) 
                 910 
                 88 
               
               
                 620 
                 M29913 
                   Homo sapiens  eosinophil peroxidase 
                 3757 
                 100 
               
               
                 621 
                 AC006768 
                   Caenorhabditis elegans  contains similarity to  Mycoplasma genitalium   
                 1216 
                 54 
               
               
                   
                   
                 glycerol-3-phospate dehydrogenase (SW: P47285) 
               
               
                 622 
                 AB033595 
                   Mus musculus  gasdermin 
                 369 
                 31 
               
               
                 623 
                 AF132449 
                   Mus musculus  smoothelin small isoform S1 
                 646 
                 54 
               
               
                 624 
                 AF247039 
                 porcine adenovirus 3 163R* 
                 141 
                 31 
               
               
                 625 
                 L43065 
                   Saccharomyces cerevisiae  suppresses the respiratory deficiency of a yeast 
                 403 
                 36 
               
               
                   
                   
                 pet mutant 
               
               
                 626 
                 AF071172 
                   Homo sapiens  HERC2 
                 483 
                 35 
               
               
                 627 
                 Y40090 
                 Peptide sequence derived from a human secreted protein. 
                 921 
                 98 
               
               
                 628 
                 AP001306 
                   Arabidopsis thaliana  contains similarity to cell wall-plasma membrane 
                 717 
                 36 
               
               
                   
                   
                 linker protein-gene_id: MKA23.5 
               
               
                 629 
                 AE004543 
                   Pseudomonas aeruginosa  probable MFS transporter 
                 207 
                 32 
               
               
                 630 
                 AK025204 
                   Homo sapiens  unnamed protein product 
                 1925 
                 99 
               
               
                 631 
                 AL050321 
                   Homo sapiens  dJ717M23.1 (novel gene) 
                 2443 
                 98 
               
               
                 632 
                 AL050321 
                   Homo sapiens  dJ717M23.1 (novel gene) 
                 3988 
                 99 
               
               
                 634 
                 U87804 
                   Caulobacter crescentus  GidA 
                 396 
                 65 
               
               
                 635 
                 AF004161 
                   Oryctolagus cuniculus  peroxisomal Ca-dependent solute carrier 
                 154 
                 52 
               
               
                 636 
                 U78090 
                   Rattus norvegicus  potassium channel regulator 1 
                 682 
                 91 
               
               
                 637 
                 AC002394 
                   Homo sapiens  Gene product with similarity to dynein beta subunit 
                 536 
                 41 
               
               
                 638 
                 AL109640 
                   Homo sapiens  dJ543J19.5 (CGI-107 Protein) 
                 478 
                 98 
               
               
                 639 
                 AB017065 
                   Arabidopsis thaliana  contains similarity to small nuclear 
                 125 
                 34 
               
               
                   
                   
                 ribonucleoprotein-gene id: MFC16.18 
               
               
                 640 
                 AK024498 
                   Homo sapiens  FLJ00106 protein 
                 927 
                 99 
               
               
                 641 
                 AF187064 
                   Homo sapiens  p75NTR-associated cell death executor; NADE 
                 303 
                 57 
               
               
                 642 
                 AB017507 
                   Homo sapiens  Apg12 
                 724 
                 100 
               
               
                 643 
                 AF035632 
                   Rattus norvegicus  syntaxin 12 
                 1231 
                 90 
               
               
                 644 
                 U48852 
                   Cricetulus griseus  HT protein 
                 974 
                 57 
               
               
                 645 
                 AB015798 
                   Homo sapiens  DnaJ homolog 
                 1572 
                 93 
               
               
                 646 
                 AB031046 
                   Homo sapiens  HMG-box transcription factor TCF-3 
                 3096 
                 100 
               
               
                 647 
                 U78547 
                   Chlamydomonas reinhardtii  PF20 
                 209 
                 38 
               
               
                 648 
                 AK024452 
                   Homo sapiens  FLJ00044 protein 
                 2019 
                 63 
               
               
                 649 
                 Y13117 
                 Human secreted protein encoded by 5′ EST SEQ ID NO: 131. 
                 268 
                 100 
               
               
                 650 
                 AB023419 
                   Mus musculus  mSox7 
                 1803 
                 87 
               
               
                 651 
                 AF176688 
                   Rattus norvegicus  sodium/calcium/potassium exchanger NCKX1 
                 184 
                 34 
               
               
                 652 
                 AK026622 
                   Homo sapiens  unnamed protein product 
                 4385 
                 99 
               
               
                 653 
                 AFC16712 
                   Mus musculus  testicular condensing enzyme 
                 191 
                 36 
               
               
                 654 
                 AF135440 
                   Mus musculus  huntington yeast partner C 
                 4306 
                 94 
               
               
                 655 
                 AF135440 
                   Mus musculus  huntington yeast partner C 
                 3709 
                 86 
               
               
                 656 
                 AK022184 
                   Homo sapiens  unnamed protein product 
                 680 
                 100 
               
               
                 657 
                 U02467 
                   Lilium longiflorum  meiotin-1 
                 182 
                 33 
               
               
                 658 
                 M17099 
                   Oryctolagus cuniculus  progesterone-induced protein 
                 1832 
                 93 
               
               
                 659 
                 AF113132 
                   Homo sapiens  phosphoserine aminotransferase 
                 1673 
                 100 
               
               
                 660 
                 AF294790 
                   Mus musculus  RING-finger protein MURF 
                 137 
                 27 
               
               
                 661 
                 X56203 
                   Plasmodium falciparum  liver stage antigen 
                 157 
                 22 
               
               
                 662 
                 Y64994 
                 Human 5′ EST related polypeptide SEQ ID NO: 1155. 
                 372 
                 100 
               
               
                 663 
                 U82626 
                   Rattus norvegicus  basement membrane-associated chondroitin proteoglycan 
                 146 
                 22 
               
               
                   
                   
                 Bamacan 
               
               
                 664 
                 AF155739 
                   Mus musculus  axotrophin 
                 3007 
                 85 
               
               
                 665 
                 AB037596 
                   Mus musculus  beta-1,6-N-acetylglucosaminyltransferase B 
                 1257 
                 73 
               
               
                 666 
                 AF168132 
                   Homo sapiens  RU1 
                 2485 
                 55 
               
               
                 667 
                 AF132961 
                   Homo sapiens  CGI-27 protein 
                 1197 
                 100 
               
               
                 668 
                 AB025258 
                   Mus musculus  granuphilin-a 
                 729 
                 42 
               
               
                 669 
                 AL391688 
                   Homo sapiens  bA524D16A.2.1 
                 762 
                 43 
               
               
                   
                   
                 (novel protein similar to mouse granuphilin-a) 
               
               
                 670 
                 AP001745 
                   Homo sapiens  human cDNA DKFZp586F0422, Accession No. AL050173 
                 3747 
                 100 
               
               
                 671 
                 X58454 
                   Homo sapiens  DS dopamine receptor 
                 1024 
                 85 
               
               
                 672 
                 AB017059 
                   Arabidopsis thaliana  FH protein interacting protein FIP2 
                 212 
                 35 
               
               
                 673 
                 AF255908 
                   Streptococcus pneumoniae  PspA 
                 177 
                 29 
               
               
                 674 
                 Y02669 
                 Human secreted protein encoded by gene 20 clone HMKAH10. 
                 288 
                 100 
               
               
                 675 
                 AB024986 
                   Oryza sativa  cyclin 
                 142 
                 48 
               
               
                 676 
                 X70681 
                   Xenopus laevis  zinc finger protein 
                 144 
                 33 
               
               
                 677 
                 AL390026 
                   Homo sapiens  dJ336K20B.1 (novel protein based on FGENESH) 
                 964 
                 100 
               
               
                 678 
                 AC026815 
                   Oryza sativa  putative ATP-dependent RNA helicase (5′-partial) 
                 437 
                 43 
               
               
                 679 
                 AF196779 
                   Homo sapiens  JM10 protein 
                 1182 
                 98 
               
               
                 680 
                 U40802 
                   Caenorhabditis elegans  similar to other protein phosphatases 1, 2A and 2B 
                 325 
                 36 
               
               
                 681 
                 AJ238854 
                   Rattus norvegicus  type A/B hnRNP p40 
                 1659 
                 91 
               
               
                 682 
                 Y36083 
                 Extended human secreted protein sequence, SEQ. ID NO. 468. 
                 430 
                 98 
               
               
                 683 
                 U37283 
                   Homo sapiens  microfibril-associated glycoprotein-2 MAGP-2 
                 846 
                 94 
               
               
                 684 
                 AJ235270 
                   Rickettsia prowazekii  50S RIBOSOMAL PROTEIN L10 (rplJ) 
                 122 
                 23 
               
               
                 685 
                 W67828 
                 Human secreted protein encoded by gene 22 clone HFEAF41. 
                 510 
                 100 
               
               
                 686 
                 W67828 
                 Human secreted protein encoded by gene 22 clone HFEAF41. 
                 403 
                 85 
               
               
                 687 
                 AK026226 
                   Homo sapiens  unnamed protein product 
                 1937 
                 100 
               
               
                 688 
                 AK026226 
                   Homo sapiens  unnamed protein product 
                 578 
                 100 
               
               
                 689 
                 D26549 
                   Bos taurus  bovine adseverin 
                 3527 
                 92 
               
               
                 690 
                 AK024644 
                   Homo sapiens  unnamed protein product 
                 245 
                 67 
               
               
                 691 
                 X63546 
                   Homo sapiens  oncogene 
                 1083 
                 78 
               
               
                 692 
                 X63546 
                   Homo sapiens  oncogene 
                 1613 
                 83 
               
               
                 693 
                 AB029334 
                   Halocynthia roretzi  HrPET-1 
                 614 
                 37 
               
               
                 694 
                 AF286473 
                   Mus musculus  retinitis pigmentosa GTPase regulator 
                 181 
                 35 
               
               
                 695 
                 AB002405 
                   Homo sapiens  LAK-4p 
                 346 
                 34 
               
               
                 696 
                 Y14448 
                 Human secreted protein encoded by gene 38 clone HFGAH44. 
                 316 
                 100 
               
               
                 697 
                 AL133216 
                   Homo sapiens  bA291L22.2 
                 256 
                 100 
               
               
                   
                   
                 (similar to CDC10 (cell division cycle 10,  S. cerevisiae , homolog)) 
               
               
                 698 
                 AF065389 
                   Homo sapiens  tetraspan NET-4 
                 1111 
                 74 
               
               
                 699 
                 AF161390 
                   Homo sapiens  HSPC272 
                 281 
                 81 
               
               
                 700 
                 Z83114 
                   Caenorhabditis elegans  K09B11.2 
                 233 
                 37 
               
               
                 701 
                 Y41360 
                 Human secreted protein encoded by gene 53 clone H3PAD75. 
                 490 
                 100 
               
               
                 702 
                 Y41360 
                 Human secreted protein encoded by gene 53 clone HJPAD75. 
                 233 
                 92 
               
               
                 703 
                 AL049481 
                   Arabidopsis thaliana  putative protein 
                 829 
                 53 
               
               
                 704 
                 U67949 
                   Caenorhabditis elegans  contains similarity t to sugar and other 
                 486 
                 36 
               
               
                   
                   
                 transporters (Pfam: sugar_tr.hmm.score: 13.46) 
               
               
                 705 
                 J02883 
                   Homo sapiens  colipase precursor 
                 243 
                 100 
               
               
                 706 
                 X66286 
                   Gallus gallus  tensin 
                 1009 
                 73 
               
               
                 707 
                 G01118 
                 Human secreted protein, SEQ ID NO: 5199. 
                 360 
                 100 
               
               
                 708 
                 D50857 
                   Homo sapiens  DOCK180 protein 
                 1060 
                 51 
               
               
                 709 
                 AE003511 
                   Drosophila melanogaster  CG14194 gene product 
                 542 
                 54 
               
               
                 710 
                 L26247 
                   Homo sapiens  isolog of yeast sui1 and rice gos2; putative 
                 470 
                 86 
               
               
                 711 
                 Y12952 
                 Amino acid sequence of a human secreted peptide. 
                 362 
                 98 
               
               
                 712 
                 U41849 
                   Saccharomyces cerevisiae  Yta6p 
                 156 
                 23 
               
               
                 713 
                 AF168362 
                   Rattus norvegicus  protein associating with small stress protein PASS1 
                 220 
                 35 
               
               
                 714 
                 Y48256 
                 Human prostate cancer-associated protein 42. 
                 242 
                 75 
               
               
                 715 
                 AF053130 
                   Mus musculus  unconventional myosin MYO15 
                 579 
                 36 
               
               
                 716 
                 AF083385 
                   Homo sapiens  30 kDa splicing factor; SPF 30 
                 133 
                 40 
               
               
                 717 
                 AF182417 
                   Homo sapiens  MDS016 
                 406 
                 100 
               
               
                 718 
                 AF065389 
                   Homo sapiens  tetraspan NET-4 
                 584 
                 43 
               
               
                 719 
                 W78132 
                 Human secreted protein encoded by gene 7 clone HPEBD85. 
                 246 
                 100 
               
               
                 720 
                 AK023971 
                   Homo sapiens  unnamed protein product 
                 1358 
                 100 
               
               
                 721 
                 AF288813 
                   Mus musculus  synembryn 
                 2384 
                 86 
               
               
                 722 
                 X56203 
                   Plasmodium falciparum  liver stage antigen 
                 188 
                 19 
               
               
                 723 
                 AF190501 
                   Homo sapiens  leucine-rich repeat-containing G protein-coupled receptor 6 
                 4286 
                 99 
               
               
                 724 
                 AF022789 
                   Homo sapiens  ubiquitin hydrolyzing enzyme I 
                 1689 
                 88 
               
               
                 725 
                 AF176531 
                   Mus musculus  F-box protein FBX16 
                 1412 
                 80 
               
               
                 726 
                 U10991 
                   Homo sapiens  G2 
                 756 
                 30 
               
               
                 727 
                 AE001795 
                   Thermotoga maritima  glycerol kinase 
                 845 
                 38 
               
               
                 728 
                 AJ006692 
                   Homo sapiens  ultra high sulfer keratin 
                 868 
                 71 
               
               
                 729 
                 Y76177 
                 Human secreted protein encoded by gene 54. 
                 866 
                 99 
               
               
                 730 
                 AL162295 
                   Arabidopsis thaliana  guanine nucleotide exchange factor-like protein 
                 261 
                 24 
               
               
                 731 
                 AF016036 
                   Drosophila tsacasi  repressor-like protein 
                 220 
                 27 
               
               
                 732 
                 Z54327 
                   Caenorhabditis elegans  contains similarity to Pfam domain: PF00070 
                 339 
                 32 
               
               
                   
                   
                 (pyridine nucleotide-disulphide oxidoreductase), 
               
               
                   
                   
                 Score = 82.7, E-value = 4e-24, N = 2 
               
               
                 733 
                 AC011713 
                   Arabidopsis thaliana  Contains similarity to gb|AF092102 G-protein 
                 303 
                 26 
               
               
                   
                   
                 beta subunit git5p from  Schizosaccharomyces pombe  and contains 
               
               
                   
                   
                 2 PF|00400WD doinain, G-beta repeat domains. 
               
               
                 734 
                 AL109965 
                   Homo sapiens  dJ1121G12.1.2 
                 323 
                 60 
               
               
                   
                   
                 (A novel protein containing a putative PPD finger domain, isoform 2) 
               
               
                 735 
                 AB000910 
                   Sus scrofa  ribosomal protein 
                 483 
                 87 
               
               
                 736 
                 Y07931 
                 Human secreted protein fragment encoded from gene 80. 
                 213 
                 100 
               
               
                 737 
                 M95718 
                   Oryctolagus cuniculus  keratin 
                 233 
                 65 
               
               
                 738 
                 AL034382 
                   Schizosaccharomyces pombe  putative Trp-Asp repeat protein 
                 453 
                 35 
               
               
                 739 
                 Y38401 
                 Human secreted protein encoded by gene No. 16. 
                 233 
                 88 
               
               
                 740 
                 U18917 
                   Saccharomyces cerevisiae  Yer157wp 
                 338 
                 26 
               
               
                 741 
                 W64471 
                 Human secreted protein from clone DF989_3. 
                 545 
                 97 
               
               
                 742 
                 AJ000474 
                   Homo sapiens  cytidine deaminase 
                 389 
                 100 
               
               
                 743 
                 AL132954 
                   Arabidopsis thaliana  putative protein 
                 361 
                 34 
               
               
                 744 
                 AF026292 
                   Homo sapiens  chaperonin containing t-complex polypeptide 1, 
                 890 
                 100 
               
               
                   
                   
                 eta subunit; CCT-eta 
               
               
                 745 
                 Y60251 
                 Human endometrium tumour EST encoded protein 311. 
                 392 
                 98 
               
               
                 746 
                 U07817 
                   Dictyostelium discoideum  glutamine-asparagine rich protein 
                 148 
                 30 
               
               
                 747 
                 M58529 
                   Homo sapiens  pro-alpha-2 type V collagen 
                 158 
                 100 
               
               
                 748 
                 AL118506 
                   Homo sapiens  dJ591C20.5 (KIAA1196) 
                 952 
                 45 
               
               
                 749 
                 AF181645 
                   Drosophila melanogaster  BcDNA.GH12144 
                 105 
                 54 
               
               
                 750 
                 AF067136 
                   Homo sapiens  protein phosphatase-1 regulatory subunit 7 alpha2 
                 147 
                 38 
               
               
                 751 
                 AJ006973 
                   Homo sapiens  TOM1 
                 638 
                 82 
               
               
                 752 
                 AF145664 
                   Drosophila melanogaster  BcDNA.GH11110 
                 766 
                 37 
               
               
                 753 
                 Z70310 
                   Caenorhabditis elegans  contains similarity to Pfam domain: PF00013 
                 510 
                 34 
               
               
                   
                   
                 (KH domain), Score = 42.8, E-value = 3.7e-12, N = 1; 
               
               
                   
                   
                 PF00023 (Ank repeat), Score = 428.2, E-value = 2.4e-125, N = 19 
               
               
                 754 
                 AF276514 
                   Mus musculus  105-kDa kinase-like protein 
                 3769 
                 88 
               
               
                 755 
                 Y30734 
                 Amino acid sequence of a human secreted protein. 
                 258 
                 96 
               
               
                 756 
                 AF102129 
                   Rattus norvegicus  KPL2 
                 1436 
                 79 
               
               
                 757 
                 L15313 
                   Caenorhabditis elegans  putative 
                 829 
                 58 
               
               
                 758 
                 AE003584 
                   Drosophila melanogaster  CG7289 gene product 
                 529 
                 34 
               
               
                 759 
                 Y66693 
                 Membrane-bound protein PRO1004. 
                 569 
                 92 
               
               
                 760 
                 AC007766 
                   Homo sapiens  R26610_1 
                 1574 
                 80 
               
               
                 761 
                 AF073958 
                   Homo sapiens  cytokine-inducible SH2 protein 6 
                 1142 
                 54 
               
               
                 762 
                 Z71181 
                   Caenorhabditis elegans  contains similarity to Pfam domain: PF00561 
                 498 
                 34 
               
               
                   
                   
                 (alpha/beta hydrolase fold) 
               
               
                   
                   
                 Score = 83.7, E-value = 1.2e-21, N = 1 
               
               
                 763 
                 AC005724 
                   Arabidopsis thaliana  putative C3HC4-type RING zinc finger protein 
                 166 
                 45 
               
               
                 764 
                 AF052433 
                   Strongylocentrotus purpuratus  katanin p80 subunit 
                 170 
                 30 
               
               
                 765 
                 X56044 
                   Mus musculus  protein Htf9C 
                 759 
                 44 
               
               
                 766 
                 U56418 
                   Homo sapiens  lysophosphatidic acid acyltransferase-beta 
                 834 
                 100 
               
               
                 767 
                 AK024388 
                   Homo sapiens  unnamed protein product 
                 675 
                 100 
               
               
                 768 
                 W67828 
                 Human secreted protein encoded by gene 22 clone HFEAF41. 
                 278 
                 100 
               
               
                 769 
                 AF055993 
                   Homo sapiens  mSin3A associated polypeptide p30 
                 637 
                 71 
               
               
                 770 
                 AK024512 
                   Homo sapiens  unnamed protein product 
                 454 
                 93 
               
               
                 771 
                 AF095844 
                   Homo sapiens  melanoma differentiation associated protein-5 
                 687 
                 40 
               
               
                 772 
                 AF169257 
                   Homo sapiens  sodium/calcium exchanger NCKX3 
                 3084 
                 99 
               
               
                 773 
                 D00824 
                   Gallus gallus  alpha 1 chain of type XII collagen 
                 302 
                 30 
               
               
                 774 
                 X82557 
                   Rattus norvegicus  myelin and lymphocyte protein 
                 257 
                 39 
               
               
                 775 
                 G03200 
                 Human secreted protein, SEQ ID NO: 7281. 
                 548 
                 98 
               
               
                 776 
                 AK024793 
                   Homo sapiens  unnamed protein product 
                 1730 
                 100 
               
               
                 777 
                 AB019397 
                   Homo sapiens  DNA topoisomerase II binding protein 
                 108 
                 23 
               
               
                 778 
                 AK025033 
                   Homo sapiens  unnamed protein product 
                 817 
                 99 
               
               
                 779 
                 AB028069 
                   Homo sapiens  activator of S phase Kinase 
                 474 
                 36 
               
               
                 780 
                 AF273052 
                   Homo sapiens  CTCL tumor antigen se70-2 
                 1294 
                 100 
               
               
                 781 
                 AF217512 
                   Homo sapiens  uncharacterized bone marrow protein BM036 
                 130 
                 100 
               
               
                 782 
                 AF121857 
                   Homo sapiens  sorting nexin 7 
                 2019 
                 100 
               
               
                 783 
                 AF305941 
                   Homo sapiens  LIM2 
                 933 
                 100 
               
               
                 784 
                 AF153085 
                   Homo sapiens  phosphoprotein pp75 
                 178 
                 31 
               
               
                 785 
                 AF106584 
                   Caenorhabditis elegans  contains similarity to homeobox domains 
                 255 
                 32 
               
               
                   
                   
                 (Pfam: PF00046, score = 16.2, E = 0.015, N = 1) 
               
               
                 786 
                 AF106584 
                   Caenorhabditis elegans  contains similarity to homeobox domains 
                 244 
                 31 
               
               
                   
                   
                 (Pfam: PF00046, score = 16.2, E = 0.015, N = 1) 
               
               
                 787 
                 AJ278508 
                   Mus musculus  MDM2 binding protein 
                 567 
                 76 
               
               
                 788 
                 Z21507 
                   Homo sapiens  human elongation factor-1-delta 
                 269 
                 96 
               
               
                 789 
                 AF096286 
                   Mus musculus  pecanex 1 
                 1498 
                 52 
               
               
                 790 
                 AC004882 
                   Homo sapiens  similar to calmodulin; similar to P24044 (PID: g115520) 
                 525 
                 60 
               
               
                 791 
                 AJ133500 
                   Xenopus laevis  p33 ringo 
                 547 
                 49 
               
               
                 792 
                 U41264 
                   Caenorhabditis elegans  coded for by  C. elegans  CDNA cm13gl; 
                 212 
                 50 
               
               
                   
                   
                 Similar to bumetanide-sensitive Na—K—Cl cotransporter 
               
               
                 793 
                 X16078 
                   Torpedo californica  4-acetamido-4′-isothiocyanostilbene-2,2′-disulphonic 
                 423 
                 38 
               
               
                   
                   
                 acid-binding protein 
               
               
                 794 
                 AK026447 
                   Homo sapiens  unnamed protein product 
                 833 
                 100 
               
               
                 795 
                 AL035417 
                   Homo sapiens  dJ891H21.1 (HYPOTHETICAL 43.1 KD PROTEIN) 
                 465 
                 100 
               
               
                 796 
                 M83751 
                   Homo sapiens  arginine-rich protein 
                 525 
                 62 
               
               
                 797 
                 AB037834 
                   Homo sapiens  KIAA1413 protein 
                 7273 
                 99 
               
               
                 798 
                 AB037834 
                   Homo sapiens  KIAA1413 protein 
                 6449 
                 98 
               
               
                 799 
                 AC011717 
                   Arabidopsis thaliana  putative carnitine/acylcarnitine translocase; 
                 450 
                 37 
               
               
                   
                   
                 50581-51656 
               
               
                 800 
                 AC069143 
                   Arabidopsis thaliana  Contains similarity to a transposable element Tip100 
                 305 
                 25 
               
               
                   
                   
                 protein for transposase from  Ipomoea purpurea  gb|4063769 and is a 
               
               
                   
                   
                 member of the transmembrane 4 family PF|00335. 
               
               
                 801 
                 AY008372 
                   Homo sapiens  oxysterol binding protein-related protein 3 
                 4671 
                 100 
               
               
                 802 
                 AC004557 
                   Arabidopsis thaliana  F17L21.20 
                 404 
                 39 
               
               
                 803 
                 AF182218 
                   Homo sapiens  epidermal lipoxygenase 
                 3830 
                 99 
               
               
                 804 
                 U90353 
                   Strongyloides stercoralis  IgG and IgE immuncreactive antigen recognized 
                 108 
                 35 
               
               
                   
                   
                 by sera from patients with strongyloidiasis 
               
               
                 805 
                 D13989 
                   Homo sapiens  human rho GDI 
                 818 
                 99 
               
               
                 806 
                 U00482 
                   Homo sapiens  gamma-subunit of rod cGMP-phosphodiesterase 
                 472 
                 100 
               
               
                 807 
                 Y19599 
                 SEQ ID NO 317 from WO9922243. 
                 590 
                 98 
               
               
                 808 
                 D50617 
                   Saccharomyces cerevisiae  YFL042C 
                 227 
                 31 
               
               
                 809 
                 X58430 
                   Homo sapiens  homeobox protein 
                 478 
                 100 
               
               
                 810 
                 M98539 
                   Homo sapiens  prostaglandin D2 synthase 
                 464 
                 97 
               
               
                 811 
                 AJ004872 
                   Homo sapiens  TCR beta chain 
                 1296 
                 92 
               
               
                 812 
                 G00329 
                 Human secreted protein, SEQ ID NO: 4410. 
                 524 
                 100 
               
               
                 813 
                 AL031431 
                   Homo sapiens  dJ462O23.2 (novel protein) 
                 824 
                 45 
               
               
                 814 
                 M37760 
                   Mus musculus  serine 2 ultra high sulfur protein 
                 633 
                 55 
               
               
                 815 
                 AL121673 
                   Homo sapiens  bA305P22.2 (novel protein) 
                 2396 
                 100 
               
               
                 816 
                 AB027568 
                   Mus musculus  thiamin pyrophosphokinase 
                 664 
                 91 
               
               
                 817 
                 M37190 
                   Homo sapiens  ras inhibitor 
                 792 
                 40 
               
               
                 818 
                 AL109659 
                   Homo sapiens  dJ1024N4.1 
                 2858 
                 100 
               
               
                   
                   
                 (novel Sodium:solute symporter family member similar to SLC5A1 
               
               
                   
                   
                 (SGLT1)) 
               
               
                 819 
                 AB000170 
                   Sus scrofa  endopeptidase 24.16 type M1 
                 3472 
                 94 
               
               
                 820 
                 AF058789 
                   Rattus norvegicus  SynGAP-a 
                 6651 
                 99 
               
               
                 821 
                 AK024408 
                   Homo sapiens  unnamed protein product 
                 1040 
                 100 
               
               
                 822 
                 Y08260 
                   Mus musculus  cytoplasmic polyadenylation element-binding protein (CPEB) 
                 2453 
                 95 
               
               
                 823 
                 Y36090 
                 Extended human secreted protein sequence, SEQ ID NO. 475. 
                 420 
                 95 
               
               
                 824 
                 AC003682 
                   Homo sapiens  R28530_2 
                 1398 
                 48 
               
               
                 825 
                 D89052 
                   Homo sapiens  proton-ATPase-like protein 
                 356 
                 100 
               
               
                 826 
                 AB039903 
                   Homo sapiens  interferon-responsive finger protein 1 long form 
                 978 
                 61 
               
               
                 827 
                 U96963 
                   Mus musculus  p140mDia 
                 471 
                 26 
               
               
                 828 
                 AJ251641 
                   Mus musculus  syncoilin 
                 656 
                 89 
               
               
                 829 
                 Z98595 
                   Schizosaccharomyces pombe  coronin-like protein 
                 196 
                 24 
               
               
                 830 
                 AF116660 
                   Homo sapiens  PRO1430 
                 299 
                 100 
               
               
                 831 
                 AJ277442 
                   Homo sapiens  xylosyltransferase II 
                 4625 
                 100 
               
               
                 832 
                 D86081 
                   Mus musculus  S-II-T1 
                 290 
                 36 
               
               
                 833 
                 L21671 
                   Mus musculus  Eps8 
                 547 
                 31 
               
               
                 834 
                 Z34801 
                   Caenorhabditis elegans  Similarity with drosphila MSP-300 protein 
                 283 
                 25 
               
               
                   
                   
                 (PIR acc. no. S30431) , contains similarity to Pfam domain: PF01465 
               
               
                   
                   
                 (GRIP domain), Score = 90.2, E-value = 1.4e-23, N = 1 
               
               
                 835 
                 AF264750 
                   Homo sapiens  ALR-like protein 
                 21361 
                 100 
               
               
                 836 
                 AF176814 
                   Mus musculus  Ab1-philin 2 
                 247 
                 41 
               
               
                 837 
                 AL121771 
                   Homo sapiens  dJ548G19.1.2 
                 166 
                 24 
               
               
                   
                   
                 (novel protein (ortholog of mouse zinc finger protein ZFP64) 
               
               
                   
                   
                 (translation of cDNA NT2RP4001938 (Em: AK001744)) (isoform 2)) 
               
               
                 838 
                 G00405 
                 Human secreted protein, SEQ ID NO: 4486. 
                 397 
                 98 
               
               
                 839 
                 AF130357 
                   Mus musculus domesticus  similar to RNA binding protein 
                 222 
                 53 
               
               
                 840 
                 AJ272034 
                   Homo sapiens  putative capacitative calcium channel 
                 4470 
                 100 
               
               
                 841 
                 G02337 
                 Human secreted protein, SEQ ID NO: 6418. 
                 377 
                 98 
               
               
                 842 
                 AF286475 
                   Takifugu rubripes  retinitis pigmentosa GTPase regulator-like protein 
                 226 
                 22 
               
               
                 843 
                 AB030183 
                   Mus musculus  contains transmembrane (TM) region 
                 1159 
                 89 
               
               
                 844 
                 Y18890 
                 Human endogenous retrovirus K gag protein 
                 273 
                 47 
               
               
                 845 
                 AC004890 
                   Homo sapiens  similar to HUB1; similar to BAA24380 (PID: g2789430) 
                 435 
                 79 
               
               
                 846 
                 Y66666 
                 Membrane-bound protein PRO1013. 
                 1858 
                 99 
               
