Abstract:
This invention relates to molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.

Description:
This application claims the benefit of U.S. Provisional Application No. 60/055,944 filed Aug. 18, 1997 and U.S. Provisional Application No. 60/068,335 filed on Dec. 19, 1997. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates to novel molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF), pharmaceutical preparations containing them and to their use as pharmaceutical agents. In particular the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. 
     BACKGROUND OF THE INVENTION 
     There is now a body of evidence that metalloproteinases (MP) are important in the uncontrolled breakdown of connective tissue, including proteoglycan and collagen, leading to resorption of the extracellular matrix. This is a feature of many pathological conditions, such as rheumatoid and osteoarthritis, corneal, epidermal or gastric ulceration; tumor metastasis or invasion; periodontal disease and bone disease. Normally these catabolic enzymes are tightly regulated at the level of their synthesis as well as at their level of extracellular activity through the action of specific inhibitors, such as alpha-2-macroglobulins and TIMP (tissue inhibitor of metalloproteinase), which form inactive complexes with the MP&#39;s. 
     Osteo- and Rheumatoid Arthritis (OA and RA respectively) are destructive diseases of articular cartilage characterized by localized erosion of the cartilage surface. Findings have shown that articular cartilage from the femoral heads of patients with OA, for example, had a reduced incorporation of radiolabeled sulfate over controls, suggesting that there must be an enhanced rate of cartilage degradation in OA (Mankin et al. J. Bone Joint Surg. 52A, 1970, 424-434). There are four classes of protein degradative enzymes in mammalian cells: serine, cysteine, aspartic and metalloproteinases. The available evidence supports that it is the metalloproteinases which are responsible for the degradation of the extracellular matrix of articullar cartilage in OA and RA. Increased activities of collagenases and stromelysin have been found in OA cartilage and the activity correlates with severity of the lesion (Mankin et al. Arthritis Rheum. 21, 1978, 761-766, Woessner et al. Arthritis Rheum. 26, 1983, 63-68 and Ibid. 27, 1984, 305-312). In addition, aggrecanase (a newly identified metalloproteinase enzymatic activity) has been identified that provides the specific cleavage product of proteoglycan, found in RA and OA patients (Lohmander L. S. et al. Arthritis Rheum. 36, 1993, 1214-22). 
     Therefore metalloproteinases (MP) have been implicated as the key enzymes in the destruction of mammalian cartilage and bone. It can be expected that the pathogenesis of such diseases can be modified in a beneficial manner by the administration of MP inhibitors, and many compounds have been suggested for this purpose (see Wahl et al. Ann. Rep. Med. Chem. 25, 175-184, AP, San Diego, 1990). 
     This invention describes novel molecules that inhibit aggrecanase and other metalloproteinases. These novel molecules are provided as cartilage protecting therapeutics. The inhibition of aggrecanase and other metalloproteinases by these novel molecules prevent the degradation of cartilage by these enzymes, thereby alleviating the pathological conditions of osteo- and rheumatoid arthritis. 
     Tumor necrosis factor (TNF) is a cell associated cytokine that is processed from a 26 kD precursor form to a 17 kD active form. TNF has been shown to be a primary mediator in humans and in animals, of inflammation, fever, and acute phase responses, similar to those observed during acute infection and shock. Excess TNF has been shown to be lethal. There is now considerable evidence that blocking the effects of TNF with specific antibodies can be beneficial in a variety of circumstances including autoimmune diseases such as rheumatoid arthritis (Feldman et al, Lancet, 1994, 344, 1105) and non-insulin dependent diabetes melitus. (Lohmander L.S. et al. Arthritis Rheum. 36, 1993, 1214-22) and Crohn&#39;s disease (Macdonald T. et al. Clin. Exp. Immunol. 81, 1990, 301). 
     Compounds which inhibit the production of TNF are therefore of therapeutic importance for the treatment of inflammatory disorders. Recently it has been shown that a matrix metalloproteinase or family of metalloproteinases, hereafter known as TNF-convertases (TNF-C), as well as other MP&#39;s are capable of cleaving TNF from its inactive to active form (Gearing et al Nature, 1994, 370, 555). This invention describes novel molecules that inhibit this conversion and hence the secretion of active TNF-α from cells. These novel molecules provide a means of mechanism based therapeutic intervention for diseases including but not restricted to septic shock, haemodynamic shock, sepsis syndrome, post ischaemic reperfusion injury, malaria, Crohn&#39;s disease, inflammatory bowel diseases, mycobacterial infection, meningitis, psoriasis, congestive heart failure, fibrotic diseases, cachexia, graft rejection, cancer, diseases involving angiogenesis, autoimmune diseases, skin inflammatory diseases, rheumatoid arthritis, multiple sclerosis, radiation damage, hyperoxic alveolar injury, HIV and non-insulin dependent diabetes melitus. 
     Since excessive TNF production has been noted in several disease conditions also characterized by MMP-mediated tissue degradation, compounds which inhibit both MMPs and TNF production may also have a particular advantage in diseases where both mechanisms are involved. 
     There are several patents which disclose hydroxamate and carboxylate based MMP inhibitors. 
     PCT International Publication No. WO 92/213260 describes N-carboxyalkylpeptidyl compounds of general formula:                           
     wherein AA is an amino acid, as inhibitors of matrix metallproteinase mediated diseases. 
     PCT International Publication No. WO 90/05716 discloses hydroxamic acid based collagenase inhibitors having the general formula:                           
     PCT International Publication No. WO 92/13831 describes related hydroxamic acids having collagenase inhibiting activity with the general formula:                           
     PCT International Publication No. WO 94/02446 discloses metalloproteinase inhibitors which are natural amino acid derivatives of general formula:                           
     WO95/09841 describes compounds that are hydroxamic acid derivatives and are inhibitors of cytokine production. 
     European Patent Application Publication No. 574,758 A1, discloses hydroxamic acid derivatives as collagenase inhibitors having the general formula:                           
     GB 2 268 934 A and WO 94/24140 claim hydroxamate inhibitors of MMPs as inhibitors of TNF production. 
     The compounds of the current invention act as inhibitors of MPs, in particular aggrecanase and TNF-C, thereby preventing cartilage loss and destruction and inflammatory disorders involving TNF. The hydroxamic and carboxylic acids and derivatives contain a cyclic peptide mimic attached to a succinate peptide mimic, and thus the inhibitors are non-peptide in nature. A selection of these molecules are water soluble and are orally bioavailable. 
     SUMMARY OF THE INVENTION 
     This invention provides novel hydroxamic acids and carboxylic acids and derivatives thereof of formula (I) (described below) which are useful as inhibitors of metalloproteinases, such as aggrecanase and TNF-C. The present invention also includes pharmaceutical compositions comprising such compounds of formula (I) and methods of using such compounds for the treatment of arthritis and other inflammatory disorders as described previously, in a patient. 
     Also included in the present invention are pharmaceutical kits comprising one or more containers containing pharmaceutical dosage units comprising a compound of formula (I), for the treatment of arthritis and other inflammatory disorders as described previously. 
     The present invention also includes methods of inhibiting metalloproteinases, such as aggrecanase and TNF-C, and for the treatment of arthritis by administering a compound of formula (I) in combination with one or more second therapeutic agents selected from other inhibitors of metalloproteinases, such as aggrecanase and TNF-C and/or therapeutic agents for the treatment of arthritis and inflammation. 
     DETAILED DESCRIPTION OF THE INVENTION 
     This invention provides novel hydroxamic acids and carboxylic acids and derivatives thereof of formula (I) (described below) which are useful as inhibitors of metalloproteinases, such as aggrecanase and TNF-C. The present invention also includes pharmaceutical compositions comprising such compounds of formula (I) and methods of using such compounds for the treatment of arthritis and other inflammatory disorders as described previously, in a patient. 
     Also included in the present invention are pharmaceutical kits comprising one or more containers containing pharmaceutical dosage units comprising a compound of formula (I), for the treatment of arthritis and other inflammatory disorders as described previously. 
     The present invention also includes methods of inhibiting metalloproteinases, such as aggrecanase and tumor necrosis factor alpha, and for the treatment of arthritis by administering a compound of formula (I) in combination with one or more second therapeutic agents selected from other inhibitors of metalloproteinases, such as aggrecanase and tumor necrosis factor alpha and/or therapeutic agents for the treatment of arthritis and inflammation. 
     DEFINITIONS 
     The compounds herein described may have asymmetric centers. Compounds of the present invention containing an asymmetrically substituted atom may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. Many geometric isomers of olefins, C═N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention. Cis and trans geometric isomers of the compounds of the present invention are described and may be isolated as a mixture of isomers or as separated isomeric forms. All chiral, diastereomeric, racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomeric form is specifically indicated. 
     The term “substituted,” as used herein, means that any one or more hydrogens on the designated atom is replaced with a selection from the indicated group, provided that the designated atom&#39;s normal valency is not exceeded, and that the substitution results in a stable compound. When a substitent is keto (i.e., ═O), then 2 hydrogens on the atom are replaced. 
     When any variable (e.g., R b ) occurs more than one time in any constituent or formula for a compound, its definition at each occurrence is independent of its definition at every other occurrence. Thus, for example, if a group is shown to be substituted with 0-2 R 6 , then said group may optionally be substituted with up to two R 6  groups and R 6  at each occurrence is selected independently from the definition of R 6 . Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. 
     When a bond to a substituent is shown to cross a bond connecting two atoms in a ring, then such substituent may be bonded to any atom on the ring. When a substituent is listed without indicating the atom via which such substituent is bonded to the rest of the compound of a given formula, then such substituent may be bonded via any atom in such substituent. Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. 
     As used herein, “H” is intended to include substitutions with deuterium or tritium. Where “H” is not indicated but is part of a bond then substitutions with deuterium or tritium are also intentded. 
     As used herein, “C 1-10  alkyl” or “C 1-10  alkylene” is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, examples of which include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, t-butyl, pentyl, and hexyl; 
     “Alkenyl” or “alkenylene” is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl, and the like. 
     “Alkynyl” or “alkynylene” is intended to include hydrocarbon chains of either a straight or branched configuration and one or more carbon-carbon triple bonds which may occur in any stable point along the chain, such as ethynyl, propynyl, and the like. 
     As used herein, “aryl” or “aromatic residue” is intended to include phenyl or naphthyl as well as commonly referred to “heterocycle” or “heteroaryl” or “heterocyclic” compounds. 
     As used herein the term “alkylaryl” represents an aryl group attached through an alkyl bridge. 
     “Halo” or “halogen” as used herein refers to fluoro, chloro, bromo, and iodo; and “counterion” is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, sulfate, and the like. 
     As used herein, “carbocycle” or “carbocyclic residue” is intended to mean any stable 3- to 7-membered monocyclic or bicyclic or 7- to 13-membered bicyclic or tricyclic, any of which may be saturated, partially unsaturated, or aromatic. Examples of such carbocycles include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, cyclooctyl, [3.3.0]bicyclooctane, [4.3.0]bicyclononane, [4.4.0]bicyclodecane (decalin), [2.2.2]bicyclooctane, fluorenyl, phenyl, naphthyl, indanyl, adamantyl, or tetrahydronaphthyl (tetralin). 
     As used herein, the term “heterocycle”,or “heterocyclic system” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 14-membered bicyclic heterocyclic ring which is saturated partially unsaturated or unsaturated (aromatic), and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The nitrogen and sulfur heteroatoms may optionally be oxidized. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. If specifically noted, a nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and O atoms in the heterocycle exceeds 1, then these heteroatoms are not adjacent to one another. It is preferred that the total number of S and O atoms in the heterocycle is not more than 1. 
     As used herein, the term “aromatic heterocyclic system” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 14-membered bicyclic heterocyclic aromatic ring which consists of carbon atoms and from 1 to 4 heterotams independently selected from the group consisting of N, O and S. It is preferred that the total number of S and O atoms in the aromatic heterocycle is not more than 1. 
     Examples of heterocycles include, but are not limited to, 1H-indazole, 2-pyrrolidonyl, 2H,6H-1,5,2-dithiazinyl, 2H-pyrrolyl, 3H-indolyl, 4-piperidonyl, 4aH-carbazole, 4H-quinolizinyl, 6H-1,2,5-thiadiazinyl, acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazalonyl, carbazolyl, 4aH-carbazolyl, b-carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H,6H-1,5,2-dithiazinyl, dihydrofuro[2,3-b]tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, morpholinyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxazolidinylperimidinyl, phenanthridinyl, phenanthrolinyl, phenarsazinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, piperidonyl, 4-piperidonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolinyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, carbolinyl, tetrahydrofuranyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, triazinyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, xanthenyl. Preferred heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, indolyl, benzimidazolyl, 1H-indazolyl, oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl, or isatinoyl. Also included are fused ring and spiro compounds containing, for example, the above heterocycles. 
     The term “amino acid” as used herein means an organic compound containing both a basic amino group and an acidic carboxyl group. Included within this term are natural amino acids (e.g., L-amino acids), modified and unusual amino acids (e.g., D-amino acids), as well as amino acids which are known to occur biologically in free or combined form but usually do not occur in proteins. Included within this term are modified and unusual amino acids, such as those disclosed in, for example, Roberts and Vellaccio (1983)  The Peptides , 5: 342-429, the teaching of which is hereby incorporated by reference. Natural protein occurring amino acids include, but are not limited to, alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tyrosine, tyrosine, tryptophan, proline, and valine. Natural non-protein amino acids include, but are not limited to arginosuccinic acid, citrulline, cysteine sulfinic acid, 3,4-dihydroxyphenylalanine, homocysteine, homoserine, ornithine, 3-monoiodotyrosine, 3,5-diiodotryosine, 3,5,5′-triiodothyronine, and 3,3′,5,5′-tetraiodothyronine. Modified or unusual amino acids which can be used to practice the invention include, but are not limited to, D-amino acids, hydroxylysine, 4-hydroxyproline, an N-Cbz-protected amino acid, 2,4-diaminobutyric acid, homoarginine, norleucine, N-methylaminobutyric acid, naphthylalanine, phenylglycine, β-phenylproline, tert-leucine, 4-aminocyclohexylalanine, N-methyl-norleucine, 3,4-dehydroproline, N,N-dimethylaminoglycine, N-methylaminoglycine, 4-aminopiperidine-4-carboxylic acid, 6-aminocaproic acid, trans-4-(aminomethyl)-cyclohexanecarboxylic acid, 2-, 3-, and 4-(aminomethyl)-benzoic acid, 1-aminocyclopentanecarboxylic acid, 1-aminocyclopropanecarboxylic acid, and 2-benzyl-5-aminopentanoic acid. 
     The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. 
     As used herein, “pharmaceutically acceptable salts” refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, and the like. 
     The pharmaceutically acceptable salts of the present invention can be synthesized from the parent. compound which contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in  Remington&#39;s Pharmaceutical Sciences , 17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418, the disclosure of which is hereby incorporated by reference. 
     “Prodrugs” and “prodrug derivatives” are intended to include any covalently bonded carriers which release the active parent drug according to formula (I) in vivo when such prodrug is administered to a mammalian subject. Prodrugs of a compound of formula (I) are prepared by modifying functional groups present in the compound in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compound. Prodrugs include compounds of formula (I) wherein a hydroxy, amino, or sulfhydryl group is bonded to any group that, when the prodrug or compound of formula (I) is administered to a mammalian subject, cleaves to form a free hydroxyl, free amino, or free sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of formula (I), and the like. 
     “Stable compound” and “stable structure” are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. 
     [1] There is provided by this invention a compound of the formula (I):                           
     or a pharmaceutically acceptable salt form or a steroisomer thereof, wherein: 
     R 1  is selected from: 
     —CO 2 H, —C(O)NHOH, —C(O)NHOR 7 , —SH, —CH 2 CO 2 R 7 , —COR 7 , —N(OH)COR 7 , —SN 2 H 2 R 7 , —SONHR 7 , —CH 2 CO 2 H, —PO(OH) 2 , —PO(OH)NHR 7 , —CH 2 SH, —C(O)NHOR 7 , —CO 2 R 7 , and common prodrug derivatives; 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 4  is selected from: 
     hydrogen, (C 1 -C 5 )alkyl, (C 1 -C 5 )alkyl-aryl, 
     R 5  and R 6  are independently selected from: 
      U—X—Y—Z—U a —X a —Y a —Z a   
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 7  is selected from: C 1 -C 10  alkyl, alkylaryl, and common prodrug derivatives 
     A is selected from: 
     SO 2 , SO, CHOH; 
     E is (CR 8 R 9 ) m —W—(CR 8 R 9 ) n , 
     wherein W can be absent or selected from: 
     CH 2 , CO, O, S(O) m  and NR 10 , 
     m is 0-2, 
     n is 0-2; 
     with the proviso that when W is O, S or NR 10  then m must not be 0; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, 
     C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O)m. 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH, or N. 
     with no more than two N in the cycle. 
     [2] The present invention includes compounds of formula (I) wherein: 
     R 1  is selected from: —CO 2 H, —C(O)NHOH, —C(O)NHOR 7 , —SH, —CH 2 CO 2 R 7 , —COR 7 , —N(OH)COR 7 , —SN 2 H 2 R 7 , —SONHR 7 , —CH 2 CO 2 H, —PO(OH) 2 , —PO(OH)NHR 7 , —CH 2 SH, —C(O)NHOR 7 , —CO 2 R 7 , and common prodrug derivatives; 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
      U—X—Y—Z—U a —X a —Y a —Z a   
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 4  is selected from: 
     hydrogen, 
     R 5  and R 6  are independently selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 7  is selected from: C 1 -C 10  alkyl, alkylaryl, and common prodrug derivatives 
     A is selected from: 
     SO 2 , SO, CHOH; 
     E is (CR 8 R 9 ) m —W—(CR 8 R 9 ) n , 
     wherein W can be absent or selected from: 
     CH 2 , CO, O, S(O) m  and NR 10 , 
     m is 0-2, 
     n is 0-2; 
     with the proviso that when w is O, S or NR 10 then    
     m must not be 0; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, 
     C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O)m. 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH, or N. 
     with no more than two N in the cycle. 
     [3] The present invention includes preferred compounds of formula (I) wherein: 
     R 1  is selected from: 
     —CO 2 H, —C(O)NHOH, —C(O)NHOR 7 , —SH, —CH 2 CO 2 R 7 , 
     and common prodrug derivatives; 
     R 2  is selected from the formula: 
      U—X—Y—Z—U a —X a —Y a —Z a   
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 4  is selected from: 
     hydrogen, 
     R 5  and R 6  are independently selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 7  is selected from: C 1 -C 10  alkyl, alkylaryl, and common prodrug derivatives 
     A is selected from: 
     SO 2 , SO, CHOH; 
     E is (CR 8 R 9 ) m —W—(CR 8 R 9 ) n , 
     wherein W can be absent or selected from: 
     CH 2 , CO, O, S(O) m  and NR 10 , 
     m is 0-2, 
     n is 0-2; 
     with the proviso that when W is O, S or NR 10  then 
     m must not be 0; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b ; 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, 
     C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O) m . 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH,or N. 
     with no more than two N in the cycle. 
     [4] There is provided by this invention preferred compounds of the formula (II):                           
     or a pharmaceutically acceptable salt form or a steroisomer thereof, wherein: 
     R 1  is selected from: 
     —CO 2 H, —C(O)NHOH, —C(O)NHOR 7 , —SH, —CH 2 CO 2 R 7 , 
     and common prodrug derivatives; 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
      U—X—Y—Z—U a —X a —Y a —Z a   
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(OO, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 5  is selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 7  is selected from: C 1 -C 10  alkyl, alkylaryl, and common prodrug derivatives 
     E is (CR 8 R 9 ) m —W—(CR 8 R 9 ) n , 
     wherein W can be absent or selected from: 
     CH 2 , CO, O, S(O) m  and NR 10 , 
     m is 0-2, 
     n is 0-2; 
     with the proviso that when W is O, S or NR 10  then 
     m must not be 0; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, 
     C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O) m . 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH, or N. 
     with no more than two N in the cycle. 
     [5] Preferred compounds of the present invention include compounds of formula (II) wherein: 
     R 1  is selected from: 
     —C(O)NHOH, 
     and common prodrug derivatives; 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , C 1 , F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3, CF   2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 5  is selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 7  is selected from: C 1 -C 10  alkyl, alkylaryl, and common prodrug derivatives 
     E is (CR 8 R 9 ) m —W—(CR 8 R 9 ) n , 
     wherein W can be absent or selected from: 
     CH 2 , CO, O, S(O) m  and NR 10 , 
     m is 0-2, 
     n is 0-2; 
     with the proviso that when W is O, S or NR 10  then 
     m must not be 0; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, 
     C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O) m . 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH, or N. 
     with no more than two N in the cycle. 
     [6] More preferred compounds of the present invention are compounds of the formula (III):                           
     or a pharmaceutically acceptable salt form or a steroisomer thereof, wherein: 
     R 1  is selected from: 
     —C(O)NHOH 
     and common prodrug derivatives; 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H; a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 5  is selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a , 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-1  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 8  and R 9  is independently selected from: 
     H, 
     C 1 -C 8  alkyl substituted with 0-5 R b , 
     C 1 -C 8  alkenyl, 
     C 1 -C 8  alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 
     1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, C 1 -C 8  alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O) m . 
     R 10  is selected from: 
     hydrogen, 
     C 1 -C 8  alkyl 
     C 1 -C 8  alkylaryl 
     J 1 , J 2 , J 3 , J 4  are independently selected from: 
     CH, or N. 
     with no more than two N in the cycle. 
     [7] The more preferred compounds provided by this invention are compounds of the formula (IV):                           
     or a pharmaceutically acceptable salt form or a steroisomer therof, wherein: 
     R 2  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, 01-10 alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 3  is selected from the formula: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 5  is selected from: 
     
