Abstract:
The objective of the invention is to enhance measurement accuracy in a device for measuring a biological sample. To attain this objective, the invention is provided with a main case ( 2 ) having a sensor insertion section ( 1 ), a measurement section ( 7 ) connected to the sensor insertion section ( 1 ), a controller ( 8 ) connected to the measurement section ( 7 ), and a display ( 3 ) connected to the controller ( 8 ). An acceleration sensor ( 5 ) is furnished for detecting a shock applied to the sensor insertion section ( 1 ).

Description:
TECHNICAL FIELD 
       [0001]    The present invention relates to a biological sample measuring apparatus, and particularly to a biological sample measuring apparatus for measuring blood glucose levels, for example. 
       BACKGROUND ART 
       [0002]    A conventionally a biological sample measuring apparatus includes a main body case having a sensor insertion section, a measurement section connected to the sensor insertion section, a control section connected to the measurement section, and a display section connected to the control section (see, PTL 1, for example). 
         [0003]    Specifically, in the conventional biological sample measuring apparatus, when blood is spotted on a blood glucose level sensor inserted in the sensor insertion section, blood glucose level is measured by a measurement section, and the measured blood glucose level is displayed on the display section. 
       CITATION LIST 
     Patent Literature 
       [0000]    
       
         PTL 1 
       
     
       WO02/044705 
     SUMMARY OF INVENTION 
     Technical Problem 
       [0005]    A problem with the conventional biological sample measuring apparatuses lies in that the measurement accuracy may be low in some cases. Specifically, in the conventional biological sample measuring apparatus, when blood is spotted on a blood glucose level sensor inserted in the sensor insertion section, the blood reaches a reaction reagent, causing electro chemical reactions. Then, by observing the states of the electrochemical reactions using the measurement section, blood glucose level is detected. However, when an impact is applied to the blood glucose level sensor after the spotting of blood on the blood glucose level sensor but before the completion of the measurement, the blood may not be allowed to smoothly reach a reagent portion, and as a result, the measurement accuracy may be lowered. 
         [0006]    Such an impact tends to be caused when separating a finger from the blood glucose level sensor at the time of spot application of blood exuded from the punctured finger on the blood glucose level sensor. Specifically, in such a situation that the blood glucose level sensor is flicked by the finger, the spotted blood fails to smoothly reach the reaction reagent because of the impact thus caused, and as a result, the measurement accuracy is lowered. 
         [0007]    Under such circumstances, an object of the present invention is to improve the measurement accuracy of a biological sample measuring apparatus. 
       Solution to Problem 
       [0008]    In order to achieve the above-mentioned object, the present invention provides a biological sample measuring apparatus including: a main body case including a sensor insertion section; a measurement section connected to the sensor insertion section; a control section connected to the measurement section; and a display section connected to the control section, wherein an acceleration sensor that detects an impact applied to the sensor insertion section is provided. Thus, the desired object is achieved. 
       Advantageous Effects of Invention 
       [0009]    With the biological sample measuring apparatus according to the present invention, the measurement accuracy can be improved. Specifically, in the present invention, for example, when an impact is applied to the sensor insertion section via the biological sample measuring sensor for measuring blood glucose levels and the like, the impact thus applied is detected by the acceleration sensor. Then, when the impact level is greater than a predetermined value, it is possible to display, on the display section, the fact that the measurement result measured by the measurement section is inadequate. Thus, inadequate measured values are not displayed, and the measurement accuracy is improved. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0010]      FIG. 1  is a perspective view of a biological sample measuring apparatus according to Embodiment 1; 
           [0011]      FIG. 2  is a sectional view of the biological sample measuring apparatus illustrated in  FIG. 1 ; 
           [0012]      FIG. 3  is a plan view of the biological sample measuring apparatus illustrated in  FIG. 1 ; 
           [0013]      FIG. 4  is a control block diagram of the biological sample measuring apparatus illustrated in  FIG. 1 ; 
           [0014]      FIG. 5  is a flowchart explanatory of a measurement in the biological sample measuring apparatus illustrated in  FIG. 1 ; 
           [0015]      FIGS. 6A to 6D  illustrate exemplary error messages displayed by the biological sample measuring apparatus illustrated in  FIG. 1 ; 
           [0016]      FIG. 7  is a plan view of a biological sample measuring apparatus according to Embodiment 2; 
           [0017]      FIG. 8  is a plan view of a biological sample measuring apparatus according to Embodiment 3; 
           [0018]      FIG. 9  is a plan view of a biological sample measuring apparatus according to Embodiment 4; 
           [0019]      FIG. 10  is a control block diagram of the biological sample measuring apparatus illustrated in  FIG. 9 ; 
           [0020]      FIG. 11  is a sectional view illustrating the inside of a biological sample measuring apparatus according to Embodiment 5; 
           [0021]      FIG. 12A  illustrates relationships between axes of a three-dimensional acceleration sensor and a biological sample measuring sensor; 
           [0022]      FIG. 12B  illustrates vector components of a measured acceleration; 
           [0023]      FIG. 12C  illustrates an exemplary waveform of a signal output from the acceleration sensor; 
           [0024]      FIG. 12D  is another exemplary waveform output from the acceleration sensor; 
           [0025]      FIG. 13  is a graph illustrating a waveform pattern of an applied voltage for use in a blood glucose level measurement in a biological sample measuring apparatus according to Embodiment 6; 
           [0026]      FIG. 14  is a graph illustrating a signal output from a detection electrode of the biological sample measuring sensor when the voltage waveform pattern illustrated in  FIG. 13  is applied thereto; 
           [0027]      FIG. 15  is a plan view of a biological sample measuring apparatus according to Embodiment 7; and 
           [0028]      FIG. 16  is a flowchart explanatory of a measurement operation including additional spotting in a biological sample measuring apparatus according to Embodiment 8. 
       
    
    
     DESCRIPTION OF EMBODIMENTS 
       [0029]    In the following, an embodiment of the present invention which is applied to a biological sample measuring apparatus for measuring blood glucose levels is described with reference to the accompanying drawings. 
       Embodiment 1 
       [0030]      FIG. 1  is a perspective view of a biological sample measuring apparatus of the present embodiment;  FIG. 2  is a sectional view thereof;  FIG. 3  is a top view thereof; and  FIG. 4  is a control block diagram thereof. As illustrated in  FIG. 1 , the biological sample measuring apparatus of the present embodiment includes main body case  2  having sensor insertion section  1  at one end thereof. In sensor insertion section  1 , sensor  11  having spot application section  11   a  is provided for insertion. 
         [0031]    Display section  3 , and operation buttons  14  and  15  are provided on the upper surface of main body case  2 . As illustrated in  FIG. 2 , sensor insertion section  1  is disposed at an end of substrate (electric circuit substrate)  4  provided in main body case  2 . In addition, acceleration sensor  5  is disposed in sensor insertion section  1  as illustrated in  FIG. 2  and  FIG. 3 . 