               
                 847 
                 Y66666 
                 Membrane-bound protein PRO1013. 
                 1658 
                 93 
               
               
                 848 
                 AF119913 
                   Homo sapiens  PRO3077 
                 620 
                 100 
               
               
                 849 
                 Y36233 
                 Human secreted protein encoded by gene 10. 
                 302 
                 96 
               
               
                 850 
                 D14530 
                   Homo sapiens  ribosomal protein 
                 341 
                 100 
               
               
                 851 
                 AC011713 
                   Arabidopsis thaliana  Is a member of the PP|01553 Acyltransferase family. 
                 162 
                 39 
               
               
                 852 
                 Y36154 
                 Human secreted protein #26. 
                 296 
                 98 
               
               
                 853 
                 AC004877 
                   Homo sapiens  zinc finger-like; similar to P52742 (PID: g1731411) 
                 2830 
                 100 
               
               
                 854 
                 M34163 
                   Mus musculus  low affinity IgE receptor (FC-epsilon-RII) 
                 293 
                 29 
               
               
                 855 
                 X73579 
                   Rattus norvegicus  CD23 
                 333 
                 31 
               
               
                 856 
                 M34427 
                   Homo sapiens  T-plastin 
                 414 
                 98 
               
               
                 857 
                 Y19456 
                 Amino acid sequence of a human secreted protein. 
                 307 
                 90 
               
               
                 858 
                 AF067136 
                   Homo sapiens  protein phosphatase-1 regulatory subunit 7 betal 
                 199 
                 47 
               
               
                 859 
                 AC023279 
                   Arabidopsis thaliana  F12K21.21 
                 441 
                 38 
               
               
                 860 
                 G04069 
                 Human secreted protein, SEQ ID NO: 8150. 
                 491 
                 100 
               
               
                 861 
                 AP001297 
                   Arabidopsis thaliana gene _id:F14O13.28˜ 
                 488 
                 28 
               
               
                 862 
                 Y19587 
                 Amino acid sequence of a human secreted protein. 
                 160 
                 96 
               
               
                 863 
                 AB039861 
                   Schizosaccharomyces pombe  Esol 
                 201 
                 31 
               
               
                 864 
                 U34932 
                   Rattus norvegicus  Fos-related antigen 
                 2062 
                 84 
               
               
                 865 
                 Y60152 
                 Human endometrium tumour EST encoded protein 212. 
                 379 
                 100 
               
               
                 866 
                 AK027028 
                   Homo sapiens  unnamed protein product 
                 2294 
                 99 
               
               
                 867 
                 AF039718 
                   Caenorhabditis elegans  contains similarity to lupus LA protein homologs 
                 329 
                 44 
               
               
                 868 
                 AK024480 
                   Homo sapiens  FLJ00074 protein 
                 1001 
                 100 
               
               
                 869 
                 AF320909 
                   Homo sapiens  MAGE-E1 
                 634 
                 100 
               
               
                 870 
                 AF126484 
                   Homo sapiens  CARD4 
                 181 
                 30 
               
               
                 871 
                 Z83844 
                   Homo sapiens  dJ37E16.5 
                 651 
                 46 
               
               
                   
                   
                 (novel protein similar to nitrophenylphosphatases from various organisms) 
               
               
                 872 
                 AF128406 
                   Homo sapiens  nuclear prelamin A recognition factor 
                 1121 
                 47 
               
               
                 873 
                 Y16790 
                   Homo sapiens  keratin type I 
                 2029 
                 99 
               
               
                 874 
                 AJ006692 
                   Homo sapiens  ultra high sulfer keratin 
                 1073 
                 88 
               
               
                 875 
                 U43281 
                   Saccharomyces cerevisiae  Lpg21p 
                 323 
                 40 
               
               
                 876 
                 AF078844 
                   Homo sapiens  hqp0376 protein 
                 362 
                 81 
               
               
                 877 
                 AB025258 
                   Mus musculus  granuphilin-a 
                 3193 
                 90 
               
               
                 878 
                 D37991 
                   Homo sapiens  beta-signal sequence receptor 
                 847 
                 99 
               
               
                 879 
                 AL035427 
                   Homo sapiens  dJ769N13.1 (KIAA0443 protein.) 
                 510 
                 28 
               
               
                 880 
                 AL109925 
                   Homo sapiens  dJ534K7.2 (novel protein) 
                 3323 
                 100 
               
               
                 881 
                 AF254411 
                   Homo sapiens  ser/arg-rich pre-mRNA splicing factor SR-A1 
                 6833 
                 100 
               
               
                 882 
                 AL137082 
                   Arabidopsis thaliana  putative protein 
                 310 
                 42 
               
               
                 883 
                 M97188 
                   Strongylocentrotus purpuratus  tektin A1 
                 292 
                 40 
               
               
                 884 
                 Y10837 
                 Amino acid sequence of a human secreted protein. 
                 434 
                 100 
               
               
                 885 
                 Z12172 
                   Homo sapiens  putative homeotic protein 
                 1388 
                 79 
               
               
                 886 
                 AJ000479 
                   Homo sapiens  putative G-Protein coupled receptor, EDG6 
                 177 
                 30 
               
               
                 887 
                 X56044 
                   Mus musculus  protein Htf9C 
                 2360 
                 75 
               
               
                 888 
                 AC006963 
                   Homo sapiens  similar to Kelch proteins; similar to BAA77027 (PID: g4650844) 
                 268 
                 27 
               
               
                 889 
                 AF205357 
                   Drosophila melanogaster  extracellular matrix protein papilin 
                 503 
                 33 
               
               
                 890 
                 AB027757 
                   Cicer arietinum  NADPH oxidoreductase homolog 
                 719 
                 45 
               
               
                 891 
                 AL022140 
                   Arabidopsis thaliana  serine/threonine protein kinase like protein 
                 153 
                 30 
               
               
                 892 
                 AF286473 
                   Mus musculus  retinitis pigmentosa GTPase regulator 
                 208 
                 28 
               
               
                 893 
                 AL050328 
                   Homo sapiens  bA145L22.2 
                 2072 
                 99 
               
               
                   
                   
                 (novel KRAB box containing C2H2 type zinc finger protein) 
               
               
                 894 
                 AL096856 
                   Arabidopsis thaliana  putative protein 
                 223 
                 44 
               
               
                 895 
                 AF245517 
                   Homo sapiens  vacuolar proton pump 116 kDa accessory subunit 
                 4378 
                 100 
               
               
                 896 
                 AB000113 
                   Rattus norvegicus  cationic amino acid transporter 3 
                 2644 
                 83 
               
               
                 897 
                 AF142406 
                   Babesia bigemina  200 kDa antigen p200 
                 588 
                 24 
               
               
                 898 
                 AF062476 
                   Mus musculus  retinoic acid-responsive protein; STRA6 
                 2184 
                 75 
               
               
                 899 
                 Y48507 
                 Human breast tumour-associated protein 52. 
                 308 
                 98 
               
               
                 900 
                 U79745 
                   Homo sapiens  monocarboxylate transporter homologue MCT6 
                 465 
                 46 
               
               
                 901 
                 AF145661 
                   Drosophila melanogaster  BcDNA.GH10646 
                 376 
                 24 
               
               
                 902 
                 AC009519 
                   Arabidopsis thaliana  F1N19.17 
                 241 
                 29 
               
               
                 903 
                 Y27576 
                 Human secreted protein encoded by gene No. 10. 
                 394 
                 96 
               
               
                 904 
                 AF192968 
                   Homo sapiens  high-glucose-regulated protein 8 
                 2041 
                 67 
               
               
                 905 
                 AP001743 
                   Homo sapiens  putative gene, ankirin like, possible dual specifity 
                 4306 
                 99 
               
               
                   
                   
                 Ser/Thr/Tyr kinase domain 
               
               
                 906 
                 U71205 
                   Mus musculus  rit 
                 252 
                 35 
               
               
                 907 
                 M77003 
                   Mus musculus  glycerol-3-phosphate acyltransferase 
                 3366 
                 93 
               
               
                 908 
                 AF286368 
                   Homo sapiens  eppin-1 
                 222 
                 54 
               
               
                 909 
                 AC006439 
                   Arabidopsis thaliana  putative ADP-ribosylation factor 
                 261 
                 34 
               
               
                 910 
                 AF230808 
                   Homo sapiens  zinc finger transcription factor Pegasus 
                 2279 
                 99 
               
               
                 911 
                 AF134804 
                   Mus musculus  putative zinc finger transcription factor OVO1 
                 698 
                 52 
               
               
                 912 
                 AF049907 
                   Homo sapiens  zinc finger transcription factor 
                 530 
                 31 
               
               
                 913 
                 AF217319 
                   Mus musculus  putative repair and recominbination helicase RAD26L 
                 3218 
                 89 
               
               
                 914 
                 X80473 
                   Mus musculus  rab19 
                 1008 
                 88 
               
               
                 915 
                 U88315 
                   Caenorhabditis elegans  weak similarity to Plasmodium vivax 
                 609 
                 36 
               
               
                   
                   
                 reticulocyte-binding protein 2 (GI: 160628) 
               
               
                 916 
                 AF273052 
                   Homo sapiens  CTCL tumor antigen se70-2 
                 1237 
                 99 
               
               
                 917 
                 U34932 
                   Rattus norvegicus  Fos-related antigen 
                 2258 
                 84 
               
               
                 918 
                 AF116911 
                   Mus musculus  thymic dendritic cell-derived factor 1 
                 305 
                 92 
               
               
                 919 
                 AF205935 
                   Mus musculus  MGA protein 
                 4822 
                 84 
               
               
                 920 
                 AL157413 
                   Homo sapiens  bA526K17.1 (novel protein). 
                 1076 
                 100 
               
               
                 921 
                 Y10823 
                 Amino acid sequence of a human secreted protein. 
                 183 
                 100 
               
               
                 922 
                 Z97653 
                   Homo sapiens  c380A1.1b (novel protein) 
                 1106 
                 100 
               
               
                 923 
                 Z24725 
                   Homo sapiens  mitogen inducible gene mig-2 
                 1461 
                 56 
               
               
                 924 
                 AF113917 
                   Homo sapiens  NADP+-dependent isocitrate dehydrogenase 
                 1428 
                 100 
               
               
                 925 
                 AF064604 
                   Homo sapiens  KE03 protein 
                 1025 
                 57 
               
               
                 926 
                 AF064604 
                   Homo sapiens  KE03 protein 
                 972 
                 58 
               
               
                 927 
                 AL033545 
                   Arabidopsis thaliana  putative protein 
                 84 
                 35 
               
               
                 928 
                 AJ007014 
                   Homo sapiens  AMMECR1 protein 
                 733 
                 64 
               
               
                 929 
                 AJ276316 
                   Homo sapiens  zinc finger protein 304 
                 1007 
                 51 
               
               
                 930 
                 AC004077 
                   Arabidopsis thaliana  putative katanin 
                 877 
                 57 
               
               
                 931 
                 D16226 
                   Oryctolagus cuniculus  one of the members of sodium-glucose 
                 2008 
                 71 
               
               
                   
                   
                 cotransporter family 
               
               
                 932 
                 D16226 
                   Oryctolagus cuniculus  one of the members of sodium-glucose 
                 3026 
                 83 
               
               
                   
                   
                 cotransporter family 
               
               
                 933 
                 AF234676 
                   Sus scrofa  adipose differentiation-related protein 
                 336 
                 29 
               
               
                 934 
                 U70732 
                   Homo sapiens  glutamate pyruvate transaminase 
                 1821 
                 68 
               
               
                 935 
                 AB027004 
                   Homo sapiens  protein phosphatase 
                 462 
                 48 
               
               
                 936 
                 AF043180 
                   Homo sapiens  T cell receptor beta chain 
                 1097 
                 69 
               
               
                 937 
                 AC006528 
                   Arabidopsis thaliana  putative DNA replication licensing factor 
                 742 
                 41 
               
               
                 938 
                 L08483 
                   Drosophila melanogaster  ring canal protein 
                 660 
                 31 
               
               
                 939 
                 AL022238 
                   Homo sapiens  dJ1042K10.4 (novel protein) 
                 758 
                 46 
               
               
                 940 
                 AF275151 
                   Rattus norvegicus  androgen receptor-related apoptosis-associated protein 
                 619 
                 55 
               
               
                   
                   
                 CBL27 
               
               
                 941 
                 AF275151 
                   Rattus norvegicus  androgen receptor-related apoptosis-associated protein 
                 619 
                 55 
               
               
                   
                   
                 CBL27 
               
               
                 942 
                 AE000854 
                   Methanothermobacter thermoautotrophicus  Na+/H+-exchanging protein: 
                 498 
                 35 
               
               
                   
                   
                 Na+/H+ antiporter 
               
               
                 943 
                 D88894 
                   Homo sapiens  brain acyl-CoA hydrolase 
                 1742 
                 100 
               
               
                 944 
                 AP001072 
                   Oryza sativa  Similar to  Arabidopsis thaliana  DNA chromosome 4, 
                 248 
                 33 
               
               
                   
                   
                 BAC clone F22K18, putative protein. (AL035356) 
               
               
                 945 
                 AB033744 
                   Mus musculus  type II cytokeratin 
                 835 
                 74 
               
               
                 946 
                 AP186461 
                   Rattus norvegicus  ring finger protein Fxy 
                 351 
                 30 
               
               
                 947 
                 AK025539 
                   Homo sapiens  unnamed protein product 
                 2555 
                 99 
               
               
                 948 
                 J03407 
                   Homo sapiens  rfp transforming protein 
                 507 
                 40 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                 SEQ ID NO: 
                 ACCESSION NO. 
                 DESCRIPTION 
                 RESULTS* 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 2 
                 BL00972 
                 Ubiquitin carboxyl- 
                 BL00972A 11.93 2.500e-20 267-285 
               
               
                   
                   
                 terminal hydrolases 
                 BL00972D 22.55 5.179e-17 828-853 
               
               
                   
                   
                 family 2 proteins. 
                 BL00972E 20.72 8.650e-13 855-877 
               
               
                   
                   
                   
                 BL00972C 16.48 7.120e-11 411-426 
               
               
                   
                   
                   
                 BL00972B 9.45 7.923e-10 353-363 
               
               
                 3 
                 BL00018 
                 EF-hand calcium- 
                 BL00018 7.41 5.696e-09 331-344 
               
               
                   
                   
                 binding domain proteins. 
               
               
                 4 
                 BL00018 
                 EF-hand calcium- 
                 BL00018 7.41 5.696e-09 331-344 
               
               
                   
                   
                 binding domain proteins. 
               
               
                 5 
                 PR00401 
                 SH2 DOMAIN SIGNATURE 
                 PR00401B 12.94 1.000e-08 340-351 
               
               
                 6 
                 PR00401 
                 SH2 DOMAIN SIGNATURE 
                 PR00401B 12.94 1.000e-08 367-378 
               
               
                 7 
                 BL00625 
                 Regulator of chromosome 
                 BL00625A 16.21 7.787e-16 308-337 
               
               
                   
                   
                 condensation (RCC1) 
                 BL00625A 16.21 7.369e-15 190-219 
               
               
                   
                   
                 proteins. 
                 BL00625B 17.69 1.514e-13 302-336 
               
               
                   
                   
                   
                 BL00625B 17.69 2.286e-13 184-218 
               
               
                   
                   
                   
                 BL00625B 17.69 3.957e-13 132-166 
               
               
                   
                   
                   
                 BL00625A 16.21 5.690e-13 138-167 
               
               
                   
                   
                   
                 BL00625A 16.21 5.731e-11 360-389 
               
               
                   
                   
                   
                 BL00625B 17.69 3.333e-10 354-388 
               
               
                 9 
                 BL00120 
                 Lipases, serine proteins. 
                 BL00120B 11.37 9.486e-12 166-181 
               
               
                 15 
                 BL00183 
                 Ubiquitin-conjugating 
                 BL00183 28.97 1.329e-10 45-93 
               
               
                   
                   
                 enzymes proteins. 
               
               
                 18 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 6.034e-09 262-277 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 19 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 6.034e-09 74-89 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 20 
                 BL00790 
                 Receptor tyrosine 
                 BL00790D 12.41 8.297e-09 804-829 
               
               
                   
                   
                 kinase class V proteins. 
               
               
                 21 
                 BL00790 
                 Receptor tyrosine 
                 BL00790D 12.41 8.297e-09 878-903 
               
               
                   
                   
                 kinase class V proteins. 
               
               
                 23 
                 PR00380 
                 KINESIN HEAVY CHAIN 
                 PR00380D 9.93 2.080e-22 321-343 
               
               
                   
                   
                 SIGNATURE 
                 PR00380A 14.18 1.486e-21 79-101 
               
               
                   
                   
                   
                 PR00380B 12.64 6.571e-18 217-235 
               
               
                   
                   
                   
                 PR00380C 13.18 6.927e-13 269-288 
               
               
                 25 
                 BL01242 
                 Formamidopyrimidine- 
                 BL01242F 17.92 5.300e-11 32-66 
               
               
                   
                   
                 DNA glycosylase proteins. 
               
               
                 27 
                 PF00651 
                 BTB (also known as BR-C/Ttk) 
                 PF00651 15.00 2.500e-14 46-59 
               
               
                   
                   
                 domain proteins. 
               
               
                 28 
                 DM00215 
                 PROLINE-RICH PROTEIN 3. 
                 DM00215 19.43 3.898e-09 99-132 
               
               
                 29 
                 PR00380 
                 KINESIN HEAVY CHAIN 
                 PR00380A 14.18 9.250e-25 93-115 
               
               
                   
                   
                 SIGNATURE 
                 PR00380D 9.93 4.857e-19 302-324 
               
               
                   
                   
                   
                 PR00380B 12.64 4.429e-18 212-230 
               
               
                   
                   
                   
                 PR00380C 13.18 1.692e-16 247-266 
               
               
                 30 
                 BL00107 
                 Protein kinases ATP-binding 
                 BL00107A 18.39 3.368e-18 36-67 
               
               
                   
                   
                 region proteins. 
               
               
                 32 
                 BL00594 
                 Aromatic amino acids 
                 BL00594A 16.75 9.376e-09 76-120 
               
               
                   
                   
                 permeases proteins. 
               
               
                 34 
                 BL00790 
                 Receptor tyrosine 
                 BL00790E 29.58 1.111e-12 614-662 
               
               
                   
                   
                 kinase class V proteins. 
                 BL00790E 29.58 3.111e-12 668-716 
               
               
                   
                   
                   
                 BL00790E 29.58 7.000e-10 560-608 
               
               
                 38 
                 BL00290 
                 Immunoglobulins and 
                 BL00290A 20.89 4.150e-12 126-149 
               
               
                   
                   
                 major histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 39 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019A 11.19 6.087e-10 93-107 
               
               
                   
                   
                 SIGNATURE 
                 PR00019B 11.36 7.840e-09 90-104 
               
               
                 42 
                 PD01443 
                 INHIBITOR CALPAIN 
                 PD01443D 8.36 4.670e-09 815-837 
               
               
                   
                   
                 CALPASTATIN REPEAT 
               
               
                   
                   
                 THIOL PROT. 
               
               
                 43 
                 BL01101 
                 Casein kinase II 
                 BL01101A 16.07 1.000e-40 9-54 
               
               
                   
                   
                 regulatory subunit proteins. 
                 BL01101B 10.94 9.000e-31 72-97 
               
               
                 46 
                 BL01166 
                 RNA polymerases beta 
                 BL01166G 18.10 2.500e-34 824-866 
               
               
                   
                   
                 chain proteins. 
                 BL01166H 19.05 9.410e-30 936-986 
               
               
                   
                   
                   
                 BL01166D 17.37 4.396e-19 612-642 
               
               
                   
                   
                   
                 BL01166E 13.47 8.244e-17 682-706 
               
               
                   
                   
                   
                 BL01166C 12.21 9.357e-12 431-456 
               
               
                 47 
                 BL00518 
                 Zinc finger, C3HC4 type 
                 BL00518 12.23 7.000e-09 25-34 
               
               
                   
                   
                 (RING finger), proteins. 
               
               
                 48 
                 BL00038 
                 Myc-type, ′helix- 
                 BL00038A 13.61 6.625e-11 284-300 
               
               
                   
                   
                 loop-helix′ 
               
               
                   
                   
                 dimerization domain proteins. 
               
               
                 49 
                 BL00905 
                 GTP1/OBG family proteins. 
                 BL00905D 15.00 4.214e-10 125-140 
               
               
                 50 
                 BL00107 
                 Protein kinases ATP- 
                 BL00107B 13.31 7.300e-15 64-80 
               
               
                   
                   
                 binding region proteins. 
               
               
                 53 
                 BL00383 
                 Tyrosine specific 
                 BL00383E 10.35 5.263e-09 328-339 
               
               
                   
                   
                 protein phosphatases proteins. 
               
               
                 55 
                 BL00383 
                 Tyrosine specific 
                 BL00383E 10.35 5.263e-09 246-257 
               
               
                   
                   
                 protein phosphatases proteins. 
               
               
                 56 
                 BL00383 
                 Tyrosine specific 
                 BL00383E 10.35 5.263e-09 328-339 
               
               
                   
                   
                 protein phosphatases proteins. 
               
               
                 62 
                 BL00226 
                 Intermediate filaments proteins. 
                 BL00226B 23.86 5.919e-09 560-608 
               
               
                 64 
                 PR00322 
                 G10 PROTETN 
                 PR00322E 6.62 1.720e-10 30-40 
               
               
                 65 
                 BL00269 
                 Mammalian defensins proteins. 
                 BL00269C 16.52 6.786e-26 110-139 
               
               
                   
                   
                   
                 BL00269A 8.53 2.607e-20 45-65 
               
               
                   
                   
                   
                 BL00269B 19.17 5.500e-17 72-101 
               
               
                 66 
                 BL01160 
                 Kinesin light chain 
                 BL01160B 19.54 8.297e-10 6-60 
               
               
                   
                   
                 repeat proteins. 
               
               
                 67 
                 BL00028 
                 Zinc finger, C2H2 
                 BL00028 16.07 5.846e-11 476-493 
               
               
                   
                   
                 type, domain proteins. 
                 BL00028 16.07 6.192e-11 989-1006 
               
               
                 71 
                 BL00289 
                 Pentaxin family proteins. 
                 BL00289E 18.00 4.375e-13 22-37 
               
               
                 74 
                 BL00348 
                 p53 tumor antigen proteins. 
                 BL00348F 23.19 4.571e-09 140-183 
               
               
                 75 
                 BL00455 
                 Putative AMP-binding 
                 BL00455 13.31 6.684e-13 248-264 
               
               
                   
                   
                 domain proteins. 
               
               
                 78 
                 BL00421 
                 Transmembrane 4 
                 BL00421E 20.97 1.851e-09 17-47 
               
               
                   
                   
                 family proteins. 
               
               
                 80 
                 PD01066 
                 PROTEIN ZINC FINGER 
                 PD01066 19.43 2.149e-29 6-45 
               
               
                   
                   
                 ZINC-FINGER METAL- 
               
               
                   
                   
                 BINDINC NU. 
               
               
                 81 
                 PR00014 
                 FIBRONECTIN TYPE III 
                 PR00014D 12.04 2.059e-10 215-230 
               
               
                   
                   
                 REPEAT SIGNATURE 
               
               
                 84 
                 BL00269 
                 Mammalian defensins proteins. 
                 BL00269C 16.52 6.786e-26 133-162 
               
               
                   
                   
                   
                 BL00269A 8.53 2.607e-20 68-88 
               
               
                   
                   
                   
                 BL00269B 19.17 5.500e-17 95-124 
               
               
                 85 
                 PD01876 
                 ANTIGEN MELANOMA- 
                 PD01876C 21.73 1.231e-20 75-128 
               
               
                   
                   
                 ASSOCIATED MULTIGENE 
               
               
                   
                   
                 FAMILY TUM. 
               
               
                 86 
                 PD02870 
                 RECEPTOR 
                 PD02870B 18.83 8.835e-11 326-359 
               
               
                   
                   
                 INTERLEUKIN-1 
               
               
                   
                   
                 PRECURSOR. 
               
               
                 87 
                 PR00988 
                 URIDINE KINASE 
                 PR00988A 6.39 6.276e-12 386-376 
               
               
                   
                   
                 SIGNATURE 
               
               
                 90 
                 BL00120 
                 Lipases, serine proteins. 
                 BL00120C 12.62 9.053e-12 95-106 
               
               
                 96 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 5.500e-30 169-212 
               
               
                 100 
                 BL01128 
                 Shikimate kinase proteins. 
                 BL01128A 18.84 8.200e-14 7-41 
               
               
                 101 
                 PR00014 
                 FIBRONECTIN TYPE III 
                 PR00014C 15.44 1.783e-09 211-230 
               
               
                   
                   
                 REPEAT SIGNATURE 
                 PR00014A 8.22 3.045e-09 373-383 
               
               
                   
                   
                   
                 PR00014C 15.44 6.087e-09 309-328 
               
               
                 102 
                 DM00372 
                 CARCINOEMBRYONIC 
                 DM00372C 23.69 4.919e-12 67-103 
               
               
                   
                   
                 ANTIGEN PRECURSOR 
               
               
                   
                   
                 AMINO-TERMINAL 
               
               
                   
                   
                 DOMAIN. 
               
               
                 105 
                 BL01282 
                 BIR repeat proteins. 
                 BL01282B 30.49 1.000e-11 194-233 
               
               
                 109 
                 PR00464 
                 E-CLASS P450 GROUP 
                 PR00464A 20.47 9.591e-16 149-170 
               
               
                   
                   
                 II SIGNATURE 
                 PR00464C 18.84 1.000e-15 324-353 
               
               
                   
                   
                   
                 PR00464D 17.40 6.250e-15 353-371 
               
               
                   
                   
                   
                 PR00464B 20.41 1.844e-12 205-224 
               
               
                 110 
                 PD02382 
                 RECEPTOR CHAIN 
                 PD02382A 17.43 9.321e-09 99-115 
               
               
                   
                   
                 PRECURSOR TRANSME. 
               
               
                 112 
                 BL00795 
                 Involucrin proteins. 
                 BL00795C 17.06 6.442e-10 905-950 
               
               
                 115 
                 DM00215 
                 PROLINE-RICH PROTEIN 3. 
                 DM00215 19.43 6.644e-09 603-636 
               
               
                 116 
                 BL01282 
                 BIR repeat proteins. 
                 BL01282B 30.49 1.000e-11 137-176 
               
               
                 117 
                 BL01282 
                 BIR repeat proteins. 
                 BL01282B 30.49 1.000e-11 187-226 
               
               
                 118 
                 BL00218 
                 Amino acid permeases proteins. 
                 BL00218D 21.49 7.324e-11 226-271 
               
               
                   
                   
                   
                 BL00218E 23.30 3.475e-09 307-347 
               
               
                 119 
                 BL00994 
                 Bacterial export 
                 BL00994A 15.15 1.086e-09 71-118 
               
               
                   
                   
                 FHIPEP family proteins. 
               
               
                 120 
                 PD01066 
                 PROTEIN ZINC FINGER 
                 PD01066 19.43 8.385e-33 6-45 
               
               
                   
                   
                 ZINC-FINGER METAL- 
               
               
                   
                   
                 BINDING NU. 
               
               
                 121 
                 PD01427 
                 TRANSFERASE 
                 PD01427B 22.45 1.545e-11 117-158 
               
               
                   
                   
                 METHYLTRANSFERASE BI. 
               
               
                 122 
                 PF00168 
                 C2 domain proteins. 
                 PR00168C 27.49 1.750e-09 202-228 
               
               
                 127 
                 PR00962 
                 LETHAL(2) GIANT 
                 PR00962D 10.40 3.054e-10 178-202 
               
               
                   
                   
                 LARVAE PROTEIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 130 
                 DM01970 
                 0 kw ZK632.12 
                 DM01970B 8.60 2.478e-13 310-323 
               
               
                   
                   
                 YDR313C ENDOSOMAL III. 
               
               
                 131 
                 PF00774 
                 Dihydropyridine sensitive 
                 PF00774D 10.59 8.396e-09 339-365 
               
               
                   
                   
                 L-type calcium channel 
               
               
                   
                   
                 (Beta subuni. 
               
               
                 132 
                 BL00615 
                 C-type lectin domain proteins. 
                 BL00615A 16.68 3.160e-11 129-147 
               
               
                 133 
                 PD01066 
                 PROTEIN ZINC FINGER 
                 PD01066 19.43 2.705e-11 47-86 
               
               
                   
                   
                 ZINC-FINGER METAL- 
               
               
                   
                   
                 BINDING NU. 
               
               
                 134 
                 BL00359 
                 Ribosomal protein 
                 BL00359B 23.07 7.462e-24 160-201 
               
               
                   
                   
                 L11 proteins. 
                 BL00359C 22.18 6.586e-22 215-249 
               
               
                   
                   
                   
                 BL00359A 20.66 4.000e-21 124-160 
               
               
                 136 
                 PD02462 
                 PROTEIN BOLA 
                 PD02462A 22.48 1.220e-09 104-139 
               
               
                   
                   
                 TRANSCRIPTION 
               
               
                   
                   
                 REGULATION AC. 
               
               
                 137 
                 PR00679 
                 PROHIBITIN SIGNATURE 
                 PR00679F 8.03 6.478e-28 178-202 
               
               
                   
                   
                   
                 PR00679C 14.44 7.677e-22 107-126 
               
               
                   
                   
                   
                 PR00679E 12.82 5.171e-19 153-173 
               
               
                   
                   
                   
                 PR00679D 11.91 9.053e-18 130-147 
               
               
                   
                   
                   
                 PR00679G 6.13 7.882e-17 201-218 
               
               
                   
                   
                   
                 PR00679B 13.63 2.444e-10 84-104 
               
               
                 138 
                 PR00245 
                 OLFACTORY RECEPTOR 
                 PR00245E 12.40 8.286e-12 45-60 
               
               
                   
                   
                 SIGNATURE 
               
               
                 139 
                 PD00126 
                 PROTEIN REPEAT 
                 PD00126A 22.53 6.885e-10 99-120 
               
               
                   
                   
                 DOMAIN TPR NUCLEA. 
               
               
                 140 
                 BL01145 
                 Ribosomal protein 
                 BL01145A 13.73 1.000e-12 3-45 
               
               
                   
                   
                 L34e proteins. 
               
               
                 145 
                 BL00154 
                 E1-E2 ATPases 
                 BL00154D 12.57 7.387e-09 95-106 
               
               
                   
                   
                 phosphorylation site proteins. 
               
               
                 147 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 7.923e-15 439-452 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 2.800e-14 411-424 
               
               
                   
                   
                   
                 PD00066 13.92 2.800e-14 467-480 
               
               
                   
                   
                   
                 PD00066 13.92 5.800e-14 495-508 
               
               
                   
                   
                   
                 PD00066 13.92 5.800e-14 523-536 
               
               
                   
                   
                   
                 PD00066 13.92 8.200e-14 355-368 
               
               
                   
                   
                   
                 PD00066 13.92 5.500e-13 579-592 
               
               
                   
                   
                   
                 PD00066 13.92 3.143e-12 551-564 
               
               
                   
                   
                   
                 PD00066 13.92 4.857e-12 383-396 
               
               
                 149 
                 BL00649 
                 G-protein coupled 
                 BL00649C 17.82 9.542e-12 400-426 
               
               
                   
                   
                 receptors family 2 proteins. 
               
