Abstract:
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):                            
     that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. 
     This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation-in-part application of U.S. Ser. No. 09/692,023, Filed Oct. 19, 2000, entitled “ACYLSEMICARBAZIDES AND THEIR USES”, now U.S. Pat. No. 6,291,504, which is a non-provisional filing of provisional application 60/160,713, filed Oct. 20, 1999, entitled “ACYLSEMICARBAZIDES AS CYCLIN DEPENDENT KINASE INHIBITORS USEFUL AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS” which applications are herein incorporated by reference in their entirity as though set forth in full. 
    
    
     FIELD OF THE INVENTION 
     This invention relates generally to novel 5-substituted-indeno[1,2-c]pyrazol-4-ones which are useful as cyclin dependent kinase (cdk) inhibitors, pharmaceutical compositions comprising the same, methods for using the same for treating proliferative diseases, and intermediates and processes for making the same. 
     BACKGROUND OF THE INVENTION 
     One of the most important and fundamental processes in biology is the division of cells mediated by the cell cycle. This process ensures the controlled production of subsequent generations of cells with defined biological function. It is a highly regulated phenomenon and responds to a diverse set of cellular signals both within the cell and from external sources. A complex network of tumor promoting and suppressing gene products are key components of this cellular signaling process. Over expression of the tumor promoting components or the subsequent loss of the tumor suppressing products will lead to unregulated cellular proliferation and the generation of tumors (Pardee, Science 246:603-608, 1989). 
     Cyclin dependent kinases (cdks) play a key role in regulating the cell cycle machinery. These complexes consist of two components: a catalytic subunit (the kinase) and a regulatory subunit (the cyclin). To date, six kinase subunits (cdk 1-7) have been identified along with several regulatory subunits (cyclins A-H). Each kinase associates with a specific regulatory partner and together make up the active catalytic moiety. Each transition of the cell cycle is regulated by a particular cdk complex: G1/S by cdk2/cyclin E, cdk4/cyclin D1 and cdk6/cyclinD/2; S/G2 by cdk2/cyclin A and cdk1/cyclin A; G2/M by cdk1/B. The coordinated activity of these kinases guides the individual cells through the replication process and ensures the vitality of each subsequent generation (Sherr, Cell 73:1059-1065, 1993; Draetta, Trends Biochem. Sci. 15:378-382, 1990) 
     An increasing body of evidence has shown a link between tumor development and cdk related malfunctions. Over expression of the cyclin regulatory proteins and subsequent kinase hyperactivity have been linked to several types of cancers (Jiang, Proc. Natl. Acad. Sci. USA 90:9026-9030, 1993; Wang, Nature 343:555-557, 1990). More recently, endogenous, highly specific protein inhibitors of cdks were found to have a major affect on cellular proliferation (Kamb et al, Science 264:436-440, 1994; Beach, Nature 336:701-704, 1993). These inhibitors include p16 INK4  (an inhibitor of cdk4/D1), p21 CIP1  (a general cdk inhibitor), and p27 KIP1  (a specific cdk2/E inhibitor). A recent crystal structure of p27 bound to cdk2/A revealed how these proteins effectively inhibit the kinase activity through multiple interactions with the cdk complex (Pavletich, Nature 382:325-331, 1996). These proteins help to regulate the cell cycle through specific interactions with their corresponding cdk complexes. Cells deficient in these inhibitors are prone to unregulated growth and tumor formation. 
     This body of evidence has led to an intense search for small molecule inhibitors of the cdk family as an approach to cancer chemotherapy. 
     A series of indeno[1,2-c]pyrazoles having anticancer activity are described in JP 60130521 and JP 62099361 with the following generic structure:                           
     A series of indeno[1,2-c]pyrazoles having herbicidal activity are described in GB 2223946 with the following generic structure:                           
     A series of 1-(6′-substituted-4′-methylquinol-2′-yl)-3-methylindeno[1,2-c]pyrazoles having CNS activity are described by Quraishi, Farmaco 44:753-8, 1989 with the following generic structure:                           
     There is a continuing unmet need for cdk inhibitors with which to treat proliferative diseases. 
     SUMMARY OF THE INVENTION 
     The present invention describes a novel class of indeno[1,2-c]pyrazol-4-ones or pharmaceutically acceptable salt forms thereof that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk 1-7 and their regulatory subunits know as cyclins A-H. 
     The present invention is also directed to a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. 
     A novel method of treating cancer or other proliferative diseases, which comprises administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents is also described herein. 
     The present invention also describes compounds of formula (I):                           
     wherein R 1 , R 2  and X are defined below or pharmaceutically acceptable salts thereof as cyclin dependent kinase inhibitors. 
     DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS 
     The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. The inhibitors of this invention are indeno[1,2-c]pyrazol-4-one analogs. Certain analogs were selective for their activity against cdks and their cyclin bound complexes and were less active against other known serine/threonine kinases such as Protein Kinase A (PKA) and Protein Kinase C (PKC). In addition, these inhibitors were less active against tyrosine kinases such as c-Ab1. 
     As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently would be useful in modulating cell-cycle progression, which would ultimately control cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation, such as the treatment of cancer, psoriasis, immunological disorders involving unwanted leukocyte proliferation, in the treatment of restinosis and other smooth muscle cell disorders, and the like. 
     The present invention, in a first embodiment, describes a novel compound of formula (I):                           
     or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein: 
     X is selected from the group: O, S, and NR; 
     R is selected from the group: H, C 1-4  alkyl, and NR 5 R 5a ; 
     R 1  is selected from the group: H, C 1-10  alkyl substituted with 0-3 R c , C 2-10  alkenyl substituted with 0-3 R c , C 2-10  alkynyl substituted with 0-3 R c , C 1-10  alkoxy, —NHR 4 , C 3-10  carbocycle substituted with 0-5 R a , and 3-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S and substituted with 0-5 R b ; 
     R 2  is selected from the group: H, C 1-10  alkyl substituted with 0-3 R c , C 2-10  alkenyl substituted with 0-3 R c , C 2-10  alkynyl substituted with 0-3 R c , —(CF 2 ) m CF 3 , C 3-10  carbocycle substituted with 0-5 R a , and 3-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S and substituted with 0-5 R b ; 
     R 3  is selected from the group: H, halo, —CN, NO 2 , C 1-4  haloalkyl, NR 5 R 5a , NR 5 NR 5 R 5a , NR 5 C(O)OR 5 , NR 5 C(O)R 5 , ═O, OR 5 , COR 5 , CO 2 R 5 , CONR 5 R 5a , NHC(O)NR 5 R 5a , NHC(S)NR 5 R 5a , SO 2 NR 5 R 5a , SO 2 R 5b , C 1-4  alkyl, phenyl, benzyl, C 1-4  alkyl substituted with 1-3 R c , C 5-10  alkyl substituted with C 2-10  alkenyl optionally substituted with 0-3 R 6 , C 2-10  alkynyl substituted with 0-3 R 6 , —(CF 2 ) m CF 3 , C 3-10  carbocycle substituted with 0-5 R 6 , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R 6 ; and 
     provided that if R 3  is phenyl, it is substituted with 1-5 R a ; 
     R 4  is independently at each occurrence selected from the group: H, —CN, C 1-4  alkyl, C 1-4  haloalkyl, NR 3 R 3a , NR 3 C(O)OR 3 , NR 3 C(O)R 3 , OR 3 , COR 3 , CO 2 R 3 , CONR 3 R 3a , NHC(O)NR 3 R 3a , NHC(S)NR 3 R 3a , SO 2 NR 3 R 3a , SO 2 R 3b , C 3-10  carbocycle substituted with 0-5 R a , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R 3 ; 
     provided that at least one R 3  is present and that this R 3  is selected from the group: C 1-4  alkyl substituted with 1-3 R 6 , C 5-10  alkyl substituted with C 2-10  alkenyl optionally substituted with 0-3 R 6 , C 2-10  alkynyl substituted with 0-3 R 6 , —(CF 2 ) m CF 3 , C 3-10  carbocycle substituted with 0-5 R 6 , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R 6 ; 
     R a  is independently at each occurrence selected from the group: halo, —CN, N 3 , NO 2 , C 1-4  alkyl, C 1-4  haloalkyl, NR 3 R 3a , ═O, OR 3 , COR 3 , CO 2 R 3 , CONR 3 R 3a , NHC(O)NR 3 R 3a , NHC(S)NR 3 R 3a , NR 3 C(O)OR 3 , NR 3 C(O)R 3 , SO 2 NR 3 R 3a , SO 2 R 3b , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S; 
     alternatively, when two R 2 , are present on adjacent carbon atoms they combine to form —OCH 2 O— or —OCH 2 CH 2 O—; 
     R b  is independently at each occurrence selected from the group: halo, —CN, NO 2 , C 1-4  alkyl, C 1-4  haloalkyl, NR 3 R 3a , NR 3 C(O)OR 3 , NR 3 C(O)R 3 , OR 3 , COR 3 , CO 2 R 3 , CONR 3 R 3a , NHC(O)NR 3 R 3a , NHC(S)NR 3 R 3a , SO 2 NR 3 R 3a , and SO 2 R 3b ; 
     R c  is independently at each occurrence selected from the group: halo, —CN, NO 2 , C 1-4  alkyl, C 1-4  haloalkyl, NR 3 R 3a , NR 5 NR 5 R 5a , NR 3 C(O)OR 3 , NR 3 C(O)R 3 , ═O, OR 3 , COR 3 , CO 2 R 3 , CONR 3 R 3a , NHC(O)NR 3 R 3a , NHC(S)NR 3 R 3a , SO 2 NR 3 R 3a , SO 2 R 3b , C 3-10  carbocycle substituted with 0-5 R a , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R 3 ; 
     R 3a  is selected from the group: H, C 1-4  alkyl, phenyl, and benzyl; 
     alternatively, R 3  and R 3a , together with the nitrogen atom to which they are attached, form a heterocycle having 4-8 atoms in the ring containing an additional 0-1 N, S, or O atom and substituted with 0-3 R 3c ; 
     R 3b  is selected from the group: H, C 1-4  alkyl, phenyl, and benzyl; 
     R 3c  is independently at each occurrence selected from the group: halo, —CN, N 3 , NO 2 , C 1-4  alkyl, C 1-4  haloalkyl, NR 3 R 3b , ═O, OR 3 , COR 3 , CO 2 R 3 , CONR 3 R 3     b   , NHC(O)NR 3 R 3     b   , NHC(S)NR 3 R 3     b   , NR 3 C(O)OR 3 , NR 3 C(O)R 3 , SO 2 NR 3 R 3     b   , SO 2 R 3b , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S; 
     R 5  is independently selected from the group: H, C 1-4  alkyl, phenyl and benzyl; 
     R 5a  is independently selected from the group: H, C 1-4  alkyl, phenyl and benzyl; 
     R 5b  is independently selected from the group: H, C 1-4  alkyl, phenyl and benzyl; 
     R 6  is independently at each occurrence selected from the group: halo, —CN, NO 2 , C 1-4  alkyl, C 1-4  haloalkyl, NR 5 R 5 , NR 5 NR 5 R 5a , NR 5 C(O)OR 5 , NR 5 C(O)R 5 , ═O, OR 5 , COR 5 , CO 2 R 5 , CONR 5 R 5a , NHC(O)NR 5 R 5a , NHC(S)NR 5 R 5a , SO 2 NR 5 R 5a , SO 2 R 5b , C 3-10  carbocycle substituted with 0-5 R 5 , and 5-10 membered heterocycle containing from 1-4 heteroatoms selected from O, N, and S, substituted with 0-3 R 5 ; and 
     m is selected from 0, 1, 2, and 3. 
     In another embodiment of the present invention, the compounds of formula (I) are selected from: 
     3-(4-methoxyphenyl)-5-(2-benzoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-isonicotinoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-nictinoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(3,4-dihydroxybenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5(2-(4-hydroxybenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(3-aminobenzoyl) hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(4-aminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(2-aminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(4-N,N-dimethylaminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-phenethylacetylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     3-(4-methoxyphenyl)-5-(2-(2-hydroxybenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; and 
     3-(4-methoxyphenyl)-5-(2-methoxycarbonylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one; 
     1-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea; 
     [3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea; 
     1-(2-amino-cyclohexyl)-3-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea; 
     2-(4-aminomethyl-piperidin-1-yl)-N-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide; 
     1-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea. 
     or pharmaceutically acceptable salt form thereof. 
     Another embodiment of the present invention is a pharmaceutical composition comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of formula (I). 
     Another embodiment of the present invention is a method of treating cancer and proliferative diseases comprising: administering to a host in need of such treatment a therapeutically effective amount of a compound of formula (I), or a pharmaceutically effective salt form thereof. 
     DEFINITIONS 
     As used herein, the following terms and expressions have the indicated meanings. The compounds of the present invention may contain an asymmetrically substituted carbon atom, and may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. All chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomer form is specifically indicated. 
     The term “alkyl” is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms. Examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, t-butyl, n-pentyl, and s-pentyl. In addition, the term is intended to include both unsubstituted and substituted alkyl groups, the latter referring to alkyl moieties having one or more hydrogen substituents replaced by, but not limited to halogen, hydroxyl, carbonyl, alkoxy, ester, ether, cyano, phosphoryl, amino, imino, amido, sulfhydryl, alkythio, thioester, sulfonyl, nitro, heterocyclo, aryl or heteroaryl. It will also be understood by those skilled in the art that the substituted moieties themselves can be substituted as well when appropriate. 
     The terms “halo” or “halogen” as used herein refer to fluoro, chloro, bromo and iodo. The term “aryl” is intended to mean an aromatic moiety containing the specified number of carbon atoms, such as, but not limited to phenyl, indanyl or naphthyl. The terms “cycloalkyl” and “bicycloalkyl” are intended to mean any stable ring system, which may be saturated or partially unsaturated. Examples of such include, but are not limited to, cyclopropyl, cyclopentyl, cyclohexyl, norbornyl, bicyclo[2.2.2]nonane, adamantly, or tetrahydronaphthyl (tetralin). 
     As used herein, “carbocycle” or “carbocyclic residue” is intended to mean any stable 3- to 7-membered monocyclic or bicyclic or 7- to 13-membered bicyclic or tricyclic, any of which may be saturated, partially unsaturated, or aromatic. Examples of such carbocycles include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, cyclooctyl,; [3.3.0]bicyclooctane, [4.3.0]bicyclononane, [4.4.0]bicyclodecane (decalin), [2.2.2]bicyclooctane, fluorenyl, phenyl, naphthyl, indanyl, adamantyl, or tetrahydronaphthyl (tetralin). 
     As used herein, the term “heterocycle” or “heterocyclic system” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic ring which is saturated partially unsaturated or unsaturated (aromatic), and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The nitrogen and sulfur heteroatoms may optionally be oxidized. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. If specifically noted, a nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and O atoms in the heterocycle exceeds 1, then these heteroatoms are not adjacent to one another. It is preferred that the total number of S and O atoms in the heterocycle is not more than 1. As used herein, the term “aromatic heterocyclic system” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic aromatic ring which consists of carbon atoms and from 1 to 4 heterotams independently selected from the group consisting of N, O and S. It is preferred that the total number of S and O atoms in the aromatic heterocycle is not more than 1. 
     Examples of heterocycles include, but are not limited to, 1H-indazole, 2-pyrrolidonyl, 2H,6H-1,5,2-dithiazinyl, 2H-pyrrolyl, 3H-indolyl, 4-piperidonyl, 4aH-carbazole, 4H-quinolizinyl, 6H-1,2,5-thiadiazinyl, acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazalonyl, carbazolyl, 4aH-carbazolyl, b-carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H,6H-1,5,2-dithiazinyl, dihydrofuro[2,3-b]tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, morpholinyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl., oxazolyl, oxazolidinylperimidinyl, phenanthridinyl, phenanthrolinyl, phenarsazinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, piperidonyl, 4-piperidonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, carbolinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, triazinyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, xanthenyl. Preferred heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, indolyl, benzimidazolyl, 1H-indazolyl, oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl, or isatinoyl. Also included are fused ring and spiro compounds containing, for example, the above heterocycles. 
     As used herein, “pharmaceutically acceptable salts” refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like. 
     The pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in Remington&#39;s Pharmaceutical Sciences, 18th ed., Mack Publishing Company, Easton, Pa., 1990, p. 1445, the disclosure of which is hereby incorporated by reference. 
     The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication commensurate with a reasonable benefit/risk ratio. 
     “Prodrugs”, as the term is used herein, are intended to include any covalently bonded carriers which release an active parent drug of the present invention in vivo when such prodrug is administered to a mammalian subject. Since prodrugs are known to enhance numerous desirable qualities of pharmaceuticals (i.e., solubility, bioavailability, manufacturing, etc.) the compounds of the present invention may be delivered in prodrug form. Thus, the present invention is intended to cover prodrugs of the presently claimed compounds, methods of delivering the same, and compositions containing the same. Prodrugs of the present invention are prepared by modifying functional groups present in the compound in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compound. Prodrugs include compounds of the present invention wherein a hydroxy, amino, or sulfhydryl group is bonded to any group that, when the prodrug of the present invention is administered to a mammalian subject, it cleaves to form a free hydroxyl, free amino, or free sulfydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate, and benzoate derivatives of alcohol and amine functional groups in the compounds of the present invention. 
     “Substituted” is intended to indicate that one or more hydrogens on the atom indicated in the expression using “substituted” is replaced with a selection from the indicated group(s), provided that the indicated atom&#39;s normal valency is not exceeded, and that the substitution results in a stable compound. When a substituent is keto (i.e., ═O) group, then 2 hydrogens on the atom are replaced. 
     As used herein, the term “anti cancer” or “anti-proliferative” agent includes, but is not limited to, altretamine, busulfan, chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan, thiotepa, cladribine, fluorouracil, floxuridine, gemcitabine, thioguanine, pentostatin, methotrexate, 6-mercaptopurine, cytarabine, carmustine, lomustine, streptozotocin, carboplatin, cisplatin, oxaliplatin, iproplatin, tetraplatin, lobaplatin, JM216, JM335, fludarabine, aminoglutethimide, flutamide, goserelin, leuprolide, megestrol acetate, cyproterone acetate, tamoxifen, anastrozole, bicalutamide, dexamethasone, diethylstilbestrol, prednisone, bleomycin, dactinomycin, daunorubicin, doxirubicin, idarubicin, mitoxantrone, losoxantrone, mitomycin-c, plicamycin, paclitaxel, docetaxel, topotecan, irinotecan, 9-amino camptothecan, 9-nitro camptothecan, GS-211, etoposide, teniposide, vinblastine, vincristine, vinorelbine, procarbazine, asparaginase, pegaspargase, octreotide, estramustine, hydroxyurea. 
     SYNTHESIS 
     The compounds of the present invention can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or variations thereon as appreciated by those skilled in the art. Preferred methods include, but are not limited to, those methods described below. Each of the references cited below are hereby incorporated herein by reference.                           
     An approach to preparing indeno[1,2-c]pyrazol-4-ones is presented in Scheme 1 and can be used to prepare compounds of the present invention. The nitro group of dimethyl 3-nitrophthalate was reduced to the amine using catalytic hydrogenation. The aniline was acylated using acetic anhydride and pyridine as a base. A mixture of the resulting acetamide 2 and an acetophenone were treated with a strong base in an appropriate solvent at elevated temperature to give the desired triketone 3. Additional means of preparing triketones are known to one skilled in the art as described in Kilgore et al, Industrial and Engineering Chemistry 34:494-497, 1946, the contents of which are hereby incorporated herein by reference. The triketone was treated with hydrazine at elevated temperature in an appropriate solvent to give the indeno[1,2-c]pyrazol-4-one ring system. Additional means of preparing indeno[1,2-c]pyrazol-4-ones are known to one skilled in the art as described in Lemke et al., J. Heterocyclic Chem. 19:1335-1340, 1982; Mosher and Soeder, J. Heterocyclic Chem. 8:855-59, 1971; Hrnciar and Svanygova Collect. Czech. Chem. Commun. 59:2734-40, 1994 the contents of which are hereby incorporated herein by reference. The amide was deacylated by heating with a strong acid in an appropriate solvent to give aniline 4. This aniline was acylated under standard conditions using an acid chloride in an appropriate solvent to give the desired product 5.                          
     An alternative method for making compounds of the present invention is shown in Scheme 2. The intermediate triketone 3 can be deacylated with strong acid and reacylated with an appropriate acid chloride using methods known to those skilled in the art. Subsequently, triketone 6 can the be converted to the indeno[1,2-c]pyrazol-4-one ring system using the same conditions described previously in Scheme 1.                          
     Another method for preparing the triketones 6 of Scheme 2 employs the condensation of a 1,3-diketone 6a with 3-nitrophthalic anhydride as described in Rotberg and Oshkaya, Zh. Organ. Khim. 8:84-87, 1972; Zh. Organ. Khim. 9:2548-2550, 1973, the contents of which are hereby incorporated herein by reference. The 1,3-diketones, when not commercially available can be readily prepared by one skilled in the art by the acetylation or trifluoroacetylation of the requisite methyl ketone, R 1 COCH 3 . Reduction of the nitro derivative 6b to the aniline 6c can be accomplished in a variety of ways including catalyic hydrogenation, treatment with zinc or iron under acidic conditions, or treatment with other reducing agents such as sodium dithionite or stannous chloride. Subsequently the aniline 6c can be converted to the indeno[1,2-c]pyrazol-4-ones of this invention by acylation followed by treatment with hydrazine as described previously in Scheme 2.                          
     Another method for making the indeno[1,2-c]pyrazol-4-one ring system is shown in Scheme 4. Dimethyl hydrazine was reacted with 3-acetylpyridine with no solvent to give the hydrazone 7. This was treated in a similar fashion as described in Scheme 1 to give the desired intermediate 8. Additional means of preparing similar intermediates are known to one skilled in the art as described in Rappoport, J. Org. Chem. 49:2948-2953, 1984, the contents of which are hereby incorporated herein by reference. This intermediate was carried through the sequence in a similar fashion as described in Scheme 1.                          
     Another approach to preparing indeno[1,2-c]pyrazol-4-ones is presented in Scheme 5 and can be used to prepare compounds of the present invention. Treating the intermediate 5-aminoindeno[1,2-c]pyrazol-4-one with 2-(trimethylsilyl) ethoxymethylmethyl chloride (SEMCl) and a suitable base in an inert solvent under reflux gives the SEM protected intermediate. The aniline is converted to the carbamate with phenylchloroformate using methods known to those skilled in the art. This intermediate is reacted with carbaztes in DMSO at elevated temperatures and then the SEM group is removed by treating with acid in a polar protic solvent to give the desired acylsemicarbazide-containing indenopyrazole analogs. 
     Other features of the invention will become apparent during the following descriptions of exemplary embodiments which are given for illustration of the invention and are not intended to be limiting thereof. 
    
