Abstract:
A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.

Description:
BACKGROUND 
       [0001]    1. Field of Invention 
         [0002]    The present invention relates generally to medical devices and, more particularly, to devices used for determining physiological parameters of a patient. 
         [0003]    2. Description of the Related Art 
         [0004]    This section is intended to introduce the reader to various aspects of art that may be related to various aspects of the present invention, which are described and/or claimed below. This discussion is believed to be helpful in providing the reader with background information to facilitate a better understanding of the various aspects of the present invention. Accordingly, it should be understood that these statements are to be read in this light, and not as admissions of prior art. 
         [0005]    In the field of medicine, caregivers, such as doctors and nurses, desire to discover ailments in a timely manner in order to better care for patients. The unfortunate passage of time prior to discovering an ailment may limit treatment options and, in some instances, may lead to irreversible damage. If an ailment is discovered early enough, however, a variety of remedial options and corrective actions may be initiated in order to treat the condition and prevent further damage to the health of the patient. Accordingly, healthcare professionals are continuously pursuing methods to expedite the diagnosis of a problem or to anticipate a potential problem in order to better serve their patients. 
         [0006]    Skin wounds stem from a number of different causes and understanding the etiology of the wounds allows for appropriate treatment. Some major categories for skin wounds include pressure ulcers (a/k/a bed sores), skin tears, venous ulcers, arterial ulcers, diabetic skin ulcers, and melanoma. The localization of fluid in the dermis is a precursor in a variety of skin wounds but is often not detected until signs of edema and the breakdown of skin become visually apparent. At this point, the number of treatment options is limited and initiating treatment generally results in a very slow healing process or a worsening of the condition. Concomitantly, changes in protein content in some pathologies result in increased risk of the development and/or morbidity associated with skin wounds. Epidermal hyper-proliferation and/or dermal fibrosis result in changes in the distensibility of the collagen networks and, therefore, the water holding capability of the tissue. Early detection of skin edema could significantly improve diagnosis and treatment of these morbidities. 
         [0007]    The various types of skin wounds can be differentiated by knowing the patient history, as well as if and where the fluid is localizing. As an example, pressure sores are often marked by the presence of hemosiderin deposits (a protein resulting from the breakdown of red blood cells) and fluid accumulation in all layers of the dermis. Venous ulcers have a dramatic increase in fluid primarily in the papillary dermis. Alternatively, skin tears exhibit little change and a net loss of water from the dermis 
         [0008]    Commonly, pressure sores occur on individuals where pressure is applied due to patient lying down or sitting in a chair and occur most frequently on the back of the head, the shoulders and shoulder blades, the elbows, the tailbone and base of the buttocks, the hips, the knees and sides of legs, and the heel and bony parts of the feet. In severe cases, pressure sores may necessitate amputation. Bed sores, for example, are a type of pressure sore seen in patients who have remained in bed for prolonged periods. Several discrete steps have been observed to be associated with the development of bed sores. Fluid is initially forced away from pressure points and then returns to create an inflammatory response causing redness and pitting. The redness leaves and eventually the skin hardens. Finally, the skin splits and a bed sore is formed. Other types of skin wounds, such as diabetic ulcers and cancer, develop differently and may not exhibit the same characteristics. 
         [0009]    Currently, physical examination by the clinician and patient history are primarily used in determining skin wound etiology. To date, however, little work has been done to determine the spectral changes in the skin during skin wound development. In some cases, ultrasound technology is used to determine intradermal echogenicity. However, use of ultrasound technology may have several disadvantages. For example, ultrasound technology may not be sensitive to minor or minute changes, as the ultrasound technology only indicates when macroscopic changes have occurred. Additionally, ultrasound technology is not specific, meaning it may have inter-patient variability. 
         [0010]    In addition to the localization of fluid in the dermis, excessive accumulations of fluid can occur in a variety of body compartments. Such accumulations may occur due to injury, inflammation, or excessive fluid resuscitation. In general, these accumulations cause an increase in pressure within the compartment and cut off blood flow, potentially causing organ failure and necrosis. Treatment typically requires incisions to relieve pressure. For example, abdominal compartment syndrome causes organ ischemia and failure, and it is commonly treated by opening the abdomen. Additionally, extremity compartment syndrome may cause ischemia and gangrene, and it is commonly treated by fasciotomies. 