         [0032]    Inside sensor insertion section  1 , a connector section (not illustrated) that electrically connects with biological sample measuring sensor  11  inserted thereto is provided. When biological sample measuring sensor  11  is inserted in sensor insertion section  1 , a measurement section configured on substrate  4  and the connecting section of biological sample measuring sensor  11  are electrically connected to each other via the connector section. 
         [0033]    It is desirable that acceleration sensor  5  be disposed at a position adjacent to the connector section. Thus, acceleration sensor  5  is disposed on substrate  4  in the proximity of control device  6 ; in other words, acceleration sensor  5  is disposed on substrate  4  in the proximity of control device  6  functioning as a measurement section or control section. In addition, acceleration sensor  5  is disposed in the proximity of sensor insertion section  1 . 
         [0034]    Control device  6  which is called the microcomputer is disposed on the upper surface of substrate  4 . As illustrated in  FIG. 4 , control device  6  includes measurement section  7  connected to sensor insertion section  1 , control section  8  connected to measurement section  7 , determination section  9  connected to acceleration sensor  5 , and memory section  10  connected to determination section  9 . Determination section  9  and memory section  10  are connected to control section  8 . 
         [0035]    In addition, sensor insertion section  1  is provided with insertion detection section  12  for detecting insertion of biological sample measuring sensor  11 , and insertion detection section  12  is connected to control section  8 . Further, display section  3 , buzzer  13  as an example of alarm means, and operation buttons  14  and  15  are connected to control section  8 . 
         [0036]    The flow of measuring blood glucose levels by a biological sample measuring apparatus having the above-mentioned configuration is described with reference to  FIG. 5 . First, a basic measurement flow is described. To make measurement, firstly, biological sample measuring sensor  11  (blood glucose level sensor) is inserted in sensor insertion section  1  as illustrated in  FIG. 1 . When insertion detection section  12  detects insertion of the sensor, power source is turned on (step S 1  in  FIG. 5 ). Thereafter, blood exuded from the punctured finger is spotted on spot application section  11   a  of biological sample measuring sensor  11  in the state illustrated in  FIG. 1  (step S 5  in  FIG. 5 ). The spotted blood reaches a reagent (not illustrated) in biological sample measuring sensor  11  from spot application section  11   a , and the blood and the reagent causes electrochemical reactions. The signal of the chemical reaction thus caused is measured at measurement section  7  (S 10  in  FIG. 5 ), and the results of the measurement are displayed on display section  3  (S 12  in  FIG. 5 ). 
         [0037]    Further, in the present embodiment, whether an excessive impact is applied on sensor insertion section  1  or not is detected between the above-described steps S 1  and S 5 , and between the above-described steps S 5  and S 10 . To be more specific, at S 2  (before the measurement) and/or S 7  (during the measurement) in  FIG. 5 , an output from acceleration sensor  5  is input to determination section  9 . Then, determination section  9  determines whether or not the value of the output is equal to or greater than a predetermined value (step S 3  and/or S 8 ). When the impact determined by determination section  9  is smaller than the predetermined value, it is determined that there is no problem and the process is advanced to step S 5  or step S 10 . Meanwhile, when the impact determined by determination section  9  is equal to or greater than the predetermined value, a flag indicating that “excessive impact has been applied” is recorded in memory section  10  at step S 4  or step S 9 . 
         [0038]    After the measurement is completed at step S 10 , control section  8  determines at step S 11  whether the flag has been input to memory section  10  or not. When the flag is found, an error message is displayed on display section  3 . An error warning may also be given using buzzer  13  together with the display. 
         [0039]      FIGS. 6A to 6D  illustrate exemplary error messages to be displayed on display section  3 .  FIG. 6A  is an error message using a dot matrix pattern to illustrate the fact that an impact has been applied;  FIG. 6B  is an error message using an error code (in a case of a segment display) to illustrate the fact that an impact has been applied.  FIG. 6C  and  FIG. 6D  will be described in Embodiment 3. 
         [0040]    At the time of the spot application of blood exuded from a punctured finger on spot application section  11   a  of biological sample measuring sensor  11 , an excessive impact tends to be applied to sensor insertion section  1  when separating the finger from biological sample measuring sensor  11 . Specifically, at this time, the finger may accidentally flick spot application section  11   a  of biological sample measuring sensor  11 . Due to the impact caused by the flicking of the finger, the spotted blood is not allowed to smoothly reach a reagent portion in biological sample measuring sensor  11 . As a result, the measurement accuracy is lowered. 
         [0041]    In view of the foregoing, in the present embodiment, an excessive impact applied to sensor insertion section  1  is detected by acceleration sensor  5 . When an excessive impact is detected, an error message is displayed on display section  3 . Thus, inadequate measured values are prevented from being displayed. In this manner, the measurement accuracy is increased in the present embodiment. 
         [0042]    In the present embodiment, in order to detect an excessive impact applied to sensor insertion section  1  by acceleration sensor  5 , acceleration sensor  5  is disposed in sensor insertion section  1  as illustrated in  FIG. 3 . To be more specific, acceleration sensor  5  is mounted on substrate  4  in sensor insertion section  1 . 
         [0043]    Acceleration sensor  5  is preferably a three-dimensional acceleration sensor. Three-dimensional acceleration sensors can measure acceleration components in axial directions X, Y and Z. Therefore, when three-dimensional acceleration sensors are used, the direction and amount of the impact can be recorded, and the impact received at sensor insertion section  1  can be grasped in more detail. 
         [0044]    Examples of three-dimensional acceleration sensors (or triaxial acceleration sensors) include piezoresistive acceleration sensors, capacitive acceleration sensors, thermal detection acceleration sensors, and the like. Three-dimensional acceleration sensors are applied to mobile phones, game controllers, vibration detection of hard disks, posture control of robots, and the like. 
         [0045]    Three-dimensional piezoresistive acceleration sensors include a diaphragm which is formed by forming a thin circular surface using manufacturing technology of silicon semiconductors. In three-dimensional piezoresistive acceleration sensors, a spindle at the center is supported by the thin metal in order to readily detect the displacement caused by acceleration, the locational change of the diaphragm is detected by a piezoresistance device, and amplification and measurement are performed by an electric circuit. Three-dimensional capacitive acceleration sensors detect a slight change in position of a minute movable part supported by a beam structure as a change in capacitance, and perform amplification and measurement by using an electric circuit. Three-dimensional thermal detection acceleration sensors generate a thermal air current in an acceleration sensor housing by using a heater, and use a thermal resistance and the like to detect change of the convection caused by acceleration. 
         [0046]    The acceleration sensor used herein is a three-dimensional capacitive acceleration sensor which has a measurement range from −2 g to +2 g (g: gravitational acceleration), for example. The standard gravitational acceleration is 1.0 G=approximately 9.8 m/s 2 . 
