Abstract:
A precision densitometer for radiosensitive films and the like provides point-to-point scanning in which a laser source and collimated receiver are moved in tandem over the area of the film. The film may be supported only at its edges to remove scattering and interference caused by a glass support bed. Highly repeatable 25 μm resolution density measurements may be obtained.

Description:
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT 
       [0001]    -- 
       CROSS REFERENCE TO RELATED APPLICATION 
       [0002]    -- 
       BACKGROUND OF THE INVENTION 
       [0003]    The present invention relates to an optical densitometer for determining the density of radiosensitive films and in particular to a densitometer providing improved resolution and accuracy. 
         [0004]    Radiosensitive films are used for radiation dose measurement, for example, in medical radiotherapy in which ionizing radiation is used to treat malignant cells in cancer or the like. Such films, which provide high spatial resolution, are particularly useful in advanced radiation therapy systems, such as intensity modulated radiation therapy (IMRT) in which complex, fine beam patterns must be measured. Generally, the films are sensitive to ionizing radiation and can provide a spatial resolution as little as 25 micrometers and a wide dynamic range from a few milliGray to greater than 40 Gray. 
         [0005]    Radiochromic films are radiosensitive films that change color on exposure to ionizing radiation without the need for chemical or other processing. While such films can be used for qualitative dose measurement, normally they are scanned, for example, with a flatbed optical scanning mechanism and the measured film density, that is light absorption caused by the exposed film pigment, is applied to a calibration curve to yield a quantitative measurement of received radiation dose. The resulting scans may be further processed, for example, to extract isodose curves or other quantitative information. 
         [0006]    While radiosensitive films provide advantages over ionization detectors and solid-state detectors in terms of spatial resolution and dynamic range, obtaining consistent quantitative results with radiosensitive films can be difficult. 
       SUMMARY OF THE INVENTION 
       [0007]    The present inventors have identified a number of significant sources of inaccuracy in the quantitative scanning of radiosensitive films, including scattering from off-axis, incident light from broad area illumination, internal scattering within the charge-coupled device light sensors, and scattering and interference effects introduced by the supporting glass bed. In addition, the inventors have noted that the characteristics of the film&#39;s emulsion are changed by scanning-induced heating of the film and additional variations may be introduced by spectral mis-match between the light source illuminating the film and the particular film chemistry. 
         [0008]    The present invention addresses these issues of scattering and interference by providing a “point-to-point” scanning mechanism operating on the film as it is suspended in free space. The point-to-point scan uses a moving point light source and point detector to largely eliminate scatter from off-axis light and scatter within a sensor array. Suspension of the film eliminates the scattering and interference from the glass bed. By moving the light source and detector, consistent illumination and detection is obtained over the entire scan area, reducing sensitivity in the results to film placement and orientation. Focused and hence more efficient illumination together with cooling significantly reduces changes in the emulsion caused by heating. In sonic embodiments a variable wavelength or dual wavelength laser source may be used to accommodate film chemistry variations and to provide improved calibration density measurements of the film to radiation dose. 
         [0009]    Specifically, the present invention provides a film densitometer having a film support holding a film along a scanning plane. A scanning mechanism supports a light source and a light detector so that the light source and light detector remain aligned along a common axis substantially perpendicular to a scanning plane on opposite sides of the scanning plane while the scanning mechanism moves the light source and a light over the film according to electrical movement signals. A controller generates movement signals to move the light source and light detector among a set of different locations on each side of a film as held in the support while illuminating the film with the light source and to detect transmitted light through the film at the set of different locations with the light detector to provide a detection signal at each location. A set of density values based on the detection signal are then output for the locations. The light source may be a laser emitting a focused beam along the common axis and the light detector may be a photo detector selectively receiving light primarily along the common axis. 
         [0010]    It is thus a feature of at least one embodiment of the invention to reduce measurement variations related to film position and orientation in the scanner. By moving the light source and detector over an area as opposed to providing broad area illumination or broad area detection, more uniform detection fields may be implemented. 
         [0011]    The laser may provide a substantially circular illumination spot on the film as held in the support, for example, less than 100 μm in diameter. 