         [0011]    The occurrence of extremity compartment syndrome depends primarily on the precipitating injuries. For major fractures with associated vascular injury, prevalence has been estimated at 15-30%. Chronic and acute exertional compartment syndromes are also known. Extremity compartment syndrome is diagnosed by pain, paresthesia, pressure, pallor, paralysis, and pulselessness, in descending order of frequency and includes conditions such as shin splints and gout. 
         [0012]    The prevalence of intra-abdominal hypertension (tissue pressure greater than 12 mm of Hg) has been estimated at 2-33% in the critically ill, with about half developing abdominal compartment syndrome (greater than 20 mm of Hg). Diagnosis and treatment of abdominal compartment syndrome currently begins at an intra-abdominal pressure greater than 12 mm Hg (normal is less than 5 mm Hg). Intra-compartmental pressures less than 20 mm Hg are generally considered acceptable only if carefully monitored. 
       SUMMARY 
       [0013]    Certain aspects commensurate in scope with the originally claimed invention are set forth below. It should be understood that these aspects are presented merely to provide the reader with a brief summary of certain forms the invention might take and, these aspects are not intended to limit the scope of the invention. Indeed, the invention may encompass a variety of aspects that may not be set forth below. 
         [0014]    In accordance with one aspect of the present invention there is provided a method for determining fluid parameters of living tissue. The method includes transmitting electromagnetic radiation at a tissue site using an emitter and detecting the electromagnetic radiation reflected and scattered by the tissue using a photodetector, the photodetector generating a signal corresponding to the detected electromagnetic radiation. The generated signals are processed to calculate fluid parameters of the tissue site. The method also includes correlating the calculated fluid parameters to a condition status by comparing the calculated fluid parameters with baseline fluid parameters and correlating the comparison to the condition status. The condition status is then indicated on a display. 
         [0015]    In accordance with another aspect of the present invention there is provided a system for detecting skin wounds and compartment syndromes. The system includes a sensor comprising at least one emitter and at least one detector and a spectrophotometric unit communicatively coupled to the sensor. The spectrophotometric unit being configured to calculate fluid parameters and correlate the fluid parameters to a condition status, wherein the spectrophotometric unit compares the calculated fluid parameters to baseline fluid parameters and determines the condition status from the comparison. The system also includes a display coupled to the spectrophotometric unit configured to display the condition status. 
         [0016]    In accordance with yet another aspect of the present invention there is provided a method for diagnosing skin wounds and compartment syndromes. The method including selecting a baseline fluid parameter of a tissue site in a spectrophotometric device and using the spectrophotometric device to calculate data indicative of a condition status. Using the spectrophotometric device comprises placing a sensor on an area of a patient&#39;s skin over the tissue site for which baseline fluid parameters were entered and taking measurements using the sensor, the spectrophotometeric device being configured to display the measurements. The method also includes making a diagnosis based on consideration of the patient&#39;s medical history and the data calculated by the spectrophotometric monitor. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0017]    Certain exemplary embodiments are described in the following detailed description and in reference to the drawings, in which: 
           [0018]      FIG. 1  illustrates a block diagram of a diagnostic system in accordance with an exemplary embodiment of the present invention; 
           [0019]      FIG. 2  illustrates a cross-sectional view of a sensor for use with the system of  FIG. 1  in accordance with an exemplary embodiment of the present invention; 
           [0020]      FIG. 3  illustrates an alternative view of the sensor in the plane indicated by lines  3 - 3  of  FIG. 2  in accordance with an exemplary embodiment of the present invention; 
           [0021]      FIG. 4  illustrates a sensor having multiple detectors in accordance with an alternative embodiment of the present invention; 
           [0022]      FIG. 5  illustrates a sensor having a roller-ball in accordance with another alternative exemplary embodiment of the present invention; 
           [0023]      FIG. 6  illustrates a sensor having a thermometer sensor in accordance with yet another alternative embodiment of the present invention; 
           [0024]      FIG. 7  illustrates a sensor having a roller-ball, a thermometer and multiple detectors in accordance with still another alternative embodiment of the present invention; 
           [0025]      FIG. 8  illustrates a technique for detecting skin wounds and compartment syndromes in accordance with an exemplary embodiment of the present invention; and 
           [0026]      FIG. 9  illustrates a technique for correlating fluid parameters to a possible condition in accordance with an exemplary embodiment of the present invention. 