         [0047]    Further, it is also possible to compare the impact detected by the acceleration sensor and the durability of main body case  2  and the like, and, as necessary, issue an notification to urge the user to replace the biological sample measuring apparatus as soon as possible. Here, “the durability of main body case  2 ” is a durability corresponding to the quality assurance range of the mechanical strength for the measuring apparatus, which is assessed based on a mechanical strength test of a main body case (for example, a drop test of the measuring apparatus and the like) in the quality assessment or shipping inspection of measuring apparatuses. To be more specific, the mechanical strength test is a test for determining whether the performance of the measuring apparatus is influenced by factors such as coming off of a component mounted to a substrate in the measuring apparatus, cracks in a substrate or the like, and breakage of a component itself when a drop test of the measuring apparatus as a completed product is performed (for example, a test in which an apparatus is dropped to the floor from heights of 1 m). 
       Embodiment 2 
       [0048]    As illustrated in  FIG. 7 , acceleration sensor  5  of a biological sample measuring apparatus of the present embodiment is disposed on substrate  4  inside main body case  2 . Mainly, acceleration sensor  5  disposed as described above can detect the impact applied to the entire main body case  2 . For example, an impact is possibly applied to the entire main body case  2  when main body case  2  is dropped during the measurement, or when main body case  2  is carelessly hit against surrounding objects. 
       Embodiment 3 
       [0049]    As illustrated in  FIG. 8 , a biological sample measuring apparatus of the present embodiment includes two acceleration sensors  5   a  and  5   b . Acceleration sensor  5   a  is provided at a location corresponding to sensor insertion section  1  of substrate  4  as in the case of Embodiment 1. Acceleration sensor  5   b  is provided on substrate  4  inside main body case  2  as in the case of Embodiment 2. 
         [0050]    In the present embodiment, two acceleration sensors  5   a  and  5   b  are provided at different locations, and thus the kinds of impact can be detected in detail by utilizing both of the detection results obtained by respective acceleration sensors. Consequently, the reliability of the measurement can be further increased. 
         [0051]    To be more specific, acceleration sensor  5   a  can detect the impact and the like caused by a finger flicking the biological sample measuring sensor  11  at the time of the spot application of blood on spot application section  11   a  of biological sample measuring sensor  11  installed in sensor insertion section  1 . In addition, acceleration sensor  5   a  can detect the impact applied to the entire main body case  2 . On the other hand, acceleration sensor  5   b  can detect the impact applied to the entire main body case  2  since acceleration sensor  5   b  is disposed in main body case  2  at substantially the center thereof, but acceleration sensor  5   b  is insufficient to detect the impact caused by the flicking of biological sample measuring sensor  11 . 
         [0052]    In view of the foregoing, when only acceleration sensor  5   a  has detected an impact greater than a predetermined value, it is determined that biological sample measuring sensor  11  is flicked by the user&#39;s finger at the time of the spot application. Then, the error message illustrated in  FIG. 6C  is displayed on display section  3 . Meanwhile, when each of acceleration sensors  5   a  and  5   b  has detected an impact greater than a predetermined value, it is determined that the impact is applied to the entire main body case  2 , and then the error message illustrated in  FIG. 6D  is displayed on display section  3  to call the user&#39;s attention. 
       Embodiment 4 
       [0053]    In a biological sample measuring apparatus of the present embodiment, while two acceleration sensors are incorporated as in the case of Embodiment 3, sensor insertion section  1  is detachably provided in main body case  2  as illustrated in  FIG. 9  and  FIG. 10 . Specifically, the biological sample measuring apparatus of the present embodiment includes main body case  2  provided with acceleration sensor  5   b  and install section  16 , and sensor insertion section  1  provided with acceleration sensor  5   a  and insertion detection section  12 . And sensor insertion section  1  can be detachably installed in install section  16 . 
         [0054]    As illustrated in  FIG. 9 , install section  16  is provided with connector section  16   a  having a plurality of connection terminals. As illustrated in  FIG. 10 , when sensor insertion section  1  is installed in install section  16 , signals of acceleration sensor  5   a  and insertion detection section  12  which configure sensor insertion section  1  are transmitted via connector section  16   a  to determination section  9  and control section  8  which are included in control device  6  disposed on substrate  4  in main body case  2 . 
         [0055]    When a biological sample is measured, a signal of biological sample measuring sensor  11  inserted in sensor insertion section  1  is transmitted via connector section  16   a  to measurement section  7  disposed in control device  6 . Thereafter, a biological sample (for example, blood, or the like) is measured (for example, blood glucose level is measured). 
         [0056]    Install section  16  of main body case  2  may be integrated with substrate  4 . Specifically, install section  16  may be configured in such a manner that a plurality of connection terminals configuring connector section  16   a  are provided to substrate  4  on which control device  6  is mounted. 
         [0057]    Replaceable sensor insertion section  1  may be provided with other sensors than acceleration sensor  5   a  (such as temperature sensor and humidity sensor, for example) together with acceleration sensor  5   a.    
         [0058]      FIG. 10  illustrates a control block diagram of a biological sample measuring apparatus of the present embodiment. Different from the control block of Embodiment 1 and Embodiment 2 ( FIG. 4 ), the control block illustrated in  FIG. 10  includes two acceleration sensors  5   a  and  5   b  which are connected to determination section  9  of control device  6 . A signal of acceleration sensor  5   a  is transmitted to determination section  9  via connector section  16   a . Specifically, acceleration information (output information) of acceleration sensors  5   a  and  5   b  is input to determination section  9 . 
         [0059]    Since sensor insertion section  1  is replaceable in the biological sample measuring apparatus of the present embodiment, sensor insertion section  1  can be replaced when sensor insertion section  1  and its surrounding region are contaminated (for example, in the case where blood is adhered thereto). Thus, cleaning can be easily carried out, excellent serviceability and maintainability are advantageously achieved, biological sample measuring apparatus can be kept sanitary, and as a result, improvement in reliability (for example, stable operation of biological sample measuring apparatus) is achieved. 
       Embodiment 5 
       [0060]    As illustrated in  FIG. 11 , in a biological sample measuring apparatus of the present embodiment, acceleration sensor  5   a  is provided in sensor insertion section  1 , and acceleration sensor  5   b  is provided on substrate  4 .  FIG. 11  illustrates an internal sectional view of sensor insertion section  1  and its surroundings of the biological sample measuring apparatus of the present embodiment, and illustrates a state where biological sample measuring sensor  11  is inserted in sensor insertion section  1 . A connection terminal (not illustrated) of biological sample measuring sensor  11  and contact section  21  of contact pin  20  are in contact with each other, and electrically connected to each other. It is to be noted that, in  FIG. 11 , portions corresponding to main electric circuits such as the control section are omitted for convenience. 