         [0012]    It is a feature of at least one embodiment of the invention to greatly reduce scatter from off-axis incident illumination by illuminating only on the portion of the film being measured. 
         [0013]    Similarly, the light detector may provide a substantially circular field of view on the film of less than 100 μm in diameter, for example, by focusing or collimation. 
         [0014]    It is a feature of at least one embodiment of the invention to further reduce scattering by blocking off-axis light scattered by the film itself. 
         [0015]    The controller may apply a calibration function to the detection signals to provide the density values representing radiation dose. 
         [0016]    It is thus a feature of at least one embodiment of the invention to provide a quantitative dose measurement suitable for quality assurance or calibration of radiation equipment where high-resolution measurement must be obtained. 
         [0017]    The output can provide one or more of an image representing density values as image pixels having values corresponding to the detection signals and coordinates corresponding to the different locations and isodose curves of the density values. 
         [0018]    It is thus a feature of at least one embodiment of the invention to provide for standard output measurements familiar to those measuring radiation dose. 
         [0019]    The scanning mechanism may include motors for moving the light source and light detector in two perpendicular directions and position sensors providing position signals indicating position of the light source and light detector in the two perpendicular directions, and the scanning mechanism may provide a feedback control of the motors according to a difference between the position signals and the electrical movement signals. 
         [0020]    It is thus a feature of at least one embodiment of the invention to provide a mechanism that allows point-to-point measurement at high throughput speeds with sufficient accuracy. 
         [0021]    The laser may have a wavelength substantially equal to 635 nm. 
         [0022]    It is thus a feature of at least one embodiment of the invention to provide an illumination source well adapted for radiochromic films. 
         [0023]    The laser may provide an output wavelength according to a control signal and the controller may execute the stored program to adjust the output wavelength of the laser according to a characteristic of a film held in the support. 
         [0024]    It is thus a feature of at least one embodiment of the invention to permit tuning of the laser for maximum sensitivity of measurement, for example, at a peak sensitivity range of the film. 
         [0025]    The laser may provide for at least two output was (for example using a single or multiple lasing elements) according to a control signal and the controller may execute the stored program to change the output wavelength of the laser at each of the set of locations to provide for detection signals for each of at least two wavelengths. 
         [0026]    It is thus a feature of at least one embodiment of the invention to provide for multiple wavelength dimensions in the measurement process such as allows improved calibration of density to dose. 
         [0027]    The light detector may be a photo diode. 
         [0028]    It is thus a feature of at least one embodiment of the invention to eliminate internal scattering present in CCD and similar array devices. 
         [0029]    The light detector may be collimated along the axis by a collimation aperture. 
         [0030]    It is thus a feature of at least one embodiment of the invention to provide a simple method of controlling a field of view of the light detector that rejects off-axis light. 
         [0031]    The scanning mechanism may provide at least one tray element supporting the film at edges of the film so that a center of the film is removed from contact with any support material. 
         [0032]    It is thus a feature of at least one object of the invention to eliminate refraction and scattering that occur in glass support beds often used to support radiosensitive film for scanning. 
         [0033]    The densitometer may include a light-opaque housing surrounding the scanning mechanism to block light external to the opaque shroud from the light detector. 
         [0034]    It is thus a feature of at least one embodiment of the invention to eliminate the effect of variations in external light sources in the measurement of density. 
         [0035]    The housing may include air-cooling elements for controlling a temperature within the housing to a substantially constant temperature. 
         [0036]    It is thus a feature of at least one embodiment of the invention to eliminate or reduce effects of varying temperature and heating by the scanner itself in changing the measured density of the film. 