               
                 152 
                 BL00479 
                 Phorbol esters/diacylglycerol 
                 BL00479B 12.57 8.875e-09 886-902 
               
               
                   
                   
                 binding domain proteins. 
               
               
                 153 
                 PR00205 
                 CADHERIN SIGNATURE 
                 PR00205B 11.39 5.655e-16 255-273 
               
               
                   
                   
                   
                 PR00205A 14.73 1.000e-12 180-196 
               
               
                   
                   
                   
                 PR00205B 11.39 4.927e-10 475-493 
               
               
                   
                   
                   
                 PR00205C 13.65 9.438e-10 515-530 
               
               
                 155 
                 BL00122 
                 Carboxylesterases 
                 BL00122A 12.04 3.152e-15 86-107 
               
               
                   
                   
                 type-B serine proteins. 
                 BL00122D 12.53 7.097e-14 197-213 
               
               
                   
                   
                   
                 BL00122B 16.84 1.346e-13 148-159 
               
               
                   
                   
                   
                 BL00122C 7.91 9.550e-10 168-179 
               
               
                 157 
                 BL00018 
                 EF-hand calcium- 
                 BL00018 7.41 2.800e-10 217-230 
               
               
                   
                   
                 binding domain proteins. 
                 BL00018 7.41 8.650e-10 133-146 
               
               
                 160 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 6.143e-12 927-940 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 7.000e-09 343-356 
               
               
                 161 
                 DM01857 
                 5 kw NUCLEOSIDE 
                 DM01857B 14.94 6.471e-19 284-312 
               
               
                   
                   
                 TRANSPORT DEPENDENT 
                 DM01B57E 18.90 7.313e-18 488-527 
               
               
                   
                   
                 NA. 
                 DM01857F 12.86 7.045e-15 548-575 
               
               
                   
                   
                   
                 DM01857C 15.62 4.500e-14 312-344 
               
               
                   
                   
                   
                 DM01857A 20.25 1.667e-13 207-250 
               
               
                   
                   
                   
                 DM01857D 16.80 3.165e-12 372-410 
               
               
                 164 
                 DM01840 
                 kw SPAC24B11.09 
                 DM01840B 22.04 1.844e-40 59-103 
               
               
                   
                   
                 R07E5.13. 
                 DM01840A 10.95 9.571e-13 31-43 
               
               
                 166 
                 BL01115 
                 GTP-binding nuclear 
                 BL01115A 10.22 3.438e-14 53-97 
               
               
                   
                   
                 protein ran proteins. 
               
               
                 167 
                 PF00622 
                 Domain in SPla and 
                 PF00622B 21.00 2.500e-13 265-287 
               
               
                   
                   
                 the Ryanodine Receptor. 
               
               
                 168 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019A 11.19 5.050e-11 66-80 
               
               
                   
                   
                 SIGNATURE 
                 PR00019B 11.36 6.850e-10 63-77 
               
               
                 169 
                 BL00509 
                 Ras GTPase-activating 
                 BL00509B 10.28 5.263e-10 429-440 
               
               
                   
                   
                 proteins. 
               
               
                 172 
                 PR00720 
                 MAMMALIAN LMW 
                 PR00720C 12.41 1.099e-27 88-109 
               
               
                   
                   
                 PHOSPHOTYROSINE 
                 PR00720B 10.61 4.789e-20 71-87 
               
               
                   
                   
                 PROTEIN PHOSPHATASE 
                 PR00720A 16.54 2.000e-17 28-41 
               
               
                   
                   
                 SIGNATURE 
                 PR00720E 10.01 1.342e-16 117-139 
               
               
                   
                   
                   
                 PR00720D 17.32 1.778e-15 110-127 
               
               
                 173 
                 PD00131 
                 ATP-BINDING 
                 PD00131B 34.97 7.987e-09 108-162 
               
               
                   
                   
                 TRANSPORT 
               
               
                   
                   
                 TRANSMEMBR. 
               
               
                 175 
                 BL00615 
                 C-type lectin domain 
                 BL00615A 16.68 9.526e-13 573-591 
               
               
                   
                   
                 proteins. 
               
               
                 179 
                 BL00134 
                 Serine proteases, 
                 BL00134A 11.96 5.781e-15 493-510 
               
               
                   
                   
                 trypsin family, 
                 BL00134B 15.99 4.194e-14 675-699 
               
               
                   
                   
                 histidine proteins. 
               
               
                 180 
                 BL00236 
                 Neurotransmitter-gated 
                 BL00236D 25.66 4.000e-30 64-106 
               
               
                   
                   
                 ion-channels proteins. 
               
               
                 181 
                 BL00604 
                 Synaptophysin/ 
                 BL00604F 5.96 7.718e-10 367-412 
               
               
                   
                   
                 synaptoporin proteins. 
               
               
                 184 
                 PR00042 
                 FOS TRANSFORMING 
                 PR00042E 9.69 7.652e-09 234-258 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 187 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 9.400e-14 365-378 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 6.143e-12 335-348 
               
               
                   
                   
                   
                 PD00066 13.92 2.174e-11 395-408 
               
               
                 188 
                 BL00962 
                 Ribosomal protein S2 
                 BL00962D 22.51 5.500e-35 131-175 
               
               
                   
                   
                 proteins. 
                 BL00962C 15.90 9.591e-17 106-124 
               
               
                   
                   
                   
                 BL00962B 36.15 9.060e-15 40-94 
               
               
                 189 
                 BL00152 
                 ATP synthase alpha 
                 BL00152A 15.38 5.109e-14 128-154 
               
               
                   
                   
                 and beta subunits proteins. 
               
               
                 191 
                 BL00152 
                 ATP synthase alpha 
                 BL00152B 21.40 4.273e-37 124-162 
               
               
                   
                   
                 and beta subunits proteins. 
                 BL00152A 15.38 8.364e-23 67-93 
               
               
                 192 
                 BL00152 
                 ATP synthase alpha 
                 BL00152B 21.40 2.000e-32 185-223 
               
               
                   
                   
                 and beta subunits proteins. 
                 BL00152A 15.38 8.364e-23 128-154 
               
               
                 193 
                 PR00493 
                 BREAST CANCER TYPE I 
                 PR00493G 7.57 1.184e-10 652-673 
               
               
                   
                   
                 SUSCEPTIBILITY 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 195 
                 BL00301 
                 GTP-binding 
                 BL00301A 12.41 1.750e-12 72-84 
               
               
                   
                   
                 elongation factors proteins. 
               
               
                 197 
                 BL00745 
                 Prokaryotic-type 
                 BL00745C 13.66 7.398e-18 59-106 
               
               
                   
                   
                 class I peptide 
               
               
                   
                   
                 chain release 
               
               
                   
                   
                 factors signat. 
               
               
                 198 
                 BL00745 
                 Prokaryotic-type class I peptide 
                 BL00745C 13.66 4.706e-12 59-106 
               
               
                   
                   
                 chain release factors signat. 
               
               
                 201 
                 BL00660 
                 Band 4.1 family 
                 BL00660B 17.33 4.800e-27 136-176 
               
               
                   
                   
                 domain proteins. 
                 BL00660A 31.50 7.911e-20 52-105 
               
               
                   
                   
                   
                 BL00660C 23.36 2.241e-19 215-259 
               
               
                   
                   
                   
                 BL00660E 23.41 9.647e-13 301-324 
               
               
                 205 
                 PR00109 
                 TYROSINE KINASE 
                 PR00109B 12.27 1.882e-12 155-174 
               
               
                   
                   
                 CATALYTIC DOMAIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 207 
                 PR00837 
                 ALLERGEN V5/TPX-1 
                 PR00837C 17.21 4.064e-11 155-172 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00837A 14.77 4.960e-10 78-97 
               
               
                   
                   
                   
                 PR00837B 11.64 1.310e-09 133-147 
               
               
                 208 
                 BL01115 
                 GTP-binding nuclear 
                 BL01115A 10.22 8.909e-13 4-48 
               
               
                   
                   
                 protein ran proteins. 
               
               
                 211 
                 BL00175 
                 Phosphoglycerate 
                 BL00175D 27.67 4.000e-40 367-419 
               
               
                   
                   
                 mutase famiiy 
                 BL00175C 23.75 6.870e-28 316-348 
               
               
                   
                   
                 phosphohistidine 
                 BL00175A 15.42 8.200e-19 252-272 
               
               
                   
                   
                 proteins. 
                 BL00175B 12.60 8.714e-17 299-312 
               
               
                 212 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 1.000e-14 547-560 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 2.200e-14 353-366 
               
               
                   
                   
                   
                 PD00066 13.92 3.400e-14 241-254 
               
               
                   
                   
                   
                 PD00066 13.92 6.400e-14 325-338 
               
               
                   
                   
                   
                 PD00066 13.92 1.500e-13 297-310 
               
               
                   
                   
                   
                 PD00066 13.92 6.500e-13 465-478 
               
               
                   
                   
                   
                 PD00066 13.92 7.500e-13 437-450 
               
               
                   
                   
                   
                 PD00066 13.92 8.500e-13 409-422 
               
               
                   
                   
                   
                 PD00066 13.92 2.714e-12 269-282 
               
               
                   
                   
                   
                 PD00066 13.92 3.571e-12 381-394 
               
               
                   
                   
                   
                 PD00066 13.92 7.577e-10 519-532 
               
               
                 213 
                 PD02331 
                 CYCLIN CELL CYCLE 
                 PD02331C 13.84 1.913e-11 9-36 
               
               
                   
                   
                 DIVISION PROTE. 
               
               
                 215 
                 BL00239 
                 Receptor tyrosine 
                 BL00239B 25.15 3.915e-15 100-148 
               
               
                   
                   
                 kinase class II proteins. 
               
               
                 216 
                 BL01013 
                 Oxysterol-binding 
                 BL01013D 26.81 9.135e-22 501-545 
               
               
                   
                   
                 protein famiiy 
                 BL01013A 25.14 4.600e-14 220-256 
               
               
                   
                   
                 proteins. 
                 BL01013C 9.97 4.906e-12 330-340 
               
               
                   
                   
                   
                 BL01013B 11.33 3.017e-11 287-298 
               
               
                 219 
                 BL00289 
                 Pentaxin family protiens. 
                 BL00289A 30.36 6.850e-26 25-56 
               
               
                   
                   
                   
                 BL00289E 18.00 6.684e-14 78-93 
               
               
                 220 
                 PR00217 
                 43 KD POSTSYNAPTIC 
                 PR00217C 10.91 7.527e-09 547-563 
               
               
                   
                   
                 PROTEIN SIGNATRRE 
               
               
                 221 
                 PR00756 
                 MEMBRANE ALANYL 
                 PR00756D 10.58 1.529e-21 367-383 
               
               
                   
                   
                 DIPEPTIDASE (M1) 
                 PR00756B 14.06 5.737e-16 253-269 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00756A 12.90 1.237e-13 205-221 
               
               
                   
                   
                   
                 PR00756E 11.91 4.094e-13 386-399 
               
               
                   
                   
                   
                 PR00756C 11.60 6.108e-11 331-342 
               
               
                 222 
                 DM01688 
                 2 POLY-IG RECEPTOR. 
                 DM01688I 14.97 6.279e-09 75-123 
               
               
                 224 
                 PR00308 
                 TYPE I ANTIFREEZE 
                 PR00308C 3.83 2.523e-10 40-50 
               
               
                   
                   
                 PROTEIN SIGNATURE 
                 PR00308C 3.83 8.892e-10 41-51 
               
               
                   
                   
                   
                 PR00308C 3.83 8.892e-10 42-52 
               
               
                   
                   
                   
                 PR00308B 4.28 6.671e-09 40-52 
               
               
                 231 
                 BL00300 
                 SRP54-type proteins 
                 BL00300C 25.57 6.000e-09 215-269 
               
               
                   
                   
                 GTP-binding domain proteins. 
               
               
                 232 
                 BL00514 
                 Fibrinogen beta and gamma 
                 BL00514C 17.41 9.463e-19 233-270 
               
               
                   
                   
                 chains C-terminal domain 
                 BL00514E 14.28 7.750e-12 293-310 
               
               
                   
                   
                 proteins. 
                 BL00514D 15.35 9.824e-11 274-287 
               
               
                   
                   
                   
                 BL00514G 15.98 4.273e-10 356-386 
               
               
                   
                   
                   
                 BL00514H 14.95 6.217e-09 391-416 
               
               
                 233 
                 BL01158 
                 Macrophage migration 
                 BL01158A 21.81 4.130e-30 2-47 
               
               
                   
                   
                 inhibitory factor 
                 BL01158B 17.07 4.316e-29 47-74 
               
               
                   
                   
                 family proteins. 
               
               
                 234 
                 BL00456 
                 Sodium: solute 
                 BL00456A 22.59 6.250e-40 46-101 
               
               
                   
                   
                 symporter family 
                 BL00456C 24.55 6.586e-40 184-239 
               
               
                   
                   
                 proteins. 
                 BL00456B 18.94 8.125e-25 122-152 
               
               
                   
                   
                   
                 BL00456D 6.92 5.500e-10 476-486 
               
               
                 237 
                 PR00830 
                 ENDOPEPTIDASE LA (LON) 
                 PR00830A 8.41 4.780e-14 241-261 
               
               
                   
                   
                 SERINE PROTEASE (S16) 
               
               
                   
                   
                 SIGNATURE 
               
               
                 238 
                 PR00165 
                 ANION EXCHANGER 
                 PR00165I 10.02 8.412e-14 829-849 
               
               
                   
                   
                 SIGNATURE 
                 PR00165A 9.84 6.423e-13 495-518 
               
               
                   
                   
                   
                 PR00165B 15.26 9.090e-11 520-541 
               
               
                   
                   
                   
                 PR00165F 10.39 6.663e-10 639-658 
               
               
                 239 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 7.943e-14 65-108 
               
               
                 241 
                 BL00115 
                 Eukaryotic RNA polymerase II 
                 BL00115Z 3.12 2.047e-10 469-518 
               
               
                   
                   
                 heptapeptide repeat proteins. 
               
               
                 244 
                 BL01215 
                 Mrp family proteins. 
                 BL01215A 9.75 2.436e-09 466-493 
               
               
                 245 
                 PR00303 
                 PREPROTEIN 
                 PR00303G 10.45 8.759e-09 88-111 
               
               
                   
                   
                 TRANSLOCASE SECY 
               
               
                   
                   
                 SUBUNIT SIGNATURE 
               
               
                 249 
                 PF00429 
                 ENV polyprotein 
                 PF00429 31.08 8.015e-16 415-465 
               
               
                   
                   
                 (coat polyprotein). 
               
               
                 250 
                 BL00415 
                 Synapsins proteins. 
                 BL00415N 4.29 7.115e-10 224-268 
               
               
                 252 
                 BL00183 
                 Ubiquitin-conjugating 
                 BL00183 28.97 4.326e-22 81-129 
               
               
                   
                   
                 enzymes proteins. 
               
               
                 254 
                 BL00237 
                 G-protein coupled 
                 BL00237A 27.68 4.214e-16 108-148 
               
               
                   
                   
                 receptors proteins. 
                 BL00237C 13.19 3.323e-11 245-272 
               
               
                   
                   
                   
                 BL00237B 5.28 2.227e-09 182-194 
               
               
                 255 
                 BL00237 
                 G-protein coupled 
                 BL00237A 27.68 4.214e-16 108-148 
               
               
                   
                   
                 receptors proteins. 
                 BL00237C 13.19 3.323e-11 280-307 
               
               
                   
                   
                   
                 BL00237B 5.28 2.227e-09 217-229 
               
               
                 259 
                 PR00259 
                 TRANSMEMBRANE FOUR 
                 PR00259B 14.81 3.769e-21 50-77 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00259C 16.40 4.000e-20 77-106 
               
               
                   
                   
                   
                 PR00259A 9.27 3.600e-16 12-36 
               
               
                 260 
                 BL00282 
                 Kazal serine protease inhibitors 
                 BL00282 16.88 7.207e-14 562-585 
               
               
                   
                   
                 family proteins. 
               
               
                 261 
                 PF00922 
                 Vesiculovirus phosphoprotein. 
                 PF00922A 19.17 7.724e-09 88-122 
               
               
                 266 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 7.143e-10 17-32 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 267 
                 BL00612 
                 Osteonectin domain proteins. 
                 BL00612E 13.12 3.947e-11 379-424 
               
               
                 268 
                 BL00223 
                 Annexins repeat proteins 
                 BL00223A 15.59 1.000e-33 147-181 
               
               
                   
                   
                 domain proteins. 
                 BL00223A 15.59 1.435e-16 75-109 
               
               
                   
                   
                   
                 BL00223C 24.79 3.928e-15 134-189 
               
               
                 269 
                 BL00223 
                 Annexins repeat proteins 
                 BL00223B 28.47 1.000e-40 188-238 
               
               
                   
                   
                 domain proteins. 
                 BL00223A 15.59 1.000e-33 119-153 
               
               
                   
                   
                   
                 BL00223A 15.59 1.435e-16 47-81 
               
               
                   
                   
                   
                 BL00223C 24.79 3.928e-15 106-161 
               
               
                 270 
                 BL00223 
                 Annexins repeat proteins 
                 BL00223A 15.59 1.000e-33 119-153 
               
               
                   
                   
                 domain proteins. 
                 BL00223A 15.59 1.435e-16 47-81 
               
               
                   
                   
                   
                 BL00223C 24.79 3.928e-15 106-161 
               
               
                 273 
                 BL00086 
                 Cytochrome P450 cysteine 
                 BL00086 20.87 8.615e-27 423-455 
               
               
                   
                   
                 heme-iron ligand proteins. 
               
               
                 274 
                 PR00385 
                 P450 SUPERFAMILY 
                 PR00385A 14.97 5.696e-13 295-313 
               
               
                   
                   
                 SIGNATURE 
               
               
                 275 
                 BL00477 
                 Alpha-2-macroglobulin 
                 BL00477A 13.50 9.182e-19 70-99 
               
               
                   
                   
                 family thiolester region 
               
               
                   
                   
                 proteins. 
               
               
                 277 
                 BL00500 
                 Thymosin beta-4 family 
                 BL00500 9.77 2.565e-28 2-42 
               
               
                   
                   
                 proteins. 
               
               
                 279 
                 PR00320 
                 G-PROTEIN BETA WD-40 
                 PR00320A 16.74 4.971e-10 231-246 
               
               
                   
                   
                 REPEAT SIGNATURE 
                 PR00320C 13.01 8.200e-10 231-246 
               
               
                   
                   
                   
                 PR00320B 12.19 9.486e-10 231-246 
               
               
                   
                   
                   
                 PR00320B 12.19 3.475e-09 188-203 
               
               
                   
                   
                   
                 PR00320B 12.19 4.600e-09 315-330 
               
               
                   
                   
                   
                 PR00320C 13.01 4.900e-09 315-330 
               
               
                 288 
                 PF00580 
                 UvrD/REP helicase. 
                 PR00580D 13.15 8.920e-13 670-684 
               
               
                   
                   
                   
                 PF00580E 13.89 2.800e-11 867-886 
               
               
                   
                   
                   
                 PF00580F 8.62 9.438e-10 913-926 
               
               
                 289 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019B 11.36 1.000e-09 64-78 
               
               
                   
                   
                 SIGNATURE 
                 PR00019A 11.19 8.000e-09 90-104 
               
               
                 290 
                 PD00126 
                 PROTEIN REPEAT 
                 PD00126A 22.53 5.500e-10 229-250 
               
               
                   
                   
                 DOMAIN TPR NUCLEA. 
               
               
                 295 
                 DM01206 
                 CORONAVIRUS 
                 DM01206B 10.69 4.759e-09 464-484 
               
               
                   
                   
                 NUCLEOCAPSID PROTEIN. 
               
               
                 297 
                 BL00972 
                 Ubiquitin carboxyl-terminal 
                 BL00972A 11.93 8.054e-15 191-209 
               
               
                   
                   
                 hydrolases family 2 proteins. 
               
               
                 298 
                 PF00023 
                 Ank repeat proteins. 
                 PF00023A 16.03 9.500e-12 347-363 
               
               
                   
                   
                   
                 PF00023A 16.03 8.500e-10 283-299 
               
               
                   
                   
                   
                 PF00023A 16.03 8.875e-10 184-200 
               
               
                 300 
                 BL00415 
                 Synapsins proteins. 
                 BL00415Q 2.23 8.297e-09 13-49 
               
               
                 302 
                 BL01113 
                 C1q domain proteins. 
                 BL01113B 18.26 2.500e-13 841-877 
               
               
                 304 
                 BL01248 
                 Laminin-type EGF-like 
                 BL01248 11.02 7.171e-12 258-271 
               
               
                   
                   
                 (LE) domain proteins. 
                 BL01248 11.02 7.943e-12 325-338 
               
               
                 305 
                 BL00164 
                 Enolase proteins. 
                 BL00164A 11.58 2.800e-28 41-64 
               
               
                 307 
                 BL01153 
                 NOL1/NOP2/sun family 
                 BL01153D 19.69 8.322e-14 102-128 
               
               
                   
                   
                 proteins. 
                 BL01153C 13.67 6.507e-10 51-65 
               
               
                 308 
                 BL00892 
                 HIT family proteins. 
                 BL00892B 16.86 1.000e-20 130-154 
               
               
                   
                   
                   
                 BL00892A 18.17 6.657e-20 64-95 
               
               
                 309 
                 PF00791 
                 Domain present in ZO-1 and 
                 PF00791B 28.49 4.146e-10 73-128 
               
               
                   
                   
                 Unc5-like netrin receptors. 
               
               
                 310 
                 BL00615 
                 C-type lectin domain proteins. 
                 BL00615B 12.25 5.200e-12 166-180 
               
               
                 311 
                 BL00071 
                 Glyceraldehyde 3-phosphate 
                 BL00071B 21.70 1.000e-40 80-126 
               
               
                   
                   
                 dehydrogenase proteins. 
                 BL00071C 11.81 1.000e-40 146-181 
               
               
                   
                   
                   
                 BL00071D 19.39 3.118e-25 184-239 
               
               
                   
                   
                   
                 BL00071E 11.48 4.600e-24 308-329 
               
               
                   
                   
                   
                 BL00071A 5.81 2.607e-14 5-17 
               
               
                 314 
                 PR00926 
                 MITOCHONDRIAL 
                 PR00926F 17.75 2.688e-10 15-38 
               
               
                   
                   
                 CARRIER PROTEIN 
                 PR00926D 10.53 6.625e-10 21-40 
               
               
                   
                   
                 SIGNATURE 
               
               
                 315 
                 PR00654 
                 ANGIOTENSINOGEN 
                 PR00654A 15.64 1.540e-26 23-44 
               
               
                   
                   
                 SIGNATURE 
                 PR00654D 10.48 3.538e-26 153-175 
               
               
                   
                   
                   
                 PR00654F 15.16 8.071e-26 255-275 
               
               
                   
                   
                   
                 PR00654E 9.81 2.241e-25 194-215 
               
               
                   
                   
                   
                 PR006540 9.50 5.500e-21 115-135 
               
               
                 316 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 8.071e-17 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 317 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 7.600e-16 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 318 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 2.800e-16 31-54 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 319 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 9.400e-16 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 320 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290B 13.17 4.000e-21 282-300 
               
               
                   
                   
                 histocompatibility 
                 BL00290A 20.89 4.600e-16 34-57 
               
               
                   
                   
                 complex proteins. 
                 BL00290A 20.89 2.421e-13 225-248 
               
               
                 321 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 4.600e-16 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 323 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 8.071e-17 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 324 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 4.600e-16 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 325 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 4.600e-16 34-57 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 326 
                 PF00651 
                 BTB (also known as BR-C/Ttk) 
                 PF00651 15.00 2.500e-14 46-59 
               
               
                   
                   
                 domain proteins. 
               
               
                 333 
                 BL00972 
                 Ubiquitin carboxyl- 
                 BL00972A 11.93 3.919e-15 101-119 
               
               
                   
                   
                 terminal hydrolases 
                 BL00972B 9.45 7.577e-10 180-190 
               
               
                   
                   
                 family 2 proteins. 
               
               
                 337 
                 PF00789 
                 Domain present in 
                 PF00789B 19.70 5.941e-09 213-234 
               
               
                   
                   
                 ubiquitin-regulatory proteins. 
               
               
                 338 
                 PF00789 
                 Domain present in 
                 PF00789B 19.70 5.941e-09 259-280 
               
               
                   
                   
                 ubiquitin-regulatory proteins. 
               
               
                 339 
                 PR00625 
                 DNAJ PROTEIN FAMILY 
                 PR00625A 12.84 3.000e-19 19-39 
               
               
                   
                   
                 SIGNATURE 
                 PR00625B 13.48 2.756e-17 47-68 
               
               
                 340 
                 BL00518 
                 Zinc finger, C3HC4 type 
                 BL00518 12.23 5.714e-10 24-33 
               
               
                   
                   
                 (RING finger) proteins. 
               
               
                 341 
                 PR00500 
                 POLYCYSTIC KIDNEY 
                 PR00500I 9.22 1.107e-31 2810-2833 
               
               
                   
                   
                 DISEASE PROTEIN 
                 PR00500G 3.68 1.087e-30 2525-2548 
               
               
                   
                   
                 SIGNATURE 
                 PR00500H 17.80 1.107e-29 2662-2684 
               
               
                   
                   
                   
                 PR00500E 6.99 1.106e-27 2350-2370 
               
               
                   
                   
                   
                 PR00500F 9.44 1.108e-26 2483-2503 
               
               
                 343 
                 BL00415 
                 Synapsins proteins. 
                 BL00415N 4.29 5.401e-09 136-180 
               
               
                 344 
                 PD00930 
                 PROTEIN GTPASE 
                 PD00930B 33.72 2.800e-23 229-270 
               
               
                   
                   
                 DOMAIN ACTIVATION. 
                 PD00930A 25.62 5.021e-12 125-151 
               
               
                 345 
                 BL00023 
                 Type II fibronectin 
                 BL00023 24.31 8.043e-34 281-318 
               
               
                   
                   
                 collagen-binding 
                 BL00023 24.31 5.320e-32 223-260 
               
               
                   
                   
                 domain proteins. 
                 BL00023 24.31 5.800e-29 340-377 
               
               
                 346 
                 BL00023 
                 Type II fibronectin 
                 BL00023 24.31 8.043e-34 281-318 
               
               
                   
                   
                 collagen-binding 
                 BL00023 24.31 5.320e-32 223-260 
               
               
                   
                   
                 domain proteins. 
                 BL00023 24.31 5.800e-29 340-377 
               
               
                 350 
                 DM01354 
                 kw TRANSCRIPTASE 
                 DM01354R 8.50 2.969e-22 2115-2145 
               
               
                   
                   
                 REVERSE II ORF2. 
                 DM01354S 11.61 1.692e-14 2145-2166 
               
               
                 351 
                 BL00888 
                 Cyclic nucleotide- 
                 BL00888B 14.79 4.706e-18 372-396 
               
               
                   
                   
                 binding domain proteins. 
                 BL00868A 18.03 1.000e-08 354-371 
               
               
                 353 
                 PF00615 
                 Regulator of G protein 
                 PR00615B 16.25 9.625e-16 73-90 
               
               
                   
                   
                 signalling domain proteins. 
                 PR00615C 10.06 9.206e-12 150-164 
               
               
                 354 
                 BL00766 
                 Tetrahydrofolate 
                 BL00766E 13.78 9.625e-39 191-228 
               
               
                   
                   
                 dehydrogenase/cyclohydrolase 
                 BL00766C 25.86 4.375e-31 77-125 
               
               
                   
                   
                 proteins. 
                 BL00766D 17.05 5.966e-25 152-182 
               
               
                 355 
                 BL00180 
                 Glutamine synthetase proteins. 
                 BL00180E 17.60 1.000e-40 154-206 
               
               
                   
                   
                   
                 BL00180D 13.26 2.174e-24 119-141 
               
               
                   
                   
                   
                 BL00180F 10.05 6.211e-17 218-231 
               
               
                   
                   
                   
                 BL00180G 10.20 8.435e-17 307-322 
               
               
                   
                   
                   
                 BL00180C 12.14 4.600e-14 102-112 
               
               
                   
                   
                   
                 BL00180B 18.03 4.971e-14 68-87 
               
               
                   
                   
                   
                 BL00180A 13.20 5.065e-14 32-45 
               
               
                 356 
                 BL00180 
                 Glutamine synthetase proteins. 
                 BL00180F 10.05 6.750e-15 49-62 
               
               
                 358 
                 BL01131 
                 Ribosomal RNA adenine 
                 BL01131A 26.62 1.000e-08 77-123 
               
               
                   
                   
                 dimethylases proteins. 
               
               
                 360 
                 DM00191 
                 w SPAC8A4.04C 
                 DM00191A 8.16 5.440e-09 36-49 
               
               
                   
                   
                 RESISTANCE SPAC8A4.05C 
               
               
                   
                   
                 DAUNORUBICIN. 
               
               
                 361 
                 DM00191 
                 w SPAC8A4.04C 
                 DM00191A 8.16 5.440e-09 61-74 
               
               
                   
                   
                 RESISTANCE SPAC8A4.05C 
               
               
                   
                   
                 DAUNORUBICIN. 
               
               
                 362 
                 PF00606 
                 Herpesviral Glycoprotein B. 
                 PF00606I 20.74 7.894e-09 264-316 
               
               
                 363 
                 PR00209 
                 ALPHA/BETA GLIADIN 
                 PR00209B 4.88 9.080e-11 80-99 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00209B 4.88 6.967e-10 86-105 
               
               
                 364 
                 PR00528 
                 GLUCOCORTICOID 
                 PR00528F 9.13 9.063e-09 31-51 
               
               
                   
                   
                 RECEPTOR SIGNATURE 
               
               
                 365 
                 PF00622 
                 Domain in SPla and the 
                 PF00622C 12.62 6.625e-13 759-773 
               
               
                   
                   
                 RYanodine Receptor. 
               
               
                 366 
                 BL00420 
                 Speract receptor repeat 
                 BL00420B 22.67 2.824e-25 37-92 
               
               
                   
                   
                 proteins domain proteins. 
                 BL00420C 11.90 9.250e-12 122-133 
               
               
                 367 
                 PR00080 
                 ALCOHOL 
                 PR00080A 9.32 8.548e-10 122-134 
               
               
                   
                   
                 DEHYDROGENASE 
               
               
                   
                   
                 SUPERFAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 369 
                 BL00263 
                 Natriuretic peptides proteins. 
                 BL00263 11.87 5.909e-22 129-147 
               
               
                 370 
                 BL00609 
                 Glycosyl hydrolases family 
                 BL00609C 13.27 9.270e-11 249-261 
               
               
                   
                   
                 32 proteins. 
               