       
    
    
     DETAILED DESCRIPTION 
       [0027]    One or more specific embodiments of the present invention will be described below. In an effort to provide a concise description of these embodiments, not all features of an actual implementation are described in the specification. It should be appreciated that in the development of any such actual implementation, as in any engineering or design project, numerous implementation-specific decisions must be made to achieve the developers&#39; specific goals, such as compliance with system-related and business-related constraints, which may vary from one implementation to another. Moreover, it should be appreciated that such a development effort might be complex and time consuming, but would nevertheless be a routine undertaking of design, fabrication, and manufacture for those of ordinary skill having the benefit of this disclosure. 
         [0028]    The use of spectrophotometric means for measuring and calculating fluid metrics are described in U.S. Pat. No. 6,591,122. Additionally, U.S. Pub. 2003-0220548, 2004-0230106, 2006-0084864; U.S. Ser. Nos. 11/283,506 and 11/282,947; and the patent application titled “Tissue Hydration Estimation by Spectral Absorption Bandwidth Measurement” U.S. Ser. No. ______, discuss methods for measuring and calculating fluid metrics. The techniques, methods and apparatuses disclosed in the aforementioned patents, publications and applications may be implemented in particular embodiments of the present invention. As such, each of the aforementioned patents, publications and applications are incorporated herein by reference. 
         [0029]    The fluid metrics computed by the above mentioned references typically have correlated a local measurement to a whole body water value. Spectrophotometric means, however, may also be used in calculating a local fluid measurement. Specifically, similar measurements, such as the ratio of water-to-water and other constituents, may be taken but the data may be interpreted to indicate a local fluid metric rather than a whole body fluid metric. The local fluid measurement may then be used in the diagnosis of various skin disorders as well as compartment syndromes, as will be discussed in detail below. 
         [0030]    Human organs have a normal water content that may be used as a baseline reference for determining if any irregularities are present The percent water component of most organs is 50-80%, whereas the percent water component of skin is approximately 70% and the water percentage of the lungs is approximately 95%. A local fluid measurement may be compared against the reference level, and deviation from the reference level may be indicative of various conditions that may be present in a particular organ or compartment. In the case of compartmental syndromes, for example, an increase of fluid above the reference level in a particular compartment may be detected by a spectrophotometric monitor. This reference level may be a predetermined patient-independent level or an earlier measurement on the same patient and site, or concurrent measurement from one or more different sites on the same patient. 
         [0031]    The use of spectrophotometric devices provides the advantage of early detection, allowing for proper treatment and preventative measures to be taken to avoid further damage. Additionally, the spectrophotometric devices are non-invasive.  FIG. 1  illustrates a block diagram implementing a spectrophotometric device in a diagnostic system  10  in accordance with an exemplary embodiment of the present invention. The diagnostic system  10  includes a sensor unit  12  having an emitter  14  configured to transmit electromagnetic radiation, such as light, into the tissue of a patient  16 . The electromagnetic radiation is scattered and absorbed by the various constituents of the patient&#39;s tissues, such as water and protein. A photoelectric detector  18  in the sensor  12  is configured to detect the scattered and reflected light and to generate a corresponding electrical signal. The sensor  12  directs the detected signal from the detector  18  into a spectrophotmetric device  20 . 
         [0032]    The spectrophotometric device  20  has a microprocessor  22  which calculates fluid parameters using algorithms programmed into the spectrophotometric device  20 . The microprocessor  22  is connected to other component parts of the spectrophotometric device  20 , such as a ROM  26 , a RAM  28 , and control inputs  30 . The ROM  26  holds the algorithms used to compute the fluid levels or metrics. The RAM  28  stores the values detected by the detector  18  for use in the algorithms. 