    
     EXAMPLES 
     Abbreviations used in the Examples are defined as follows: “°C.” for degrees Celsius, “CIMS” for chemical ionization mass spectroscopy, “eq” for equivalent or equivalents, “g” for gram or grams, “h” for hour or hours, “mg” for milligram or milligrams, “mL” for milliliter or milliliters, “mmol” for millimolar, “M” for molar, “min” for minute or minutes, “p-TsOH” for para-toluenesulphonic acid, “DMF” for dimethylformamide, and “TFA” for trifluoroacetic acid. 
     Example I 
     Preparation of 3-(4-methoxyphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 2 from Dimethyl 3-nitrophthalate. 
     A solution of dimethyl 3-nitrophthalate (25 g, 105 mmol) in methanol (100 mL) was treated with 5% Pd/C (2.5 g) and hydrogenated on a Parr Shaker at 50 psi for 2 h. The solution was filtered (Celite), the filtrate collected and the solvent removed at reduced pressure. The residue was dissolved in acetic anhydride (20 mL) treated with pyridine (0.05 mL) and heated to 80° C. for 1 min. The reaction was cooled and stirred at 25° C. for 2 h. The solvent was removed at reduced pressure and the residue recrystallized from ethanol to give the product as a white solid (21 g, 79%). mp 104-105° C.; CIMS m/e calc&#39;d for C 12 H 14 NO 5 : 252.0872, found 252.0888; Analysis calc&#39;d for C 12 H 13 NO 5 : C, 57.37; H, 5.22; N, 5.58; found: C, 57.67; H, 5.29; N, 5.77. 
     Step 2. Synthesis of Triketone 11 from 2. 
     A solution of 2 (1 g, 4.0 mmol) in dry DMF (2 mL) was treated with sodium hydride (0.15 g, 60% suspension in oil, 0.4 mmol) in one portion. After 1 h, 4-methoxyacetophenone (0.6 g, 4.0 mmol) was added in one portion and the reaction heated to 90° C. A second portion of sodium hydride (0.15 g, 60% suspension in oil, 0.4 mmol) was added and the exothermic reaction turns deep red. After 20 min, the reaction was cooled to 25° C. diluted with water (20 mL), extracted with EtOAc (10 mL) and the aqueous phase separated. The aqueous phase was acidified with 2 N HCl to pH 2 and the crude product collected. Recrystalization with ethanol gave the desired product as a yellow solid (0.4 g, 30%). mp 174-175° C.; CIMS m/e calc&#39;d for C 19 H 16 NO 5 : 338.1028, found 338.1022; Analysis calc&#39;d for C 19 H 15 NO 5 : C, 67.65; H, 4.48; N, 4.15; found: C, 67.87; H, 4.29; N, 3.99. 
     Step 3. Synthesis of 12 from 11. 
     A solution of 11 (0.2 g, 0.6 mmol) in EtOH (5 mL) was treated with hydrazine hydrate (0.1 mL, 1.8 mmol) and p-TsOH (3 mg). The reaction was heated to reflux and stirred for 2 h. The reaction was cooled to 25° C. and the product collected as a yellow solid (0.1 g, 50%). mp 268° C.; CIMS m/e calc&#39;d for C 19 H 16 N 3 O 3 : 334.1192, found: 334.1168; Analysis calc&#39;d for C 19 H 15 N 3 O 3 : C, 68.46; H, 4.54; N, 12.61; found: C, 68.81; H, 4.39; N, 12.45. 
     Example II 
     Preparation of 3-(4-methoxyphenyl)-5-(chloroacetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 13 from 12. 
     A suspension of 12 (1.0 g, 3.0 mmol) in MeOH (10 mL) was treated with conc. HCl (1 mL) and heated to reflux. After 2 h, the reaction was cooled and the product was collected as a greenish solid (0.7 g, 81%). mp 273° C.; CIMS m/e calc&#39;d for C 17 H 13 N 3 O 2 :292.1086, found: 292.1080; Analysis calc&#39;d for C 17 H 14 N 3 O 2 : C, 69.85; H, 4.83; N, 14.37; found: C, 69.99; H, 4.59; N, 14.44. 
     Step 2. Synthesis of 14 from 13. 
     A suspension of 13 (20 mg, 0.07 mmol) in dioxane (2 mL) was treated with aqueous sat. NaHCO 3  (1 mL) and chloroacetyl chloride (30 mL, 0.21 mmol). The reaction was heated to 50° C. and stirred for 2 h. The reaction was cooled, poured into water (2 mL), extracted with EtOAc (10 mL), the organic layer separated, dried (MgSO 4 ) and the solvent removed at reduced pressure. The solid residue was recrystallized from EtOH to give the product as a yellow solid (9 mg, 35%). mp 274° C.; CIMS m/e calc&#39;d for C 19 H 15 N 3 O 3 Cl: 368.0802, found: 368.0818. 
     Example III 
     Preparation of 3-(4-methoxyphenyl)-5-(cyclopropylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using cyclopropylacetyl chloride as the starting material. mp 289° C.; CIMS m/e calc&#39;d for C 21 H 18 N 3 O 3 : 360.1348, found: 360.1330. 
     Example IV 
     Preparation of 3-(4-methoxyphenyl)-5-(isopropylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using isopropylacetyl chloride as the starting material. mp 288° C.; CIMS m/e calc&#39;d for C 21 H 20 N 3 O 3 : 362.1505, found: 362.1535. 
     Example V 
     Preparation of 3-(4-methoxyphenyl)-5-(ethylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using propionyl chloride as the starting material. mp 287 ° C.; CIMS m/e calc&#39;d for C 20 H 18 N 3 O 3 : 348.1348, found: 348.1313. 
     Example VI 
     Preparation of 3-(4-methoxyphenyl)-5-(cyclopentylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using cyclopentylacetyl chloride as the starting material. mp 267° C.; CIMS m/e calc&#39;d for C 23 H 22 N 3 O 3 : 388.1661, found: 388.1626. 
     Example VII 
     Preparation of 3-(4-methoxyphenyl)-5-(cyclobutylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using cyclobutylacetyl chloride as the starting material. mp 297° C.; CIMS m/e calc&#39;d for C 22 H 20 N 3 O 3 : 374.1505, found: 374.1530. 
     Example VIII 
     Preparation of 3-(4-methoxyphenyl)-5-(phenylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using phenylacetyl chloride as the starting material. mp 280° C.; CIMS m/e calc&#39;d for C 25 H 20 N 3 O 3 : 410.1505, found: 410.1533. 
     Example IX 
     Preparation of 3-(4-methoxyphenyl)-5-(butylamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using butyryl chloride as the starting material. mp 282° C.; CIMS m/e calc&#39;d for C 21 H 20 N 3 O 3 : 362.1505, found: 362.1500. 
     Example X 
     Preparation of 3-(4-methoxyphenyl)-5-((4-chlorophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using 4-chlorophenylacetyl chloride as the starting material. mp 238° C.; CIMS m/e calc&#39;d for C 25 H 19 N 3 O 3 Cl: 444.1115, found: 444.1110. 
     Example XI 
     Preparation of 3-(4-methoxyphenyl)-5-((3-methoxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using 3-methoxyphenylacetyl chloride as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 26 H 22 N 3 O 4 : 440.1610, found: 440.1620. 
     Example XII 
     Preparation of 3-(4-methoxyphenyl)-5-((4-methoxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using 4-methoxyphenylacetyl chloride as the starting material. mp 280° C.; CIMS m/e calc&#39;d for C 26 H 22 N 3 O 4 : 440.1610, found: 440.1630. 
     Example XIII 
     Preparation of 3-(4-methoxyphenyl)-5-((3,4-dimethoxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using 3,4-dimethoxyphenylacetyl chloride as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 27 H 24 N 3 O 5 : 470.1716, found: 470.1731. 
     Example XIV 
     Preparation of 3-(4-methoxyphenyl)-5-((2,5-dimethoxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example II using 2,5-dimethoxyphenylacetyl chloride as the starting material. mp 226° C.; CIMS m/e calc&#39;d for C 27 H 24 N 3 O 5 : 470.1716, found: 470.1739. 
     Example XV 
     Preparation of 3-(2-methoxyphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 2-methoxyacetophenone as the starting material. mp 276° C.; CIMS m/e calc&#39;d for C 19 H 16 N 3 O 3 : 334.1192, found: 334.1169. 
     Example XVI 
     Preparation of 3-(3,4-dimethoxyphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 3,4-dimethoxyacetophenone as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 20 H 18 N 3 O 4 : 364.1297, found: 364.1288. 
     Example XVII 
     Preparation of 3-(4-methoxyphenyl)-5-((3,4-ethylenedioxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 15 from 11. 
     A suspension of 11 (5 g, 14.8 mmol) in MeOH (50 mL) was treated with conc. HCl (3 mL) and heated to reflux. After stirring for 2 h, the reaction was cooled to 0° C. and the product collected as a yellow solid (4.2 g, 96%). mp 173° C.; CIMS m/e calc&#39;d for C 17 H 14 NO 4 : 296.0923, Found: 296.0901. 
     Step 2. Synthesis of 16 from 15. 
     A suspension of 15 (20 mg, 0.07 mmol) in acetone (2 mL) was treated with NaHCO 3  (10 mg) and the acid chloride of (3,4-methylenedioxyphenyl)acetic acid (prepared by heating the acid in a benzene:thionyl chloride 4:1 mixture at 50° C. for 2 h, removing the volatile components at reduced pressure, and using the crude acid chloride without further purification). The reaction was heated to 50° C. and stirred for 2 h. The reaction was cooled, poured into water (4 mL), extracted with EtOAc (10 mL), dried (MgSO 4 ), filtered and concentrated. The crude triketone was suspended in EtOH (2 mL), treated with hydrazine hydrate (0.05 mL) and p-TsOH (1 mg) and heated to reflux for 2 h. The reaction was cooled to 0° C. and the product filtered to give a yellow solid (6.5 mg, 20%). mp 297° C.; CIMS m/e calc&#39;d for C 26 H 20 N 3 O 5 : 454.1403, Found: 454.1398. 
     Example XVIII 
     Preparation of 3-(4-dimethoxyphenyl)-5-((3-thiophene)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XVII using the acid chloride of 3-thiopheneacetic acid as the starting material. mp 293° C.; CIMS m/e calc&#39;d for C 23 H 18 N 3 O 3 S: 416.1069, found: 416.1088. 
     Example XIX 
     Preparation of 3-(4-methoxyphenyl)-5-((2-methoxyphenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XVII using the acid chloride of 2-methoxyphenylacetic acid as the starting material. mp 255° C.; CIMS m/e calc&#39;d for C 26 H 22 N 3 O 4 : 440.1610, found: 440.1622. 
     Example XX 
     Preparation of 3-(4-methoxyphenyl)-5-((3,4-dichlorophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XVII using the acid chloride of 3,4-dichlorophenylacetic acid as the starting material. mp 299° C.; CIMS m/e calc&#39;d for C 25 H 18 N 3 O 3 Cl 2 : 478.0725, found: 478.0744. 
     Example XXI 
     Preparation of 3-(4-methoxyphenyl)-5-((2,4-dichlorophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XVII using the acid chloride of 2,4-dichlorophenylacetic acid as the starting material. mp 286° C.; CIMS m/e calc&#39;d for C 25 H 18 N 3 O 3 Cl 2 : 478.0725, found: 478.0734. 
     Example XXII 
     Preparation of 3-(4-methoxyphenyl)-5-((2-chlorophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XVII using the acid chloride of 2-chlorophenylacetic acid as the starting material. mp 300° C.; CIMS m/e calc&#39;d for C 25 H 19 N 3 O 3 Cl: 444.1115, found: 444.1111. 
     Example XXIII 
     Preparation of 3-(4-methoxyphenyl)-5-(aminoacetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     A suspension of 14 (15 mg, 0.04 mmol) in EtOH (1 mL) was treated with conc. NH 4 OH (1 mL), placed in a sealed tube and heated to 80° C. for 3 h. The reaction was cooled and the solvent removed at reduced pressure. The residue was recrystallized from EtOH to give the product as a yellow solid (9 mg, 62%). mp &gt;300° C.; CIMS m/e calc&#39;d for C 20 H 19 N 4 O 3 : 363.1457, Found: 363.1431. 
     Example XXIV 
     Preparation of 3-(4-methoxyphenyl)-5-((2-hydroxyethyl)aminoacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using hydroxylamine as the starting material. mp 243° C.; CIMS m/e calc&#39;d for C 21 H 21 N 4 O 4 : 393.1563, found: 393.1539. 
     Example XXV 
     Preparation of 3-(4-methoxyphenyl)-5-(N,N-dimethylaminoacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using dimethylamine as the starting material. mp 279° C.; CIMS m/e calc&#39;d for C 21 H 21 N 4 O 3 : 377.1614, found: 377.1640. 
     Example XXVI 
     Preparation of 3-(4-methoxyphenyl)-5-(piperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using piperazine as the starting material. mp 277° C.; CIMS m/e calc&#39;d for C 23 H 24 N 5 O 3 : 418.1879, found: 418.1899. 
     Example XXVII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-methylpiperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-methylpiperizine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 26 N 5 O 3 : 432.2036, found: 432.2030. 
     Example XXVIII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-(2-hydroxyethyl)piperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-hydroxyethylpiperizine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 28 N 5 O 4 : 462.2141, found: 462.2128. 
     Example XXIX 
     Preparation of 3-(4-methoxyphenyl)-5-(piperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using piperidine as the starting material. mp 291° C.; CIMS m/e calc&#39;d for C 24 H 25 N 4 O 3 : 417.1927, found: 417.1955. 
     Example XXX 
     Preparation of 3-(4-methoxyphenyl)-5-(4-aminomethylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-aminomethylpiperidine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 28 N 5 O 3 : 446.2192, found: 446.2166. 
     Example XXXI 
     Preparation of 3-(4-methoxyphenyl)-5-(ethylaminoacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using ethylamine as the starting material. mp 250° C.; CIMS m/e calc&#39;d for C 21 H 21 N 4 O 3 : 377.1614, found: 377.1644. 
     Example XXXII 
     Preparation of 3-(4-methoxyphenyl)-5-(thiomorpholinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using thiomorpholine as the starting material. mp 298° C.; CIMS m/e calc&#39;d for C 23 H 23 N 4 O 3 S: 435.1491, found: 435.1477. 
     Example XXXIII 
     Preparation of 3-(4-methoxyphenyl)-5-(morpholinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using morpholine as the starting material. mp 295° C.; CIMS m/e calc&#39;d for C 23 H 23 N 4 O 4 : 419.1719, found: 419.1744. 
     Example XXXIV 
     Preparation of 3-(4-methoxyphenyl)-5-(pyrrolidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using pyyrolidine as the starting material. mp 279° C.; CIMS m/e calc&#39;d for C 23 H 23 N 4 O 3 : 403.1770, found: 403.1761. 
     Example XXXV 
     Preparation of 3-(4-methoxyphenyl)-5-(4-pyridinylaminomethylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-aminomethylpyridine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 22 N 5 O 3 : 440.1723, found: 440.1762. 
     Example XXXVI 
     Preparation of 3-(4-methoxyphenyl)-5-((4-acetamidophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     A suspension of 18 (10 mg, 0.02 mmol) in dioxane (1 mL) was treated with aqueous sat. NaHCO 3  (0.5 mL) and acetyl chloride (0.01 mL) and heated at 50° C. for 1 h. The reaction was cooled, poured into water (5 mL), extracted with EtOAc (10 mL), the organic layer separated, dried (MgSO 4 ) and the solvent removed at reduced pressure. The residue was recrystallized from EtOH to give the product as a yellow solid (5.6 mg, 61%). mp 268° C.; CIMS m/e calc&#39;d for C 27 H 23 N 4 O 4 : 467.1719, Found: 467.1730. 
     Example XXXVII 
     Preparation of 3-(4-methoxyphenyl)-5-((4-methoxycarbonylaminophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXXII using methylchloroformate as the starting material. mp 257° C.; CIMS m/e calc&#39;d for C 27 H 23 N 4 O 5 : 483.1668, found: 483.1633. 
     Example XXXVIII 
     Preparation of 3-(4-methoxyphenyl)-5-((4-aminomethylcarbonylaminophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII and XXXII using chloroacetyl chloride and conc. NH 4 OH as the starting materias. mp 228° C.; CIMS m/e calc&#39;d for C 27 H 24 N 5 O 4 : 482.1828, found: 482.1844. 
     Example XXXIX 
     Preparation of 3-(4-methoxyphenyl)-5-((4-N,N-dimethylaminomethylcarbonylaminophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII and XXXII using chloroacetyl chloride and dimethyl amine as the starting materias. mp &gt;300° C.; CIMS m/e calc&#39;d for C 29 H 28 N 5 O 4 : 510.2141, found: 510.2121. 
     Example XL 
     Preparation of 3-(4-methoxyphenyl)-5-((4-azidophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     A solution of example XXXVI (20 mg, 0.04 mmol) in DMF (2 mL) was treated with 5% palladium on carbon (5 mg) and hydrogentaed at atmospheric pressure using a hydrogen baloon. After 2 h, the solution was filtered (Celite), and the solvent removed at reduced pressure. The residue was recrystallized from EtOH to give the product as a yellow solid (15 mg, 78%). mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 19 N 6 O 3 : 451.1519, found: 451.1544. 
     Example XLI 
     Preparation of 3-(4-methoxyphenyl)-5-((4-aminophenyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXVII using the acid chloride of 4-azidophenylacetic acid as the starting material. mp 283° C.; CIMS m/e calc&#39;d for C 25 H 21 N 4 O 3 : 425.1614, found: 425.1643. 
     Example XLII 
     Preparation of 3-(4-methoxyphenyl)-5-(phenylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 20 from 15. 
     A suspension of 15 (0.5 g, 1.7 mmol) in acetone (10 mL) was treated with NaHCO 3  (0.5 g) and phenyl chloroformate. The mixture was heated to 50° C. for 2 h. The reaction was cooled, poured into water (20 mL), extracted with EtOAc (40 mL), the organic layer separated, dried (MgSO 4 ) and the solvent removed at reduced pressure. The residue was suspended in EtOH (10 mL) and treated with hydrazine hydrate (0.16 mL, 5.1 mmol) and p-TsOH (10 mg). The mixture was heated to reflux and stirred for 3 h. The reaction was cooled to 0° C. and the product collected as a yellow solid (0.25 g, 36%). mp 195° C.; CIMS m/e calc&#39;d for C 24 H 18 N 3 O 4 : 412.1297, Found: 412.1308. 
     Step 2. Synthesis of 21 from 20. 
     A solution of 20 (20 mg, 0.05 mmol) in DMSO (2 mL) was treated with aniline (20 mL, mmol) and dimethylaminopyridine (1 mg). The mixture was heated to 80° C. for 2 h. The reaction was cooled, poured into water (4 mL), extracted with EtOAc (15 mL), the organic layer separated, dried (MgSO 4 ) and the solvent removed at reduced pressure. The residue was recrystallized from EtOH to give the product as a yellow solid (9 mg, 44%). mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 19 N 4 O 3 : 411.1457, Found: 411.1432. 
     Example XLIII 
     Preparation of 3-(4-methoxyphenyl)-5-(butylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using butyl amine as the starting material. mp 252° C.; CIMS m/e calc&#39;d for C 21 H 21 N 4 O 3 : 377.1614, found: 377.1633. 
     Example XLIV 
     Preparation of 3-(4-methoxyphenyl)-5-(4-aminobenzylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using 4-aminobenzyl amine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 22 N 5 O 3 : 440.1723, found: 440.1700. 
     Example XLV 
     Preparation of 3-(4-methoxyphenyl)-5-(4-pyridylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using 4-aminomethylpyridine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 20 N 5 O 3 : 426.1566, found: 426.1533. 
     Example XLVI 
     Preparation of 3-(4-hydroxyphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     A suspension of 12 (20 mg, 0.07 mmol) in CH 2 Cl 2  (2 mL) was treated with excess BBr 3  (1.0 mL, 1.0 M in CH 2 Cl 2 ) and stirred for 20 h. The reaction was slowly poured into aqueous sat. NaHCO 3  (5 mL), extracted with EtOAc (10 mL), dried (MgSO 4 ) and concentrated. The residue was recrystallized from EtOH to give the desired product as a yellow solid (7.5 mg, 33%). mp &gt;300° C.; CIMS m/e calc&#39;d for C 18 H 14 N 3 O 3 : 320.1035, Found: 320.1050. 
     Example XLVII 
     Preparation of 3-(4-methoxyphenyl)-5-(formamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     A suspension of 13 (20 mg, 0.06 mmol) in formic acid (2 mL) was heated to 100° C. for 2 h. The reaction mixture was cooled and the solvent removed at reduced pressure. The residue was recrystallized from EtOH to give the desired product as a yellow solid (12 mg, 63%). mp 280° C.; CIMS m/e calc&#39;d for C 18 H 14 N 3 O 3 : 320.1035, Found: 320.1040. 
     Example XLVIII 
     Preparation of 3-(3-pyridyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 24 from 3-acetylpyridine. 
     A solution of 3-acetylpyridine (1.0 g, 8.3 mmol) in benzene (3 mL) was treated with 1,1-dimethylhydrazine (0.62 mL, 8.3 mmol) and p-TsOH (5 mg). The mixture was heated to 85° C. and stirred for 3 h. The reaction was cooled and the solvent removed at reduced pressure. This crude hydrazone was treated with 1.0 M NaN(TMS) 2  in THF (16.6 mL, 16.6 mmol) at 25° C. over 5 min. After 30 min dimethyl 3-acetamidophthalate (2.1 g, 8.3 mmol) was added in one portion and the reaction heated to reflux. Stirring was continued for 6 h. The reaction was cooled and quenched by the slow addition of TFA. The solvent was removed at reduced pressure and the residue chromatographed (silica, 2.5-5% MeOH/CH 2 Cl 2 ) to give the product as a yellow solid (0.35 g, 14%). mp 265° C.; CIMS m/e calc&#39;d for C 17 H 13 N 2 O 4 : 309.0875, Found: 309.0888. 
     Step 2. Synthesis of 25 from 24. 
     A suspension of 24 (30 mg, 0.09 mmol) in EtOH (2 mL) was treated with hydrazine hydrate (0.05 mL) and p-TsOH (1 mg) and heated to reflux. After stirring for 2 h. the reaction was cooled and the product filtered to give a yellow solid (12 mg, 44%). mp &gt;300° C.; CIMS m/e calc&#39;d for C 17 H 13 N 4 O 2 : 305.1039, Found: 305.1048. 
     Example XLIX 
     Preparation of 3-(4-pyridyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLVIII using 4-acetylpyridine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 17 H 13 N 4 O 2 : 305.1039, found: 305.1046. 
     Example L 
     Preparation of 3-(4-pyridyl)-5-(formamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLVII using 4-acetylpyridine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 16 H 11 N 4 O 2 : 291.0882, found: 291.0882. 
     Example LI 
     Preparation of 3-phenyl-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using acetophenone as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 18 H 13 N 3 O 2 : 304.1065, found: 304.1086. 
     Example LII 
     Preparation of 3-(4-methylthiophenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-methylthioacetophenone as the starting material. mp 283° C.; CIMS m/e calc&#39;d for C 19 H 15 N 3 O 2 S: 350.0956, found: 350.0963. 
     Example LIII 
     Preparation of 3-(4-methylsulphonylphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared by oxidation of the product of example LII. mp &gt;300° C.; CIMS m/e calc&#39;d for C 19 H 15 N 3 O 4 S: 382.0860, found: 382.0862. 
     Example LIV 
     Preparation of 3-(4-N,N-dimethylaminophenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-N,N,-dimethylaminoacetophenone as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 20 H 18 N 4 O 2 : 347.1496, found: 347.1508. 
     Example LV 
     Preparation of 3-(4-N,N-dimethylaminophenyl)-5-(morpholinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LIV and morpholine as the starting materials. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 26 N 5 O 3 : 432.2036, found: 432.2020. 
     Example LVI 
     Preparation of 3-(4-N,N-dimethylaminophenyl)-5-(dimethylaminoacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LIV and dimethylamine as the starting materials. mp &gt;300° C.; CIMS m/e calc&#39;d for C 22 H 24 N 5 O 2 : 390.1930, found: 390.1948. 
     Example LVII 
     Preparation of 3-(4-(1-piperidinyl)phenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-(1-piperidinyl)acetophenone as the starting material. mp 291° C.; CIMS m/e calc&#39;d for C 23 H 22 N 4 O 2 : 387.1801, found: 387.1821. 
     Example LVIII 
     Preparation of 3-(4-morpholinyl)phenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-morpholinylacetophenone as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 22 H 20 N 4 O 3 : 388.1528, found: 388.1535. 
     Example LIX 
     Preparation of 3-(4-ethoxyphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-ethoxyacetophenone as the starting material. mp 288° C.; CIMS m/e calc&#39;d for C 20 H 17 N 3 O 3 : 348.1325, found: 348.1348. 
     Example LX 
     Preparation of 3-(4-butylphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-butylacetophenone as the starting material. mp 259° C.; CIMS m/e calc&#39;d for C 22 H 21 N 3 O 2 : 360.1701, found: 360.1712. 
     Example LXI 
     Preparation of 3-(4-ethylphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-ethylacetophenone as the starting material. mp 294° C.; CIMS m/e calc&#39;d for C 20 H 17 N 3 O 2 : 331.1310, found: 331.1321. 
     Example LXII 
     Preparation of 3-(4-n-propylphenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example I using 4′-n-propylacetophenone as the starting material. mp 269° C.; CIMS m/e calc&#39;d for C 21 H 19 N 3 O 2 : 346.1555, found: 346.1554. 
     Example LXIII 
     Preparation of 3-(4-methoxyphenyl)-5-carbamoylaminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using concentrated ammonium hydroxide as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 18 H 15 N 4 O 3 : 335.1144, found: 335.1113. 
     Example LXIV 
     Preparation of 3-(4-methoxyphenyl)-5-(dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using dimethylamino hydrazine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 20 H 20 N 5 O 3 : 378.1566, found: 378.1555. 
     Example LXV 
     Preparation of 3-(4-methoxyphenyl)-5-(methylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using methylamine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 19 H 17 N 4 O 3 : 349.1300, found: 349.1311. 
     Example LXVI 
     Preparation of 3-(4-methoxyphenyl)-5-(morpholinocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using N-aminomorpholine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 22 H 22 N 5 O 4 : 420.1671, found: 420.1655. 
     Example LXVII 
     Preparation of 3-(4-methoxyphenyl)-5-(cis-2-aminocyclohexanylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using cis-1,2-diaminocyclohexane as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 26 N 5 O 3 : 432.2035, found: 432.2020. 
     Example LXVIII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-methylpiperazinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XLII using (4-amino)methylpiperazine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 23 H 25 N 6 O 3 : 433.1987, found: 433.1999. 
     Example LXIX 
     Preparation of 3-(4-methoxyphenyl)-5-(4-uridomethylpiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using example XXX as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 26 H 29 N 6 O 4 : 489.2250, found: 489.2209. 
     Example LXX 
     Preparation of 3-(4-methoxyphenyl)-5-(4-(2-pyridyl)piperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(2-pyridyl)piperazine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 28 H 27 N 6 O 3 : 495.2144, found: 495.2111. 
     Example LXXI 
     Preparation of 3-(4-methoxyphenyl)-5-(4-(aminoethyl)piperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(aminoethyl)piperazine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 29 N 6 O 3 : 461.2300, found: 461.2333. 
     Example LXXII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-amidopiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using isonipecotamide as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 26 N 5 O 4 : 460.1984, found: 460.1998. 
     Example LXXIII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-hydroxypiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-hydroxypiperadine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 25 N 4 O 4 : 433.1875, found: 433.1844. 
     Example LXXIV 
     Preparation of 3-(4-methoxyphenyl)-5-(4-hydroxmethylypiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-hydroxmethylypiperadine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 27 N 4 O 4 : 447.2032, found: 447.2002. 
     Example LXXV 
     Preparation of 3-(4-methoxyphenyl)-5-(4-amidopiperazinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-amidopiperazine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 25 N 6 O 6 : 493.1835, found: 493.1802. 
     Example LXXVI 
     Preparation of 3-(4-methoxyphenyl)-5-(4-dimethylaminopiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-dimethylaminopiperadine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 26 H 30 N 5 O 5 : 492.2246, found: 492.2220. 
     Example LXXVII 
     Preparation of 3-(4-methoxyphenyl)-5-(4-aminopiperadinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-aminopiperadine as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 24 H 26 N 5 O 5 : 464.1933, found: 464.1975. 
     Example LXXVIII 
     Preparation of 3-(4-(dimethylamino)phenyl)-5-((4-methyl-1-piperazinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LIV and 1-methylpiperazine as the starting materials. mp &gt;300° C.; ESI-MS m/e calc&#39;d for C 25 H 29 N 6 O 2 : 445.2352, found: 445.2359. 
     Example LXXIX 
     Preparation of 3-(4-(dimethylamino)phenyl)-5-((4-amino methyl-1-piperidinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LIV and 4-(aminomethyl)piperidine as the starting materials. ESI-MS m/e calc&#39;d for C 26 H 31 N 6 O 2 : 459.2508, found: 459.2508. 
     Example LXXX 
     Preparation of 3-(4-(dimethylamino)phenyl)-5-((4-hydroxy-1-piperidinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LIV and 4-hydroxypiperidine as the starting materials. mp 267° C.; ESI-MS m/e calc&#39;d for C 25 H 28 N 5 O 3 : 446.2192, found: 446.2206. 
     Example LXXXI 
     Preparation of 3-(4-(4-morpholinyl)phenyl)-5-(4-morpholinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LVIII and morpholine as the starting materials. mp 258° C.; ESI-MS m/e calc&#39;d for C 26 H 28 N 5 O 4 : 474.2141, found: 474.2151. 
     Example LXXXII 
     Preparation of 3-(4-(4-morpholinyl)phenyl)-5-((4-methyl-1-piperazinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LVIII and 1-methylpiperazine as the starting materials. mp 258° C.; ESI-MS m/e calc&#39;d for C 27 H 31 N 6 O 3 : 487.2457, found: 487.2447. 
     Example LXXXIII 
     Preparation of 3-(4-(4-morpholinyl)phenyl)-5-((4-hydroxy-1-piperidinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LVIII and 4-hydroxypiperidine as the starting materials. mp 245° C.; ESI-MS m/e calc&#39;d for C 27 H 30 N 5 O 4 : 488.2298, found: 488.2290. 
     Example LXXXIV 
     Preparation of 3-(4-(4-morpholinyl)phenyl)-5-((4-amino methyl-1-piperidinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples II and XXIII employing the product of example LVIII and 4-(aminomethyl)piperidine as the starting materials. mp 240° C.; ESI-MS m/e calc&#39;d for C 28 H 33 N 6 O 3 : 501.2614, found: 501.2619. 
     Example LXXXV 
     Preparation of 3-(4-(dimethylamino)phenyl)-5-((((4-methyl-1-piperazinyl)amino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples I, XXVII, and XLII employing the 4-(dimethylamino) acetophenone and 1-amino-4-methylpiperazine as the starting materials. mp &gt;300° C.; ESI-MS m/e calc&#39;d for C 24 H 28 N 7 O 2 : 446.2304, found: 446.2310. 
     Example LXXXVI 
     Preparation of 3-(i-propyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 26 from 3-nitrophthalic Anhydride. 
     A solution of 3-nitrophthalic anhydride (9.7 g, 50 mmol) and 1,1,1-trifluoro-5-methyl-2,4-hexanedione (9.1 g, 50 mmol) in acetic anhydride (28.3 mL, 300 mmol) was treated with triethylamine (13.95 mL, 100 mmol) and stirred at 25° C. for 4 h. The solution was diluted with 1 N HCl (200 mL) and the precipate collected and washed with water (200 mL) and hexane (400 mL) to give the product as a yellow solid (11.1 g, 85%). mp 127-129° C.; CIMS (M+H) calc&#39;d for C 13 H 12 NO 5 : 262.0715, found: 262.0694. 
     Step 2. Synthesis of triketone 27 from 26. 
     A solution of 26 (11 g, 42 mmol) in EtOH (224 mL) and water (56 mL) was treated with zinc (90 g, 1.4 mol) and calcium chloride (3 g, 27 mmol) and heated to reflux for 16 h. The reaction was filtered (Celite) and the filtrate was concentrated at reduced pressure to give an aqueous residue which was extracted with EtOAc (100 mL). The organic layer was separated and washed with sat. EDTA (100 ml) and brine (100 mL), dried (MgSO 4 ), filtered, and concentrated at reduced pressure to give a yellow solid. Trituration with hexane gave the product as a yellow solid (7.1 g, 73%). mp 241-243° C.; CIMS (M+H) calc&#39;d for C 13 H 14 NO 3 : 232.0974, found: 232.0962. 
     Step 3. Synthesis of 28 from 27. 