         [0037]    These particular features and advantages may apply to only some embodiments falling within the claims and thus do not define the scope of the invention. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0038]      FIG. 1  is a simplified perspective representation of a radiotherapy suite showing an example radiotherapy machine exposing radiochromic film in a phantom and showing a densitometer according to the present invention having a tray for receiving the film and insertion into a housing for scanning, the densitometer including a computer for processing the scanned data; 
           [0039]      FIG. 2  is a perspective partial phantom view of the housing of the densitometer of  FIG. 1  showing an internal scanning mechanism and the positioning of the tray along a scanning plane between a movable light source and detector (the latter not visible in  FIG. 2 ); 
           [0040]      FIG. 3  is a fragmentary side elevational view and expanded detail of the light source, detector and tray of  FIG. 2 ; 
           [0041]      FIG. 4  is a set of simplified calibration curves for radiochromic film plotting density versus wavelength for different radiation exposure levels; 
           [0042]      FIG. 5  is an example output of the densitometer of  FIG. 1  as displayed on the computer screen showing a density image, isodose curves, and a quantitative longitudinal plot; and 
           [0043]      FIG. 6  is a perspective view and enlarged fragmentary view of the tray of  FIG. 1 . 
       
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT 
       [0044]    Referring now to  FIG. 1 , a radiotherapy treatment suite  10 , in which the present invention may be beneficially employed, may provide for a radiation therapy machine  12  having a radiation head  14  directing radiation toward a patient table  16 . The radiation therapy machine  12  may, for example, be an intensity modulated radiation therapy machine (IMRT) such as a Tomotherapy® radiotherapy system manufactured by Accuray or the like providing complex modulated radiation beams at a plurality of angles. A radiation phantom  18  may be positioned on the table  16 , for example, for quality assurance or calibration of the radiation therapy machine  12 . The radiation phantom  18  may provide a structure that mimics tissue of a similarly situated human patient, for example, using a water equivalent plastic such as Lucite™. 
         [0045]    Radiation received by the phantom  18  may be monitored through a set of radiosensitive film elements  20  inserted into the phantom  18 , for example, comprised of squares of radiochromic film such as GAFCHROMIC® EBT radiochromic film. 
         [0046]    After removal from the phantom  18 , the film elements  20  may be arranged on a tray  22  subsequently inserted into scanner  24  of a densitometer  26 . Generally the scanner  24  provides a light-opaque housing  25  shielding internal elements of the scanner (as will be described below) from external light. The housing  25  may be constructed from black ABS plastic, for example. The tray  22  may be installed through a slot  28  in the housing  25 , the slot minimizing the admission of light from external sources into the housing  25  where that light may interfere with the densitometry measurements. 
         [0047]    The scanner  24  may communicate with a standard desktop computer  30 , for example, providing a graphic display  32  associated with a processing unit  34  including one or more computer processors  36  and associated computer memory  38 . The computer memory  38 , as is understood in the art, may hold a stored program  40  implementing various features of the present invention as will be described below. The processing unit  34  may further communicate with user input elements  42 , for example a mouse and keyboard, according to techniques well understood in the art. 
         [0048]    Referring now to  FIG. 2 , the scanner  24  holds an x-y carriage  44  having lateral rails  46  on which a moving frame  48  may slide as driven by motor  52   a  to move in translation along a y-axis as indicated by arrow  50 . The moving frame  48  in turn provides upper and lower transverse rails  54  that may hold, respectively, a light source  56  and light detector  58  (not visible in  FIG. 2 ) above and below the scanning tray  22  when the scanning tray  22  is positioned generally horizontally within the scanner  24  to extend along a scanning plane  57 . 
         [0049]    The moving frame  48  holds a motor  52   b  moving the light source  56  and light detector  58  in unison in a direction parallel to an x-axis as indicated by arrow  59 . Motors  52  may, for example, be STM NEMA 17 form factors. 
         [0050]    The housing  25  may include one or more cooling fans  61 , for example, thermostatically controlled to maintain a constant temperature within the housing  25  against heating of the air inside the housing  25  by the motors  52  and the light source  56 . 
         [0051]    Referring now also to  FIG. 3 , motor  52   b  may provide a torque tube  60  extending generally vertically downward from the motor  52   b  as depicted and attached to two co-rotating timing belt pulleys  62   a  and  62   b.  The timing belt pulleys  62   a  and  62   b  communicate through timing belts  64   a  and  64   b  extending along the x-axis, respectively, to attach to carriage slides  66   a  and  66   b,  the latter movable along respective transverse rails  54  in the x-direction. 