         [0033]    Methods and algorithms for determining fluid parameters are disclosed in U.S. Pub. No. 2004-0230106, which has been incorporated herein by reference. Some fluid parameters that may be calculated include water-to-water and protein, water-to-protein, and water-to-fat. For example, in an exemplary embodiment the water fraction, f w , may be estimated based on the measurement of reflectances, R(λ), at three wavelengths (λ 1 =1190 nm, λ 2 =1170 nm and λ 3 =1274 nm) and the empirically chosen calibration constants c 0 , c 1  and c 2  according to the equation: 
         [0000]        f   w   =c   2  log [ R (λ 1 )/ R (λ 2 )]+ c   1  log [ R (λ 2 )/ R (λ 3 )]+ c   0 .   (1) 
         [0034]    In an alternative exemplary embodiment, the water fraction, f w , may be estimated based on the measurement of reflectances, R(λ), at three wavelengths (λ 1 =1710 nm, λ 2 =1730 nm and λ 3 =1740 nm) and the empirically chosen calibration constants c 0  and c 1  according to the equation: 
         [0000]    
       
         
           
             
               
                 
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         [0000]    Total tissue water accuracy better than ±0.5% can be achieved using Equation (2), with reflectances measured at the three closely spaced wavelengths. Additional numerical simulations indicate that accurate measurement of the lean tissue water content, f w   1 , can be accomplished using Equation (2) by combining reflectance measurements at 1125 nm, 1185 nm and 1250 nm. 
         [0035]    In an alternative exemplary embodiment, the water content as a fraction of fat-free or lean tissue content, f w   1 , is measured. As discussed above, fat contains very little water so variations in the fractional fat content of the body lead directly to variations in the fractional water content of the body. When averaged across many patients, systemic variations in water content result from the variation in body fat content. In contrast, when fat is excluded from the calculation, the fractional water content in healthy subjects is consistent. Additionally, variations may be further reduced by eliminating the bone mass from the calculations. Therefore, particular embodiments may implement source detector separation (e.g. 1-5 mm), wavelengths of light, and algorithms that relate to a fat-free, bone-free water content. 
         [0036]    In an alternative embodiment, the lean water fraction, f w   1 , may be determined by a linear combination of two wavelengths in the ranges of 1380-1390 nm and 1660-1680 nm: 
         [0000]        f   w   1   =c   2  log [ R (λ 2 )]+ c   1  log [ R (λ 1 )]+ c   0 .   (3) 
       Those skilled in the art will recognize that additional wavelengths may be incorporated into this or other calibration models in order to improve calibration accuracy. 
       [0037]    In yet another embodiment, tissue water fraction, f w , is estimated according to the following equation, based on the measurement of reflectances, R(λ), at a plurality of wavelengths: 
         [0000]    
       
         
           
             
               
                 
                   
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         [0000]    where p n  and q m  are calibration coefficients. Equation (4) provides cancellation of scattering variances, especially when the N+1 wavelengths are chosen from within the same band (i.e. 950-1400 nm, 1500-1800 nm, or 2000-2300 nm). 
         [0038]    Referring again to  FIG. 1 , control inputs  30  allow a user to interface with the spectrophotometric monitor  20 . For example, if a particular spectrophotometric device  20  is configured to detect compartmental disorders as well as skin disorders, a user may input or select parameters, such as baseline fluid levels for the skin or a particular compartment of the body that is to be measured. Specifically, baseline parameters associated with various compartments or regions of the body or skin may be stored in the spectrophotometric monitor  20  and selected by a user as a reference level for determining the presence of particular condition. Additionally, patient data may be entered, such as weight, age and medical history data, including, for example, whether a patient suffers from emphysema, psoriasis, etc. This information may be used to validate the baseline measurements or to assist in the understanding of anomalous readings. For example, the skin condition psoriasis would alter the baseline reading of skin water and, therefore, would affect any determination of possible bed sores or other skin wounds. 
         [0039]    Detected signals are passed from the sensor  12  to the spectrophotometric device  20  for processing. In the spectrophotometric device  20 , the signals are amplified and filtered by amplifier  32  and filter  34 , respectively, before being converted to digital signals by an analog-to-digital converter  36 . The signals may then be used to determine the fluid parameters and/or stored in RAM  28 . 