               
                 371 
                 PR00237 
                 RHODOPSIN-LIKE GPCR 
                 PR00237E 13.03 4.000e-10 26-50 
               
               
                   
                   
                 SUPERFAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 372 
                 BL00125 
                 Serine/threonine specific 
                 BL00125D 33.11 9.719e-35 23-78 
               
               
                   
                   
                 protein phosphatases proteins. 
               
               
                 373 
                 BL00453 
                 FKBP-type peptidyl-prolyl 
                 BL00453B 23.86 6.538e-26 281-315 
               
               
                   
                   
                 cis-trans isomerase proteins. 
                 BL00453A 15.57 8.364e-12 249-264 
               
               
                   
                   
                   
                 BL00453C 9.72 3.250e-11 323-336 
               
               
                 374 
                 PR00497 
                 NEUTROPHIL CYTOSOL 
                 PR00497A 6.92 8.261e-09 310-328 
               
               
                   
                   
                 FACTOR P40 SIGNATURE 
               
               
                 375 
                 PR00449 
                 TRANSFORMING PROTEIN 
                 PR00449A 13.20 8.269e-16 34-56 
               
               
                   
                   
                 P21 RAS SIGNATURE 
               
               
                 376 
                 PR00109 
                 TYROSINE KINASE 
                 PR00109B 12.27 9.847e-10 314-333 
               
               
                   
                   
                 CATALYTIC DOMAIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 377 
                 PR00109 
                 TYROSINE KINASE 
                 PR00109B 12.27 9.847e-10 314-333 
               
               
                   
                   
                 CATALYTIC DOMAIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 378 
                 BL00472 
                 Small cytokines 
                 BL00472C 20.76 8.225e-09 50-87 
               
               
                   
                   
                 (intercrine/chemokine) 
               
               
                   
                   
                 C—C subfamily signatur. 
               
               
                 379 
                 PR00704 
                 CALPAIN CYSTEINE 
                 PR007040 11.88 6.162e-09 132-149 
               
               
                   
                   
                 PROTEASE (C2) FAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 380 
                 PR00705 
                 PAPAIN CYSTEINE 
                 PR00705A 10.55 8.667e-13 155-171 
               
               
                   
                   
                 PROTEASE (C1) FAMILY 
                 PR00705B 10.22 2.385e-10 334-345 
               
               
                   
                   
                 SIGNATURE 
               
               
                 382 
                 PD01270 
                 RECEPTOR FC 
                 PD01270A 17.22 7.443e-10 129-169 
               
               
                   
                   
                 IMMUNOGLOBULIN 
                 PD01270A 17.22 7.387e-09 36-76 
               
               
                   
                   
                 AFFIN. 
               
               
                 384 
                 BL00412 
                 Neuromodulin (GAP-43) 
                 BL00412D 16.54 6.772e-10 250-301 
               
               
                   
                   
                 proteins. 
               
               
                 385 
                 BL00232 
                 Cadherins extracellular 
                 BL00232B 32.79 8.594e-35 151-199 
               
               
                   
                   
                 repeat proteins domain 
                 BL00232B 32.79 5.579e-22 260-308 
               
               
                   
                   
                 proteins. 
                 BL00232A 27.72 1.000e-20 57-90 
               
               
                   
                   
                   
                 BL00232C 10.65 3.613e-14 258-276 
               
               
                   
                   
                   
                 BL00232B 32.79 4.872e-11 377-425 
               
               
                   
                   
                   
                 BL00232C 10.65 3.211e-09 480-498 
               
               
                 387 
                 BL00214 
                 Cytosolic fatty-acid 
                 BL00214B 26.51 9.000e-29 47-92 
               
               
                   
                   
                 binding proteins. 
                 BL00214A 21.17 1.000e-24 6-32 
               
               
                 388 
                 PR00452 
                 SH3 DOMAIN SIGNATURE 
                 PR00452B 11.65 8.250e-09 509-525 
               
               
                 390 
                 BL00972 
                 Ubiquitin carboxyl-terminal 
                 BL00972A 11.93 8.759e-17 112-130 
               
               
                   
                   
                 hydrolases family 2 proteins. 
                 BL00972D 22.55 8.116e-12 354-379 
               
               
                   
                   
                   
                 BL00972B 9.45 7.088e-09 193-203 
               
               
                 392 
                 BL00243 
                 Integrins beta chain 
                 BL00243I 31.77 3.155e-09 1-44 
               
               
                   
                   
                 cysteine-rich domain proteins. 
               
               
                 394 
                 BL00476 
                 Fatty acid desaturases family 1 
                 BL00476F 12.75 6.551e-09 45-90 
               
               
                   
                   
                 proteins. 
               
               
                 397 
                 PR00320 
                 G-PROTEIN BETA WD-40 
                 PR00320A 16.74 9.690e-11 292-307 
               
               
                   
                   
                 REPEAT SIGNATURE 
                 PR00320B 12.19 4.343e-10 292-307 
               
               
                   
                   
                   
                 PR00320C 13.01 7.840e-10 292-307 
               
               
                 402 
                 PD01823 
                 PROTEIN INTERGENIC 
                 PD01823D 16.66 3.093e-15 21-42 
               
               
                   
                   
                 REGION ABC1 PRECURSOR 
                 PD01823E 9.30 5.909e-15 75-88 
               
               
                   
                   
                 MITOCHONDRION T. 
               
               
                 404 
                 BL00540 
                 Ferritin iron-binding regions 
                 BL00540A 15.06 1.000e-40 9-50 
               
               
                   
                   
                 proteins. 
                 BL00540B 18.82 1.000e-40 100-155 
               
               
                   
                   
                   
                 BL00540C 13.00 7.500e-15 165-177 
               
               
                 405 
                 PR00294 
                 STREPTOMYCES 
                 PR00294A 10.44 6.444e-10 159-186 
               
               
                   
                   
                 SUBTILISIN INHIBITOR 
               
               
                   
                   
                 SIGNATURE 
               
               
                 408 
                 BL00428 
                 Cell cycle proteins 
                 BL00428A 14.30 3.613e-09 91-110 
               
               
                   
                   
                 ftsW/rodA/spoVE proteins. 
               
               
                 411 
                 BL00142 
                 Neutral zinc metallopeptidases, 
                 BL00142 8.38 7.188e-10 389-400 
               
               
                   
                   
                 zinc-binding region proteins. 
               
               
                 412 
                 DM00191 
                 w SPAC8A4.04C 
                 DM00191D 13.94 6.330e-11 232-271 
               
               
                   
                   
                 RESISTANCE 
                 DM00191D 13.94 7.728e-11 48-87 
               
               
                   
                   
                 SPAC8A4.05C 
                 DM00191D 13.94 5.000e-10 112-151 
               
               
                   
                   
                 DAUNORUBICIN. 
                 DM00191D 13.94 5.667e-10 59-98 
               
               
                   
                   
                   
                 DM00191D 13.94 5.667e-10 123-162 
               
               
                   
                   
                   
                 DM00191D 13.94 6.583e-10 56-95 
               
               
                   
                   
                   
                 DM00191D 13.94 8.417e-10 280-319 
               
               
                   
                   
                   
                 DM00191D 13.94 8.917e-10 192-231 
               
               
                   
                   
                   
                 DM00191D 13.94 1.391e-09 224-263 
               
               
                   
                   
                   
                 DM00191D 13.94 2.409e-09 208-247 
               
               
                   
                   
                   
                 DM00191D 13.94 4.835e-09 120-159 
               
               
                   
                   
                   
                 DM00191D 13.94 5.304e-09 149-188 
               
               
                   
                   
                   
                 DM00191D 13.94 5.461e-09 211-250 
               
               
                   
                   
                   
                 DM00191D 13.94 6.322e-09 80-119 
               
               
                   
                   
                   
                 DM00191D 13.94 7.652e-09 243-282 
               
               
                   
                   
                   
                 DM00191D 13.94 8.513e-09 216-255 
               
               
                   
                   
                   
                 DM00191D 13.94 9.452e-09 177-216 
               
               
                 415 
                 PR00023 
                 Ank repeat proteins. 
                 PR00023A 16.03 1.321e-09 110-126 
               
               
                 418 
                 PF00168 
                 C2 domain proteins. 
                 PR00168C 27.49 9.250e-17 320-346 
               
               
                 419 
                 PF00168 
                 C2 domain proteins. 
                 PR00168C 27.49 9.250e-17 320-346 
               
               
                 420 
                 BL00086 
                 Cytochrome P450 cysteine 
                 BL00086 20.87 1.857e-20 444-476 
               
               
                   
                   
                 heme-iron ligand proteins. 
               
               
                 422 
                 BL00218 
                 Amino acid permeases 
                 BL00218D 21.49 9.757e-11 263-308 
               
               
                   
                   
                 proteins. 
               
               
                 423 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 3.288e-09 35-50 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 424 
                 PR00380 
                 KINESIN HEAVY CHAIN 
                 PR00380A 14.18 4.086e-22 84-106 
               
               
                   
                   
                 SIGNATURE 
                 PR00380C 13.18 5.286e-17 240-259 
               
               
                   
                   
                   
                 PR00380D 9.93 7.698e-17 290-312 
               
               
                   
                   
                   
                 PR00380B 12.64 7.805e-14 207-225 
               
               
                 425 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 1.915e-09 590-605 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 426 
                 BL00411 
                 Kinesin motor domain 
                 BL00411H 15.66 7.811e-22 79-110 
               
               
                   
                   
                 proteins. 
                 BL00411G 21.39 8.683e-22 31-73 
               
               
                 428 
                 BL00790 
                 Receptor tyrosine kinase 
                 BL00790E 29.58 6.667e-12 767-815 
               
               
                   
                   
                 class V proteins. 
               
               
                 429 
                 BL00048 
                 Protamine P1 proteins. 
                 BL00048 6.39 4.038e-09 396-423 
               
               
                 433 
                 BL00107 
                 Protein kinases ATP-binding 
                 BL00107A 18.39 8.500e-27 342-373 
               
               
                   
                   
                 region proteins. 
               
               
                 434 
                 PR00910 
                 LUTEOVIRUS ORF6 
                 PR00910A 2.51 6.036e-09 48-61 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 440 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019A 11.19 7.261e-10 69-83 
               
               
                   
                   
                 SIGNATURE 
                 PR00019B 11.36 4.600e-09 66-80 
               
               
                 444 
                 BL00018 
                 EF-hand calcium-binding 
                 BL00018 7.41 6.870e-09 42-55 
               
               
                   
                   
                 domain proteins. 
               
               
                 448 
                 BL00790 
                 Receptor tyrosine 
                 BL00790B 21.59 1.000e-40 61-113 
               
               
                   
                   
                 kinase class V proteins. 
                 BL00790C 16.65 1.000e-40 165-219 
               
               
                   
                   
                   
                 BL00790K 9.30 1.000e-40 657-711 
               
               
                   
                   
                   
                 BL00790Q 15.61 1.000e-40 855-904 
               
               
                   
                   
                   
                 BL00790O 7.68 5.929e-39 797-830 
               
               
                   
                   
                   
                 BL00790G 22.06 5.114e-36 376-420 
               
               
                   
                   
                   
                 BL00790R 16.20 7.469e-36 951-995 
               
               
                   
                   
                   
                 BL00790E 29.58 7.250e-35 273-321 
               
               
                   
                   
                   
                 BL00790J 14.21 8.200e-33 605-645 
               
               
                   
                   
                   
                 BL00790N 13.25 1.214e-31 763-790 
               
               
                   
                   
                   
                 BL00790I 20.01 1.931e-29 501-532 
               
               
                   
                   
                   
                 BL00790D 12.41 2.500e-27 243-268 
               
               
                   
                   
                   
                 BL00790H 13.42 6.478e-27 455-481 
               
               
                   
                   
                   
                 BL00790M 8.74 8.683e-25 741-763 
               
               
                   
                   
                   
                 BL00790P 12.33 3.755e-24 830-855 
               
               
                   
                   
                   
                 BL00790F 15.90 5.200e-24 339-366 
               
               
                   
                   
                   
                 BL00790L 11.16 5.909e-21 721-741 
               
               
                   
                   
                   
                 BL00790A 19.74 1.964e-19 31-53 
               
               
                 453 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 2.000e-11 84-127 
               
               
                 455 
                 BL01160 
                 Kinesin light chain 
                 BL01160B 19.54 5.958e-09 387-441 
               
               
                   
                   
                 repeat proteins. 
               
               
                 456 
                 BL01113 
                 Clq domain proteins. 
                 BL01113B 18.26 2.500e-13 841-877 
               
               
                 458 
                 BL01206 
                 Amiloride-sensitive 
                 BL01206D 30.58 3.025e-28 363-412 
               
               
                   
                   
                 sodium channels proteins. 
                 BL01206G 21.72 6.063e-27 530-576 
               
               
                   
                   
                   
                 BL01206F 16.40 7.643e-15 485-506 
               
               
                   
                   
                   
                 BL01206E 20.72 5.650e-14 427-454 
               
               
                   
                   
                   
                 BL01206C 12.30 3.455e-12 333-352 
               
               
                   
                   
                   
                 BL01206B 13.56 1.205e-10 313-327 
               
               
                 460 
                 BL01220 
                 Phosphatidylethanolamine- 
                 BL01220B 16.65 1.000e-40 59-100 
               
               
                   
                   
                 binding protein 
                 BL01220C 14.75 5.846e-34 100-128 
               
               
                   
                   
                 family proteins. 
                 BL01220A 22.62 3.400e-31 21-52 
               
               
                 461 
                 BL00815 
                 Alpha-isopropylmalate and 
                 BL00815C 21.36 3.118e-09 786-815 
               
               
                   
                   
                 homocitrate synthases proteins. 
               
               
                 464 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 4.051e-09 1-16 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 470 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 5.200e-09 453-466 
               
               
                   
                   
                 METAL-BINDI. 
               
               
                 471 
                 BL00022 
                 EGF-like domain proteins. 
                 BL00022A 7.48 5.000e-09 177-184 
               
               
                   
                   
                   
                 BL00022A 7.48 5.000e-09 241-248 
               
               
                   
                   
                   
                 BL00022A 7.48 8.000e-09 49-56 
               
               
                 473 
                 PR00371 
                 FLAVOPROTEIN 
                 PR00371D 14.55 4.536e-11 385-405 
               
               
                   
                   
                 PYRIDINE NUCLEOTIDE 
               
               
                   
                   
                 CYTOCHROME REDUCTASE 
               
               
                   
                   
                 SIGNATURE 
               
               
                 474 
                 BL00028 
                 Zinc finger, C2H2 type, 
                 BL00028 16.07 4.462e-11 1087-1104 
               
               
                   
                   
                 domain proteins. 
               
               
                 475 
                 PR00260 
                 BACTERIAL CHEMOTAXIS 
                 PR00260C 10.26 9.294e-09 146-167 
               
               
                   
                   
                 SENSORY TRANSDUCER 
               
               
                   
                   
                 SIGNATURE 
               
               
                 476 
                 BL00845 
                 CAP-Gly domain proteins. 
                 BL00845 16.43 6.442e-21 405-430 
               
               
                   
                   
                   
                 BL00845 16.43 9.820e-19 203-228 
               
               
                 478 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 3.769e-15 369-382 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 4.462e-15 285-298 
               
               
                   
                   
                   
                 PD00066 13.92 2.800e-14 257-270 
               
               
                   
                   
                   
                 PD00066 13.92 5.200e-14 313-326 
               
               
                   
                   
                   
                 PD00066 13.92 8.962e-10 341-354 
               
               
                 481 
                 PR00671 
                 INHIBIN BETA B CHAIN 
                 PR00671C 4.18 5.345e-09 9-29 
               
               
                   
                   
                 SIGNATURE 
               
               
                 483 
                 DM01803 
                 1 HERPESVIRUS 
                 DM01803A 10.51 6.855e-09 215-236 
               
               
                   
                   
                 GLYCOPROTEIN H. 
               
               
                 484 
                 DM01803 
                 1 HERPESVIRUS 
                 DM01803A 10.51 6.855e-09 251-272 
               
               
                   
                   
                 GLYCOPROTEIN H. 
               
               
                 486 
                 PR00545 
                 RETINOIC ACID 
                 PR00545A 5.35 9.430e-09 383-398 
               
               
                   
                   
                 RECEPTOR SIGNATURE 
               
               
                 488 
                 BL01238 
                 GDA1/CD39 family of 
                 BL01238A 11.72 7.840e-16 76-91 
               
               
                   
                   
                 nucleoside phosphatases 
               
               
                   
                   
                 proteins. 
               
               
                 489 
                 PD00930 
                 PROTEIN GTPASE 
                 PD00930B 33.72 2.800e-26 1256-1297 
               
               
                   
                   
                 DOMAIN ACTIVATION. 
                 PD00930A 25.62 3.864e-13 1152-1178 
               
               
                 493 
                 BL00223 
                 Annexins repeat proteins 
                 BL00223B 28.47 1.000e-40 140-190 
               
               
                   
                   
                 domain proteins. 
                 BL00223C 24.79 1.000e-40 217-272 
               
               
                   
                   
                   
                 BL00223A 15.59 5.500e-32 21-55 
               
               
                   
                   
                   
                 BL00223A 15.59 4.783e-14 230-264 
               
               
                   
                   
                   
                 BL00223C 24.79 2.515e-10 8-63 
               
               
                   
                   
                   
                 BL00223A 15.59 6.250e-10 71-105 
               
               
                 496 
                 DM01513 
                 CAMP-DEPENDENT 
                 DM01513A 13.61 8.568e-14 15-56 
               
               
                   
                   
                 PROTEIN KINASE 
               
               
                   
                   
                 REGULATORY CHAIN. 
               
               
                 497 
                 BL00603 
                 Thymidine kinase 
                 BL00603C 30.02 1.000e-40 152-207 
               
               
                   
                   
                 cellular-type proteins. 
                 BL00603A 20.71 4.500e-33 63-96 
               
               
                   
                   
                   
                 BL00603D 10.53 5.091e-18 217-232 
               
               
                   
                   
                   
                 BL00603B 11.39 3.455e-15 132-147 
               
               
                 498 
                 PD01922 
                 PROTEIN 
                 PD01922B 21.83 7.328e-14 162-198 
               
               
                   
                   
                 PHOSPHODIESTERASE 
               
               
                   
                   
                 HYDROL. 
               
               
                 499 
                 BL00061 
                 Short-chain 
                 BL00061B 25.79 1.931e-13 99-137 
               
               
                   
                   
                 dehydrogenases/reductases 
               
               
                   
                   
                 family proteins. 
               
               
                 500 
                 BL01160 
                 Kinesin light chain 
                 BL01160B 19.54 5.958e-09 64-118 
               
               
                   
                   
                 repeat proteins. 
               
               
                 501 
                 PF00856 
                 SET domain proteins. 
                 PF00856A 26.14 8.579e-11 5-42 
               
               
                 504 
                 BL00030 
                 Eukaryotic RNA-binding region 
                 BL00030B 7.03 3.400e-10 116-126 
               
               
                   
                   
                 RNP-1 proteins. 
               
               
                 506 
                 PF00075 
                 RNase H. 
                 PF00075D 10.71 7.000e-11 517-528 
               
               
                   
                   
                   
                 PF00075C 11.58 9.786e-11 484-496 
               
               
                   
                   
                   
                 PF00075B 12.56 4.073e-10 449-460 
               
               
                   
                   
                   
                 PF00075A 14.44 2.143e-09 402-419 
               
               
                 508 
                 BL00262 
                 Insulin family proteins. 
                 BL00262B 16.89 8.286e-17 68-88 
               
               
                   
                   
                   
                 BL00262A 12.48 4.600e-15 32-50 
               
               
                 509 
                 PR00213 
                 MYELIN P0 PROTEIN 
                 PR00213E 5.51 9.775e-12 264-289 
               
               
                   
                   
                 SIGNATURE 
               
               
                 511 
                 BL00856 
                 Guanylate kinase proteins. 
                 BL00856C 29.21 2.658e-26 539-587 
               
               
                   
                   
                   
                 BL00856B 9.61 2.946e-18 511-532 
               
               
                 513 
                 PR00475 
                 HEXOKINASE FAMILY 
                 PR00475B 14.92 6.143e-26 186-212 
               
               
                   
                   
                 SIGNATURE 
                 PR00475E 16.08 2.742e-22 327-350 
               
               
                   
                   
                   
                 PR00475F 9.68 4.000e-20 407-430 
               
               
                   
                   
                   
                 PR00475A 14.06 3.118e-19 118-135 
               
               
                   
                   
                   
                 PR00475C 11.92 6.684e-19 239-256 
               
               
                   
                   
                   
                 PR00475G 9.08 1.692e-16 479-496 
               
               
                   
                   
                   
                 PR00475D 13.30 2.653e-13 262-277 
               
               
                   
                   
                   
                 PR00475G 9.08 2.650e-10 32-49 
               
               
                 516 
                 PR00722 
                 CHYMOTRYPSIN SERINE 
                 PR00722A 12.27 8.448e-14 56-72 
               
               
                   
                   
                 PROTEASE FAMILY (S1) 
               
               
                   
                   
                 SIGNATURE 
               
               
                 518 
                 BL00291 
                 Prion protein. 
                 BL00291A 4.49 9.379e-09 105-140 
               
               
                 519 
                 PF00534 
                 Glycosyl transferases 
                 PF00534B 14.47 9.581e-12 398-422 
               
               
                   
                   
                 group 1. 
               
               
                 520 
                 PF01105 
                 emp24/gp25L/p24 family. 
                 PF01105B 25.12 2.868e-25 126-178 
               
               
                 521 
                 PF01105 
                 emp24/gp25L/p24 family. 
                 PF01105B 25.12 2.868e-25 151-203 
               
               
                 522 
                 PR00305 
                 14-3-3 PROTEIN ZETA 
                 PR00305A 9.33 9.500e-36 37-67 
               
               
                   
                   
                 SIGNATURE 
                 PR00305E 13.01 4.316e-32 177-204 
               
               
                   
                   
                   
                 PR00305D 16.34 3.647e-30 150-177 
               
               
                   
                   
                   
                 PR00305F 15.95 1.964e-26 204-234 
               
               
                   
                   
                   
                 PR00305C 8.68 3.182e-26 115-138 
               
               
                   
                   
                   
                 PR00305B 9.99 4.857e-24 84-109 
               
               
                   
                   
                   
                 PR00305F 15.95 8.975e-15 215-245 
               
               
                 526 
                 PF00642 
                 Zinc finger C-x8-C-x5-C-x3-H 
                 PF00642 11.59 7.796e-10 676-687 
               
               
                   
                   
                 type (and similar). 
                 PF00642 11.59 7.055e-09 276-287 
               
               
                 527 
                 PF00588 
                 SpoU rRNA Methylase family. 
                 PF00588B 17.18 8.200e-10 281-303 
               
               
                 528 
                 BL01160 
                 Kinesin light chain 
                 BL01160B 19.54 5.653e-09 791-845 
               
               
                   
                   
                 repeat proteins. 
               
               
                 529 
                 PR00326 
                 GTP1/OBG GTP-BINDING 
                 PR00326A 8.75 4.255e-14 364-385 
               
               
                   
                   
                 PROTEIN FAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 531 
                 BL01305 
                 moaA/nifB/pqqE family 
                 BL01305D 14.97 7.279e-09 7-22 
               
               
                   
                   
                 proteins. 
               
               
                 532 
                 PR00918 
                 CALICIVIRUS NON- 
                 PR00915A 13.76 5.807e-09 458-479 
               
               
                   
                   
                 STRUCTURAL 
               
               
                   
                   
                 POLYPROTEIN FAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 533 
                 PR00171 
                 SUGAR TRANSPORTER 
                 PR00171E 14.87 1.000e-08 73-86 
               
               
                   
                   
                 SIGNATURE 
               
               
                 534 
                 DM01418 
                 352 FIBRILLAR 
                 DM01418A 20.83 5.650e-23 101-149 
               
               
                   
                   
                 COLLAGEN CARBOXYL- 
                 DM01418B 22.51 8.500e-11 166-208 
               
               
                   
                   
                 TERMINAL. 
                 DM01418C 20.48 8.655e-10 236-278 
               
               
                 535 
                 DM01418 
                 352 FIBRILLAR 
                 DM01418A 20.83 5.650e-23 117-165 
               
               
                   
                   
                 COLLAGEN CARBOXYL- 
                 DM01418B 22.51 8.500e-11 182-224 
               
               
                   
                   
                 TERMINAL. 
                 DM01418C 20.48 8.655e-10 252-294 
               
               
                 536 
                 BL01052 
                 Calponin family repeat 
                 BL01052B 15.31 3.308e-11 30-56 
               
               
                   
                   
                 proteins. 
               
               
                 538 
                 BL00795 
                 Involucrin proteins. 
                 BL00795C 17.06 7.600e-09 239-284 
               
               
                 542 
                 BL01046 
                 ATP-dependent serine 
                 BL01046D 19.61 4.938e-35 452-493 
               
               
                   
                   
                 proteases, lon family, 
                 BL01046C 17.03 9.581e-31 377-421 
               
               
                   
                   
                 serine active sit. 
                 BL01046B 19.24 4.977e-29 331-377 
               
               
                 543 
                 BL00824 
                 Elongation factor 1 
                 BL00824B 9.21 2.338e-09 150-170 
               
               
                   
                   
                 beta/beta′/delta 
               
               
                   
                   
                 chain proteins. 
               
               
                 547 
                 BL00615 
                 C-type lectin domain proteins. 
                 BL00615A 16.68 3.880e-11 47-65 
               
               
                   
                   
                   
                 BL00615B 12.25 2.286e-10 149-163 
               
               
                 550 
                 PR00119 
                 P-TYPE CATION- 
                 PR00119B 13.94 8.714e-12 35-50 
               
               
                   
                   
                 TRANSPORTING ATPASE 
                 PR00119E 8.48 7.716e-11 420-440 
               
               
                   
                   
                 SUPERFAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 551 
                 BL00039 
                 DEAD-box subfamily 
                 BL00039D 21.67 3.455e-33 476-522 
               
               
                   
                   
                 ATP-dependent 
                 BL00039A 18.44 8.548e-23 145-184 
               
               
                   
                   
                 helicases proteins. 
                 BL00039C 15.63 8.500e-16 277-301 
               
               
                   
                   
                   
                 BL00039B 19.19 1.837e-12 191-217 
               
               
                 553 
                 BL00115 
                 Eukaryotic RNA polymerase II 
                 BL00115Z 3.12 9.669e-09 116-165 
               
               
                   
                   
                 heptapeptide repeat proteins. 
               
               
                 554 
                 PF00168 
                 C2 domain proteins. 
                 PF00168B 11.83 8.000e-10 38-49 
               
               
                 555 
                 PP00791 
                 Domain present in 
                 PF00791B 28.49 4.165e-13 780-835 
               
               
                   
                   
                 ZO-1 and Unc5-like 
                 PF00791B 28.49 6.767e-10 888-943 
               
               
                   
                   
                 netrin receptors. 
                 PF00791C 20.98 8.059e-09 794-833 
               
               
                 556 
                 PF00023 
                 Ank repeat proteins. 
                 PF00023A 16.03 5.875e-10 437-453 
               
               
                   
                   
                   
                 PF00023A 16.03 7.000e-10 563-579 
               
               
                   
                   
                   
                 PF00023A 16.03 8.500e-10 248-264 
               
               
                   
                   
                   
                 PF00023A 16.03 9.250e-10 95-111 
               
               
                   
                   
                   
                 PF00023A 16.03 3.250e-09 596-612 
               
               
                   
                   
                   
                 PF00023A 16.03 3.893e-09 716-732 
               
               
                   
                   
                   
                 PF00023A 16.03 6.786e-09 62-78 
               
               
                   
                   
                   
                 PF00023A 16.03 9.036e-09 496-512 
               
               
                 557 
                 BL00479 
                 Phorbol esters/diacylglycerol 
                 BL00479B 12.57 8.714e-09 143-159 
               
               
                   
                   
                 binding domain proteins. 
               
               
                 558 
                 BL00479 
                 Phorbol esters/diacylglycerol 
                 BL00479B 12.57 8.714e-09 167-183 
               
               
                   
                   
                 binding domain proteins. 
               
               
                 559 
                 BL00518 
                 Zinc finger, C3HC4 type 
                 BL00518 12.23 5.286e-10 239-248 
               
               
                   
                   
                 (RING finger) proteins. 
               
               
                 562 
                 BL00122 
                 Carboxylesterases type-B 
                 BL00122G 11.67 2.500e-15 15-26 
               
               
                   
                   
                 serine proteins. 
               
               
                 563 
                 PR00910 
                 LUTEOVIRUS ORF6 
                 PR00910A 2.51 1.986e-11 340-353 
               
               
                   
                   
                 PROTEIN SIGNATURE 
                 PR00910A 2.51 1.986e-11 342-355 
               
               
                   
                   
                   
                 PR00910A 2.51 1.986e-11 344-357 
               
               
                   
                   
                   
                 PR00910A 2.51 9.778e-10 346-359 
               
               
                   
                   
                   
                 PR00910A 2.51 1.107e-09 338-351 
               
               
                   
                   
                   
                 PR00910A 2.51 3.464e-09 336-349 
               
               
                 564 
                 DM01970 
                 0 kw ZK632.12 
                 DM01970B 8.60 8.475e-15 175-188 
               
               
                   
                   
                 YDR313C ENDOSOMAL III. 
               
               
                 566 
                 PR00833 
                 POLLEN ALLERGEN POA 
                 PR00833H 2.30 8.375e-10 149-164 
               
               
                   
                   
                 PI SIGNATURE 
                 PR00833H 2.30 2.846e-09 147-162 
               
               
                 567 
                 PF00992 
                 Troponin. 
                 PF00992A 16.67 3.368e-09 448-483 
               
               
                 573 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019A 11.19 7.333e-09 322-336 
               
               
                   
                   
                 SIGNATURE 
                 PR00019B 11.36 9.280e-09 319-333 
               
               
                 574 
                 BL00315 
                 Dehydrins proteins. 
                 BL00315A 9.35 7.197e-10 93-121 
               
               
                 576 
                 PD00930 
                 PROTEIN GTPASE 
                 PD00930B 33.72 4.240e-16 235-276 
               
               
                   
                   
                 DOMAIN ACTIVATION. 
               
               
                 577 
                 BL00183 
                 Ubiquitin-conjugating 
                 BL00183 28.97 8.338e-14 44-92 
               
               
                   
                   
                 enzymes proteins. 
               