       
         U—X—Y—Z—U a —X a —Y a —Z a   
       
     
     wherein: 
     U is absent or is selected from: O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O ) NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R b  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     U a  is absent or is selected from: H, O, NR a , C(O), C(O)O, OC(O), C(O)NR a , NR a C(O), OC(O)O, OC(O)NR a , NR a C(O)O, NR a C(O)NR a , S(O) p , S(O) p NR a , NR a S(O) p , and NR a SO 2 NR a ; 
     X a  is absent or selected from H, C 1-10  alkylene, C 2-10  alkenylene, C 2-10  alkynylene; 
     Y a  is absent or selected from H, O, NR a , S(O) p , and C(O); 
     Z a  is absent or selected from H, a C 3-13  carbocyclic residue substituted with 0-5 R c  and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R c ; 
     R a , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     R a′ , at each occurrence, is independently selected from H, C 1-4  alkyl, phenyl or benzyl; 
     alternatively, R a  and R a′  taken together with the nitrogen to which they are attached form a 5 or 6 membered ring containing from 0-1 additional heteroatoms selected from the group consisting of N, O, and S; 
     R b , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , and CF 2 CF 3 ; 
     R c , at each occurrence, is independently selected from C 1-6  alkyl, OR a , Cl, F, Br, I, ═O, CN, NO 2 , NR a R a′ , C(O)R a , C(O)OR a , C(O)NR a R a′ , NR a S(O) 2 R a′ , S(O) 2 NR a R a′ , S(O) p R a , CF 3 , CF 2 CF 3 , and a 5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S; 
     R 8  and R 9  is independently selected from: 
     H, 
     C1-C8 alkyl substituted with 0-5 R b , 
     C1-C8 alkenyl, 
     C1-C8 alkylaryl substituted with 0-5 R b , 
     C 3-13  carbocyclic residue substituted with 0-5 R b , 
     5-14 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-5 R b ; 
     amino, C1-C8 alkyl-NR 10    
     hydroxyl, 
     R 8  and R 9  can also form a ring interrupted by NR 10 , O, S(O)m. 
     R 10  is selected from: 
     hydrogen, 
     C1-C8 alkyl 
     C1-C8 alkylaryl 
     [8] Most preferred compounds of the present invention include compounds selected from the group consisting of: 
     N1-(2(R)-hydroxy-1(S)-indanyl)-N4-hydroxy-2(R)-isobutyl-butanediamide; 
     N1-(2(R)-hydroxy-1(S)-indanyl)-N4-hydroxy-2(R)-isobutyl-3(S)-(5-hydroxycarbonyl)-pentanamide; 
     N1-(2(R)-hydroxy-1(S)-indanyl)-N4-hydroxy-2(R)-isobutyl-3(S)-methyl-butanediamide; 
     N1-(2(R)-hydroxy-1(S)-indanyl)-N4-hydroxy-2(R)-isobutyl-3(S)-propyl-butanediamide; 
     N1-(2(R)-hydroxy-1(S)-indanyl)-N4-hydroxy-2(R)-hexyl-3(S)-propyl-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-hydroxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-methoxy-phenyl)methyl]butanediamide; 
     N1-[1(S)-indanyl]-N4-hydroxy-2(R)-[4-(hydroxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-phenyl-propyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(benzyloxy)-phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[3-(benzyloxy)-phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-(fluoro-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3,4-(methylenedioxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(methoxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-trifluoromethyl-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-tert-butylaminosulfonyl-phenyl)phenyl]methyl]-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-methoxy-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-4-methoxy-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[3-(3-thiophene)isoxazoline]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-chloro-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-benzofuran)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-methyl-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[3,4-(methylenedioxy-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-tetrazole-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[3-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[3-methyl-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-(amino-phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(benzyloxy-carbonyl)amino]phenyl)methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-hydroxymethlene)phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3,4,5-trimethoxy-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2,4-di-methoxy-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3,5-di-chloro-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2-trifluoromethyl-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-isopropyl-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(2,4-dichloro-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-chloro-4-fluoro-phenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(p-toluenesulfonyl-amino)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-phenylmethyl-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3,4-methylenedioxyphenyl)phenyl]methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-methoxyphenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-fluorophenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(fluoro-phenyl)methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-nitrophenyl)phenyl]methyl]butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[[4-(3-(methylsulfonyl-amino)-phenyl)phenyl]methyl]-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-trimethylsilyl-propyl)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(ethyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(iso-butyloxy-carbonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(propionamido)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-cyclopropane carboxamido-1-yl)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(methylsulfonyl-amino)-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-amino-butanediamide; 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-(methylsulfonylamino)-phenyl)methyl]-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclobutane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-hydroxymethyl-isobutanamide)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-hydroxyl-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-phenyl-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(bezene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-cyano-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-phenyl-cyclopentane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-cyclohexane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-indole carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-furan carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-quinoline carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3,4,5-trimethoxy benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-3-amino-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-6-amino-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-pyridine carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-(2,4-dichloro-phenyl)-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-(4-chloro-phenyl)-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-methylsulfonyl)-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylsulfonyl-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-cyano-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(6-quinoline carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(1-ethyl, 3-methyl-pyrazole 5-carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3-(4-morpholino-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(2-chloro-4-methylsulfonyl-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(4-(imidazol-1-yl)benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(2-thiophene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(1-tert-butyl, 3-methyl-pyrazole 5-carboxamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(4-aminomethyl benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[(3-hydroxy-phenyl)methyl]-3(S)-(2-hydroxyl-isobutanamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopentane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-(3-(hydroxy-phenyl)methyl-3(S)-(2cyclopentyl acetamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclohexane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-(4-N-Boc-piperazinyl-1-yl)benzene carboxamido-1-yl)butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-(piperazinyl-1-yl)benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-Fluoro-6-chloro-benzene carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-amino-cyclohexane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylthio-acetamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methoxy-acetamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-allyl-cyclopentane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-n-propyl-cyclopentane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-allyl-cyclopropane carboxamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(8-quinoline-sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-nitro-benzene sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1,4-di-methyl-2-chloro-pyrazole-3-sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl-3(S)-(1,5-dimethyl-isooxazole-3-sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-imidazole 3-sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(benzene sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1,4-dimethyl pyrazole 3-sulfonamido)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylsulfonyl benzene sulfonamido-1-yl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclohexylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(iso-propylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4(2-trifluoromethylphenyl)-phenylmethyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopentylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopropylmethyl)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(benzylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-furanmethylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-4-methylphenyl)methyl]-3(S)-(3-cyanophenylmethylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-pentylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(bis-cyclopropylmethyamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-thiophenemethylamino)-butanediamide 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-propylamino)-butanediamide 
     The present invention also provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of formula (I) as described herein. 
     The present invention also provides for treating an inflammatory disease in a mammal comprising administering to the mammal in need of such treatment a therapeutically effective amount of a compound of formula (I) as described herein. 
     The present invention also provides a method for treating a condition or disease mediated by MMPs and/or TNF and/or aggrecanase in a mammal comprising administering to the mammal in need of such treatment a therapeutically effective amount of a compound of formula (I) as described herein. 
     The present invention alsoprovides a method for treating a condition or disease wherein the disease or condition is referred to as rheumatoid arthritis, osteoarthritis, periodontitis, gingivitis, corneal ulceration, solid tumor growth and tumor invasion by secondary metastases, neovascular glaucoma, multiple sclerosis, or psoriasis in a mammal comprising administering to the mammal in need of such treatment a therapeutically effective amount of a compound of formula (I) as described herein. 
     The present invention also provides a method for treating a condition or disease wherein the disease or condition is referred to as fever, cardiovascular effects, hemorrhage, coagulation, cachexia, anorexia, alcoholism, acute phase response, acute infection, shock, graft versus host reaction, autoimmune disease or HIV infection in a mammal comprising administering to the mammal in need of such treatment a therapeutically effective amount of a compound of formula (I) as described herein. 
     In the following description a (−) symbolizes the point of attachment. 
     SYNTHESIS 
     The novel compounds of the present invention may be prepared in a number of ways well known to one skilled in the art of organic synthesis. The compounds of the present invention can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or variations thereon as appreciated by those skilled in the art. Preferred methods include, but are not limited to, those described below. All references cited herein are hereby incorporated in their entirety herein by reference. 
     The novel compounds of this invention may be prepared using the reactions and techniques in this section. The reactions are performed in solvents appropriate to the reagents and materials employed and suitable for the transformation being effected. Also, in the description of the synthetic methods described below, it is to be understood that all proposed reaction conditions, including choice of solvents, reaction temperature, duration of the experiment and workup procedures, are chosen to be the conditions standard for that reaction, which should be readily recognized by one skilled in the art. It is understood by one skilled in the art of organic synthesis that the functionality present on various portions of the molecule must be compatible with the reagents and reactions proposed. Such restrictions to the substituents which are compatible with the reaction conditions will be readily apparent to one skilled in the art and alternate methods must then be used. 
     A series of compounds of formula 5 are prepared by the methods outlined in scheme 1. Coupling of carboxylic acid 1 with cis-(1S,2R-(−)-1-amino-2-indanol provided amide 2. The hydroxyl group of 2 was protected as the acetonide 3, followed by alkylation with tert-butyl 2-bromo-acetate to afford the desired diastereomer 4. Removal of the tert-butyl group of 4 with TFA in methylene chloride, followed by coupling with O-benzyl hydroxy amine, and hydrogenation afforded the target molecule 5.                          
     Compounds of formula 5 can also be prepared by the methods outlined in scheme 2. The 2-substituted succinic acid 10 can be prepared using standard Evans chemistry. An acid 6 (X=OH) is converted to its oxazolidinone derivative 8 using the standard chemistry. Asymmetric alkylation, followed by hydrolysis using H 2 O 2 /LiOH afforded the desired acid 10. The mono-protected succinic acid was coupled to (1S, 2R)-(−) cis-1-amino-2-indanol using standard BOP, or other peptide coupling reagents such as DCC, EDAC, TBTU. The intermediate 11 can then be readily converted into the target compounds 5 using the similar procedures to that used for the synthesis of target 5 as described in scheme 1.                           
     Compounds of formula 12 are prepared by the methods outlined in scheme 3. Dianion reaction of the intermidate 10 with an organic halides or triflates produces the 2,3-disubstituted succinate 13. The acid 13 was coupled with cis-(1S, 2R)-(−)-1-amino-2-indanol. Following similar procedures to that used for the synthesis of target 5 as described in scheme 1, compounds of formula 12 can be readily prepared.                           
     Compounds of formula 19 are prepared as shown in scheme 4. The intermediate 15 prepared using the method described in scheme 3, was hydrogenated to produce 16. Compound 16 was then converted to the triflate 17. The Pd catalyzed Suzuki or stille cross coupling of triflate 17 with either a boronic acid or organostanane afford the coupling product 18. Using the standard chemistry as described in scheme 3, 18 can be easily converted to the compounds of formula 19.                           
     Compounds of formula 20 are prepared as shown in scheme 5. Compound 21 prepared as described in scheme 2 can be hydrogenated to give the free amine 22. The free amino group can then be protected as sulfonamides, carbamates, and amides 23. Following similar chemistry to that described in scheme 1, compound 23 can be readily converted to the target of formula 20.                           
     Compounds of formula 24 are prepared as shown in scheme 6. Starting from 22 prepared in scheme 5, the free amino group can be further functionalized to afford compound 28 by either palladium catalyzed aryl amination (Wolfe, J. P.; Rennels, R. A.; Buchwald, S. L.  Tetrahedron , 1996, 52, 7525-7546, Hartwig, J. F.  Synlett , 1996, 329), or displacement with a substituted aryl fluoride. As described in the previous scheme 5, 28 can be easily converted to the final compound 24.                          
     Compounds of formula 29 are prepared as shown in schemes 7-9. 
     The synthesis of substituted cis-1-amino-2-indanol (36) was followed by the route developed by Ghosh et al Ghosh, A. K.; Kincaid, J. F.; Haske, M. G.  Synthesis , 1997, 541-544) The substituted indene (30) is converted to the epoxide 31 with MCPBA, or to the optically pure epoxide of 31 with Jacobsen&#39;s highly enantioselective epoxidation catalysts (Jacobsen, E. N.; Zhang, W.; Muci, A. R.; Ecker, J. R.; Deng, L. J.  Am. Chem. Soc . 1991, 113, 7063-7064.). The epoxide 31 is converted to the alcohol 32 by treating it with NaN 3 . The racemic alcohol of 32 is resolved by Lipase P Sas described by Ghosh et al (Ghosh, A. K.; Kincaid, J. F.; Haske, M. G.  Synthesis , 1997, 541-544). The azide of 33 was hydrogenated in the presence of O(CO 2 Et) 2  to give 34. The compound 34 was then converted to final substituted cis-1-amino-2-indanol 36 first by mixing with SOCl 2 , followed by hydrolysis.                           
     Alternatively, the substituted cis-1-amino-2-indanol 36 is directly prepared from substituted indene (30) following a method recently developed by Sharpless, K. B. et al as shown in scheme 8 (Li, G.; Angert, H. H.; Sharpless, K. B.  Angew. Chem. Int. Ed. Engl . 1996, 35, 2813). The cbz group of 38 was removed by hydrogenation to give the free amine 36.                          
     Following a similar sequence, the compound 36 can then be readily converted to the final compound 29 as shown in scheme 9.                           
     Compounds of formula 39 can be synthesized as shown in scheme 10. Following the method developed by Sudo and Saigo (Sudo, A.; Saigo, K. Tetrahedron Asymetry, 1996, 7, 2939-2956), the racemic cis-2-amino-1-indanol can be readily synthesized from substituted indanone 40 as outlined in scheme 9. The indanone can be readily converted into oxime 41 with butyl nitrile under acidic conditions. Reduction of 41 with NaBH 4  in methanol could provide the hydroxy oxime, which was then treated with acetic anhydride and pyridine to give diacetate 42. Borane reduction of 42 then gives the racemic 43, which can then be directly used or resolved by co-crystalization with tartaric acid or others to provide the desired enantiomerically pure amine 43. Using similar chemistry to that used for the synthesis of target 5 as described in scheme 1, compound 44 can be readily converted to the target 39.                           
     Compounds of formula 45 are synthesized as shown in scheme 11. The carboxylic group of commercially available aspartic acid was protected as methyl ester 47. Compound 47 was then treated with LiHMDS in THF at −78° C. to form the enolate, which was reacted with benzyl bromide to afford 48. The benzyl group of 48 was removed by hydrogenation. The resulting acid was then coupled with cis-2-amino indanol to give 49. Hydrolysis of compound 49, followed by coupling with hydroxy amine to furnish the desired target 45.                           
     Compounds of formula 50 are synthesized as shown in scheme 12. Compound 51 was prepared using the similar procedure to that used for the synthesis of compound 49 (see scheme 11). The amino protecting group of 51 was removed by TFA in methylene chloride. The free amino group was converted to its corresponding amide, carbamate and sulfonamide 53 using the standard chemistry. Hydrolysis of compound 53, followed by coupling with hydroxy amine to furnish the desired target 50.                           
     Compounds of formula 56 are synthesized as shown in scheme 13. The amino TFA salt 54 can be prepared as described in scheme 11 and scheme 12. The reductive amination of 54 with either ketone or aldehyde under the reducing agent of NaBH(OAc)3 provided the desired alkyl amine 55. The, benzyl or methyl group of 55 was removed by either hydrogenation or hydrolysis. The resulting acid was then coupled with hydroxy amine to furnish the desired target 56.                           
    
    
     EXAMPLES 
     Abbreviations used in the Examples are defined as follows: “1×” for once, “2×” for twice, “3×” for thrice, “° C.” for degrees Celsius, “eq” for equivalent or equivalents, “g” for gram or grams, “mg” for milligram or milligrams, “mL” for milliliter or milliliters, “ 1 H” for proton, “h” for hour or hours, “M” for molar, “min” for minute or minutes, “MHz” for megahertz, “MS” for mass spectroscopy, “NMR” for nuclear magnetic resonance spectroscopy, “rt” for room temperature, “tlc” for thin layer chromatography, “v/v” for volume to volume ratio. “R” and “S” are stereochemical designations familiar to those skilled in the art. 
     Example 1 
     N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-isobutyl-butanediamide 
     (a) N1(2R-Hydroxy-1S-indanyl)-2R-isobutyl-3-(tert-butoxycarbonyl)propanamide: 
     To a stirred, cooled (0° C.) solution of 500 mg (2.17 mmol) 2R-isobutyl 3-(tert-butoxycarbonyl)propinoic acid and 323.9 mg (2.17 mmol) (1S, 2R)-(−) cis-1-amino-2-indanol in 4.0 mL of anhydrous DMF was added 731.4 mg of TBTU, followed by addition of 1.19 mL of diisopropylethyl amine. The reaction was allowed to warm to room temperature. After 1 h, the reaction mixture was diluted with 15 mL 10% citric acid and 50 mL ethyl acetate, the aqueous solution was further extracted with ethyl acetate (2×25 mL). The combined organic solution was washed with water, sat. NaHCO 3 , and brine, dried over MgSO 4 . The solution was filtered and concentrated under reduced pressure to afford 0.685 g (87% yield) as a white solid. ESI-MS (M+H) + : calcd 362, found 362. 
     (b) N-(2R-Hydroxy-1S-indanyl)-2R-isobutyl-3-(hydroxycarbonyl)propanamide: 
     To a solution of 0.635 g of N-(2R-hydroxy-1S-indanyl)-2R-isobutyl-3-(tert-butoxycarbonyl) propanamide in 4.5 mL methylene chloride and 0.5 mL water was dropwise added 5.0 mL of TFA. The reaction was stirred at room temperature for 50 min. The solution mixture was concentrated, and dried by co-evaporation with toluene (3×15 mL). The resulting material was directly used in the next step. ESI-MS (M+H) + : calcd 306, found 306. 
     (c) N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-isobutyl-butanediamide: 
     To a cooled (0° C.) solution of 501.0 mg of N-(2R-hydroxy-1S-indanyl)-2R-isobutyl-3-(hydroxycarbonyl) propanamide in 6.4 mL DMF was added 786.5 mg of O-benzyl hydroxyamine-HCl, and 684.6 mg of TBTU, followed by addition of 1.71 mL of ethyldiisopropyl amine. The reaction was stirred at 0° C. for 15 min. and warmed to room temperature. After 4 h, the reaction mixture was poured into ethyl acetate/5% citric acid, the aqueous solution was extracted with ethyl acetate (3×25 mL). The combined organic solution was washed with 5% citric acid, water, sat. NaHCO 3 , brine, and dried over MgSO 4 . The solution was filtered and concentrated to afford 647 mg of desired product as a white solid. 
     To 323.5 mg of the above in 20 mL methanol was added 500 mg of 5% Pd/BaSO 4 . The mixture was shaken under 50 psi H 2  for 16 hours. The reaction mixture was filtered and concentrated and purified by reverse HPLC to afford 110 mg of the desired hydroxamic acid as a white solid. ESI-MS (M+H) + : calcd 321, found 321. 
     Example 2 
     N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-isobutyl-3(S)-(3-propionic Acid)-butanediamide 
     Following a procedure analogous to that used in example 1, 2R-isobutyl 3S-(tert-butoxycarbonyl) 5-benzoxycarbonyl pentanoic acid was coupled with (1S, 2R)-(−) cis-1-amino-2-indanol using TBTU as the coupling reagent. Removal of tert-butyl protecting group was achieved by treating with TFA as described in example 1, followed by coupling with O-benzyl hydroxyamine-HCl mediated by TBTU. The resulting material was hydrogenated to afford the desired product. ESI-MS (M+H) + : calcd 393, found 393. 
     Example 3 
     N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-isobutyl-3(S)-methyl-butanediamide 
     Following a procedure analogous to that used in example 1, 2R-hexyl 3S-(tert-butoxycarbonyl) butanoic acid was coupled with (1S, 2R)-(−) cis-1-amino-2-indanol using TBTU as the coupling reagent. Removal of tert-butyl protecting group was achieved by treating with TFA as described in example 1, followed by coupling with O-benzyl hydroxyamine-HCl mediated by TBTU or BOP. The resulting material was hydrogenated to afford the desired product as a white solid. ESI-MS (M+H)+: calcd 335, found 335. 
     Example 4 
     N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-isobutyl-3(S)-propyl-butanediamide 
     Following a procedure analogous to that used in example 1, 2R-isobutyl 3S-(tert-butoxycarbonyl) hexanoic acid was coupled with (1S, 2R)-(−) cis-1-amino-2-indanol using TBTU as the coupling reagent. Removal of tert-butyl protecting group was achieved by treating with TFA as described in example 1, followed by coupling with O-benzyl hydroxyamine-HCl mediated by TBTU or BOP. The resulting material was hydrogenated to afford the desired product as a white solid. ESI-MS (M+H) + : calcd 363, found 363. 
     Example 5 
     N1(2(R)-Hydroxy-1(S)-indanyl)-N-4-hydroxy-2(R)-hexyl-3(S)-propyl-butanediamide 
     Following a procedure analogous to that used in example 1, 2R-hexyl 3S-(tert-butoxycarbonyl) hexanoic acid was coupled with (1S, 2R)-(−) cis-1-amino-2-indanol using TBTU as the coupling reagent. Removal of tert-butyl protecting group was achieved by treating with TFA as described in example 1, followed by coupling with O-benzyl hydroxyamine-HCl mediated by TBTU or BOP. The resulting material was hydrogenated to afford the desired product as a white solid. ESI-MS (M+H)+: calcd 391, found 391. 
     Example 6 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[4-hydroxy-phenyl)methyl]-butanediamide 
     (a) Preparation of N-(2R-Hydroxy-1S-indanyl)-3-(4-benzyloxy-phenyl)-propanamide: 
     To a stirred, cooled (0° C.) solution of 10 g (39.1 mmol) 3-(4-benzyloxy-phenyl)-propinoic acid and 7 g (46.92 mmol) (1S, 2R)-(−) cis-1-amino-2-indanol in 200 mL of anhydrous DMF was added 17.3 g BOP as a solid, followed by addition of 20 mL of diethylisopropyl amine. The reaction was allowed to warm to room temperature. After 5 h, the reaction mixture was diluted with 100 mL 10% citric acid and 100 mL ethyl acetate, the aqueous solution was further extracted with ethyl acetate (2×50 mL). The combined organic solution was washed with water, sat. NaHCO 3 , and brine, dried over MgSO 4 . The solution was filtered and concentrated under reduced pressure to afford 15.1 g desired product as a white solid. ESI-MS (M+H) + : calcd 388, found 388. 
     (b) N-(1S,2R-N,O-Dimethyl Acetonide-indanyl)-3-(4-benzyloxy-phenyl)-propanamide: 
     To a stirred, cooled (0° C.) solution of 15.1 g N-(2R-hydroxy-1S-indanyl)-3-(4-benzyloxy-phenyl)-propanamide and 1.14 g of PPTS in 300 mL of methylene chloride was slowly added 30 ml of 2-methoxy propene. The solution was slowly warmed to room temperature and stirred overnight. The reaction was quenched by addition of 50 mL of sat. NaHCO 3 , and extracted with ethyl acetate (3×50 mL). The combined solution was washed with sat NaHCO 3 , water, brine, and dried over MgSO 4 . The solution was filtered and concentrated. The crude material was purified by flash column (Ethyl acetate/Hexane: 40:60) to give 15.3 g desired product as a white solid. ESI-MS (M+H) + : calcd 428, found 428. 
     (c) N-(1S, 2R-N,O-Dimethyl Acetonide-indanyl)-2R-(4-benzyloxy-phenylmethyl)-3-(tert-butoxycarbonyl-propanamide: 
     To a stirred and cooled (−78° C.) solution of 3.0 g (7.0 mmol) of N-(2R-hydroxy-1S-indanyl)-3-(4-benzyloxy-phenyl)-propanamide in 20 mL THF was dropwise added a freshly prepared, cooled (−78° C.) LDA (7.0 mmol) in THF. After 1.0 hour, a solution of 1.14 mL (7.7 mmol) tert-butyl 2-bromoacetate in 3.0 ml THF was added dropwise. The resulting solution was incubated at −78° C. for 4.0 h. The reaction was quenched by addition of 10% citric acid, and extracted with ethyl acetate (3×100 mL). The combined organic solution was washed with water, brine, and dried over MgSO 4 . The solution was filtered and concentrated. The crude material was purified by flash column with (Ethyl acetate/Hexane: 15-25:85-75) to afford the desired product (2.8 g, 71% yield) as a white solid, and 0.1 g of other diastereomer. ESI-MS (M+H) + : calcd 542, found 542. 
     (d) N-(2R-Hydroxy-1S-indanyl)-2R-(4-benzyloxy-phenylmethyl)-3-(hydroxy-carbonyl)propanamide: 
     To a solution of 1.13 g of N-(2R-hydroxy-1S-indanyl)-2R-(4-Benzyloxy-phenylmethyl)-3-(tert-butoxycarbonyl) propanamide in 7.6 mL methylene chloride and 0.4 mL water was dropwise added 8.0 mL of TFA. The reaction was stirred at room temperature for 50 min. The solution mixture was concentrated to half of its original volume. The residue was then dried by co-evaporation with toluene (3×15 mL) and directly used in the next step. ESI-MS (M+H) + : calcd 446, found 446. 
     (e) N-(2R-Hydroxy-1S-indanyl)-2K-(4-benzyloxy-phenylmethyl)-3-(N-hydroxyaminocarbonyl)propan-amide: 
     To a cooled (0° C.) solution of 104 mg of N-(2R-hydroxy-1S-indanyl)-2R-(4-Benzyloxy-phenylmethyl)-3-(hydroxy-carbonyl) propanamide in 1.2 mL DMF was added 112 mg of O-benzyl hydroxylamine-HCl, and 78.8 mg of TBTU, followed by addition of 0.24 mL of ethyldiisopropyl amine. The reaction was stirred at 0° C. for 15 min. and warmed to room temperature. After 2 h, the reaction mixture was poured into ethyl acetate/5% citric acid, the aqueous solution was extracted with ethyl acetate (3×25 mL). The combined organic solution was washed with 5% citric acid, water, sat. NaHCO 3 , brine, and dried over MgSO 4 . The solution was filtered and concentrated to afford 105 mg of desired product. 
     To 105 mg of the above in 6 mL methanol was added 60 mg of 5% Pd/BaSO 4 . The mixture was shaken under 50 psi H 2  for 4 hour. The reaction mixture was filtered and concentrated and purified by reverse HPLC to afford 47 mg of the desired hydroxamic acid as a white solid. ESI-MS (M+H) + : calcd 371, found 371. 
     Example 7 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[4-methoxy-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 385, found 385. 
     Example 8 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4-(hydroxy-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 355, found 355. 
     Example 9 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-phenyl-propyl]butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 383, found 383. 
     Example 10 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(benzyloxy)-phenyl]methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 461, found 461. 
     Example 11 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[3-(benzyloxy)-phenyl]methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 461, found 461. 
     Example 12 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[(3-(hydroxy-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 371, found 371. 
     Example 13 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[4-(fluoro-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) +: calcd 373, found 373. 
     Example 14 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3,4-(methylenedioxy-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 379, found 379. 
     Example 15 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(methoxy-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 385, found 385. 
     Example 16 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(phenyl)phenyl]methyl]-butanediamide 
     (a) N-(1S,2R-N,O-Dimethyl Acetonide-indanyl)-2R-(4-phenyl)phenylmethyl-3-(tert-butoxycarbonyl)propanamide 
     To 2.6 g N-(1S,2R-N,O-dimethyl acetonide-indanyl)-2R-(4-Benzyloxy-phenylmethyl)-3-(tert-butoxycarbonyl) propanamide in 20 mL methanol was added 300 mg of 5% Pd/C. The mixture was shaken under 50 psi H 2  for 17 hours. The reaction mixture was filtered and concentrated to afford 2.0 g of the desired product. 
     To a cooled (0° C.) solution of 1.2 g of N-(2R-hydroxy-1S-indanyl)-2R-(4-hydroxy-phenylmethyl)-3-(tert-butoxycarbonyl) propanamide and 0.95 g of PhN(tf) 2  in 9.0 mL of methylene chloride was dropwise added 0.77 mL Et 3 N. After 45 min at 0° C., the reaction mixture was diluted in ethyl ether (60 mL), washed with sat NaHCO 3 , brine, and dried over MgSO 4 . The crude mater was purified by flash column with 20% ethyl acetate in hexane to afford the desired product as a colorless oil. 
     To a solution of 192.0 mg of above material and 22 mg of PPh 3  in 1.4 mL toluene and 1.4 mL 0.35M Na 2 CO 3  aq. solution was added catalytical amount (6.0 mg) of Pd(Ac) 2 . The resulting mixture was stirred at 60° C. for 10 min, followed by addition of 44 mg of benzene bornic acid as solid. The reaction was heated at 70° C. After four hours, the reaction mixture was then diluted with ethyl acetate, washed with water, brine, and dried over MgSO4. The crude material was purified by 15% ethyl acetate in hexane to afford 127.1 mg of desired product as a colorless oil. ESI-MS (M+H) + : calcd 431, found 431. 
     (b) N-(2R-Hydroxy-1S-indanyl)-2R-(4-phenyl)phenyl-methyl-3-(N-hydroxyaminocarbonyl)propanamide: 
     Following the method used in the synthesis of example 1, the above N-(1S ,2R-N,O-dimethyl acetonide-indanyl)-2R-(4-phenyl)phenylmethyl-3-(tert-butoxycarbonyl) propanamide was treated with TFA, followed by coupling with hydroxylamine to yield the desired N-(2R-hydroxy-1S-indanyl)-2R-(4-phenyl)-phenylmethyl-3-(N-hydroxyaminocarbonyl)-propanamide as a white solid. ESI-MS (M+H) + : calcd 431.2, found 431.2. 
     Example 17 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-tert-butylaminosulfonyl-phenyl)phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 566, found 566. 
     Example 18 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-methoxy-phenyl)phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 461, found 461. 
     Example 19 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-trifluoromethyl-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 499, found 499. 
     Example 20 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[(3-hydroxy-4-methylphenyl)-methyl]butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 401, found 401. 
     Example 21 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[3-(3-thiophene-isoxazoline]-methyl]butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 429, found 429. 
     Example 22 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-chloro-phenyl)-phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 465.5, found 465.5. 
     Example 23 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-benzofuran)-phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 471, found 471. 
     Example 24 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-methyl-phenyl)-phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 445, found 445. 
     Example 25 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[(3,4-(methylenedioxy-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 475, found 475. 
     Example 26 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-tetrazole-phenyl)-phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 499, found 499. 
     Example 27 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[3-phenyl)phenyl]methyl]-butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 431, found 431. 
     Example 28 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[3-methyl-phenyl)phenyl]methyl]-butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 445, found 445. 
     Example 29 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[4-(amino-phenyl)methyl]-butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 370, found 370. 
     Example 30 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[(4-(benzyloxy-carbonyl)-amino]phenyl)methyl]butanediamide 
     Prepared by the method described in example 6 to give the desired material. ESI-MS (M+H) + : calcd 504, found 504. 
     Example 31 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-hydroxymethlene)phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 461, found 461. 
     Example 32 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3,4,5-trimethoxy-phenyl)phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 521, found 521. 
     Example 33 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2,4-di-methoxy-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 491, found 491. 
     Example 34 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3,5-di-chloro-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 499, found 499. 
     Example 35 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2-trifluoromethyl-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 499, found 499. 
     Example 36 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-isopropyl-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 473, found 473. 
     Example 37 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(2,4-dichloro-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 499, found 499. 
     Example 38 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-chloro-4-fluoro-phenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 483, found 483. 
     Example 39 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(p-toluenesulfonylamino)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 524, found 524. 
     Example 40 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-phenylmethyl-3(S)-(tert-butyloxy-carbonyl-amino)butanediamide 
     To a solution of 20 g of Boc-Asp(OBn)-OH and 8.9 g of K 2 CO 3  in 200 mL DMF was added 4.04 mL of CH 3 I. The reaction mixture was stirred at room temperature for 12 h. The mixture was diluted in water, extracted with diethyl ether. The combined organic layer was washed with sat. NaHCO 3 , water and brine. The crude material was recrystalized from diethyl ether and hexane to afford 19.2 g of the desired product Boc-Asp(OBn)-OCH 3 . 
     To a cooled (−78° C.) solution of 2.5 g of compound Boc-Asp(OBn)-OCH 3  in 49 mL toluene was added dropwise 15.2 mL of (1.0 M in THF) LiHMDS over 15 min. The resulting solution was stirred at −78° C. for 1.0 h, followed by addition of 1.4 mL benzyl bromide. The solution was stirred at −50° C overnight. The reaction was quenched with 10% citric acid, and extracted with diethyl ether. The organic layer was washed with sat. brine, dried over Na 2 SO 4 . The crude material was purified by 15% ethyl acetate to afford 2.1 g (64% yield) of desired product. 
     1.0 g (2.34 mmmol) above product and 500 mg of 10% Pd/C was hydrogenated at 32 Psi for two hour. The reaction mixture was filtered, and concentracted to afford a residue. 
     678 mg (2.01 mmol) above acid was coupled with 314 mg cis-2-amino indanol using 933 mg of BOP as the coupling reagent in DMF to afford 867 mg of coupling product N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-phenylmethyl-3(S)-(tert-butyloxy-carbonyl-amino)-4-(tert-butoxycarbonyl)-butan-amide. 
     To a cooled solution of 268 mg of N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-phenylmethyl-3(S)-(tert-butyloxy-carbonyl-amino)-4-(tert-butoxycarbonyl)butan-amide. in 4.3 mL THF was added 0.43 mL (2.5 M in H 2 O) LiOH solution. The reaction mixture was stirred at 0° C. for 30 min. The reaction was quenched with 10% citric acid, extracted with EtOAc, the organic layer was washed with sat. brine, and dried over Na 2 SO 4 . The solvent was removed to afford 252.1 mg of the product as white solid. 
     The above acid (252 mg, 0.555 mmol) was treated with 257 mg of BOP and 116 mg of hydroxylamine in DMF. The crude material was purified by RP-HPLC (column: 41.5×250 mm C18 dynamax, gradient: 15 to 65% acetonitrile with 0.1% TFA over 25 min. The sample was detected at 220 nM.) to give the desired material N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-phenylmethyl-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide, ESI-MS (M+H) + : calcd 470, found 470. 
     Example 41 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3,4-methylenedioxyphenyl)-phenyl]methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 588, found 588. 
     Example 42 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-methoxyphenyl)-phenyl]methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 461, found 461. 
     Example 43 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-fluororphenyl)-phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 449, found 449. 
     Example 44 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(fluoro-phenyl)methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 488, found 488. 
     Example 45 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 486, found 486. 
     Example 46 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-nitrophenyl)phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 476, found 476. 
     Example 47 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[[4-(3-(methylsulfonyl-amino)-phenyl)phenyl]-methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 524, found 524. 
     Example 48 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-butanediamide 
     Step 1: To a solution of 1.55 g of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(tert-butyloxy-carbonyl-amino)-Succinamic methyl ester was added 20 mL of 4N Hcl in dioxane at RT. The resulting solution was stirred at room temperature for 25 min. The reaction mixture was concentracted to afford 1.45 g of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-amino-Succinamic methyl ester as a white solid. 
     Step 2: To a ice cold solution of 166 mg (0.43 mmol) of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-amino-Succinamic methyl ester and 88 mg (0.86 mmol) of 2,2-dimethyl-propionic acid in 2.15 mL DMF was added 145 mg TBTU (0.45 mmol) as a solid, followed by addition of 0.23 mL of hunig base. The resulting solution was stirred at room temperature for two hours. The mixture was diluted in 5% NaHCO3 solution, and extracted with ethyl acetate (3×20 mL). The combined organic layer was washed with saturated brine, and dried with MgSO4. Flash column of the crude material with 50% ethyl acetate in hexane to give 189 mg (94% yield) of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-Succinamic methyl ester as a off white solid. 
     Step 3: To a ice cold solution of 176 mg of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-Succinamic methyl ester in 2.0 mL of THF was added 0.38 mL LiOH solution (2.5M). The resulting solutionon was stirred at 0° C. for 30 min. The reaction was quenched with 0.35 mL HCl (3N) solution, and extracted with ethyl acetate (3×10 mL). The combined solution was washed with saturated brine, dried over Na2SO4. The solution was then filterted and concentracted to afford 152 mg of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-Succinamic acid as an off white solid. 
     Step 4: To an ice cold solution of 135 mg (0.297 mmol) of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-Succinamic acid in 1.5 mL DMF was added 131 mg of BOP, followed by addition of 62 mg hydroxy amine and 0.15 mL hunig base. The resulting solution was stirred at room temperature for three hour. The crude material was directly purified on reverse-HPLC to afford 82 mg of the desired N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propionamido)-butanediamide as white solid. ESI-MS (M+H) + : calcd 470, found 470. 
     Example 49 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(ethyloxy-carbonyl-amino)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 458, found 458. 
     Example 50 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(iso-butyloxy-carbonyl-amino)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 486, found 486. 
     Example 51 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(propionamido)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 458, found 458. 
     Example 52 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-cyclo-propane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 452, found 452. 
     Example 53 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethyl-propyl-amino)-butanediamide 
     Step 1: A solution of 2.1 g of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-amino-Succinamic methyl ester in 18 mL 1,2-dichloroethane was mixed with 0.55 mL of pivaldehyde and 1.10 mL of hunig base for 20 min, followed by addition of 1.79 g of NaBH(OAc)3 as a solid. The resulting solution was stirred at room temperature for 3 hour. The reaction mixtur was diluted in 5% NaHCO3 and extracted with ethyl acetate (3×30 mL). The combined solution was washed with saturated brine. The crude material was purified on silica with 30-50% ethyl acetate in hexane to give 1.44 g of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-Succinamic methyl ester. 
     Step 2: To a ice cold solution of 290 mg of N1-[2(R)-hydroxy-1(S)-indanyl]-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-Succinamic methyl ester in 2.5 mL THF was added 0.63 mL of LiOH (2.5 M). The reaction mixture was stirred at 0° C. for 30 min. The reaction was quenched with 0.6 ml HCl solution (3N), tha mixture was then freeze dried. 
     Step 3: To an ice cold solution of above material in 1.5 mL DMF was added 295 mg of BOP, followed by addition of 264 mg hydroxyl amine and 0.8 mL hunig base. The resulting solution was stirred at room temperature for three hour. The crude material was directly purified on reverse-HPLC to afford 85 mg of the desired N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide as a white solid. ESI-MS (M+H) + : calcd 455, found 455. 
     Example 54 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(methylsulfonyl-amino)-butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 464, found 464. 
     Example 55 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-13-(hydroxy-phenyl)methyl]-3(S)-amino-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 386, found 386. 
     Example 56 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[4-(methylsulfonylamino)-phenyl)methyl]butanediamide 
     Prepared by the method described in example 16 to give the desired material. ESI-MS (M+H) + : calcd 448, found 448. 
     Example 57 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclobutane carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 468.5, found 468.5. 
     Example 58 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-hydroxymethyl-isobutanamide)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 486.5, found 486.5. 
     Example 59 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-1-hydroxyl-cyclopropane carboxyamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 470.5, found 470.5. 
     Example 60 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-phenyl-cycylopropane carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 530.6, found 530.6. 
     Example 61 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(bezene carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 490.5, found 490.5. 
     Example 62 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-cyano-cyclopropane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 479.5, found 479.5. 
     Example 63 
     N1-[2(R)-hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-phenyl-cyclopentane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 558.6, found 558.6. 
     Example 64 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-cyclohexane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 510.6, found 510.6. 
     Example 65 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-hydroxy-phenyl)methyl]-3(S)-2-indole Carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 529.6, found 529.6. 
     Example 66 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-furan Carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 480.5, found 480.5. 
     Example 67 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-quinoline Carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 541.6, found 541.6. 
     Example 68 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3,4,5-trimethoxy Benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 580.6, found 580.6. 
     Example 69 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-3-amino-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 519.6, found 519.6. 
     Example 70 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-6-amino-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 519.6, found 619.6. 
     Example 71 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-pyridine Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 491.5, found 491.5. 
     Example 72 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-(2,4-dichloro-phenyl)-cyclopropane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 599.6, found 599.6. 
     Example 73 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-(4-chloro-phenyl)-cyclopropane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 565, found 565. 
     Example 74 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-methylsulfonyl)-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 568.6, found 568.6. 
     Example 75 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylsulfonyl-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 568.6, found 568.6. 
     Example 76 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(3-cyano-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 515.5, found 515.5. 
     Example 77 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(6-quinoline Carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 541.6, found 541.6. 
     Example 78 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-ethyl, 3-Methyl-pyrazole 5-Carboxamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 522.6, found 522.6. 
     Example 79 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3-(4-morpholino-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 575.6, found 575.6. 
     Example 80 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-chloro-4-methylsulfonyl-benzene Carboxyamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 603, found 603. 
     Example 81 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-(imidazol-1-yl)benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 556.6, found 556.6. 
     Example 82: 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-thiophene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 496.6, found 496.6. 
     Example 83 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N-4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-tert-butyl, 3-Methyl-pyrazole 5-Carboxamido)-butanediamide 
     Prepared by the method described in example 40 to give the desired material. ESI-MS (M+H) + : calcd 550.6, found 550.6. 
     Example 84 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-aminomethyl benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 519.6, found 519.6. 
     Example 85 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-hydroxyl-isobutanamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 472.6, found 472.6. 
     Example 86 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopropane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 454.6, found 454.6. 
     Example 87 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopentane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 482.6, found 482.6. 
     Example 88 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-cyclopentyl Acetamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 496.6, found 496.6. 
     Example 89 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclohexane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 496.6, found 496.6. 
     Example 90 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-(4-N-Boc-piperazinyl-1-yl)benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 674.8, found 674.8. 
     Example 91 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-[4-(piperazinyl-1-yl)benzene Carboxamido-1-yl]-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 574.6, found 574.6. 
     Example 92 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-fluoro-6-chloro-benzene Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 542.9, found 542.9. 
     Example 93 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-amino-cyclohexane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 511.6, found 511.6. 
     Example 94 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylthio-acetamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 474.6, found 474.6. 
     Example 95 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methoxy-acetamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 458.5, found 458.5. 
     Example 96 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-allyl-cyclopentane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 522.6, found 522.6. 
     Example 97 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-n-propyl-cyclopentane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 524.6, found 524.6. 
     Example 98 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-allyl-cyclopropane Carboxamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 494.6, found 494.6. 
     Example 99 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(8-quinoline-sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 577.6, found 577.6. 
     Example 100 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(4-nitro-benzene Sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 571.6, found 571.6. 
     Example 101 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1,4-di-methyl-2-chloro-pyrazole-3-sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 579, found 579. 
     Example 102 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1,5-dimethyl-isooxazole 3-sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 545.6, found 545.6. 
     Example 103 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1-methyl-imidazole 3-sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 530.6, found 530.6. 
     Example 104 
     N1-[2(R)-(Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(benzene Sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 526.6, found 526.6. 
     Example 105 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(1,4-dimethyl Pyrazole 3-Sulfonamido)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 544.6, found 544.6. 
     Example 106 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methylsulfonyl Benzene Sulfonamido-1-yl)-butanediamide 
     Prepared by the method described in example 48 to give the desired material. ESI-MS (M+H) + : calcd 604.7, found 604.7. 
     Example 107 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclohexylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 468, found 468. 
     Example 108 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(iso-propylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 428, found 428. 
     Example 109 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[4(2-trifluoromethylphenyl)-phenylmethyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 584, found 584. 
     Example 110 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopentylamino)-butanediamide 
     Prepared by the method described in example 53 to 10 give the desired material. ESI-MS (M+H) + : calcd 454.5, found 454.5. 
     Example 111 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(cyclopropylmethylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 440.5, found 440.5. 
     Example 112 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(benzylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 476.5, found 476.5. 
     Example 113 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-furanmethylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 466.5, found 466.5. 
     Example 114 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-4-methylphenyl)methyl]-3(S)-(3-cyanophenylmethylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 501.5, found 501.5. 
     Example 115 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-4-methylphenyl)methyl]-3(S)-(2,2-dimethylpropyl-amino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 470.6, found 470.6. 
     Example 116 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-pentylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 456.6, found 456.6. 
     Example 117 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(bis-cyclopropylmethyamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 494.6, found 494.6. 
     Example 118 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-thiophenemethylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 482.6, found 482.6. 
     Example 119 
     N1-[2(R)-Hydroxy-1(S)-indanyl]-N4-hydroxy-2(R)-[3-(hydroxy-phenyl)methyl]-3(S)-(2-methyl-propylamino)-butanediamide 
     Prepared by the method described in example 53 to give the desired material. ESI-MS (M+H) + : calcd 556.6, found 556.6. 
     