     A solution of 27 (500 mg, 2.16 mmol) in CH2Cl2 (5 mL) was treated with Et3N (0.36 mL, 2.59 mmol) and stirred at 25° C. for 15 min. The reaction mixture was treated with acetyl chloride (0.18 mL, 2.38 mmol) and stirred at 25° C. for 1 h. The reaction mixture was quenched with 1 N HCl (20 mL) and extracted with EtOAc (20 mL). The organic layer was separated, dried (MgSO4), filtered, and concentrated at reduced pressure to give a brown residue. Trituration with hexane gave the product as a tan solid (484 mg, 82%). mp 241-243° C.; CIMS (M+H) calc&#39;d for C 15 H 16 NO 4 : 274.1079, found: 274.1093. 
     Step 4. Synthesis of 29 from 28. 
     A solution of 28 (240 mg, 0.88 mmol) in BuOH (5 mL) was treated with hydrazine hydrate (0.055 mL, 1.76 mmol) and p-TsOH (8.4 mg, 0.044 mmol). The reaction was heated to reflux and stirred for 4 h. The reaction was cooled to 25° C. and the solvent removed at reduced pressure. Recrystalization with i-propyl alcohol gave the product collected as an off-white solid (173 mg, 73%). mp &gt;250° C.; ESIMS (M+H) calc&#39;d for C 15 H 16 N 3 O 2 : 270.1242, found: 270.1258. 
     Example LXXXVII 
     Preparation of 3-(c-propyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using the c-propyl analog of 26 as the starting material. mp 220-221° C.; CIMS (M+H) calc&#39;d for C 15 H 14 N 3 O 2 : 268.1086, found: 268.1078. 
     Example LXXXVIII 
     Preparation of 3-(t-butyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using the t-butyl analog of 26 as the starting material. mp &gt;250° C.; CIMS (M+H) calc&#39;d for C 16 H 18 N 3 O 2 : 284.1399, found: 284.1395. 
     Example LXXXIX 
     Preparation of 3-(2-thienyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using the 2-thienyl analog of 26 as the starting material. mp 269° C.; CIMS (M+H) calc&#39;d for C 16 H 12 N 3 O 2 S: 310.0650, found: 310.0635. 
     Example XC 
     Preparation of 3-(3-methyl-2-thienyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using the 3-methyl-2-thienyl analog of 26 as the starting material. mp 275° C.; ESIMS (M+H) calc&#39;d for C 17 H 14 N 3 O 2 S: 324.0811, found: 324.0807. 
     Example XCI 
     Preparation of 3-(ethyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the ethyl analog of 15 as the starting materials. mp &gt;250° C.; CIMS (M+H) calc&#39;d for C 13 H 13 N 4 O 2 : 257.1039, found: 257.1033. 
     Example XCII 
     Preparation of 3-(n-propyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the n-propyl analog of 15 as the starting materials. mp 187-189° C.; CIMS (M+H) calc&#39;d for C 14 H 15 N 4 O 2 : 271.1195, found: 271.1187. 
     Example XCIII 
     Preparation of 3-(i-propyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the i-propyl analog of 15 as the starting materials. mp &gt;250° C.; CIMS (M+H) calc&#39;d for C 14 H 15 N 4 O 2 : 271.1195, found: 271.1196. 
     Example XCIV 
     Preparation of 3-(c-propyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the c-propyl analog of 15 as the starting materials. mp 252-253° C.; ESIMS (M-H) calc&#39;d for C 14 H 11 N 4 O 2 : 267.0881, found: 267.0884. 
     Example XCV 
     Preparation of 3-(c-hexyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the c-hexyl analog of 15 as the starting materials. mp 178-179° C.; ESIMS (M+H) calc&#39;d for C 17 H 19 N 4 O 2 : 311.1507, found: 311.1500. 
     Example XCVI 
     Preparation of 3-(2-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 2-thienyl analog of 15 as the starting materials. mp 214° C.; CIMS m+ calc&#39;d for C 15 H 10 N 4 O 2 S: 310.0517, found: 310.0524. 
     Example XCVII 
     Preparation of 3-(3-methyl-2-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 3-methyl-2-thienyl analog of 15 as the starting materials. mp 270° C.; ESIMS (M+H) calc&#39;d for C 16 H 13 N 4 O 2 S: 325.0759, found: 325.0744. 
     Example XCVIII 
     Preparation of 3-(5-methyl-2-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 5-methyl-2-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 16 H 13 N 4 O 2 S: 325.0759, found: 325.0761. 
     Example XCIX 
     Preparation of 3-(5-ethylcarboxyl-2-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 5-ethylcarboxyl-2-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 18 H 15 N 4 O 4 S: 383.0813, found: 383.0788. 
     Example C 
     Preparation of 3-(3-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 3-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 15 H 11 N 4 O 2 S: 311.0603, found: 311.0594. 
     Example CI 
     Preparation of 3-(5-chloro-3-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 5-chloro-3-thienyl analog of 15 as the starting materials. mp &gt;300° C.; ESIMS (M+H) calc&#39;d for C 15 H 10 N 4 O 2 SCl: 345.0209, found: 345.0213. 
     Example CII 
     Preparation of 3-(2,5-dimethyl-3-thienyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 2,5-dimethyl-3-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 17 H 15 N 4 O 2 S: 339.0916, found: 339.0905. 
     Example CIII 
     Preparation of 3-(2-furanyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 2-furanyl analog of 15 as the starting materials. mp 278° C.; ESIMS (M+H) calc&#39;d for C 15 H 11 N 4 O 3 : 295.0831, found: 295.0838. 
     Example CIV 
     Preparation of 3-(i-propyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the i-propyl analog of 15 as the starting materials. mp 231-233° C.; ESIMS (M+H) calc&#39;d for C 16 H 20 N 5 O 2 : 314.1616, found: 314.1599. 
     Example CV 
     Preparation of 3-(c-propyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the c-propyl analog of 15 as the starting materials. mp XXX ° C.; ESIMS (M+H) calc&#39;d for C 16 H 18 N 5 O 2 : 312.1460, found: 312.1487. 
     Example CVI 
     Preparation of 3-(c-hexyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the c-hexyl analog of 15 as the starting materials. mp 229-231° C.; ESIMS (M+H) calc&#39;d for C 19 H 24 N 5 O 2 : 354.1929, found: 354.1932. 
     Example CVII 
     Preparation of 3-(2-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the 2-thienyl analog of 15 as the starting materials. mp 279° C.; ESIMS (M+H) calc&#39;d for C 17 H 16 N 5 O 2 S: 354.1024, found: 354.1025. 
     Example CVIII 
     Preparation of 3-(5-methoxy-2-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,l-dimethylhydrazine and the 5-methoxy-2-thienyl analog of 15 as the starting materials. mp 280° C.; ESIMS (M+H) calc&#39;d for C 18 H 18 N 5 O 3 S: 384.1130, found: 384.1119. 
     Example CIX 
     Preparation of 3-(5-methyl-2-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the 5-methyl-2-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 18 H 18 N 5 O 2 S: 368.1181, found: 368.1171. 
     Example CX 
     Preparation of 3-(5-ethylcarboxyl-2-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 11-dimethylhydrazine and the 5-ethylcarboxyl-2-thienyl analog of 15 as the starting materials. mp 252° C.; ESIMS (M+H) calc&#39;d for C 20 H 20 N 5 O 4 S: 426.1236, found: 426.1251. 
     Example CXI 
     Preparation of 3-(3-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the 3-thienyl analog of 15 as the starting materials. mp 202° C.; ESIMS (M+H) calc&#39;d for C 17 H 16 N 5 O 2 S: 354.1025, found: 354.1031. 
     Example CXII 
     Preparation of 3-(1-methyl-3-pyrrolyl)-5-(carbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using ammonia and the 1-methyl-3-pyrrolyl analog of 15 as the starting materials. mp &gt;300° C.; ESIMS (M+H) calc&#39;d for C 16 H 14 N 5 O 2 : 308.1147, found: 308.1166. 
     Example CXIII 
     Preparation of 3-(2,5-dimethyl-3-thienyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the 2,5-dimethyl-3-thienyl analog of 15 as the starting materials. mp 252° C.; ESIMS (M+H) calc&#39;d for C 19 H 20 N 5 O 2 S: 382.1338, found: 382.1357. 
     Example CXIV 
     Preparation of 3-(2-furanyl)-5-(N,N-dimethylaminocarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1,1-dimethylhydrazine and the 2-furanyl analog of 15 as the starting materials. mp 202° C.; ESIMS (M+H) calc&#39;d for C 17 H 16 N 5 O 3 : 338.1253, found: 338.1248. 
     Example CXV 
     Preparation of 3-(i-propyl)-5-(4-carbamoylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using isonipecotamide and the i-propyl analog of 14 as the starting materials. mp 224-225° C.; ESIMS (M+H) calc&#39;d for C 21 H 26 N 5 O 3 : 396.2035, found: 396.2036. 
     Example CXVI 
     Preparation of 3-(c-hexyl)-5-(4-carbamoylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using isonipecotamide and the c-hexyl analog of 14 as the starting materials. mp 228-229° C.; ESIMS (M+H) calc&#39;d for C 24 H 30 N 5 O 3 : 436.2348, found: 436.2345. 
     Example CXVII 
     Preparation of 3-(ethyl)-5-(4-aminomethylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(aminomethyl)piperidine and the ethyl analog of 14 as the starting materials. mp 174-176° C.; ESIMS (M+H) calc&#39;d for C 20 H 26 N 5 O 2 : 368.2086, found: 368.2078. 
     Example CXVIII 
     Preparation of 3-(i-propyl)-5-(4-aminomethylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(aminomethyl)piperidine and the i-propyl analog of 14 as the starting materials. mp 218-220° C.; ESIMS (M+H) calc&#39;d for C 21 H 28 N 5 O 2 : 382.2242, found: 382.2227. 
     Example CXIX 
     Preparation of 3-(c-propyl)-5-(4-aminomethylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(aminomethyl)piperidine and the c-propyl analog of 14 as the starting materials. mp 138-140° C.; ESIMS (M+H) calc&#39;d for C 21 H 26 N 5 O 2 : 380.2086, found: 380.2079. 
     Example CXX 
     Preparation of 3-(c-hexyl)-5-(4-aminomethylpiperidinylacetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example XXIII using 4-(aminomethyl)piperidine and the c-hexyl analog of 14 as the starting materials. mp 196-198° C.; ESIMS (M+H) calc&#39;d for C 24 H 32 N 5 O 2 : 422.2555, found: 422.2540. 
     Example CXXI 
     Preparation of 3-(i-propyl)-5-(4-methylpiperazinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1-amino-4-methylpiperazine and the i-propyl analog of 15 as the starting materials. mp 231-233° C.; ESIMS (M+H) calc&#39;d for C 19 H 25 N 6 O 2 : 369.2038, found: 369.2039. 
     Example CXXII 
     Preparation of 3-(5-ethylcarboxyl-2-thienyl)-5-(4-methylpiperazinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1-amino-4-methylpiperazine and the 5-ethylcarboxyl-2-thienyl analog of 15 as the starting materials. mp 249° C.; ESIMS (M+H) calc&#39;d for C 23 H 25 N 6 O 4 S: 481.1657, found: 481.1642. 
     Example CXXIII 
     Preparation of 3-(5-carboxyl-2-thienyl)-5-(4-methylpiperazinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     A solution of CXXII (30 mg, 0.05 mmol) in 3:1 THF/water (2 mL) was treated with LiOH (23 mg, 0.5 mmol) and the reaction was stirred at 25° C. for 12 h and then heated to reflux for 1 h. The organic solvent was removed at reduced pressure and the residue was partioned between EtOAc (5 mL) and water (5 mL). The organic layer was separated and the aqueous phase was adjusted to pH=2 with 1 M HCl and re-extracted with EtOAc (5 mL). The combined organic layers were dried (Na2SO4), filtered and concentrated at reduced pressure to give a crude residue. Purification by reverse phase HPLC gave the product as a yellow solid (10.4 mg, 46%). mp 270° C.; ESIMS (M+H) calc&#39;d for C 21 H 21 N 6 O 4 S: 453.1344, found: 453.1353. 
     Example CXXIV 
     Preparation of 3-(2,5-dimethyl-3-thienyl)-5-(4-methylpiperazinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 1-amino-4-methylpiperazine and the 2,5-dimethyl-3-thienyl analog of 15 as the starting materials. mp 250° C.; ESIMS (M+H) calc&#39;d for C 22 H 25 N 6 O 2 S: 437.1760, found: 437.1771. 
     Example CXXV 
     Preparation of 3-(i-propyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the i-propyl analog of 15 as the starting materials. mp 256-258° C.; ESIMS (M−H) calc&#39;d for C 18 H 20 N 5 O 3 : 354.1566, found: 354.1543. 
     Example CXXVI 
     Preparation of 3-(N-methylcarbamoyl-4-piperidinyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the N-methylcarbamoyl-4-piperidinyl analog of 15 as the starting materials. mp 216-218° C.; ESIMS (M+H) calc&#39;d for C 22 H 27 N 6 O 5 : 455.2042, found: 455.2036. 
     Example CXXVII 
     Preparation of 3-(5-methyl-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the 5-methyl-2-thienyl analog of 15 as the starting materials. mp 261° C.; ESIMS (M+H) calc&#39;d for C 20 H 20 N 5 O 3 S: 410.1287, found: 410.1308. 
     Example CXXVIII 
     Preparation of 3-(5-chloro-3-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the 5-chloro-3-thienyl analog of 15 as the starting materials. mp 259° C.; ESIMS (M+H) calc&#39;d for C 19 H 17 N 5 O 3 SCl: 430.0741, found: 430.0757. 
     Example CXXIX 
     Preparation of 3-(2,5-dimethyl-3-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the 2,5-dimethyl-3-thienyl analog of 15 as the starting materials. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 21 H 22 N 5 O 3 S: 424.1443, found: 424.1431. 
     Example CXXX 
     Preparation of 3-(5-ethylcarboxyl-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI using 4-aminomorpholine and the 5-ethylcarboxyl-2-thienyl analog of 15 as the starting materials. mp 258° C.; ESIMS (M+H) calc&#39;d for C 22 H 22 N 5 O 5 S: 468.1341, found: 468.1331. 
     Example CXXXI 
     Preparation of 3-(5-carboxyl-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI (HYDROLYSIS OF PREVIOUS ESTER). mp 273° C.; ESIMS (M+H) calc&#39;d for C 20 H 18 N 5 O 5 S: 440.1028, found: 440.1026. 
     Example CXXXII 
     Preparation of 3-(5-benzylcarboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     A solution of benzylamine (0.01 mL, 0.09 mmol) in DMF (1 mL) was treated with acid CXXXI (40 mg, 0.09 mmol) and stirred at 25° C. The reaction was treated with TBTU (29 mg, 0.09 mmol) and stirred at 25° C. for 30 min. Triethylamine (0.01 mL, 0.09 mmol) was added and the reaction stirred at 25° C. for 12 h. After adding more TBTU (15 mg, 0.045 mmol) and triethylamine (0.01 mL, 0.09 mmol) the reaction was stirred at 25° C. for an additional 4 h. The reaction was diluted with EtOAc (10 mL) and water (10 mL) and the aqueous layer was extracted with EtOAc (5×10 mL). The combined organic layers were dried (Na2SO4), filtered, and the solvent removed at reduced pressure. Purification of the residue using reverse phase HPLC gave the product as a yellow solid (21 mg, 42%). mp 275° C.; ESIMS (M+H) calc&#39;d for C 27 H 25 N 5 O 4 S: 529.1659, found: 529.1682. 
     Example CXXXIII 
     Preparation of 3-(5-(4-methylpiperazinyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1-amino-4-methylpiperazine as the starting material. mp 190° C.; ESIMS (M+H) calc&#39;d for C 25 H 29 N 8 O 4 S: 537.2032, found: 537.2055. 
     Example CXXXIV 
     Preparation of 3-(5-(2-(1-methylpyrrolidinyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 2-(2-aminoethyl)-1-methylpyrrolidine as the starting material. mp 235° C.; ESIMS (M+H) calc&#39;d for C 27 H 32 N 7 O 4 S: 550.2236, found: 550.2229. 
     Example CXXXV 
     Preparation of 3-(5-(N,N-dimethylamino)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1,1-dimethylhydrazine as the starting material. mp 201° C.; ESIMS (M+H) calc&#39;d for C 22 H 24 N 7 O 4 S: 482.1610, found: 482.1588. 
     Example CXXXVI 
     Preparation of 3-(5-(2-(N,N-dimethylamino)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using N,N-dimethylethylenediamine as the starting material. mp 190° C.; ESIMS (M+H) calc&#39;d for C 24 H 28 N 7 O 4 S: 510.1923, found: 510.1922. 
     Example CXXXVII 
     Preparation of 3-(5-(2-(pyrrolidinyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1-(2-aminoethyl)pyrrolidine as the starting material. mp 224° C.; ESIMS (M+H) calc&#39;d for C 26 H 30 N 7 O 4 S: 536.2080, found: 536.2091. 
     Example CXXXVIII 
     Preparation of 3-(5-(2-(morpholinyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 4-(2-aminoethyl)morpholine as the starting material. mp 241° C.; ESIMS (M+H) calc&#39;d for C 26 H 30 N 7 O 5 S: 552.2029, found: 552.2043. 
     Example CXXXIX 
     Preparation of 3-(5-morpholinylcarboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 4-aminomorpholine as the starting material. mp 271° C.; ESIMS (M+H) calc&#39;d for C 24 H 26 N 7 O 5 S: 524.1716, found: 524.1719. 
     Example CXL 
     Preparation of 3-(5-(3-(pyrrolidonyl)propyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1-(3-aminopropyl)-2-pyrrolidinone as the starting material. mp 260° C.; ESIMS (M+H) calc&#39;d for C 27 H 30 N 7 O 5 S: 564.2029, found: 564.2031. 
     Example CXLI 
     Preparation of 3-(5-(2-(3-pyridyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 3-(2-aminoethyl)pyridine as the starting material. mp 203° C.; ESIMS (M+H) calc&#39;d for C 27 H 26 N 7 O 4 S: 544.1766, found: 544.1760. 
     Example CXLII 
     Preparation of 3-(5-(3-(imidazolyl)propyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1-(3-aminopropyl)imidazole as the starting material. mp 263° C.; ESIMS (M+H) calc&#39;d for C 26 H 27 N 8 O 4 S: 547.1875, found: 547.1872. 
     Example CXLIII 
     Preparation of 3-(5-(2-(2-pyridyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 2-(2-aminoethyl)pyridine as the starting material. mp &gt;280° C.; ESIMS (M+H) calc&#39;d for C 27 H 26 N 7 O 4 S: 544.1767, found: 544.1778. 
     Example CXLIV 
     Preparation of 3-(5-((2-pyridyl)methyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 2-(aminomethyl)pyridine as the starting material. mp 239° C.; ESIMS (M+H) calc&#39;d for C 26 H 24 N 7 O 4 S: 530.1610, found: 530.1603. 
     Example CXLV 
     Preparation of 3-(5-(2-(piperidinyl)ethyl)carboxamido-2-thienyl)-5-(morpholinylcarbamoyl)aminoindeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CXXXII using 1-(2-aminoethyl)piperidine as the starting material. mp 228° C.; ESIMS (M+H) calc&#39;d for C 27 H 32 N 7 O 4 S: 550.2236, found: 550.2236. 
     Example CXLVI 
     Preparation of 3-(4-(trifluoromethyl)phenyl)-5-(acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example LXXXVI employing 1-(4-(trifluoromethyl)phenyl)-4,4,4-trifluoro-1,3-butanedione as the starting material. mp &gt;300° C.; ESI − -MS m/e calc&#39;d for C 19 H 11 N 3 O 2 : 370.0804, found: 370.0809. 
     Example CXLVII 
     Preparation of 3-(4-(4-t-butoxycarbonyl-1-piperazinyl)phenyl)-5-(((4-morpholinylamino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     Step 1. Synthesis of 30. 
     A solution of 4-piperazinoacetophenone (24.8 g, 121 mmol) and di-tert-butyl dicarbonate (27.8 g, 128 mmol) in 480 mL of tetrahydrofuran was refluxed for 16 h. After cooling to room temperature the solution was concentrated under vacuum. The resulting solids were washed with hexane and dried under vacuum to afford 29.4 g (80%) of the product as an off-white solid. NMR (CDCl 3 ) δ7.89 (d, 2 H, J=9 Hz), 6.87 (d, 2 H, J=9 Hz), 3.59 (m, 4 H), 3.33 (m, 4 H), 2.53 (s, 3 H), 1.49 (s, 9 H). 
     Step 2. Synthesis of 31 from 30. 
     To a solution of 30 (11.35 g, 37 mmol) and ethyl trifluoroacetate (5.40 mL, 45 mmol) in 50 mL of tetrahydrofuran at 25° C. was added dropwise over 15 min. 21% sodium ethoxide in ethanol (16.8 mL, 45 mmol), and the resulting solution then was stirred at 25° C. for 14 h. The reaction mixture was diluted with water, adjusted to pH 5 with conc. hydrochloric acid, and extracted with ethyl acetate. The combined extracts was washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The resulting solid was washed with diethyl ether and dried to furnish 12.1 g (81%) of the product as an orange solid. NMR (CDCl 3 ) δ7.87 (d, 2 H, J=9 Hz), 6.87 (d, 2 H, J=9 Hz), 6.45 (s, 1 H), 3.60 (m, 4 H), 3.41 (m, 4 H), 1.48 (s, 9 H). 
     Step 3. Synthesis of CXLVII from 31. 
     Prepared in a similar fashion as described for examples LXXVI and XLII employing 31 and 4-aminomorpholine as starting materials. mp 242° C.; ESI-MS m/e calc&#39;d for C 30 H 36 N 7 O 5 574.2778, found: 574.2762. 
     Example CXLVIII 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-(((4-morpholinylamino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     A solution of CXLVII (0.58 g, 1.0 mmol) in 20 mL of trifluoroacetic acid was stirred at 25° C. for 2 h. The reaction mixture was concentrated under vacuum, and the residue was recrystallized from ethanol to provide 0.53 g (89%) of the yellow product as its TFA-salt. mp 263° C.; ESI-MS m/e calc&#39;d for C 25 H 28 N 7 O 3 : 474.2254, found: 474.2280. 
     Example CXLIX 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((aminocarbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples XLII and CXLVIII employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII and ammonia as the starting materials. mp 257° C.; ESI-MS m/e calc&#39;d for C 21 H 21 N 6 O 2 : 389.1726, found: 389.1724. 
     Example CL 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((hydrazinocarbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for examples XLII and CXLVIII employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII and hydrazine as the starting materials. mp 257° C.; ESI-MS m/e calc&#39;d for C 21 H 22 N 7 O 2 : 404.1835, found: 404.1834. 
     Example CLI 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((dimethylamino)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII as the starting material. Chloroacetylation and treatment with dimethylamine in a similar fashion as described for examples II and XXIII, followed by treatment with hydrazine and removal of the t-butoxycarbonyl group in a similar fashion as described for examples I and CXLVIII, afforded the example compound. mp 243° C.; ESI-MS m/e calc&#39;d for C 24 H 27 N 6 O 2 : 431.2196, found: 431.2198. 
     Example CLII 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((4-morpholinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII as the starting material. Chloroacetylation and treatment with morpholine in a similar fashion as described for examples II and XXIII, followed by treatment with hydrazine and removal of the t-butoxycarbonyl group in a similar fashion as described for examples I and CXLVIII, afforded the example compound. mp 259° C.; ESI-MS m/e calc&#39;d for C 26 H 29 N 6 O 3 : 473.2301, found: 473.2302. 
     Example CLIII 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((4-methyl-1-piperazinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII as the starting material. Chloroacetylation and treatment with 1-methylpiperazine in a similar fashion as described for examples II and XXIII, followed by treatment with hydrazine and removal of the t-butoxycarbonyl group in a similar fashion as described for examples I and CXLVIII, afforded the example compound. ESI-MS m/e calc&#39;d for C 27 H 32 N 7 O 2 : 486.2618, found: 486.2608. 
     Example CLIV 
     Preparation of 3-(4-(1-piperazinyl)phenyl)-5-((4-amino methyl-1-piperidinyl)acetamido)indeno[1,2-c]pyrazol-4-one 
     Prepared employing 2-(4-(4-t-butoxycarbonyl-1-piperazinyl)benzoyl)-4-amino-1,3-indanedione obtained in example CXLVII as the starting material. Chloroacetylation and treatment with 4-(aminomethyl)piperidine in a similar fashion as described for examples II and XXIII, followed by treatment with hydrazine and removal of the t-butoxycarbonyl group in a similar fashion as described for examples I and CXLVIII, afforded the example compound. mp 239° C.; ESI-MS m/e calc&#39;d for C 28 H 34 N 7 O 2 : 500.2774, found: 500.2772. 
     Example CLV 
     Preparation of 3-(4-(4-methyl-1-piperazinyl)phenyl)-5-(((4-morpholinylamino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     To a solution of CXLVIII (0.17 g, 0.29 mmol) in 10 mL of methanol and 2 mL of water at 25° C. was added sequentially 37% aqueous formaldehyde (0.45 g, 5.8 mmol), sodium cyanoborohydride (0.18 g, 2.9 mmol), and 4 drops of acetic acid. The resulting solution was stirred at 25° C. for 16 h. The mixture was diluted with water. It then was made acidic (˜pH 1) with conc. hydrochloric acid and stirred for 10 min. The solution next was made basic (˜pH 13) with 50% aqueous sodium hydroxide and finally adjusted to pH 10 with 1 N hydrochloric acid. The mixture was extracted with 4:1 chloroform/isopropanol. The combined extracts were washed with water and brine, dried over anhydrous sodium sulfate, and filtered. To the filtrate was added excess trifluoroacetic acid, and the solution was concentrated under vacuum. The residue was recrystallized from isopropanol to furnish 0.16 g (92%) of the yellow product as its TFA-salt. mp 245° C.; ESI-MS m/e calc&#39;d for C 26 H 30 N 7 O 3 : 488.2410, found: 488.2420. 
     Example CLVI 
     Preparation of 3-(4-(4-ethyl-1-piperazinyl)phenyl)-5-(((4-morpholinylamino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLV employing CXLVIII and acetaldehyde as the starting materials. mp 245° C.; ESI-MS m/e calc&#39;d for C 27 H 32 N 7 O 3 : 502.2567, found: 502.2555. 
     Example CLVII 
     Preparation of 3-(4-(4-isopropyl-1-piperazinyl)phenyl)-5-(((4-morpholinylamino)carbonyl)amino)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLV employing CXLVIII and acetone as the starting materials. mp 253° C.; ESI-MS m/e calc&#39;d for C 28 H 34 N 7 O 3 : 516.2723, found: 516.2726. 
     Example CLVIII 
     Preparation of 3-(4-methoxyphenyl)-5-(2-benzoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Step 1. Synthesis of 31 from 13.                          
     A suspension of aniline 31 (0.5 g, 1.7 mmol) in dioxane (10 mL) was treated with triethylamine (0.48 mL, 3.4 mmol) in one portion at room temperature. Then 2-(trimethylsilyl) ethyloxy chloride (SEMCl) (0.48 mL, 2.6 mmol) was added in one portion and the mixture heated to reflux for 2 h. The reaction was cooled, diluted with EtOAc (20 mL) washed with water (10 mL), dried (MgSO4) and the solvent removed at reduced pressure. The residue was taken up in benzene (3 mL), applied to a plug of silica gel (10 g) and eluted with EtOAc/Hexane (1:3) until all the yellow color was washed from the silica gel plug. The solvent was evaporated and the residue taken on to the next step. This material was dissolved in dioxane (10 mL) and treated with K2CO3 (0.36 g, 2.6 mmol) in one portion. Then phenylchloroformate (0.27 mL, 2.23 mmol) was added in one portion and the reaction heated to 50 C. for 2 h. The reaction was cooled and the solvent removed at reduced pressure. The residue was recrystalized from EtOH to give a yellow solid (0.4 g, 43%). mp °C.; CIMS m/e calculated for C 30 H 32 N 3 O 5 Si: 542.2111, found: 542.2101; 
     Step 2. Synthesis of Ex. CLVIII from 31. 
     Compound 31 (0.015 g, 0.03 mmol) in DMSO (0.2 mL) was treated with phenylcarbazte (0.008 g, 0.06 mmol) in one portion and heated to 80 C. for 30 minutes. The solvent was removed at reduced pressure heating to 65 C. The residue was disolved in EtOH (0.5 mL) and treated with 4N HCl/dioxane (0.4 mL). The mixture was heated to 80 C. for 20 minutes and then cooled. The desired product was filtered and air dried (0.008 g, 62%). mp &gt;300° C.; CIMS m/e calculated for C 26 H 27 N 4 O 4 : 459.2032, found: 459.1999; 
     Example CLIX 
     Preparation of 3-(4-methoxyphenyl)-5-(2-isonicotinoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 4-pyridylcarbazate as the starting material. mp 248° C.; CIMS m/e calculated for C 24 H 19 N 6 O 4 : 455.1468, found: 455.1400; 
     Example CLX 
     Preparation of 3-(4-methoxyphenyl)-5-(2-nictinoylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 3-pyridylcarbazate as the starting material. mp 227° C.; CIMS m/e calc&#39;d for C 24 H 19 N 6 O 4 : 455.1468, found: 455.1487; 
     Example CLXI 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(3,4-dihydroxy benzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 3,4-dihydroxyphenyl carbazate as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 25 H 20 N 5 O 6 : 486.1414, found: 486.1497; 
     Example CLXII 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(4-hydroxy benzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 4-hydroxyphenyl carbazate as the starting material. mp 283° C.; CIMS m/e calc&#39;d for C 25 H 20 N 5 O 5 : 470.1464, found: 470.1544; 
     Example CLXIII 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(3-aminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 3-aminophenyl carbazate as the starting material. mp 250° C.; CIMS m/e calc&#39;d for C 25 H 21 N 6 O 4 : 469.1624, found: 469.1513; 
     Example CLXIV 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(4-aminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 4-aminophenyl carbazate as the starting material. mp 247° C.; CIMS m/e calc&#39;d for C 25 H 21 N 6 O 4 : 469.1624, found: 469.1528; 
     Example CLXV 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(2-aminobenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 2-aminophenyl carbazate as the starting material. mp 257° C.; CIMS m/e calc&#39;d for C 25 H 21 N 6 O 4 : 469.1624, found: 469.1548; 
     Example CLXVI 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(4-N,N-dimethylamino benzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 4-N,N-dimethylaminophenyl carbazate as the starting material. mp 259° C.; CIMS m/e calc&#39;d for C 27 H 25 N 6 O 4 : 497.1937, found: 497.1876; 
     Example CLXVII 
     Preparation of 3-(4-methoxyphenyl)-5-(2-phenethylacetyl hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using benzyl carbazate as the starting material. mp 269° C.; CIMS m/e calc&#39;d for C 26 H 22 N 5 O 4 : 468.1672, found: 468.1313; 
     Example CLXVIII 
     Preparation of 3-(4-methoxyphenyl)-5-(2-(2-hydroxybenzoyl)hydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using 2-hydroxyphenyl carbazate as the starting material. mp 280° C.; CIMS m/e calc&#39;d for C 25 H 20 N 5 O 5 : 470.1464, found: 470.1419; 
     Example CLXIX 
     Preparation of 3-(4-methoxyphenyl)-5-(2-methoxycarbonylhydrazinecarboxamido)indeno[1,2-c]pyrazol-4-one 
     Prepared in a similar fashion as described for example CLVIII using carbazic acid methyl ester as the starting material. mp &gt;300° C.; CIMS m/e calc&#39;d for C 20 H 28 N 5 O 5 : 408.1308, found: 408.1397; 
     EXAMPLE CLXX 
     Preparation of Intermediate CLXX 
     The preparation of intermediate CLXX, (N-[2-(4-Methoxy-benzoyl)-1,3-dioxo-indan-4-yl]-acetamide) is described in Nugiel, D. A.; Etzkorn, A. M.; Vidwans, A.; Benfield, P. A.; Boisclair, M.; Burton, C. R.; Cox, S.; Czerniak, P. M.; Doleniak, D.; Seitz, S. P. J. Med. Chem. 2001, 44, 1334-1336 which is herein incorporated by reference in it&#39;s entirety as though set forth in full. 
     EXAMPLE CLXXI 
     Preparation of Intermediate CLXXI 
     Synthesis of 4-Amino-2-(4-methoxy-benzoyl)-indan-1,3-dione: The compound prepared in example 1 (2.0 g, 5.93 mmol) is dissolved in 20% HCl in methanol (50 mL). This solution is stirred at reflux for a period of 3 h. It is then allowed to cool to room temperature and stirred overnight. The product is filtered off, washed with ethanol (20 mL) and air dried to give the product as a yellow solid (1.5 g, 85.7%). mp 268-269° C.;  1 H NMR (DMSOd 6 ) δ8.17 (d, J=8.8 Hz, 2H), 7.49 (t, 1H), 7.12 (d, J=8.7 Hz, 2H), 6.98 (m, 2H), 3.88 (s, 1H). 
     EXAMPLE CLXXII 
     Preparation of Intermediate CLXXII 
     Synthesis of [2-(4-Methoxybenzoyl)-1,3-dioxo-indan-4-yl]-carbamic acid phenyl ester: The product prepared in Example CLXXI (1.5 g, 5.08 mmol) is dissolved in acetone (40 mL) and treated with sodium carbonate (1.26 g, 15.24 mmol) and phenyl chloroformate (1.19 g, 7.62 mmol). The suspension is stirred at 50° C. for 3 h. The reaction mixture is diluted with water (120 mL), and extracted with ethyl acetate (2×100 mL). The organic layer is separated, washed with brine (50 mL), dried (Na 2 SO 4 ) and the solvent removed at reduced pressure to give a gummy orange residue. Cold ethyl ether (100 mL) is added to this residue to give a precipitate. The precipitate is collected and washed with ethyl ether (2×10 mL) to give desired product as a yellow solid (1.65 g. 78%). mp 256-258° C.;  1 H NMR (DMSOd 6 ) δ10.83 (s, 1H), 8.08 (d, J=8.0 Hz, 1H), 7.57 (d, J=2.9 Hz, 2H), 7.54 (m, 3H), 7.28 (m, 3H), 7.09 (t, 1H), 6.89 (d, J=10.8 Hz, 2H), 3.81 (s, 3H). 
     EXAMPLE CLXXIII 
     Preparation of 1-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-yl-urea 
     