         [0040]    A light drive unit  38  in the spectrophotometric device  20  controls the timing of the emitters  14 . While the emitters are manufactured to operate at one or more certain wavelengths, variances in the wavelengths actually emitted may occur which may result in inaccurate readings. To help avoid inaccurate readings, an encoder  40  and decoder  42  may be used to calibrate the spectrophotometric monitor  20  to the actual wavelengths being used. The encoder  40  may be a resistor, for example, whose value corresponds to coefficients stored in the spectrophotometric device  20 . The coefficients may then be used in the algorithms. Alternatively, the encoder  40  may also be a memory device, such as an EPROM, that stores information, such as the coefficients themselves. Once the coefficients are determined by the spectrophotometric device  20 , they are inserted into the algorithms in order to calibrate the diagnostic system  10 . 
         [0041]    The spectrophotometric device  20  may be configured to display the calculated parameters on display  44 . The display  44  may simply show the calculated fluid measurements for a particular region of tissue where the sensor has taken measurements. The fluid measurements may be represented as a ratio or a percentage of the water or other fluid present in the measured region. As the ratio or percentage may not have any particular significance to a caregiver or clinician, the spectrophotometric monitor may be programmed to correlate the ratio or percentage to a number indicative of a risk level or of a potential stage of development of a particular condition. For example, if a normal fluid ratio is measured, a “1” may be outputted on the display  44 . Alternatively, if an abnormal, but not severely abnormal fluid ratio is measured, a “2” may be displayed. If a severely abnormal measurement is taken, a “3” may be displayed. A color display may also be programmed to correlate the fluid ratios with a particular color. For example, a green, yellow or red light may be shown on the display corresponding to normal, abnormal, and severely abnormal readings, respectively. The color may be used independently or in combination with the number indicator scheme. Regardless of the manner of presentation, the objective is to present the fluid metric information to a clinician in a manner that may be quickly and easily understood. 
         [0042]    In a more complex system, the display  44  may show a graphical image illustrating the fluid measurements or fluid ratios across an area, such as a pressure point and the peripheral area about the pressure point, for example. Regions may be shaded or color coded to indicate relative fluid levels or fluid ratios. For example, normal fluid levels or fluid ratios may be indicated by presenting the region with a green hue on the display  44 . Alternatively, regions that may deviate from a normal fluid level or fluid ratio may be indicated by coloring the region a reddish hue, for example. As the fluid level or fluid ratio may change across an area being measured, the differences in the fluid ratio may be shown by the shading or coloring technique. Indeed, a single graphical image may demonstrate a wide range of shades or hues corresponding to the fluid ratio of a particular region. Such an output display would be advantageous in determining exactly what the problem and/or what the etiology might be. 
         [0043]    Additionally, the graphics may aid in determining the exact location of problem areas, and the severity of the problem. 
         [0044]    Turning to  FIGS. 2 and 3 , a sensor  50  is illustrated in accordance with an exemplary embodiment of the present invention. Specifically,  FIG. 2  illustrates a cross-sectional view of the sensor  50 . The sensor  50  may be a handheld sensor that a caregiver can move around on a patient. As can be seen in  FIG. 2 , the sensor  50  may have a housing  52  having a contoured upper surface to allow a user to easily hold onto the sensor  50 . For example, the housing  52  may be similar in size and shape to a computer mouse. The sensor  50  may be communicatively coupled to the spectrophotometric device  20  via a cable  54 . Alternative embodiments may employ wireless communication technology to transmit information back to spectrophotometric monitor  20 , thus eliminating the cable  54 . 
         [0045]    An alternative view of the sensor  50 , in the plane indicated by the lines  3 - 3  of  FIG. 2 , is illustrated in  FIG. 3 . Specifically,  FIG. 3  shows a substantially flat surface of the sensor housing  52 . The emitter  24  and detector  26  are located on this surface to allow them to efficiently couple to the patient&#39;s skin during use. An optical coupling gel, transparent talc, or other medium may be used to aid in achieving a proper optical coupling between the emitter and detector and the patient&#39;s skin. 
         [0046]    The spacing between the emitter  24  and detector  26  may be determined based upon the region of skin or compartment of the body that is to be tested. Generally, for relatively shallow probing, the emitter and detector may be relatively close to one another, while for deeper probing the emitter  24  and detector  26  will be further separated. For example, when diagnosing skin wounds, the emitter  24  and detector  26  may be one to five mm apart, because the electromagnetic radiation need only penetrate into layers of skin. However, for detecting compartment syndromes, the emitter  24  and detector  26  may be placed further apart, such as five to 15 mm apart, for example, to allow the electromagnetic radiation to penetrate into deeper tissue before being reflected or scattered to the detector  26 . Those skilled in the art will recognize that somewhat shorter and less strongly absorbed wavelengths may be preferred in conjunction with these longer spacings. 