               
                 579 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019B 11.36 6.850e-10 132-146 
               
               
                   
                   
                 SIGNATURE 
                 PR00019A 11.19 2.667e-09 135-149 
               
               
                   
                   
                   
                 PR00019B 11.36 9.640e-09 180-194 
               
               
                   
                   
                   
                 PR00019B 11.36 1.000e-08 277-291 
               
               
                 581 
                 BL00625 
                 Regulator of chromosome 
                 BL00625A 16.21 2.033e-16 567-596 
               
               
                   
                   
                 condensation (RCC1) 
                 BL00625B 17.69 4.205e-12 561-595 
               
               
                   
                   
                 proteins. 
                 BL00625R 17.69 9.423e-11 93-127 
               
               
                   
                   
                   
                 BL00625B 17.69 1.444e-10 152-186 
               
               
                   
                   
                   
                 BL00625A 16.21 1.759e-10 99-128 
               
               
                   
                   
                   
                 BL00625A 16.21 2.739e-09 515-544 
               
               
                   
                   
                   
                 BL00625B 17.69 3.172e-09 43-77 
               
               
                   
                   
                   
                 BL00625A 16.21 4.170e-09 158-187 
               
               
                 582 
                 BL00414 
                 Profilin proteins. 
                 BL00414A 13.85 6.344e-13 2-16 
               
               
                   
                   
                   
                 BL00414E 15.46 6.283e-09 121-136 
               
               
                 583 
                 BL00414 
                 Profilin proteins. 
                 BL00414A 13.85 6.344e-13 2-16 
               
               
                   
                   
                   
                 BL00414E 15.46 6.283e-09 105-120 
               
               
                 584 
                 PD00301 
                 PROTEIN REPEAT 
                 PD00301A 10.24 8.200e-09 131-142 
               
               
                   
                   
                 MUSCLE CALCIUM-BI. 
               
               
                 585 
                 DM01930 
                 2 kw FINGER SMCX 
                 DM01930F 14.16 1.310e-27 24-60 
               
               
                   
                   
                 SMCY YDR096W. 
               
               
                 586 
                 BL00411 
                 Kinesin motor domain proteins. 
                 BL00411G 21.39 2.200e-39 77-119 
               
               
                   
                   
                   
                 BL00411H 15.66 8.800e-33 125-156 
               
               
                   
                   
                   
                 BL00411F 14.77 6.250e-18 33-58 
               
               
                 588 
                 BL00600 
                 Aminotransferases class-III 
                 BL00600E 16.43 5.725e-15 164-193 
               
               
                   
                   
                 pyridoxal-phosphate 
                 BL00600G 12.43 7.000e-14 242-261 
               
               
                   
                   
                 attachment si. 
                 BL00600F 8.77 7.480e-11 207-220 
               
               
                   
                   
                   
                 BL00600D 8.71 1.750e-10 143-157 
               
               
                 589 
                 BL00838 
                 Interleukins −4 and −13 
                 BL00838A 12.35 8.696e-09 136-155 
               
               
                   
                   
                 proteins. 
               
               
                 591 
                 PR00121 
                 SODIUM/POTASSIUM- 
                 PR00121D 16.72 3.012e-12 261-283 
               
               
                   
                   
                 TRANSPORTING ATPASE 
               
               
                   
                   
                 SIGNATURE 
               
               
                 592 
                 BL00289 
                 Pentaxin family proteins. 
                 BL00289A 30.36 9.03le-09 331-362 
               
               
                 594 
                 BL01279 
                 Protein-L-isoaspartate 
                 BL01279A 24.27 1.000e-11 67-115 
               
               
                   
                   
                 (D-aspartate) 
               
               
                   
                   
                 O-methyltransferase signa. 
               
               
                 597 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 4.462e-32 244-287 
               
               
                 598 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 6.400e-16 245-258 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 8.615e-15 329-342 
               
               
                   
                   
                   
                 PD00066 13.92 6.000e-13 301-314 
               
               
                   
                   
                   
                 PD00066 13.92 4.857e-12 217-230 
               
               
                   
                   
                   
                 PD00066 13.92 1.346e-10 273-286 
               
               
                   
                   
                   
                 PD00066 13.92 8.200e-09 357-370 
               
               
                 599 
                 BL00585 
                 Ribosomal protein S5 proteins. 
                 BL00585B 18.78 6.143e-18 303-340 
               
               
                   
                   
                   
                 BL00585A 28.43 4.286e-16 220-272 
               
               
                 600 
                 PR00482 
                 OMPTIN SERINE 
                 PR00482C 11.02 7.968e-09 816-842 
               
               
                   
                   
                 PROTEASE SIGNATURE 
               
               
                 601 
                 PR00500 
                 POLYCYSTIC KIDNEY 
                 PR00500B 7.74 7.359e-10 56-77 
               
               
                   
                   
                 DISEASE PROTEIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 603 
                 PR00917 
                 SMALL ROUND 
                 PR00917G 10.59 8.990e-09 812-830 
               
               
                   
                   
                 STRUCTURED VIRUS 
               
               
                   
                   
                 (C37) CYSTEINE 
               
               
                   
                   
                 PROTEASE FAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 605 
                 BL00028 
                 Zinc finger, C2H2 type, 
                 BL00028 16.07 9.486e-09 109-126 
               
               
                   
                   
                 domain proteins. 
               
               
                 607 
                 PF00638 
                 RanBP1 domain proteins. 
                 PR00638 11.91 4.600e-18 67-82 
               
               
                 608 
                 BL00406 
                 Actins proteins. 
                 BL00406E 8.44 8.541e-28 323-373 
               
               
                   
                   
                   
                 BL00406B 5.47 1.375e-27 82-137 
               
               
                   
                   
                   
                 BL00406D 12.58 3.160e-26 266-321 
               
               
                   
                   
                   
                 BL00406C 6.75 6.943e-25 141-196 
               
               
                   
                   
                   
                 BL00406A 9.95 2.575e-20 7-42 
               
               
                 610 
                 BL00048 
                 Protamine P1 proteins. 
                 BL0004B 6.39 3.700e-09 153-180 
               
               
                 611 
                 PR00315 
                 GTP-BINDING 
                 PR00315A 11.81 5.688e-10 126-140 
               
               
                   
                   
                 ELONGATION FACTOR 
               
               
                   
                   
                 SIGNATURE 
               
               
                 615 
                 PF00780 
                 Domain found in NIK1-like 
                 PR00780B 23.03 9.908e-09 14-57 
               
               
                   
                   
                 kinases, mouse citron and 
               
               
                   
                   
                 yeast ROM. 
               
               
                 619 
                 BL00162 
                 Eukaryotic-type 
                 BL00162C 17.78 1.000e-40 88-125 
               
               
                   
                   
                 carbonic anhydrases 
                 BL00162E 14.93 7.231e-39 171-204 
               
               
                   
                   
                 proteins. 
                 BL00162F 22.68 5.050e-31 208-242 
               
               
                   
                   
                   
                 BL00162A 22.92 8.714e-30 16-47 
               
               
                   
                   
                   
                 BL00162D 15.06 7.158e-24 126-151 
               
               
                   
                   
                   
                 BL00162B 21.43 1.375e-19 51-74 
               
               
                 620 
                 PR00457 
                 ANIMAL HAEM 
                 PR00457E 20.67 1.621e-24 414-441 
               
               
                   
                   
                 PEROXIDASE SIGNATURE 
                 PR00457D 16.81 8.258e-21 389-410 
               
               
                   
                   
                   
                 PR00457B 13.29 3.455e-18 223-239 
               
               
                   
                   
                   
                 PR00457G 17.45 7.000e-18 595-616 
               
               
                   
                   
                   
                 PR00457C 19.25 4.414e-16 371-390 
               
               
                   
                   
                   
                 PR00457H 15.90 8.650e-14 666-681 
               
               
                   
                   
                   
                 PR00457A 15.80 5.645e-12 169-181 
               
               
                   
                   
                   
                 PR00457F 13.69 8.875e-11 467-478 
               
               
                 621 
                 BL01304 
                 ubiH/COQ6 monooxygenase 
                 BL01304A 8.05 3.571e-11 50-64 
               
               
                   
                   
                 family proteins. 
               
               
                 623 
                 BL00019 
                 Actinin-type actin-binding 
                 BL00019D 15.33 3.880e-17 145-175 
               
               
                   
                   
                 domain proteins. 
               
               
                 625 
                 BL00893 
                 mutT domain proteins. 
                 BL00893 18.99 5.500e-16 127-152 
               
               
                 626 
                 PF00632 
                 HECT-domain 
                 PF00632B 18.45 7.000e-16 488-516 
               
               
                   
                   
                 (ubiquitin-transferase). 
                 PF00632C 20.66 7.851e-14 533-565 
               
               
                 628 
                 PR00239 
                 MOLLUSCAN RHODOPSIN 
                 PR00239E 1.58 9.566e-10 292-304 
               
               
                   
                   
                 C-TERMINAL TAIL 
               
               
                   
                   
                 SIGNATURE 
               
               
                 634 
                 BL01280 
                 Glucose inhibited division 
                 BL01280A 15.97 6.727e-36 69-110 
               
               
                   
                   
                 protein A family proteins. 
                 BL01280B 23.56 8.105e-27 128-180 
               
               
                 638 
                 PR00413 
                 HALOACID 
                 PR00413E 15.78 6.714e-09 70-87 
               
               
                   
                   
                 DEHALOGENASE/EPOXIDE 
               
               
                   
                   
                 HYDROLASE FAMILY 
               
               
                   
                   
                 SIGNATURE 
               
               
                 639 
                 PD01861 
                 PROTEIN NUCLEAR 
                 PD01861A 14.06 6.318e-10 60-84 
               
               
                   
                   
                 RIBONUCLEOPROTEIN 
               
               
                   
                   
                 SMALL MRNA RNA. 
               
               
                 640 
                 PD00289 
                 PROTEIN SH3 DOMAIN 
                 PD00289 9.97 6.586e-09 46-60 
               
               
                   
                   
                 REPEAT PRESYNA. 
               
               
                 643 
                 BL00914 
                 Syntaxin/ 
                 BL00914 24.91 1.250e-29 184-234 
               
               
                   
                   
                 epimorphin family proteins. 
               
               
                 644 
                 PR00010 
                 TYPE II EGF-LIKE 
                 PR00010C 11.16 6.667e-11 363-374 
               
               
                   
                   
                 SIGNATURE 
               
               
                 645 
                 PR00625 
                 DNAJ PROTEIN FAMILY 
                 PR00625A 12.84 4.600e-20 14-34 
               
               
                   
                   
                 SIGNATURE 
                 PR00625B 13.48 8.759e-20 46-67 
               
               
                 646 
                 PD02448 
                 TRANSCRIPTION 
                 PD02448A 9.37 3.854e-09 351-390 
               
               
                   
                   
                 PROTEIN DNA-BINDIN. 
               
               
                 650 
                 PD02446 
                 TRANSCRIPTION 
                 PD02448A 9.37 1.511e-20 50-89 
               
               
                   
                   
                 PROTEIN DNA-BINDIN. 
                 PD02448B 10.17 8.071e-19 89-137 
               
               
                 654 
                 PR00403 
                 WW DOMAIN SIGNATURE 
                 PR00403B 12.19 9.816e-11 144-159 
               
               
                   
                   
                   
                 PR00403B 12.19 8.167e-10 103-118 
               
               
                 655 
                 PR00403 
                 WW DOMAIN SIGNATURE 
                 PR00403B 12.19 9.816e-11 107-122 
               
               
                 657 
                 PR00929 
                 AT-HOOK-LIKE DOMAIN 
                 PR00929B 4.38 4.600e-10 358-370 
               
               
                   
                   
                 SIGNATURE 
               
               
                 658 
                 PD02379 
                 AMINOTRANSFERASE 
                 PD02379E 11.43 1.000e-40 194-236 
               
               
                   
                   
                 BIOSYNTHESIS 
                 PD02379F 18.62 6.029e-35 245-284 
               
               
                   
                   
                 PHOSPHOSERINE SER. 
                 PD02379H 16.03 5.235e-33 352-385 
               
               
                   
                   
                   
                 PD02379B 12.05 3.613e-31 80-113 
               
               
                   
                   
                   
                 PD02379A 15.57 2.800e-25 29-60 
               
               
                   
                   
                   
                 PD023790 13.34 3.700e-21 119-139 
               
               
                   
                   
                   
                 PD02379D 11.83 9.419e-16 168-181 
               
               
                   
                   
                   
                 PD02379G 10.62 2.537e-14 313-328 
               
               
                 659 
                 PD02379 
                 AMINOTRANSFERASE 
                 PD02379E 11.43 1.000e-40 194-236 
               
               
                   
                   
                 BIOSYNTHESIS 
                 PD02379F 18.62 6.029e-35 245-284 
               
               
                   
                   
                 PHOSPHOSERINE SER. 
                 PD02379B 12.05 3.613e-31 80-113 
               
               
                   
                   
                   
                 PD02379A 15.57 2.800e-25 29-60 
               
               
                   
                   
                   
                 PD02379H 16.03 7.864e-23 306-339 
               
               
                   
                   
                   
                 PD023790 13.34 3.700e-21 119-139 
               
               
                   
                   
                   
                 PD02379D 11.83 9.419e-16 168-181 
               
               
                 662 
                 PR00874 
                 FUNGI-IV 
                 PR00874C 4.37 6.625e-09 33-48 
               
               
                   
                   
                 METALLOTHIONEIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 666 
                 BL00035 
                 ′POU′ domain proteins. 
                 BL00035B 14.46 6.236e-09 683-704 
               
               
                 668 
                 PF00168 
                 C2 domain proteins. 
                 PF00168C 27.49 8.412e-13 634-660 
               
               
                 669 
                 PR00168 
                 C2 domain proteins. 
                 PR00168C 27.49 8.412e-13 115-141 
               
               
                 671 
                 PR00566 
                 DOPAMINE 1B RECEPTOR 
                 PR00566E 13.44 5.255e-18 466-483 
               
               
                   
                   
                 SIGNATURE 
                 PR00566A 9.32 3.000e-17 200-214 
               
               
                   
                   
                   
                 PR00566D 9.35 1.600e-12 446-455 
               
               
                   
                   
                   
                 PR00566C 11.44 2.184e-12 401-412 
               
               
                   
                   
                   
                 PR00566B 8.20 3.053e-11 341-351 
               
               
                 672 
                 PR00169 
                 POTASSIUN CHANNEL 
                 PR00169A 16.77 7.851e-11 46-66 
               
               
                   
                   
                 SIGNATURE 
               
               
                 673 
                 DM00215 
                 PROLINE-RICH PROTEIN 3. 
                 DM00215 19.43 7.529e-11 183-216 
               
               
                 674 
                 BL00951 
                 ER lumen protein retaining 
                 BL00951B 14.23 1.670e-09 43-74 
               
               
                   
                   
                 receptor proteins. 
               
               
                 675 
                 BL00292 
                 Cyclins proteins. 
                 BL00292B 20.31 3.925e-11 120-151 
               
               
                 676 
                 PR00048 
                 C2H2-TYPE ZINC 
                 PR00048A 10.52 3.160e-09 111-125 
               
               
                   
                   
                 FINGER SIGNATURE 
               
               
                 677 
                 BL01226 
                 Hydroxymethylglutary 
                 BL01226I 25.06 8.560e-09 256-304 
               
               
                   
                   
                 1-coenzyme A 
               
               
                   
                   
                 synthase proteins. 
               
               
                 681 
                 BL00030 
                 Eukaryotic RNA-binding region 
                 BL00030A 14.39 1.563e-12 72-91 
               
               
                   
                   
                 RNP-1 proteins. 
                 BL00030A 14.39 2.125e-12 156-175 
               
               
                 689 
                 BL00740 
                 MAM domain proteins. 
                 BL00740B 19.76 3.813e-09 637-658 
               
               
                 693 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 7.000e-11 93-136 
               
               
                 698 
                 PR00259 
                 TRANSMEMBRANE FOUR 
                 PR00259A 9.27 3.308e-18 19-43 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00259C 16.40 9.800e-18 88-117 
               
               
                   
                   
                   
                 PR00259D 13.50 2.756e-15 238-265 
               
               
                 703 
                 PR00669 
                 INHIBIN ALPHA CHAIN 
                 PR00669F 5.57 9.899e-09 223-241 
               
               
                   
                   
                 SIGNATURE 
               
               
                 704 
                 DM01292 
                 ESICULAR LUMEN 
                 DM01292L 12.54 9.505e-09 240-265 
               
               
                   
                   
                 DOMAIN. 
               
               
                 705 
                 PR00128 
                 COLIPASE SIGNATURE 
                 PR00128D 9.77 6.250e-25 47-66 
               
               
                   
                   
                   
                 PR00128C 9.28 5.299e-20 24-47 
               
               
                 708 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 9.929e-10 384-399 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 710 
                 BL01118 
                 Translation initiation 
                 BL01118B 26.75 8.579e-26 94-132 
               
               
                   
                   
                 factor SUI1 proteins. 
                 BL01118A 12.46 4.000e-13 77-92 
               
               
                 711 
                 BL00811 
                 Oleosins proteins. 
                 BL00811A 8.26 3.310e-09 120-158 
               
               
                 712 
                 BL00674 
                 AAA-protein family proteins. 
                 BL00674B 4.46 9.182e-11 184-206 
               
               
                 713 
                 DM01871 
                 kw SSR LIGASE 
                 DM018710 20.79 9.836e-10 270-296 
               
               
                   
                   
                 CYCLOFORMYL- 
               
               
                   
                   
                 TETRAHYDROFOLATE. 
               
               
                 715 
                 PR00049 
                 WILM&#39;S TUMOUR 
                 PR00049D 0.00 7.712e-09 95-110 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 717 
                 BL01181 
                 Ribosomal protein 
                 BL01181 15.43 2.500e-10 13-49 
               
               
                   
                   
                 S21 proteins. 
               
               
                 718 
                 PR00259 
                 TRANSMEMBRANE FOUR 
                 PR002590 16.40 6.824e-16 88-117 
               
               
                   
                   
                 FAMILY SIGNATURE 
                 PR00259A 9.27 3.423e-14 24-48 
               
               
                   
                   
                   
                 PR00259D 13.50 1.574e-13 238-265 
               
               
                   
                   
                   
                 PR00259B 14.81 8.714e-13 61-88 
               
               
                 720 
                 PR00496 
                 NAPIN SIGNATURE 
                 PR00496A 6.68 6.276e-09 21-43 
               
               
                 723 
                 PR00237 
                 RHODOPSIN-LIKE GPCR 
                 PR00237G 19.63 2.543e-11 670-697 
               
               
                   
                   
                 SUPERFAMILY 
                 PR00237A 11.48 3.000e-10 424-449 
               
               
                   
                   
                 SIGNATURE 
               
               
                 724 
                 BL00972 
                 Ubiquitin carboxyl-terminal 
                 BL00972A 11.93 7.500e-20 36-54 
               
               
                   
                   
                 terminal hydrolases 
                 BL00972D 22.55 6.806e-16 296-321 
               
               
                   
                   
                 family 2 proteins. 
                 BL00972B 9.45 1.000e-13 116-126 
               
               
                   
                   
                   
                 BL00972E 20.72 8.773e-12 321-343 
               
               
                 725 
                 PF00646 
                 F-box domain proteins. 
                 PF00646A 14.37 6.906e-09 92-106 
               
               
                 727 
                 BL00933 
                 FGGY family of 
                 BL00933D 24.01 7.545e-15 212-249 
               
               
                   
                   
                 carbohydrate kinases 
                 BL00933B 15.94 2.200e-09 54-65 
               
               
                   
                   
                 proteins. 
                 BL00933E 13.80 3.543e-09 439-455 
               
               
                   
                   
                   
                 BL00933A 17.50 4.857e-09 20-44 
               
               
                 728 
                 PR00876 
                 NEMATODE 
                 PR00876B 7.66 1.887e-10 137-151 
               
               
                   
                   
                 METALLOTHIONEIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 731 
                 PD01976 
                 KINASE DEHYDROGENASE 
                 PD01976A 8.95 1.493e-09 83-96 
               
               
                   
                   
                 TRANSFERASE. 
               
               
                 732 
                 BL00623 
                 GMC oxidoreductases proteins. 
                 BL00623A 12.60 9.859e-10 12-31 
               
               
                 735 
                 BL01172 
                 Ribosomal protein 
                 BL01172B 14.10 8.909e-38 15-57 
               
               
                   
                   
                 L44e proteins. 
                 BL01172C 16.78 7.188e-31 63-102 
               
               
                 737 
                 DM01724 
                 kw ALLERGEN POLLEN 
                 DM01724 8.14 5.909e-11 11-31 
               
               
                   
                   
                 CIM1 HOL-LI. 
                 DM01724 8.14 6.591e-11 41-61 
               
               
                   
                   
                   
                 DM01724 8.14 6.831e-10 39-59 
               
               
                   
                   
                   
                 DM01724 8.14 8.697e-09 55-75 
               
               
                 738 
                 PR00320 
                 G-PROTEIN BETA WD-40 
                 PR00320A 16.74 8.463e-09 73-88 
               
               
                   
                   
                 REPEAT SIGNATURE 
               
               
                 742 
                 PD02269 
                 CYTIDINE DEAMINASE 
                 PD022690 16.36 7.882e-17 79-92 
               
               
                   
                   
                 HYDROLASE ZINC 
                 PD02269A 10.06 1.000e-15 29-41 
               
               
                   
                   
                 AMINOHY. 
                 PD02269D 11.98 5.000e-14 110-125 
               
               
                 743 
                 BL00790 
                 Receptor tyrosine 
                 BL00790D 12.41 8.297e-09 429-454 
               
               
                   
                   
                 kinase class V proteins. 
               
               
                 744 
                 BL00750 
                 Chaperonins TCP-1 proteins. 
                 BL00750B 16.17 2.000e-39 69-119 
               
               
                   
                   
                   
                 BL00750A 20.07 8.286e-36 25-68 
               
               
                   
                   
                   
                 BL00750C 25.65 8.579e-23 152-184 
               
               
                 746 
                 BL00415 
                 Synapsins proteins. 
                 BL00415N 4.29 4.710e-10 225-269 
               
               
                 748 
                 BL00028 
                 Zinc finger, C2H2 type 
                 BL00028 16.07 1.000e-09 212-229 
               
               
                   
                   
                 domain proteins. 
                 BL00028 16.07 6.143e-09 365-382 
               
               
                 752 
                 BL00030 
                 Eukaryotic RNA-binding region 
                 BL00030A 14.39 6.143e-13 332-351 
               
               
                   
                   
                 RNP-1 proteins. 
               
               
                 753 
                 PF00023 
                 Ank repeat proteins. 
                 PR00023A 16.03 8.500e-10 283-299 
               
               
                   
                   
                   
                 PF00023A 16.03 9.625e-10 347-363 
               
               
                   
                   
                   
                 PF00023A 16.03 1.321e-09 184-200 
               
               
                   
                   
                   
                 PF00023A 16.03 1.643e-09 150-166 
               
               
                 754 
                 BL00107 
                 Protein kinases ATP-binding 
                 BL00107B 13.31 1.643e-10 202-218 
               
               
                   
                   
                 region proteins. 
               
               
                 760 
                 PR00671 
                 INHIBIN BETA B CHAIN 
                 PR006710 4.18 8.966e-09 212-232 
               
               
                   
                   
                 SIGNATURE 
               
               
                 761 
                 PR00678 
                 P13 KINASE P85 
                 PR00678H 9.13 7.805e-12 292-315 
               
               
                   
                   
                 REGULATORY SUBUNIT 
               
               
                   
                   
                 SIGNATURE 
               
               
                 762 
                 PR00412 
                 EPOXIDE HYDROLASE 
                 PR00412C 11.30 2.421e-12 169-183 
               
               
                   
                   
                 SIGNATURE 
                 PR00412A 13.23 7.947e-12 104-123 
               
               
                   
                   
                   
                 PR00412B 12.59 7.429e-10 123-139 
               
               
                 763 
                 PR00217 
                 43 KD POSTSYNAPTIC 
                 PR00217C 10.91 7.247e-10 293-309 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 764 
                 PR00320 
                 G-PROTEIN BETA WD-40 
                 PR00320A 16.74 9.122e-09 277-292 
               
               
                   
                   
                 REPEAT SIGNATURE 
                 PR00320A 16.74 9.780e-09 233-248 
               
               
                   
                   
                   
                 PR00320C 13.01 1.000e-08 233-248 
               
               
                 765 
                 BL01230 
                 RNA methyltransferase 
                 BL01230E 15.79 2.918e-11 487-503 
               
               
                   
                   
                 trmA family proteins. 
               
               
                 771 
                 BL00039 
                 DEAD-box subfamily 
                 BL00039D 21.67 2.957e-09 434-480 
               
               
                   
                   
                 ATP-dependent 
               
               
                   
                   
                 helicases proteins. 
               
               
                 773 
                 PR00453 
                 VON WILLEBRAND 
                 PR00453A 12.79 2.957e-10 33-51 
               
               
                   
                   
                 FACTOR TYPE A DOMAIN 
               
               
                   
                   
                 SIGNATURE 
               
               
                 777 
                 PR00493 
                 BREAST CANCER TYPE I 
                 PR00493G 7.57 3.711e-14 693-714 
               
               
                   
                   
                 SUSCEPTIBILITY 
               
               
                   
                   
                 PROTEIN SIGNATURE 
               
               
                 778 
                 BL00443 
                 Glutamine amidotransferases 
                 BL00443F 16.68 8.714e-09 85-101 
               
               
                   
                   
                 class-II proteins. 
               
               
                 780 
                 DM01206 
                 CORONAVIRUS 
                 DM01206B 10.69 7.288e-10 167-187 
               
               
                   
                   
                 NUCLEOCAPSID 
               
               
                   
                   
                 PROTEIN. 
               
               
                 783 
                 BL01221 
                 PMP-22/EMP/MP20 
                 BL012210 26.20 1.281e-34 59-104 
               
               
                   
                   
                 family proteins. 
                 BL01221D 13.99 5.966e-27 136-163 
               
               
                   
                   
                   
                 BL01221A 17.26 2.385e-26 1-29 
               
               
                   
                   
                   
                 BL01221B 13.29 1.000e-14 38-52 
               
               
                 785 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 4.000e-10 297-340 
               
               
                 786 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 4.000e-10 297-340 
               
               
                 790 
                 BL00303 
                 S-100/ICaBP type calcium 
                 BL00303B 26.15 5.075e-13 73-110 
               
               
                   
                   
                 binding protein. 
               
               
                 792 
                 PD01941 
                 TRANSMEMBRANE 
                 PD01941C 19.96 4.960e-16 84-139 
               
               
                   
                   
                 COTRANSPORTER SYMP. 
                 PD01941B 15.02 2.093e-11 4-51 
               
               
                 794 
                 BL00672 
                 Serine proteases, V8 family 
                 BL00672B 9.84 3.554e-09 214-231 
               
               
                   
                   
                 histidine proteins. 
               
               
                 797 
                 BL00674 
                 AAA-protein family proteins. 
                 BL00674B 4.46 7.814e-10 360-382 
               
               
                 798 
                 BL00674 
                 AAA-protein family proteins. 
                 BL00674B 4.46 7.814e-10 360-382 
               
               
                 799 
                 BL00215 
                 Mitochondrial energy 
                 BL00215A 15.82 9.591e-16 206-231 
               
               
                   
                   
                 transfer proteins. 
                 BL00215A 15.82 4.000e-15 104-129 
               
               
                   
                   
                   
                 BL00215A 15.82 9.400e-15 7-32 
               
               
                   
                   
                   
                 BL00215B 10.44 1.000e-10 154-167 
               
               
                 801 
                 BL01013 
                 Oxysterol-binding protein 
                 BL01013A 25.14 5.500e-21 537-573 
               
               
                   
                   
                 family proteins. 
                 BL01013D 26.81 2.16le-18 807-851 
               
               
                   
                   
                   
                 BL01013C 9.97 4.231e-13 625-635 
               
               
                   
                   
                   
                 BL01013B 11.33 3.017e-11 603-614 
               
               
                 803 
                 BL00711 
                 Lipoxygenases iron-binding 
                 BL00711I 18.56 8.630e-28 577-615 
               
               
                   
                   
                 binding region proteins. 
                 BL00711E 19.66 3.550e-22 414-451 
               
               
                   
                   
                   
                 BL00711G 21.83 9.100e-22 503-535 
               
               
                   
                   
                   
                 BL00711C 20.75 5.959e-19 268-297 
               
               
                   
                   
                   
                 BL00711D 17.56 1.923e-16 347-373 
               
               
                   
                   
                   
                 BL00711H 23.34 1.771e-12 535-574 
               
               
                   
                   
                   
                 BL00711F 19.79 2.086e-10 484-501 
               
               
                 805 
                 PR00492 
                 RHO PROTEIN GDP 
                 PR00492C 9.68 1.900e-23 122-139 
               
               
                   
                   
                 DISSOCIATION 
                 PR00492B 9.77 8.579e-23 76-95 
               
               
                   
                   
                 INHIBITOR SIGNATURE 
                 PR004920 14.82 8.200e-21 139-155 
               
               
                   
                   
                   
                 PR00492A 11.92 1.643e-18 60-76 
               
               
                 808 
                 BL00378 
                 Hexokinases proteins. 
                 BL00378A 19.01 8.500e-09 403-431 
               
               
                 809 
                 BL00027 
                 ′Homeobox′ domain proteins. 
                 BL00027 26.43 8.615e-33 35-78 
               
               
                 810 
                 PR00179 
                 LIPOCALIN SIGNATURE 
                 PR00179B 9.56 1.000e-12 102-115 
               
               
                   
                   
                   
                 PR001790 19.02 1.000e-10 130-146 
               
               
                   
                   
                   
                 PR00179A 13.78 5.680e-10 37-50 
               
               
                 811 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 1.818e-11 164-187 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 814 
                 BL00269 
                 Mammalian defensins proteins. 
                 BL002690 16.52 7.158e-09 171-200 
               
               
                 815 
                 BL00216 
                 Sugar transport proteins. 
                 BL00216B 27.64 5.846e-09 141-191 
               
               
                 818 
                 BL00456 
                 Sodium:solute symporter 
                 BL00456A 22.59 2.080e-30 83-138 
               
               
                   
                   
                 family proteins. 
                 BL00456C 24.55 3.721e-29 221-276 
               
               
                   
                   
                   
                 BL00456B 18.94 1.000e-22 159-189 
               
               
                 819 
                 BL00142 
                 Neutral zinc metallopeptidases, 
                 BL00142 8.38 1.857e-09 494-505 
               
               
                   
                   
                 zinc-binding region proteins. 
               
               
                 820 
                 BL00509 
                 Ras GTPase-activating 
                 BL00509B 10.28 1.643e-12 610-621 
               
               
                   
                   
                 proteins. 
               