       
                 
         
             
             
         
      
     
     The product prepared in Example CLXXII (0.03 g, 0.072 mmol) in anhydrous DMSO (2 mL) is treated with 4-aminomorpholine (0.0084 g, 0.082 mmol) and 4-dimethylaminopyridine (0.005 g, 0.04 mmol) and heated to 80° C. for 3 h. The solvent is removed under reduced pressure and the residue triturated with ethanol to give a dark solid. The solid is collected and washed with ethanol (5 mL) to give a tricarbonyl urea (0.03 g, 100%). The tricarbonyl urea intermediate (0.03 g, 0.078 mmol) is treated with hydrazine hydrate (0.1 mL, 3.21 mmol) and p-toluenesulfonic acid monohydrate (0.01 g, 0.05 mmol) in refluxing ethanol (4 mL) for a period of 3 h. The reaction mixture is cooled to room temperature, the solid collected, washed with cold ethanol (2×2 mL), and air dried to give the product as a yellowish solid (0.012 g, 41.3%). mp 290-291° C.;  1 H NMR (DMSO-d 6 ) δ8.27 (d, J=6.8 Hz, 2H), 8.16 (d, J=8.8 Hz, 2H), 7.42 (m, 1H), 7.12 (m, 3H), 3.81 (s, 3H), 2.90 (s, 4H), 2.70 (s, 4H), HRMS calcd. for C 22 H 22 N 5 O 4  (M+H + ) 420.1672; found 420.1688; 
     EXAMPLE CLXXIV 
     Preparation of [3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea 
     
       
                 
         
             
             
         
      
     
     The product prepared in Example CLXXII (0.03 g, 0.072 mmol) in anhydrous DMSO (2 mL) is treated with excess ammonium hydroxide solution and 4-dimethylaminopyridine (0.005 g, 0.04 mmol) and is heated to 80° C. for 3 h. The solvent is removed under reduced pressure and the residue triturated with ethanol to give a dark solid. The solid is collected and washed with ethanol (5 mL) to give urea (0.03 g, 100%). The tricarbonyl urea intermediate (0.03 g, 0.078 mmol) is treated with hydrazine hydrate (0.1 mL, 3.21 mmol) and p-toluenesulfonic acid monohydrate (0.01 g, 0.05 mmol) in refluxing ethanol (4 mL) for a period of 3 h. The reaction mixture is cooled to room temperature, the solid collected, washed with cold ethanol (2×2 mL), and air dried to give the product as a yellowish solid (0.018 g, 62.4%). mp 267-269° C.;  1 H NMR (DMSO-d 6 ) δ9.35 (s, 1H), 8.22 (m, 3H), 7.38 (m, 1H), 7.10 (d, J=8.8 Hz, 2H), 7.02 (d, J=7 Hz, 1H), 3.81 (s, 3H); HRMS calcd. for C 18 H 15 N 4 O 3  (M+H + ) 335.1144; found 335.1162; 
     EXAMPLE CLXXV 
     Preparation of 1-(2-amino-cyclohexyl)-3-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-urea 
     
       
                 
         
             
             
         
      
     
     The product prepared in Example CLXXII (0.03 g, 0.072 mmol) in anhydrous DMSO (2 mL) is treated with 1,2-diaminocyclohexane (0.01 g, 0.082 mmol) and 4-dimethylaminopyridine (0.005 g, 0.04 mmol) and heated to 80° C. for 3 h. The solvent is removed under reduced pressure and the residue triturated with ethanol to give a dark solid. The solid is collected and washed with ethanol (5 mL) to give a tricarbonyl urea (0.03 g, 100%). The tricarbonyl urea intermediate (0.03 g, 0.078 mmol) is treated with hydrazine hydrate (0.1 mL, 3.21 mmol) and p-toluenesulfonic acid monohydrate (0.01 g, 0.05 mmol) in refluxing ethanol (4 mL) for a period of 3 h. The reaction mixture is cooled to room temperature, the solid collected, washed with cold ethanol (2×2 mL), and air dried to give the product as a yellowish solid (0.01 g, 30.6%).  1 HNMR (DMSO-d 6 ) δ9.56 (s, 1H), 8.27 (d, 1H), 8.19 (d, 2H), 7.41 (t, 1H), 7.10 (m, 3H), 4.10 (s, 1H), 3.81 (s, 3H), 3.23 (s, 1H), 1.63 (m, 5H), 1.40 (m, 3H). 
     EXAMPLE CLXXVI 
     Preparation of 5-Amino-3-(4-methoxyphenyl)-2-phenyl-2H-indeno-[1,2-c]pyrazol-4-one: 
     