         [0047]    Turning to  FIG. 4 , a sensor  70  having multiple detectors in accordance with an alternative embodiment of the present invention is illustrated. The sensor  70  is capable of sensing various depths of tissue because of the multiple detectors  26   a - d.  Any number of detectors  26   a - d  may be used, and the more detectors that are used, the higher the resolution. In this example, the sensor  70  has four detectors  26   a - d  arranged linearly with increasing distance from the emitter  24 . The detector  26   a,  in closest proximity to the emitter  24 , is used for sensing in shallow tissue, as the light transmitted from the emitter  24  does not penetrate far into the tissue before arriving back at the detector  26   a.  Alternatively, the detector  26   d,  furthest away from the emitter  24 , may be used for sensing deeper tissue because the signals from emitter  24  penetrate deeper into the tissue before arriving at detector  26   d  than those that arrive at detector  26   a.  Accordingly, this arrangement allows for the spectrophotometric device  20  to detect at multiple depths of tissue. Those skilled in the art of mechanical design will recognize that similar results may be achieved with a sensor having a single emitter and detector location with adjustable spacing between them, or a sensor having multiple emitters or emitter locations and a single detector or detector location. 
         [0048]    In order to create a graphical representation of the area tested, a sensor may have a means for indicating a relative position.  FIG. 5  illustrates a sensor  80  having a roller-ball  82  in accordance with an exemplary embodiment of the present invention. The roller-ball  82  tracks the movement of the sensor  80  as it is moved across a potential problem area of a patient. The roller-ball  82  correlates the movement of the sensor to a specific location relative to a starting point. The starting point may be determined by actuation of a button on the sensor or monitor or through voice command, for example, when the sensor  80  is initially placed in contact with the patient&#39;s skin. Alternatively, the start position may be determined by a using a relative position indicator on a bed or operating table. Measurements are taken as the sensor  80  is moved across a patient&#39;s skin. The measurements are then pieced together by correlating the measurements to the specific location relative to the starting point as determined by the roller-ball  82 . A graphical representation of the area over which the sensor  80  passes can then be generated. Thus, a caregiver or patient may receive information in a graphical form. The graphical representation may be useful to a caregiver for many reasons. Particularly, the graphics may be useful in determining the exact parameters of the potential skin wound or compartment syndrome, and also in illustrating and explaining the condition to a patient. It should be understood that the roller-ball  82  is given as an example of how to correlate the detected light to a particular location. Indeed, there may be many other ways to accomplish the same or similar functionality. For example, an optical device may be used to in a similar manner to indicate relative position. 
         [0049]    Additional features may be added to the above described sensor  80  in order to provide additional capability and to enhance performance. For example,  FIG. 6  illustrates a sensor  90  having a roller-ball  82  and a temperature sensor  92  in accordance with an exemplary embodiment of the present invention. It may be desirable to measure the temperature of the patient&#39;s tissue because the radiation spectrum from the emitter  26  may change in accordance with the temperature. Specifically, as temperature increases, the water spectrum is blue-shifted. The temperature may be taken into account when calculating the various parameters by modifying coefficients used in the algorithms to account for any spectrum shifting. Additionally, the temperature measurement may help in distinguishing types of skin wounds. For example, temperature may help in distinguishing between an elevated water level due to an acute injury, which exhibits local temperature increase, and an elevated water level due to a chronic injury, which should not show an increase in temperature. Accordingly, the sensor  90  implementing the temperature sensor  92  may be more accurate and provide increased functionality than a sensor without a temperature sensor. 
         [0050]    Another embodiment combines all of the above described features into a single sensor.  FIG. 7  illustrates a sensor  94  that has multiple detectors  26   a - d,  a roller-ball  82 , and a temperature sensor  92 . The sensor  94  provides all of the advantages described earlier with respect to the embodiments illustrating the features separately. Alternative arrangements of the various features can also be envisioned, and the scope of this disclosure should not be limited to the exemplary embodiments described herein. 