         [0061]    Acceleration sensor  5   a  is disposed in contact with contact pin  20 . In addition, acceleration sensor  5   a  is electrically connected to substrate  4  via wiring  29 . The distal end (connection terminal) of biological sample measuring sensor  11  inserted in sensor insertion section  1  is locked at protrusion  22 . That is, protrusion  22  functions as a stopper for biological sample measuring sensor  11 .  FIG. 11  illustrates a state where biological sample measuring sensor  11  is locked at protrusion  22 , or in other words, a state where biological sample measuring sensor  11  is appropriately set in sensor insertion section  1 . 
         [0062]    The biological sample measuring apparatus in  FIG. 8  includes acceleration sensor  5   a  which is a part of sensor insertion section  1  and is provided on substrate  4 , whereas the biological sample measuring apparatus in  FIG. 11  includes acceleration sensor  5   a  which is a part of sensor insertion section  1  and is attached so as to be in contact with contact pin  20 . 
         [0063]    When biological sample measuring sensor  11  is inserted in sensor insertion section  1 , contact pin  20  is bent in an arrow X direction. Acceleration sensor  5   a  attached in contact with contact pin  20  detects an oscillation of contact pin  20 . In this manner, the insertion of biological sample measuring sensor  11  can be detected by acceleration sensor  5   a . Likewise, the ejection of biological sample measuring sensor  11  from sensor insertion section  1  can be detected by acceleration sensor  5   a.    
         [0064]    With the above-described configuration, at the time of the spot application of blood exuded from a finger on spot application section  11   a  of biological sample measuring sensor  11 , acceleration sensor  5   a  can surely detect an impact caused when a “bending” state of biological sample measuring sensor  11  caused by the finger is forcefully cancelled, and/or an impact caused by the finger or the like making contact with biological sample measuring sensor during the measurement. When such an impact is detected, since it is highly possible that the measured value is unreliable, warning of a measurement defect can be displayed, without displaying the measured value. 
         [0065]    When an impact is received during the measurement, the reagent in biological sample measuring sensor  11  and the like move from a given position, and thus an excessively small or excessively great measured value (blood glucose level) may be obtained erroneously. When the measured value is excessively small or excessively great, an inappropriate amount of insulin may be administered, and thus an accident may be caused. In particular, if the measured value is excessively small, then insulin is administered more than necessary based on the excessively small measured value, thus causing an accident leading to hypoglycemia which is a very dangerous condition. The blood measuring apparatus of the present invention can surely prevent such a problem. 
         [0066]    After the installment of biological sample measuring sensor  11  in sensor insertion section  1  has been completed, blood or the like is spotted on spot application section  11   a  of biological sample measuring sensor  11  to start measurement. When the measurement is completed, results of the measurement are displayed on the display section. During the measurement, acceleration sensor  5   a  attached to contact pin  20  and acceleration sensor  5   b  provided on substrate  4  monitor whether an impact has been received from the outside. When an impact greater than a predetermined value is detected during the measurement, it is determined that the measured blood glucose level has a problem with the reliability. Then, without displaying the measured value, a warning indicating that “impact is caused during measurement, so measurement is failed” is displayed to urge a remeasurement. 
         [0067]    More specifically, when each of acceleration sensor  5   a  and acceleration sensor  5   b  has detected an impact greater than a predetermined value, it is determined that the measuring apparatus itself has hit something and received an impact, and a measurement error message is displayed. Then, a warning which urges a confirmation whether the measuring apparatus itself can be operated. 
         [0068]    When only acceleration sensor  5   a  has detected an impact greater than a predetermined value, it is determined that a finger or the like may have made contact with biological sample measuring sensor  11  during the measurement, and a measurement error message is displayed. Then, an attention message that urges a remeasurement and more careful operation is displayed. 
         [0069]    After the measurement of blood glucose level and the like have been completed, the used biological sample measuring sensor  11  is pinched and pulled out by hand, and discarded. The impact caused by such an ejecting operation can be detected by acceleration sensor  5   a . In this manner, acceleration sensor  5   a  can also detect both the insertion and ejection of sample measuring sensor  11 . 
         [0070]    The sensitivity of acceleration sensor  5   a  provided in sensor insertion section  1  and the sensitivity of acceleration sensor  5   b  on substrate  4  in  FIG. 11  may cover respective measurement ranges different from each other. For example, the sensitivity of acceleration sensor  5   a  is about two to ten times higher than that of acceleration sensor  5   b . As a more detailed example, it is conceivable to use an acceleration sensor covering a measurement range of −2 g to +2 g and another acceleration sensor covering a measurement range of −6 g to +6 g as acceleration sensors  5   a  and  5   b , respectively. In this manner, the impact caused by making contact with the biological sample measuring sensor during the measurement can be measured with higher sensitivity, and thus the impact detection accuracy can be improved. 
         [0071]    For the purpose of improving the reliability of measurement operation, the following threshold levels L 1  to L 3  may be set. The threshold level L 1  is a threshold level for detecting the insertion and ejection of biological sample measuring sensor  11 , and for example, may be set within the range of about 0.01 g to about 0.3 g. The threshold level L 2  is a threshold level for detecting the fact that a finger or the like has made contact with the biological sample measuring sensor during the measurement (or a threshold level for detecting a possibility that the measured value lacks reliability), and for example, may cover a range of about 0.005 g to about 0.3 g. The threshold level L 3  is a threshold level for determining that the measurement itself cannot be made, and for example, is desirably 0.5 g or more. 
         [0072]    The relationships between threshold levels L 1  to L 3  are as follows, for example. 
         [0000]      L1&lt;L3  (1)
 
         [0000]      L2&lt;L3  (2)
 
         [0000]      L1≦L2 or L1&gt;L2  (3)
 
         [0073]    Here, when the relationship between the threshold level L 1  and threshold level L 2  is set to L 1 &gt;L 2 , even an impact (acceleration) smaller than the impact (acceleration) caused at the time of insertion or ejection of biological sample measuring sensor  11  is determined to be an error, and therefore high safety can be ensured. 
         [0074]    In addition, the threshold levels L 1  to L 3  may be compared with acceleration data measured by both acceleration sensor  5   a  and acceleration sensor  5   b ; however, in terms of the purpose thereof, it is presumably more effective to compare the threshold level L 1  and threshold level L 2  mainly with acceleration data measured by acceleration sensor  5   a  provided in sensor insertion section  1 , and to compare the threshold level L 3  with acceleration data measured at acceleration sensor  5   b  provided on substrate  4 . In view of the foregoing, acceleration sensors having sensitivities different from each other may be selected for acceleration sensor  5   a  and acceleration sensor  5   b  as described above. 