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                   
                   
                   
                 M + 
               
               
                 Ex # 
                 R 2   
                 R 3   
                 H 
               
               
                   
               
             
          
           
               
                 1 
                 H 
                 iso-butyl 
                 321 
               
               
                 2 
                 CH 2 CH 2 CO 2 H 
                 iso-butyl 
                 393 
               
               
                 3 
                 methyl 
                 iso-butyl 
                 335 
               
               
                 4 
                 n-propyl 
                 iso-butyl 
                 363 
               
               
                 5 
                 n-propyl 
                 n-C 6 H 13   
                 391 
               
               
                 6 
                 H 
                 4-hydroxyphenylmethyl 
                 371 
               
               
                 7 
                 H 
                 4-methoxyphenylmethyl 
                 385 
               
               
                 8 
                 H 
                 4-hydroxyphenylmethyl 
                 355 
               
               
                 9 
                 H 
                 3-phenylpropyl 
                 383 
               
               
                 10 
                 H 
                 4-benzyloxyphenylmethyl 
                 461 
               
               
                 11 
                 H 
                 3-benzyloxyphenylmethyl 
                 461 
               
               
                 12 
                 H 
                 3-hydroxyphenylmethyl 
                 371 
               
               
                 13 
                 H 
                 4-fluorophenylmethyl 
                 373 
               
               
                 14 
                 H 
                 3,4-methylenedioxy 
                 379 
               
               
                   
                   
                 phenylmethyl 
               
               
                 15 
                 H 
                 3-methoxyphenylmethyl 
                 385 
               
               
                 16 
                 H 
                 4-phenyl-phenylmethyl 
                 431 
               
               
                 17 
                 H 
                 4-(2-(tert- 
                 566 
               
               
                   
                   
                 butylaminosulfonyl)- 
               
               
                   
                   
                 phenylphenylmethyl 
               
               
                 18 
                 H 
                 4-(2-methoxyphenyl)- 
                 461 
               
               
                   
                   
                 phenylmethyl 
               
               
                 19 
                 H 
                 4-(3-trifluoromethyl- 
                 499 
               
               
                   
                   
                 phenyl)-phenylmethyl 
               
               
                 20 
                 H 
                 (3-hydroxy-4- 
                 401 
               
               
                   
                   
                 methoxy)phenylmethyl 
               
               
                 21 
                 H 
                 3-(3-thiophene)- 
                 429 
               
               
                   
                   
                 isoxazoline-methyl 
               
               
                 22 
                 H 
                 4-(2-chlorophenyl)- 
                 465 
               
               
                   
                   
                 phenylmethyl 
               
               
                 23 
                 H 
                 4-(2-benzofuran)- 
                 471 
               
               
                   
                   
                 phenylmethyl 
               
               
                 24 
                 H 
                 4-(2-methylphenyl)-phenyl- 
                 445 
               
               
                   
                   
                 methyl 
               
               
                 25 
                 H 
                 (3,4-methylene- 
                 475 
               
               
                   
                   
                 dioxyphenyl)phenyl-methyl 
               
               
                 26 
                 H 
                 4-(2-tetrazolephenyl)- 
                 499 
               
               
                   
                   
                 phenyl-methyl 
               
               
                 27 
                 H 
                 3-phenylphenylmethyl 
                 431 
               
               
                 28 
                 H 
                 (3-methyl-phenyl)- 
                 445 
               
               
                   
                   
                 phenylmethyl 
               
               
                 29 
                 H 
                 4-amino-phenylmethyl 
                 370 
               
               
                 30 
                   
                 4-benzyloxy- 
                 504 
               
               
                   
                   
                 carbonyl-amino-phenylmethyl 
               
               
                 31 
                 H 
                 4-(2-hydroxymethylene- 
                 461 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 32 
                 H 
                 4-(3,4,5-trimethoxy- 
                 521 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 33 
                 H 
                 4-(2,4-dimethoxy- 
                 491 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 34 
                 H 
                 4-(3,5-dichloro-phenyl)- 
                 499 
               
               
                   
                   
                 phenylmethyl 
               
               
                 35 
                 H 
                 4-(2-trifluoromethyl- 
                 499 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 36 
                 H 
                 4-(3-isopropyl- 
                 473 
               
               
                   
                   
                 phenyl)phenyl-methyl 
               
               
                 37 
                 H 
                 4-(2,4-dichloro- 
                 499 
               
               
                   
                   
                 phenyl)phenyl-methyl 
               
               
                 38 
                 H 
                 4-(3-chloro,4-fluoro- 
                 483 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 39 
                 H 
                 4-(p-toluenesulfonyl- 
                 524 
               
               
                   
                   
                 amino)-phenylmethyl 
               
               
                 40 
                 BocNH 
                 phenylmethyl 
                 470 
               
               
                 41 
                 BocNH 
                 4-(3,4-methylenedioxy- 
                 588 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 42 
                 H 
                 4-(3-methoxy- 
                 461 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 43 
                 H 
                 4-(3-fluoro- 
                 449 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 44 
                 BocNH 
                 3-fluorophenylmethyl 
                 488 
               
               
                 45 
                 BocNH 
                 3-hydroxyphenylmethyl 
                 486 
               
               
                 46 
                 H 
                 4-(3-nitro- 
                 476 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 47 
                 H 
                 4-(3-methylsulfonylamino- 
                 524 
               
               
                   
                   
                 phenyl)phenylmethyl 
               
               
                 48 
                 2,2-dimethylpropionamido 
                 3-hydroxyphenylmethyl 
                 470 
               
               
                 49 
                 ethoxycarbonylamino 
                 3-hydroxyphenylmethyl 
                 458 
               
               
                 50 
                 iso-butoxy-carbonyl-amino 
                 3-hydroxyphenylmethyl 
                 486 
               
               
                 51 
                 propionamido 
                 3-hydroxyphenylmethyl 
                 458 
               
               
                 52 
                 1-methylcyclopropane 
                 3-hydroxyphenylmethyl 
                 452 
               
               
                   
                 carboxamido-1-yl 
               
               
                 53 
                 2,2-dimethylpropylamino 
                 3-hydroxyphenylmethyl 
                 455 
               
               
                 54 
                 methylsulfonylamino 
                 3-hydroxyphenylmethyl 
                 464 
               
               
                 55 
                 amino 
                 3-hydroxyphenylmethyl 
                 386 
               
               
                 56 
                 H 
                 4-(methylsulfonyl- 
                 448 
               
               
                   
                   
                 amino)phenylmethyl 
               
               
                 57 
                 cyclobutane carboxamido- 
                 3-hydroxyphenylmethyl 
                 468.5 
               
               
                   
                 1-yl 
               
               
                 58 
                 2-hydroxymethyl- 
                 3-hydroxyphenylmethyl 
                 486.5 
               
               
                   
                 isobutanamide 
               
               
                 59 
                 1-hydroxyl-cyclopropane 
                 3-hydroxyphenylmethyl 
                 470.5 
               
               
                   
                 carboxyamido-1-yl 
               
               
                 60 
                 1-phenyl-cyclopropane 
                 3-hydroxyphenylmethyl 
                 530.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 61 
                 bezene carboxamido 
                 3-hydroxyphenylmethyl 
                 490.5 
               
               
                 62 
                 1-cyano-cyclopropane 
                 3-hydroxyphenylmethyl 
                 479.5 
               
               
                   
                 carboxamido-1-yl 
               
               
                 63 
                 1-phenyl-cyclopentane 
                 3-hydroxyphenylmethyl 
                 558.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 64 
                 1-methyl-cyclohexane 
                 3-hydroxyphenylmethyl 
                 510.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 65 
                 2-indole carboxamido 
                 3-hydroxyphenylmethyl 
                 529.6 
               
               
                 66 
                 2-furan carboxamido 
                 3-hydroxyphenylmethyl 
                 480.5 
               
               
                 67 
                 2-quinoline carboxamido 
                 3-hydroxyphenylmethyl 
                 541.6 
               
               
                 68 
                 3,4,5-trimethoxy benzene 
                 3-hydroxyphenylmethyl 
                 580.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 69 
                 2-methyl-3-amino-benzene 
                 3-hydroxyphenylmethyl 
                 519.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 70 
                 2-methyl-6-amino-benzene 
                 3-hydroxyphenylmethyl 
                 619.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 71 
                 3-pyridine carboxamido-1- 
                 3-hydroxyphenylmethyl 
                 491.5 
               
               
                   
                 yl 
               
               
                 72 
                 1-(2,4-dichloro-phenyl)- 
                 3-hydroxyphenylmethyl 
                 599.6 
               
               
                   
                 cyclopropane carboxamido- 
               
               
                   
                 1-yl 
               
               
                 73 
                 1-(4-chloro-phenyl)- 
                 3-hydroxyphenylmethyl 
                 565 
               
               
                   
                 cyclopropane carboxamido- 
               
               
                   
                 1-yl 
               
               
                 74 
                 3-methylsulfonyl)-benzene 
                 3-hydroxyphenylmethyl 
                 568.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 75 
                 2-methylsulfonyl-benzene 
                 3-hydroxyphenylmethyl 
                 568.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 76 
                 3-cyano-benzene 
                 3-hydroxyphenylmethyl 
                 515.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 77 
                 6-quinoline carboxamido 
                 3-hydroxyphenylmethyl 
                 541.6 
               
               
                 78 
                 1-ethyl,3-methyl-pyrazole 
                 3-hydroxyphenylmethyl 
                 522.6 
               
               
                   
                 5-carboxamido 
               
               
                 79 
                 4-morpholino-benzene 
                 3-hydroxyphenylmethyl 
                 575.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 80 
                 2-chloro-4-methylsulfonyl- 
                 3-hydroxyphenylmethyl 
                 603 
               
               
                   
                 benzene carboxamido-1-yl 
               
               
                 81 
                 4-(imidazol-1-yl)benzene 
                 3-hydroxyphenylmethyl 
                 556.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 82 
                 2-thiophene carboxamido- 
                 3-hydroxyphenylmethyl 
                 496.6 
               
               
                   
                 1-yl 
               
               
                 83 
                 1-tert-butyl,3-methyl- 
                 3-hydroxyphenylmethyl 
                 550.6 
               
               
                   
                 pyrazole 5-carboxamido 
               
               
                 84 
                 4-aminomethyl benzene 
                 3-hydroxyphenylmethyl 
                 519.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 85 
                 2-hydroxyl-isobutanamido 
                 3-hydroxyphenylmethyl 
                 472.6 
               
               
                 86 
                 cyclopropane carboxamido- 
                 3-hydroxyphenylmethyl 
                 454.6 
               
               
                   
                 1-yl 
               
               
                 87 
                 cyclopentane carboxamido- 
                 3-hydroxyphenylmethyl 
                 482.6 
               
               
                   
                 1-yl 
               
               
                 88 
                 2-cyclopentyl acetamido 
                 3-hydroxyphenylmethyl 
                 496.6 
               
               
                 89 
                 cyclohexane carboxamido- 
                 3-hydroxyphenylmethyl 
                 496.6 
               
               
                   
                 1-yl 
               
               
                 90 
                 4-(4-N-Boc-piperazinyl-1- 
                 3-hydroxyphenylmethyl 
                 674.8 
               
               
                   
                 yl)benzene carboxamido-1- 
               
               
                   
                 yl 
               
               
                 91 
                 4-(piperazinyl-1- 
                 3-hydroxyphenylmethyl 
                 574.6 
               
               
                   
                 yl)benzene carboxamido-1- 
               
               
                   
                 yl 
               
               
                 92 
                 2-Fluoro-6-chloro-benzene 
                 3-hydroxyphenylmethyl 
                 542.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 93 
                 1-amino-cyclohexane 
                 3-hydroxyphenylmethyl 
                 511.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 94 
                 2-methylthio-acetamido 
                 3-hydroxyphenylmethyl 
                 474.6 
               
               
                 95 
                 2-methoxy-acetamido 
                 3-hydroxyphenylmethyl 
                 458.5 
               
               
                 96 
                 1-allyl-cyclopentane 
                 3-hydroxyphenylmethyl 
                 522.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 97 
                 1-n-propyl-cyclopentane 
                 3-hydroxyphenylmethyl 
                 524.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 98 
                 1-allyl-cyclopropane 
                 3-hydroxyphenylmethyl 
                 494.6 
               
               
                   
                 carboxamido-1-yl 
               
               
                 99 
                 8-quinoline-sulfonamido 
                 3-hydroxyphenylmethyl 
                 577.6 
               
               
                 100 
                 4-nitro-benzene 
                 3-hydroxyphenylmethyl 
                 571.6 
               
               
                   
                 sulfonamido 
               
               
                 101 
                 1,4-di-methyl-2-chloro- 
                 3-hydroxyphenylmethyl 
                 579 
               
               
                   
                 pyrazole-3-sulfonamido 
               
               
                 102 
                 1,5-dimethyl-isooxazole 3- 
                 3-hydroxyphenylmethyl 
                 545.6 
               
               
                   
                 sulfonamido 
               
               
                 103 
                 1-methyl-imidazole 3- 
                 3-hydroxyphenylmethyl 
                 530.6 
               
               
                   
                 sulfonamido 
               
               
                 104 
                 benzene sulfonamido 
                 3-hydroxyphenylmethyl 
                 526.6 
               
               
                 105 
                 1,4-dimethyl pyrazole 3- 
                 3-hydroxyphenylmethyl 
                 544.6 
               
               
                   
                 sulfonamido 
               
               
                 106 
                 2-methylsulfonyl benzene 
                 3-hydroxyphenylmethyl 
                 604.7 
               
               
                   
                 sulfonamido-1-yl 
               
               
                 107 
                 cyclohexylamino 
                 3-hydroxyphenylmethyl 
                 468 
               
               
                 108 
                 iso-propylamino 
                 3-hydroxyphenylmethyl 
                 428 
               
               
                 109 
                 2,2-dimethylpropyl-amino 
                 3-hydroxyphenylmethyl 
                 584 
               
               
                 110 
                 cyclopentylamino 
                 3-hydroxyphenylmethyl 
                 454.5 
               
               
                 111 
                 cyclopropylmethylamino 
                 3-hydroxyphenylmethyl 
                 440.5 
               
               
                 112 
                 benzylamine 
                 3-hydroxyphenylmethyl 
                 476.5 
               
               
                 113 
                 2-furanmethylamino 
                 3-hydroxyphenylmethyl 
                 466.5 
               
               
                 114 
                 3-cyanophenylmethylamino 
                 3-hydroxyphenylmethyl 
                 501.5 
               
               
                 115 
                 2,2-dimethylpropyl-amino 
                 3-(hydroxy-4- 
                 470.6 
               
               
                   
                   
                 methylphenyl)methyl 
               
               
                 116 
                 2-pentylamino 
                 3-hydroxyphenylmethyl 
                 456.6 
               
               
                 117 
                 bis-cyclopropylmethyamino 
                 3-hydroxyphenylmethyl 
                 494.6 
               
               
                 118 
                 2-thiophenemethylamino 
                 3-hydroxyphenylmethyl 
                 482.6 
               
               
                 119 
                 2-methyl-propylamino 
                 3-hydroxyphenylmethyl 
                 556.6 
               
               
                   
               
             
          
         
       
     
     The following tables contain representative examples of the present invention. Each entry in each table is intended to be paired with the formula at the start of the table. 
     
       
         
               
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
             
             
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 I 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 II 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 III 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 IV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 V 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 IX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 X 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXIV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXVI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXVII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXVIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXIX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXXI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXXII 
               
               
                   
               
             
          
           
               
                 Ex # 
                 R2 
                 R3 
                 Ms 
               
               
                   
               
             
          
           
               
                 200 
                 H 
                 H 
                   
               
               
                 201 
                 H 
                 methyl 
               
               
                 202 
                 H 
                 ethyl 
               
               
                 203 
                 H 
                 n-propyl 
               
               
                 204 
                 H 
                 n-butyl 
               
               
                 205 
                 H 
                 n-pentyl 
               
               
                 206 
                 H 
                 n-hexanyl 
               
               
                 207 
                 H 
                 n-heptanyl 
               
               
                 208 
                 H 
                 isopropyl 
               
               
                 209 
                 H 
                 tert-butyl 
               
               
                 210 
                 H 
                 cyclopropyl 
               
               
                 211 
                 H 
                 cyclobutanyl 
               
               
                 212 
                 H 
                 cyclopentanyl 
               
               
                 213 
                 H 
                 cyclohexanyl 
               
               
                 214 
                 H 
                 cycloheptanyl 
               
               
                 215 
                 H 
                 phenyl 
               
               
                 216 
                 H 
                 phenylmethyl 
               
               
                 217 
                 H 
                 3-hydroxyphenyl 
               
               
                 218 
                 H 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 219 
                 H 
                 3-fluorophenyl 
               
               
                 220 
                 H 
                 3-chlorophenyl 
               
               
                 221 
                 H 
                 3-nitrophenyl 
               
               
                 222 
                 H 
                 3-aminophenyl 
               
               
                 223 
                 H 
                 3-methylsulfonamidephenyl 
               
               
                 224 
                 H 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 225 
                 H 
                 3-Ac—NHphenyl 
               
               
                 226 
                 H 
                 3-Boc—NHphenyl 
               
               
                 227 
                 H 
                 3-Cbz—NHphenyl 
               
               
                 228 
                 H 
                 3-aminomethylenephenyl 
               
               
                 229 
                 H 
                 3-aminoethylenephenyl 
               
               
                 230 
                 H 
                 3-cyanophenyl 
               
               
                 231 
                 H 
                 3-cyanomethylphenyl 
               
               
                 232 
                 H 
                 3-hydroxymethylenephenyl 
               
               
                 233 
                 H 
                 3-carboxylphenyl 
               
               
                 234 
                 H 
                 3-mercaptophenyl 
               
               
                 235 
                 H 
                 3-methoxyphenyl 
               
               
                 236 
                 H 
                 3,4-methylenedioxophenyl 
               
               
                 237 
                 H 
                 3-tetrazolephenyl 
               
               
                 238 
                 H 
                 3-aminosulfonylphenyl 
               
               
                 239 
                 H 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 240 
                 H 
                 3-ethylamino-sulfonylphenyl 
               
               
                 241 
                 H 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 242 
                 H 
                 3-methylsulfonylphenyl 
               
               
                 243 
                 H 
                 4-methoxyphenyl 
               
               
                 244 
                 H 
                 4-phenylphenyl 
               
               
                 245 
                 H 
                 (2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 246 
                 H 
                 (2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 247 
                 H 
                 (2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 248 
                 H 
                 (2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 249 
                 H 
                 (2-amino-sufonylphenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 250 
                 H 
                 (2-chlorophenyl)-phenyl 
               
               
                 251 
                 H 
                 (2-fluorophenyl)-phenyl 
               
               
                 252 
                 H 
                 (2,4-dichlorophenyl)-phenyl 
               
               
                 253 
                 H 
                 (2,6-dichlorophenyl)-phenyl 
               
               
                 254 
                 H 
                 (3,5-dichlorophenyl)-phenyl 
               
               
                 256 
                 H 
                 (2,3-dichlorophenyl)-phenyl 
               
               
                 257 
                 H 
                 (2-methylphenyl)-phenyl 
               
               
                 258 
                 H 
                 (2-tetrazole-phenyl)-phenyl 
               
               
                 259 
                 H 
                 (2-methoxy-phenyl)-phenyl 
               
               
                 260 
                 H 
                 (2-tmethyl-phenyl)-phenyl 
               
               
                 261 
                 H 
                 (2-formyl-phenyl)-phenyl 
               
               
                 262 
                 H 
                 (2-amino-phenyl)-phenyl 
               
               
                 263 
                 H 
                 (2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 264 
                 H 
                 (2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 265 
                 H 
                 (2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 266 
                 H 
                 (2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 267 
                 H 
                 (2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 268 
                 H 
                 (3-methylphenyl)-phenyl 
               
               
                 269 
                 H 
                 (3-isopropylphenyl)-phenyl 
               
               
                 270 
                 H 
                 (3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 271 
                 H 
                 (3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 272 
                 H 
                 (3-amino-phenyl)-phenyl 
               