       
                 
         
             
             
         
      
     
     A suspension of N-[3-(4-Methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide (as produced according to Nugiel, D. A.; Etzkorn, A. M.; Vidwans, A.; Benfield, P. A.; Boisclair, M.; Burton, C. R.; Cox, S.; Czerniak, P. M.; Doleniak, D.; Seitz, S. P. J. Med. Chem. 2001, 44, 1334-1336) (1.0 g, 3.0 mmol) in MeOH (10 mL) was treated with concentrated HCl (1 mL) and heated to reflux. After stirring the mixture for 2 h the reaction was cooled and the product was collected by filtration and obtained as a greenish solid (0.7 g, 81%). mp 273° C.; NMR (DMSO-d 6 ) δ13.6 (bs, 1 H), 8.3 (d, J=8.4 Hz, 1 H), 8.1 (d, J=8.8 Hz, 2 H), 7.5 (t, J=7.7 Hz 1 H), 7.2 (d, J=7.0 Hz, 1 H), 7.1 (d, J=8.8 Hz, 2 H), 3.8 (s, 3 H); HRMS m/e calc&#39;d for C 17 H 14 N 3 O 2  (M+H): 292.1086, found: 292.1080. 
     EXAMPLE CLXXVII 
     Preparation of 2-Chloro-N-[3-(4-methoxyphenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide 
     
       
                 
         
             
             
         
      
     
     A suspension of the product prepared in Example CLXXVI (0.2 g, 0.7 mmol) in dioxane (10 mL) was treated with aqueous saturated NaHCO 3  (3 mL) and chloroacetyl chloride (3 mL, 0.21 mmol). The reaction was heated to 50° C. and stirred for 2 h. The reaction is then cooled, poured into water (20 mL), extracted with EtOAc (100 mL), the organic layer separated, dried (MgSO 4 ) and the solvent removed at reduced pressure. The residue is recrystallized from EtOH to give the product as a yellow solid (0.09 g, 35%). mp &gt;300° C.; NMR (DMSO-d 6 ) δ13.6 (bs, 1 H), 11.3 (s, 1 H), 8.3 (d, J=8.4 Hz, 1 H), 8.1 (d, J=8.8 Hz, 2 H), 7.5 (t, J=7.7 Hz 1 H), 7.2 (d, J=7.0 Hz, 1 H), 7.1 (d, J=8.8 Hz, 2 H), 4.5 (s, 2 H), 3.8 (s, 3 H); HRMS m/e calc&#39;d for C 19 H 15 N 3 O 3 Cl (M+H): 368.0802, found: 368.0818. 
     EXAMPLE CLXXVIII 
     Preparation of 2-(4-aminomethyl-piperidin-1-yl)-N-[3-(4-methoxy-phenyl)-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide 
     
       
                 
         
             
             
         
      
     
     A suspension of product prepared according to Example CLXXVII (0.015 g, 0.04 mmol) in EtOH (1 mL) is treated with 4-aminomethylpiperdine (0.75 mL), placed in a sealed tube and heated to 80° C. for 3 h. The reaction is cooled and the solvent removed at reduced pressure. The residue is recrystallized from EtOH to give the product as a yellow solid (0.009 g, 62%). mp &gt;300° C.; NMR (DMSO-d 6 ) δ13.6 (bs, 1 H), 11.3 (s, 1 H), 8.35 (d, J=8.4 Hz, 1 H), 8.1 (d, J=8.8 Hz, 2 H), 7.5 (t, J=7.7 Hz 1 H), 7.2 (d, J=7.0 Hz, 1 H), 7.1 (d, J=8.8 Hz, 2 H), 3.8 (s, 3 H), 3.2 (bs, 2 H), 2.9(bs, 2 H), 2.5 (d, J=8.0 Hz, 2 H), 2.2 (t, J=8.0 Hz, 2 H), 1.6 (m, 5 H); HRMS m/e calc&#39;d for C 25 H 28 N 5 O 3  (M+H): 446.2192, found: 446.2169; Anal. (C 25 H 27 N 5 O 3 ) C, H, N. 
     EXAMPLE CLXXIX 
     Preparation of 2-(4-Methoxybenzoyl)-3-methoxycarbonylamino-indan-1,3-dione 
     
       
                 
         
             
             
         
      
     
     A solution of 3-methoxycarbonylamino-phthalic acid dimethyl ester (1 g, 4.8 mmol) and 4-methoxyacetophenone (0.72 g, 4.8 mmol) in dry DMF (3 mL) was heated to 90° C. Sodium hydride (0.21 g, 60% suspension in oil, 5.2 mmol) is added in one portion and the exothermic reaction turns deep red. After 20 min, the reaction is cooled to room temperature, diluted with water (25 mL) extracted with EtOAc (10 mL) and the aqueous phase separated. The aqueous phase is acidified to pH 2 with 2N HCl and the crude product collected. Recrystallization with ethanol gives the desired product as a yellow solid (0.4 g, 30%). ESIMS 352 (M−H, 100%). 
     EXAMPLE CLXXX 
     Preparation of 3-(4-Methoxyphenyl)-5-methoxycarbonylamino-2H-indeno-[1,2-c]pyrazol-4-one 
     
       
                 
         
             
             
         
      
     
     A solution of 2-(4-methoxybenzoyl)-3-methoxycarbonylamino-indan-1,3-dione (0.2 g, 0.6 mmol) in EtOH (5 mL) is treated with hydrazine hydrate (0.1 mL, 1.8 mmol) and p-TsOH (3 mg). The reaction is heated to reflux and stirred for 2 h. The reaction is cooled to room temperature and the product crystallized from the reaction mixture. The product is collected by filtration as a yellow solid (0.1 g, 50%). mp &gt;300° C.; HRMS m/e calc&#39;d for C 19 H 16 N 3 O 4  (M+H): 350.1141, found: 350.1168. 
     Utility 
     Inhibition of Kinase/Cyclin Complex Enzymatic Activity 
     Several of the compounds disclosed in this invention were assayed for their inhibitory activity against cdk4/D1 and cdk2/E kinase complexes. Briefly, the in vitro assays employ cell lysates from insect cells expressing either of the kinases and subsequently their corresponding regulatory units. The cdk2/cyclinE is purified from insect cells expressing His-tagged cdk2 and cyclin E. The cdk/cyclin lysate is combined in a microtitre-type plate along with a kinase compatible buffer,  32 P-labeled ATP at a concentration of 50 mM, a GST-Rb fusion protein and the test compound at varying concentrations. The kinase reaction is allowed to proceeded with the radiolabled ATP, then effectively stopped by the addition of a large excess of EDTA and unlabeled ATP. The GST-Rb labeled protein is sequestered on a GSH-Sepharose bead suspension, washed, resuspended in scintillant, and the  32 P activity detected in a scintillation counter. The compound concentration which inhibits 50% of the kinase activity was calculated for each compound. A compound was considered active if its IC 50  was found to be less than 1 μM. 
     Inhibition of HCT 116 Cancer Cell Proliferation 
     To test the cellular activity of several compounds disclosed in this invention, we examined the effect of these compounds on cultured HCT116 cells and determined their effect on cell-cycle progression by the calorimetric cytotoxcity test using sulforhodamine B (Skehan et al. J. Natl. Cancer Inst. 82:1107-12, 1990). Briefly, HCT116 cells are cultured in the presence of test compounds at increasing concentrations. At selected time points, groups of cells are fixed with trichloroacetic acid and stained with sulforhodamine B (SRB). Unbound dye was removed by washing and protein-bound dye was extracted for determination of optical density. A compound was considered active if its IC 50  was found to be less than 10 μM. 
     
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Example 
                   
                   
                 mass 
                 mp 
               
               
                 # 
                 R 1   
                 R 2   
                 (M + H) 
                 (° C.) 
               
               
                   
               
             
          
           
               
                 I 
                 Methyl 
                 4-MeOC 6 H 4   
                 334 
                 268 
               
               
                 II 
                 ClCH 2   
                 4-MeOC 6 H 4   
                 382 
                 274 
               
               
                 III 
                 Cyclopropyl 
                 4-MeOC 6 H 4   
                 360 
                 289 
               
               
                 IV 
                 Isopropyl 
                 4-MeOC 6 H 4   
                 362 
                 288 
               
               
                 V 
                 Ethyl 
                 4-MeOC 6 H 4   
                 348 
                 287 
               
               
                 VI 
                 Cyclopentyl 
                 4-MeOC 6 H 4   
                 388 
                 267 
               
               
                 VII 
                 Cyclobutyl 
                 4-MeOC 6 H 4   
                 374 
                 297 
               
               
                 VIII 
                 Benzyl 
                 4-MeOC 6 H 4   
                 410 
                 280 
               
               
                 IX 
                 n-propyl 
                 4-MeOC 6 H 4   
                 362 
                 282 
               
               
                 X 
                 4-ClC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 444 
                 238 
               
               
                 XI 
                 3-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 440 
                 &gt;300 
               
               
                 XII 
                 4-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 440 
                 280 
               
               
                 XIII 
                 3,4-diMeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 470 
                 &gt;300 
               
               
                 XIV 
                 2,5-diMeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 470 
                 226 
               
               
                 XV 
                 Methyl 
                 2-MeOC 6 H 4   
                 334 
                 276 
               
               
                 XVI 
                 Methyl 
                 3,4-diMeOC 6 H 4   
                 364 
                 &gt;300 
               
               
                 XVII 
                 3,4-(OCH 2 O)C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 454 
                 297 
               
               
                 XVIII 
                 3-thiophenylCH 2   
                 4-MeOC 6 H 4   
                 416 
                 293 
               
               
                 XIX 
                 2-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 440 
                 255 
               
               
                 XX 
                 3,4-diClOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 479 
                 299 
               
               
                 XXI 
                 2,4-diClOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 479 
                 286 
               
               
                 XXII 
                 2-ClC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 444 
                 300 
               
               
                 XXIII 
                 H 2 NCH 2   
                 4-MeOC 6 H 4   
                 349 
                 &gt;300 
               
               
                 XXIV 
                 HOCH 2 CH 2 NHCH 2   
                 4-MeOC 6 H 4   
                 393 
                 243 
               
               
                 XXV 
                 Me 2 NCH 2   
                 4-MeOC 6 H 4   
                 377 
                 279 
               
               
                 XXVI 
                 piperazinylCH 2   
                 4-MeOC 6 H 4   
                 418 
                 277 
               
               
                 XXVII 
                 4-Me-piperazinylCH 2   
                 4-MeOC 6 H 4   
                 432 
                 &gt;300 
               
               
                 XXVIII 
                 4-HOCH 2 CH 2 - 
                 4-MeOC 6 H 4   
                 462 
                 &gt;300 
               
               
                   
                 piperazinylCH 2   
               
               
                 XXIX 
                 piperidinylCH 2   
                 4-MeOC 6 H 4   
                 417 
                 291 
               
               
                 XXX 
                 4-NH 2 CH 2 - 
                 4-MeOC 6 H 4   
                 446 
                 &gt;300 
               
               
                   
                 piperidinylCH 2   
               
               
                 XXXI 
                 CH 3 CH 2 NHCH 2   
                 4-MeOC 6 H 4   
                 377 
                 250 
               
               
                 XXXII 
                 ThiomorpholinylCH 2   
                 4-MeOC 6 H 4   
                 435 
                 298 
               
               
                 XXXIII 
                 morpholinylCH 2   
                 4-MeOC 6 H 4   
                 419 
                 295 
               
               
                 XXXIV 
                 pyrrolidinylCH 2   
                 4-MeOC 6 H 4   
                 403 
                 279 
               
               
                 XXXV 
                 4-pyridylCH 2 NHCH 2   
                 4-MeOC 6 H 4   
                 440 
                 &gt;300 
               
               
                 XXXVI 
                 4-CH 3 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 467 
                 268 
               
               
                 XXXVII 
                 4-CH 3 OCONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 483 
                 257 
               
               
                 XXXVIII 
                 4-NH 2 CH 2 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 482 
                 228 
               
               
                 XXXIX 
                 4-Me 2 NCH 2 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 510 
                 &gt;300 
               
               
                 XL 
                 4-N 3 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 451 
                 &gt;300 
               
               
                 XLI 
                 4-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
                 425 
                 283 
               
               
                 XLII 
                 C 6 H 5 NH 
                 4-MeOC 6 H 4   
                 411 
                 &gt;300 
               
               
                 XLIII 
                 CH 3 CH 2 CH 2 NH 
                 4-MeOC 6 H 4   
                 377 
                 252 
               
               
                 XLIV 
                 4-NH 2 C 6 H 4 CH 2 NH 
                 4-MeOC 6 H 4   
                 440 
                 &gt;300 
               
               
                 XLV 
                 4-pyridylCH 2 NH 
                 4-MeOC 6 H 4   
                 426 
                 &gt;300 
               
               
                 XLVI 
                 Methyl 
                 4-HOC 6 H 4   
                 320 
                 &gt;300 
               
               
                 XLVII 
                 H 
                 4-MeOC 6 H 4   
                 320 
                 280 
               
               
                 XLVIII 
                 Methyl 
                 3-pyridyl 
                 305 
                 &gt;300 
               
               
                 XLIX 
                 Methyl 
                 4-pyridyl 
                 305 
                 &gt;300 
               
               
                 L 
                 H 
                 4-pyridyl 
                 291 
                 &gt;300 
               
               
                 LI 
                 Methyl 
                 C 6 H 5   
                 305 
                 &gt;300 
               
               
                 LII 
                 Methyl 
                 4-MeSC 6 H 4   
                 351 
                 283 
               
               
                 LIII 
                 Methyl 
                 4-MeSO 2 C 6 H 4   
                 383 
                 &gt;300 
               
               
                 LVI 
                 Methyl 
                 4-Me 2 NC 6 H 4   
                 348 
                 &gt;300 
               
               
                 LV 
                 morpholinylCH 2   
                 4-Me 2 NC 6 H 4   
                 432 
                 &gt;300 
               
               
                 LVI 
                 Me 2 NCH 2   
                 4-Me 2 NC 6 H 4   
                 390 
                 &gt;300 
               
               
                 LVII 
                 Methyl 
                 4-(piperdinyl)C 6 H 4   
                 388 
                 291 
               
               
                 LVIII 
                 Methyl 
                 4-(morpholinyl)C 6 H 4   
                 389 
                 &gt;300 
               
               
                 LIX 
                 Methyl 
                 4-CH 3 CH 2 OC 6 H 4   
                 349 
                 288 
               
               
                 LX 
                 Methyl 
                 4-CH 3 CH 2 CH 2 CH 2 C 6 H 4   
                 361 
                 259 
               
               
                 LXI 
                 Methyl 
                 4-CH 3 CH 2 C 6 H 4   
                 332 
                 294 
               
               
                 LXII 
                 Methyl 
                 4-CH 3 CH 2 CH 2 C 6 H 4   
                 347 
                 269 
               
               
                 LXIII 
                 NH 2   
                 4-MeOC 6 H 4   
                 335 
                 &gt;300 
               
               
                 LXIV 
                 Me2NNH 
                 4-MeOC 6 H 4   
                 378 
                 &gt;300 
               
               
                 LXV 
                 MeNH 
                 4-MeOC 6 H 4   
                 349 
                 &gt;300 
               
               
                 LXVI 
                 MorpholinylNH 
                 4-MeOC 6 H 4   
                 420 
                 &gt;300 
               
               
                 LXVII 
                 cis-1,2- 
                 4-MeOC 6 H 4   
                 432 
                 &gt;300 
               
               
                   
                 diaminocyclohexanyl 
               
               
                 LXVIII 
                 4-methyl- 
                 4-MeOC 6 H 4   
                 433 
                 &gt;300 
               
               
                   
                 piperazinylNH 
               
               
                 LXVIX 
                 4-uridomethyl- 
                 4-MeOC 6 H 4   
                 489 
                 &gt;300 
               
               
                   
                 piperadinylCH 2   
               
               
                 LXX 
                 4-(2-pyridyl)- 
                 4-MeOC 6 H 4   
                 495 
                 &gt;300 
               
               
                   
                 piperazinyl CH 2   
               
               
                 LXXI 
                 4-(aminoethyl)- 
                 4-MeOC 6 H 4   
                 461 
                 &gt;300 
               
               
                   
                 piperazinyl CH 2   
               
               
                 LXXII 
                 4-amidopiperidinylCH 2   
                 4-MeOC 6 H 4   
                 460 
                 &gt;300 
               
               
                 LXXIII 
                 4-hydroxy- 
                 4-MeOC 6 H 4   
                 433 
                 &gt;300 
               
               
                   
                 piperidinylCH 2   
               
               
                 LXXIV 
                 4-hydroxy- 
                 4-MeOC 6 H 4   
                 447 
                 &gt;300 
               
               
                   
                 methylpiperidinylCH 2   
               
               
                 LXXV 
                 4-amidopiperazinylCH 2   
                 4-MeOC 6 H 4   
                 493 
                 &gt;300 
               
               
                 LXXVI 
                 4-dimethyl- 
                 4-MeOC 6 H 4   
                 492 
                 &gt;300 
               
               
                   
                 aminopiperadinylCH 2   
               
               
                 LXXVII 
                 4-aminopiperadinylCH 2   
                 4-MeOC 6 H 4   
                 464 
                 &gt;300 
               
               
                 LXXVIII 
                 4-Me-piperazinylCH 2   
                 4-Me 2 NC 6 H 4   
                 445 
                 &gt;300 
               
               
                 LXXIX 
                 4-NH 2 CH 2 - 
                 4-Me 2 NC 6 H 4   
                 459 
                 NA 
               
               
                   
                 piperidinylCH 2   
               
               
                 LXXX 
                 4-OH-piperidinylCH 2   
                 4-Me 2 NC 6 H 4   
                 446 
                 267 
               
               
                 LXXXI 
                 morpholinylCH 2   
                 4-(morpholinyl)C 6 H 4   
                 474 
                 258 
               
               
                 LXXXII 
                 4-Me-piperazinylCH 2   
                 4-(morpholinyl)C 6 H 4   
                 487 
                 258 
               
               
                 LXXXIII 
                 4-OH-piperidinylCH 2   
                 4-(morpholinyl)C 6 H 4   
                 488 
                 245 
               
               
                 LXXXIV 
                 4-NH 2 CH 2 - 
                 4-(morpholinyl)C 6 H 4   
                 501 
                 240 
               
               
                   
                 piperidinylCH 2   
               
               
                 LXXXV 
                 4-Me-piperazinylNH 
                 4-Me 2 NC 6 H 4   
                 446 
                 &gt;300 
               
               
                 LXXXVI 
                 Methyl 
                 i-propyl 
                 270 
                 &gt;250 
               
               
                 LXXXVII 
                 Methyl 
                 c-propyl 
                 268 
                 220 
               
               
                 LXXXVIII 
                 Methyl 
                 t-butyl 
                 284 
                 &gt;250 
               
               
                 LXXXIX 
                 Methyl 
                 2-thienyl 
                 310 
                 269 
               
               
                 XC 
                 Methyl 
                 3-Me-2-thienyl 
                 324 
                 275 
               
               
                 XCI 
                 NH 2   
                 Ethyl 
                 257 
                 &gt;250 
               
               
                 XCII 
                 NH 2   
                 n-propyl 
                 271 
                 187 
               
               
                 XCIII 
                 NH 2   
                 i-propyl 
                 271 
                 &gt;250 
               
               
                 XCIV 
                 NH 2   
                 c-propyl 
                 267 
                 252 
               
               
                   
                   
                   
                 (M − H) 
               
               
                 XCV 
                 NH 2   
                 c-hexyl 
                 311 
                 178 
               
               
                 XCVI 
                 NH 2   
                 2-thienyl 
                 310 
                 214 
               
               
                   
                   
                   
                 (M+) 
               
               
                 XCVII 
                 NH 2   
                 3-Me-2-thienyl 
                 325 
                 270 
               
               
                 XCVIII 
                 NH 2   
                 5-Me-2-thienyl 
                 325 
                 &gt;280 
               
               
                 XCIX 
                 NH 2   
                 5-CO 2 Et-2-thienyl 
                 383 
                 &gt;280 
               
               
                 C 
                 NH 2   
                 3-thienyl 
                 311 
                 &gt;280 
               
               
                 CI 
                 NH 2   
                 5-Cl-3-thienyl 
                 345 
                 &gt;300 
               
               
                 CII 
                 NH 2   
                 2,5-diMe-3-thienyl 
                 339 
                 &gt;280 
               
               
                 CIII 
                 NH 2   
                 2-furanyl 
                 295 
                 278 
               
               
                 CIV 
                 Me 2 NNH 
                 i-propyl 
                 314 
                 231 
               
               
                 CV 
                 Me 2 NNH 
                 c-propyl 
                 312 
               
               
                 CVI 
                 Me 2 NNH 
                 c-hexyl 
                 354 
                 229 
               
               
                 CVII 
                 Me 2 NNH 
                 2-thienyl 
                 354 
                 279 
               
               
                 CVIII 
                 Me 2 NNH 
                 5-MeO-2-thienyl 
                 384 
                 280 
               
               
                 CIX 
                 Me 2 NNH 
                 5-Me-2-thienyl 
                 368 
                 &gt;280 
               
               
                 CX 
                 Me 2 NNH 
                 5-CO 2 Et-2-thienyl 
                 426 
                 252 
               
               
                 CXI 
                 Me 2 NNH 
                 3-thienyl 
                 354 
                 202 
               
               
                 CXII 
                 NH 2   
                 1-methyl-3- 
                 308 
                 &gt;300 
               
               
                   
                   
                 pyrrolyl 
               
               
                 CXIII 
                 Me 2 NNH 
                 2,5-diMe-3-thienyl 
                 382 
                 252 
               
               
                 CXIV 
                 Me 2 NNH 
                 2-furanyl 
                 338 
                 202 
               
               
                 CXV 
                 4-NH 2 CO- 
                 i-propyl 
                 396 
                 224 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXVI 
                 4-NH 2 CO- 
                 c-hexyl 
                 436 
                 228 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXVII 
                 4-NH 2 CH 2 - 
                 ethyl 
                 368 
                 174 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXVIII 
                 4-NH 2 CH 2 - 
                 1-propyl 
                 382 
                 218 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXVIX 
                 4-NH 2 CH 2 - 
                 c-propyl 
                 380 
                 138 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXX 
                 4-NH 2 CH 2 - 
                 c-hexyl 
                 422 
                 196 
               
               
                   
                 piperidinylCH 2   
               
               
                 CXXI 
                 4-CH 3 -piperazinylNH 
                 i-propyl 
                 369 
                 231 
               
               
                 CXXII 
                 4-CH 3 -piperazinylNH 
                 5-CO 2 Et-2-thienyl 
                 481 
                 249 
               
               
                 CXXIII 
                 4-CH 3 -piperazinylNH 
                 5-CO 2 H-2-thienyl 
                 453 
                 270 
               
               
                 CXXIV 
                 4-CH 3 -piperazinylNH 
                 2,5-diMe-3-thienyl 
                 437 
                 250 
               