         [0075]    Preferably, acceleration sensor  5   a  attached in sensor insertion section  1  (on contact pin  20  in  FIG. 11 ), and acceleration sensor  5   b  disposed on substrate  4  in the apparatus are each a three-dimensional acceleration sensor. 
         [0076]      FIG. 12A  illustrates a relationship between axes of three-dimensional acceleration sensor (X axis, Y axis, and Z axis) and the biological sample measuring sensor. In  FIG. 12A , the X axis is in parallel to the longitudinal direction of plate-shaped biological sample measuring sensor  11 , the Y axis is orthogonal to the X axis, and the Z axis is orthogonal to the X axis and Y axis, that is, perpendicular to the X-Y plane. This relationship is merely an example, and it is only necessary that all of the plurality of acceleration sensors are so set as to have the same standard axis. Specifically, while the direction in parallel to the longitudinal direction of the biological sample measuring sensor is defined as the X axis serving as the standard axis in  FIG. 12A , the direction in parallel to the longitudinal direction of the biological sample measuring sensor may be defined as the Y axis serving as the standard axis, or alternatively, the direction in parallel to the longitudinal direction of biological sample measuring sensor may be defined as the Z axis serving as the standard axis. In other words, it is only necessary that the three-dimensional acceleration sensors are so set as to have a common (same) X axis, Y axis, and Z axis. 
         [0077]    The following description explains a measured acceleration GA and a measured acceleration GB respectively measured by three-dimensional acceleration sensor  5   a  and three-dimensional acceleration sensor  5   b  illustrated in  FIG. 12A . The accelerations GA and GB are expressed as follows. Here, the accelerations GA and GB each represent a vector value showing the direction and magnitude as illustrated in  FIG. 12B . In the expression, GAx, GAy, and GAz represent x, y, and z components of GA, respectively. Likewise, GBx, GBy, and GBz represent x, y, and z components of GB, respectively (the same shall apply hereinafter). 
         [0078]    GA=GAx+GAy+GAz (this expresses the vectorial sum of X-, Y-, and Z-axis components) 
         [0079]    GB=GBx+GBy+GBz (this expresses the vectorial sum of X-, Y-, and Z-axis components) 
         [0080]    The measured accelerations GA and GB are defined as follows according to when the measurement is made. 
         [0081]    Accelerations measured at the time of insertion of biological sample measuring sensor  11  in sensor insertion port  1 : GA 1 , GB 1   
         [0082]    Accelerations measured while blood glucose level is being measured: GA 2 , GB 2  (each of the measured accelerations GA 2  and GB 2  is not limited to one, and, normally, measured multiple times) 
         [0083]    Accelerations measured at the time of ejection of biological sample measuring sensor  11  from sensor insertion port  1 : GA 3 , GB 3   
         [0084]    Determination can be made as follows based on measured accelerations GA 2  and GB 2 . When measured accelerations GA 2  and GB 2  cannot be obtained, it is determined that the biological sample measuring apparatus itself is an error (broken). When “measured accelerations GA 2  and GB 2 &gt;threshold level L 3 ”, it is determined that the biological sample cannot be measured, and confirmation whether the measuring apparatus is broken and remeasurement are requested. When “threshold level L 3 &gt;measured accelerations GA 2  and GB 2 &gt;threshold level L 2 ”, it is determined that the measurement may not have appropriately made, and replacement of the biological sample measuring sensor and remeasurement are requested. When “measured accelerations GA 2  and GB 2 ≦threshold level L 2 ”, it is determined that the measurement has been appropriately made. 
         [0085]    Naturally, it is also possible to compare only the measured accelerations GA 2  with threshold level L 2  to determine whether the measurement has been made appropriately. In addition, when acceleration sensors  5   a  and  5   b  have different sensitivities, measured accelerations GA 2  and GB 2  obtained by subjecting data received from acceleration sensors  5   a  and  5   b  to sensitivity conversion are compared with threshold levels L 2  and L 3 , respectively. The sensitivity conversion is carried out by determination section  9  or control section  8  (see  FIG. 10 , for example). 
         [0086]    In addition, determination can also be made as follows based on X-, Y-, and Z-axis components (measured acceleration components) of measured accelerations GA 2  and GB 2 . When “measured acceleration components GA 2   x , GA 2   y , GA 2   z , GB 2   x , GB 2   y  or GB 2   z &gt;threshold level L 3 ”, it is determined that an impact is received during the measurement of blood glucose level, and therefore blood glucose level cannot be measured. When “measured acceleration component GB 2   z  (GB 2   x , or GB 2   y )&gt;threshold level L 2 ”, it is determined that an impact is received during the measurement, and therefore blood glucose level may have not been appropriately measured. When “measured acceleration component GA 2   x , GA 2   y , GA 2   z , GB 2   x , GB 2   y  and GB 2   z ≦threshold level L 2 ”, it is determined that the measurement has been appropriately made. 
         [0087]    The following specifically describes the case where the biological sample measuring sensor is flicked by a finger or the like.  FIG. 12C  illustrates an exemplary output signal waveform Wg in a Z-axial direction, which is one of signals output from three-dimensional acceleration sensor  5   a  when a finger or the like makes contact with biological sample measuring sensor  11  during the measurement of blood glucose level. Here, in consideration of the positional relationship of the sensor insertion section and the contact pin, a case is studied in which a significant movement is caused in a vertical direction relative to the planer face of biological sample measuring sensor  11 , that is, in the Z-axial direction. 
         [0088]    When a finger or the like makes contact with biological sample measuring sensor  11 , or when biological sample measuring sensor  11  is released from a bending state, an output signal Wg in a form of an oscillation waveform in  FIG. 12C  is output from acceleration sensor  5   a . Specifically, the value of the measured acceleration of GAz largely oscillates up and down (that is, in the positive/negative direction) with respect to the center: 0, and attenuates as time t passes. 
         [0089]    The data of the output signal Wg representing the change of the value of the measured acceleration in the Z-axial direction is retrieved at determination section  9  from three-dimensional acceleration sensor  5   a , and stored in memory section  10 . The pieces of measured acceleration data of acceleration sensor  5   a  and the threshold level L 2  are compared, and it is determined at determination section  9  whether the threshold level L 2  is exceeded. To be more specific, initial peak values of the Z-axis output signal Wg (P 1 , P 3 , P 5  and the like as the positive peak values and P 2 , P 4 , P 6  and the like as the negative peak values) are obtained, and the values thus obtained are compared with the threshold level L 2  for determination during the measurement of acceleration sensor  5   a . Then, when the peak value P 1  is greater than the positive threshold level L 2  (+L 2 ), and/or when the peak value P 2  is smaller than the negative threshold level L 2  (−L 2 ), it is determined to be an error. 