               
                 824 
                 PR00048 
                 C2H2-TYPE ZINC 
                 PR00048A 10.52 6.143e-13 252-266 
               
               
                   
                   
                 FINGER SIGNATURE 
                 PR00048A 10.52 7.429e-13 476-490 
               
               
                   
                   
                   
                 PR00048A 10.52 3.118e-12 336-350 
               
               
                   
                   
                   
                 PR00048A 10.52 3.118e-12 364-378 
               
               
                   
                   
                   
                 PR00048A 10.52 4.706e-12 504-518 
               
               
                   
                   
                   
                 PR00048A 10.52 8.412e-12 224-238 
               
               
                   
                   
                   
                 PR00048A 10.52 3.842e-11 392-406 
               
               
                   
                   
                   
                 PR00046A 10.52 6.211e-11 308-322 
               
               
                   
                   
                   
                 PR00048A 10.52 6.211e-11 448-462 
               
               
                   
                   
                   
                 PR00048B 6.02 7.231e-11 492-502 
               
               
                   
                   
                   
                 PR00048B 6.02 3.250e-10 240-250 
               
               
                   
                   
                   
                 PR00048A 10.52 6.870e-10 420-434 
               
               
                   
                   
                   
                 PR00048B 6.02 2.421e-09 380-390 
               
               
                 825 
                 PR00122 
                 VACUOLAR ATP 
                 PR00122D 9.97 7.214e-11 103-127 
               
               
                   
                   
                 SYNTRASE 16 KD 
                 PR00122C 8.20 9.526e-10 76-103 
               
               
                   
                   
                 SUBUNIT SIGNATURE 
               
               
                 826 
                 BL00518 
                 Zinc finger, C3HC4 type 
                 BL00518 12.23 6.571e-10 30-39 
               
               
                   
                   
                 (RING finger), proteins. 
               
               
                 828 
                 BL01160 
                 Kinesin light chain 
                 BL01160B 19.54 1.610e-09 33-87 
               
               
                   
                   
                 repeat proteins. 
                 BL01160B 19.54 9.619e-09 65-119 
               
               
                 835 
                 PD02411 
                 PROTEIN 
                 PD02411 21.89 6.786e-15 3967-4001 
               
               
                   
                   
                 TRANSCRIPTION 
               
               
                   
                   
                 REGULATION NUCLEAR. 
               
               
                 836 
                 DM01970 
                 0 kw ZK632.12 
                 DM01970B 8.60 9.423e-10 111-124 
               
               
                   
                   
                 YDR313C ENDOSOMAL III. 
               
               
                 837 
                 PR00048 
                 C2H2-TYPE ZINC 
                 PR00048A 10.52 2.174e-10 177-191 
               
               
                   
                   
                 FINGER SIGNATURE 
               
               
                 842 
                 PF00922 
                 Vesiculovirus phosphoprotein. 
                 PF00922A 19.17 7.724e-09 276-310 
               
               
                 844 
                 PD02059 
                 CORE POLYPROTEIN 
                 PD02059A 28.10 5.950e-10 34-75 
               
               
                   
                   
                 PROTEIN GAG 
               
               
                   
                   
                 CONTAINS: P. 
               
               
                 846 
                 BL00326 
                 Tropomyosins proteins. 
                 BL00326D 8.76 8.065e-09 165-206 
               
               
                 847 
                 BL00326 
                 Tropomyosins proteins. 
                 BL00326D 8.76 8.065e-09 173-214 
               
               
                 849 
                 PR00563 
                 BETA-3 ADRENERGIC 
                 PR00563B 3.98 8.141e-09 8-28 
               
               
                   
                   
                 RECEPTOR SIGNATURE 
               
               
                 851 
                 PR00450 
                 RECOVERIN FAMILY 
                 PR00450C 12.22 1.570e-09 285-307 
               
               
                   
                   
                 SIGNATURE 
               
               
                 853 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 8.800e-14 290-303 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 4.000e-13 234-247 
               
               
                   
                   
                   
                 PD00066 13.92 4.429e-12 262-275 
               
               
                   
                   
                   
                 PD00066 13.92 9.217e-11 206-219 
               
               
                   
                   
                   
                 PD00066 13.92 3.769e-10 505-518 
               
               
                   
                   
                   
                 PD00066 13.92 4.115e-10 449-462 
               
               
                   
                   
                   
                 PD00066 13.92 4.462e-10 533-546 
               
               
                   
                   
                   
                 PD00066 13.92 6.538e-10 477-490 
               
               
                 854 
                 BL00615 
                 C-type lectin domain proteins. 
                 BL00615A 16.68 8.920e-11 137-155 
               
               
                 855 
                 BL00615 
                 C-type lectin domain proteins. 
                 BL00615A 16.68 8.920e-11 176-194 
               
               
                 856 
                 BL00018 
                 EF-hand calcium-binding 
                 BL00018 7.41 9.000e-14 65-78 
               
               
                   
                   
                 domain proteins. 
               
               
                 858 
                 PR00019 
                 LEUCINE-RICH REPEAT 
                 PR00019B 11.36 1.000e-09 219-233 
               
               
                   
                   
                 SIGNATURE 
               
               
                 860 
                 PD02474 
                 SYNTHASE SMALL 
                 PD02474B 21.08 8.568e-09 199-238 
               
               
                   
                   
                 SUBUNIT ACETOLACT. 
               
               
                 861 
                 PF00922 
                 Vesiculovirus phosphoprotein. 
                 PF00922A 19.17 1.000e-08 249-283 
               
               
                 864 
                 PR00289 
                 DISINTEGRIN 
                 PR00289B 11.79 1.947e-09 522-535 
               
               
                   
                   
                 SIGNATURE 
               
               
                 866 
                 PF00242 
                 DNA polymerase (viral) 
                 PF00242F 12.18 8.522e-09 197-219 
               
               
                   
                   
                 N-terminal domain proteins. 
               
               
                 867 
                 PR00780 
                 LEUSERPIN 2 
                 PR00780B 4.89 4.491e-09 262-285 
               
               
                   
                   
                 SIGNATURE 
               
               
                 868 
                 BL00226 
                 Intermediate filaments proteins. 
                 BL00226D 19.10 8.027e-13 208-255 
               
               
                 869 
                 PD01876 
                 ANTIGEN MELANOMA- 
                 PD01876C 21.73 3.326e-15 461-534 
               
               
                   
                   
                 ASSOCIATED MULTIGENE 
                 PD01876C 21.73 3.045e-10 735-788 
               
               
                   
                   
                 FAMILY TUM. 
               
               
                 870 
                 PR00747 
                 GLYCOSYL HYDROLASE 
                 PR00747C 12.06 8.767e-09 337-356 
               
               
                   
                   
                 FAMILY 47 SIGNATURE 
               
               
                 872 
                 DM01782 
                 HYDROGENASE (FE) 
                 DM01782C 13.88 4.400e-19 349-368 
               
               
                   
                   
                 LARGE CHAIN. 
                 DM01782F 9.01 4.375e-18 499-515 
               
               
                   
                   
                   
                 DM01782B 17.29 3.412e-10 294-327 
               
               
                 873 
                 BL00226 
                 Intermediate filaments proteins. 
                 BL00226D 19.10 7.375e-38 321-368 
               
               
                   
                   
                   
                 BL00226B 23.86 7.107e-32 155-203 
               
               
                   
                   
                   
                 BL00226C 13.23 3.100e-19 220-251 
               
               
                   
                   
                   
                 BL00226A 12.77 7.000e-15 55-70 
               
               
                   
                   
                   
                 BL00226D 19.10 7.800e-09 254-301 
               
               
                 874 
                 DM01415 
                 6 SALIVARY GLUE 
                 DM01415B 13.78 9.518e-10 4-52 
               
               
                   
                   
                 PROTEIN. 
               
               
                 876 
                 PR00860 
                 VERTEBRATE 
                 PR00860B 7.04 2.929e-20 74-88 
               
               
                   
                   
                 METALLOTHIONEIN 
                 PR00860A 5.46 5.655e-13 52-65 
               
               
                   
                   
                 SIGNATURE 
                 PR00860C 9.61 2.400e-12 88-98 
               
               
                 877 
                 PR00360 
                 C2 DOMAIN SIGNATURE 
                 PR00360B 13.61 7.136e-09 572-586 
               
               
                 881 
                 DM01206 
                 CORONAVIRUS 
                 DM01206B 10.69 8.767e-10 567-587 
               
               
                   
                   
                 NUCLEOCAPSID 
                 DM01206B 10.69 1.000e-09 563-583 
               
               
                   
                   
                 PROTEIN. 
               
               
                 882 
                 BL00092 
                 N-6 Adenine-specific DNA 
                 BL00092 5.35 2.000e-09 136-145 
               
               
                   
                   
                 methylases proteins. 
               
               
                 883 
                 PR00511 
                 TEKTIN SIGNATURE 
                 PR00511A 13.59 3.700e-14 113-130 
               
               
                 885 
                 PR00764 
                 COMPLEMENT C9 
                 PR00764F 16.69 2.286e-09 158-179 
               
               
                   
                   
                 SIGNATURE 
               
               
                 887 
                 BL01279 
                 Protein-L-isoaspartate 
                 BL01279A 24.27 3.691e-09 419-467 
               
               
                   
                   
                 (D-aspartate) 
               
               
                   
                   
                 O-methyltransferase signa. 
               
               
                 889 
                 PD01719 
                 PRECURSOR 
                 PD01719A 12.89 2.603e-11 259-287 
               
               
                   
                   
                 GLYCOPROTEIN SIGNAL 
                 PD01719A 12.89 8.105e-10 199-227 
               
               
                   
                   
                 RE. 
               
               
                 890 
                 BL01162 
                 Quinone oxidoreductase/ 
                 BL01162C 22.80 1.269e-18 151-195 
               
               
                   
                   
                 zeta-crystallin proteins. 
                 BL01162A 15.38 1.265e-11 64-87 
               
               
                 893 
                 PD01066 
                 PROTEIN ZINC FINGER 
                 PD01066 19.43 5.415e-26 46-85 
               
               
                   
                   
                 ZINC-FINGER METAL- 
               
               
                   
                   
                 BINDING NU. 
               
               
                 894 
                 PD02910 
                 TRANSCRIPTION 
                 PD02910A 15.43 9.839e-09 62-97 
               
               
                   
                   
                 PROTEIN FACTOR 
               
               
                   
                   
                 REGULATION A. 
               
               
                 895 
                 PD02199 
                 SUBUNIT HYDROGEN ION 
                 PD02199A 20.58 1.000e-40 10-61 
               
               
                   
                   
                 TRANSPORT T. 
                 PD02199D 13.18 1.000e-40 364-405 
               
               
                   
                   
                   
                 PD02199F 15.02 1.000e-40 440-482 
               
               
                   
                   
                   
                 PD02199J 11.42 1.000e-40 723-762 
               
               
                   
                   
                   
                 PD02199K 15.22 1.000e-40 792-831 
               
               
                   
                   
                   
                 PD02199G 9.43 4.447e-24 531-555 
               
               
                   
                   
                   
                 PD02199B 27.90 1.474e-22 263-306 
               
               
                   
                   
                   
                 PD02199H 13.62 2.636e-21 576-599 
               
               
                   
                   
                   
                 PD02199E 7.56 8.642e-19 405-424 
               
               
                   
                   
                   
                 PD02199C 17.60 8.085e-14 313-329 
               
               
                   
                   
                   
                 PD02199I 8.90 4.780e-09 616-624 
               
               
                 896 
                 BL00218 
                 Amino acid permeases proteins. 
                 BL00218E 23.30 5.920e-10 343-383 
               
               
                 897 
                 BL00048 
                 Protamine P1 proteins. 
                 BL00048 6.39 9.526e-10 160-187 
               
               
                 900 
                 BL00811 
                 Oleosins proteins. 
                 BL00811B 10.57 9.791e-09 307-336 
               
               
                 904 
                 BL00415 
                 Synapsins proteins. 
                 BL00415N 4.29 4.153e-09 301-345 
               
               
                 905 
                 BL00107 
                 Protein kinases ATP-binding 
                 BL00107A 18.39 3.250e-17 133-164 
               
               
                   
                   
                 region proteins. 
               
               
                 906 
                 PR00449 
                 TRANSFORMING PROTEIN 
                 PR00449A 13.20 4.971e-14 4-26 
               
               
                   
                   
                 P21 RAS SIGNATURE 
               
               
                 908 
                 BL00317 
                 WAP-type ‘four-disulfide core’ 
                 BL00317B 14.58 3.550e-13 48-70 
               
               
                   
                   
                 domain proteins. 
               
               
                 909 
                 BL01019 
                 ADP-ribosylation factors 
                 BL01019B 19.49 7.517e-21 95-150 
               
               
                   
                   
                 family proteins. 
               
               
                 910 
                 PD00066 
                 PROTEIN ZINC-FINGER 
                 PD00066 13.92 2.385e-15 128-141 
               
               
                   
                   
                 METAL-BINDI. 
                 PD00066 13.92 5.714e-12 100-113 
               
               
                 911 
                 PR00048 
                 C2H2-TYPE ZINC 
                 PR00045A 10.52 1.000e-11 174-188 
               
               
                   
                   
                 FINGER SIGNATURE 
                 PR00048B 6.02 1.692e-11 162-172 
               
               
                 912 
                 PF00651 
                 BTB (also known as BR-C/Ttk) 
                 PR00651 15.00 2.895e-11 45-58 
               
               
                   
                   
                 domain proteins. 
               
               
                 913 
                 DM00547 
                 1 kw CHROMO 
                 DM00547F 23.43 7.643e-34 606-653 
               
               
                   
                   
                 BROMODOMAIN SHADOW 
                 DM00547B 11.28 7.907e-16 155-169 
               
               
                   
                   
                 GLOBAL. 
                 DM00547C 17.30 8.650e-14 209-231 
               
               
                   
                   
                   
                 DM00547D 11.60 6.500e-13 277-291 
               
               
                   
                   
                   
                 DM00547E 13.94 1.000e-11 307-330 
               
               
                 914 
                 BL01115 
                 GTP-binding nuclear protein 
                 BL01115A 10.22 5.330e-11 18-62 
               
               
                   
                   
                 ran proteins. 
               
               
                 919 
                 BL01283 
                 T-box domain proteins. 
                 BL01283D 11.70 7.868e-31 59-92 
               
               
                   
                   
                   
                 BL01283C 13.05 2.537e-14 25-39 
               
               
                 922 
                 DM01503 
                 1 HERPESVIRUS 
                 DM01803A 10.51 8.699e-09 100-121 
               
               
                   
                   
                 GLYCOPROTEIN H. 
               
               
                 924 
                 BL00470 
                 Isocitrate and isopropylmalate 
                 BL00470A 16.25 5.179e-14 10-31 
               
               
                   
                   
                 dehydrogenases proteins. 
                 BL00470C 15.43 4.103e-10 223-238 
               
               
                   
                   
                   
                 BL00470E 16.52 1.900e-09 287-297 
               
               
                 925 
                 PF00023 
                 Ank repeat proteins. 
                 PF00023A 16.03 3.893e-09 44-60 
               
               
                   
                   
                   
                 PF00023B 14.20 9.182e-09 40-50 
               
               
                 926 
                 PF00023 
                 Ank repeat proteins. 
                 PF00023A 16.03 3.893e-09 72-88 
               
               
                   
                   
                   
                 PF00023B 14.20 9.182e-09 68-78 
               
               
                 929 
                 PD01066 
                 PROTEIN ZINC FINGER 
                 PD01066 19.43 2.019e-26 51-90 
               
               
                   
                   
                 ZINC-FINGER METAL- 
               
               
                   
                   
                 BINDING NU. 
               
               
                 930 
                 PR00830 
                 ENDOPEPTIDASE LA 
                 PR00830A 8.41 4.927e-13 222-242 
               
               
                   
                   
                 (LON) SERINE 
               
               
                   
                   
                 PROTEASE (S16) 
               
               
                   
                   
                 SIGNATURE 
               
               
                 931 
                 BL00456 
                 Sodium:solute symporter 
                 BL00456A 22.59 1.957e-32 35-90 
               
               
                   
                   
                 family proteins. 
                 BL00456B 18.94 9.780e-17 111-141 
               
               
                 932 
                 BL00456 
                 Sodium:solute symporter 
                 BL00456A 22.59 1.957e-32 35-90 
               
               
                   
                   
                 family proteins. 
                 BL00456C 24.55 1.225e-31 173-228 
               
               
                   
                   
                   
                 BL00456B 18.94 9.780e-17 111-141 
               
               
                 936 
                 BL00290 
                 Immunoglobulins and major 
                 BL00290A 20.89 1.818e-11 159-182 
               
               
                   
                   
                 histocompatibility 
               
               
                   
                   
                 complex proteins. 
               
               
                 937 
                 PR00830 
                 ENDOPEPTIDASE LA 
                 PR0083CA 8.41 5.897e-10 352-372 
               
               
                   
                   
                 (LON) SERINE 
               
               
                   
                   
                 PROTEASE (S16) 
               
               
                   
                   
                 SIGNATURE 
               
               
                 938 
                 PF00651 
                 BTB (also known as BR-C/TtK) 
                 PR00651 15.00 7.000e-10 50-63 
               
               
                   
                   
                 domain proteins. 
               
               
                 939 
                 PD00306 
                 PROTEIN GLYCOPROTEIN 
                 PD00306A 10.26 6.625e-13 544-558 
               
               
                   
                   
                 PRECURSOR RE. 
               
               
                 940 
                 PD00306 
                 PROTEIN GLYCOPROTEIN 
                 PD00306A 10.26 6.625e-13 544-558 
               
               
                   
                   
                 PRECURSOR RE. 
               
               
                 941 
                 PD00306 
                 PROTEIN GLYCOPROTEIN 
                 PD00306A 10.26 6.625e-13 544-558 
               
               
                   
                   
                 PRECURSOR RE. 
               
               
                 942 
                 PF00938 
                 Lipoprotein. 
                 PF00938E 19.50 6.096e-09 272-307 
               
               
                 943 
                 PF00925 
                 GTP cyclohydrolase II. 
                 PF00925F 13.23 9.850e-09 356-367 
               
               
                 945 
                 BL00226 
                 Intermediate filaments proteins. 
                 BL00226A 12.77 5.355e-13 139-154 
               
               
                 947 
                 PF00035 
                 Double-stranded RNA 
                 PF00035B 12.06 7.750e-09 273-287 
               
               
                   
                   
                 binding motif. 
               
               
                 948 
                 PF00622 
                 Domain in SPla and the 
                 PF00622B 21.00 9.250e-11 170-192 
               
               
                   
                   
                 RYanodine Receptor. 
               
               
                   
               
               
                 *Results include in order: accession number subtype; raw score; p-value; position of signature in amino acid sequence.  
               
             
          
         
       
     
     
       
         
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                 SEQ 
                   
                   
                   
                   
               
               
                 ID NO: 
                 pFAM NAME 
                 DESCRIPTION 
                 p-value 
                 pFAM SCORE 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 2 
                 UCH-2 
                 Ubiquitin carboxyl-terminal hydrolase family 2 
                 5.9e-26 
                 99.7 
               
               
                 5 
                 SH2 
                 Src homology domain 2 
                 8.5e-22 
                 66.5 
               
               
                 6 
                 SH2 
                 Src homology domain 2 
                 8.5e-22 
                 66.5 
               
               
                 7 
                 RCC1 
                 Regulator of chromosome condensation (RCC1) 
                 4.4e-18 
                 68.4 
               
               
                 14 
                 UQ_con 
                 Ubiquitin-conjugating enzyme 
                 3.2e-49 
                 176.9 
               
               
                 15 
                 UQ_con 
                 Ubiquitin-conjugating enzyme 
                 1.2e-68 
                 241.5 
               
               
                 20 
                 gntR 
                 Bacterial regulatory proteins, gntR family 
                 0.062 
                 11.4 
               
               
                 21 
                 gntR 
                 Bacterial regulatory proteins, gntR family 
                 0.062 
                 11.4 
               
               
                 23 
                 kinesin 
                 Kinesin motor domain 
                 2.9e-128 
                 439.5 
               
               
                 27 
                 Kelch 
                 Kelch motif 
                 7.9e-71 
                 248.7 
               
               
                 29 
                 kinesin 
                 Kinesin motor domain 
                 1.9e-171 
                 583.0 
               
               
                 30 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 8.5e-09 
                 35.7 
               
               
                 32 
                 Aa_trans 
                 Transmembrane amino acid transporter protein 
                 3.1e-53 
                 190.3 
               
               
                 34 
                 EGF 
                 EGF-like domain 
                 3.9e-24 
                 93.6 
               
               
                 38 
                 ig 
                 Immunoglobulin domain 
                 6.2e-06 
                 24.2 
               
               
                 39 
                 LRR 
                 Leucine Rich Repeat 
                 1.1e-10 
                 48.9 
               
               
                 43 
                 CK_II_beta 
                 Casein kinase II regulatory subunit 
                 4.5e-69 
                 242.9 
               
               
                 45 
                 COX6B 
                 Cytochrome oxidase c subunit VIb 
                 0.064 
                 −6.7 
               
               
                 46 
                 RNA_pol_B 
                 RNA polymerase beta subunit 
                 0 
                 1206.8 
               
               
                 47 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                   2e-07 
                 28.3 
               
               
                 48 
                 HLH 
                 Helix-loop-helix DNA-binding domain 
                 1.5e-07 
                 38.5 
               
               
                 49 
                 ras 
                 Ras family 
                 3.3e-12 
                 2.0 
               
               
                 50 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 1.9e-43 
                 157.8 
               
               
                 52 
                 ig 
                 Immunoglobulin domain 
                 7.2e-08 
                 30.4 
               
               
                 54 
                 PX 
                 PX domain 
                 3.7e-06 
                 33.9 
               
               
                 65 
                 Defensin_propep 
                 Defensin propeptide 
                   3e-25 
                 97.3 
               
               
                 67 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                   2e-55 
                 197.5 
               
               
                 71 
                 pentaxin 
                 Pentaxin family 
                 3.4e-18 
                 66.3 
               
               
                 73 
                 SSF 
                 Sodium:solute symporter family 
                 1.7e-05 
                 −65.8 
               
               
                 75 
                 AMP-binding 
                 AMP-binding enzyme 
                 1.1e-12 
                 −49.0 
               
               
                 78 
                 transmembrane4 
                 Transmembrane 4 family 
                 6.4e-05 
                 18.7 
               
               
                 80 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 4.9e-30 
                 113.2 
               
               
                 81 
                 fn3 
                 Fibronectin type III domain 
                 1.8e-13 
                 58.2 
               
               
                 83 
                 polyprenyl_synt 
                 Polyprenyl synthetases 
                 0.015 
                 −83.6 
               
               
                 84 
                 Defensin_propep 
                 Defensin propeptide 
                   3e-25 
                 97.3 
               
               
                 85 
                 MAGE 
                 MAGE family 
                 3.5e-34 
                 127.0 
               
               
                 86 
                 LRR 
                 Leucine Rich Repeat 
                 7.7e-15 
                 62.7 
               
               
                 87 
                 Cytidylyltransf 
                 Cytidylyltransferase 
                 1.4e-05 
                 29.3 
               
               
                 90 
                 lipase 
                 Lipase 
                 2.5e-15 
                 55.2 
               
               
                 96 
                 homeobox 
                 Homeobox domain 
                 1.1e-30 
                 115.3 
               
               
                 101 
                 fn3 
                 Fibronectin type III domain 
                 4.7e-78 
                 272.7 
               
               
                 102 
                 ig 
                 Immunoglobulin domain 
                 0.00045 
                 18.2 
               
               
                 103 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 6.7e-08 
                 32.8 
               
               
                 104 
                 Trans_recep 
                 Transient receptor 
                 1.9e-34 
                 115.7 
               
               
                 105 
                 Tropomyosin 
                 Tropomyosins 
                 0.0086 
                 11.3 
               
               
                 109 
                 p450 
                 Cytochrome P450 
                 1.8e-61 
                 217.6 
               
               
                 116 
                 Tropomyosin 
                 Tropomyosins 
                 0.0086 
                 11.3 
               
               
                 117 
                 Tropomyosin 
                 Tropomyosins 
                 0.0086 
                 11.3 
               
               
                 118 
                 aa_permeases 
                 Amino acid permease 
                 3.2e-06 
                 −173.3 
               
               
                 120 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 1.3e-124 
                 427.4 
               
               
                 122 
                 C2 
                 C2 domain 
                 1.1e-38 
                 142.0 
               
               
                 123 
                 ig 
                 Immunoglobulin domain 
                 0.00079 
                 17.4 
               
               
                 127 
                 WD40 
                 WD domain, G-beta repeat 
                 9.6e-15 
                 62.4 
               
               
                 130 
                 FYVE 
                 FYVE zinc finger 
                 7.4e-23 
                 86.0 
               
               
                 131 
                 PH 
                 PH domain 
                 3.9e-25 
                 94.8 
               
               
                 133 
                 KRAB 
                 KRAB box 
                 1.6e-24 
                 94.9 
               
               
                 134 
                 Ribosomal_L11 
                 Ribosomal protein L11 
                 3.9e-64 
                 226.5 
               
               
                 136 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 2.1e-185 
                 629.4 
               
               
                 137 
                 Band_7 
                 SPFH domain/Band 7 family 
                 6.5e-35 
                 129.4 
               
               
                 139 
                 TPR 
                 TPR Domain 
                 5.3e-16 
                 66.6 
               
               
                 142 
                 WH1 
                 WH1 domain 
                 6.4e-05 
                 29.8 
               
               
                 143 
                 zf-DHHC 
                 DHHC zinc finger domain 
                 0.033 
                 −11.5 
               
               
                 147 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 9.2e-82 
                 285.0 
               
               
                 149 
                 7tm_2 
                 7 transmembrane receptor (Secretin family) 
                 1.2e-22 
                 88.7 
               
               
                 151 
                 lectin_c 
                 Lectin C-type domain 
                 0.0097 
                 3.8 
               
               
                 152 
                 PDZ 
                 PDZ domain (Also known as DHR or GLGF). 
                 0.0031 
                 24.2 
               
               
                 153 
                 cadherin 
                 Cadherin domain 
                 3.7e-95 
                 329.6 
               
               
                 155 
                 COesterase 
                 Carboxylesterases 
                   7e-48 
                 166.8 
               
               
                 156 
                 DSPc 
                 Dual specificity phosphatase, catalytic domain 
                 2.8e-29 
                 110.7 
               
               
                 157 
                 efhand 
                 EF hand 
                 2.2e-14 
                 61.2 
               
               
                 159 
                 A2M 
                 Alpha-2-macroglobulin family 
                 2.2e-07 
                 25.5 
               
               
                 160 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 8.8e-68 
                 238.6 
               
               
                 161 
                 Nucleoside_tra2 
                 Na+ dependent nucleoside transporter 
                 8e-188 
                 637.4 
               
               
                 166 
                 ras 
                 Ras family 
                 5.5e-31 
                 116.4 
               
               
                 167 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 3.2e-06 
                 24.4 
               
               
                 168 
                 LRR 
                 Leucine Rich Repeat 
                 1.3e-06 
                 35.4 
               
               
                 169 
                 RasGAP 
                 GTPase-activator protein for Ras-like GTPase 
                 6.4e-28 
                 106.2 
               
               
                 172 
                 LMWPc 
                 Low molecular weight phosphotyrosine protein phosphatase 
                 9.7e-56 
                 198.6 
               
               
                 175 
                 lectin_c 
                 Lectin C-type domain 
                 5.4e-06 
                 33.3 
               
               
                 178 
                 PK 
                 Pyruvate kinase 
                 5.4e-12 
                 46.3 
               
               
                 179 
                 vwa 
                 von Willebrand factor type A domain 
                 4.1e-63 
                 223.1 
               
               
                 180 
                 neur_chan 
                 Neurotransmitter-gated ion-channel 
                 1.5e-120 
                 413.9 
               
               
                 181 
                 C4 
                 C-terminal tandem repeated domain in type 4 procollagen 
                 1.4e-148 
                 507.0 
               
               
                 187 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 1.2e-25 
                 98.6 
               
               
                 188 
                 Ribosomal_S2 
                 Ribosomal protein S2 
                 3.3e-79 
                 276.5 
               
               
                 191 
                 ATP-synt_ab 
                 ATP synthase alpha/beta family 
                 5.7e-09 
                 −1.3 
               
               
                 192 
                 ATP-synt_ab 
                 ATP synthase alpha/beta family 
                 3.1e-11 
                 49.7 
               
               
                 193 
                 ank 
                 Ank repeat 
                 3.5e-33 
                 123.7 
               
               
                 195 
                 GTP_EFTU 
                 Elongation factor Tu family 
                 8.1e-33 
                 113.3 
               
               
                 197 
                 RF-1 
                 Peptidyl-tRNA hydrolase domain 
                 0.00034 
                 10.7 
               
               
                 200 
                 WD40 
                 WD domain, G-beta repeat 
                   1e-05 
                 32.4 
               
               
                 201 
                 Band_41 
                 FERM domain (Band 4.1 family) 
                 5.3e-86 
                 269.7 
               
               
                 205 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 1.6e-90 
                 314.1 
               
               
                 207 
                 SCP 
                 SCP-like extracellular protein 
                   1e-15 
                 60.4 
               
               
                 208 
                 ras 
                 Ras family 
                 1.5e-15 
                 40.0 
               
               
                 211 
                 6PF2K 
                 6-phosphofructo-2-kinase 
                 5.2e-152 
                 518.4 
               
               
                 212 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                   3e-104 
                 359.8 
               
               
                 215 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 3.2e-92 
                 319.8 
               
               
                 216 
                 Oxysterol_BP 
                 Oxysterol-binding protein 
                 4.3e-48 
                 173.2 
               
               
                 219 
                 pentaxin 
                 Pentaxin family 
                 2.6e-40 
                 142.7 
               
               
                 220 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 6.2e-08 
                 30.0 
               
               
                 221 
                 Peptidase_M1 
                 Peptidase family M1 
                 1.5e-182 
                 529.4 
               
               
                 222 
                 ig 
                 Immunoglobulin domain 
                 3.1e-07 
                 28.4 
               
               
                 224 
                 BTB 
                 BTB/POZ domain 
                 1.8e-27 
                 104.7 
               
               
                 225 
                 F-box 
                 F-box domain. 
                 3.5e-05 
                 30.6 
               
               
                 229 
                 Na_Ca_Ex 
                 Sodium/calcium exchanger protein 
                 1.1e-23 
                 92.1 
               
               
                 231 
                 lactamase_B 
                 Metallo-beta-lactamase superfamily 
                 0.01 
                 −5.3 
               
               
                 232 
                 fibrinogen_C 
                 Fibrinogen beta and gamma chains, C-terminal globular domain 
                 7.5e-40 
                 140.2 
               
               
                 233 
                 MIF 
                 Macrophage migration inhibitory factor (MIF) 
                 5.4e-66 
                 232.7 
               
               
                 234 
                 SSF 
                 Sodium:solute symporter family 
                 1.7e-234 
                 792.4 
               
               
                 235 
                 Cation_efflux 
                 Cation efflux family 
                 2.2e-63 
                 224.0 
               
               
                 237 
                 AAA 
                 ATPases associated with various cellular activities (AAA) 
                 2.6e-85 
                 296.8 
               
               
                 238 
                 HCO3_cotransp 
                 HCO3- transporter family 
                 0 
                 1395.3 
               
               
                 239 
                 homeobox 
                 Homeobox domain 
                 1.1e-14 
                 62.2 
               
               
                 243 
                 GST 
                 Glutathione S-transferases. 
                 0.0024 
                 14.4 
               
               
                 244 
                 Viral_helicasel 
                 Viral (Superfamily 1) RNA helicase 
                 0.0019 
                 14.7 
               