               
                 CXXV 
                 MorpholinylNH 
                 i-propyl 
                 354 
                 256 
               
               
                   
                   
                   
                 (M − H) 
               
               
                 CXXVI 
                 MorpholinylNH 
                 4-CO 2 Me- 
                 455 
                 216 
               
               
                   
                   
                 piperidinyl 
               
               
                 CXXVII 
                 MorpholinylNH 
                 5-Me-2-thienyl 
                 410 
                 261 
               
               
                 CXXVIII 
                 MorpholinylNH 
                 5-Cl-3-thienyl 
                 430 
                 259 
               
               
                 CXXIX 
                 MorpholinylNH 
                 2,5-diMe-3-thienyl 
                 424 
                 &gt;280 
               
               
                 CXXX 
                 MorpholinylNH 
                 5-CO 2 Et-2-thienyl 
                 468 
                 258 
               
               
                 CXXXI 
                 MorpholinylNH 
                 5-CO 2 H-2-thienyl 
                 440 
                 273 
               
               
                 CXXXII 
                 MorpholinylNH 
                 5-CONHBn-2-thienyl 
                 529 
                 275 
               
               
                 CXXXIII 
                 MorpholinylNH 
                 5-CONH(4-Me- 
                 537 
                 190 
               
               
                   
                   
                 piperazinyl)-2- 
               
               
                   
                   
                 thienyl 
               
               
                 CXXXIV 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (1-Me- 
                 550 
                 235 
               
               
                   
                   
                 2-pyrrolidinyl)-2-thienyl 
               
               
                 CXXXV 
                 MorpholinylNH 
                 5-CONHNMe 2 -2-thienyl 
                 482 
                 201 
               
               
                 CXXXVI 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 NMe 2 - 
                 510 
                 190 
               
               
                   
                   
                 2-thienyl 
               
               
                 CXXXVII 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (1- 
                 536 
                 224 
               
               
                   
                   
                 pyrrolidinyl)-2-thienyl 
               
               
                 CXXXVIII 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (1- 
                 552 
                 241 
               
               
                   
                   
                 morpholinyl)-2-thienyl 
               
               
                 CXXXIX 
                 MorpholinylNH 
                 5-CONHmorpholinyl-2-thienyl 
                 524 
                 271 
               
               
                 CXL 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 CH 2 (1- 
                 564 
                 260 
               
               
                   
                   
                 pyrrolidonyl)-2-thienyl 
               
               
                 CXLI 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (3- 
                 544 
                 203 
               
               
                   
                   
                 pyridyl)-2-thienyl 
               
               
                 CXLII 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 CH 2 (1- 
                 547 
                 263 
               
               
                   
                   
                 imidazolyl)-2-thienyl 
               
               
                 CXLIII 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (2- 
                 544 
                 &gt;280 
               
               
                   
                   
                 pyridyl)-2-thienyl 
               
               
                 CXLIV 
                 MorpholinylNH 
                 5-CONHCH 2 (3- 
                 530 
                 239 
               
               
                   
                   
                 pyridyl)-2-thienyl 
               
               
                 CXLV 
                 MorpholinylNH 
                 5-CONHCH 2 CH 2 (1- 
                 550 
                 228 
               
               
                   
                   
                 piperidinyl)-2-thienyl 
               
               
                 CXLVI 
                 Methyl 
                 4-CF 3 C 6 H 4   
                 370 
                 &gt;300 
               
               
                   
                   
                   
                 (M − H) 
               
               
                 CXLVII 
                 MorpholinylNH 
                 4-(4-Boc- 
                 574 
                 242 
               
               
                   
                   
                 piperazinyl)C 6 H 4   
               
               
                 CXLVIII 
                 MorpholinylNH 
                 4-(piperazinyl)C 6 H 4   
                 474 
                 263 
               
               
                 CXLIX 
                 NH 2   
                 4-(piperazinyl)C 6 H 4   
                 389 
                 257 
               
               
                 CL 
                 NH 2 NH 
                 4-(piperazinyl)C 6 H 4   
                 404 
                 257 
               
               
                 CLI 
                 Me 2 NCH 2   
                 4-(piperazinyl)C 6 H 4   
                 431 
                 243 
               
               
                 CLII 
                 morpholinylCH 2   
                 4-(piperazinyl)C 6 H 4   
                 473 
                 259 
               
               
                 CLIII 
                 4-Me-piperazinylCH 2   
                 4-(piperazinyl)C 6 H 4   
                 486 
                 NA 
               
               
                 CLIV 
                 4-NH 2 CH 2 - 
                 4-(piperazinyl)C 6 H 4   
                 500 
                 239 
               
               
                   
                 piperidinylCH 2   
               
               
                 CLV 
                 MorpholinylNH 
                 4-(4-Me- 
                 488 
                 245 
               
               
                   
                   
                 piperazinyl)C 6 H 4   
               
               
                 CLVI 
                 MorpholinylNH 
                 4-(4-Et- 
                 502 
                 245 
               
               
                   
                   
                 piperazinyl)C 6 H 4   
               
               
                 CLVII 
                 MorpholinylNH 
                 4-(4-i-Pr- 
                 516 
                 253 
               
               
                   
                   
                 piperazinyl)C 6 H 4   
               
               
                 CLVIII 
                 C 6 H 5 C(O)NHNH 
                 4-MeOC 6 H 4   
                 459 
                 &gt;300 
               
               
                 CLIX 
                 4-pyridylC(O)NHNH 
                 4-MeOC 6 H 4   
                 455 
                 248 
               
               
                 CLX 
                 3-pyridylC(O)NHNH 
                 4-MeOC 6 H 4   
                 455 
                 227 
               
               
                 CLXI 
                 3,4-dihydroxy- 
                 4-MeOC 6 H 4   
                 486 
                 &gt;300 
               
               
                   
                 C 6 H 3 C(O)NHNH 
               
               
                 CLXII 
                 4-hydroxy- 
                 4-MeOC 6 H 4   
                 470 
                 283 
               
               
                   
                 C 6 H 4 C(O)NHNH 
               
               
                 CLXIII 
                 3-amino-C 6 H 4 C(O)NHNH 
                 4-MeOC 6 H 4   
                 469 
                 250 
               
               
                 CLXIV 
                 4-amino-C 6 H 4 C(O)NHNH 
                 4-MeOC 6 H 4   
                 469 
                 247 
               
               
                 CLXV 
                 2-amino-C 6 H 4 C(O)NHNH 
                 4-MeOC 6 H 4   
                 469 
                 257 
               
               
                 CLXVI 
                 4-N,N-dimethylamino- 
                 4-MeOC 6 H 4   
                 497 
                 259 
               
               
                   
                 C 6 H 4 C(O)NHNH 
               
               
                 CLXVII 
                 C 6 H 5 CH 2 C(O)NHNH 
                 4-MeOC 6 H 4   
                 468 
                 269 
               
               
                 CLXVIII 
                 2-hydroxy- 
                 4-MeOC 6 H 4   
                 470 
                 280 
               
               
                   
                 C 6 H 4 C(O)NHNH 
               
               
                 CLXIX 
                 MeOC(O)NHNH 
                 4-MeOC 6 H 4   
                 408 
                 &gt;300 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Example 
                   
                   
               
               
                 Number 
                 R 1   
                 R 2   
               
               
                   
               
             
          
           
               
                 100 
                 2-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 101 
                 2-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 102 
                 2-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 103 
                 2-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 104 
                 2-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 105 
                 2-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 106 
                 2-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 107 
                 2-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 108 
                 2-pyridylmethyl 
                 4-pyridyl 
               
               
                 109 
                 2-pyridylmethyl 
                 3-pyridyl 
               
               
                 110 
                 2-pyridylmethyl 
                 2-pyridyl 
               
               
                 111 
                 2-pyridylmethyl 
                 2-thiazolyl 
               
               
                 112 
                 2-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 113 
                 2-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 114 
                 2-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 115 
                 2-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 116 
                 2-pyridylmethyl 
                 2-imidazolyl 
               
               
                 117 
                 2-pyridylmethyl 
                 2-oxazolyl 
               
               
                 118 
                 2-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 119 
                 2-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 120 
                 2-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 121 
                 2-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 122 
                 2-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 123 
                 2-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 124 
                 3-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 125 
                 3-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 126 
                 3-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 127 
                 3-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 128 
                 3-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 129 
                 3-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 130 
                 3-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 131 
                 3-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 132 
                 3-pyridylmethyl 
                 4-pyridyl 
               
               
                 133 
                 3-pyridylmethyl 
                 3-pyridyl 
               
               
                 134 
                 3-pyridylmethyl 
                 2-pyridyl 
               
               
                 135 
                 3-pyridylmethyl 
                 2-thiazolyl 
               
               
                 136 
                 3-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 137 
                 3-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 138 
                 3-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 139 
                 3-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 140 
                 3-pyridylmethyl 
                 2-imidazolyl 
               
               
                 141 
                 3-pyridylmethyl 
                 2-oxazolyl 
               
               
                 142 
                 3-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 143 
                 3-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 144 
                 3-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 145 
                 3-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 146 
                 3-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 147 
                 3-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 148 
                 4-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 149 
                 4-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 150 
                 4-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 151 
                 4-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 152 
                 4-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 153 
                 4-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 154 
                 4-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 155 
                 4-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 156 
                 4-pyridylmethyl 
                 4-pyridyl 
               
               
                 157 
                 4-pyridylmethyl 
                 3-pyridyl 
               
               
                 158 
                 4-pyridylmethyl 
                 2-pyridyl 
               
               
                 159 
                 4-pyridylmethyl 
                 2-thiazolyl 
               
               
                 160 
                 4-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 161 
                 4-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 162 
                 4-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 163 
                 4-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 164 
                 4-pyridylmethyl 
                 2-imidazolyl 
               
               
                 165 
                 4-pyridylmethyl 
                 2-oxazolyl 
               
               
                 166 
                 4-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 167 
                 4-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 168 
                 4-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 169 
                 4-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 170 
                 4-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 171 
                 4-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 172 
                 2-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 173 
                 2-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 174 
                 2-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 175 
                 2-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 176 
                 2-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 177 
                 2-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 178 
                 2-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 179 
                 2-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 180 
                 2-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 181 
                 2-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 182 
                 2-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 183 
                 2-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 184 
                 2-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 185 
                 2-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 186 
                 2-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 187 
                 2-NH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 188 
                 2-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 189 
                 2-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 190 
                 2-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 191 
                 2-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 192 
                 2-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 193 
                 2-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 194 
                 2-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 195 
                 2-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 196 
                 3-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 197 
                 3-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 198 
                 3-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 199 
                 3-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 200 
                 3-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 201 
                 3-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 202 
                 3-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 203 
                 3-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 204 
                 3-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 205 
                 3-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 206 
                 3-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 207 
                 3-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 208 
                 3-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 209 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 210 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 211 
                 3-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 212 
                 3-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 213 
                 3-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 214 
                 3-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 215 
                 3-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 216 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 217 
                 3-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 218 
                 3-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 219 
                 4-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 220 
                 4-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 221 
                 4-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 222 
                 4-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 223 
                 4-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 224 
                 4-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 225 
                 4-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 226 
                 4-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 227 
                 4-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 228 
                 4-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 229 
                 4-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 230 
                 4-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 231 
                 4-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 232 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 233 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 234 
                 4-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 235 
                 4-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 236 
                 4-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 237 
                 4-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 238 
                 4-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 239 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 240 
                 4-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 241 
                 4-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 242 
                 2-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 243 
                 2-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 244 
                 2-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 245 
                 2-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 246 
                 2-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 247 
                 2-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 248 
                 2-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 249 
                 2-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 250 
                 2-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 251 
                 2-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 252 
                 2-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 253 
                 2-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 254 
                 2-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 255 
                 2-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 256 
                 2-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 257 
                 2-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 258 
                 2-MeOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 259 
                 2-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 260 
                 2-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 261 
                 2-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 262 
                 2-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 263 
                 2-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 264 
                 2-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 265 
                 3-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 266 
                 3-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 267 
                 3-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 268 
                 3-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 269 
                 3-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 270 
                 3-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 271 
                 3-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 272 
                 3-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 273 
                 3-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 274 
                 3-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 275 
                 3-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 276 
                 3-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 277 
                 3-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 278 
                 3-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 279 
                 3-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 280 
                 3-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 281 
                 3-MeOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 282 
                 3-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 283 
                 3-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 284 
                 3-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 285 
                 3-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 286 
                 3-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 287 
                 3-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 288 
                 4-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 289 
                 4-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 290 
                 4-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 291 
                 4-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 292 
                 4-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 293 
                 4-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 294 
                 4-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 295 
                 4-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 296 
                 4-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 297 
                 4-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 298 
                 4-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 299 
                 4-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 300 
                 4-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 301 
                 4-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 302 
                 4-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 303 
                 4-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 304 
                 4-MeOC 6 H 4CH   2   
                 2-oxazolyl 
               
               
                 305 
                 4-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 306 
                 4-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 307 
                 4-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 308 
                 4-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 309 
                 4-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 310 
                 4-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 311 
                 2-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 312 
                 2-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 313 
                 2-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 314 
                 2-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 315 
                 2-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 316 
                 2-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 317 
                 2-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 318 
                 2-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 319 
                 2-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 320 
                 2-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 321 
                 2-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 322 
                 2-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 323 
                 2-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 324 
                 2-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 325 
                 2-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 326 
                 2-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 327 
                 2-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 328 
                 2-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 329 
                 2-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 330 
                 2-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 331 
                 2-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 332 
                 2-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 333 
                 2-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 334 
                 2-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 335 
                 3-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 336 
                 3-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 337 
                 3-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 338 
                 3-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 339 
                 3-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 340 
                 3-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 341 
                 3-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 342 
                 3-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 343 
                 3-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 344 
                 3-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 345 
                 3-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 346 
                 3-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 347 
                 3-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 348 
                 3-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 349 
                 3-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 350 
                 3-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 351 
                 3-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 352 
                 3-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 353 
                 3-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 354 
                 3-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 355 
                 3-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 356 
                 3-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 357 
                 3-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 358 
                 3-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 359 
                 4-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 360 
                 4-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 361 
                 4-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 362 
                 4-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 363 
                 4-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 364 
                 4-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 365 
                 4-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 366 
                 4-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 367 
                 4-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 368 
                 4-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 369 
                 4-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 370 
                 4-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 371 
                 4-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 372 
                 4-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 373 
                 4-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 374 
                 4-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 375 
                 4-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 376 
                 4-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 377 
                 4-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 378 
                 4-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 379 
                 4-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 380 
                 4-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 381 
                 4-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 382 
                 4-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 383 
                 4-ClC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 384 
                 4-ClC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 385 
                 4-ClC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 386 
                 4-ClC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 387 
                 4-ClC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 388 
                 4-ClC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 389 
                 4-ClC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 390 
                 4-ClC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 391 
                 4-ClC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 392 
                 4-ClC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 393 
                 4-ClC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 394 
                 4-ClC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 395 
                 4-ClC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 396 
                 4-ClC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 397 
                 4-ClC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 398 
                 4-ClC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 399 
                 4-ClC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 400 
                 4-ClC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 401 
                 4-ClC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 402 
                 4-ClC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 403 
                 4-ClC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 404 
                 4-ClC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 405 
                 4-ClC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 406 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 407 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 408 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 409 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 410 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 411 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 412 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 413 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 414 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 415 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 416 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 417 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 418 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 419 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 420 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 421 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 422 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 423 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 424 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 425 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 426 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 427 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 428 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 429 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 430 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 431 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 432 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 433 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 434 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 435 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 436 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 437 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 438 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 439 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 440 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 441 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 442 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 443 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 444 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 445 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 446 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 447 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 448 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 449 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 450 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 451 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 452 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 453 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 454 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 455 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 456 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 457 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 458 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 459 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 460 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 461 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 462 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 463 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 464 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 465 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 466 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 467 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 468 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 469 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 470 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 471 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 472 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 473 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 474 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 475 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 476 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 477 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 478 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 479 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 480 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 481 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 482 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 483 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 484 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 485 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 486 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 487 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 488 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 489 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 490 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 491 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 492 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 493 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 494 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 495 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 496 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 497 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 498 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 499 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 500 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 501 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 502 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 503 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 504 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 505 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 506 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 507 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 508 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 509 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 510 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 511 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 512 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 513 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 514 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 515 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 516 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 517 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 518 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 519 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 520 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 521 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 522 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 523 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 524 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 525 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 526 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 527 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 528 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 529 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 530 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 531 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 532 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 533 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 534 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 535 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 536 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 537 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 538 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 539 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 540 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 541 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 542 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 543 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 545 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 546 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 547 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 548 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 549 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 550 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 551 
                 H 
                 3-MeOC 6 H 4   
               
               
                 552 
                 H 
                 4-NH 2 C 6 H 4   
               
               
                 553 
                 H 
                 3-NH 2 C 6 H 4   
               
               
                 554 
                 H 
                 2-NH 2 C 6 H 4   
               
               
                 555 
                 H 
                 4-Me 2 NC 6 H 4   
               
               
                 556 
                 H 
                 3-Me 2 NC 6 H 4   
               
               
                 557 
                 H 
                 2-Me 2 NC 6 H 4   
               
               
                 558 
                 H 
                 3-pyridyl 
               
               
                 559 
                 H 
                 2-pyridyl 
               
               
                 560 
                 H 
                 2-thiazolyl 
               
               
                 561 
                 H 
                 2-pyrazolyl 
               
               
                 562 
                 H 
                 5-isoquinolyl 
               
               
                 563 
                 H 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 564 
                 H 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 565 
                 H 
                 2-imidazolyl 
               
               
                 566 
                 H 
                 2-oxazolyl 
               
               
                 567 
                 H 
                 4-isoxazolyl 
               
               
                 568 
                 H 
                 4-HOC 6 H 4   
               
               
                 569 
                 H 
                 3-HOC 6 H 4   
               
               
                 570 
                 H 
                 3,4-diHOC 6 H 4   
               
               
                 571 
                 H 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 572 
                 H 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 573 
                 Me 
                 3-MeOC 6 H 4   
               
               
                 574 
                 Me 
                 4-NH 2 C 6 H 4   
               
               
                 575 
                 Me 
                 3-NH 2 C 6 H 4   
               
               
                 576 
                 Me 
                 2-NH 2 C 6 H 4   
               
               
                 577 
                 Me 
                 4-Me 2 NC 6 H 4   
               
               
                 578 
                 Me 
                 3-Me 2 NC 6 H 4   
               
               
                 579 
                 Me 
                 2-Me 2 NC 6 H 4   
               
               
                 580 
                 Me 
                 3-pyridyl 
               
               
                 581 
                 Me 
                 2-pyridyl 
               
               
                 582 
                 Me 
                 2-thiazolyl 
               
               
                 583 
                 Me 
                 2-pyrazolyl 
               
               
                 584 
                 Me 
                 5-isoquinolyl 
               
               
                 585 
                 Me 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 586 
                 Me 
                 2-imidazolyl 
               
               
                 587 
                 Me 
                 2-oxazolyl 
               
               
                 588 
                 Me 
                 4-isoxazolyl 
               
               
                 589 
                 Me 
                 3-HOC 6 H 4   
               
               
                 590 
                 Me 
                 3,4-diHOC 6 H 4   
               
               
                 591 
                 Me 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 592 
                 Me 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 593 
                 Et 
                 3-MeOC 6 H 4   
               
               
                 594 
                 Et 
                 4-NH 2 C 6 H 4   
               
               
                 595 
                 Et 
                 3-NH 2 C 6 H 4   
               
               
                 596 
                 Et 
                 2-NH 2 C 6 H 4   
               
               
                 597 
                 Et 
                 4-Me 2 NC 6 H 4   
               
               
                 598 
                 Et 
                 3-Me 2 NC 6 H 4   
               
               
                 599 
                 Et 
                 2-Me 2 NC 6 H 4   
               
               
                 600 
                 Et 
                 4-pyridyl 
               
               
                 601 
                 Et 
                 3-pyridyl 
               
               
                 602 
                 Et 
                 2-pyridyl 
               
               
                 603 
                 Et 
                 2-thiazolyl 
               
               
                 604 
                 Et 
                 2-pyrazolyl 
               
               
                 605 
                 Et 
                 5-isoquinolyl 
               
               
                 606 
                 Et 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 607 
                 Et 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 608 
                 Et 
                 2-imidazolyl 
               
               
                 609 
                 Et 
                 2-oxazolyl 
               
               
                 610 
                 Et 
                 4-isoxazolyl 
               
               
                 611 
                 Et 
                 4-HOC 6 H 4   
               
               
                 612 
                 Et 
                 3-HOC 6 H 4   
               
               
                 613 
                 Et 
                 3,4-diHOC 6 H 4   
               
               
                 614 
                 Et 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 615 
                 Et 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 616 
                 Me 2 NCH 2   
                 3-MeOC 6 H 4   
               
               
                 617 
                 Me 2 NCH 2   
                 4-NH 2 C 6 H 4   
               
               
                 618 
                 Me 2 NCH 2   
                 3-NH 2 C 6 H 4   
               
               
                 619 
                 Me 2 NCH 2   
                 2-NH 2 C 6 H 4   
               
               
                 620 
                 Me 2 NCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 621 
                 Me 2 NCH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 622 
                 Me 2 NCH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 623 
                 Me 2 NCH 2   
                 4-pyridyl 
               
               
                 624 
                 Me 2 NCH 2   
                 3-pyridyl 
               
               
                 625 
                 Me 2 NCH 2   
                 2-pyridyl 
               
               
                 626 
                 Me 2 NCH 2   
                 2-thiazolyl 
               
               
                 627 
                 Me 2 NCH 2   
                 2-pyrazolyl 
               
               
                 628 
                 Me 2 NCH 2   
                 5-isoquinolyl 
               
               
                 629 
                 Me 2 NCH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 630 
                 Me 2 NCH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 631 
                 Me 2 NCH 2   
                 2-imidazolyl 
               
               
                 632 
                 Me 2 NCH 2   
                 2-oxazolyl 
               
               
                 633 
                 Me 2 NCH 2   
                 4-isoxazolyl 
               
               
                 634 
                 Me 2 NCH 2   
                 4-HOC 6 H 4   
               
               
                 635 
                 Me 2 NCH 2   
                 3-HOC 6 H 4   
               
               
                 636 
                 Me 2 NCH 2   
                 3,4-diHOC 6 H 4   
               
               
                 637 
                 Me 2 NCH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 638 
                 Me 2 NCH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 639 
                 EtNHCH 2   
                 3-MeOC 6 H 4   
               
               
                 640 
                 EtNHCH 2   
                 4-NH 2 C 6 H 4   
               
               
                 641 
                 EtNHCH 2   
                 3-NH 2 C 6 H 4   
               
               
                 642 
                 EtNHCH 2   
                 2-NH 2 C 6 H 4   
               
               
                 643 
                 EtNHCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 644 
                 EtNHCH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 645 
                 EtNHCH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 646 
                 EtNHCH 2   
                 4-pyridyl 
               
               
                 647 
                 EtNHCH 2   
                 3-pyridyl 
               
               
                 648 
                 EtNHCH 2   
                 2-pyridyl 
               
               
                 649 
                 EtNHCH 2   
                 2-thiazolyl 
               
               
                 650 
                 EtNHCH 2   
                 2-pyrazolyl 
               
               
                 651 
                 EtNHCH 2   
                 5-isoquinolyl 
               
               
                 652 
                 EtNHCH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 653 
                 EtNHCH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 654 
                 EtNHCH 2   
                 2-imidazolyl 
               