         [0090]    In addition, it is seen from the example of  FIG. 12C  that the output signal Wg includes positive peak values P 1  and P 3  which are greater than the threshold level +L 2 , and has a form of an oscillation waveform. Likewise, the output signal Wg includes negative peak values P 2  and P 4  which are lower than the threshold level −L 2 , and has a form of an oscillation waveform. As described, since a plurality of peak values are detected and an oscillation waveform is confirmed, it is recognized that the error has been caused by “a finger or the like making contact with the biological sample measuring sensor”, not by dropping of the measuring apparatus or clashing of the measuring apparatus with external objects. 
         [0091]    On the other hand, in the case of “dropping of the measuring apparatus or clashing of the measuring apparatus with external objects”, the oscillation waveform illustrated in  FIG. 12C  is not obtained, and only one peak value is typically shown. Specifically, not the waveform whose peak value gradually attenuates as time passes as illustrated in  FIG. 12C , but a waveform whose large peak value abruptly attenuates after the peak value is caused at the time of the impact as illustrated in  FIG. 12D  is typically obtained. 
         [0092]      FIG. 12D  illustrates an exemplary output signal Wg of the Z-axis component of three-dimensional acceleration sensor  5   a  in the case of “dropping of the measuring apparatus or clashing of the measuring apparatus with external objects.” In the example of  FIG. 12D , peak P 1  at the time of the impact has a high peak value exceeding not only the threshold level +L 2  but also the positive threshold level L 3  (+L 3 : the threshold level L 3  is “a threshold level at which the measurement itself is determined to be impossible”). Specifically, errors are discriminated from each other by comparison between the threshold level L 3  (+L 3 ) and a peak value P 1  in the measured acceleration data of the Z-axis component of the measured acceleration GA (or GA 2  during the measurement) of capacitance-type three-dimensional acceleration sensor  5   a . In other words, discrimination according to the magnitude of the impact can be made. Likewise, when a value of the peak P 2  which is the maximum value on the negative side is lower than the negative threshold level L 3  (−L 3 ), it is determined that the error has been caused possibly by “dropping of the measuring apparatus or clashing of the measuring apparatus with external objects.” 
         [0093]    While  FIG. 12D  illustrates an exemplary case where both of the peak values of P 1  and P 2  are greater than the threshold level L 3 , this is not limitative. Alternatively, only peak P 1  may be greater than the threshold level L 3 , or only peak P 2  may be greater than the threshold level L 3 . This is because the impact is applied with variety of intensities and directions, and therefore cannot be limited to a single type of impact. Accordingly, it is necessary to compare the threshold levels (+L 3 , −L 3 , and the like) with the peak values on the positive side and negative side. 
         [0094]    In addition, the error of  FIG. 12D  can be discriminated from the error caused by “a finger or the like making contact with biological sample measuring sensor” based on the fact that the oscillation waveform as illustrated in  FIG. 12C  is not obtained in the case of  FIG. 12D . 
         [0095]    As described above, since the output signal Wg from the acceleration sensors is monitored in the present invention, it is possible to discriminate not only the magnitudes of the impact, but also the causes of the impact by checking the waveform of the output signals Wg (by checking whether an oscillation waveform is obtained, for example). Consequently, an instruction, display, and notification of caution and warning can be correctly presented to the user at the time of the biological sample measurement, and thus, the safety and reliability of the measuring apparatus are improved. 
         [0096]    While  FIG. 12C  illustrates an example of a gradually attenuating oscillation waveform, the form of the waveform is not limited to this. Also in the case of the oscillation waveform illustrated in  FIG. 12C , factors such as the peak values, the frequency or cycle of the oscillation, and the attenuation time may vary, and therefore various waveforms may be obtained. Further, not the oscillation waveform, but a momentary waveform may be observed in the case where the measuring apparatus is dropped and the like. As described, the impact is applied to the measuring apparatus from the outside in various manners, and therefore various waveform patterns are conceivable. 
         [0097]    When an impact has been applied in a direction substantially parallel to the X, Y, or Z axial direction, the measured acceleration component can be compared with the threshold level L 2  or L 3 . Meanwhile, when an impact is applied in a direction not parallel to the X, Y, or Z axial direction, there is a difference between components along respective axes (GB 2   x , GB 2   y , GB 2   z , and the like) and synthesized vector values (GA 2 , GB 2 , and the like, see  FIG. 12B ). Therefore, the determination can be made more accurately not only by comparing the components of the measured acceleration (GB 2   x , GB 2   y , GB 2   z , and the like) with the threshold levels L 1  to L 3 , but also by comparing the synthesized measured accelerations GA 2  and GB 2  with the threshold levels L 1  to L 3 . 
       Embodiment 6 
       [0098]      FIG. 13  illustrates an exemplary waveform pattern of an applied voltage for use in the blood glucose level measurement. Here, measurement timings of the acceleration sensor are described.  FIG. 13  illustrates a waveform of an applied voltage supplied from the measuring apparatus to the detection electrode (electrode for the measurement such as a working electrode and counter electrode) of the biological sample measuring sensor for the purpose of measuring blood glucose levels (glucose level).  FIG. 13  illustrates the case where multi(three)-pulse waveforms (rectangular waves) are applied. 
         [0099]    To be more specific, as pulse PW 1 , a voltage V 1  (e.g., 350 mV or a voltage in the range of 100 to 800 mV can be adopted) is applied for a time t 1  (e.g., for two seconds, or about 0.5 seconds to about 5 seconds) from the start of the measurement. A voltage is not applied for a time t 4  (e.g., for one second or about 0.1 second to about 3 seconds) subsequent to the time t 1 . Next, as a pulse PW 2 , a voltage V 2  (e.g., 250 mV or a voltage in the range of 100 to 800 mV can be adopted) is again applied for a time t 2  (e.g., for two seconds or 0.5 to 5 seconds). A voltage is not applied for a time t 5  (e.g., for 0.1 second, or 0 to 0.1 second) subsequent to the time t 2 . Further, as a pulse PW 3 , a voltage V 3  (e.g., 2.5 V or 1.5 to 3.5 V) is applied for a time t 3  (e.g., for 0.5 seconds or 0.1 to 2 seconds). 
         [0100]    Here, the pulse PW 1  and pulse PW 2  each represent a voltage application for measuring a glucose level, or a voltage application for measuring interfering substances (substances that have influence on the glucose level measurement). Meanwhile, the pulse PW 3  represents a voltage application for measuring an Hct (hematocrit) level. 
         [0101]    In addition,  FIG. 14  illustrates signals output from the detection electrode (a working electrode and a counter electrode, for example) of the biological sample measuring sensor at the time of a blood glucose level measurement, for example, upon application of the pulse voltages illustrated in  FIG. 13 . W 1  represents a signal output from the detection electrode (a working electrode and a counter electrode, for example) upon application of the pulse voltage PW 1  (applied voltage V 1  and applied time t 1 ). W 2  represents an output signal upon application of the pulse voltage PW 2  (applied voltage V 2  and applied time t 2 ). These signals are output signals corresponding to reaction currents generated by redox reactions in the biological sample measuring sensor, that is, glucose levels. Meanwhile, W 3  represents a signal output from an Hct electrode upon application of the pulse voltage PW 3  (applied voltage V 3  and applied time t 3 ). That is, an output signal corresponding to an Hct level. Based on the glucose level, Hct (hematocrit) level, and other data (temperature data, data of interfering materials, and the like), a glucose level (blood glucose level) at a standard temperature is determined. 