               
                 273 
                 H 
                 (3-nitro-phenyl)-phenyl 
               
               
                 274 
                 H 
                 2-pyridyl 
               
               
                 275 
                 H 
                 3-pyridyl 
               
               
                 276 
                 H 
                 4-pyridyl 
               
               
                 277 
                 H 
                 3-amino-4-pyridyl 
               
               
                 278 
                 H 
                 3-hydroxy-4-pyridyl 
               
               
                 279 
                 H 
                 3-imidazole 
               
               
                 280 
                 H 
                 2-nitro-3-imidazole 
               
               
                 281 
                 H 
                 5-thiazole 
               
               
                 282 
                 H 
                 5-oxazole 
               
               
                 283 
                 H 
                 4-pyazole 
               
               
                 284 
                 H 
                 phenylethyl 
               
               
                 285 
                 H 
                 2-aminophenylethyl 
               
               
                 286 
                 H 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 287 
                 H 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 288 
                 H 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 289 
                 H 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 290 
                 H 
                 2-tetrazolephenylethyl 
               
               
                 291 
                 H 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 292 
                 H 
                 2-aminosulfonyl-phenylethyl 
               
               
                 293 
                 H 
                 2-methoxyphenylethyl 
               
               
                 294 
                 H 
                 3-aminophenylethyl 
               
               
                 295 
                 H 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 296 
                 H 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 297 
                 H 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 298 
                 H 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 299 
                 H 
                 3-tetrazolephenylethyl 
               
               
                 300 
                 H 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 301 
                 H 
                 3-aminosulfonyl-phenylethyl 
               
               
                 302 
                 H 
                 3-methoxyphenylethyl 
               
               
                 303 
                 methyl 
                 H 
               
               
                 304 
                 methyl 
                 methyl 
               
               
                 305 
                 methyl 
                 ethyl 
               
               
                 306 
                 methyl 
                 n-propyl 
               
               
                 307 
                 methyl 
                 n-butyl 
               
               
                 308 
                 methyl 
                 n-pentyl 
               
               
                 309 
                 methyl 
                 n-hexanyl 
               
               
                 310 
                 methyl 
                 n-heptanyl 
               
               
                 311 
                 methyl 
                 isopropyl 
               
               
                 312 
                 methyl 
                 tert-butyl 
               
               
                 313 
                 methyl 
                 cyclopropyl 
               
               
                 314 
                 methyl 
                 cyclobutanyl 
               
               
                 315 
                 methyl 
                 cyclpentanyl 
               
               
                 316 
                 methyl 
                 cyclohexanyl 
               
               
                 317 
                 methyl 
                 cycloheptanyl 
               
               
                 318 
                 methyl 
                 phenyl 
               
               
                 319 
                 methyl 
                 phenylmethyl 
               
               
                 320 
                 methyl 
                 3-hydroxyphenyl 
               
               
                 321 
                 methyl 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 322 
                 methyl 
                 3-fluorophenyl 
               
               
                 323 
                 methyl 
                 3-chlorophenyl 
               
               
                 324 
                 methyl 
                 3-nitrophenyl 
               
               
                 325 
                 methyl 
                 3-aminophenyl 
               
               
                 326 
                 methyl 
                 3-methylsulfonamidephenyl 
               
               
                 327 
                 methyl 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 328 
                 methyl 
                 3-Ac—NHphenyl 
               
               
                 329 
                 methyl 
                 3-Boc—NHphenyl 
               
               
                 330 
                 methyl 
                 3-Cbz—NHphenyl 
               
               
                 331 
                 Methyl 
                 3-aminomethylenephenyl 
               
               
                 332 
                 methyl 
                 3-aminoethylenephenyl 
               
               
                 333 
                 methyl 
                 3-cyanophenyl 
               
               
                 334 
                 methyl 
                 3-cyanomethylphenyl 
               
               
                 335 
                 methyl 
                 3-hydroxymethylenephenyl 
               
               
                 336 
                 methyl 
                 3-carboxylphenyl 
               
               
                 337 
                 methyl 
                 3-mercaptophenyl 
               
               
                 338 
                 methyl 
                 3-methoxyphenyl 
               
               
                 339 
                 methyl 
                 3,4-methylenedioxophenyl 
               
               
                 340 
                 methyl 
                 3-tetrazolephenyl 
               
               
                 341 
                 methyl 
                 3-aminosulfonylphenyl 
               
               
                 342 
                 methyl 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 343 
                 methyl 
                 3-ethylamino-sulfonylphenyl 
               
               
                 344 
                 methyl 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 345 
                 methyl 
                 3-methylsulfonylphenyl 
               
               
                 346 
                 methyl 
                 4-methoxyphenyl 
               
               
                 347 
                 methyl 
                 4-phenylphenyl 
               
               
                 348 
                 methyl 
                 (2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 349 
                 methyl 
                 (2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 350 
                 methyl 
                 (2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 351 
                 methyl 
                 (2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 352 
                 methyl 
                 (2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 353 
                 methyl 
                 (2-chlorophenyl)-phenyl 
               
               
                 354 
                 methyl 
                 (2-fluorophenyl)-phenyl 
               
               
                 355 
                 methyl 
                 (2,4-dichlorophenyl)-phenyl 
               
               
                 356 
                 methyl 
                 (2,6-dichlorophenyl)-phenyl 
               
               
                 357 
                 methyl 
                 (3,5-dichlorophenyl)-phenyl 
               
               
                 358 
                 methyl 
                 (2,3-dichlorophenyl)-phenyl 
               
               
                 359 
                 methyl 
                 (2-methylphenyl)-phenyl 
               
               
                 360 
                 methyl 
                 (2-tetrazole-phenyl)-phenyl 
               
               
                 361 
                 methyl 
                 (2-methoxy-phenyl)-phenyl 
               
               
                 362 
                 methyl 
                 (2-tmethyl-phenyl)-phenyl 
               
               
                 363 
                 methyl 
                 (2-formyl-phenyl)-phenyl 
               
               
                 364 
                 methyl 
                 (2-amino-phenyl)-phenyl 
               
               
                 365 
                 methyl 
                 (2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 366 
                 methyl 
                 (2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 367 
                 methyl 
                 (2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 368 
                 methyl 
                 (2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 369 
                 methyl 
                 (2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 370 
                 methyl 
                 (3-methylphenyl)-phenyl 
               
               
                 371 
                 methyl 
                 (3-isopropylphenyl)-phenyl 
               
               
                 372 
                 methyl 
                 (3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 373 
                 methyl 
                 (3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 374 
                 methyl 
                 (3-amino-phenyl)-phenyl 
               
               
                 375 
                 methyl 
                 (3-nitro-phenyl)-phenyl 
               
               
                 376 
                 methyl 
                 2-pyridyl 
               
               
                 377 
                 methyl 
                 3-pyridyl 
               
               
                 378 
                 methyl 
                 4-pyridyl 
               
               
                 379 
                 methyl 
                 3-amino-4-pyridyl 
               
               
                 380 
                 methyl 
                 3-hydroxy-4-pyridyl 
               
               
                 381 
                 methyl 
                 3-imidazole 
               
               
                 382 
                 methyl 
                 2-nitro-3-imidazole 
               
               
                 383 
                 methyl 
                 5-thiazole 
               
               
                 384 
                 methyl 
                 5-oxazole 
               
               
                 385 
                 methyl 
                 4-pyazole 
               
               
                 386 
                 methyl 
                 phenylethyl 
               
               
                 387 
                 methyl 
                 2-aminophenylethyl 
               
               
                 388 
                 methyl 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 389 
                 methyl 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 390 
                 methyl 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 391 
                 methyl 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 392 
                 methyl 
                 2-tetrazolephenylethyl 
               
               
                 393 
                 methyl 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 394 
                 methyl 
                 2-aminosulfonyl-phenylethyl 
               
               
                 395 
                 methyl 
                 2-methoxyphenylethyl 
               
               
                 396 
                 methyl 
                 3-aminophenylethyl 
               
               
                 397 
                 methyl 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 398 
                 methyl 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 399 
                 methyl 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 400 
                 methyl 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 401 
                 methyl 
                 3-tetrazolephenylethyl 
               
               
                 402 
                 methyl 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 403 
                 methyl 
                 3-aminosulfonyl-phenylethyl 
               
               
                 404 
                 methyl 
                 3-methoxyphenylethyl 
               
               
                 405 
                 OH 
                 H 
               
               
                 406 
                 OH 
                 methyl 
               
               
                 407 
                 OH 
                 ethyl 
               
               
                 408 
                 OH 
                 n-propyl 
               
               
                 409 
                 OH 
                 n-butyl 
               
               
                 410 
                 OH 
                 n-pentyl 
               
               
                 411 
                 OH 
                 n-hexanyl 
               
               
                 412 
                 OH 
                 n-heptanyl 
               
               
                 413 
                 OH 
                 isopropyl 
               
               
                 414 
                 OH 
                 tert-butyl 
               
               
                 415 
                 OH 
                 cyclopropyl 
               
               
                 416 
                 OH 
                 cyclobutanyl 
               
               
                 417 
                 OH 
                 cyclpentanyl 
               
               
                 418 
                 OH 
                 cyclohexanyl 
               
               
                 419 
                 OH 
                 cycloheptanyl 
               
               
                 420 
                 OH 
                 phenyl 
               
               
                 421 
                 OH 
                 phenylmethyl 
               
               
                 422 
                 OH 
                 3-hydroxyphenyl 
               
               
                 423 
                 OH 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 424 
                 OH 
                 3-fluorophenyl 
               
               
                 425 
                 OH 
                 3-chlorophenyl 
               
               
                 426 
                 OH 
                 3-nitrophenyl 
               
               
                 427 
                 OH 
                 3-aminophenyl 
               
               
                 428 
                 OH 
                 3-methylsulfonamidephenyl 
               
               
                 429 
                 OH 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 430 
                 OH 
                 3-Ac—NHphenyl 
               
               
                 431 
                 OH 
                 3-Boc—NHphenyl 
               
               
                 432 
                 OH 
                 3-Cbz—NHphenyl 
               
               
                 433 
                 OH 
                 3-aminomethylenephenyl 
               
               
                 434 
                 OH 
                 3-aminoethylenephenyl 
               
               
                 435 
                 OH 
                 3-cyanophenyl 
               
               
                 436 
                 OH 
                 3-cyanomethylphenyl 
               
               
                 437 
                 OH 
                 3-hydroxymethylenephenyl 
               
               
                 438 
                 OH 
                 3-carboxylphenyl 
               
               
                 439 
                 OH 
                 3-mercaptophenyl 
               
               
                 440 
                 OH 
                 3-methoxyphenyl 
               
               
                 441 
                 OH 
                 3,4-methylenedioxophenyl 
               
               
                 442 
                 OH 
                 3-tetrazolephenyl 
               
               
                 443 
                 OH 
                 3-aminosulfonylphenyl 
               
               
                 444 
                 OH 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 445 
                 OH 
                 3-ethylamino-sulfonylphenyl 
               
               
                 446 
                 OH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 447 
                 OH 
                 3-methylsulfonylphenyl 
               
               
                 448 
                 OH 
                 4-methoxyphenyl 
               
               
                 449 
                 OH 
                 4-phenylphenyl 
               
               
                 450 
                 OH 
                 (2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 451 
                 OH 
                 (2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 452 
                 OH 
                 (2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 453 
                 OH 
                 (2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 454 
                 OH 
                 (2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 455 
                 OH 
                 (2-chlorophenyl)-phenyl 
               
               
                 456 
                 OH 
                 (2-fluorophenyl)-phenyl 
               
               
                 457 
                 OH 
                 (2,4-dichlorophenyl)-phenyl 
               
               
                 458 
                 OH 
                 (2,6-dichlorophenyl)-phenyl 
               
               
                 459 
                 OH 
                 (3,5-dichlorophenyl)-phenyl 
               
               
                 460 
                 OH 
                 (2,3-dichlorophenyl)-phenyl 
               
               
                 461 
                 OH 
                 (2-methylphenyl)-phenyl 
               
               
                 462 
                 OH 
                 (2-tetrazole-phenyl)-phenyl 
               
               
                 463 
                 OH 
                 (2-methoxy-phenyl)-phenyl 
               
               
                 464 
                 OH 
                 (2-tmethyl-phenyl)-phenyl 
               
               
                 465 
                 OH 
                 (2-formyl-phenyl)-phenyl 
               
               
                 466 
                 OH 
                 (2-amino-phenyl)-phenyl 
               
               
                 467 
                 OH 
                 (2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 468 
                 OH 
                 (2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 469 
                 OH 
                 (2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 470 
                 OH 
                 (2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 471 
                 OH 
                 (2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 472 
                 OH 
                 (3-methylphenyl)-phenyl 
               
               
                 473 
                 OH 
                 (3-isopropylphenyl)-phenyl 
               
               
                 474 
                 OH 
                 (3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 475 
                 OH 
                 (3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 476 
                 OH 
                 (3-amino-phenyl)-phenyl 
               
               
                 477 
                 OH 
                 (3-nitro-phenyl)-phenyl 
               
               
                 478 
                 OH 
                 2-pyridyl 
               
               
                 479 
                 OH 
                 3-pyridyl 
               
               
                 480 
                 OH 
                 4-pyridyl 
               
               
                 481 
                 OH 
                 3-amino-4-pyridyl 
               
               
                 482 
                 OH 
                 3-hydroxy-4-pyridyl 
               
               
                 483 
                 OH 
                 3-imidazole 
               
               
                 484 
                 OH 
                 2-nitro-3-imidazole 
               
               
                 485 
                 OH 
                 5-thiazole 
               
               
                 486 
                 OH 
                 5-oxazole 
               
               
                 487 
                 OH 
                 4-pyazole 
               
               
                 488 
                 OH 
                 phenylethyl 
               
               
                 489 
                 OH 
                 2-aminophenylethyl 
               
               
                 490 
                 OH 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 491 
                 OH 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 492 
                 OH 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 493 
                 OH 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 494 
                 OH 
                 2-tetrazolephenylethyl 
               
               
                 495 
                 OH 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 496 
                 OH 
                 2-aminosulfonyl-phenylethyl 
               
               
                 497 
                 OH 
                 2-methoxyphenylethyl 
               
               
                 498 
                 OH 
                 3-aminophenylethyl 
               
               
                 499 
                 OH 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 500 
                 OH 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 501 
                 OH 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 502 
                 OH 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 503 
                 OH 
                 3-tetrazolephenylethyl 
               
               
                 504 
                 OH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 505 
                 OH 
                 3-aminosulfonyl-phenylethyl 
               
               
                 506 
                 OH 
                 3-methoxyphenylethyl 
               
               
                 507 
                 NH(CO)CH 3   
                 H 
               
               
                 508 
                 NH(CO)CH 3   
                 methyl 
               
               
                 509 
                 NH(CO)CH 3   
                 ethyl 
               
               
                 510 
                 NH(CO)CH 3   
                 n-propyl 
               
               
                 511 
                 NH(CO)CH 3   
                 n-butyl 
               
               
                 512 
                 NH(CO)CH 3   
                 n-pentyl 
               
               
                 513 
                 NH(CO)CH 3   
                 n-hexanyl 
               
               
                 514 
                 NH(CO)CH 3   
                 n-heptanyl 
               
               
                 515 
                 NH(CO)CH 3   
                 isopropyl 
               
               
                 516 
                 NH(CO)CH 3   
                 tert-butyl 
               
               
                 517 
                 NH(CO)CH 3   
                 cyclopropyl 
               
               
                 518 
                 NH(CO)CH 3   
                 cyclobutanyl 
               
               
                 519 
                 NH(CO)CH 3   
                 cyclpentanyl 
               
               
                 520 
                 NH(CO)CH 3   
                 cyclohexanyl 
               
               
                 521 
                 NH(CO)CH 3   
                 cycloheptanyl 
               
               
                 522 
                 NH(CO)CH 3   
                 phenyl 
               
               
                 523 
                 NH(CO)CH 3   
                 phenylmethyl 
               
               
                 524 
                 NH(CO)CH 3   
                 3-hydroxyphenyl 
               
               
                 525 
                 NH(CO)CH 3   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 526 
                 NH(CO)CH 3   
                 3-fluorophenyl 
               
               
                 527 
                 NH(CO)CH 3   
                 3-chlorophenyl 
               
               
                 528 
                 NH(CO)CH 3   
                 3-nitrophenyl 
               
               
                 529 
                 NH(CO)CH 3   
                 3-aminophenyl 
               
               
                 530 
                 NH(CO)CH 3   
                 3-methyl-sulfonamidephenyl 
               
               
                 531 
                 NH(CO)CH 3   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 532 
                 NH(CO)CH 3   
                 3-Ac—NHphenyl 
               
               
                 533 
                 NH(CO)CH 3   
                 3-Boc—NHphenyl 
               
               
                 534 
                 NH(CO)CH 3   
                 3-Cbz—NHphenyl 
               
               
                 535 
                 NH(CO)CH 3   
                 3-aminomethylenephenyl 
               
               
                 536 
                 NH(CO)CH 3   
                 3-aminoethylenephenyl 
               
               
                 537 
                 NH(CO)CH 3   
                 3-cyanophenyl 
               
               
                 538 
                 NH(CO)CH 3   
                 3-cyanomethylphenyl 
               
               
                 539 
                 NH(CO)CH 3   
                 3-hydroxymethylenephenyl 
               
               
                 540 
                 NH(CO)CH 3   
                 3-carboxylphenyl 
               
               
                 541 
                 NH(CO)CH 3   
                 3-mercaptophenyl 
               
               
                 542 
                 NH(CO)CH 3   
                 3-methoxyphenyl 
               
               
                 543 
                 NH(CO)CH 3   
                 3,4-methylenedioxophenyl 
               
               
                 544 
                 NH(CO)CH 3   
                 3-tetrazolephenyl 
               
               
                 545 
                 NH(CO)CH 3   
                 3-aminosulfonylphenyl 
               
               
                 546 
                 NH(CO)CH 3   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 547 
                 NH(CO)CH 3   
                 3-ethylamino-sulfonylphenyl 
               
               
                 548 
                 NH(CO)CH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 549 
                 NH(CO)CH 3   
                 3-methylsulfonylphenyl 
               
               
                 550 
                 NH(CO)CH 3   
                 4-methoxyphenyl 
               
               
                 551 
                 NH(CO)CH 3   
                 4-phenylphenyl 
               
               
                 552 
                 NH(CO)CH 3   
                 (2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 553 
                 NH(CO)CH 3   
                 (2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 554 
                 NH(CO)CH 3   
                 (2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 555 
                 NH(CO)CH 3   
                 (2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 556 
                 NH(CO)CH 3   
                 (2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 557 
                 NH(CO)CH 3   
                 (2-chlorophenyl)-phenyl 
               
               
                 558 
                 NH(CO)CH 3   
                 (2-fluorophenyl)-phenyl 
               
               
                 559 
                 NH(CO)CH 3   
                 (2,4-dichlorophenyl)-phenyl 
               
               
                 560 
                 NH(CO)CH 3   
                 (2,6-dichlorophenyl)-phenyl 
               
               
                 561 
                 NH(CO)CH 3   
                 (3,5-dichlorophenyl)-phenyl 
               
               
                 562 
                 NH(CO)CH 3   
                 (2,3-dichlorophenyl)-phenyl 
               
               
                 563 
                 NH(CO)CH 3   
                 (2-methylphenyl)-phenyl 
               
               
                 564 
                 NH(CO)CH 3   
                 (2-tetrazole-phenyl)-phenyl 
               
               
                 565 
                 NH(CO)CH 3   
                 (2-methoxy-phenyl)-phenyl 
               
               
                 566 
                 NH(CO)CH 3   
                 (2-tmethyl-phenyl)-phenyl 
               
               
                 567 
                 NH(CO)CH 3   
                 (2-formyl-phenyl)-phenyl 
               
               
                 568 
                 NH(CO)CH 3   
                 (2-amino-phenyl)-phenyl 
               
               
                 569 
                 NH(CO)CH 3   
                 (2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 570 
                 NH(CO)CH 3   
                 (2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 571 
                 NH(CO)CH 3   
                 (2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 572 
                 NH(CO)CH 3   
                 (2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 573 
                 NH(CO)CH 3   
                 (2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 574 
                 NH(CO)CH 3   
                 (3-methylphenyl)-phenyl 
               
               
                 575 
                 NH(CO)CH 3   
                 (3-isopropylphenyl)-phenyl 
               
               
                 576 
                 NH(CO)CH 3   
                 (3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 577 
                 NH(CO)CH 3   
                 (3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 578 
                 NH(CO)CH 3   
                 (3-amino-phenyl)-phenyl 
               
               
                 579 
                 NH(CO)CH 3   
                 (3-nitro-phenyl)-phenyl 
               
               
                 580 
                 NH(CO)CH 3   
                 2-pyridyl 
               
               
                 581 
                 NH(CO)CH 3   
                 3-pyridyl 
               
               
                 582 
                 NH(CO)CH 3   
                 4-pyridyl 
               
               
                 583 
                 NH(CO)CH 3   
                 3-amino-4-pyridyl 
               
               
                 584 
                 NH(CO)CH 3   
                 3-hydroxy-4-pyridyl 
               
               
                 585 
                 NH(CO)CH 3   
                 3-imidazole 
               
               
                 586 
                 NH(CO)CH 3   
                 2-nitro-3-imidazole 
               
               
                 587 
                 NH(CO)CH 3   
                 5-thiazole 
               
               
                 588 
                 NH(CO)CH 3   
                 5-oxazole 
               
               
                 589 
                 NH(CO)CH 3   
                 4-pyazole 
               
               
                 590 
                 NH(CO)CH 3   
                 phenylethyl 
               
               
                 591 
                 NH(CO)CH 3   
                 2-aminophenylethyl 
               
               
                 592 
                 NH(CO)CH 3   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 593 
                 NH(CO)CH 3   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 594 
                 NH(CO)CH 3   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 595 
                 NH(CO)CH 3   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 596 
                 NH(CO)CH 3   
                 2-tetrazolephenylethyl 
               
               
                 597 
                 NH(CO)CH 3   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 598 
                 NH(CO)CH 3   
                 2-aminosulfonyl-phenylethyl 
               
               
                 599 
                 NH(CO)CH 3   
                 2-methoxyphenylethyl 
               
               
                 600 
                 NH(CO)CH 3   
                 3-aminophenylethyl 
               
               
                 601 
                 NH(CO)CH 3   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 602 
                 NH(CO)CH 3   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 603 
                 NH(CO)CH 3   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 604 
                 NH(CO)CH 3   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 605 
                 NH(CO)CH 3   
                 3-tetrazolephenylethyl 
               
               
                 606 
                 NH(CO)CH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 607 
                 NH(CO)CH 3   
                 3-aminosulfonyl-phenylethyl 
               
               
                 608 
                 NH(CO)CH 3   
                 3-methoxyphenylethyl 
               
               
                 609 
               
               
                 610 
                 NH(CO)C 2 H 5   
                 H 
               
               
                 611 
                 NH(CO)C 2 H 5   
                 methyl 
               
               
                 612 
                 NH(CO)C 2 H 5   
                 ethyl 
               
               
                 613 
                 NH(CO)C 2 H 5   
                 n-propyl 
               
               
                 614 
                 NH(CO)C 2 H 5   
                 n-butyl 
               
               
                 615 
                 NH(CO)C 2 H 5   
                 n-pentyl 
               
               
                 616 
                 NH(CO)C 2 H 5   
                 n-hexanyl 
               
               
                 617 
                 NH(CO)C 2 H 5   
                 n-heptanyl 
               
               
                 618 
                 NH(CO)C 2 H 5   
                 isopropyl 
               
               
                 619 
                 NH(CO)C 2 H 5   
                 tert-butyl 
               
               
                 620 
                 NH(CO)C 2 H 5   
                 cyclopropyl 
               
               
                 621 
                 NH(CO)C 2 H 5   
                 cyclobutanyl 
               
               
                 622 
                 NH(CO)C 2 H 5   
                 cyclpentanyl 
               
               
                 623 
                 NH(CO)C 2 H 5   
                 cyclohexanyl 
               
               
                 624 
                 NH(CO)C 2 H 5   
                 cycloheptanyl 
               
               
                 625 
                 NH(CO)C 2 H 5   
                 phenyl 
               
               
                 626 
                 NH(CO)C 2 H 5   
                 phenylmethyl 
               
               
                 627 
                 NH(CO)C 2 H 5   
                 3-hydroxyphenyl 
               
               
                 628 
                 NH(CO)C 2 H 5   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 629 
                 NH(CO)C 2 H 5   
                 3-fluorophenyl 
               
               
                 630 
                 NH(CO)C 2 H 5   
                 3-chlorophenyl 
               
               
                 631 
                 NH(CO)C 2 H 5   
                 3-nitrophenyl 
               
               
                 632 
                 NH(CO)C 2 H 5   
                 3-aminophenyl 
               
               
                 633 
                 NH(CO)C 2 H 5   
                 3-methylsulfonamidephenyl 
               
               
                 634 
                 NH(CO)C 2 H 5   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 635 
                 NH(CO)C 2 H 5   
                 3-Ac—NHphenyl 
               
               
                 636 
                 NH(CO)C 2 H 5   
                 3-Boc—NHphenyl 
               
               
                 637 
                 NH(CO)C 2 H 5   
                 3-Cbz—NHphenyl 
               
               
                 638 
                 NH(CO)C 2 H 5   
                 3-aminomethylenephenyl 
               
               
                 639 
                 NH(CO)C 2 H 5   
                 3-aminoethylenephenyl 
               
               
                 640 
                 NH(CO)C 2 H 5   
                 3-cyanophenyl 
               
               
                 641 
                 NH(CO)C 2 H 5   
                 3-cyanomethylphenyl 
               
               
                 642 
                 NH(CO)C 2 H 5   
                 3-hydroxymethylenephenyl 
               
               
                 643 
                 NH(CO)C 2 H 5   
                 3-carboxylphenyl 
               
               
                 644 
                 NH(CO)C 2 H 5   
                 3-mercaptophenyl 
               
               
                 645 
                 NH(CO)C 2 H 5   
                 3-methoxyphenyl 
               
               
                 646 
                 NH(CO)C 2 H 5   
                 3,4-methylenedioxophenyl 
               
               
                 647 
                 NH(CO)C 2 H 5   
                 3-tetrazolephenyl 
               
               
                 648 
                 NH(CO)C 2 H 5   
                 3-aminosulfonylphenyl 
               
               
                 649 
                 NH(CO)C 2 H 5   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 650 
                 NH(CO)C 2 H 5   
                 3-ethylamino-sulfonylphenyl 
               
               
                 651 
                 NH(CO)C 2 H 5   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 652 
                 NH(CO)C 2 H 5   
                 3-methylsulfonylphenyl 
               
               
                 653 
                 NH(CO)C 2 H 5   
                 4-methoxyphenyl 
               
               
                 654 
                 NH(CO)C 2 H 5   
                 4-phenylphenyl 
               
               
                 655 
                 NH(CO)C 2 H 5   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 656 
                 NH(CO)C 2 H 5   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 657 
                 NH(CO)C 2 H 5   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 658 
                 NH(CO)C 2 H 5   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 659 
                 NH(CO)C 2 H 5   
                 4-(2-amino-sufonylphenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 660 
                 NH(CO)C 2 H 5   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 661 
                 NH(CO)C 2 H 5   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 662 
                 NH(CO)C 2 H 5   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 663 
                 NH(CO)C 2 H 5   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 664 
                 NH(CO)C 2 H 5   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 665 
                 NH(CO)C 2 H 5   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 666 
                 NH(CO)C 2 H 5   
                 4-(2-methylphenyl)-phenyl 
               
               
                 667 
                 NH(CO)C 2 H 5   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 668 
                 NH(CO)C 2 H 5   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 669 
                 NH(CO)C 2 H 5   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 670 
                 NH(CO)C 2 H 5   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 671 
                 NH(CO)C 2 H 5   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 672 
                 NH(CO)C 2 H 5   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 673 
                 NH(CO)C 2 H 5   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 674 
                 NH(CO)C 2 H 5   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 675 
                 NH(CO)C 2 H 5   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 676 
                 NH(CO)C 2 H 5   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 677 
                 NH(CO)C 2 H 5   
                 4-(3-methylphenyl)-phenyl 
               
               
                 678 
                 NH(CO)C 2 H 5   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 679 
                 NH(CO)C 2 H 5   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 680 
                 NH(CO)C 2 H 5   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 681 
                 NH(CO)C 2 H 5   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 682 
                 NH(CO)C 2 H 5   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 683 
                 NH(CO)C 2 H 5   
                 2-pyridyl 
               