               
                 245 
                 Na_Galacto_symp 
                 Sodium:galactoside symporter family 
                 0.0068 
                 −94.4 
               
               
                 246 
                 PPR 
                 PPR repeat 
                 0.0024 
                 24.5 
               
               
                 249 
                 ENV_polyprotein 
                 ENV polyprotein (coat polyprotein) 
                 3.9e-45 
                 155.2 
               
               
                 252 
                 UQ_con 
                 Ubiquitin-conjugating enzyme 
                 7.6e-15 
                 62.8 
               
               
                 254 
                 7tm_1 
                 7 transmembrane receptor (rhodopsin family) 
                   2e-32 
                 105.2 
               
               
                 255 
                 7tm_1 
                 7 transmembrane receptor (rhodopsin family) 
                 9.6e-43 
                 137.9 
               
               
                 256 
                 UBA 
                 UBA domain 
                 1.2e-08 
                 42.1 
               
               
                 259 
                 transmembrane4 
                 Transmembrane 4 family 
                 4.2e-44 
                 144.0 
               
               
                 267 
                 thyroglobulin_1 
                 Thyroglobulin type-1 repeat 
                 3.2e-35 
                 130.4 
               
               
                 268 
                 annexin 
                 Annexin 
                 6.7e-80 
                 278.9 
               
               
                 269 
                 annexin 
                 Annexin 
                 8.5e-122 
                 418.0 
               
               
                 270 
                 annexin 
                 Annexin 
                 6.7e-80 
                 278.9 
               
               
                 271 
                 Armadillo_seg 
                 Armadillo/beta-catenin-like repeats 
                 6.4e-06 
                 33.1 
               
               
                 273 
                 p450 
                 Cytochrome P450 
                 2.3e-132 
                 453.1 
               
               
                 274 
                 p450 
                 Cytochrome P450 
                 5.9e-52 
                 186.0 
               
               
                 275 
                 A2M_N 
                 Alpha-2-macroglobulin family N-terminal region 
                 2.1e-72 
                 247.4 
               
               
                 277 
                 Thymosin 
                 Thymosin beta-4 family 
                 2.3e-16 
                 67.8 
               
               
                 279 
                 WD40 
                 WD domain, G-beta repeat 
                 5.8e-19 
                 76.4 
               
               
                 288 
                 F-box 
                 F-box domain. 
                 0.012 
                 22.3 
               
               
                 289 
                 LRR 
                 Leucine Rich Repeat 
                 1.3e-17 
                 72.0 
               
               
                 290 
                 TPR 
                 TPR Domain 
                 7.5e-54 
                 192.3 
               
               
                 293 
                 cadherin 
                 Cadherin domain 
                 8.2e-07 
                 36.1 
               
               
                 297 
                 UCH-1 
                 Ubiquitin carboxyl-terminal hydrolases family 2 
                 4.9e-08 
                 40.1 
               
               
                 298 
                 ank 
                 Ank repeat 
                 9.1e-74 
                 258.5 
               
               
                 302 
                 Clq 
                 Clq domain 
                 0.023 
                 14.1 
               
               
                 304 
                 laminin_Nterm 
                 Laminin N-terminal (Domain VI) 
                 3.2e-52 
                 186.9 
               
               
                 305 
                 enolase 
                 Enol-ase 
                 2.4e-69 
                 243.8 
               
               
                 307 
                 Nol1_Nop2_Sun 
                 NOL1/NOP2/sun family 
                 0.0015 
                 15.2 
               
               
                 308 
                 HIT 
                 HIT family 
                 3.2e-50 
                 180.3 
               
               
                 309 
                 ank 
                 Ank repeat 
                 1e-20 
                 82.3 
               
               
                 310 
                 lectin_c 
                 Lectin C-type domain 
                 8.8e-19 
                 75.8 
               
               
                 311 
                 gpdh 
                 glyceraldehyde 3-phosphate dehydrogenases 
                 8.4e-237 
                 793.9 
               
               
                 314 
                 mito_carr 
                 Mitochondrial carrier proteins 
                   2e-59 
                 206.6 
               
               
                 315 
                 serpin 
                 Serpins (serine protease inhibitors) 
                 1.5e-109 
                 372.9 
               
               
                 316 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 5.1e-141 
                 481.9 
               
               
                 317 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 1.2e-132 
                 454.1 
               
               
                 318 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 3.2e-122 
                 419.4 
               
               
                 319 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 1.3e-119 
                 410.8 
               
               
                 320 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 1.8e-122 
                 420.3 
               
               
                 321 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 1.7e-131 
                 450.2 
               
               
                 323 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                   4e-144 
                 492.2 
               
               
                 324 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 3.8e-105 
                 362.7 
               
               
                 325 
                 MHC_I 
                 Class I Histocompatibility antigen, domains alpha 1 and 2 
                 1.3e-139 
                 477.2 
               
               
                 326 
                 Kelch 
                 Kelch motif 
                 1.4e-101 
                 350.9 
               
               
                 328 
                 Glycos_transf_2 
                 Glycosyl transferases 
                 1.9e-09 
                 44.8 
               
               
                 332 
                 ig 
                 Immunoglobulin domain 
                 3.3e-07 
                 28.3 
               
               
                 333 
                 UCH-1 
                 Ubiquitin carboxyl-terminal hydrolases family 2 
                 1.1e-12 
                 55.6 
               
               
                 336 
                 ATP-gua_Ptrans 
                 ATP:guanido phosphotransferase 
                 4.1e-15 
                 56.6 
               
               
                 337 
                 UBX 
                 UBX domain 
                 6.5e-18 
                 72.9 
               
               
                 338 
                 UBX 
                 UBX domain 
                 6.5e-18 
                 72.9 
               
               
                 339 
                 DnaJ 
                 DnaJ domain 
                   1e-36 
                 135.4 
               
               
                 340 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 5.3e-07 
                 26.9 
               
               
                 341 
                 PKD 
                 PKD domain 
                 0 
                 1485.5 
               
               
                 342 
                 CNH 
                 CNH domain 
                 2.7e-24 
                 94.2 
               
               
                 344 
                 RhoGAP 
                 RhOGAP domain 
                 1.8e-59 
                 211.0 
               
               
                 345 
                 Peptidase_M10 
                 Matrixin 
                 8.2e-110 
                 378.2 
               
               
                 346 
                 Peptidase_M10 
                 Matrixin 
                 8.2e-110 
                 378.2 
               
               
                 349 
                 UQ_con 
                 Ubiquitin-conjugating enzyme 
                 2.6e-06 
                 0.9 
               
               
                 350 
                 ig 
                 Immunoglobulin domain 
                 1.6e-236 
                 767.1 
               
               
                 351 
                 CNG_membrane 
                 Transmembrane region cyclic Nucleotide Gated Channel 
                 3.7e-108 
                 372.7 
               
               
                 353 
                 RGS 
                 Regulator of G protein signaling domain 
                 4.6e-49 
                 176.4 
               
               
                 354 
                 THF_DHG_CYH 
                 Tetrahydrofolate dehydrogenase/cyclohydrolase 
                   5e-106 
                 365.7 
               
               
                 355 
                 gln-synt 
                 Glutamine synthetase 
                 1.9e-194 
                 612.3 
               
               
                 356 
                 gln-synt 
                 Glutamine synthetase 
                   2e-39 
                 125.5 
               
               
                 357 
                 SCAN 
                 SCAN domain 
                 9.7e-61 
                 215.2 
               
               
                 358 
                 UPF0117 
                 Domain of unknown function DUF36 
                 1.3e-38 
                 131.0 
               
               
                 359 
                 Trans_recep 
                 Transient receptor 
                 0 
                 1115.3 
               
               
                 362 
                 Ammonium_transp 
                 Ammonium Transporter Family 
                 1.9e-56 
                 200.9 
               
               
                 363 
                 Kelch 
                 Kelch motif 
                 3.2e-50 
                 180.3 
               
               
                 365 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 7.4e-26 
                 88.2 
               
               
                 366 
                 SRCR 
                 Scavenger receptor cysteine-rich domain 
                 1.7e-25 
                 98.1 
               
               
                 367 
                 adn_short 
                 short chain dehydrogenase 
                 1.1e-37 
                 138.6 
               
               
                 369 
                 ANP 
                 Atrial natriuretic peptide 
                 1.5e-51 
                 183.0 
               
               
                 370 
                 EGF 
                 EGF-like domain 
                 3.6e-26 
                 100.4 
               
               
                 372 
                 STphosphatase 
                 Ser/Thr protein phosphatase 
                   1e-31 
                 112.7 
               
               
                 373 
                 FKBP 
                 FKBP-type peptidyl-prolyl cis-trans isomerases 
                 1.7e-57 
                 185.6 
               
               
                 374 
                 PX 
                 PX domain 
                 7.6e-16 
                 66.1 
               
               
                 375 
                 ras 
                 Ras family 
                 5.2e-16 
                 45.4 
               
               
                 376 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 1.9e-56 
                 200.9 
               
               
                 377 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 1.9e-56 
                 200.9 
               
               
                 379 
                 Peptidase_C1 
                 Papain family cysteine protease 
                 4.6e-119 
                 409.0 
               
               
                 380 
                 Peptidase_C1 
                 Papain family cysteine protease 
                 7.4e-109 
                 375.1 
               
               
                 382 
                 ig 
                 Immunoglobulin domain 
                 8.7e-10 
                 36.6 
               
               
                 384 
                 Sec7 
                 Sec7 domain 
                 4.5e-71 
                 249.5 
               
               
                 385 
                 cadherin 
                 Cadherin domain 
                 2.7e-95 
                 330.0 
               
               
                 387 
                 lipocalin 
                 Lipocalin/cytosolic fatty-acid binding protein family 
                   1e-35 
                 127.1 
               
               
                 388 
                 SH3 
                 SH3 domain 
                 1.5e-10 
                 48.4 
               
               
                 390 
                 UCH-2 
                 Ubiquitin carboxyl-terminal hydrolase family 2 
                 1.8e-20 
                 81.4 
               
               
                 392 
                 RCC1 
                 Regulator of chromosome condensation (RCC1) 
                 1.5e-14 
                 56.1 
               
               
                 397 
                 crystall 
                 Beta/Gamma crystallin 
                 3.3e-38 
                 140.4 
               
               
                 403 
                 PHD 
                 PHD-finger 
                 6.7e-15 
                 62.9 
               
               
                 404 
                 ferritin 
                 Ferritins 
                 4.1e-114 
                 386.1 
               
               
                 405 
                 CUB 
                 CUB domain 
                 2.4e-13 
                 57.8 
               
               
                 406 
                 ATP-gua_Ptrans 
                 ATP:guanido phosphotransferase 
                   5e-05 
                 20.7 
               
               
                 407 
                 SPRY 
                 SPRY domain 
                   2e-09 
                 44.8 
               
               
                 410 
                 ELM2 
                 ELM2 domain 
                 9.4e-15 
                 62.4 
               
               
                 411 
                 Reprolysin 
                 Reprolysin (M12B) family zinc metalloprotease 
                 7.2e-15 
                 56.4 
               
               
                 415 
                 ank 
                 Ank repeat 
                 3.5e-18 
                 73.8 
               
               
                 418 
                 C2 
                 C2 domain 
                   1e-75 
                 264.9 
               
               
                 419 
                 C2 
                 C2 domain 
                   1e-75 
                 264.9 
               
               
                 420 
                 p450 
                 Cytochrome P450 
                 9.8e-120 
                 411.2 
               
               
                 422 
                 aa_permeases 
                 Amino acid permease 
                 1.3e-08 
                 −108.1 
               
               
                 424 
                 kinesin 
                 Kinesin motor domain 
                 1.9e-115 
                 397.0 
               
               
                 425 
                 LRR 
                 Leucine Rich Repeat 
                 8.3e-26 
                 99.2 
               
               
                 426 
                 kinesin 
                 Kinesin motor domain 
                   8e-63 
                 222.1 
               
               
                 427 
                 zf-DHHC 
                 DHHC zinc finger domain 
                 9.1e-34 
                 125.6 
               
               
                 428 
                 EGF 
                 EGF-like domain 
                 3.2e-45 
                 163.6 
               
               
                 432 
                 TWIK_channel 
                 TASK K+ channel 
                 1.8e-09 
                 7.9 
               
               
                 433 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 2.3e-78 
                 273.8 
               
               
                 434 
                 PH 
                 PH domain 
                 0.00018 
                 21.0 
               
               
                 436 
                 ig 
                 Immunoglobulin domain 
                 9.2e-09 
                 33.3 
               
               
                 440 
                 LRR 
                 Leucine Rich Repeat 
                 2.8e-16 
                 67.5 
               
               
                 441 
                 MACPF 
                 MAC/Perforin domain 
                 0.016 
                 −71.3 
               
               
                 444 
                 efhand 
                 EF hand 
                 0.00027 
                 27.7 
               
               
                 448 
                 EPH_lbd 
                 Ephrin receptor ligand binding domain 
                 7.9e-135 
                 461.3 
               
               
                 456 
                 C1q 
                 C1q domain 
                 0.023 
                 14.1 
               
               
                 458 
                 ASC 
                 Amiloride-sensitive sodium channel 
                 9.2e-127 
                 434.5 
               
               
                 459 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 0.083 
                 10.4 
               
               
                 460 
                 PBP 
                 Phosphatidylethanolamine-binding protein 
                 1.2e-71 
                 251.4 
               
               
                 464 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 2.8e-12 
                 54.2 
               
               
                 466 
                 DEP 
                 Domain found in Dishevelled, Eg1-10, and Pleckstrin 
                 6.7e-18 
                 72.9 
               
               
                 470 
                 SCAN 
                 SCAN domain 
                 4.3e-52 
                 186.5 
               
               
                 471 
                 EGF 
                 EGF-like domain 
                 5.1e-28 
                 106.5 
               
               
                 473 
                 Ferric_reduct 
                 Ferric reductase like transmembrane component 
                 6.8e-74 
                 258.9 
               
               
                 474 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 5.7e-12 
                 53.2 
               
               
                 478 
                 CAP_GLY 
                 CAP-Gly domain 
                 3.4e-46 
                 166.9 
               
               
                 477 
                 PAP2 
                 PAP2 superfamily 
                 4.9e-10 
                 46.8 
               
               
                 476 
                 SCAN 
                 SCAN domain 
                 9.3e-70 
                 245.2 
               
               
                 480 
                 LRR 
                 Leucine Rich Repeat 
                   1e-13 
                 59.0 
               
               
                 483 
                 PH 
                 PH domain 
                   1e-15 
                 61.2 
               
               
                 484 
                 PH 
                 PH domain 
                 2.3e-21 
                 81.3 
               
               
                 489 
                 RhoGAP 
                 RhoGAP domain 
                 5.7e-57 
                 202.7 
               
               
                 493 
                 annexin 
                 Annexin 
                 4.7e-70 
                 246.2 
               
               
                 495 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 4.2e-06 
                 24.0 
               
               
                 497 
                 TK 
                 Thymidine kinases 
                 9.4e-118 
                 338.0 
               
               
                 501 
                 PHD 
                 PHD-finger 
                 0.01 
                 8.3 
               
               
                 504 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 1.3e-19 
                 78.6 
               
               
                 506 
                 rvt 
                 Reverse transcriptase (RNA-dependent DNA polymerase) 
                 3.2e-30 
                 113.8 
               
               
                 508 
                 Insulin 
                 Insulin/IGF/Relaxin family 
                 6.6e-22 
                 86.2 
               
               
                 510 
                 COX5A 
                 Cytochrome c oxidase subunit Va 
                 1.2e-55 
                 198.3 
               
               
                 511 
                 Guanylate_kin 
                 Guanylate kinase 
                 6.2e-38 
                 139.4 
               
               
                 513 
                 hexokinase 
                 Hexokinase 
                 0 
                 1029.0 
               
               
                 516 
                 trypsin 
                 Trypsin 
                 1.4e-78 
                 250.0 
               
               
                 519 
                 Glycos_transf_1 
                 Glycosyl transferases group 1 
                 2.2e-27 
                 102.8 
               
               
                 520 
                 EMP24_GP25L 
                 emp24/gp25L/p24 family 
                 3.5e-70 
                 246.6 
               
               
                 521 
                 EMP24_GP25L 
                 emp24/gp25L/p24 family 
                 3.5e-81 
                 283.1 
               
               
                 522 
                 14-3-3 
                 14-3-3 proteins 
                 6.6e-150 
                 511.4 
               
               
                 526 
                 zf-CCCH 
                 Zinc finger C-x8-C-x5-C-x3-H type (and similar). 
                 0.039 
                 13.4 
               
               
                 527 
                 SpoU_methylase 
                 SpoU rRNA Methylase family 
                 2.1e-27 
                 104.5 
               
               
                 529 
                 MMR_HSR1 
                 GTPase of unknown function 
                 1.5e-90 
                 314.2 
               
               
                 531 
                 RNase PH 
                 3′ exoribonuclease family 
                 2.2e-96 
                 333.6 
               
               
                 534 
                 COLFI 
                 Fibrillar collagen C-terminal domain 
                 5.6e-50 
                 129.2 
               
               
                 535 
                 COLFI 
                 Fibrillar collagen C-terminal domain 
                 3.1e-58 
                 150.3 
               
               
                 536 
                 CH 
                 Calponin homology (CH) domain 
                 5.6e-14 
                 59.9 
               
               
                 541 
                 FH2 
                 Formin Homology 2 Domain 
                 4.5e-07 
                 −23.3 
               
               
                 542 
                 AAA 
                 ATPases associated with various cellular activities (AAA) 
                 5.5e-33 
                 123.0 
               
               
                 547 
                 lectin_c 
                 Lectin C-type domain 
                 2.3e-29 
                 111.0 
               
               
                 551 
                 DEAD 
                 DEAD/DEAH box helicase 
                 9.2e-58 
                 185.6 
               
               
                 554 
                 C2 
                 C2 domain 
                 1.3e-51 
                 184.9 
               
               
                 555 
                 ank 
                 Ank repeat 
                 1.5e-26 
                 101.6 
               
               
                 556 
                 ank 
                 Ank repeat 
                   6e-137 
                 468.4 
               
               
                 559 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 1.1e-10 
                 38.9 
               
               
                 560 
                 ig 
                 Immunoglobulin domain 
                 1.2e-81 
                 268.2 
               
               
                 562 
                 COesterase 
                 Carboxylesterases 
                 1.4e-15 
                 55.8 
               
               
                 564 
                 FYVE 
                 FYVE zinc finger 
                 3.8e-15 
                 58.7 
               
               
                 572 
                 SPRY 
                 SPRY domain 
                 0.0059 
                 2.8 
               
               
                 573 
                 LRR 
                 Leucine Rich Repeat 
                 0.0076 
                 22.9 
               
               
                 575 
                 Skp1 
                 Skp1 family 
                 6.3e-10 
                 46.4 
               
               
                 576 
                 RhoGAP 
                 RhoGAP domain 
                 4.2e-31 
                 116.8 
               
               
                 577 
                 UQ_con 
                 Ubiquitin-conjugating enzyme 
                 6.3e-50 
                 179.3 
               
               
                 579 
                 LRR 
                 Leucine Rich Repeat 
                 8.7e-34 
                 125.7 
               
               
                 580 
                 K_tetra 
                 K+ channel tetramerisation domain 
                 0.0016 
                 −5.0 
               
               
                 581 
                 RCC1 
                 Regulator of chromosome condensation (RCC1) 
                 8.1e-10 
                 39.5 
               
               
                 582 
                 profilin 
                 Profilins 
                 5.4e-63 
                 222.7 
               
               
                 583 
                 profilin 
                 Profilins 
                   4e-48 
                 173.3 
               
               
                 585 
                 PHD 
                 PHD-finger 
                 0.041 
                 2.8 
               
               
                 586 
                 kinesin 
                 Kinesin motor domain 
                 5.2e-114 
                 392.2 
               
               
                 588 
                 aminotran_3 
                 Aminotransferases class-III pyridoxal-phosphate 
                   4e-75 
                 217.6 
               
               
                 593 
                 TPR 
                 TPR Domain 
                 0.00036 
                 27.3 
               
               
                 594 
                 PCMT 
                 Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT) 
                 1.6e-11 
                 21.8 
               
               
                 597 
                 homeobox 
                 Homeobox domain 
                 6.1e-27 
                 102.9 
               
               
                 598 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 6.8e-85 
                 295.5 
               
               
                 599 
                 Ribosomal_S5 
                 Ribosomal protein S5 
                 9.9e-12 
                 45.7 
               
               
                 600 
                 IQ 
                 IQ calmodulin-binding motif 
                 1.8e-18 
                 74.8 
               
               
                 604 
                 DUF6 
                 Integral membrane protein DUF6 
                 0.083 
                 9.1 
               
               
                 605 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 2.1e-05 
                 31.4 
               
               
                 606 
                 F-box 
                 F-box domain. 
                 1.7e-05 
                 31.7 
               
               
                 607 
                 Ran_BP1 
                 RanBP1 domain. 
                 1.1e-88 
                 308.0 
               
               
                 608 
                 actin 
                 Actin 
                 4.4e-156 
                 513.5 
               
               
                 611 
                 GTP_EFTU 
                 Elongation factor Tu family 
                 8.5e-22 
                 76.1 
               
               
                 619 
                 carb_anhydrase 
                 Eukaryotic-type carbonic anhydrase 
                 2.5e-171 
                 582.6 
               
               
                 620 
                 peroxidase 
                 Peroxidase 
                 5.8e-208 
                 704.3 
               
               
                 621 
                 FAD_Gly3P_dh 
                 FAD-dependent glycerol-3-phosphate dehydrogenase 
                 0.029 
                 −256.0 
               
               
                 623 
                 CH 
                 Calponin homology (CH) domain 
                 1.4e-25 
                 98.4 
               
               
                 625 
                 mutT 
                 Bacterial 
                 4.3e-09 
                 36.9 
               
               
                 626 
                 HECT 
                 HECT-domain (ubiquitin-transferase). 
                 4.3e-16 
                 66.9 
               
               
                 627 
                 ig 
                 Immunoglobulin domain 
                 0.024 
                 12.6 
               
               
                 631 
                 Acetyltransf 
                 Acetyltransferase (GNAT) family 
                 2.9e-12 
                 54.2 
               
               
                 632 
                 Acetyltransf 
                 Acetyltransferase (GNAT) family 
                 2.9e-12 
                 54.2 
               
               
                 634 
                 pyr_redox 
                 Pyridine nucleotide-disulphide oxidoreductase 
                 2.9e-05 
                 20.5 
               
               
                 639 
                 Sm 
                 Sm protein 
                 1.3e-07 
                 38.7 
               
               
                 640 
                 PDZ 
                 PDZ domain (Also known as DHR or GLGF). 
                 8.1e-15 
                 62.7 
               
               
                 643 
                 Syntaxin 
                 Syntaxin 
                 2.3e-09 
                 38.1 
               
               
                 645 
                 DnaJ 
                 DnaJ domain 
                 1.3e-39 
                 145.1 
               
               
                 646 
                 HMG_box 
                 HMG (high mobility group) box 
                 2.7e-27 
                 104.1 
               
               
                 650 
                 HMG_box 
                 HMG (high mobiiity group) box 
                 3.4e-30 
                 113.7 
               
               
                 653 
                 DUF6 
                 Integral membrane protein DUF6 
                   3e-12 
                 54.1 
               
               
                 654 
                 FF 
                 FF domain 
                 1.2e-33 
                 125.2 
               
               
                 655 
                 FF 
                 FF domain 
                 1.2e-33 
                 125.2 
               
               
                 658 
                 aminotran_5 
                 Aminotransferases class-V 
                 1.3e-127 
                 437.3 
               
               
                 659 
                 aminotran_5 
                 Aminotransferases class-V 
                 3.5e-94 
                 326.3 
               
               
                 666 
                 SAM_PNT 
                 Sterile alpha motif (SAM)/Pointed domain 
                 0.0021 
                 6.9 
               
               
                 667 
                 DUF52 
                 Protein of unknown function DUF52 
                 4.7e-64 
                 226.2 
               
               
                 668 
                 C2 
                 C2 domain 
                 6.8e-36 
                 132.7 
               
               
                 669 
                 C2 
                 C2 domain 
                 7.8e-35 
                 129.2 
               
               
                 671 
                 7tm_1 
                 7 transmembrane receptor (rhodopsin family) 
                 2.4e-50 
                 162.1 
               
               
                 672 
                 K_tetra 
                 K+ channel tetramerisation domain 
                 1.1e-25 
                 98.7 
               
               
                 675 
                 cyclin 
                 Cyclin 
                 7.1e-14 
                 52.2 
               
               
                 676 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 1.4e-18 
                 75.2 
               
               
                 679 
                 PDZ 
                 PDZ domain (Also known as DHR or GLGF). 
                 4.3e-16 
                 66.9 
               
               
                 681 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 1.7e-47 
                 171.2 
               
               
                 689 
                 Gelsolin 
                 Gelsolin repeat. 
                 8.5e-89 
                 308.4 
               
               
                 691 
                 TBC 
                 TBC domain 
                   2e-08 
                 15.3 
               
               
                 692 
                 TBC 
                 TBC domain 
                   2e-07 
                 1.3 
               
               
                 697 
                 GTP_CDC 
                 Cell division protein 
                 2.3e-14 
                 54.4 
               
               
                 698 
                 transmembrane4 
                 Transmembrane 4 family 
                   1e-38 
                 126.8 
               
               
                 705 
                 Colipase 
                 Colipase 
                 4.9e-21 
                 83.3 
               
               
                 706 
                 SH2 
                 Src homology domain 2 
                 1.9e-05 
                 19.4 
               
               
                 710 
                 SUI1 
                 Translation initiation factor SUI1 
                   5e-48 
                 173.0 
               
               
                 715 
                 SH3 
                 SH3 domain 
                 0.013 
                 8.0 
               
               
                 716 
                 UBA 
                 UBA domain 
                 1.3e-09 
                 45.4 
               
               
                 717 
                 Ribosomal_S21 
                 Ribosomal protein S21 
                 0.0039 
                 11.7 
               
               
                 718 
                 transmembrane4 
                 Transmembrane 4 family 
                 3.6e-52 
                 169.8 
               
               
                 723 
                 LRR 
                 Leucine Rich Repeat 
                 1.1e-48 
                 175.2 
               
               
                 724 
                 UCH-2 
                 Ubiquitin carboxyl-terminal hydrolase family 2 
                 5.6e-28 
                 106.4 
               
               
                 725 
                 F-box 
                 F-box domain. 
                 0.0016 
                 25.1 
               
               
                 727 
                 FGGY 
                 FGGY family of carbohydrate kinases 
                 5.8e-62 
                 219.3 
               
               
                 732 
                 pyr_redox 
                 Pyridine nucleotide-disulphide oxidoreductase 
                 4.2e-23 
                 80.9 
               
               
                 733 
                 WD40 
                 WD domain, G-beta repeat 
                 0.073 
                 19.6 
               
               
                 735 
                 Ribosomal_L44 
                 Ribosomal protein L44 
                   1e-38 
                 142.1 
               
               
                 738 
                 WD40 
                 WD domain, G-beta repeat 
                 1.3e-08 
                 42.1 
               
               
                 742 
                 dCMP_cyt_deam 
                 Cytidine and deoxycytidylate deaminase zinc-binding region 
                 1.7e-09 
                 45.0 
               
               
                 743 
                 gntR 
                 Bacterial regulatory proteins, gntR family 
                 0.062 
                 11.4 
               
               
                 744 
                 cpn60_TCP1 
                 TCP-1/cpn60 chaperonin family 
                 2.9e-74 
                 260.1 
               
               
                 748 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 6.5e-15 
                 63.0 
               
               
                 751 
                 VHS 
                 VHS domain 
                 1.7e-61 
                 217.7 
               
               
                 752 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 4.2e-23 
                 90.2 
               
               
                 753 
                 ank 
                 Ank repeat 
                 1.4e-80 
                 281.1 
               
               
                 757 
                 cyclin 
                 Cyclin 
                 0.026 
                 11.5 
               
               
                 761 
                 SH2 
                 Src homology domain 2 
                 5.6e-05 
                 18.0 
               
               
                 762 
                 abhydrolase 
                 alpha/beta hydrolase fold 
                 1.2e-21 
                 85.3 
               
               
                 763 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 1.8e-05 
                 22.0 
               
               
                 764 
                 WD40 
                 WD domain, G-beta repeat 
                   1e-05 
                 32.4 
               
               
                 766 
                 Acyltransferase 
                 Acyltransferase 
                 0.00021 
                 15.9 
               
               
                 771 
                 helicase_C 
                 Helicases conserved C-terminal domain 
                 3e-15 
                 64.1 
               
               
                 772 
                 Na_Ca_Ex 
                 Sodium/calcium exchanger protein 
                   8e-76 
                 265.3 
               
               
                 773 
                 vwa 
                 von Willebrand factor type A domain 
                 9.6e-29 
                 108.9 
               
               
                 775 
                 DEAD 
                 DEAD/DEAH box helicase 
                 0.042 
                 9.5 
               
               
                 776 
                 pkinase 
                 Eukaryotic protein kinase domain 
                 1.6e-07 
                 31.0 
               
               
                 780 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 1.1e-05 
                 32.3 
               
               
                 782 
                 PX 
                 PX domain 
                 1.5e-23 
                 91.7 
               
               
                 783 
                 PMP22_Claudin 
                 PMP-22/EMP/MP20/Claudin family 
                 1.5e-56 
                 201.3 
               
               
                 785 
                 homeobox 
                 Homeobox domain 
                 0.00021 
                 23.9 
               
               
                 786 
                 homeobox 
                 Homeobox domain 
                 0.00021 
                 23.9 
               
               
                 790 
                 efhand 
                 EF hand 
                 3.6e-18 
                 73.8 
               
               
                 793 
                 Glyco_hydro_31 
                 Glycosyl hydrolases family 31 
                 9.8e-18 
                 62.0 
               
               
                 797 
                 Smr 
                 Smr domain 
                 0.0029 
                 13.0 
               
               
                 798 
                 Smr 
                 Smr domain 
                 0.0029 
                 13.0 
               
               
                 799 
                 mito_carr 
                 Mitochondrial carrier proteins 
                 3.1e-61 
                 212.8 
               
               
                 801 
                 Oxysterol_BP 
                 Oxysterol-binding protein 
                 3.4e-78 
                 273.2 
               
               
                 803 
                 lipoxygenase 
                 Lipoxygenase 
                 1.7e-140 
                 480.2 
               
               
                 805 
                 Rho_GDI 
                 RHO protein GDP dissociation inhibitor 
                 1.1e-122 
                 420.9 
               
               
                 809 
                 homeobox 
                 Homeobox domain 
                 3.9e-32 
                 120.2 
               
               
                 810 
                 lipocalin 
                 Lipocalin/cytosolic fatty-acid binding protein family 
                 8.5e-31 
                 110.2 
               
               
                 811 
                 ig 
                 Immunoglobulin domain 
                 8.8e-14 
                 49.5 
               