               
                 655 
                 EtNHCH 2   
                 2-oxazolyl 
               
               
                 656 
                 EtNHCH 2   
                 4-isoxazolyl 
               
               
                 657 
                 EtNHCH 2   
                 4-HOC 6 H 4   
               
               
                 658 
                 EtNHCH 2   
                 3-HOC 6 H 4   
               
               
                 659 
                 EtNHCH 2   
                 3,4-diHOC 6 H 4   
               
               
                 660 
                 EtNHCH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 661 
                 EtNHCH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 662 
                 HOCH 2 CH 2 NHCH 2   
                 3-MeOC 6 H 4   
               
               
                 663 
                 HOCH 2 CH 2 NHCH 2   
                 4-NH 2 C 6 H 4   
               
               
                 664 
                 HOCH 2 CH 2 NHCH 2   
                 3-NH 2 C 6 H 4   
               
               
                 665 
                 HOCH 2 CH 2 NHCH 2   
                 2-NH 2 C 6 H 4   
               
               
                 666 
                 HOCH 2 CH 2 NHCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 667 
                 HOCH 2 CH 2 NHCH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 668 
                 HOCH 2 CH 2 NHCH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 669 
                 HOCH 2 CH 2 NHCH 2   
                 4-pyridyl 
               
               
                 670 
                 HOCH 2 CH 2 NHCH 2   
                 3-pyridyl 
               
               
                 671 
                 HOCH 2 CH 2 NHCH 2   
                 2-pyridyl 
               
               
                 672 
                 HOCH 2 CH 2 NHCH 2   
                 2-thiazolyl 
               
               
                 673 
                 HOCH 2 CH 2 NHCH 2   
                 2-pyrazolyl 
               
               
                 674 
                 HOCH 2 CH 2 NHCH 2   
                 5-isoquinolyl 
               
               
                 675 
                 HOCH 2 CH 2 NHCH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 676 
                 HOCH 2 CH 2 NHCH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 677 
                 HOCH 2 CH 2 NHCH 2   
                 2-imidazolyl 
               
               
                 678 
                 HOCH 2 CH 2 NHCH 2   
                 2-oxazolyl 
               
               
                 679 
                 HOCH 2 CH 2 NHCH 2   
                 4-isoxazolyl 
               
               
                 680 
                 HOCH 2 CH 2 NHCH 2   
                 4-HOC 6 H 4   
               
               
                 681 
                 HOCH 2 CH 2 NHCH 2   
                 3-HOC 6 H 4   
               
               
                 682 
                 HOCH 2 CH 2 NHCH 2   
                 3,4-diHOC 6 H 4   
               
               
                 683 
                 HOCH 2 CH 2 NHCH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 684 
                 HOCH 2 CH 2 NHCH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 685 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-MeOC 6 H 4   
               
               
                 686 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-MeOC 6 H 4   
               
               
                 687 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-NH 2 C 6 H 4   
               
               
                 688 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-NH 2 C 6 H 4   
               
               
                 689 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-NH 2 C 6 H 4   
               
               
                 690 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 691 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 692 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 693 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-pyridyl 
               
               
                 694 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-pyridyl 
               
               
                 695 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-pyridyl 
               
               
                 696 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-thiazolyl 
               
               
                 697 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-pyrazolyl 
               
               
                 698 
                 H 2 NCH 2 CH 2 NHCH 2   
                 5-isoquinolyl 
               
               
                 699 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 700 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 701 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-imidazolyl 
               
               
                 702 
                 H 2 NCH 2 CH 2 NHCH 2   
                 2-oxazolyl 
               
               
                 703 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-isoxazolyl 
               
               
                 704 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-HOC 6 H 4   
               
               
                 705 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-HOC 6 H 4   
               
               
                 706 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3,4-diHOC 6 H 4   
               
               
                 707 
                 H 2 NCH 2 CH 2 NHCH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 708 
                 H 2 NCH 2 CH 2 NHCH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 709 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-MeOC 6 H 4   
               
               
                 710 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-MeOC 6 H 4   
               
               
                 711 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-NH 2 C 6 H 4   
               
               
                 712 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-NH 2 C 6 H 4   
               
               
                 713 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-NH 2 C 6 H 4   
               
               
                 714 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 715 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 716 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 717 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-pyridyl 
               
               
                 718 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-pyridyl 
               
               
                 719 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-pyridyl 
               
               
                 720 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-thiazolyl 
               
               
                 721 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-pyrazolyl 
               
               
                 722 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 5-isoquinolyl 
               
               
                 723 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 724 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 725 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-imidazolyl 
               
               
                 726 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 2-oxazolyl 
               
               
                 727 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-isoxazolyl 
               
               
                 728 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-HOC 6 H 4   
               
               
                 729 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-HOC 6 H 4   
               
               
                 730 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3,4-diHOC 6 H 4   
               
               
                 731 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 732 
                 Me 2 NCH 2 CH 2 NHCH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 733 
                 1-morpholinylmethyl 
                 3-MeOC 6 H 4   
               
               
                 734 
                 1-morpholinylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 735 
                 1-morpholinylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 736 
                 1-morpholinylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 737 
                 1-morpholinylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 738 
                 1-morpholinylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 739 
                 1-morpholinylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 740 
                 1-morpholinylmethyl 
                 4-pyridyl 
               
               
                 741 
                 1-morpholinylmethyl 
                 3-pyridyl 
               
               
                 742 
                 1-morpholinylmethyl 
                 2-pyridyl 
               
               
                 743 
                 1-morpholinylmethyl 
                 2-thiazolyl 
               
               
                 744 
                 1-morpholinylmethyl 
                 2-pyrazolyl 
               
               
                 745 
                 1-morpholinylmethyl 
                 5-isoquinolyl 
               
               
                 746 
                 1-morpholinylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 747 
                 1-morpholinylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 748 
                 1-morpholinylmethyl 
                 2-imidazolyl 
               
               
                 749 
                 1-morpholinylmethyl 
                 2-oxazolyl 
               
               
                 750 
                 1-morpholinylmethyl 
                 4-isoxazolyl 
               
               
                 751 
                 1-morpholinylmethyl 
                 4-HOC 6 H 4   
               
               
                 752 
                 1-morpholinylmethyl 
                 3-HOC 6 H 4   
               
               
                 753 
                 1-morpholinylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 754 
                 1-morpholinylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 755 
                 1-morpholinylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 756 
                 1-thiomorpholinylmethyl 
                 3-MeOC 6 H 4   
               
               
                 757 
                 1-thiomorpholinylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 758 
                 1-thiomorpholinylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 759 
                 1-thiomorpholinylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 760 
                 1-thiomorpholinylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 761 
                 1-thiomorpholinylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 762 
                 1-thiomorpholinylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 763 
                 1-thiomorpholinylmethyl 
                 4-pyridyl 
               
               
                 764 
                 1-thiomorpholinylmethyl 
                 3-pyridyl 
               
               
                 765 
                 1-thiomorpholinylmethyl 
                 2-pyridyl 
               
               
                 766 
                 1-thiomorpholinylmethyl 
                 2-thiazolyl 
               
               
                 767 
                 1-thiomorpholinylmethyl 
                 2-pyrazolyl 
               
               
                 768 
                 1-thiomorpholinylmethyl 
                 5-isoquinolyl 
               
               
                 769 
                 1-thiomorpholinylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 770 
                 1-thiomorpholinylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 771 
                 1-thiomorpholinylmethyl 
                 2-imidazolyl 
               
               
                 772 
                 1-thiomorpholinylmethyl 
                 2-oxazolyl 
               
               
                 773 
                 1-thiomorpholinylmethyl 
                 4-isoxazolyl 
               
               
                 774 
                 1-thiomorpholinylmethyl 
                 4-HOC 6 H 4   
               
               
                 775 
                 1-thiomorpholinylmethyl 
                 3-HOC 6 H 4   
               
               
                 776 
                 1-thiomorpholinylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 777 
                 1-thiomorpholinylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 778 
                 1-thiomorpholinylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 779 
                 1-piperazinylmethyl 
                 3-MeOC 6 H 4   
               
               
                 780 
                 1-piperazinylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 781 
                 1-piperazinylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 782 
                 1-piperazinylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 783 
                 1-piperazinylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 784 
                 1-piperazinylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 785 
                 1-piperazinylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 786 
                 1-piperazinylmethyl 
                 4-pyridyl 
               
               
                 787 
                 1-piperazinylmethyl 
                 3-pyridyl 
               
               
                 788 
                 1-piperazinylmethyl 
                 2-pyridyl 
               
               
                 789 
                 1-piperazinylmethyl 
                 2-thiazolyl 
               
               
                 790 
                 1-piperazinylmethyl 
                 2-pyrazolyl 
               
               
                 791 
                 1-piperazinylmethyl 
                 5-isoquinolyl 
               
               
                 792 
                 1-piperazinylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 793 
                 1-piperazinylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 794 
                 1-piperazinylmethyl 
                 2-imidazolyl 
               
               
                 795 
                 1-piperazinylmethyl 
                 2-oxazolyl 
               
               
                 796 
                 1-piperazinylmethyl 
                 4-isoxazolyl 
               
               
                 797 
                 1-piperazinylmethyl 
                 4-HOC 6 H 4   
               
               
                 798 
                 1-piperazinylmethyl 
                 3-HOC 6 H 4   
               
               
                 799 
                 1-piperazinylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 800 
                 1-piperazinylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 801 
                 1-piperazinylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Example 
                   
                   
               
               
                 Number 
                 R 1   
                 R 2   
               
               
                   
               
             
          
           
               
                 802 
                 2-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 803 
                 2-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 804 
                 2-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 805 
                 2-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 806 
                 2-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 807 
                 2-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 808 
                 2-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 809 
                 2-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 810 
                 2-pyridylmethyl 
                 4-pyridyl 
               
               
                 811 
                 2-pyridylmethyl 
                 3-pyridyl 
               
               
                 812 
                 2-pyridylmethyl 
                 2-pyridyl 
               
               
                 813 
                 2-pyridylmethyl 
                 2-thiazolyl 
               
               
                 814 
                 2-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 815 
                 2-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 816 
                 2-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 817 
                 2-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 818 
                 2-pyridylmethyl 
                 2-imidazolyl 
               
               
                 819 
                 2-pyridylmethyl 
                 2-oxazolyl 
               
               
                 820 
                 2-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 821 
                 2-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 822 
                 2-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 823 
                 2-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 824 
                 2-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 825 
                 2-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 826 
                 3-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 827 
                 3-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 828 
                 3-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 829 
                 3-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 830 
                 3-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 831 
                 3-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 832 
                 3-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 833 
                 3-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 834 
                 3-pyridylmethyl 
                 4-pyridyl 
               
               
                 835 
                 3-pyridylmethyl 
                 3-pyridyl 
               
               
                 836 
                 3-pyridylmethyl 
                 2-pyridyl 
               
               
                 837 
                 3-pyridylmethyl 
                 2-thiazolyl 
               
               
                 838 
                 3-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 839 
                 3-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 840 
                 3-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 841 
                 3-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 842 
                 3-pyridylmethyl 
                 2-imidazolyl 
               
               
                 843 
                 3-pyridylmethyl 
                 2-oxazolyl 
               
               
                 844 
                 3-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 845 
                 3-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 846 
                 3-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 847 
                 3-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 848 
                 3-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 849 
                 3-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 850 
                 4-pyridylmethyl 
                 4-MeOC 6 H 4   
               
               
                 851 
                 4-pyridylmethyl 
                 3-MeOC 6 H 4   
               
               
                 852 
                 4-pyridylmethyl 
                 4-NH 2 C 6 H 4   
               
               
                 853 
                 4-pyridylmethyl 
                 3-NH 2 C 6 H 4   
               
               
                 854 
                 4-pyridylmethyl 
                 2-NH 2 C 6 H 4   
               
               
                 855 
                 4-pyridylmethyl 
                 4-Me 2 NC 6 H 4   
               
               
                 856 
                 4-pyridylmethyl 
                 3-Me 2 NC 6 H 4   
               
               
                 857 
                 4-pyridylmethyl 
                 2-Me 2 NC 6 H 4   
               
               
                 858 
                 4-pyridylmethyl 
                 4-pyridyl 
               
               
                 859 
                 4-pyridylmethyl 
                 3-pyridyl 
               
               
                 860 
                 4-pyridylmethyl 
                 2-pyridyl 
               
               
                 861 
                 4-pyridylmethyl 
                 2-thiazolyl 
               
               
                 862 
                 4-pyridylmethyl 
                 2-pyrazolyl 
               
               
                 863 
                 4-pyridylmethyl 
                 5-isoquinolyl 
               
               
                 864 
                 4-pyridylmethyl 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 865 
                 4-pyridylmethyl 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 866 
                 4-pyridylmethyl 
                 2-imidazolyl 
               
               
                 867 
                 4-pyridylmethyl 
                 2-oxazolyl 
               
               
                 868 
                 4-pyridylmethyl 
                 4-isoxazolyl 
               
               
                 869 
                 4-pyridylmethyl 
                 4-HOC 6 H 4   
               
               
                 870 
                 4-pyridylmethyl 
                 3-HOC 6 H 4   
               
               
                 871 
                 4-pyridylmethyl 
                 3,4-diHOC 6 H 4   
               
               
                 872 
                 4-pyridylmethyl 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 873 
                 4-pyridylmethyl 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 874 
                 2-NH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 875 
                 2-NH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 876 
                 2-NH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 877 
                 2-NH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 878 
                 2-NH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 879 
                 2-NH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 880 
                 2-NH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 881 
                 2-NH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 882 
                 2-NH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 883 
                 2-NH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 884 
                 2-NH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 885 
                 2-NH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 886 
                 2-NH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 887 
                 2-NH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 888 
                 2-NH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 889 
                 2-NH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 890 
                 2-NH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 891 
                 2-NH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 892 
                 2-NH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 893 
                 2-NH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 894 
                 2-NH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 895 
                 2-NH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 896 
                 2-NH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 897 
                 2-NH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 898 
                 3-NH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 899 
                 3-NH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 900 
                 3-NH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 901 
                 3-NH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 902 
                 3-NH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 903 
                 3-NH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 904 
                 3-NH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 905 
                 3-NH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 906 
                 3-NH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 907 
                 3-NH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 908 
                 3-NH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 909 
                 3-NH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 910 
                 3-NH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 911 
                 3-NH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 912 
                 3-NH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 913 
                 3-NH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 914 
                 3-NH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 915 
                 3-NH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 916 
                 3-NH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 917 
                 3-NH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 918 
                 3-NH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 919 
                 3-NH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 920 
                 3-NH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 921 
                 3-NH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 922 
                 4-NH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 923 
                 4-NH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 924 
                 4-NH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 925 
                 4-NH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 926 
                 4-NH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 927 
                 4-NH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 928 
                 4-NH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 930 
                 4-NH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 931 
                 4-NH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 932 
                 4-NH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 933 
                 4-NH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 934 
                 4-NH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 935 
                 4-NH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 936 
                 4-NH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 937 
                 4-NH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 938 
                 4-NH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 939 
                 4-NH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 940 
                 4-NH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 941 
                 4-NH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 942 
                 4-NH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 943 
                 4-NH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 944 
                 4-NH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 945 
                 4-NH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 946 
                 4-NH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 947 
                 2-MeOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 948 
                 2-MeOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 949 
                 2-MeOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 950 
                 2-MeOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 951 
                 2-MeOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 952 
                 2-MeOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 953 
                 2-MeOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 954 
                 2-MeOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 955 
                 2-MeOC 6 H 4   
                 4-pyridyl 
               
               
                 956 
                 2-MeOC 6 H 4   
                 3-pyridyl 
               
               
                 957 
                 2-MeOC 6 H 4   
                 2-pyridyl 
               
               
                 958 
                 2-MeOC 6 H 4   
                 2-thiazolyl 
               
               
                 959 
                 2-MeOC 6 H 4   
                 2-pyrazolyl 
               
               
                 960 
                 2-MeOC 6 H 4   
                 5-isoquinolyl 
               
               
                 961 
                 2-MeOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 962 
                 2-MeOC 6 H 4   
                 3-4-ethylenedioxyC 6 H 3   
               
               
                 963 
                 2-MeOC 6 H 4   
                 2-imidazolyl 
               
               
                 964 
                 2-MeOC 6 H 4   
                 2-oxazolyl 
               
               
                 965 
                 2-MeOC 6 H 4   
                 4-isoxazolyl 
               
               
                 966 
                 2-MeOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 967 
                 2-MeOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 968 
                 2-MeOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 969 
                 2-MeOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 970 
                 2-MeOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 971 
                 3-MeOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 972 
                 3-MeOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 973 
                 3-MeOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 974 
                 3-MeOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 975 
                 3-MeOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 976 
                 3-MeOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 977 
                 3-MeOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 978 
                 3-MeOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 979 
                 3-MeOC 6 H 4   
                 4-pyridyl 
               
               
                 980 
                 3-MeOC 6 H 4   
                 3-pyridyl 
               
               
                 981 
                 3-MeOC 6 H 4   
                 2-pyridyl 
               
               
                 982 
                 3-MeOC 6 H 4   
                 2-thiazolyl 
               
               
                 983 
                 3-MeOC 6 H 4   
                 2-pyrazolyl 
               
               
                 984 
                 3-MeOC 6 H 4   
                 5-isoquinolyl 
               
               
                 985 
                 3-MeOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 986 
                 3-MeOC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 987 
                 3-MeOC 6 H 4   
                 2-imidazolyl 
               
               
                 988 
                 3-MeOC 6 H 4   
                 2-oxazolyl 
               
               
                 989 
                 3-MeOC 6 H 4   
                 4-isoxazolyl 
               
               
                 990 
                 3-MeOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 991 
                 3-MeOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 992 
                 3-MeOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 993 
                 3-MeOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 994 
                 3-MeOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 995 
                 4-MeOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 996 
                 4-MeOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 997 
                 4-MeOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 998 
                 4-MeOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 999 
                 4-MeOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1000 
                 4-MeOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1001 
                 4-MeOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1002 
                 4-MeOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1003 
                 4-MeOC 6 H 4   
                 4-pyridyl 
               
               
                 1004 
                 4-MeOC 6 H 4   
                 3-pyridyl 
               
               
                 1005 
                 4-MeOC 6 H 4   
                 2-pyridyl 
               
               
                 1006 
                 4-MeOC 6 H 4   
                 2-thiazolyl 
               
               
                 1007 
                 4-MeOC 6 H 4   
                 2-pyrazolyl 
               
               
                 1008 
                 4-MeOC 6 H 4   
                 5-isoquinolyl 
               
               
                 1009 
                 4-MeOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1010 
                 4-MeOC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1011 
                 4-MeOC 6 H 4   
                 2-imidazolyl 
               
               
                 1012 
                 4-MeOC 6 H 4   
                 2-oxazolyl 
               
               
                 1013 
                 4-MeOC 6 H 4   
                 4-isoxazolyl 
               
               
                 1014 
                 4-MeOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1015 
                 4-MeOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1016 
                 4-MeOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1017 
                 4-MeOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1018 
                 4-MeOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1019 
                 2-HOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1020 
                 2-HOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1021 
                 2-HOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1022 
                 2-HOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1023 
                 2-HOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1024 
                 2-HOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1025 
                 2-HOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1026 
                 2-HOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1027 
                 2-HOC 6 H 4   
                 4-pyridyl 
               
               
                 1028 
                 2-HOC 6 H 4   
                 3-pyridyl 
               
               
                 1029 
                 2-HOC 6 H 4   
                 2-pyridyl 
               
               
                 1030 
                 2-HOC 6 H 4   
                 2-thiazolyl 
               
               
                 1031 
                 2-HOC 6 H 4   
                 2-pyrazolyl 
               
               
                 1032 
                 2-HOC 6 H 4   
                 5-isoquinolyl 
               
               
                 1033 
                 2-HOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1034 
                 2-HOC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1035 
                 2-HOC 6 H 4   
                 2-imidazolyl 
               
               
                 1036 
                 2-HOC 6 H 4   
                 2-oxazolyl 
               
               
                 1037 
                 2-HOC 6 H 4   
                 4-isoxazolyl 
               
               
                 1038 
                 2-HOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1039 
                 2-HOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1040 
                 2-HOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1041 
                 2-HOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1042 
                 2-HOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1043 
                 3-HOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1044 
                 3-HOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1045 
                 3-HOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1046 
                 3-HOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1047 
                 3-HOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1048 
                 3-HOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1049 
                 3-HOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1050 
                 3-HOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1051 
                 3-HOC 6 H 4   
                 4-pyridyl 
               
               
                 1052 
                 3-HOC 6 H 4   
                 3-pyridyl 
               
               
                 1053 
                 3-HOC 6 H 4   
                 2-pyridyl 
               
               
                 1054 
                 3-HOC 6 H 4   
                 2-thiazolyl 
               
               
                 1055 
                 3-HOC 6 H 4   
                 2-pyrazolyl 
               
               
                 1056 
                 3-HOC 6 H 4   
                 5-isoquinolyl 
               
               
                 1057 
                 3-HOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1058 
                 3-HOC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1059 
                 3-HOC 6 H 4   
                 2-imidazolyl 
               
               
                 1060 
                 3-HOC 6 H 4   
                 2-oxazolyl 
               
               
                 1061 
                 3-HOC 6 H 4   
                 4-isoxazolyl 
               
               
                 1062 
                 3-HOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1063 
                 3-HOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1064 
                 3-HOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1065 
                 3-HOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1066 
                 3-HOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1067 
                 4-HOC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1068 
                 4-HOC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1069 
                 4-HOC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1070 
                 4-HOC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1071 
                 4-HOC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1072 
                 4-HOC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1073 
                 4-HOC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1074 
                 4-HOC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1075 
                 4-HOC 6 H 4   
                 4-pyridyl 
               
               
                 1076 
                 4-HOC 6 H 4   
                 3-pyridyl 
               
               
                 1077 
                 4-HOC 6 H 4   
                 2-pyridyl 
               
               
                 1078 
                 4-HOC 6 H 4   
                 2-thiazolyl 
               
               
                 1079 
                 4-HOC 6 H 4   
                 2-pyrazolyl 
               
               
                 1080 
                 4-HOC 6 H 4   
                 5-isoquinolyl 
               
               
                 1081 
                 4-HOC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1082 
                 4-HOC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1083 
                 4-HOC 6 H 4   
                 2-imidazolyl 
               
               
                 1084 
                 4-HOC 6 H 4   
                 2-oxazolyl 
               
               
                 1085 
                 4-HOC 6 H 4   
                 4-isoxazolyl 
               
               
                 1086 
                 4-HOC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1087 
                 4-HOC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1088 
                 4-HOC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1089 
                 4-HOC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1090 
                 4-HOC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1091 
                 4-ClC 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1092 
                 4-ClC 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1093 
                 4-ClC 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1094 
                 4-ClC 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1095 
                 4-ClC 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1096 
                 4-ClC 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1097 
                 4-ClC 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1098 
                 4-ClC 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1099 
                 4-ClC 6 H 4   
                 4-pyridyl 
               
               
                 1100 
                 4-ClC 6 H 4   
                 3-pyridyl 
               
               
                 1101 
                 4-ClC 6 H 4   
                 2-pyridyl 
               
               
                 1102 
                 4-ClC 6 H 4   
                 2-thiazolyl 
               
               
                 1103 
                 4-ClC 6 H 4   
                 2-pyrazolyl 
               
               
                 1104 
                 4-ClC 6 H 4   
                 5-isoquinolyl 
               
               
                 1105 
                 4-ClC 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1106 
                 4-ClC 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1107 
                 4-ClC 6 H 4   
                 2-imidazolyl 
               