         [0102]    When an impact is applied to the measuring apparatus from the outside while the glucose level is being measured in the above-mentioned manner, a reagent dissolved with blood in the reaction deviates from a given position (for example, on the detection electrode), appropriate reaction may not be sufficiently caused, and thus the measured value of the glucose level may not be accurate or the measurement itself may not be made. The above-mentioned case where “impact is applied to the measuring apparatus” includes the case where an impact is applied to the measuring apparatus from the outside, the case where the measuring apparatus is dropped, the case where a finger makes contact with the biological sample measuring sensor, the case where a finger is strongly pressed against the biological sample measuring sensor such that the sensor is deflected when blood is spotted on the biological sample measuring sensor, and the like. 
         [0103]    To solve this problem, the acceleration sensor incorporating the measuring apparatus is used. Specifically, when whether an impact is caused during the measurement is accurately detected, and an impact is detected during the measurement, the measured data is determined to be inaccurate. Therefore, the measured data is not displayed, but an error message is displayed to urge a remeasurement and the like. As a result, only reliable measured values are displayed on the display section, and thus the reliability as a measuring apparatus is improved. 
         [0104]    In addition, when an impact is received during the application of the pulse voltage PW 1 , PW 2  or PW 3 , also the output signal W 1 , W 2  or W 3  in  FIG. 15  typically has an abnormal waveform. Accordingly, the impact can also be detected based on the waveform of the output signal W 1 , W 2  or W 3 . However, the signals are not output during a time period in which a voltage is not applied (time periods t 4  and t 5  in  FIG. 13 ) and immediately before the start of the measurement (before a voltage is applied), and therefore it is difficult to detect an impact based on the output signal waveform. Hence the detection using the acceleration sensor is important. 
         [0105]    While  FIG. 13  and  FIG. 14  illustrate the case where the applied voltage has a multiple waveform including three waveforms of PW 1 , PW 2 , and PW 3 , similar effects can be obtained with a multiple waveform including two waveforms (when the voltage application for the Hct value measurement is not carried out), and with a multiple waveform including four or more waveforms (three or more voltage applications for the glucose measurement). As described above, in the present invention, an impact caused during the blood glucose level measurement can be surely detected regardless of the timing. Consequently, although an accident leading to hypoglycemia which is a very dangerous condition has been caused in the past when the measured value is excessively small due to the impact applied from the outside and insulin is administered more than necessary based on the excessively small measured value, such an accident can be precluded by displaying only highly-reliable measured values on the display section. Thus, the reliability and safety of the measuring apparatus are further ensured. 
       Embodiment 7 
       [0106]      FIG. 15  illustrates a modification of the biological sample measuring apparatus for blood glucose level measurement and the like in  FIG. 9  and  FIG. 10 , and illustrates a biological sample measuring apparatus including measuring apparatus main body  40  having display section  47 , and cover  41  for covering part of measuring apparatus main body  40 . Cover  41  is provided with sensor insertion section  1  for insertion of biological sample measuring sensor  11 , and further, acceleration sensor  5   a  on a rear surface thereof. 
         [0107]    Acceleration sensor  5   a  provided on the rear surface of cover  41  is electrically connected to electric circuits of the control section and the like incorporated in main body  40  via wiring  42 , connecting section  43 , connecting section  44  of main body when cover  41  is installed to measuring apparatus main body  40 . Thus, power is supplied to acceleration sensor  5   a  from apparatus main body  40  by way of connecting section  44  and/or the like when cover  41  is installed to apparatus main body  40 , and in addition, a signal from acceleration sensor  5   a  can be sent to the apparatus main body  40 . 
         [0108]    In addition, biological sample measuring sensor  11  makes contact with connection electrode section  11   b  (which is connected to detection electrodes for measurement such as a working electrode and a counter electrode) of biological sample measuring sensor  11 , and a plurality of contact pins  45  disposed at sensor contact section  46  of measuring apparatus main body  40 , thereby establishing an electrical connection to the electric circuits of the measurement section and the like in measuring apparatus main body  40 . 
         [0109]    When acceleration sensor  5   a  is provided to replaceable cover  41  in the biological sample measuring apparatus illustrated in  FIG. 15 , acceleration sensors having different sensitivities can be used by replacing cover  41 . As an additional sensor, acceleration sensor  5   b  (not illustrated) may be provided on substrate  4  of measuring apparatus main body  40 . By making the sensitivities of the two acceleration sensors  5   a  and  5   b  different from each other, impacts of different magnitudes can be detected. Consequently, the impact caused when biological sample measuring sensor  11  is touched is detected with high sensitivity, and thus it is possible to improve the detection performance during the measurement and to achieve more reliable measurement and a more reliable measuring apparatus. 
       Embodiment 8 
       [0110]    When the amount of the biological sample spotted on biological sample measuring sensor  11  is excessively small, the measurement of the amount of the biological component (e.g., blood glucose level measurement and the like) cannot be made appropriately. In that case, the measurement is occasionally made after additionally spotting (also referred to as “additional application”) the biological sample. Therefore, in some cases, it is necessary to wait for a certain time period until an additional spot application is received after the amount of the biological sample spotted thereto is determined to be excessively small.  FIG. 16  illustrates an operational flow in which whether “additional application” as the above-mentioned additional spotting has been carried out is detected by acceleration sensor  5   a  and/or the like. In the operational flow illustrated in  FIG. 16 , the additional application is detected by acceleration sensor  5   a  disposed in sensor insertion section  1  (see  FIG. 11 , for example). In the following, steps S 21  to S 33  are described in detail. 
         [0111]    S 21 : The installment of biological sample measuring sensor  11  is confirmed. Whether biological sample measuring sensor  11  is installed to sensor insertion section  1  (see  FIG. 11 , for example) is confirmed by confirming the conduction/resistance value between terminals of contact section  16   a  on the measuring apparatus (a plurality of contact pins  20 , see  FIG. 9 ,  FIG. 15 , for example) that makes contact with connection electrode section  11   b  (see  FIG. 12 , for example) of biological sample measuring sensor  11 . When the installment of biological sample measuring sensor  11  is confirmed, the process is advanced to step S 22 . 
         [0112]    S 22 : When the installment of biological sample measuring sensor  11  has been confirmed, a main power source of measuring apparatus is turned ON. Thus, display section  3  (see  FIG. 1 , for example) and/or the like is allowed to perform display. It is to be noted that the main power source may be turned ON by pushing a power source button of measuring apparatus. 