               
                 814 
                 Keratin_B2 
                 Keratin, high sulfur B2 protein 
                 3.3e-07 
                 32.9 
               
               
                 815 
                 sugar_tr 
                 Sugar (and other) transporter 
                 0.0057 
                 −109.4 
               
               
                 817 
                 VPS9 
                 Vacuolar sorting protein 9 (VPS9) domain 
                 1.1e-37 
                 138.7 
               
               
                 818 
                 SSF 
                 Sodium:solute symporter family 
                 5.9e-206 
                 697.6 
               
               
                 819 
                 Peptidase_M3 
                 Peptidase family M3 
                 1.4e-280 
                 945.5 
               
               
                 820 
                 RasGAP 
                 GTPase-activator protein for Ras-like GRPase 
                 1.3e-26 
                 101.9 
               
               
                 824 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                   2e-87 
                 303.9 
               
               
                 825 
                 ATP-synt_C 
                 ATP synthase subunit C 
                 5.4e-08 
                 40.0 
               
               
                 826 
                 zf-C3HC4 
                 Zinc finger, C3HC4 type (RING finger) 
                 4.7e-13 
                 46.6 
               
               
                 827 
                 FH2 
                 Formin Homology 2 Domain 
                   9e-55 
                 195.4 
               
               
                 833 
                 SH3 
                 SH3 domain 
                 9.2e-14 
                 59.2 
               
               
                 835 
                 SET 
                 SET domain 
                 9.9e-52 
                 185.3 
               
               
                 836 
                 zf-DHHC 
                 DHHC zinc finger domain 
                 2.4e-25 
                 97.7 
               
               
                 837 
                 zf-C2H2 
                 ZinC finger, C2H2 type 
                 8.2e-14 
                 59.3 
               
               
                 840 
                 Trans_recep 
                 Transient receptor 
                 0 
                 1115.3 
               
               
                 850 
                 Ribosomal_S12 
                 Ribosomal protein S12 
                   1e-24 
                 93.8 
               
               
                 851 
                 Acyltransferase 
                 Acyltransferase 
                 7.3e-06 
                 32.2 
               
               
                 853 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 5.1e-80 
                 279.2 
               
               
                 854 
                 lectin_c 
                 Lectin C-type domain 
                 2.8e-24 
                 94.1 
               
               
                 855 
                 lectin_c 
                 Lectin C-type domain 
                 2.8e-24 
                 94.1 
               
               
                 856 
                 efhand 
                 EF hand 
                 9.7e-10 
                 45.8 
               
               
                 858 
                 LRR 
                 Leucine Rich Repeat 
                 3.1e-09 
                 44.1 
               
               
                 868 
                 filament 
                 Intermediate filament proteins 
                 0.00027 
                 20.0 
               
               
                 869 
                 MAGE 
                 MAGE family 
                 2.3e-19 
                 77.8 
               
               
                 871 
                 Hydrolase 
                 haloacid dehalogenase-like hydrolase 
                 0.00056 
                 12.6 
               
               
                 872 
                 Fe_hyd_SSU 
                 Iron hydrogenase small subunit 
                 0.00025 
                 21.9 
               
               
                 873 
                 filament 
                 Intermediate filament proteins 
                 3.7e-143 
                 489.0 
               
               
                 874 
                 Keratin_B2 
                 Keratin, high sulfur B2 protein 
                 0.082 
                 −51.3 
               
               
                 876 
                 metalthio 
                 Metallothionein 
                 4.7e-23 
                 90.0 
               
               
                 877 
                 C2 
                 C2 domain 
                 4.7e-53 
                 189.7 
               
               
                 880 
                 efhand 
                 EF hand 
                 0.041 
                 20.5 
               
               
                 885 
                 EGF 
                 EGF-like domain 
                 1.1e-32 
                 122.0 
               
               
                 886 
                 7tm_1 
                 7 transmembrane receptor (rhodopsin family) 
                 0.003 
                 12.5 
               
               
                 887 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 0.058 
                 15.6 
               
               
                 888 
                 Kelch 
                 Kelch motif 
                 5.3e-22 
                 86.5 
               
               
                 889 
                 tsp_1 
                 Thrombospondin type 1 domain 
                 0.0014 
                 23.3 
               
               
                 890 
                 adh_zinc 
                 Zinc-binding dehydrogenases 
                 1.5e-55 
                 197.9 
               
               
                 891 
                 pkinase 
                 Eukaryotic protein kinase domain 
                   3e-05 
                 22.8 
               
               
                 893 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 2.1e-30 
                 114.5 
               
               
                 895 
                 V_ATPase_sub_a 
                 V-type ATPase 116kDa subunit family 
                 0 
                 1263.1 
               
               
                 896 
                 aa_permeases 
                 Amino acid permease 
                 5.6e-08 
                 −125.3 
               
               
                 900 
                 MCT 
                 Monocarboxylate transporter 
                   1e-42 
                 155.3 
               
               
                 901 
                 Filamin 
                 Filamin/ABP280 repeat. 
                 2.3e-20 
                 81.1 
               
               
                 905 
                 ank 
                 Ank repeat 
                 3.3e-88 
                 306.5 
               
               
                 906 
                 ras 
                 Ras family 
                 1.4e-13 
                 17.8 
               
               
                 907 
                 Acyltransferase 
                 Acyltransferase 
                 6.4e-34 
                 126.1 
               
               
                 908 
                 wap 
                 WAP-type (Whey Acidic Protein) ‘four-disulfide core’ 
                 0.039 
                 7.8 
               
               
                 909 
                 arf 
                 ADP-ribosylation factor family 
                 3.7e-11 
                 25.6 
               
               
                 910 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 2.5e-09 
                 44.4 
               
               
                 911 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 5.6e-20 
                 79.8 
               
               
                 912 
                 BTB 
                 BTB/POZ domain 
                 1.1e-27 
                 105.4 
               
               
                 913 
                 SNF2_N 
                 SNF2 and others N-terminal domain 
                 1.7e-71 
                 250.9 
               
               
                 914 
                 ras 
                 Ras family 
                 2.4e-69 
                 243.8 
               
               
                 916 
                 rrm 
                 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 
                 0.061 
                 15.4 
               
               
                 919 
                 T-box 
                 T-box 
                 2.7e-45 
                 159.8 
               
               
                 923 
                 PH 
                 PH domain 
                 1.5e-14 
                 57.0 
               
               
                 924 
                 isodh 
                 Isocitrate and isopropylmalate dehydrogenases 
                 3.7e-125 
                 421.5 
               
               
                 925 
                 ank 
                 Ank repeat 
                 2.5e-08 
                 41.1 
               
               
                 926 
                 ank 
                 Ank repeat 
                 2.5e-08 
                 41.1 
               
               
                 928 
                 DUF51 
                 Protein of unknown function DUF51 
                 5.7e-13 
                 52.5 
               
               
                 929 
                 zf-C2H2 
                 Zinc finger, C2H2 type 
                 2.1e-72 
                 253.9 
               
               
                 930 
                 AAA 
                 ATPases associated with various cellular activities (AAA) 
                 1.1e-67 
                 238.3 
               
               
                 931 
                 SSF 
                 Sodium:solute symporter family 
                 4.8e-170 
                 578.3 
               
               
                 932 
                 SSF 
                 Sodium:solute symporter family 
                 1.3e-198 
                 673.2 
               
               
                 934 
                 aminotran_1 
                 Aminotransferases class-I 
                 2e-10 
                 10.6 
               
               
                 935 
                 DSPc 
                 Dual specificity phosphatase, catalytic domain 
                 1.1e-29 
                 112.1 
               
               
                 936 
                 ig 
                 Immunoglobulin domain 
                 2.7e-15 
                 54.3 
               
               
                 937 
                 MCM 
                 MCM2/3/5 family 
                 1.9e-11 
                 −67.4 
               
               
                 938 
                 Kelch 
                 Kelch motif 
                 5.7e-56 
                 199.4 
               
               
                 939 
                 UBA 
                 UBA domain 
                 2.7e-06 
                 34.3 
               
               
                 940 
                 UBA 
                 UBA domain 
                 2.7e-06 
                 34.3 
               
               
                 941 
                 UBA 
                 UBA domain 
                 2.7e-06 
                 34.3 
               
               
                 942 
                 Na_H_Exchanger 
                 Sodium/hydrogen exchanger family 
                 0.00067 
                 −108.1 
               
               
                 943 
                 Acyl-CoA_hydro 
                 Cytosolic long-chain acyl-CoA thioester hydrolase 
                   9e-74 
                 258.5 
               
               
                 944 
                 zf-DHHC 
                 DHHC zinc finger domain 
                 8.6e-18 
                 72.5 
               
               
                 945 
                 filament 
                 Intermediate filament proteins 
                 5.6e-29 
                 109.7 
               
               
                 946 
                 SPRY 
                 SPRY domain 
                 0.022 
                 −3.0 
               
               
                 947 
                 dsrm 
                 Double-stranded RNA binding motif 
                 1.5e-12 
                 55.1 
               
               
                 948 
                 SPRY 
                 SPRY domain 
                 2.8e-11 
                 50.9 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 5 
               
               
                   
               
               
                   
                 POSITION 
                   
                   
               
               
                   
                 OF SIGNAL 
                 maxS 
                   
               
               
                   
                 IN AMINO ACID 
                 (MAXIMUM 
                 meanS 
               
               
                 SEQ ID NO: 
                 SEQUENCE 
                 SCORE) 
                 (MEAN SCORE) 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 1 
                 1-24 
                 0.926 
                 0.738 
               
               
                 8 
                 1-48 
                 0.994 
                 0.655 
               
               
                 9 
                 1-31 
                 0.984 
                 0.921 
               
               
                 11 
                 1-36 
                 0.994 
                 0.757 
               
               
                 12 
                 1-20 
                 0.977 
                 0.902 
               
               
                 16 
                 1-25 
                 0.921 
                 0.787 
               
               
                 17 
                 1-33 
                 0.967 
                 0.803 
               
               
                 22 
                 1-26 
                 0.949 
                 0.664 
               
               
                 24 
                 1-28 
                 0.929 
                 0.700 
               
               
                 26 
                 1-17 
                 0.919 
                 0.828 
               
               
                 31 
                 1-19 
                 0.890 
                 0.552 
               
               
                 33 
                 1-19 
                 0.981 
                 0.916 
               
               
                 35 
                 1-21 
                 0.980 
                 0.904 
               
               
                 36 
                 1-21 
                 0.980 
                 0.904 
               
               
                 38 
                 1-26 
                 0.951 
                 0.801 
               
               
                 41 
                 1-43 
                 0.994 
                 0.659 
               
               
                 44 
                 1-19 
                 0.942 
                 0.693 
               
               
                 52 
                 1-21 
                 0.989 
                 0.925 
               
               
                 57 
                 1-18 
                 0.964 
                 0.812 
               
               
                 58 
                 1-19 
                 0.972 
                 0.915 
               
               
                 59 
                 1-24 
                 0.997 
                 0.929 
               
               
                 60 
                 1-16 
                 0.945 
                 0.737 
               
               
                 61 
                 1-31 
                 0.957 
                 0.775 
               
               
                 68 
                 1-28 
                 0.988 
                 0.938 
               
               
                 69 
                 1-23 
                 0.976 
                 0.897 
               
               
                 72 
                 1-33 
                 0.948 
                 0.776 
               
               
                 75 
                 1-31 
                 0.991 
                 0.925 
               
               
                 76 
                 1-41 
                 0.942 
                 0.703 
               
               
                 77 
                 1-36 
                 0.910 
                 0.749 
               
               
                 79 
                 1-27 
                 0.962 
                 0.696 
               
               
                 82 
                 1-24 
                 0.943 
                 0.832 
               
               
                 86 
                 1-27 
                 0.962 
                 0.856 
               
               
                 87 
                 1-19 
                 0.967 
                 0.909 
               
               
                 88 
                 1-39 
                 0.986 
                 0.922 
               
               
                 89 
                 1-28 
                 0.982 
                 0.924 
               
               
                 91 
                 1-29 
                 0.984 
                 0.763 
               
               
                 92 
                 1-22 
                 0.974 
                 0.796 
               
               
                 93 
                 1-29 
                 0.928 
                 0.725 
               
               
                 94 
                 1-44 
                 0.995 
                 0.811 
               
               
                 95 
                 1-36 
                 0.901 
                 0.766 
               
               
                 97 
                 1-25 
                 0.921 
                 0.787 
               
               
                 103 
                 1-23 
                 0.966 
                 0.812 
               
               
                 106 
                 1-19 
                 0.951 
                 0.895 
               
               
                 107 
                 1-16 
                 0.927 
                 0.827 
               
               
                 108 
                 1-25 
                 0.949 
                 0.823 
               
               
                 110 
                 1-28 
                 0.980 
                 0.848 
               
               
                 113 
                 1-24 
                 0.965 
                 0.891 
               
               
                 114 
                 1-25 
                 0.946 
                 0.860 
               
               
                 119 
                 1-36 
                 0.964 
                 0.648 
               
               
                 126 
                 1-32 
                 0.941 
                 0.669 
               
               
                 128 
                 1-17 
                 0.995 
                 0.974 
               
               
                 135 
                 1-18 
                 0.968 
                 0.799 
               
               
                 141 
                 1-24 
                 0.882 
                 0.599 
               
               
                 143 
                 1-38 
                 0.991 
                 0.904 
               
               
                 146 
                 1-29 
                 0.963 
                 0.888 
               
               
                 148 
                 1-19 
                 0.892 
                 0.715 
               
               
                 153 
                 1-34 
                 0.921 
                 0.652 
               
               
                 154 
                 1-20 
                 0.951 
                 0.839 
               
               
                 158 
                 1-31 
                 0.921 
                 0.659 
               
               
                 162 
                 1-36 
                 0.992 
                 0.917 
               
               
                 176 
                 1-30 
                 0.989 
                 0.910 
               
               
                 177 
                 1-28 
                 0.974 
                 0.851 
               
               
                 179 
                 1-25 
                 0.937 
                 0.812 
               
               
                 182 
                 1-30 
                 0.978 
                 0.786 
               
               
                 183 
                 1-27 
                 0.987 
                 0.879 
               
               
                 185 
                 1-23 
                 0.923 
                 0.655 
               
               
                 196 
                 1-28 
                 0.980 
                 0.893 
               
               
                 199 
                 1-27 
                 0.963 
                 0.833 
               
               
                 202 
                 1-24 
                 0.976 
                 0.913 
               
               
                 203 
                 1-24 
                 0.988 
                 0.967 
               
               
                 204 
                 1-22 
                 0.968 
                 0.831 
               
               
                 206 
                 1-21 
                 0.952 
                 0.822 
               
               
                 207 
                 1-42 
                 0.939 
                 0.682 
               
               
                 209 
                 1-22 
                 0.984 
                 0.928 
               
               
                 210 
                 1-22 
                 0.984 
                 0.928 
               
               
                 217 
                 1-21 
                 0.942 
                 0.713 
               
               
                 219 
                 1-18 
                 0.922 
                 0.838 
               
               
                 222 
                 1-18 
                 0.988 
                 0.944 
               
               
                 226 
                 1-18 
                 0.975 
                 0.958 
               
               
                 227 
                 1-18 
                 0.975 
                 0.958 
               
               
                 228 
                 1-18 
                 0.975 
                 0.958 
               
               
                 229 
                 1-48 
                 0.989 
                 0.889 
               
               
                 230 
                 1-23 
                 0.996 
                 0.936 
               
               
                 232 
                 1-16 
                 0.967 
                 0.933 
               
               
                 245 
                 1-15 
                 0.948 
                 0.907 
               
               
                 247 
                 1-27 
                 0.936 
                 0.689 
               
               
                 248 
                 1-42 
                 0.978 
                 0.750 
               
               
                 249 
                 1-15 
                 0.977 
                 0.966 
               
               
                 251 
                 1-26 
                 0.976 
                 0.875 
               
               
                 252 
                 1-28 
                 0.973 
                 0.822 
               
               
                 253 
                 1-28 
                 0.990 
                 0.925 
               
               
                 257 
                 1-22 
                 0.982 
                 0.933 
               
               
                 258 
                 1-15 
                 0.986 
                 0.919 
               
               
                 259 
                 1-27 
                 0.994 
                 0.900 
               
               
                 267 
                 1-21 
                 0.989 
                 0.871 
               
               
                 272 
                 1-28 
                 0.976 
                 0.653 
               
               
                 278 
                 1-20 
                 0.987 
                 0.916 
               
               
                 281 
                 1-30 
                 0.996 
                 0.894 
               
               
                 282 
                 1-41 
                 0.983 
                 0.791 
               
               
                 286 
                 1-20 
                 0.978 
                 0.893 
               
               
                 291 
                 1-17 
                 0.953 
                 0.784 
               
               
                 292 
                 1-25 
                 0.950 
                 0.897 
               
               
                 293 
                 1-20 
                 0.974 
                 0.912 
               
               
                 294 
                 1-15 
                 0.974 
                 0.817 
               
               
                 299 
                 1-35 
                 0.973 
                 0.795 
               
               
                 302 
                 1-22 
                 0.982 
                 0.872 
               
               
                 303 
                 1-18 
                 0.983 
                 0.927 
               
               
                 306 
                 1-20 
                 0.934 
                 0.828 
               
               
                 307 
                 1-16 
                 0.952 
                 0.807 
               
               
                 308 
                 1-19 
                 0.904 
                 0.656 
               
               
                 312 
                 1-35 
                 0.957 
                 0.640 
               
               
                 313 
                 1-35 
                 0.957 
                 0.640 
               
               
                 315 
                 1-33 
                 0.953 
                 0.707 
               
               
                 316 
                 1-24 
                 0.981 
                 0.884 
               
               
                 317 
                 1-24 
                 0.987 
                 0.914 
               
               
                 318 
                 1-21 
                 0.977 
                 0.905 
               
               
                 319 
                 1-24 
                 0.978 
                 0.911 
               
               
                 320 
                 1-18 
                 0.984 
                 0.958 
               
               
                 321 
                 1-18 
                 0.984 
                 0.958 
               
               
                 322 
                 1-24 
                 0.989 
                 0.922 
               
               
                 323 
                 1-18 
                 0.984 
                 0.956 
               
               
                 324 
                 1-18 
                 0.986 
                 0.965 
               
               
                 325 
                 1-18 
                 0.986 
                 0.965 
               
               
                 326 
                 1-32 
                 0.956 
                 0.706 
               
               
                 329 
                 1-48 
                 0.983 
                 0.616 
               
               
                 330 
                 1-20 
                 0.965 
                 0.878 
               
               
                 334 
                 1-16 
                 0.921 
                 0.828 
               
               
                 335 
                 1-20 
                 0.937 
                 0.700 
               
               
                 345 
                 1-19 
                 0.995 
                 0.971 
               
               
                 346 
                 1-19 
                 0.995 
                 0.971 
               
               
                 348 
                 1-20 
                 0.926 
                 0.751 
               
               
                 354 
                 1-29 
                 0.981 
                 0.937 
               
               
                 362 
                 1-27 
                 0.977 
                 0.849 
               
               
                 366 
                 1-24 
                 0.977 
                 0.845 
               
               
                 367 
                 1-23 
                 0.990 
                 0.833 
               
               
                 369 
                 1-25 
                 0.971 
                 0.894 
               
               
                 370 
                 1-16 
                 0.961 
                 0.916 
               
               
                 371 
                 1-41 
                 0.980 
                 0.681 
               
               
                 379 
                 1-17 
                 0.977 
                 0.921 
               
               
                 380 
                 1-17 
                 0.977 
                 0.921 
               
               
                 381 
                 1-26 
                 0.993 
                 0.894 
               
               
                 383 
                 1-25 
                 0.986 
                 0.939 
               
               
                 385 
                 1-33 
                 0.977 
                 0.811 
               
               
                 392 
                 1-43 
                 0.992 
                 0.943 
               
               
                 393 
                 1-20 
                 0.943 
                 0.882 
               
               
                 395 
                 1-20 
                 0.995 
                 0.933 
               
               
                 396 
                 1-26 
                 0.938 
                 0.663 
               
               
                 398 
                 1-21 
                 0.955 
                 0.767 
               
               
                 399 
                 1-19 
                 0.920 
                 0.692 
               
               
                 400 
                 1-41 
                 0.937 
                 0.604 
               
               
                 401 
                 1-41 
                 0.937 
                 0.604 
               
               
                 405 
                 1-19 
                 0.986 
                 0.961 
               
               
                 409 
                 1-41 
                 0.923 
                 0.559 
               
               
                 411 
                 1-25 
                 0.973 
                 0.853 
               
               
                 413 
                 1-20 
                 0.935 
                 0.817 
               
               
                 416 
                 1-29 
                 0.958 
                 0.637 
               
               
                 417 
                 1-23 
                 0.991 
                 0.740 
               
               
                 420 
                 1-29 
                 0.986 
                 0.848 
               
               
                 421 
                 1-18 
                 0.997 
                 0.979 
               
               
                 425 
                 1-16 
                 0.979 
                 0.964 
               
               
                 427 
                 1-25 
                 0.980 
                 0.952 
               
               
                 428 
                 1-37 
                 0.989 
                 0.822 
               
               
                 430 
                 1-37 
                 0.984 
                 0.878 
               
               
                 431 
                 1-42 
                 0.978 
                 0.698 
               
               
                 432 
                 1-18 
                 0.969 
                 0.913 
               
               
                 435 
                 1-31 
                 0.981 
                 0.856 
               
               
                 438 
                 1-36 
                 0.987 
                 0.595 
               
               
                 439 
                 1-27 
                 0.955 
                 0.786 
               
               
                 441 
                 1-17 
                 0.915 
                 0.825 
               
               
                 442 
                 1-34 
                 0.954 
                 0.783 
               
               
                 445 
                 1-19 
                 0.941 
                 0.839 
               
               
                 448 
                 1-27 
                 0.944 
                 0.778 
               
               
                 449 
                 1-20 
                 0.941 
                 0.734 
               
               
                 456 
                 1-22 
                 0.982 
                 0.872 
               
               
                 479 
                 1-19 
                 0.993 
                 0.931 
               
               
                 480 
                 1-22 
                 0.992 
                 0.807 
               
               
                 482 
                 1-22 
                 0.918 
                 0.716 
               
               
                 485 
                 1-38 
                 0.994 
                 0.887 
               
               
                 488 
                 1-24 
                 0.914 
                 0.588 
               
               
                 490 
                 1-28 
                 0.990 
                 0.919 
               
               
                 494 
                 1-26 
                 0.990 
                 0.969 
               
               
                 498 
                 1-36 
                 0.954 
                 0.817 
               
               
                 502 
                 1-23 
                 0.896 
                 0.747 
               
               
                 503 
                 1-23 
                 0.969 
                 0.855 
               
               
                 508 
                 1-24 
                 0.985 
                 0.932 
               
               
                 514 
                 1-23 
                 0.985 
                 0.951 
               
               
                 516 
                 1-27 
                 0.985 
                 0.927 
               
               
                 517 
                 1-21 
                 0.960 
                 0.649 
               
               
                 519 
                 1-41 
                 0.990 
                 0.922 
               
               
                 520 
                 1-20 
                 0.991 
                 0.954 
               
               
                 521 
                 1-20 
                 0.991 
                 0.954 
               
               
                 525 
                 1-21 
                 0.975 
                 0.909 
               
               
                 530 
                 1-11 
                 0.900 
                 0.758 
               
               
                 545 
                 1-18 
                 0.933 
                 0.634 
               
               
                 547 
                 1-22 
                 0.899 
                 0.639 
               
               
                 548 
                 1-40 
                 0.953 
                 0.668 
               
               
                 561 
                 1-16 
                 0.881 
                 0.607 
               
               
                 568 
                 1-36 
                 0.924 
                 0.590 
               
               
                 569 
                 1-25 
                 0.919 
                 0.718 
               
               
                 570 
                 1-28 
                 0.928 
                 0.590 
               
               
                 571 
                 1-27 
                 0.967 
                 0.872 
               
               
                 578 
                 1-25 
                 0.998 
                 0.934 
               
               
                 579 
                 1-30 
                 0.973 
                 0.829 
               
               
                 599 
                 1-20 
                 0.937 
                 0.728 
               
               
                 603 
                 1-30 
                 0.962 
                 0.801 
               
               
                 604 
                 1-17 
                 0.925 
                 0.779 
               
               
                 609 
                 1-20 
                 0.981 
                 0.910 
               
               
                 614 
                 1-17 
                 0.977 
                 0.921 
               
               
                 617 
                 1-25 
                 0.938 
                 0.677 
               
               
                 620 
                 1-22 
                 0.975 
                 0.822 
               
               
                 629 
                 1-34 
                 0.934 
                 0.552 
               
               
                 630 
                 1-28 
                 0.946 
                 0.799 
               
               
                 635 
                 1-15 
                 0.954 
                 0.725 
               
               
                 636 
                 1-30 
                 0.938 
                 0.808 
               
               
                 644 
                 1-24 
                 0.973 
                 0.910 
               
               
                 649 
                 1-24 
                 0.920 
                 0.596 
               
               
                 652 
                 1-29 
                 0.968 
                 0.769 
               
               
                 656 
                 1-28 
                 0.975 
                 0.926 
               
               
                 665 
                 1-25 
                 0.977 
                 0.776 
               
               
                 670 
                 1-41 
                 0.986 
                 0.847 
               
               
                 679 
                 1-24 
                 0.915 
                 0.578 
               
               
                 682 
                 1-24 
                 0.950 
                 0.737 
               
               
                 683 
                 1-28 
                 0.987 
                 0.785 
               
               
                 684 
                 1-19 
                 0.890 
                 0.552 
               
               
                 685 
                 1-22 
                 0.968 
                 0.934 
               
               
                 686 
                 1-22 
                 0.968 
                 0.934 
               
               
                 687 
                 1-23 
                 0.965 
                 0.883 
               
               
                 688 
                 1-23 
                 0.965 
                 0.883 
               
               
                 690 
                 1-26 
                 0.896 
                 0.615 
               
               
                 693 
                 1-30 
                 0.956 
                 0.665 
               
               
                 696 
                 1-39 
                 0.971 
                 0.694 
               
               
                 698 
                 1-44 
                 0.992 
                 0.576 
               
               
                 701 
                 1-45 
                 0.964 
                 0.657 
               
               
                 702 
                 1-45 
                 0.964 
                 0.657 
               
               
                 705 
                 1-17 
                 0.968 
                 0.947 
               
               
                 707 
                 1-28 
                 0.960 
                 0.607 
               
               
                 709 
                 1-31 
                 0.977 
                 0.720 
               
               
                 714 
                 1-28 
                 0.956 
                 0.604 
               
               
                 718 
                 1-47 
                 0.985 
                 0.646 
               
               
                 719 
                 1-19 
                 0.990 
                 0.946 
               
               
                 729 
                 1-47 
                 0.996 
                 0.556 
               
               
                 736 
                 1-18 
                 0.930 
                 0.679 
               
               
                 739 
                 1-25 
                 0.992 
                 0.948 
               
               
                 741 
                 1-26 
                 0.947 
                 0.594 
               
               
                 745 
                 1-22 
                 0.963 
                 0.859 
               
               
                 747 
                 1-26 
                 0.956 
                 0.830 
               
               
                 755 
                 1-26 
                 0.990 
                 0.959 
               
               
                 758 
                 1-40 
                 0.987 
                 0.917 
               
               
                 759 
                 1-26 
                 0.985 
                 0.917 
               
               
                 762 
                 1-36 
                 0.991 
                 0.868 
               
               
                 765 
                 1-24 
                 0.887 
                 0.553 
               
               
                 766 
                 1-23 
                 0.995 
                 0.974 
               
               
                 767 
                 1-18 
                 0.997 
                 0.977 
               
               
                 768 
                 1-22 
                 0.968 
                 0.934 
               
               
                 770 
                 1-26 
                 0.974 
                 0.730 
               
               
                 773 
                 1-18 
                 0.983 
                 0.939 
               
               
                 783 
                 1-24 
                 0.988 
                 0.919 
               
               
                 795 
                 1-30 
                 0.939 
                 0.639 
               
               
                 796 
                 1-26 
                 0.984 
                 0.746 
               
               
                 807 
                 1-23 
                 0.965 
                 0.693 
               
               
                 810 
                 1-22 
                 0.962 
                 0.919 
               
               
                 811 
                 1-21 
                 0.988 
                 0.911 
               
               
                 812 
                 1-36 
                 0.980 
                 0.559 
               
               
                 821 
                 1-10 
                 0.880 
                 0.780 
               
               
                 823 
                 1-14 
                 0.922 
                 0.678 
               
               
                 825 
                 1-39 
                 0.982 
                 0.829 
               
               
                 830 
                 1-34 
                 0.973 
                 0.817 
               
               
                 831 
                 1-36 
                 0.976 
                 0.794 
               
               
                 838 
                 1-18 
                 0.918 
                 0.651 
               
               
                 839 
                 1-35 
                 0.991 
                 0.834 
               
               
                 841 
                 1-22 
                 0.947 
                 0.677 
               
               
                 847 
                 1-24 
                 0.963 
                 0.865 
               
               
                 848 
                 1-30 
                 0.967 
                 0.758 
               
               
                 849 
                 1-33 
                 0.926 
                 0.807 
               
               
                 852 
                 1-25 
                 0.889 
                 0.718 
               
               
                 857 
                 1-20 
                 0.995 
                 0.968 
               
               
                 859 
                 1-27 
                 0.887 
                 0.642 
               
               
                 862 
                 1-41 
                 0.975 
                 0.875 
               
               
                 865 
                 1-26 
                 0.921 
                 0.620 
               
               
                 878 
                 1-36 
                 0.951 
                 0.782 
               
               
                 884 
                 1-19 
                 0.983 
                 0.888 
               
               
                 885 
                 1-23 
                 0.971 
                 0.941 
               
               
                 886 
                 1-40 
                 0.964 
                 0.560 
               
               
                 891 
                 1-39 
                 0.942 
                 0.587 
               
               
                 898 
                 1-16 
                 0.945 
                 0.737 
               
               
                 899 
                 1-24 
                 0.946 
                 0.593 
               
               
                 900 
                 1-44 
                 0.974 
                 0.662 
               
               
                 902 
                 1-26 
                 0.974 
                 0.730 
               
               
                 903 
                 1-27 
                 0.952 
                 0.832 
               
               
                 908 
                 1-25 
                 0.960 
                 0.642 
               
               
                 918 
                 1-31 
                 0.956 
                 0.846 
               
               
                 921 
                 1-16 
                 0.968 
                 0.921 
               
               
                 936 
                 1-19 
                 0.984 
                 0.936 
               
               
                 944 
                 1-35 
                 0.954 
                 0.699 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
             
           
               
                   
               
               
                 SEQUENCE LISTING 
               
             
          
           
               
                 The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO 
               
               
                 web site (http://seqdata.uspto.gov/sequence.html?DocID=06783969B1). An electronic copy of the “Sequence Listing” will also be available from the 
               
               
                 USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).