               
                 684 
                 NH(CO)C 2 H 5   
                 3-pyridyl 
               
               
                 685 
                 NH(CO)C 2 H 5   
                 4-pyridyl 
               
               
                 686 
                 NH(CO)C 2 H 5   
                 3-amino-4-pyridyl 
               
               
                 687 
                 NH(CO)C 2 H 5   
                 3-hydroxy-4-pyridyl 
               
               
                 688 
                 NH(CO)C 2 H 5   
                 3-imidazole 
               
               
                 689 
                 NH(CO)C 2 H 5   
                 2-nitro-3-imidazole 
               
               
                 690 
                 NH(CO)C 2 H 5   
                 5-thiazole 
               
               
                 691 
                 NH(CO)C 2 H 5   
                 5-oxazole 
               
               
                 692 
                 NH(CO)C 2 H 5   
                 4-pyazole 
               
               
                 693 
                 NH(CO)C 2 H 5   
                 phenylethyl 
               
               
                 694 
                 NH(CO)C 2 H 5   
                 2-aminophenylethyl 
               
               
                 695 
                 NH(CO)C 2 H 5   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 696 
                 NH(CO)C 2 H 5   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 697 
                 NH(CO)C 2 H 5   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 698 
                 NH(CO)C 2 H 5   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 699 
                 NH(CO)C 2 H 5   
                 2-tetrazolephenylethyl 
               
               
                 700 
                 NH(CO)C 2 H 5   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 701 
                 NH(CO)C 2 H 5   
                 2-aminosulfonyl-phenylethyl 
               
               
                 702 
                 NH(CO)C 2 H 5   
                 2-methoxyphenylethyl 
               
               
                 703 
                 NH(CO)C 2 H 5   
                 3-aminophenylethyl 
               
               
                 704 
                 NH(CO)C 2 H 5   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 705 
                 NH(CO)C 2 H 5   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 706 
                 NH(CO)C 2 H 5   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 707 
                 NH(CO)C 2 H 5   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 708 
                 NH(CO)C 2 H 5   
                 3-tetrazolephenylethyl 
               
               
                 709 
                 NH(CO)C 2 H 5   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 710 
                 NH(CO)C 2 H 5   
                 3-aminosulfonyl-phenylethyl 
               
               
                 711 
                 NH(CO)C 2 H 5   
                 3-methoxyphenylethyl 
               
               
                 712 
                 NH(CO)OC 2 H 5   
                 H 
               
               
                 713 
                 NH(CO)OC 2 H 5   
                 methyl 
               
               
                 714 
                 NH(CO)OC 2 H 5   
                 ethyl 
               
               
                 715 
                 NH(CO)OC 2 H 5   
                 n-propyl 
               
               
                 716 
                 NH(CO)OC 2 H 5   
                 n-butyl 
               
               
                 717 
                 NH(CO)OC 2 H 5   
                 n-pentyl 
               
               
                 718 
                 NH(CO)OC 2 H 5   
                 n-hexanyl 
               
               
                 719 
                 NH(CO)OC 2 H 5   
                 n-heptanyl 
               
               
                 720 
                 NH(CO)OC 2 H 5   
                 isopropyl 
               
               
                 721 
                 NH(CO)OC 2 H 5   
                 tert-butyl 
               
               
                 722 
                 NH(CO)OC 2 H 5   
                 cyclopropyl 
               
               
                 723 
                 NH(CO)OC 2 H 5   
                 cyclobutanyl 
               
               
                 724 
                 NH(CO)OC 2 H 5   
                 cyclpentanyl 
               
               
                 725 
                 NH(CO)OC 2 H 5   
                 cyclohexanyl 
               
               
                 726 
                 NH(CO)OC 2 H 5   
                 cycloheptanyl 
               
               
                 727 
                 NH(CO)OC 2 H 5   
                 phenyl 
               
               
                 728 
                 NH(CO)OC 2 H 5   
                 phenylmethyl 
               
               
                 729 
                 NH(CO)OC 2 H 5   
                 3-hydroxyphenyl 
               
               
                 730 
                 NH(CO)OC 2 H 5   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 731 
                 NH(CO)OC 2 H 5   
                 3-fluorophenyl 
               
               
                 732 
                 NH(CO)OC 2 H 5   
                 3-chlorophenyl 
               
               
                 733 
                 NH(CO)OC 2 H 5   
                 3-nitrophenyl 
               
               
                 734 
                 NH(CO)OC 2 H 5   
                 3-aminophenyl 
               
               
                 735 
                 NH(CO)OC 2 H 5   
                 3-methyl-sulfonamidephenyl 
               
               
                 736 
                 NH(CO)OC 2 H 5   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 737 
                 NH(CO)OC 2 H 5   
                 3-Ac—NHphenyl 
               
               
                 738 
                 NH(CO)OC 2 H 5   
                 3-Boc—NHphenyl 
               
               
                 739 
                 NH(CO)OC 2 H 5   
                 3-Cbz—NHphenyl 
               
               
                 740 
                 NH(CO)OC 2 H 5   
                 3-aminomethylenephenyl 
               
               
                 741 
                 NH(CO)OC 2 H 5   
                 3-aminoethylenephenyl 
               
               
                 742 
                 NH(CO)OC 2 H 5   
                 3-cyanophenyl 
               
               
                 743 
                 NH(CO)OC 2 H 5   
                 3-cyanomethylphenyl 
               
               
                 744 
                 NH(CO)OC 2 H 5   
                 3-hydroxymethylenephenyl 
               
               
                 745 
                 NH(CO)OC 2 H 5   
                 3-carboxylphenyl 
               
               
                 746 
                 NH(CO)OC 2 H 5   
                 3-mercaptophenyl 
               
               
                 747 
                 NH(CO)OC 2 H 5   
                 3-methoxyphenyl 
               
               
                 748 
                 NH(CO)OC 2 H 5   
                 3,4-methylenedioxophenyl 
               
               
                 749 
                 NH(CO)OC 2 H 5   
                 3-tetrazolephenyl 
               
               
                 750 
                 NH(CO)OC 2 H 5   
                 3-aminosulfonylphenyl 
               
               
                 751 
                 NH(CO)OC 2 H 5   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 752 
                 NH(CO)OC 2 H 5   
                 3-ethylamino-sulfonylphenyl 
               
               
                 753 
                 NH(CO)OC 2 H 5   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 754 
                 NH(CO)OC 2 H 5   
                 3-methylsulfonylphenyl 
               
               
                 755 
                 NH(CO)OC 2 H 5   
                 4-methoxyphenyl 
               
               
                 756 
                 NH(CO)OC 2 H 5   
                 4-phenylphenyl 
               
               
                 757 
                 NH(CO)OC 2 H 5   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 758 
                 NH(CO)OC 2 H 5   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 759 
                 NH(CO)OC 2 H 5   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 760 
                 NH(CO)OC 2 H 5   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 761 
                 NH(CO)OC 2 H 5   
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 762 
                 NH(CO)OC 2 H 5   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 763 
                 NH(CO)OC 2 H 5   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 764 
                 NH(CO)OC 2 H 5   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 765 
                 NH(CO)OC 2 H 5   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 766 
                 NH(CO)OC 2 H 5   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 767 
                 NH(CO)OC 2 H 5   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 768 
                 NH(CO)OC 2 H 5   
                 4-(2-methylphenyl)-phenyl 
               
               
                 769 
                 NH(CO)OC 2 H 5   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 770 
                 NH(CO)OC 2 H 5   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 771 
                 NH(CO)OC 2 H 5   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 772 
                 NH(CO)OC 2 H 5   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 773 
                 NH(CO)OC 2 H 5   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 774 
                 NH(CO)OC 2 H 5   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 775 
                 NH(CO)OC 2 H 5   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 776 
                 NH(CO)OC 2 H 5   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 777 
                 NH(CO)OC 2 H 5   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 778 
                 NH(CO)OC 2 H 5   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 779 
                 NH(CO)OC 2 H 5   
                 4-(3-methylphenyl)-phenyl 
               
               
                 780 
                 NH(CO)OC 2 H 5   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 781 
                 NH(CO)OC 2 H 5   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 782 
                 NH(CO)OC 2 H 5   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 783 
                 NH(CO)OC 2 H 5   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 784 
                 NH(CO)OC 2 H 5   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 785 
                 NH(CO)OC 2 H 5   
                 2-pyridyl 
               
               
                 786 
                 NH(CO)OC 2 H 5   
                 3-pyridyl 
               
               
                 787 
                 NH(CO)OC 2 H 5   
                 4-pyridyl 
               
               
                 788 
                 NH(CO)OC 2 H 5   
                 3-amino-4-pyridyl 
               
               
                 789 
                 NH(CO)OC 2 H 5   
                 3-hydroxy-4-pyridyl 
               
               
                 790 
                 NH(CO)OC 2 H 5   
                 3-imidazole 
               
               
                 791 
                 NH(CO)OC 2 H 5   
                 2-nitro-3-imidazole 
               
               
                 792 
                 NH(CO)OC 2 H 5   
                 5-thiazole 
               
               
                 793 
                 NH(CO)OC 2 H 5   
                 5-oxazole 
               
               
                 794 
                 NH(CO)OC 2 H 5   
                 4-pyazole 
               
               
                 795 
                 NH(CO)OC 2 H 5   
                 phenylethyl 
               
               
                 796 
                 NH(CO)OC 2 H 5   
                 2-aminophenylethyl 
               
               
                 797 
                 NH(CO)OC 2 H 5   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 798 
                 NH(CO)OC 2 H 5   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 799 
                 NH(CO)OC 2 H 5   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 800 
                 NH(CO)OC 2 H 5   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 801 
                 NH(CO)OC 2 H 5   
                 2-tetrazolephenylethyl 
               
               
                 802 
                 NH(CO)OC 2 H 5   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 803 
                 NH(CO)OC 2 H 5   
                 2-aminosulfonyl-phenylethyl 
               
               
                 804 
                 NH(CO)OC 2 H 5   
                 2-methoxyphenylethyl 
               
               
                 805 
                 NH(CO)OC 2 H 5   
                 3-aminophenylethyl 
               
               
                 806 
                 NH(CO)OC 2 H 5   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 807 
                 NH(CO)OC 2 H 5   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 808 
                 NH(CO)OC 2 H 5   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 809 
                 NH(CO)OC 2 H 5   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 810 
                 NH(CO)OC 2 H 5   
                 3-tetrazolephenylethyl 
               
               
                 811 
                 NH(CO)OC 2 H 5   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 812 
                 NH(CO)OC 2 H 5   
                 3-aminosulfonyl-phenylethyl 
               
               
                 813 
                 NH(CO)OC 2 H 5   
                 3-methoxyphenylethyl 
               
               
                 814 
                 NH(CO)OCH 3   
                 H 
               
               
                 815 
                 NH(CO)OCH 3   
                 methyl 
               
               
                 816 
                 NH(CO)OCH 3   
                 ethyl 
               
               
                 817 
                 NH(CO)OCH 3   
                 n-propyl 
               
               
                 818 
                 NH(CO)OCH 3   
                 n-butyl 
               
               
                 819 
                 NH(CO)OCH 3   
                 n-pentyl 
               
               
                 820 
                 NH(CO)OCH 3   
                 n-hexanyl 
               
               
                 821 
                 NH(CO)OCH 3   
                 n-heptanyl 
               
               
                 822 
                 NH(CO)OCH 3   
                 isopropyl 
               
               
                 823 
                 NH(CO)OCH 3   
                 tert-butyl 
               
               
                 824 
                 NH(CO)OCH 3   
                 cyclopropyl 
               
               
                 825 
                 NH(CO)OCH 3   
                 cyclobutanyl 
               
               
                 826 
                 NH(CO)OCH 3   
                 cyclpentanyl 
               
               
                 827 
                 NH(CO)OCH 3   
                 cyclohexanyl 
               
               
                 828 
                 NH(CO)OCH 3   
                 cycloheptanyl 
               
               
                 829 
                 NH(CO)OCH 3   
                 phenyl 
               
               
                 830 
                 NH(CO)OCH 3   
                 phenylmethyl 
               
               
                 831 
                 NH(CO)OCH 3   
                 3-hydroxyphenyl 
               
               
                 832 
                 NH(CO)OCH 3   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 833 
                 NH(CO)OCH 3   
                 3-fluorophenyl 
               
               
                 834 
                 NH(CO)OCH 3   
                 3-chlorophenyl 
               
               
                 835 
                 NH(CO)OCH 3   
                 3-nitrophenyl 
               
               
                 836 
                 NH(CO)OCH 3   
                 3-aminophenyl 
               
               
                 837 
                 NH(CO)OCH 3   
                 3-methyl-sulfonamidephenyl 
               
               
                 838 
                 NH(CO)OCH 3   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 839 
                 NH(CO)OCH 3   
                 3-Ac—NHphenyl 
               
               
                 840 
                 NH(CO)OCH 3   
                 3-Boc—NHphenyl 
               
               
                 841 
                 NH(CO)OCH 3   
                 3-Cbz—NHphenyl 
               
               
                 842 
                 NH(CO)OCH 3   
                 3-aminomethylenephenyl 
               
               
                 843 
                 NH(CO)OCH 3   
                 3-aminoethylenephenyl 
               
               
                 844 
                 NH(CO)OCH 3   
                 3-cyanophenyl 
               
               
                 845 
                 NH(CO)OCH 3   
                 3-cyanomethylphenyl 
               
               
                 846 
                 NH(CO)OCH 3   
                 3-hydroxymethylenephenyl 
               
               
                 847 
                 NH(CO)OCH 3   
                 3-carboxylphenyl 
               
               
                 848 
                 NH(CO)OCH 3   
                 3-mercaptophenyl 
               
               
                 849 
                 NH(CO)OCH 3   
                 3-methoxyphenyl 
               
               
                 850 
                 NH(CO)OCH 3   
                 3,4-methylenedioxophenyl 
               
               
                 851 
                 NH(CO)OCH 3   
                 3-tetrazolephenyl 
               
               
                 852 
                 NH(CO)OCH 3   
                 3-aminosulfonylphenyl 
               
               
                 853 
                 NH(CO)OCH 3   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 854 
                 NH(CO)OCH 3   
                 3-ethylamino-sulfonylphenyl 
               
               
                 855 
                 NH(CO)OCH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 856 
                 NH(CO)OCH 3   
                 3-methylsulfonylphenyl 
               
               
                 857 
                 NH(CO)OCH 3   
                 4-methoxyphenyl 
               
               
                 858 
                 NH(CO)OCH 3   
                 4-phenylphenyl 
               
               
                 859 
                 NH(CO)OCH 3   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 860 
                 NH(CO)OCH 3   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 861 
                 NH(CO)OCH 3   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 862 
                 NH(CO)OCH 3   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 863 
                 NH(CO)OCH 3   
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 864 
                 NH(CO)OCH 3   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 865 
                 NH(CO)OCH 3   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 866 
                 NH(CO)OCH 3   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 867 
                 NH(CO)OCH 3   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 868 
                 NH(CO)OCH 3   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 869 
                 NH(CO)OCH 3   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 870 
                 NH(CO)OCH 3   
                 4-(2-methylphenyl)-phenyl 
               
               
                 871 
                 NH(CO)OCH 3   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 872 
                 NH(CO)OCH 3   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 873 
                 NH(CO)OCH 3   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 874 
                 NH(CO)OCH 3   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 875 
                 NH(CO)OCH 3   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 876 
                 NH(CO)OCH 3   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 877 
                 NH(CO)OCH 3   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 878 
                 NH(CO)OCH 3   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 879 
                 NH(CO)OCH 3   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 880 
                 NH(CO)OCH 3   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 881 
                 NH(CO)OCH 3   
                 4-(3-methylphenyl)-phenyl 
               
               
                 882 
                 NH(CO)OCH 3   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 883 
                 NH(CO)OCH 3   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 884 
                 NH(CO)OCH 3   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 885 
                 NH(CO)OCH 3   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 886 
                 NH(CO)OCH 3   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 887 
                 NH(CO)OCH 3   
                 2-pyridyl 
               
               
                 888 
                 NH(CO)OCH 3   
                 3-pyridyl 
               
               
                 889 
                 NH(CO)OCH 3   
                 4-pyridyl 
               
               
                 890 
                 NH(CO)OCH 3   
                 3-amino-4-pyridyl 
               
               
                 891 
                 NH(CO)OCH 3   
                 3-hydroxy-4-pyridyl 
               
               
                 892 
                 NH(CO)OCH 3   
                 3-imidazole 
               
               
                 893 
                 NH(CO)OCH 3   
                 2-nitro-3-imidazole 
               
               
                 894 
                 NH(CO)OCH 3   
                 5-thiazole 
               
               
                 895 
                 NH(CO)OCH 3   
                 5-oxazole 
               
               
                 896 
                 NH(CO)OCH 3   
                 4-pyazole 
               
               
                 897 
                 NH(CO)OCH 3   
                 phenylethyl 
               
               
                 898 
                 NH(CO)OCH 3   
                 2-aminophenylethyl 
               
               
                 899 
                 NH(CO)OCH 3   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 900 
                 NH(CO)OCH 3   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 aminophenylethyl 
               
               
                 901 
                 NH(CO)OCH 3   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 902 
                 NH(CO)OCH 3   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 903 
                 NH(CO)OCH 3   
                 2-tetrazolephenylethyl 
               
               
                 904 
                 NH(CO)OCH 3   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 905 
                 NH(CO)OCH 3   
                 2-aminosulfonyl-phenylethyl 
               
               
                 906 
                 NH(CO)OCH 3   
                 2-methoxyphenylethyl 
               
               
                 907 
                 NH(CO)OCH 3   
                 3-aminophenylethyl 
               
               
                 908 
                 NH(CO)OCH 3   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 909 
                 NH(CO)OCH 3   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 910 
                 NH(CO)OCH 3   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 911 
                 NH(CO)OCH 3   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 912 
                 NH(CO)OCH 3   
                 3-tetrazolephenylethyl 
               
               
                 913 
                 NH(CO)OCH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 914 
                 NH(CO)OCH 3   
                 3-aminosulfonyl-phenylethyl 
               
               
                 915 
                 NH(CO)OCH 3   
                 3-methoxyphenylethyl 
               
               
                 916 
                 NHBoc 
                 H 
               
               
                 917 
                 NHBoc 
                 methyl 
               
               
                 918 
                 NHBoc 
                 ethyl 
               
               
                 919 
                 NHBoc 
                 n-propyl 
               
               
                 920 
                 NHBoc 
                 n-butyl 
               
               
                 921 
                 NHBoc 
                 n-pentyl 
               
               
                 922 
                 NHBoc 
                 n-hexanyl 
               
               
                 923 
                 NHBoc 
                 n-heptanyl 
               
               
                 924 
                 NHBoc 
                 isopropyl 
               
               
                 925 
                 NHBoc 
                 tert-butyl 
               
               
                 926 
                 NHBoc 
                 cyclopropyl 
               
               
                 927 
                 NHBoc 
                 cyclobutanyl 
               
               
                 928 
                 NHBoc 
                 cyclpentanyl 
               
               
                 929 
                 NHBoc 
                 cyclohexanyl 
               
               
                 930 
                 NHBoc 
                 cycloheptanyl 
               
               
                 931 
                 NHBoc 
                 phenyl 
               
               
                 932 
                 NHBoc 
                 phenylmethyl 
               
               
                 933 
                 NHBoc 
                 3-hydroxyphenyl 
               
               
                 934 
                 NHBoc 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 935 
                 NHBoc 
                 3-fluorophenyl 
               
               
                 936 
                 NHBoc 
                 3-chlorophenyl 
               
               
                 937 
                 NHBoc 
                 3-nitrophenyl 
               
               
                 938 
                 NHBoc 
                 3-aminophenyl 
               
               
                 939 
                 NHBoc 
                 3-methyl-sulfonamidephenyl 
               
               
                 940 
                 NHBoc 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 941 
                 NHBoc 
                 3-Ac—NHphenyl 
               
               
                 942 
                 NHBoc 
                 3-Boc—NHphenyl 
               
               
                 943 
                 NHBoc 
                 3-Cbz—NHphenyl 
               
               
                 944 
                 NHBoc 
                 3-aminomethylenephenyl 
               
               
                 945 
                 NHBoc 
                 3-aminoethylenephenyl 
               
               
                 946 
                 NHBoc 
                 3-cyanophenyl 
               
               
                 947 
                 NHBoc 
                 3-cyanomethylphenyl 
               
               
                 948 
                 NHBoc 
                 3-hydroxymethylenephenyl 
               
               
                 949 
                 NHBoc 
                 3-carboxylphenyl 
               
               
                 950 
                 NHBoc 
                 3-mercaptophenyl 
               
               
                 951 
                 NHBoc 
                 3-methoxyphenyl 
               
               
                 952 
                 NHBoc 
                 3,4-methylenedioxophenyl 
               
               
                 953 
                 NHBoc 
                 3-tetrazolephenyl 
               
               
                 954 
                 NHBoc 
                 3-aminosulfonylphenyl 
               
               
                 955 
                 NHBoc 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 956 
                 NHBoc 
                 3-ethylamino-sulfonylphenyl 
               
               
                 957 
                 NHBoc 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 958 
                 NHBoc 
                 3-methylsulfonylphenyl 
               
               
                 959 
                 NHBoc 
                 4-methoxyphenyl 
               
               
                 960 
                 NHBoc 
                 4-phenylphenyl 
               
               
                 961 
                 NHBoc 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 962 
                 NHBoc 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 963 
                 NHBoc 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 964 
                 NHBoc 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 965 
                 NHBoc 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 966 
                 NHBoc 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 967 
                 NHBoc 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 968 
                 NHBoc 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 969 
                 NHBoc 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 970 
                 NHBoc 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 971 
                 NHBoc 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 972 
                 NHBoc 
                 4-(2-methylphenyl)-phenyl 
               
               
                 973 
                 NHBoc 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 974 
                 NHBoc 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 975 
                 NHBoc 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 976 
                 NHBoc 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 977 
                 NHBoc 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 978 
                 NHBoc 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 979 
                 NHBoc 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 980 
                 NHBoc 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 981 
                 NHBoc 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 982 
                 NHBoc 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 983 
                 NHBoc 
                 4-(3-methylphenyl)-phenyl 
               
               
                 984 
                 NHBoc 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 985 
                 NHBoc 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 986 
                 NHBoc 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 987 
                 NHBoc 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 988 
                 NHBoc 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 989 
                 NHBoc 
                 2-pyridyl 
               
               
                 990 
                 NHBoc 
                 3-pyridyl 
               
               
                 991 
                 NHBoc 
                 4-pyridyl 
               
               
                 992 
                 NHBoc 
                 3-amino-4-pyridyl 
               
               
                 993 
                 NHBoc 
                 3-hydroxy-4-pyridyl 
               
               
                 994 
                 NHBoc 
                 3-imidazole 
               
               
                 995 
                 NHBoc 
                 2-nitro-3-imidazole 
               
               
                 996 
                 NHBoc 
                 5-thiazole 
               
               
                 997 
                 NHBoc 
                 5-oxazole 
               
               
                 998 
                 NHBoc 
                 4-pyazole 
               
               
                 999 
                 NHBoc 
                 phenylethyl 
               
               
                 1000 
                 NHBoc 
                 2-aminophenylethyl 
               
               
                 1001 
                 NHBoc 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1002 
                 NHBoc 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1003 
                 NHBoc 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1004 
                 NHBoc 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1005 
                 NHBoc 
                 2-tetrazolephenylethyl 
               
               
                 1006 
                 NHBoc 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1007 
                 NHBoc 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1008 
                 NHBoc 
                 2-methoxyphenylethyl 
               
               
                 1009 
                 NHBoc 
                 3-aminophenylethyl 
               
               
                 1010 
                 NHBoc 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1011 
                 NHBoc 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1012 
                 NHBoc 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1013 
                 NHBoc 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1014 
                 NHBoc 
                 3-tetrazolephenylethyl 
               
               
                 1015 
                 NHBoc 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1016 
                 NHBoc 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1017 
                 NHBoc 
                 3-methoxyphenylethyl 
               
               
                 1018 
                 NH(CO)OCH 2 -4-pyridyl 
                 H 
               
               
                 1019 
                 NH(CO)OCH 2 -4-pyridyl 
                 methyl 
               
               
                 1020 
                 NH(CO)OCH 2 -4-pyridyl 
                 ethyl 
               
               
                 1021 
                 NH(CO)OCH 2 -4-pyridyl 
                 n-propyl 
               
               
                 1022 
                 NH(CO)OCH 2 -4-pyridyl 
                 n-butyl 
               
               
                 1023 
                 NH(CO)OCH 2 -4-pyridyl 
                 n-pentyl 
               
               
                 1024 
                 NH(CO)OCH 2 -4-pyridyl 
                 n-hexanyl 
               
               
                 1025 
                 NH(CO)OCH 2 -4-pyridyl 
                 n-heptanyl 
               
               
                 1026 
                 NH(CO)OCH 2 -4-pyridyl 
                 isopropyl 
               
               
                 1027 
                 NH(CO)OCH 2 -4-pyridyl 
                 tert-butyl 
               
               
                 1028 
                 NH(CO)OCH 2 -4-pyridyl 
                 cyclopropyl 
               
               
                 1029 
                 NH(CO)OCH 2 -4-pyridyl 
                 cyclobutanyl 
               
               
                 1030 
                 NH(CO)OCH 2 -4-pyridyl 
                 cyclpentanyl 
               
               
                 1031 
                 NH(CO)OCH 2 -4-pyridyl 
                 cyclohexanyl 
               
               
                 1032 
                 NH(CO)OCH 2 -4-pyridyl 
                 cycloheptanyl 
               
               
                 1033 
                 NH(CO)OCH 2 -4-pyridyl 
                 phenyl 
               
               
                 1034 
                 NH(CO)OCH 2 -4-pyridyl 
                 phenylmethyl 
               
               
                 1035 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-hydroxyphenyl 
               
               
                 1036 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1037 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-fluorophenyl 
               
               
                 1038 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-chlorophenyl 
               
               
                 1039 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-nitrophenyl 
               
               
                 1040 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminophenyl 
               
               
                 1041 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methyl-sulfonamidephenyl 
               
               
                 1042 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1043 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-Ac—NHphenyl 
               
               
                 1044 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-Boc—NHphenyl 
               
               
                 1045 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-Cbz—NHphenyl 
               
               
                 1046 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminomethylenephenyl 
               
               
                 1047 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminoethylenephenyl 
               
               
                 1048 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-cyanophenyl 
               
               
                 1049 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-cyanomethylphenyl 
               
               
                 1050 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-hydroxymethylenephenyl 
               
               
                 1051 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-carboxylphenyl 
               
               
                 1052 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-mercaptophenyl 
               
               
                 1053 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methoxyphenyl 
               
               
                 1054 
                 NH(CO)OCH 2 -4-pyridyl 
                 3,4-methylenedioxophenyl 
               
               
                 1055 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-tetrazolephenyl 
               
               
                 1056 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminosulfonylphenyl 
               
               
                 1057 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1058 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1059 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1060 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methylsulfonylphenyl 
               
               
                 1061 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-methoxyphenyl 
               
               
                 1062 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-phenylphenyl 
               
               
                 1063 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1064 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1065 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1066 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1067 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1068 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1069 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1070 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1071 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1072 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1073 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1074 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1075 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1076 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1077 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1078 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1079 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1080 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1081 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1082 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1083 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1084 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1085 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1086 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1087 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1088 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1089 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1090 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1091 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-pyridyl 
               
               
                 1092 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-pyridyl 
               
               
                 1093 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-pyridyl 
               
               
                 1094 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-amino-4-pyridyl 
               
               
                 1095 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-hydroxy-4-pyridyl 
               
               
                 1096 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-imidazole 
               
               
                 1097 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-nitro-3-imidazole 
               
               
                 1098 
                 NH(CO)OCH 2 -4-pyridyl 
                 5-thiazole 
               
               
                 1099 
                 NH(CO)OCH 2 -4-pyridyl 
                 5-oxazole 
               
               
                 1100 
                 NH(CO)OCH 2 -4-pyridyl 
                 4-pyazole 
               
               
                 1101 
                 NH(CO)OCH 2 -4-pyridyl 
                 phenylethyl 
               
               
                 1102 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-aminophenylethyl 
               
               
                 1103 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1104 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1105 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1106 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1107 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-tetrazolephenylethyl 
               
               
                 1108 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1109 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1110 
                 NH(CO)OCH 2 -4-pyridyl 
                 2-methoxyphenylethyl 
               
               
                 1111 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminophenylethyl 
               
               
                 1112 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1113 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1114 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1115 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1116 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-tetrazolephenylethyl 
               
               
                 1117 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1118 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1119 
                 NH(CO)OCH 2 -4-pyridyl 
                 3-methoxyphenylethyl 
               