               
                 1108 
                 4-ClC 6 H 4   
                 2-oxazolyl 
               
               
                 1109 
                 4-ClC 6 H 4   
                 4-isoxazolyl 
               
               
                 1110 
                 4-ClC 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1111 
                 4-ClC 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1112 
                 4-ClC 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1113 
                 4-ClC 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1114 
                 4-ClC 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1115 
                 2-NH 2 CH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1116 
                 2-NH 2 CH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1117 
                 2-NH 2 CH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1118 
                 2-NH 2 CH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1119 
                 2-NH 2 CH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1120 
                 2-NH 2 CH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1121 
                 2-NH 2 CH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1122 
                 2-NH 2 CH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1123 
                 2-NH 2 CH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1124 
                 2-NH 2 CH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1125 
                 2-NH 2 CH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1126 
                 2-NH 2 CH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1127 
                 2-NH 2 CH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1128 
                 2-NH 2 CH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1129 
                 2-NH 2 CH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1130 
                 2-NH 2 CH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1131 
                 2-NH 2 CH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1132 
                 2-NH 2 CH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1133 
                 2-NH 2 CH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1134 
                 2-NH 2 CH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1135 
                 2-NH 2 CH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1136 
                 2-NH 2 CH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1137 
                 2-NH 2 CH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1138 
                 2-NH 2 CH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1139 
                 3-NH 2 CH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1140 
                 3-NH 2 CH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1141 
                 3-NH 2 CH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1142 
                 3-NH 2 CH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1143 
                 3-NH 2 CH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1144 
                 3-NH 2 CH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1145 
                 3-NH 2 CH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1146 
                 3-NH 2 CH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1147 
                 3-NH 2 CH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1148 
                 3-NH 2 CH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1149 
                 3-NH 2 CH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1150 
                 3-NH 2 CH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1151 
                 3-NH 2 CH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1152 
                 3-NH 2 CH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1153 
                 3-NH 2 CH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1154 
                 3-NH 2 CH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1155 
                 3-NH 2 CH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1156 
                 3-NH 2 CH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1157 
                 3-NH 2 CH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1158 
                 3-NH 2 CH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1159 
                 3-NH 2 CH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1160 
                 3-NH 2 CH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1161 
                 3-NH 2 CH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1162 
                 3-NH 2 CH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1163 
                 4-NH 2 CH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1164 
                 4-NH 2 CH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1165 
                 4-NH 2 CH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1166 
                 4-NH 2 CH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1167 
                 4-NH 2 CH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1168 
                 4-NH 2 CH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1169 
                 4-NH 2 CH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1170 
                 4-NH 2 CH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1171 
                 4-NH 2 CH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1172 
                 4-NH 2 CH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1173 
                 4-NH 2 CH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1174 
                 4-NH 2 CH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1175 
                 4-NH 2 CH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1176 
                 4-NH 2 CH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1177 
                 4-NH 2 CH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1178 
                 4-NH 2 CH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1179 
                 4-NH 2 CH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1180 
                 4-NH 2 CH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1181 
                 4-NH 2 CH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1182 
                 4-NH 2 CH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1183 
                 4-NH 2 CH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1184 
                 4-NH 2 CH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1185 
                 4-NH 2 CH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1186 
                 4-NH 2 CH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1187 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1188 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1189 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1190 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1191 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1192 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1193 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1194 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1195 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1196 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1197 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1198 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1199 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1200 
                 2-Me 2 NCH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1201 
                 2-Me 2 NCH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1202 
                 2-Me 2 NCH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1203 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1204 
                 2-Me 2 NCH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1205 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1206 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1207 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1208 
                 2-Me 2 NCH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1209 
                 2-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1210 
                 2-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1211 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1212 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1213 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1214 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1215 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1216 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1217 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1218 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1219 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1220 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1221 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1222 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1223 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1224 
                 3-Me 2 NCH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1225 
                 3-Me 2 NCH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1226 
                 3-Me 2 NCH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1227 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1228 
                 3-Me 2 NCH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1229 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1230 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1231 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1232 
                 3-Me 2 NCH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1233 
                 3-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1234 
                 3-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1235 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-MeOC 6 H 4   
               
               
                 1236 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-MeOC 6 H 4   
               
               
                 1237 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 C 6 H 4   
               
               
                 1238 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 C 6 H 4   
               
               
                 1239 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-NH 2 C 6 H 4   
               
               
                 1240 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-Me 2 NC 6 H 4   
               
               
                 1241 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-Me 2 NC 6 H 4   
               
               
                 1242 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-Me 2 NC 6 H 4   
               
               
                 1243 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-pyridyl 
               
               
                 1244 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-pyridyl 
               
               
                 1245 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-pyridyl 
               
               
                 1246 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-thiazolyl 
               
               
                 1247 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-pyrazolyl 
               
               
                 1248 
                 4-Me 2 NCH 2 C 6 H 4   
                 5-isoquinolyl 
               
               
                 1249 
                 4-Me 2 NCH 2 C 6 H 4   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1250 
                 4-Me 2 NCH 2 C 6 H 4   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1251 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-imidazolyl 
               
               
                 1252 
                 4-Me 2 NCH 2 C 6 H 4   
                 2-oxazolyl 
               
               
                 1253 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-isoxazolyl 
               
               
                 1254 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-HOC 6 H 4   
               
               
                 1255 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-HOC 6 H 4   
               
               
                 1256 
                 4-Me 2 NCH 2 C 6 H 4   
                 3,4-diHOC 6 H 4   
               
               
                 1257 
                 4-Me 2 NCH 2 C 6 H 4   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1258 
                 4-Me 2 NCH 2 C 6 H 4   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1259 
                 H 
                 4-MeOC 6 H 4   
               
               
                 1260 
                 H 
                 3-MeOC 6 H 4   
               
               
                 1261 
                 H 
                 4-NH 2 C 6 H 4   
               
               
                 1262 
                 H 
                 3-NH 2 C 6 H 4   
               
               
                 1263 
                 H 
                 2-NH 2 C 6 H 4   
               
               
                 1264 
                 H 
                 4-Me 2 NC 6 H 4   
               
               
                 1265 
                 H 
                 3-Me 2 NC 6 H 4   
               
               
                 1266 
                 H 
                 2-Me 2 NC 6 H 4   
               
               
                 1267 
                 H 
                 4-pyridyl 
               
               
                 1268 
                 H 
                 3-pyridyl 
               
               
                 1269 
                 H 
                 2-pyridyl 
               
               
                 1270 
                 H 
                 2-thiazolyl 
               
               
                 1271 
                 H 
                 2-pyrazolyl 
               
               
                 1272 
                 H 
                 5-isoquinolyl 
               
               
                 1273 
                 H 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1274 
                 H 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1275 
                 H 
                 2-imidazolyl 
               
               
                 1276 
                 H 
                 2-oxazolyl 
               
               
                 1277 
                 H 
                 4-isoxazolyl 
               
               
                 1278 
                 H 
                 4-HOC 6 H 4   
               
               
                 1279 
                 H 
                 3-HOC 6 H 4   
               
               
                 1280 
                 H 
                 3,4-diHOC 6 H 4   
               
               
                 1281 
                 H 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1282 
                 H 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1283 
                 Me 
                 4-MeOC 6 H 4   
               
               
                 1284 
                 Me 
                 3-MeOC 6 H 4   
               
               
                 1285 
                 Me 
                 4-NH 2 C 6 H 4   
               
               
                 1286 
                 Me 
                 3-NH 2 C 6 H 4   
               
               
                 1287 
                 Me 
                 2-NH 2 C 6 H 4   
               
               
                 1288 
                 Me 
                 4-Me 2 NC 6 H 4   
               
               
                 1289 
                 Me 
                 3-Me 2 NC 6 H 4   
               
               
                 1290 
                 Me 
                 2-Me 2 NC 6 H 4   
               
               
                 1291 
                 Me 
                 4-pyridyl 
               
               
                 1292 
                 Me 
                 3-pyridyl 
               
               
                 1293 
                 Me 
                 2-pyridyl 
               
               
                 1294 
                 Me 
                 2-thiazolyl 
               
               
                 1295 
                 Me 
                 2-pyrazolyl 
               
               
                 1296 
                 Me 
                 5-isoquinolyl 
               
               
                 1297 
                 Me 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1298 
                 Me 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1299 
                 Me 
                 2-imidazolyl 
               
               
                 1300 
                 Me 
                 2-oxazolyl 
               
               
                 1301 
                 Me 
                 4-isoxazolyl 
               
               
                 1302 
                 Me 
                 4-HOC 6 H 4   
               
               
                 1303 
                 Me 
                 3-HOC 6 H 4   
               
               
                 1304 
                 Me 
                 3,4-diHOC 6 H 4   
               
               
                 1305 
                 Me 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1306 
                 Me 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1307 
                 Et 
                 4-MeOC 6 H 4   
               
               
                 1308 
                 Et 
                 3-MeOC 6 H 4   
               
               
                 1309 
                 Et 
                 4-NH 2 C 6 H 4   
               
               
                 1310 
                 Et 
                 3-NH 2 C 6 H 4   
               
               
                 1311 
                 Et 
                 2-NH 2 C 6 H 4   
               
               
                 1312 
                 Et 
                 4-Me 2 NC 6 H 4   
               
               
                 1313 
                 Et 
                 3-Me 2 NC 6 H 4   
               
               
                 1314 
                 Et 
                 2-Me 2 NC 6 H 4   
               
               
                 1315 
                 Et 
                 4-pyridyl 
               
               
                 1316 
                 Et 
                 3-pyridyl 
               
               
                 1317 
                 Et 
                 2-pyridyl 
               
               
                 1318 
                 Et 
                 2-thiazolyl 
               
               
                 1319 
                 Et 
                 2-pyrazolyl 
               
               
                 1320 
                 Et 
                 5-isoquinolyl 
               
               
                 1321 
                 Et 
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1322 
                 Et 
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1323 
                 Et 
                 2-imidazolyl 
               
               
                 1324 
                 Et 
                 2-oxazolyl 
               
               
                 1325 
                 Et 
                 4-isoxazolyl 
               
               
                 1326 
                 Et 
                 4-HOC 6 H 4   
               
               
                 1327 
                 Et 
                 3-HOC 6 H 4   
               
               
                 1328 
                 Et 
                 3,4-diHOC 6 H 4   
               
               
                 1329 
                 Et 
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1330 
                 Et 
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1331 
                 2-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1332 
                 2-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1333 
                 2-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1334 
                 2-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1335 
                 2-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1336 
                 2-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1337 
                 2-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1338 
                 2-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1339 
                 2-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1340 
                 2-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1341 
                 2-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1342 
                 2-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1343 
                 2-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1344 
                 2-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1345 
                 2-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1346 
                 2-NH 2 C 6 H 4 CH 2   
                 3-4-ethylenedioxyC 6 H 3   
               
               
                 1347 
                 2-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1348 
                 2-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1349 
                 2-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1350 
                 2-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1351 
                 2-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1352 
                 2-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1353 
                 2-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1354 
                 2-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1355 
                 3-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1356 
                 3-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1357 
                 3-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1358 
                 3-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1359 
                 3-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1360 
                 3-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1361 
                 3-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1362 
                 3-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1363 
                 3-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1364 
                 3-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1365 
                 3-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1366 
                 3-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1367 
                 3-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1367 
                 3-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1369 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1370 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1371 
                 3-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1372 
                 3-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1373 
                 3-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1374 
                 3-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1375 
                 3-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1376 
                 3-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1377 
                 3-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1378 
                 3-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1379 
                 4-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1380 
                 4-NH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1381 
                 4-NH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1382 
                 4-NH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1383 
                 4-NH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1384 
                 4-NH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1385 
                 4-NH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1386 
                 4-NH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1387 
                 4-NH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1388 
                 4-NH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1389 
                 4-NH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1390 
                 4-NH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1391 
                 4-NH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1392 
                 4-NH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1393 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1394 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1395 
                 4-NH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1396 
                 4-NH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1397 
                 4-NH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1398 
                 4-NH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1399 
                 4-NH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1400 
                 4-NH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1401 
                 4-NH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1402 
                 4-NH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1403 
                 2-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1404 
                 2-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1405 
                 2-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1406 
                 2-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1407 
                 2-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1408 
                 2-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1409 
                 2-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1410 
                 2-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1411 
                 2-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1412 
                 2-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1413 
                 2-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1414 
                 2-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1415 
                 2-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1416 
                 2-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1417 
                 2-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1418 
                 2-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1419 
                 2-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1420 
                 2-MeOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1421 
                 2-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1422 
                 2-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1423 
                 2-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1424 
                 2-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1425 
                 2-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1426 
                 2-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1427 
                 3-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1428 
                 3-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1429 
                 3-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1430 
                 3-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1431 
                 3-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1432 
                 3-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1433 
                 3-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1434 
                 3-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1435 
                 3-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1436 
                 3-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1437 
                 3-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1438 
                 3-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1439 
                 3-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1440 
                 3-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1441 
                 3-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1442 
                 3-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1443 
                 3-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1444 
                 3-MeOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1445 
                 3-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1446 
                 3-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1447 
                 3-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1448 
                 3-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1449 
                 3-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1450 
                 3-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1451 
                 4-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1452 
                 4-MeOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1453 
                 4-MeOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1454 
                 4-MeOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1455 
                 4-MeOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1456 
                 4-MeOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1457 
                 4-MeOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1458 
                 4-MeOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1459 
                 4-MeOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1460 
                 4-MeOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1461 
                 4-MeOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1462 
                 4-MeOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1463 
                 4-MeOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1464 
                 4-MeOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1465 
                 4-MeOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1466 
                 4-MeOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1467 
                 4-MeOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1468 
                 4-MeOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1469 
                 4-MeOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1470 
                 4-MeOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1471 
                 4-MeOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1472 
                 4-MeOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1473 
                 4-MeOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1474 
                 4-MeOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1475 
                 2-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1476 
                 2-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1477 
                 2-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1478 
                 2-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1479 
                 2-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1480 
                 2-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1481 
                 2-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1482 
                 2-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1483 
                 2-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1484 
                 2-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1485 
                 2-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1486 
                 2-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1487 
                 2-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1488 
                 2-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1489 
                 2-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1490 
                 2-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1491 
                 2-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1492 
                 2-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1493 
                 2-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1494 
                 2-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1495 
                 2-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1496 
                 2-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1497 
                 2-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1498 
                 2-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1499 
                 3-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1500 
                 3-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1501 
                 3-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1502 
                 3-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1503 
                 3-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1504 
                 3-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1505 
                 3-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1506 
                 3-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1507 
                 3-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1508 
                 3-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1509 
                 3-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1510 
                 3-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1511 
                 3-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1512 
                 3-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1513 
                 3-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1514 
                 3-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1514 
                 3-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1516 
                 3-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1517 
                 3-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1518 
                 3-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1519 
                 3-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1520 
                 3-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1521 
                 3-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1522 
                 3-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1523 
                 4-HOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1524 
                 4-HOC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1525 
                 4-HOC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1526 
                 4-HOC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1527 
                 4-HOC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1528 
                 4-HOC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1529 
                 4-HOC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1530 
                 4-HOC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1531 
                 4-HOC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1532 
                 4-HOC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1533 
                 4-HOC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1534 
                 4-HOC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1535 
                 4-HOC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1536 
                 4-HOC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1537 
                 4-HOC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1538 
                 4-HOC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1539 
                 4-HOC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1540 
                 4-HOC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1541 
                 4-HOC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1542 
                 4-HOC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1543 
                 4-HOC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1544 
                 4-HOC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1545 
                 4-HOC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1546 
                 4-HOC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1547 
                 4-ClC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1548 
                 4-ClC 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1549 
                 4-ClC 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1550 
                 4-ClC 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1551 
                 4-ClC 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1552 
                 4-ClC 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1553 
                 4-ClC 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1554 
                 4-ClC 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1555 
                 4-ClC 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1556 
                 4-ClC 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1557 
                 4-ClC 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1558 
                 4-ClC 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1559 
                 4-ClC 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1560 
                 4-ClC 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1561 
                 4-ClC 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1562 
                 4-ClC 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1563 
                 4-ClC 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1564 
                 4-ClC 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1565 
                 4-ClC 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1566 
                 4-ClC 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1567 
                 4-ClC 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1568 
                 4-ClC 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1569 
                 4-ClC 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1570 
                 4-ClC 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1571 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1572 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1573 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1574 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1575 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1576 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1577 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1578 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1579 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1580 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1581 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1582 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1583 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1584 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1585 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1586 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1587 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1588 
                 N-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1589 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1590 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1591 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1592 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1593 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1594 
                 2-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1595 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1596 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1597 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1598 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1599 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1600 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1601 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1602 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1603 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1604 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1605 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1606 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1607 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1608 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1609 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1610 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1611 
                 3-NH 2 CH 2 C 6 H 4CH   2   
                 2-imidazolyl 
               
               
                 1612 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1613 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1614 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1615 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1616 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1617 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1618 
                 3-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1619 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1620 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1621 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1622 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1623 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1624 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1625 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1626 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1627 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1628 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1629 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1630 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1631 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1632 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1633 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1634 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1635 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1636 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1637 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1638 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1639 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1640 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1641 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1642 
                 4-NH 2 CH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1643 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1644 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1645 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1646 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1647 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1648 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1649 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1650 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1651 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1652 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1653 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1654 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1655 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1656 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1657 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1658 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1659 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1660 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1661 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1662 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1663 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1664 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1665 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1666 
                 2-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1667 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1668 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1669 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1670 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1671 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1672 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1673 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1674 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1675 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1676 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1677 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1678 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1679 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1680 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1681 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1682 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1683 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1684 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1685 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1686 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1687 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1688 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1689 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1690 
                 3-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                 1691 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1692 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-MeOC 6 H 4   
               
               
                 1693 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 C 6 H 4   
               
               
                 1694 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 C 6 H 4   
               
               
                 1695 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-NH 2 C 6 H 4   
               
               
                 1696 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1697 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-Me 2 NC 6 H 4   
               
               
                 1698 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-Me 2 NC 6 H 4   
               
               
                 1699 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-pyridyl 
               
               
                 1700 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-pyridyl 
               
               
                 1701 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyridyl 
               
               
                 1702 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-thiazolyl 
               
               
                 1703 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-pyrazolyl 
               
               
                 1704 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 5-isoquinolyl 
               
               
                 1705 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-methylenedioxyC 6 H 3   
               
               
                 1706 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-ethylenedioxyC 6 H 3   
               
               
                 1707 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-imidazolyl 
               
               
                 1708 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 2-oxazolyl 
               
               
                 1709 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-isoxazolyl 
               
               
                 1710 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-HOC 6 H 4   
               
               
                 1711 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-HOC 6 H 4   
               
               
                 1712 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3,4-diHOC 6 H 4   
               
               
                 1713 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 4-NH 2 CH 2 C 6 H 4   
               
               
                 1714 
                 4-Me 2 NCH 2 C 6 H 4 CH 2   
                 3-NH 2 CH 2 C 6 H 4   
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Example 
                   
                   
               
               
                 Number 
                 R 1   
                 R 2   
               
               
                   
               
               
                 1715 
                 Methyl 
                 4-MeOC 6 H 4   
               
               
                 1716 
                 ClCH 2   
                 4-MeOC 6 H 4   
               
               
                 1717 
                 Cyclopropyl 
                 4-MeOC 6 H 4   
               
               
                 1718 
                 Isopropyl 
                 4-MeOC 6 H 4   
               
               
                 1719 
                 Ethyl 
                 4-MeOC 6 H 4   
               
               
                 1720 
                 Cyclopentyl 
                 4-MeOC 6 H 4   
               
               
                 1721 
                 Cyclobutyl 
                 4-MeOC 6 H 4   
               
               
                 1722 
                 Benzyl 
                 4-MeOC 6 H 4   
               
               
                 1723 
                 n-propyl 
                 4-MeOC 6 H 4   
               
               
                 1724 
                 4-ClC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1725 
                 3-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1726 
                 4-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1727 
                 3,4-diMeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1728 
                 2,5-diMeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1729 
                 Methyl 
                 2-MeOC 6 H 4   
               
               
                 1730 
                 Methyl 
                 3,4-diMeOC 6 H 4   
               
               
                 1731 
                 3,4-(OCH 2 O)C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1732 
                 3-thiophenylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1733 
                 2-MeOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1734 
                 3,4-diClOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1735 
                 2,4-diClOC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1736 
                 2-ClC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1737 
                 H 2 NCH 2   
                 4-MeOC 6 H 4   
               
               
                 1738 
                 HOCH 2 NHCH 2 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1739 
                 Me 2 NCH 2   
                 4-MeOC 6 H 4   
               
               
                 1740 
                 PiperazinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1741 
                 4-Me-piperazinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1742 
                 4-HOCH 2 CH 2 -piperazinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1743 
                 PiperidinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1744 
                 4-NH 2 CH 2 -piperidinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1745 
                 CH 3 CH 2 NHCH 2   
                 4-MeOC 6 H 4   
               
               
                 1746 
                 ThiomorpholinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1747 
                 MorpholinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1748 
                 PyyrolidinylCH 2   
                 4-MeOC 6 H 4   
               
               
                 1749 
                 4-pyridylCH 2 NHCH 2   
                 4-MeOC 6 H 4   
               
               
                 1750 
                 4-CH 3 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1751 
                 4-CH 3 OCONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1752 
                 4-NH 2 CH 2 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1753 
                 4-Me 2 NCH 2 CONHC 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1754 
                 4-N 3 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1755 
                 4-NH 2 C 6 H 4 CH 2   
                 4-MeOC 6 H 4   
               
               
                 1756 
                 C 6 H 5 NH 
                 4-MeOC 6 H 4   
               
               
                 1757 
                 CH 3 CH 2 CH 2 NH 
                 4-MeOC 6 H 4   
               
               
                 1758 
                 4-NH 2 C 6 H 4 CH 2 NH 
                 4-MeOC 6 H 4   
               
               
                 1759 
                 4-pyridyCH 2 NH 
                 4-MeOC 6 H 4   
               
               
                 1760 
                 Methyl 
                 4-HOC 6 H 4   
               
               
                 1761 
                 H 
                 4-MeOC 6 H 4   
               
               
                 1762 
                 Methyl 
                 3-pyridyl 
               
               
                 1763 
                 Methyl 
                 4-pyridyl 
               
               
                 1764 
                 H 
                 4-pyridyl 
               
               
                 1765 
                 Methyl 
                 C 6 H 5   
               
               
                 1766 
                 Methyl 
                 4-MeSC 6 H 4   
               
               
                 1767 
                 Methyl 
                 4-MeSO 2 C 6 H 4   
               
               
                 1768 
                 Methyl 
                 4-Me 2 NC 6 H 4   
               
               
                 1769 
                 MorpholinylCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1770 
                 Me 2 NCH 2   
                 4-Me 2 NC 6 H 4   
               
               
                 1771 
                 Me 2 NCH 2   
                 4-(piperdinyl)C 6 H 4   
               
               
                 1772 
                 Me 2 NCH 2   
                 4-(morpholinyl)C 6 H 4   
               
               
                 1773 
                 Me 2 NCH 2   
                 4-CH 3 CH 2 OC 6 H 4   
               
               
                 1774 
                 Me 2 NCH 2   
                 4-CH 3 CH 2 CH 2 CH 2 C 6 H 4   
               
               
                 1775 
                 Me 2 NCH 2   
                 4-CH 3 CH 2 C 6 H 4   
               
               
                 1776 
                 Me 2 NCH 2   
                 4-CH 3 CH 2 CH 2 C 6 H 4