         [0113]    S 23 : The model of installed biological sample measuring sensor  11  is determined. The model determination is carried out based on the difference of a pattern and the like provided at connection electrode section  11   b  of biological sample measuring sensor  11 . 
         [0114]    S 24 : When the model thus determined is not a proper model, the process is advanced to step S 25 , whereas when the model thus determined is a proper model, the process is advanced to step S 26 . 
         [0115]    S 25 : A model error message (in  FIG. 16 , error code “E7”) is displayed, and an instruction to replace biological sample measuring sensor  11  with a proper model is issued. Then, the process is returned to S 21 . 
         [0116]    S 26 : A message that urges “spot application of blood” is displayed to urge the user to spot blood on biological sample measuring sensor  11 . 
         [0117]    S 27 : Whether blood has been spotted on spot application section  11   a  of biological sample measuring sensor  11  is determined. To confirm spot application of blood, a plurality of “detection electrodes” are provided along a flow direction of blood, and change in resistance value and the like are detected between the detection electrodes when inflow of blood occurs. For example, at first, spot application is detected at a first detection electrode nearest spot application section  11   a  of biological sample measuring sensor  11 . When spot application of blood has been confirmed, the process is advanced to step S 28 . 
         [0118]    Alternatively the spot application of blood may be indirectly detected by acceleration sensor  5   a  (see  FIG. 11 , for example). Specifically, when a user spots blood exuded from a finger on spot application section  11   a  disposed at an end of biological sample measuring sensor  11 , the finger naturally makes contact with biological sample measuring sensor  11 . The contact thus made can be detected at acceleration sensor  5   a . In that case, it is only necessary to detect the contact between the finger and biological sample measuring sensor  11 . 
         [0119]    The manner of bringing a finger into contact with spot application section  11   a  of biological sample measuring sensor  11  for spot application of blood varies from user to user. Some users strongly press spot application section  11   a  with a finger, while others softly make contact with spot application section  11   a  with a finger. Accordingly, it is preferable that the threshold level L 4  for detecting a contact between the finger and the biological sample measuring sensor be smaller than the threshold level L 2  for determining the impact during the measurement. It suffices that L 4 ≦L 2 , but preferably, L 4 =α*L 2  (α=about 1/1 to about 1/10). It suffices to set the threshold level L 4  at about 0.005 g to about 0.3 g for example. 
         [0120]    S 28 : Whether blood has sufficiently flowed into a capillary of sensor  11   a  (supply path not illustrated) is detected at a second detection electrode (detection electrode disposed at a position farthest from spot application section  11   a ). When inflow of blood is detected, it is determined that a sufficient amount of blood required for measurement has flowed into the capillary (supply path) of biological sample measuring sensor  11 , and the process is advanced to step S 33 . Meanwhile, when inflow of blood is determined to be insufficient, the process is advanced to step S 29 . It is preferable that the second detection electrode be disposed at a position farthest from spot application section  11   a , but it suffices that the second detection electrode is disposed on the depth side of the capillary relative to the detection electrodes such as a working electrode and counter electrode for detecting an oxidation-reduction reaction current (distal side from spot application section  11   a ). 
         [0121]    S 29 : In a sequence of additional spotting (additional application) of biological sample, a time period (suspension time period for additional application) during which the operation is suspended until “additional application (additional spotting)” is received is set. Preferably, the additional application suspension time is, for example, about 10 seconds to about 120 seconds, preferably, 15 to 60 seconds. 
         [0122]    S 30 : The suspension time period for additional application is monitored, and the lapse of the suspension time period, if any, is determined to be an error as “spotting defect”/“insufficient spotting amount”. Then an error message is displayed on display section  3  and a warning sound is output by a sounder to urge replacement of biological sample measuring sensor  11  and remeasurement. 
         [0123]    S 31 : Whether the user&#39;s finger has made contact with spot application section  11   a  is detected by acceleration sensor  5   a  (see  FIG. 11 , for example) to determine whether additional spotting has been carried out on biological sample measuring sensor  11 . Basically, step  31  is similar to step S 27 , and the threshold level L 4  is set as in the case of step S 27 . When the additional spotting is detected, the process is advanced to step S 32 . When additional spotting cannot be detected, the process is returned to step S 30 . 
         [0124]    S 32 : Similarly to the above-mentioned step S 28 , inflow of blood is detected according to change in resistance value and the like between the second detection electrode disposed at a position farthest (most distant in the depth direction) from spot application section  11   a  and a predetermined electrode. When blood is detected, it is determined that blood sufficient for measurement has flowed into the capillary (supply path) of biological sample measuring sensor  11 , and the process is advanced to step S 33 . When it is determined that the blood is insufficient, the process is returned to step S 30 . 
         [0125]    S 33 : When the spot application amount (the amount of a sample (specimen) such as blood) is sufficient and it is determined that the measurement can be made, a message “spot application is completed” is displayed, and then blood glucose level is measured. 
       INDUSTRIAL APPLICABILITY 
       [0126]    As described above, the present invention includes a main body case including a sensor insertion section; a measurement section connected to the sensor insertion section; a control section connected to the measurement section; and a display section connected to the control section, wherein an acceleration sensor that detects an impact applied to the sensor insertion section is provided. Thus, the reliability of measured value and measurement accuracy can be improved. 
         [0127]    Specifically, in the present invention, the acceleration sensor detects an impact applied to the sensor insertion section via a biological sample measuring sensor, for example. When the impact detected by the acceleration sensor is greater than a predetermined value, it is possible to determine the measurement result measured by the measurement section to be inadequate, and to display, on the display section, the fact that the measurement result is inadequate without displaying the measured value. Therefore, an inadequate measurement result with unreliability is prevented from being displayed, and improvement in measurement accuracy is achieved. Consequently, utilization of a biological sample measuring apparatus of the present invention as a biological sample measuring apparatus for measuring blood glucose levels, lactate level, and the like is anticipated. 
       REFERENCE SIGNS LIST 
       [0000]    
       
           1  Sensor insertion section 
           2  Main body case 
           3  Display section 
           4  Substrate 
           5 ,  5   a ,  5   b  Acceleration sensor 
           6  Control device 
           7  Measurement section 
           8  Control section 
           9  Determination section 
           10  Memory section 
           11  Biological sample measuring sensor 
           11   a  Spot application section 
           12  Insertion detection section 
           13  Buzzer 
           14 ,  15  Operation button 
           16  Install section 
           16   a  Connector section 
           20  Contact pin 
           21  Contact section 
           22  Protrusion 
           29  Wiring 
           40  Measuring apparatus main body 
           41  Cover 
           42  Wiring 
           43  Connecting section 
           44  Connecting section 
           45  Contact pin 
           46  Sensor contact section 
           47  Display section