               
                 1120 
                 NHS(O 2 )CH 3   
                 H 
               
               
                 1121 
                 NHS(O 2 )CH 3   
                 methyl 
               
               
                 1122 
                 NHS(O 2 )CH 3   
                 ethyl 
               
               
                 1123 
                 NHS(O 2 )CH 3   
                 n-propyl 
               
               
                 1124 
                 NHS(O 2 )CH 3   
                 n-butyl 
               
               
                 1125 
                 NHS(O 2 )CH 3   
                 n-pentyl 
               
               
                 1126 
                 NHS(O 2 )CH 3   
                 n-hexanyl 
               
               
                 1127 
                 NHS(O 2 )CH 3   
                 n-heptanyl 
               
               
                 1128 
                 NHS(O 2 )CH 3   
                 isopropyl 
               
               
                 1129 
                 NHS(O 2 )CH 3   
                 tert-butyl 
               
               
                 1130 
                 NHS(O 2 )CH 3   
                 cyclopropyl 
               
               
                 1131 
                 NHS(O 2 )CH 3   
                 cyclobutanyl 
               
               
                 1132 
                 NHS(O 2 )CH 3   
                 cyclpentanyl 
               
               
                 1133 
                 NHS(O 2 )CH 3   
                 cyclohexanyl 
               
               
                 1134 
                 NHS(O 2 )CH 3   
                 cycloheptanyl 
               
               
                 1135 
                 NHS(O 2 )CH 3   
                 phenyl 
               
               
                 1136 
                 NHS(O 2 )CH 3   
                 phenylmethyl 
               
               
                 1137 
                 NHS(O 2 )CH 3   
                 3-hydroxyphenyl 
               
               
                 1138 
                 NHS(O 2 )CH 3   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1139 
                 NHS(O 2 )CH 3   
                 3-fluorophenyl 
               
               
                 1140 
                 NHS(O 2 )CH 3   
                 3-chlorophenyl 
               
               
                 1141 
                 NHS(O 2 )CH 3   
                 3-nitrophenyl 
               
               
                 1142 
                 NHS(O 2 )CH 3   
                 3-aminophenyl 
               
               
                 1143 
                 NHS(O 2 )CH 3   
                 3-methyl-sulfonamidephenyl 
               
               
                 1144 
                 NHS(O 2 )CH 3   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1145 
                 NHS(O 2 )CH 3   
                 3-Ac—NHphenyl 
               
               
                 1146 
                 NHS(O 2 )CH 3   
                 3-Boc—NHphenyl 
               
               
                 1147 
                 NHS(O 2 )CH 3   
                 3-Cbz—NHphenyl 
               
               
                 1148 
                 NHS(O 2 )CH 3   
                 3-aminomethylenephenyl 
               
               
                 1149 
                 NHS(O 2 )CH 3   
                 3-aminoethylenephenyl 
               
               
                 1150 
                 NHS(O 2 )CH 3   
                 3-cyanophenyl 
               
               
                 1151 
                 NHS(O 2 )CH 3   
                 3-cyanomethylphenyl 
               
               
                 1152 
                 NHS(O 2 )CH 3   
                 3-hydroxymethylenephenyl 
               
               
                 1153 
                 NHS(O 2 )CH 3   
                 3-carboxylphenyl 
               
               
                 1154 
                 NHS(O 2 )CH 3   
                 3-mercaptophenyl 
               
               
                 1155 
                 NHS(O 2 )CH 3   
                 3-methoxyphenyl 
               
               
                 1156 
                 NHS(O 2 )CH 3   
                 3,4-methylenedioxophenyl 
               
               
                 1157 
                 NHS(O 2 )CH 3   
                 3-tetrazolephenyl 
               
               
                 1158 
                 NHS(O 2 )CH 3   
                 3-aminosulfonylphenyl 
               
               
                 1159 
                 NHS(O 2 )CH 3   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1160 
                 NHS(O 2 )CH 3   
                 3-ethylamino-sulfonylphenyl 
               
               
                 1161 
                 NHS(O 2 )CH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1162 
                 NHS(O 2 )CH 3   
                 3-methylsulfonylphenyl 
               
               
                 1163 
                 NHS(O 2 )CH 3   
                 4-methoxyphenyl 
               
               
                 1164 
                 NHS(O 2 )CH 3   
                 4-phenylphenyl 
               
               
                 1165 
                 NHS(O 2 )CH 3   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1166 
                 NHS(O 2 )CH 3   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1167 
                 NHS(O 2 )CH 3   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1168 
                 NHS(O 2 )CH 3   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1169 
                 NHS(O 2 )CH 3   
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1170 
                 NHS(O 2 )CH 3   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1171 
                 NHS(O 2 )CH 3   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1172 
                 NHS(O 2 )CH 3   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1173 
                 NHS(O 2 )CH 3   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1174 
                 NHS(O 2 )CH 3   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1175 
                 NHS(O 2 )CH 3   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1176 
                 NHS(O 2 )CH 3   
                 4-(2-methylphenyl)-phenyl 
               
               
                 1177 
                 NHS(O 2 )CH 3   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1178 
                 NHS(O 2 )CH 3   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1179 
                 NHS(O 2 )CH 3   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1180 
                 NHS(O 2 )CH 3   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1181 
                 NHS(O 2 )CH 3   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1182 
                 NHS(O 2 )CH 3   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1183 
                 NHS(O 2 )CH 3   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1184 
                 NHS(O 2 )CH 3   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1185 
                 NHS(O 2 )CH 3   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1186 
                 NHS(O 2 )CH 3   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1187 
                 NHS(O 2 )CH 3   
                 4-(3-methylphenyl)-phenyl 
               
               
                 1188 
                 NHS(O 2 )CH 3   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1189 
                 NHS(O 2 )CH 3   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1190 
                 NHS(O 2 )CH 3   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1191 
                 NHS(O 2 )CH 3   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1192 
                 NHS(O 2 )CH 3   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1193 
                 NHS(O 2 )CH 3   
                 2-pyridyl 
               
               
                 1194 
                 NHS(O 2 )CH 3   
                 3-pyridyl 
               
               
                 1195 
                 NHS(O 2 )CH 3   
                 4-pyridyl 
               
               
                 1196 
                 NHS(O 2 )CH 3   
                 3-amino-4-pyridyl 
               
               
                 1197 
                 NHS(O 2 )CH 3   
                 3-hydroxy-4-pyridyl 
               
               
                 1198 
                 NHS(O 2 )CH 3   
                 3-imidazole 
               
               
                 1199 
                 NHS(O 2 )CH 3   
                 2-nitro-3-imidazole 
               
               
                 1200 
                 NHS(O 2 )CH 3   
                 5-thiazole 
               
               
                 1201 
                 NHS(O 2 )CH 3   
                 5-oxazole 
               
               
                 1202 
                 NHS(O 2 )CH 3   
                 4-pyazole 
               
               
                 1203 
                 NHS(O 2 )CH 3   
                 phenylethyl 
               
               
                 1204 
                 NHS(O 2 )CH 3   
                 2-aminophenylethyl 
               
               
                 1205 
                 NHS(O 2 )CH 3   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1206 
                 NHS(O 2 )CH 3   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1207 
                 NHS(O 2 )CH 3   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1208 
                 NHS(O 2 )CH 3   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1209 
                 NHS(O 2 )CH 3   
                 2-tetrazolephenylethyl 
               
               
                 1210 
                 NHS(O 2 )CH 3   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1211 
                 NHS(O 2 )CH 3   
                 2-aminosulfonyl-phenylethyl 
               
               
                 1212 
                 NHS(O 2 )CH 3   
                 2-methoxyphenylethyl 
               
               
                 1213 
                 NHS(O 2 )CH 3   
                 3-aminophenylethyl 
               
               
                 1214 
                 NHS(O 2 )CH 3   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1215 
                 NHS(O 2 )CH 3   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1216 
                 NHS(O 2 )CH 3   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1217 
                 NHS(O 2 )CH 3   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1218 
                 NHS(O 2 )CH 3   
                 3-tetrazolephenylethyl 
               
               
                 1219 
                 NHS(O 2 )CH 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1220 
                 NHS(O 2 )CH 3   
                 3-aminosulfonyl-phenylethyl 
               
               
                 1221 
                 NHS(O 2 )CH 3   
                 3-methoxyphenylethyl 
               
               
                 1222 
                 NHS(O 2 )CF 3   
                 H 
               
               
                 1223 
                 NHS(O 2 )CF 3   
                 methyl 
               
               
                 1224 
                 NHS(O 2 )CF 3   
                 ethyl 
               
               
                 1225 
                 NHS(O 2 )CF 3   
                 n-propyl 
               
               
                 1226 
                 NHS(O 2 )CF 3   
                 n-butyl 
               
               
                 1227 
                 NHS(O 2 )CF 3   
                 n-pentyl 
               
               
                 1228 
                 NHS(O 2 )CF 3   
                 n-hexanyl 
               
               
                 1229 
                 NHS(O 2 )CF 3   
                 n-heptanyl 
               
               
                 1230 
                 NHS(O 2 )CF 3   
                 isopropyl 
               
               
                 1231 
                 NHS(O 2 )CF 3   
                 tert-butyl 
               
               
                 1232 
                 NHS(O 2 )CF 3   
                 cyclopropyl 
               
               
                 1233 
                 NHS(O 2 )CF 3   
                 cyclobutanyl 
               
               
                 1234 
                 NHS(O 2 )CF 3   
                 cyclpentanyl 
               
               
                 1235 
                 NHS(O 2 )CF 3   
                 cyclohexanyl 
               
               
                 1236 
                 NHS(O 2 )CF 3   
                 cycloheptanyl 
               
               
                 1237 
                 NHS(O 2 )CF 3   
                 phenyl 
               
               
                 1238 
                 NHS(O 2 )CF 3   
                 phenylmethyl 
               
               
                 1239 
                 NHS(O 2 )CF 3   
                 3-hydroxyphenyl 
               
               
                 1240 
                 NHS(O 2 )CF 3   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1241 
                 NHS(O 2 )CF 3   
                 3-fluorophenyl 
               
               
                 1242 
                 NHS(O 2 )CF 3   
                 3-chlorophenyl 
               
               
                 1243 
                 NHS(O 2 )CF 3   
                 3-nitrophenyl 
               
               
                 1244 
                 NHS(O 2 )CF 3   
                 3-aminophenyl 
               
               
                 1245 
                 NHS(O 2 )CF 3   
                 3-methyl-sulfonamidephenyl 
               
               
                 1246 
                 NHS(O 2 )CF 3   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1247 
                 NHS(O 2 )CF 3   
                 3-Ac—NHphenyl 
               
               
                 1248 
                 NHS(O 2 )CF 3   
                 3-Boc—NHphenyl 
               
               
                 1249 
                 NHS(O 2 )CF 3   
                 3-Cbz—NHphenyl 
               
               
                 1250 
                 NHS(O 2 )CF 3   
                 3-aminomethylenephenyl 
               
               
                 1251 
                 NHS(O 2 )CF 3   
                 3-aminoethylenephenyl 
               
               
                 1252 
                 NHS(O 2 )CF 3   
                 3-cyanophenyl 
               
               
                 1253 
                 NHS(O 2 )CF 3   
                 3-cyanomethylphenyl 
               
               
                 1254 
                 NHS(O 2 )CF 3   
                 3-hydroxymethylenephenyl 
               
               
                 1255 
                 NHS(O 2 )CF 3   
                 3-carboxylphenyl 
               
               
                 1256 
                 NHS(O 2 )CF 3   
                 3-mercaptophenyl 
               
               
                 1257 
                 NHS(O 2 )CF 3   
                 3-methoxyphenyl 
               
               
                 1258 
                 NHS(O 2 )CF 3   
                 3,4-methylenedioxophenyl 
               
               
                 1259 
                 NHS(O 2 )CF 3   
                 3-tetrazolephenyl 
               
               
                 1260 
                 NHS(O 2 )CF 3   
                 3-aminosulfonylphenyl 
               
               
                 1261 
                 NHS(O 2 )CF 3   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1262 
                 NHS(O 2 )CF 3   
                 3-ethylamino-sulfonylphenyl 
               
               
                 1263 
                 NHS(O 2 )CF 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1264 
                 NHS(O 2 )CF 3   
                 3-methylsulfonylphenyl 
               
               
                 1265 
                 NHS(O 2 )CF 3   
                 4-methoxyphenyl 
               
               
                 1266 
                 NHS(O 2 )CF 3   
                 4-phenylphenyl 
               
               
                 1267 
                 NHS(O 2 )CF 3   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1268 
                 NHS(O 2 )CF 3   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1269 
                 NHS(O 2 )CF 3   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1270 
                 NHS(O 2 )CF 3   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1271 
                 NHS(O 2 )CF 3   
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1272 
                 NHS(O 2 )CF 3   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1273 
                 NHS(O 2 )CF 3   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1274 
                 NHS(O 2 )CF 3   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1275 
                 NHS(O 2 )CF 3   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1276 
                 NHS(O 2 )CF 3   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1277 
                 NHS(O 2 )CF 3   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1278 
                 NHS(O 2 )CF 3   
                 4-(2-methylphenyl)-phenyl 
               
               
                 1279 
                 NHS(O 2 )CF 3   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1280 
                 NHS(O 2 )CF 3   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1281 
                 NHS(O 2 )CF 3   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1282 
                 NHS(O 2 )CF 3   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1283 
                 NHS(O 2 )CF 3   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1284 
                 NHS(O 2 )CF 3   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1285 
                 NHS(O 2 )CF 3   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1286 
                 NHS(O 2 )CF 3   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1287 
                 NHS(O 2 )CF 3   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1288 
                 NHS(O 2 )CF 3   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1289 
                 NHS(O 2 )CF 3   
                 4-(3-methylphenyl)-phenyl 
               
               
                 1290 
                 NHS(O 2 )CF 3   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1291 
                 NHS(O 2 )CF 3   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1292 
                 NHS(O 2 )CF 3   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1293 
                 NHS(O 2 )CF 3   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1294 
                 NHS(O 2 )CF 3   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1295 
                 NHS(O 2 )CF 3   
                 2-pyridyl 
               
               
                 1296 
                 NHS(O 2 )CF 3   
                 3-pyridyl 
               
               
                 1297 
                 NHS(O 2 )CF 3   
                 4-pyridyl 
               
               
                 1298 
                 NHS(O 2 )CF 3   
                 3-amino-4-pyridyl 
               
               
                 1299 
                 NHS(O 2 )CF 3   
                 3-hydroxy-4-pyridyl 
               
               
                 1300 
                 NHS(O 2 )CF 3   
                 3-imidazole 
               
               
                 1301 
                 NHS(O 2 )CF 3   
                 2-nitro-3-imidazole 
               
               
                 1302 
                 NHS(O 2 )CF 3   
                 5-thiazole 
               
               
                 1303 
                 NHS(O 2 )CF 3   
                 5-oxazole 
               
               
                 1304 
                 NHS(O 2 )CF 3   
                 4-pyazole 
               
               
                 1305 
                 NHS(O 2 )CF 3   
                 phenylethyl 
               
               
                 1306 
                 NHS(O 2 )CF 3   
                 2-aminophenylethyl 
               
               
                 1307 
                 NHS(O 2 )CF 3   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1308 
                 NHS(O 2 )CF 3   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1309 
                 NHS(O 2 )CF 3   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1310 
                 NHS(O 2 )CF 3   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1311 
                 NHS(O 2 )CF 3   
                 2-tetrazolephenylethyl 
               
               
                 1312 
                 NHS(O 2 )CF 3   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1313 
                 NHS(O 2 )CF 3   
                 2-aminosulfonyl-phenylethyl 
               
               
                 1314 
                 NHS(O 2 )CF 3   
                 2-methoxyphenylethyl 
               
               
                 1315 
                 NHS(O 2 )CF 3   
                 3-aminophenylethyl 
               
               
                 1316 
                 NHS(O 2 )CF 3   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1317 
                 NHS(O 2 )CF 3   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1318 
                 NHS(O 2 )CF 3   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1319 
                 NHS(O 2 )CF 3   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1320 
                 NHS(O 2 )CF 3   
                 3-tetrazolephenylethyl 
               
               
                 1321 
                 NHS(O 2 )CF 3   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1322 
                 NHS(O 2 )CF 3   
                 3-aminosulfonyl-phenylethyl 
               
               
                 1323 
                 NHS(O 2 )CF 3   
                 3-methoxyphenylethyl 
               
               
                 1324 
                 4-aminophenylS(O)2NH 
                 H 
               
               
                 1325 
                 4-aminophenylS(O)2NH 
                 methyl 
               
               
                 1326 
                 4-aminophenylS(O)2NH 
                 ethyl 
               
               
                 1327 
                 4-aminophenylS(O)2NH 
                 n-propyl 
               
               
                 1328 
                 4-aminophenylS(O)2NH 
                 n-butyl 
               
               
                 1329 
                 4-aminophenylS(O)2NH 
                 n-pentyl 
               
               
                 1330 
                 4-aminophenylS(O)2NH 
                 n-hexanyl 
               
               
                 1331 
                 4-aminophenylS(O)2NH 
                 n-heptanyl 
               
               
                 1332 
                 4-aminophenylS(O)2NH 
                 isopropyl 
               
               
                 1333 
                 4-aminophenylS(O)2NH 
                 tert-butyl 
               
               
                 1334 
                 4-aminophenylS(O)2NH 
                 cyclopropyl 
               
               
                 1335 
                 4-aminophenylS(O)2NH 
                 cyclobutanyl 
               
               
                 1336 
                 4-aminophenylS(O)2NH 
                 cyclpentanyl 
               
               
                 1337 
                 4-aminophenylS(O)2NH 
                 cyclohexanyl 
               
               
                 1338 
                 4-aminophenylS(O)2NH 
                 cycloheptanyl 
               
               
                 1339 
                 4-aminophenylS(O)2NH 
                 phenyl 
               
               
                 1340 
                 4-aminophenylS(O)2NH 
                 phenylmethyl 
               
               
                 1341 
                 4-aminophenylS(O)2NH 
                 3-hydroxyphenyl 
               
               
                 1342 
                 4-aminophenylS(O)2NH 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1343 
                 4-aminophenylS(O)2NH 
                 3-fluorophenyl 
               
               
                 1344 
                 4-aminophenylS(O)2NH 
                 3-chlorophenyl 
               
               
                 1345 
                 4-aminophenylS(O)2NH 
                 3-nitrophenyl 
               
               
                 1346 
                 4-aminophenylS(O)2NH 
                 3-aminophenyl 
               
               
                 1347 
                 4-aminophenylS(O)2NH 
                 3-methyl-sulfonamidephenyl 
               
               
                 1348 
                 4-aminophenylS(O)2NH 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1349 
                 4-aminophenylS(O)2NH 
                 3-Ac—NHphenyl 
               
               
                 1350 
                 4-aminophenylS(O)2NH 
                 3-Boc—NHphenyl 
               
               
                 1351 
                 4-aminophenylS(O)2NH 
                 3-Cbz—NHphenyl 
               
               
                 1352 
                 4-aminophenylS(O)2NH 
                 3-aminomethylenephenyl 
               
               
                 1353 
                 4-aminophenylS(O)2NH 
                 3-aminoethylenephenyl 
               
               
                 1354 
                 4-aminophenylS(O)2NH 
                 3-cyanophenyl 
               
               
                 1355 
                 4-aminophenylS(O)2NH 
                 3-cyanomethylphenyl 
               
               
                 1356 
                 4-aminophenylS(O)2NH 
                 3-hydroxymethylenephenyl 
               
               
                 1357 
                 4-aminophenylS(O)2NH 
                 3-carboxylphenyl 
               
               
                 1358 
                 4-aminophenylS(O)2NH 
                 3-mercaptophenyl 
               
               
                 1359 
                 4-aminophenylS(O)2NH 
                 3-methoxyphenyl 
               
               
                 1360 
                 4-aminophenylS(O)2NH 
                 3,4-methylenedioxophenyl 
               
               
                 1361 
                 4-aminophenylS(O)2NH 
                 3-tetrazolephenyl 
               
               
                 1362 
                 4-aminophenylS(O)2NH 
                 3-aminosulfonylphenyl 
               
               
                 1363 
                 4-aminophenylS(O)2NH 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1364 
                 4-aminophenylS(O)2NH 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1365 
                 4-aminophenylS(O)2NH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1366 
                 4-aminophenylS(O)2NH 
                 3-methylsulfonylphenyl 
               
               
                 1367 
                 4-aminophenylS(O)2NH 
                 4-methoxyphenyl 
               
               
                 1368 
                 4-aminophenylS(O)2NH 
                 4-phenylphenyl 
               
               
                 1369 
                 4-aminophenylS(O)2NH 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1370 
                 4-aminophenylS(O)2NH 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1371 
                 4-aminophenylS(O)2NH 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1372 
                 4-aminophenylS(O)2NH 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1373 
                 4-aminophenylS(O)2NH 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1374 
                 4-aminophenylS(O)2NH 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1375 
                 4-aminophenylS(O)2NH 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1376 
                 4-aminophenylS(O)2NH 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1377 
                 4-aminophenylS(O)2NH 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1378 
                 4-aminophenylS(O) 2 NH 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1379 
                 4-aminophenylS(O) 2 NH 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1380 
                 4-aminophenylS(O) 2 NH 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1381 
                 4-aminophenylS(O) 2 NH 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1382 
                 4-aminophenylS(O) 2 NH 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1383 
                 4-aminophenylS(O) 2 NH 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1384 
                 4-aminophenylS(O) 2 NH 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1385 
                 4-aminophenylS(O) 2 NH 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1386 
                 4-aminophenylS(O) 2 NH 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1387 
                 4-aminophenylS(O) 2 NH 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1388 
                 4-aminophenylS(O) 2 NH 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1389 
                 4-aminophenylS(O) 2 NH 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1390 
                 4-aminophenylS(O) 2 NH 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1391 
                 4-aminophenylS(O) 2 NH 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1392 
                 4-aminophenylS(O) 2 NH 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1393 
                 4-aminophenylS(O) 2 NH 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1394 
                 4-aminophenylS(O) 2 NH 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1395 
                 4-aminophenylS(O) 2 NH 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1396 
                 4-aminophenylS(O) 2 NH 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1397 
                 4-aminophenylS(O) 2 NH 
                 2-pyridyl 
               
               
                 1398 
                 4-aminophenylS(O) 2 NH 
                 3-pyridyl 
               
               
                 1399 
                 4-aminophenylS(O) 2 NH 
                 4-pyridyl 
               
               
                 1400 
                 4-aminophenylS(O) 2 NH 
                 3-amino-4-pyridyl 
               
               
                 1401 
                 4-aminophenylS(O) 2 NH 
                 3-hydroxy-4-pyridyl 
               
               
                 1402 
                 4-aminophenylS(O) 2 NH 
                 3-imidazole 
               
               
                 1403 
                 4-aminophenylS(O) 2 NH 
                 2-nitro-3-imidazole 
               
               
                 1404 
                 4-aminophenylS(O) 2 NH 
                 5-thiazole 
               
               
                 1405 
                 4-aminophenylS(O) 2 NH 
                 5-oxazole 
               
               
                 1406 
                 4-aminophenylS(O) 2 NH 
                 4-pyazole 
               
               
                 1407 
                 4-aminophenylS(O) 2 NH 
                 phenylethyl 
               
               
                 1408 
                 4-aminophenylS(O) 2 NH 
                 2-aminophenylethyl 
               
               
                 1409 
                 4-aminophenylS(O) 2 NH 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1410 
                 4-aminophenylS(O) 2 NH 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1411 
                 4-aminophenylS(O) 2 NH 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1412 
                 4-aminophenylS(O) 2 NH 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1413 
                 4-aminophenylS(O) 2 NH 
                 2-tetrazolephenylethyl 
               
               
                 1414 
                 4-aminophenylS(O) 2 NH 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1415 
                 4-aminophenylS(O) 2 NH 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1416 
                 4-aminophenylS(O) 2 NH 
                 2-methoxyphenylethyl 
               
               
                 1417 
                 4-aminophenylS(O) 2 NH 
                 3-aminophenylethyl 
               
               
                 1418 
                 4-aminophenylS(O) 2 NH 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1419 
                 4-aminophenylS(O) 2 NH 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1420 
                 4-aminophenylS(O) 2 NH 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1421 
                 4-aminophenylS(O) 2 NH 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1422 
                 4-aminophenylS(O) 2 NH 
                 3-tetrazolephenylethyl 
               
               
                 1423 
                 4-aminophenylS(O) 2 NH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1424 
                 4-aminophenylS(O) 2 NH 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1425 
                 4-aminophenylS(O) 2 NH 
                 3-methoxyphenylethyl 
               
               
                 1426 
                 NH(CO)NMe 2   
                 H 
               
               
                 1427 
                 NH(CO)NMe 2   
                 methyl 
               
               
                 1428 
                 NH(CO)NMe 2   
                 ethyl 
               
               
                 1429 
                 NH(CO)NMe 2   
                 n-propyl 
               
               
                 1430 
                 NH(CO)NMe 2   
                 n-butyl 
               
               
                 1431 
                 NH(CO)NMe 2   
                 n-pentyl 
               
               
                 1432 
                 NH(CO)NMe 2   
                 n-hexanyl 
               
               
                 1433 
                 NH(CO)NMe 2   
                 n-heptanyl 
               
               
                 1434 
                 NH(CO)NMe 2   
                 isopropyl 
               
               
                 1435 
                 NH(CO)NMe 2   
                 tert-butyl 
               
               
                 1436 
                 NH(CO)NMe 2   
                 cyclopropyl 
               
               
                 1437 
                 NH(CO)NMe 2   
                 cyclobutanyl 
               
               
                 1438 
                 NH(CO)NMe 2   
                 cyclpentanyl 
               
               
                 1439 
                 NH(CO)NMe 2   
                 cyclohexanyl 
               
               
                 1440 
                 NH(CO)NMe 2   
                 cycloheptanyl 
               
               
                 1441 
                 NH(CO)NMe 2   
                 phenyl 
               
               
                 1442 
                 NH(CO)NMe 2   
                 phenylmethyl 
               
               
                 1443 
                 NH(CO)NMe 2   
                 3-hydroxyphenyl 
               
               
                 1444 
                 NH(CO)NMe 2   
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1445 
                 NH(CO)NMe 2   
                 3-fluorophenyl 
               
               
                 1446 
                 NH(CO)NMe 2   
                 3-chlorophenyl 
               
               
                 1447 
                 NH(CO)NMe 2   
                 3-nitrophenyl 
               
               
                 1448 
                 NH(CO)NMe 2   
                 3-aminophenyl 
               
               
                 1449 
                 NH(CO)NMe 2   
                 3-methylsulfonamidephenyl 
               
               
                 1450 
                 NH(CO)NMe 2   
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1451 
                 NH(CO)NMe 2   
                 3-Ac—NHphenyl 
               
               
                 1452 
                 NH(CO)NMe 2   
                 3-Boc—NHphenyl 
               
               
                 1453 
                 NH(CO)NMe 2   
                 3-Cbz—NHphenyl 
               
               
                 1454 
                 NH(CO)NMe 2   
                 3-aminomethylenephenyl 
               
               
                 1455 
                 NH(CO)NMe 2   
                 3-aminoethylenephenyl 
               
               
                 1456 
                 NH(CO)NMe 2   
                 3-cyanophenyl 
               
               
                 1457 
                 NH(CO)NMe 2   
                 3-cyanomethylphenyl 
               
               
                 1458 
                 NH(CO)NMe 2   
                 3-hydroxymethylenephenyl 
               
               
                 1459 
                 NH(CO)NMe 2   
                 3-carboxylphenyl 
               
               
                 1460 
                 NH(CO)NMe 2   
                 3-mercaptophenyl 
               
               
                 1461 
                 NH(CO)NMe 2   
                 3-methoxyphenyl 
               
               
                 1462 
                 NH(CO)NMe 2   
                 3,4-methylenedioxophenyl 
               
               
                 1463 
                 NH(CO)NMe 2   
                 3-tetrazolephenyl 
               
               
                 1464 
                 NH(CO)NMe 2   
                 3-aminosulfonylphenyl 
               
               
                 1465 
                 NH(CO)NMe 2   
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1466 
                 NH(CO)NMe 2   
                 3-ethylamino-sulfonylphenyl 
               
               
                 1467 
                 NH(CO)NMe 2   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1468 
                 NH(CO)NMe 2   
                 3-methylsulfonylphenyl 
               
               
                 1469 
                 NH(CO)NMe 2   
                 4-methoxyphenyl 
               
               
                 1470 
                 NH(CO)NMe 2   
                 4-phenylphenyl 
               
               
                 1471 
                 NH(CO)NMe 2   
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1472 
                 NH(CO)NMe 2   
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1473 
                 NH(CO)NMe 2   
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1474 
                 NH(CO)NMe 2   
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1475 
                 NH(CO)NMe 2   
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1476 
                 NH(CO)NMe 2   
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1477 
                 NH(CO)NMe 2   
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1478 
                 NH(CO)NMe 2   
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1479 
                 NH(CO)NMe 2   
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1480 
                 NH(CO)NMe 2   
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1481 
                 NH(CO)NMe 2   
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1482 
                 NH(CO)NMe 2   
                 4-(2-methylphenyl)-phenyl 
               