         [0052]    Carriage slide  66   a  supports light source  56  which may be a laser directing a focused beam  70  downward to the tray  22  along axis  81  and generally perpendicular to the scanning plane  57  in parallel to the z-axis. The beam  70  is focused in a circular spot  71  on a surface of the film element  20  held in the tray  22 . The light passes through the film element  20  to be received by the light detector  58 . A suitable laser for one embodiment of the invention is the Edmund Optics LDM 635 nm laser diode. 
         [0053]    The illuminated spot  71  on the film element  20  will typically be a circular focal point of less than 50 μm in diameter and desirably as little as 25 μm in diameter. 
         [0054]    Light detector  58  may be an upwardly exposed photodiode  72  (for example of a type commercially available from Hamamatsu) and may be encased in a collimating housing  74  having an aperture  76  that generally rejects off-axis, scattered light  78  from the laser beam  70  as scattered by the film element  20  and deviating from axis  81 . Aperture  76  is preferably sized to be approximately the size of a focal spot of the beam  70  on the film element  20 . Ambient light  80  is generally reduced or eliminated by the opaque housing  25  discussed above and rejected to the extent that it is also off-axis. 
         [0055]    The signal from the photodiode may be received by a pre-processing circuit  75  including a logarithmic amplifier (MAXIM4206KIT) applying a logarithm to the received signal and then converting the received signal into a digital word by a 12-bit analog-to-digital converter (Keithley KUSB-3100). The digital word may be communicated to the processing unit  34  for processing as will be described. 
         [0056]    It will be understood that the stiffness of the torque tube  60  provides unison motion of the carriage slides  66   a  and  66   b  so that the light source  56  and light detector  58  remain substantially aligned along the common axis  81  with transverse movement as indicated by arrow  59 . The light source  56  and light detector  58  may be moved in this alignment over the entire area of the tray  22  in a raster scan through successive or simultaneous movement along the x- and y-axes through motors  52   a  and  52   b  while maintaining alignment above and below the tray  22  along the axis  81 . 
         [0057]    Referring to  FIGS. 3 and 6 , the film element  20  as held in the tray  22  is supported substantially only at its edges by frame lips  82  as centered over a central aperture  90  by frame walls  92  which together with the frame lips  82  and aperture  90  provide a pocket  94  for receiving one film element  20 . In this way, a center region of the film element  20 , being a region of interest for densitometry, is removed from any supporting structure that might cause aberration scattering or distortions as may occur with the supporting glass bed in a standard flatbed scanner. 
         [0058]    Multiple pockets  94  may be tiled over the surface of the tray  22  and may be given different dimensions for holding different sizes of film elements  20 . The tray  22  may be generally supported at its edges away from the pockets  94  on a pair of slide rails or a conveyor mechanism (not shown) of the type well known in the art. 
         [0059]    Referring again to  FIGS. 2 and 3 , a linear position marker  96 , for example a periodically magnetized strip of material, may extend along at least one of each of the rails  46  and  54  to be sensed by a corresponding sensor reader  98 , for example a magnetic pickup head, to provide precise relative position sensing of at least one of carriage slides  66   a  and  66   b  in the transverse direction and of the moving frame  48  in the longitudinal direction. The position marker  96  and sensor reader  98  may be coupled with limit switches  100  which provide absolute reference positions of the carriage slides  66   a  or  66   b  and moving frame  48  so that absolute position may be derived (for example by homing the carriage slides  66   a  or  66   b  or moving frame  48  against the limit switches  100 ). Signals from each of the sensor readers  98  are received by a feedback controller  102  conveniently positioned within the housing  25  but alternatively implemented by the processing unit  34  which may control motors  52   a  and  52   b  to provide for 25 μm accurate positioning in the x-y plane. As is understood in the art, the feedback controller accepts a motion command and compares that to a sensed position to produce an error value that is used to drive the motors  52 . The accuracy of such a feedback system is limited only by the accuracy of the position sensor (linear position marker  96  and sensor reader  98 ) which may be 25 μm in one embodiment. 