         [0051]    Turning to  FIG. 8 , a technique of detecting skin wounds and compartment syndromes in accordance with embodiments of the present invention is represented by a block diagram and generally designated by the reference numeral  100 . Initially, data is input into a spectrophotometric device, as indicated at block  102 . For example, information such as baseline fluid levels may be input, as they vary according to the particular organ or compartment of the body that is to be measured. Additionally, information such as the part of the body where measurements are to be taken may be input, as different compartments may require different sets of coefficients. For example, if the patient has been involved in an accident and the patient may be suffering from abdominal compartment syndrome, a clinician could enter data indicating that the abdominal compartment will be measured and the baseline fluid levels associated with that compartment will be used for the calculations. Alternatively, if the patient has been confined to a bed or chair and the patient may be likely to develop bed sores, a user could select baseline parameters associated with those particular pressure points, including historical parameters from the same patient, so that an appropriate correlation may be made. 
         [0052]    After the baseline parameters have been selected or the data has been entered into the spectrophotometric device  20 , readings may be taken of areas where the suspected condition may be developing, as indicated at block  104 . The readings are made by placing the sensor on locations around a probable problem spot or by moving the sensor over an area of skin while taking measurements. For example, in the case of abdominal compartment syndrome, multiple points on the abdomen may be tested with the monitor. Alternatively, if the monitor is equipped to do so, an area may be continuously probed while moving the monitor across the patient&#39;s abdomen. 
         [0053]    Once obtained, the readings are used to calculate fluid parameters using algorithms programmed into the spectrophotometric device  20 , as indicated at block  106 . One fluid parameter that may be determined, for example, is the water percentage of the measured tissue. The calculated fluid parameter may be correlated to a possible condition status, as indicated at block  108 . As shown in  FIG. 9 , the correlation may include several steps, which will be discussed in greater detail below. Essentially, the correlation may include a comparison with baseline parameters to determine the presence of a condition. 
         [0054]    A condition indicator may be displayed representing the fluid measurements or the amount of deviation from baseline values, as indicated at block  110 . The condition indicator may be a decimal number or a whole number indicating the percentage of water in the tissue, for example. In an alternative embodiment, a number correlating the amount of deviation from baseline values may be displayed. In yet another embodiment, a graphical representation of the area over which a sensor has passed is displayed. The graphical representation may be coded to indicate the water percentage or amount of deviation from the baseline parameters of a particular area. Specifically, the graphical representation may be color coded, as discussed above. 
         [0055]    The correlation of the fluid parameters to a condition status of block  108  may include several discrete steps, as set forth in the block diagram of  FIG. 9 . For example, the measured parameters may be compared to baseline parameters, as indicated at block  112 . The baseline parameters may be entered or stored in the monitor and used to determine whether or not measured parameters indicate a deviation from a normal state. A categorization may be performed based on the comparison of the measured parameters with the baseline parameters as indicated at block  114 . For example, if the measured parameters are within an acceptable range of the baseline parameters, the patient&#39;s condition may be categorized as normal. As the measured parameters move further away from the baseline parameters, however, the patient&#39;s condition may be categorized as abnormal or severely abnormal, for example. The abnormal state may indicate a particular likelihood that a condition is developing, while a severely abnormal state may indicate that a particular condition is present. 
         [0056]    After the measured parameters have been compared to the baseline parameters and the status of the condition has been determined, a graphic may be generated to represent the status, as indicated at block  116 . As discussed above, the graphic may simply consist of a number indicative of the presence and severity of a potential condition. Alternatively, a particular monitor may be configured to display a graphical representation of an area over which a sensor has taken measurements. The graphical representation may be coded, such as with color, to indicate the status in a particular area. 
         [0057]    The data or images generated and displayed according to the technique  100  may be interpreted by a clinician. Specifically, the clinician may interpret the displayed results in light of the patient&#39;s medical history to make an informed diagnosis. The technique  100  allows for non-invasive diagnosis of skin wounds and compartment syndromes at early stages, thus allowing the opportunity to provide proper care and to take measures to prevent the occurrence of further damage. 
         [0058]    While the invention may be susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and have been described in detail herein. However, it should be understood that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the following appended claims.