               
                 1483 
                 NH(CO)NMe 2   
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1484 
                 NH(CO)NMe 2   
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1485 
                 NH(CO)NMe 2   
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1486 
                 NH(CO)NMe 2   
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1487 
                 NH(CO)NMe 2   
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1488 
                 NH(CO)NMe 2   
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1489 
                 NH(CO)NMe 2   
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1490 
                 NH(CO)NMe 2   
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1491 
                 NH(CO)NMe 2   
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1492 
                 NH(CO)NMe 2   
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1493 
                 NH(CO)NMe 2   
                 4-(3-methylphenyl)-phenyl 
               
               
                 1494 
                 NH(CO)NMe 2   
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1495 
                 NH(CO)NMe 2   
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1496 
                 NH(CO)NMe 2   
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1497 
                 NH(CO)NMe 2   
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1498 
                 NH(CO)NMe 2   
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1499 
                 NH(CO)NMe 2   
                 2-pyridyl 
               
               
                 1500 
                 NH(CO)NMe 2   
                 3-pyridyl 
               
               
                 1501 
                 NH(CO)NMe 2   
                 4-pyridyl 
               
               
                 1502 
                 NH(CO)NMe 2   
                 3-amino-4-pyridyl 
               
               
                 1503 
                 NH(CO)NMe 2   
                 3-hydroxy-4-pyridyl 
               
               
                 1504 
                 NH(CO)NMe 2   
                 3-imidazole 
               
               
                 1505 
                 NH(CO)NMe 2   
                 2-nitro-3-imidazole 
               
               
                 1506 
                 NH(CO)NMe 2   
                 5-thiazole 
               
               
                 1507 
                 NH(CO)NMe 2   
                 5-oxazole 
               
               
                 1508 
                 NH(CO)NMe 2   
                 4-pyazole 
               
               
                 1509 
                 NH(CO)NMe 2   
                 phenylethyl 
               
               
                 1510 
                 NH(CO)NMe 2   
                 2-aminophenylethyl 
               
               
                 1511 
                 NH(CO)NMe 2   
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1512 
                 NH(CO)NMe 2   
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1513 
                 NH(CO)NMe 2   
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1514 
                 NH(CO)NMe 2   
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1515 
                 NH(CO)NMe 2   
                 2-tetrazolephenylethyl 
               
               
                 1516 
                 NH(CO)NMe 2   
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1517 
                 NH(CO)NMe 2   
                 2-aminosulfonyl-phenylethyl 
               
               
                 1518 
                 NH(CO)NMe 2   
                 2-methoxyphenylethyl 
               
               
                 1519 
                 NH(CO)NMe 2   
                 3-aminophenylethyl 
               
               
                 1520 
                 NH(CO)NMe 2   
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1521 
                 NH(CO)NMe 2   
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1522 
                 NH(CO)NMe 2   
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1523 
                 NH(CO)NMe 2   
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1524 
                 NH(CO)NMe 2   
                 3-tetrazolephenylethyl 
               
               
                 1525 
                 NH(CO)NMe 2   
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1526 
                 NH(CO)NMe 2   
                 3-aminosulfonyl-phenylethyl 
               
               
                 1527 
                 NH(CO)NMe 2   
                 3-methoxyphenylethyl 
               
               
                 1528 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 H 
               
               
                 1529 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 methyl 
               
               
                 1530 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 ethyl 
               
               
                 1531 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 n-propyl 
               
               
                 1532 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 n-butyl 
               
               
                 1533 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 n-pentyl 
               
               
                 1534 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 n-hexanyl 
               
               
                 1535 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 n-heptanyl 
               
               
                 1536 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 isopropyl 
               
               
                 1537 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 tert-butyl 
               
               
                 1538 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 cyclopropyl 
               
               
                 1539 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 cyclobutanyl 
               
               
                 1540 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 cyclpentanyl 
               
               
                 1541 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 cyclohexanyl 
               
               
                 1542 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 cycloheptanyl 
               
               
                 1543 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 phenyl 
               
               
                 1544 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 phenylmethyl 
               
               
                 1545 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-hydroxyphenyl 
               
               
                 1546 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1547 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-fluorophenyl 
               
               
                 1548 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-chlorophenyl 
               
               
                 1549 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-nitrophenyl 
               
               
                 1550 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminophenyl 
               
               
                 1551 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methyl-sulfonamidephenyl 
               
               
                 1552 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1553 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-Ac—NHphenyl 
               
               
                 1554 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-Boc—NHphenyl 
               
               
                 1555 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-Cbz—NHphenyl 
               
               
                 1556 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminomethylenephenyl 
               
               
                 1557 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminoethylenephenyl 
               
               
                 1558 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-cyanophenyl 
               
               
                 1559 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-cyanomethylphenyl 
               
               
                 1560 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-hydroxymethylenephenyl 
               
               
                 1561 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-carboxylphenyl 
               
               
                 1562 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-mercaptophenyl 
               
               
                 1563 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methoxyphenyl 
               
               
                 1564 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3,4-methylenedioxophenyl 
               
               
                 1565 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-tetrazolephenyl 
               
               
                 1566 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminosulfonylphenyl 
               
               
                 1567 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1568 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1569 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1570 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methylsulfonylphenyl 
               
               
                 1571 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-methoxyphenyl 
               
               
                 1572 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-phenylphenyl 
               
               
                 1573 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1574 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1575 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1576 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1577 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1578 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1579 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1580 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1581 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1582 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1583 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1584 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1585 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1586 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1587 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1588 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1589 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1590 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1591 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1592 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1593 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1594 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1595 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1596 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1597 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1598 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1599 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1600 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1601 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-pyridyl 
               
               
                 1602 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-pyridyl 
               
               
                 1603 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-pyridyl 
               
               
                 1604 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-amino-4-pyridyl 
               
               
                 1605 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-hydroxy-4-pyridyl 
               
               
                 1606 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-imidazole 
               
               
                 1607 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-nitro-3-imidazole 
               
               
                 1608 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 5-thiazole 
               
               
                 1609 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 5-oxazole 
               
               
                 1610 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 4-pyazole 
               
               
                 1611 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 phenylethyl 
               
               
                 1612 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-aminophenylethyl 
               
               
                 1613 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1614 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1615 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1616 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1617 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-tetrazolephenylethyl 
               
               
                 1618 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1619 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1620 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 2-methoxyphenylethyl 
               
               
                 1621 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminophenylethyl 
               
               
                 1622 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1623 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1624 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1625 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1626 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-tetrazolephenylethyl 
               
               
                 1627 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1628 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1629 
                 NH(CO)N(CH 2 CH 2 ) 2 O 
                 3-methoxyphenylethyl 
               
               
                 1630 
                 tert-BuCONH 
                 H 
               
               
                 1631 
                 tert-BuCONH 
                 methyl 
               
               
                 1632 
                 tert-BuCONH 
                 ethyl 
               
               
                 1633 
                 tert-BuCONH 
                 n-propyl 
               
               
                 1634 
                 tert-BuCONH 
                 n-butyl 
               
               
                 1635 
                 tert-BuCONH 
                 n-pentyl 
               
               
                 1636 
                 tert-BuCONH 
                 n-hexanyl 
               
               
                 1637 
                 tert-BuCONH 
                 n-heptanyl 
               
               
                 1638 
                 tert-BuCONH 
                 isopropyl 
               
               
                 1639 
                 tert-BuCONH 
                 tert-butyl 
               
               
                 1640 
                 tert-BuCONH 
                 cyclopropyl 
               
               
                 1641 
                 tert-BuCONH 
                 cyclobutanyl 
               
               
                 1642 
                 tert-BuCONH 
                 cyclpentanyl 
               
               
                 1643 
                 tert-BuCONH 
                 cyclohexanyl 
               
               
                 1644 
                 tert-BuCONH 
                 cycloheptanyl 
               
               
                 1645 
                 tert-BuCONH 
                 phenyl 
               
               
                 1646 
                 tert-BuCONH 
                 phenylmethyl 
               
               
                 1647 
                 tert-BuCONH 
                 3-hydroxyphenyl 
               
               
                 1648 
                 tert-BuCONH 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1649 
                 tert-BuCONH 
                 3-fluorophenyl 
               
               
                 1650 
                 tert-BuCONH 
                 3-chlorophenyl 
               
               
                 1651 
                 tert-BuCONH 
                 3-nitrophenyl 
               
               
                 1652 
                 tert-BuCONH 
                 3-aminophenyl 
               
               
                 1653 
                 tert-BuCONH 
                 3-methyl-sulfonamidephenyl 
               
               
                 1654 
                 tert-BuCONH 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1655 
                 tert-BuCONH 
                 3-Ac—NHphenyl 
               
               
                 1656 
                 tert-BuCONH 
                 3-Boc—NHphenyl 
               
               
                 1657 
                 tert-BuCONH 
                 3-Cbz—NHphenyl 
               
               
                 1658 
                 tert-BuCONH 
                 3-aminomethylenephenyl 
               
               
                 1659 
                 tert-BuCONH 
                 3-aminoethylenephenyl 
               
               
                 1660 
                 tert-BuCONH 
                 3-cyanophenyl 
               
               
                 1661 
                 tert-BuCONH 
                 3-cyanomethylphenyl 
               
               
                 1662 
                 tert-BuCONH 
                 3-hydroxymethylenephenyl 
               
               
                 1663 
                 tert-BuCONH 
                 3-carboxylphenyl 
               
               
                 1664 
                 tert-BuCONH 
                 3-mercaptophenyl 
               
               
                 1665 
                 tert-BuCONH 
                 3-methoxyphenyl 
               
               
                 1666 
                 tert-BuCONH 
                 3,4-methylenedioxophenyl 
               
               
                 1667 
                 tert-BuCONH 
                 3-tetrazolephenyl 
               
               
                 1668 
                 tert-BuCONH 
                 3-aminosulfonylphenyl 
               
               
                 1669 
                 tert-BuCONH 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1670 
                 tert-BuCONH 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1671 
                 tert-BuCONH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1672 
                 tert-BuCONH 
                 3-methylsulfonylphenyl 
               
               
                 1673 
                 tert-BuCONH 
                 4-methoxyphenyl 
               
               
                 1674 
                 tert-BuCONH 
                 4-phenylphenyl 
               
               
                 1675 
                 tert-BuCONH 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1676 
                 tert-BuCONH 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1677 
                 tert-BuCONH 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1678 
                 tert-BuCONH 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1679 
                 tert-BuCONH 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1680 
                 tert-BuCONH 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1681 
                 tert-BuCONH 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1682 
                 tert-BuCONH 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1683 
                 tert-BuCONH 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1684 
                 tert-BuCONH 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1685 
                 tert-BuCONH 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1686 
                 tert-BuCONH 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1687 
                 tert-BuCONH 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1688 
                 tert-BuCONH 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1689 
                 tert-BuCONH 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1690 
                 tert-BuCONH 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1691 
                 tert-BuCONH 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1692 
                 tert-BuCONH 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1693 
                 tert-BuCONH 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1694 
                 tert-BuCONH 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1695 
                 tert-BuCONH 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1696 
                 tert-BuCONH 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1697 
                 tert-BuCONH 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1698 
                 tert-BuCONH 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1699 
                 tert-BuCONH 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1700 
                 tert-BuCONH 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1701 
                 tert-BuCONH 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1702 
                 tert-BuCONH 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1703 
                 tert-BuCONH 
                 2-pyridyl 
               
               
                 1704 
                 tert-BuCONH 
                 3-pyridyl 
               
               
                 1705 
                 tert-BuCONH 
                 4-pyridyl 
               
               
                 1706 
                 tert-BuCONH 
                 3-amino-4-pyridyl 
               
               
                 1707 
                 tert-BuCONH 
                 3-hydroxy-4-pyridyl 
               
               
                 1708 
                 tert-BuCONH 
                 3-imidazole 
               
               
                 1709 
                 tert-BuCONH 
                 2-nitro-3-imidazole 
               
               
                 1710 
                 tert-BuCONH 
                 5-thiazole 
               
               
                 1711 
                 tert-BuCONH 
                 5-oxazole 
               
               
                 1712 
                 tert-BuCONH 
                 4-pyazole 
               
               
                 1713 
                 tert-BuCONH 
                 phenylethyl 
               
               
                 1714 
                 tert-BuCONH 
                 2-aminophenylethyl 
               
               
                 1715 
                 tert-BuCONH 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1716 
                 tert-BuCONH 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1717 
                 tert-BuCONH 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1718 
                 tert-BuCONH 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1719 
                 tert-BuCONH 
                 2-tetrazolephenylethyl 
               
               
                 1720 
                 tert-BuCONH 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1721 
                 tert-BuCONH 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1722 
                 tert-BuCONH 
                 2-methoxyphenylethyl 
               
               
                 1723 
                 tert-BuCONH 
                 3-aminophenylethyl 
               
               
                 1724 
                 tert-BuCONH 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1725 
                 tert-BuCONH 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1726 
                 tert-BuCONH 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1727 
                 tert-BuCONH 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1728 
                 tert-BuCONH 
                 3-tetrazolephenylethyl 
               
               
                 1729 
                 tert-BuCONH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1730 
                 tert-BuCONH 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1731 
                 tert-BuCONH 
                 3-methoxyphenylethyl 
               
               
                 1732 
                 c-C 3 H 5 CONH 
                 H 
               
               
                 1733 
                 c-C 3 H 5 CONH 
                 methyl 
               
               
                 1734 
                 c-C 3 H 5 CONH 
                 ethyl 
               
               
                 1735 
                 c-C 3 H 5 CONH 
                 n-propyl 
               
               
                 1736 
                 c-C 3 H 5 CONH 
                 n-butyl 
               
               
                 1737 
                 c-C 3 H 5 CONH 
                 n-pentyl 
               
               
                 1738 
                 c-C 3 H 5 CONH 
                 n-hexanyl 
               
               
                 1739 
                 c-C 3 H 5 CONH 
                 n-heptanyl 
               
               
                 1740 
                 c-C 3 H 5 CONH 
                 isopropyl 
               
               
                 1741 
                 c-C 3 H 5 CONH 
                 tert-butyl 
               
               
                 1742 
                 c-C 3 H 5 CONH 
                 cyclopropyl 
               
               
                 1743 
                 c-C 3 H 5 CONH 
                 cyclobutanyl 
               
               
                 1744 
                 c-C 3 H 5 CONH 
                 cyclpentanyl 
               
               
                 1745 
                 c-C 3 H 5 CONH 
                 cyclohexanyl 
               
               
                 1746 
                 c-C 3 H 5 CONH 
                 cycloheptanyl 
               
               
                 1747 
                 c-C 3 H 5 CONH 
                 phenyl 
               
               
                 1748 
                 c-C 3 H 5 CONH 
                 phenylmethyl 
               
               
                 1749 
                 c-C 3 H 5 CONH 
                 3-hydroxyphenyl 
               
               
                 1750 
                 c-C 3 H 5 CONH 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1751 
                 c-C 3 H 5 CONH 
                 3-fluorophenyl 
               
               
                 1752 
                 c-C 3 H 5 CONH 
                 3-chlorophenyl 
               
               
                 1753 
                 c-C 3 H 5 CONH 
                 3-nitrophenyl 
               
               
                 1754 
                 c-C 3 H 5 CONH 
                 3-aminophenyl 
               
               
                 1755 
                 c-C 3 H 5 CONH 
                 3-methyl-sulfonamidephenyl 
               
               
                 1756 
                 c-C 3 H 5 CONH 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1757 
                 c-C 3 H 5 CONH 
                 3-Ac—NHphenyl 
               
               
                 1758 
                 c-C 3 H 5 CONH 
                 3-Boc—NHphenyl 
               
               
                 1759 
                 c-C 3 H 5 CONH 
                 3-Cbz—NHphenyl 
               
               
                 1760 
                 c-C 3 H 5 CONH 
                 3-aminomethylenephenyl 
               
               
                 1761 
                 c-C 3 H 5 CONH 
                 3-aminoethylenephenyl 
               
               
                 1762 
                 c-C 3 H 5 CONH 
                 3-cyanophenyl 
               
               
                 1763 
                 c-C 3 H 5 CONH 
                 3-cyanomethylphenyl 
               
               
                 1764 
                 c-C 3 H 5 CONH 
                 3-hydroxymethylenephenyl 
               
               
                 1765 
                 c-C 3 H 5 CONH 
                 3-carboxylphenyl 
               
               
                 1766 
                 c-C 3 H 5 CONH 
                 3-mercaptophenyl 
               
               
                 1767 
                 c-C 3 H 5 CONH 
                 3-methoxyphenyl 
               
               
                 1768 
                 c-C 3 H 5 CONH 
                 3,4-methylenedioxophenyl 
               
               
                 1769 
                 c-C 3 H 5 CONH 
                 3-tetrazolephenyl 
               
               
                 1770 
                 c-C 3 H 5 CONH 
                 3-aminosulfonylphenyl 
               
               
                 1771 
                 c-C 3 H 5 CONH 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1772 
                 c-C 3 H 5 CONH 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1773 
                 c-C 3 H 5 CONH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1774 
                 c-C 3 H 5 CONH 
                 3-methylsulfonylphenyl 
               
               
                 1775 
                 c-C 3 H 5 CONH 
                 4-methoxyphenyl 
               
               
                 1776 
                 c-C 3 H 5 CONH 
                 4-phenylphenyl 
               
               
                 1777 
                 c-C 3 H 5 CONH 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1778 
                 c-C 3 H 5 CONH 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1779 
                 c-C 3 H 5 CONH 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1780 
                 c-C 3 H 5 CONH 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1781 
                 c-C 3 H 5 CONH 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1782 
                 c-C 3 H 5 CONH 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1783 
                 c-C 3 H 5 CONH 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1784 
                 c-C 3 H 5 CONH 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1785 
                 c-C 3 H 5 CONH 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1786 
                 c-C 3 H 5 CONH 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1787 
                 c-C 3 H 5 CONH 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1788 
                 c-C 3 H 5 CONH 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1789 
                 c-C 3 H 5 CONH 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1790 
                 c-C 3 H 5 CONH 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1791 
                 c-C 3 H 5 CONH 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1792 
                 c-C 3 H 5 CONH 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1793 
                 c-C 3 H 5 CONH 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1794 
                 c-C 3 H 5 CONH 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1795 
                 c-C 3 H 5 CONH 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1796 
                 c-C 3 H 5 CONH 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1797 
                 c-C 3 H 5 CONH 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1798 
                 c-C 3 H 5 CONH 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1799 
                 c-C 3 H 5 CONH 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1800 
                 c-C 3 H 5 CONH 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1801 
                 c-C 3 H 5 CONH 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1802 
                 c-C 3 H 5 CONH 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1803 
                 c-C 3 H 5 CONH 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1804 
                 c-C 3 H 5 CONH 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1805 
                 c-C 3 H 5 CONH 
                 2-pyridyl 
               
               
                 1806 
                 c-C 3 H 5 CONH 
                 3-pyridyl 
               
               
                 1807 
                 c-C 3 H 5 CONH 
                 4-pyridyl 
               
               
                 1808 
                 c-C 3 H 5 CONH 
                 3-amino-4-pyridyl 
               
               
                 1809 
                 c-C 3 H 5 CONH 
                 3-hydroxy-4-pyridyl 
               
               
                 1810 
                 c-C 3 H 5 CONH 
                 3-imidazole 
               
               
                 1811 
                 c-C 3 H 5 CONH 
                 2-nitro-3-imidazole 
               
               
                 1812 
                 c-C 3 H 5 CONH 
                 5-thiazole 
               
               
                 1813 
                 c-C 3 H 5 CONH 
                 5-oxazole 
               
               
                 1814 
                 c-C 3 H 5 CONH 
                 4-pyazole 
               
               
                 1815 
                 c-C 3 H 5 CONH 
                 phenylethyl 
               
               
                 1816 
                 c-C 3 H 5 CONH 
                 2-aminophenylethyl 
               
               
                 1817 
                 c-C 3 H 5 CONH 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1818 
                 c-C 3 H 5 CONH 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1819 
                 c-C 3 H 5 CONH 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1820 
                 c-C 3 H 5 CONH 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1821 
                 c-C 3 H 5 CONH 
                 2-tetrazolephenylethyl 
               
               
                 1822 
                 c-C 3 H 5 CONH 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1823 
                 c-C 3 H 5 CONH 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1824 
                 c-C 3 H 5 CONH 
                 2-methoxyphenylethyl 
               
               
                 1825 
                 c-C 3 H 5 CONH 
                 3-aminophenylethyl 
               
               
                 1826 
                 c-C 3 H 5 CONH 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1827 
                 c-C 3 H 5 CONH 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1828 
                 c-C 3 H 5 CONH 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1829 
                 c-C 3 H 5 CONH 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1830 
                 c-C 3 H 5 CONH 
                 3-tetrazolephenylethyl 
               
               
                 1831 
                 c-C 3 H 5 CONH 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1832 
                 c-C 3 H 5 CONH 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1833 
                 c-C 3 H 5 CONH 
                 3-methoxyphenylethyl 
               
               
                 1834 
               
               
                 1835 
                   
                 H 
               
               
                 1836 
                 ″ 
                 methyl 
               
               
                 1837 
                 ″ 
                 ethyl 
               
               
                 1838 
                 ″ 
                 n-propyl 
               
               
                 1839 
                 ″ 
                 n-butyl 
               
               
                 1840 
                 ″ 
                 n-pentyl 
               
               
                 1841 
                 ″ 
                 n-hexanyl 
               
               
                 1842 
                 ″ 
                 n-heptanyl 
               
               
                 1843 
                 ″ 
                 isopropyl 
               
               
                 1844 
                 ″ 
                 tert-butyl 
               
               
                 1845 
                 ″ 
                 cyclopropyl 
               
               
                 1846 
                 ″ 
                 cyclobutanyl 
               
               
                 1847 
                 ″ 
                 cyclpentanyl 
               
               
                 1848 
                 ″ 
                 cyclohexanyl 
               
               
                 1849 
                 ″ 
                 cycloheptanyl 
               
               
                 1850 
                 ″ 
                 phenyl 
               
               
                 1851 
                 ″ 
                 phenylmethyl 
               
               
                 1852 
                 ″ 
                 3-hydroxyphenyl 
               
               
                 1853 
                 ″ 
                 3-hydroxy-4-methoxyphenyl 
               
               
                 1854 
                 ″ 
                 3-fluorophenyl 
               
               
                 1855 
                 ″ 
                 3-chlorophenyl 
               
               
                 1856 
                 ″ 
                 3-nitrophenyl 
               
               
                 1857 
                 ″ 
                 3-aminophenyl 
               
               
                 1858 
                 ″ 
                 3-methyl-sulfonamidephenyl 
               
               
                 1859 
                 ″ 
                 3-trifluoro- 
               
               
                   
                   
                 methylsulfonamidephenyl 
               
               
                 1860 
                 ″ 
                 3-Ac—NHphenyl 
               
               
                 1861 
                 ″ 
                 3-Boc—NHphenyl 
               
               
                 1862 
                 ″ 
                 3-Cbz—NHphenyl 
               
               
                 1863 
                 ″ 
                 3-aminomethylenephenyl 
               
               
                 1864 
                 ″ 
                 3-aminoethylenephenyl 
               
               
                 1865 
                 ″ 
                 3-cyanophenyl 
               
               
                 1866 
                 ″ 
                 3-cyanomethylphenyl 
               
               
                 1867 
                 ″ 
                 3-hydroxymethylenephenyl 
               
               
                 1868 
                 ″ 
                 3-carboxylphenyl 
               
               
                 1869 
                 ″ 
                 3-mercaptophenyl 
               
               
                 1870 
                 ″ 
                 3-methoxyphenyl 
               
               
                 1871 
                 ″ 
                 3,4-methylenedioxophenyl 
               
               
                 1872 
                 ″ 
                 3-tetrazolephenyl 
               
               
                 1873 
                 ″ 
                 3-aminosulfonylphenyl 
               
               
                 1874 
                 ″ 
                 3-methylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1875 
                 ″ 
                 3-ethylamino-sulfonylphenyl 
               
               
                 1876 
                 ″ 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenyl 
               
               
                 1877 
                 ″ 
                 3-methylsulfonylphenyl 
               
               
                 1878 
                 ″ 
                 4-methoxyphenyl 
               
               
                 1879 
                 ″ 
                 4-phenylphenyl 
               
               
                 1880 
                 ″ 
                 4-(2-hydroxy- 
               
               
                   
                   
                 methylenephenyl)-phenyl 
               
               
                 1881 
                 ″ 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1882 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1883 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                 1884 
                 ″ 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1885 
                 ″ 
                 4-(2-chlorophenyl)-phenyl 
               
               
                 1886 
                 ″ 
                 4-(2-fluorophenyl)-phenyl 
               
               
                 1887 
                 ″ 
                 4-(2,4-dichlorophenyl)-phenyl 
               
               
                 1888 
                 ″ 
                 4-(2,6-dichlorophenyl)-phenyl 
               
               
                 1889 
                 ″ 
                 4-(3,5-dichlorophenyl)-phenyl 
               
               
                 1890 
                 ″ 
                 4-(2,3-dichlorophenyl)-phenyl 
               
               
                 1891 
                 ″ 
                 4-(2-methylphenyl)-phenyl 
               
               
                 1892 
                 ″ 
                 4-(2-tetrazole-phenyl)-phenyl 
               
               
                 1893 
                 ″ 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                 1894 
                 ″ 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                 1895 
                 ″ 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                 1896 
                 ″ 
                 4-(2-amino-phenyl)-phenyl 
               
               
                 1897 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1898 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1899 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1900 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1901 
                 ″ 
                 4-(2-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1902 
                 ″ 
                 4-(3-methylphenyl)-phenyl 
               
               
                 1903 
                 ″ 
                 4-(3-isopropylphenyl)-phenyl 
               
               
                 1904 
                 ″ 
                 4-(3-trifluoromethyl- 
               
               
                   
                   
                 sulfonyl-amino-phenyl)- 
               
               
                   
                   
                 phenyl 
               
               
                 1905 
                 ″ 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                 phenyl)-phenyl 
               
               
                 1906 
                 ″ 
                 4-(3-amino-phenyl)-phenyl 
               
               
                 1907 
                 ″ 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                 1908 
                 ″ 
                 2-pyridyl 
               
               
                 1909 
                 ″ 
                 3-pyridyl 
               
               
                 1910 
                 ″ 
                 4-pyridyl 
               
               
                 1911 
                 ″ 
                 3-amino-4-pyridyl 
               
               
                 1912 
                 ″ 
                 3-hydroxy-4-pyridyl 
               
               
                 1913 
                 ″ 
                 3-imidazole 
               
               
                 1914 
                 ″ 
                 2-nitro-3-imidazole 
               
               
                 1915 
                 ″ 
                 5-thiazole 
               
               
                 1916 
                 ″ 
                 5-oxazole 
               
               
                 1917 
                 ″ 
                 4-pyazole 
               
               
                 1918 
                 ″ 
                 phenylethyl 
               
               
                 1919 
                 ″ 
                 2-aminophenylethyl 
               
               
                 1920 
                 ″ 
                 2-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1921 
                 ″ 
                 2-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1922 
                 ″ 
                 2-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1923 
                 ″ 
                 2-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1924 
                 ″ 
                 2-tetrazolephenylethyl 
               
               
                 1925 
                 ″ 
                 2-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1926 
                 ″ 
                 2-aminosulfonyl-phenylethyl 
               
               
                 1927 
                 ″ 
                 2-methoxyphenylethyl 
               
               
                 1928 
                 ″ 
                 3-aminophenylethyl 
               
               
                 1929 
                 ″ 
                 3-methylsulfonylamino- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1930 
                 ″ 
                 3-trifluoromethylsulfonyl- 
               
               
                   
                   
                 amino-phenylethyl 
               
               
                 1931 
                 ″ 
                 3-hydroxymethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1932 
                 ″ 
                 3-aminomethylene- 
               
               
                   
                   
                 phenylethyl 
               
               
                 1933 
                 ″ 
                 3-tetrazolephenylethyl 
               
               
                 1934 
                 ″ 
                 3-tert-butylamino- 
               
               
                   
                   
                 sulfonylphenylethyl 
               
               
                 1935 
                 ″ 
                 3-aminosulfonyl-phenylethyl 
               
               
                 1936 
                 ″ 
                 3-methoxyphenylethyl 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
             
             
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 I 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 II 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 III 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 IV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 V 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 IX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 X 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XVIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XIX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XX 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXIII 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXIV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXV 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXVI 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 XXVII 
               
               
                   
               
             
          
           
               
                 Ex # 
                 R3 
                 Ms 
                 Ex # 
                 R3 
                 Ms 
               
               
                   
               
               
                 2000 
                 H 
                   
                 2001 
                 4-(2- 
               
               
                   
                   
                   
                   
                 aminosufonylphenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2002 
                 methyl 
                   
                 2003 
                 4-(2-chlorophenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2004 
                 ethyl 
                   
                 2005 
                 4-(2-fluorophenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2006 
                 n-propyl 
                   
                 2007 
                 4-(2,4- 
               
               
                   
                   
                   