         [0060]    Referring now to  FIGS. 3 and 4 , the program  40  of the processing unit  34  may hold a set of calibration curves  106 , each curve associated with a different radiation dose level, and each curve describing a density of the film element  20  in different wavelength bands (lambda) when the film is exposed to the associated dose level. The calibration curves  106  may be used to convert received signals from the scanner  24  indicating density into a quantitative dose value indicating radiation dose. In one embodiment, the light source  56  may be a tunable laser whose wavelength (lambda) may be adjusted as indicated by arrow  108  to provide for a wavelength maximum density sensitivity, for example, as indicated aligned with peaks in each of the curves  106 . One suitable laser wavelength may be 635 nm. 
         [0061]    During operation of the scanner  24 , processing unit  34  will operate as a controller to move the axis  81 , for example, in a raster scan pattern over the area of the tray  22 . At regular intervals, for example 25 μm intervals, a signal from the light detector  58  may be acquired, for example, by the 12 bit A/D converter, and stored together with position coordinates of the axis  81  in the x-y plane. By moving the light source  56  and light detector  58 , uniformity of measurement can be ensured over an entire area of the scan largely eliminating the variations which occur when an area illuminator is used for this purpose. Reducing the focal spot area greatly reduces the off-axis, scattered light  78  both from the detected region and regions outside of the detected region. Upon completion of the scan, the density values may be converted to dose values and an output provided, for example, on the display  32 . 
         [0062]    Referring now to  FIG. 5 , generally the display will provide an image  110  having multiple pixels  112  whose color or gray value will be proportional to a calculated dose at a location in the scan corresponding to the coordinates of the pixel  112 . Thus an image is formed that looks substantially like the film element  20 . Because each pixel  112  is associated with a numeric value, isodose lines  114  may be calculated and superimposed on the image  110  according to techniques well known in the art. In addition quantitative values  116 , for example, displayed as the vertical axis of a plot dose along a given transverse slice (x-axis) through the image  110  may be provided for precise understanding of dose levels. It will be appreciated that other standard manipulations of this information may be provided including average dose within a predetermined area determining peak dose and the like. 
         [0063]    Certain terminology is used herein for purposes of reference only, and thus is not intended to be limiting. For example, terms such as “upper”, “lower”, “above”, and “below” refer to directions in the drawings to which reference is made. Terms such as “front”, “back”, “rear”, “bottom” and “side”, describe the orientation of portions of the component within a consistent but arbitrary frame of reference which is made clear by reference to the text and the associated drawings describing the component under discussion. Such terminology may include the words specifically mentioned above, derivatives thereof, and words of similar import. Similarly, the terms “first”, “second” and other such numerical terms referring to structures do not imply a sequence or order unless clearly indicated by the context. 
         [0064]    When introducing elements or features of the present disclosure and the exemplary embodiments, the articles “a”, “an”, “the” and “said” are intended to mean that there are one or more of such elements or features. The terms “comprising”, “including” and “having” are intended to be inclusive and mean that there may be additional elements or features other than those specifically noted. It is further to be understood that the method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order discussed or illustrated, unless specifically identified as an order of performance. It is also to be understood that additional or alternative steps may be employed. 
         [0065]    References to “controller” “processor” “circuit” can be understood to include one or more such devices that can communicate in a stand-alone and/or a distributed environment(s), and can thus be configured to communicate via wired or wireless communications with other processors, where such one or more processor can be configured to operate on one or more processor-controlled devices that can be similar or different devices. That is to say, unless specifically noted, the location of these devices and how the functionality is distributed is not critical. Furthermore, references to memory, unless otherwise specified, can include one or more processor-readable and accessible memory elements and/or components that can be internal to the processor-controlled device, external to the processor-controlled device, and can be accessed via a wired or wireless network. 
         [0066]    It is specifically intended that the present invention not be limited to the embodiments and illustrations contained herein and the claims should be understood to include modified forms of those embodiments including portions of the embodiments and combinations of elements of different embodiments as come within the scope of the following claims. All of the publications described herein, including patents and non-patent publications, are hereby incorporated herein by reference in their entireties.