                   
                 dichlorophenyl)-phenyl 
               
               
                 2008 
                 n-butyl 
                   
                 2009 
                 4-(2,6- 
               
               
                   
                   
                   
                   
                 dichlorophenyl)-phenyl 
               
               
                 2010 
                 n-pentyl 
                   
                 2011 
                 4-(3,5- 
               
               
                   
                   
                   
                   
                 dichlorophenyl)-phenyl 
               
               
                 2012 
                 n-hexanyl 
                   
                 2013 
                 4-(2,3- 
               
               
                   
                   
                   
                   
                 dichlorophenyl)-phenyl 
               
               
                 2014 
                 n-heptanyl 
                   
                 2015 
                 4-(2-methylphenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2016 
                 isopropyl 
                   
                 2017 
                 4-(2-tetrazole- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2018 
                 tert-butyl 
                   
                 2019 
                 4-(2-methoxy-phenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2020 
                 cyclopropyl 
                   
                 2021 
                 4-(2-tmethyl-phenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2022 
                 cyclobutanyl 
                   
                 2023 
                 4-(2-formyl-phenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2024 
                 cyclpentanyl 
                   
                 2025 
                 4-(2-amino-phenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2026 
                 cyclohexanyl 
                   
                 2027 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2028 
                 cycloheptanyl 
                   
                 2029 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2030 
                 phenyl 
                   
                 2031 
                 4-(2-propylamino- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2032 
                 phenylmethyl 
                   
                 2033 
                 4-(2- 
               
               
                   
                   
                   
                   
                 methylsulfonylamino- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2034 
                 3-hydroxyphenyl 
                   
                 2035 
                 4-(2- 
               
               
                   
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                 2036 
                 3-hydroxy-4- 
                   
                 2037 
                 4-(3-methylphenyl)- 
               
               
                   
                 methoxyphenyl 
                   
                   
                 phenyl 
               
               
                 2038 
                 3-fluorophenyl 
                   
                 2039 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2040 
                 3-chlorophenyl 
                   
                 2041 
                 4-(3- 
               
               
                   
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                 2042 
                 3-nitrophenyl 
                   
                 2043 
                 4-(3- 
               
               
                   
                   
                   
                   
                 methylsulfonylamino- 
               
               
                   
                   
                   
                   
                 phenyl)-phenyl 
               
               
                 2044 
                 3-aminophenyl 
                   
                 2045 
                 4-(3-amino-phenyl)- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 2046 
                 3-methylsul- 
                   
                 2047 
                 4-(3-nitro-phenyl)- 
               
               
                   
                 fonamidephenyl 
                   
                   
                 phenyl 
               
               
                 2048 
                 3-trifluoro-methyl- 
                   
                 2049 
                 2-pyridyl 
               
               
                   
                 sulfonamidephenyl 
               
               
                 2050 
                 3-Ac—NHphenyl 
                   
                 2051 
                 3-pyridyl 
               
               
                 2052 
                 3-Boc—NHphenyl 
                   
                 2053 
                 4-pyridyl 
               
               
                 2054 
                 3-Cbz—NHphenyl 
                   
                 2055 
                 3-amino-4-pyridyl 
               
               
                 2056 
                 3-aminomethylene- 
                   
                 2057 
                 3-hydroxy-4-pyridyl 
               
               
                   
                 phenyl 
               
               
                 2058 
                 3-amino- 
                   
                 2059 
                 3-imidazole 
               
               
                   
                 ethylenephenyl 
               
               
                 2060 
                 3-cyanophenyl 
                   
                 2061 
                 2-nitro-3-imidazole 
               
               
                 2062 
                 3-cyanomethylphenyl 
                   
                 2063 
                 5-thiazole 
               
               
                 2064 
                 3-hydroxy- 
                   
                 2065 
                 5-oxazole 
               
               
                   
                 methylenephenyl 
               
               
                 2066 
                 3-carboxylphenyl 
                   
                 2067 
                 4-pyazole 
               
               
                 2068 
                 3-mercaptophenyl 
                   
                 2069 
                 phenylethyl 
               
               
                 2070 
                 3-methoxyphenyl 
                   
                 2071 
                 2-aminophenylethyl 
               
               
                 2072 
                 3,4-methylenedioxo- 
                   
                 2073 
                 2-methylsulfonyl- 
               
               
                   
                 phenyl 
                   
                   
                 amino-phenylethyl 
               
               
                 2074 
                 3-tetrazolephenyl 
                   
                 2075 
                 2- 
               
               
                   
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                   
                 amino-phenylethyl 
               
               
                 2076 
                 3-aminosulfonylphenyl 
                   
                 2077 
                 2-hydroxymethylene- 
               
               
                   
                   
                   
                   
                 phenylethyl 
               
               
                 2078 
                 3-methylamino- 
                   
                 2079 
                 2-aminomethylene- 
               
               
                   
                 sulfonylphenyl 
                   
                   
                 phenylethyl 
               
               
                 2080 
                 3-ethylamino- 
                   
                 2081 
                 2-tetrazole- 
               
               
                   
                 sulfonylphenyl 
                   
                   
                 phenylethyl 
               
               
                 2082 
                 3-tert-butylamino- 
                   
                 2083 
                 2-tertbutylamino- 
               
               
                   
                 sulfonylphenyl 
                   
                   
                 sulfonylphenylethyl 
               
               
                 2084 
                 3-methylsulfonyl- 
                   
                 2085 
                 2-aminosulfonyl- 
               
               
                   
                 phenyl 
                   
                   
                 phenylethyl 
               
               
                 2086 
                 4-methoxyphenyl 
                   
                 2087 
                 2-methoxy-phenylethyl 
               
               
                 2088 
                 4-phenylphenyl 
                   
                 2089 
                 3-aminophenylethyl 
               
               
                 2090 
                 4-(2-hydroxymethyl- 
                   
                 2091 
                 3-methylsulfonyl- 
               
               
                   
                 enephenyl)-phenyl 
                   
                   
                 amino-phenylethyl 
               
               
                 2092 
                 4-(2-tert-butyl- 
                   
                 2093 
                 3- 
               
               
                   
                 aminosufonylphenyl)- 
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                 phenyl 
                   
                   
                 amino-phenylethyl 
               
               
                 2094 
                 4-(2-methylamino- 
                   
                 2095 
                 3-hydroxymethylene- 
               
               
                   
                 sufonylphenyl)-phenyl 
                   
                   
                 phenylethyl 
               
               
                 2096 
                 4-(2-ethylamino- 
                   
                 2097 
                 3-aminomethylene- 
               
               
                   
                 sufonylphenyl)-phenyl 
                   
                   
                 phenylethyl 
               
               
                 2098 
                   
                   
                 2099 
                 3-tetrazole- 
               
               
                   
                   
                   
                   
                 phenylethyl 
               
               
                 2100 
                   
                   
                 2101 
                 3-tert-butylamino- 
               
               
                   
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                 2102 
                   
                   
                 2103 
                 3-aminosulfonyl- 
               
               
                   
                   
                   
                   
                 phenylethyl 
               
               
                 2104 
                   
                   
                 2105 
                 3-methoxy-phenylethyl 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
             
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
             
             
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 I 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 II 
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 III 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 IV 
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 V 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 VI 
               
               
                   
               
             
          
           
               
                   
                 Ex # 
                 R2 
                 R3 
               
               
                   
                   
               
               
                   
                 2500 
                 n-Bu 
                 H 
               
               
                   
                 2501 
                 ″ 
                 methyl 
               
               
                   
                 2502 
                 ″ 
                 ethyl 
               
               
                   
                 2503 
                 ″ 
                 n-propyl 
               
               
                   
                 2504 
                 ″ 
                 n-butyl 
               
               
                   
                 2505 
                 ″ 
                 n-pentyl 
               
               
                   
                 2506 
                 ″ 
                 n-hexanyl 
               
               
                   
                 2507 
                 ″ 
                 n-heptanyl 
               
               
                   
                 2508 
                 ″ 
                 isopropyl 
               
               
                   
                 2509 
                 ″ 
                 tert-butyl 
               
               
                   
                 2510 
                 ″ 
                 cyclopropyl 
               
               
                   
                 2511 
                 ″ 
                 cyclobutanyl 
               
               
                   
                 2512 
                 ″ 
                 cyclpentanyl 
               
               
                   
                 2513 
                 ″ 
                 cyclohexanyl 
               
               
                   
                 2514 
                 ″ 
                 cycloheptanyl 
               
               
                   
                 2515 
                 ″ 
                 phenyl 
               
               
                   
                 2516 
                 ″ 
                 phenylmethyl 
               
               
                   
                 2517 
                 ″ 
                 3-hydroxyphenyl 
               
               
                   
                 2518 
                 ″ 
                 3-hydroxy-4-methoxyphenyl 
               
               
                   
                 2519 
                 ″ 
                 3-fluorophenyl 
               
               
                   
                 2520 
                 ″ 
                 3-chlorophenyl 
               
               
                   
                 2521 
                 ″ 
                 3-nitrophenyl 
               
               
                   
                 2522 
                 ″ 
                 3-aminophenyl 
               
               
                   
                 2523 
                 ″ 
                 3-methyl-sulfonamidephenyl 
               
               
                   
                 2524 
                 ″ 
                 3-trifluoro-methyl- 
               
               
                   
                   
                   
                 sulfonamidephenyl 
               
               
                   
                 2525 
                 ″ 
                 3-Ac—NHphenyl 
               
               
                   
                 2526 
                 ″ 
                 3-Boc—NHphenyl 
               
               
                   
                 2527 
                 ″ 
                 3-Cbz—NHphenyl 
               
               
                   
                 2528 
                 ″ 
                 3-aminomethylenephenyl 
               
               
                   
                 2529 
                 ″ 
                 3-aminoethylenephenyl 
               
               
                   
                 2530 
                 ″ 
                 3-cyanophenyl 
               
               
                   
                 2531 
                 ″ 
                 3-cyanomethylphenyl 
               
               
                   
                 2532 
                 ″ 
                 3-hydroxy-methylenephenyl 
               
               
                   
                 2533 
                 ″ 
                 3-carboxylphenyl 
               
               
                   
                 2534 
                 ″ 
                 3-mercaptophenyl 
               
               
                   
                 2535 
                 ″ 
                 3-methoxyphenyl 
               
               
                   
                 2536 
                 ″ 
                 3,4-methylene-dioxophenyl 
               
               
                   
                 2537 
                 ″ 
                 3-tetrazolephenyl 
               
               
                   
                 2538 
                 ″ 
                 3-aminosulfonylphenyl 
               
               
                   
                 2539 
                 ″ 
                 3-methylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2540 
                 ″ 
                 3-ethylamino-sulfonylphenyl 
               
               
                   
                 2541 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2542 
                 ″ 
                 3-methylsulfonylphenyl 
               
               
                   
                 2543 
                 ″ 
                 4-methoxyphenyl 
               
               
                   
                 2544 
                 ″ 
                 4-phenylphenyl 
               
               
                   
                 2545 
                 ″ 
                 4-(2-hydroxymethylene- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2546 
                 ″ 
                 4-(2-tertbutylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2547 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2548 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2549 
                 ″ 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2550 
                 ″ 
                 4-(2-chlorophenyl)-phenyl 
               
               
                   
                 2551 
                 ″ 
                 4-(2-fluorophenyl)-phenyl 
               
               
                   
                 2552 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2553 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2554 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2555 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2556 
                 ″ 
                 4-(2-methylphenyl)-phenyl 
               
               
                   
                 2557 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2558 
                 ″ 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                   
                 2559 
                 ″ 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                   
                 2560 
                 ″ 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                   
                 2561 
                 ″ 
                 4-(2-amino-phenyl)-phenyl 
               
               
                   
                 2562 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2563 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2564 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2565 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2566 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2567 
                 ″ 
                 4-(3-methylphenyl)-phenyl 
               
               
                   
                 2568 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2569 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2570 
                 ″ 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2571 
                 ″ 
                 4-(3-amino-phenyl)-phenyl 
               
               
                   
                 2572 
                 ″ 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                   
                 2573 
                 ″ 
                 2-pyridyl 
               
               
                   
                 2574 
                 ″ 
                 3-pyridyl 
               
               
                   
                 2575 
                 ″ 
                 4-pyridyl 
               
               
                   
                 2576 
                 ″ 
                 3-amino-4-pyridyl 
               
               
                   
                 2577 
                 ″ 
                 3-hydroxy-4-pyridyl 
               
               
                   
                 2578 
                 ″ 
                 3-imidazole 
               
               
                   
                 2579 
                 ″ 
                 2-nitro-3-imidazole 
               
               
                   
                 2580 
                 ″ 
                 5-thiazole 
               
               
                   
                 2581 
                 ″ 
                 5-oxazole 
               
               
                   
                 2582 
                 ″ 
                 4-pyazole 
               
               
                   
                 2583 
                 ″ 
                 phenylethyl 
               
               
                   
                 2584 
                 ″ 
                 2-aminophenylethyl 
               
               
                   
                 2585 
                 ″ 
                 2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2586 
                 ″ 
                 2-trifluoromethyl- 
               
               
                   
                   
                   
                 sulfonylamino-phenylethyl 
               
               
                   
                 2587 
                 ″ 
                 2-hydroxy- 
               
               
                   
                   
                   
                 methylenephenylethyl 
               
               
                   
                 2588 
                 ″ 
                 2-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2589 
                 ″ 
                 2-tetrazolephenylethyl 
               
               
                   
                 2590 
                 ″ 
                 2-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2591 
                 ″ 
                 2-aminosulfonyl-phenylethyl 
               
               
                   
                 2592 
                 ″ 
                 2-methoxyphenylethyl 
               
               
                   
                 2593 
                 ″ 
                 3-aminophenylethyl 
               
               
                   
                 2594 
                 ″ 
                 3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2595 
                 ″ 
                 3-trifluoromethyl- 
               
               
                   
                   
                   
                 sulfonylamino-phenylethyl 
               
               
                   
                 2596 
                 ″ 
                 3-hydroxymethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2597 
                 ″ 
                 3-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2598 
                 ″ 
                 3-tetrazolephenylethyl 
               
               
                   
                 2599 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2600 
                 ″ 
                 3-aminosulfonyl-phenylethyl 
               
               
                   
                 2601 
                 ″ 
                 3-methoxyphenylethyl 
               
               
                   
                 2602 
                 ″ 
                 4-phenylphenylmethyl 
               
               
                   
                 2603 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 hydroxymethylenephenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2604 
                 ″ 
                 4-(2-tert-butyl- 
               
               
                   
                   
                   
                 aminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2605 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenylmethyl 
               
               
                   
                 2606 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenylmethyl 
               
               
                   
                 2607 
                 ″ 
                 4-(2-aminosufonylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2608 
                 ″ 
                 4-(2-chlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2609 
                 ″ 
                 4-(2-fluorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2610 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2611 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2612 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2613 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2614 
                 ″ 
                 4-(2-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2615 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2616 
                 ″ 
                 4-(2-methoxy-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2617 
                 ″ 
                 4-(2-tmethyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2618 
                 ″ 
                 4-(2-formyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2619 
                 ″ 
                 4-(2-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2620 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2621 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2622 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2623 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2624 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2625 
                 ″ 
                 4-(3-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2626 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2627 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2628 
                 ″ 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2629 
                 ″ 
                 4-(3-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2630 
                 ″ 
                 4-(3-nitro-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2631 
               
               
                   
                 2632 
                 CH 3   
                 H 
               
               
                   
                 2633 
                 ″ 
                 methyl 
               
               
                   
                 2634 
                 ″ 
                 ethyl 
               
               
                   
                 2635 
                 ″ 
                 n-propyl 
               
               
                   
                 2636 
                 ″ 
                 n-butyl 
               
               
                   
                 2637 
                 ″ 
                 n-pentyl 
               
               
                   
                 2638 
                 ″ 
                 n-hexanyl 
               
               
                   
                 2639 
                 ″ 
                 n-heptanyl 
               
               
                   
                 2640 
                 ″ 
                 isopropyl 
               
               
                   
                 2641 
                 ″ 
                 tert-butyl 
               
               
                   
                 2642 
                 ″ 
                 cyclopropyl 
               
               
                   
                 2643 
                 ″ 
                 cyclobutanyl 
               
               
                   
                 2644 
                 ″ 
                 cyclpentanyl 
               
               
                   
                 2645 
                 ″ 
                 cyclohexanyl 
               
               
                   
                 2646 
                 ″ 
                 cycloheptanyl 
               
               
                   
                 2647 
                 ″ 
                 phenyl 
               
               
                   
                 2648 
                 ″ 
                 phenylmethyl 
               
               
                   
                 2649 
                 ″ 
                 3-hydroxyphenyl 
               
               
                   
                 2650 
                 ″ 
                 3-hydroxy-4-methoxyphenyl 
               
               
                   
                 2651 
                 ″ 
                 3-fluorophenyl 
               
               
                   
                 2652 
                 ″ 
                 3-chlorophenyl 
               
               
                   
                 2653 
                 ″ 
                 3-nitrophenyl 
               
               
                   
                 2654 
                 ″ 
                 3-aminophenyl 
               
               
                   
                 2655 
                 ″ 
                 3-methyl-sulfonamidephenyl 
               
               
                   
                 2656 
                 ″ 
                 3-trifluoro- 
               
               
                   
                   
                   
                 methylsulfonamidephenyl 
               
               
                   
                 2657 
                 ″ 
                 3-Ac—NHphenyl 
               
               
                   
                 2658 
                 ″ 
                 3-Boc—NHphenyl 
               
               
                   
                 2659 
                 ″ 
                 3-Cbz—NHphenyl 
               
               
                   
                 2660 
                 ″ 
                 3-aminomethylenephenyl 
               
               
                   
                 2661 
                 ″ 
                 3-aminoethylenephenyl 
               
               
                   
                 2662 
                 ″ 
                 3-cyanophenyl 
               
               
                   
                 2663 
                 ″ 
                 3-cyanomethylphenyl 
               
               
                   
                 2664 
                 ″ 
                 3-hydroxy-methylenephenyl 
               
               
                   
                 2665 
                 ″ 
                 3-carboxylphenyl 
               
               
                   
                 2666 
                 ″ 
                 3-mercaptophenyl 
               
               
                   
                 2667 
                 ″ 
                 3-methoxyphenyl 
               
               
                   
                 2668 
                 ″ 
                 3,4-methylene-dioxophenyl 
               
               
                   
                 2669 
                 ″ 
                 3-tetrazolephenyl 
               
               
                   
                 2670 
                 ″ 
                 3-aminosulfonylphenyl 
               
               
                   
                 2671 
                 ″ 
                 3-methylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2672 
                 ″ 
                 3-ethylamino-sulfonylphenyl 
               
               
                   
                 2673 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2674 
                 ″ 
                 3-methylsulfonylphenyl 
               
               
                   
                 2675 
                 ″ 
                 4-methoxyphenyl 
               
               
                   
                 2676 
                 ″ 
                 4-phenylphenyl 
               
               
                   
                 2677 
                 ″ 
                 4-(2-hydroxymethylene- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2678 
                 ″ 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2679 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2680 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2681 
                 ″ 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2682 
                 ″ 
                 4-(2-chlorophenyl)-phenyl 
               
               
                   
                 2683 
                 ″ 
                 4-(2-fluorophenyl)-phenyl 
               
               
                   
                 2684 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2685 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2686 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2687 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2688 
                 ″ 
                 4-(2-methylphenyl)-phenyl 
               
               
                   
                 2689 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2690 
                 ″ 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                   
                 2691 
                 ″ 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                   
                 2692 
                 ″ 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                   
                 2693 
                 ″ 
                 4-(2-amino-phenyl)-phenyl 
               
               
                   
                 2694 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2695 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2696 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2697 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2698 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2699 
                 ″ 
                 4-(3-methylphenyl)-phenyl 
               
               
                   
                 2700 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2701 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2702 
                 ″ 
                 4-(3-methylsulfonyl-amino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2703 
                 ″ 
                 4-(3-amino-phenyl)-phenyl 
               
               
                   
                 2704 
                 ″ 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                   
                 2705 
                 ″ 
                 2-pyridyl 
               
               
                   
                 2706 
                 ″ 
                 3-pyridyl 
               
               
                   
                 2707 
                 ″ 
                 4-pyridyl 
               
               
                   
                 2708 
                 ″ 
                 3-amino-4-pyridyl 
               
               
                   
                 2709 
                 ″ 
                 3-hydroxy-4-pyridyl 
               
               
                   
                 2710 
                 ″ 
                 3-imidazole 
               
               
                   
                 2711 
                 ″ 
                 2-nitro-3-imidazole 
               
               
                   
                 2712 
                 ″ 
                 5-thiazole 
               
               
                   
                 2713 
                 ″ 
                 5-oxazole 
               
               
                   
                 2714 
                 ″ 
                 4-pyazole 
               
               
                   
                 2715 
                 ″ 
                 phenylethyl 
               
               
                   
                 2716 
                 ″ 
                 2-aminophenylethyl 
               
               
                   
                 2717 
                 ″ 
                 2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2718 
                 ″ 
                 2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2719 
                 ″ 
                 2-hydroxymethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2720 
                 ″ 
                 2-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2721 
                 ″ 
                 2-tetrazolephenylethyl 
               
               
                   
                 2722 
                 ″ 
                 2-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2723 
                 ″ 
                 2-aminosulfonyl-phenylethyl 
               
               
                   
                 2724 
                 ″ 
                 2-methoxyphenylethyl 
               
               
                   
                 2725 
                 ″ 
                 3-aminophenylethyl 
               
               
                   
                 2726 
                 ″ 
                 3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2727 
                 ″ 
                 3-trifluoromethyl- 
               
               
                   
                   
                   
                 sulfonylamino-phenylethyl 
               
               
                   
                 2728 
                 ″ 
                 3-hydroxy- 
               
               
                   
                   
                   
                 methylenephenylethyl 
               
               
                   
                 2729 
                 ″ 
                 3-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2730 
                 ″ 
                 3-tetrazolephenylethyl 
               
               
                   
                 2731 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2732 
                 ″ 
                 3-aminosulfonyl-phenylethyl 
               
               
                   
                 2733 
                 ″ 
                 3-methoxyphenylethyl 
               
               
                   
                 2734 
                 ″ 
                 4-phenylphenylmethyl 
               
               
                   
                 2735 
                 ″ 
                 4-(2-hydroxy- 
               
               
                   
                   
                   
                 methylenephenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2736 
                 ″ 
                 4-(2-tert- 
               
               
                   
                   
                   
                 butylaminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2737 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenylmethyl 
               
               
                   
                 2738 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenylmethyl 
               
               
                   
                 2739 
                 ″ 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2740 
                 ″ 
                 4-(2-chlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2741 
                 ″ 
                 4-(2-fluorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2742 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2743 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2744 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2745 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2746 
                 ″ 
                 4-(2-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2747 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2748 
                 ″ 
                 4-(2-methoxy-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2749 
                 ″ 
                 4-(2-tmethyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2750 
                 ″ 
                 4-(2-formyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2751 
                 ″ 
                 4-(2-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2752 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2753 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2754 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2755 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2756 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2757 
                 ″ 
                 4-(3-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2758 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2759 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2760 
                 ″ 
                 4-(3-methylsulfonyl-amino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2761 
                 ″ 
                 4-(3-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2762 
                 ″ 
                 4-(3-nitro-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2763 
               
               
                   
                 2764 
                 3-phenylpropyl 
                 H 
               
               
                   
                 2765 
                 ″ 
                 methyl 
               
               
                   
                 2766 
                 ″ 
                 ethyl 
               
               
                   
                 2767 
                 ″ 
                 n-propyl 
               
               
                   
                 2768 
                 ″ 
                 n-butyl 
               
               
                   
                 2769 
                 ″ 
                 n-pentyl 
               
               
                   
                 2770 
                 ″ 
                 n-hexanyl 
               
               
                   
                 2771 
                 ″ 
                 n-heptanyl 
               
               
                   
                 2772 
                 ″ 
                 isopropyl 
               
               
                   
                 2773 
                 ″ 
                 tert-butyl 
               
               
                   
                 2774 
                 ″ 
                 cyclopropyl 
               
               
                   
                 2775 
                 ″ 
                 cyclobutanyl 
               
               
                   
                 2776 
                 ″ 
                 cyclpentanyl 
               
               
                   
                 2777 
                 ″ 
                 cyclohexanyl 
               
               
                   
                 2778 
                 ″ 
                 cycloheptanyl 
               
               
                   
                 2779 
                 ″ 
                 phenyl 
               
               
                   
                 2780 
                 ″ 
                 phenylmethyl 
               
               
                   
                 2781 
                 ″ 
                 3-hydroxyphenyl 
               
               
                   
                 2782 
                 ″ 
                 3-hydroxy-4-methoxyphenyl 
               
               
                   
                 2783 
                 ″ 
                 3-fluorophenyl 
               
               
                   
                 2784 
                 ″ 
                 3-chlorophenyl 
               
               
                   
                 2785 
                 ″ 
                 3-nitrophenyl 
               
               
                   
                 2786 
                 ″ 
                 3-aminophenyl 
               
               
                   
                 2787 
                 ″ 
                 3-methyl-sulfonamidephenyl 
               
               
                   
                 2788 
                 ″ 
                 3-trifluoro- 
               
               
                   
                   
                   
                 methylsulfonamidephenyl 
               
               
                   
                 2789 
                 ″ 
                 3-Ac—NHphenyl 
               
               
                   
                 2790 
                 ″ 
                 3-Boc—NHphenyl 
               
               
                   
                 2791 
                 ″ 
                 3-Cbz—NHphenyl 
               
               
                   
                 2792 
                 ″ 
                 3-aminomethylenephenyl 
               
               
                   
                 2793 
                 ″ 
                 3-aminoethylenephenyl 
               
               
                   
                 2794 
                 ″ 
                 3-cyanophenyl 
               
               
                   
                 2795 
                 ″ 
                 3-cyanomethylphenyl 
               
               
                   
                 2796 
                 ″ 
                 3-hydroxy-methylenephenyl 
               
               
                   
                 2797 
                 ″ 
                 3-carboxylphenyl 
               
               
                   
                 2798 
                 ″ 
                 3-mercaptophenyl 
               
               
                   
                 2799 
                 ″ 
                 3-methoxyphenyl 
               
               
                   
                 2800 
                 ″ 
                 3,4-methylene-dioxophenyl 
               
               
                   
                 2801 
                 ″ 
                 3-tetrazolephenyl 
               
               
                   
                 2802 
                 ″ 
                 3-aminosulfonylphenyl 
               
               
                   
                 2803 
                 ″ 
                 3-methylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2804 
                 ″ 
                 3-ethylamino-sulfonylphenyl 
               
               
                   
                 2805 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenyl 
               
               
                   
                 2806 
                 ″ 
                 3-methylsulfonylphenyl 
               
               
                   
                 2807 
                 ″ 
                 4-methoxyphenyl 
               
               
                   
                 2808 
                 ″ 
                 4-phenylphenyl 
               
               
                   
                 2809 
                 ″ 
                 4-(2-hydroxy- 
               
               
                   
                   
                   
                 methylenephenyl)-phenyl 
               
               
                   
                 2810 
                 ″ 
                 4-(2-tert-butylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2811 
                 ″ 
                 4-(2-methylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2812 
                 ″ 
                 4-(2-ethylamino- 
               
               
                   
                   
                   
                 sufonylphenyl)-phenyl 
               
               
                   
                 2813 
                 ″ 
                 4-(2-aminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2814 
                 ″ 
                 4-(2-chlorophenyl)-phenyl 
               
               
                   
                 2815 
                 ″ 
                 4-(2-fluorophenyl)-phenyl 
               
               
                   
                 2816 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2817 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2818 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2819 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2820 
                 ″ 
                 4-(2-methylphenyl)-phenyl 
               
               
                   
                 2821 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2822 
                 ″ 
                 4-(2-methoxy-phenyl)-phenyl 
               
               
                   
                 2823 
                 ″ 
                 4-(2-tmethyl-phenyl)-phenyl 
               
               
                   
                 2824 
                 ″ 
                 4-(2-formyl-phenyl)-phenyl 
               
               
                   
                 2825 
                 ″ 
                 4-(2-amino-phenyl)-phenyl 
               
               
                   
                 2826 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2827 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2828 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2829 
                 ″ 
                 4-(2-methylsulfonyl-amino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2830 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2831 
                 ″ 
                 4-(3-methylphenyl)-phenyl 
               
               
                   
                 2832 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenyl 
               
               
                   
                 2833 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenyl 
               
               
                   
                 2834 
                 ″ 
                 4-(3-methylsulfonyl-amino- 
               
               
                   
                   
                   
                 phenyl)-phenyl 
               
               
                   
                 2835 
                 ″ 
                 4-(3-amino-phenyl)-phenyl 
               
               
                   
                 2836 
                 ″ 
                 4-(3-nitro-phenyl)-phenyl 
               
               
                   
                 2837 
                 ″ 
                 2-pyridyl 
               
               
                   
                 2838 
                 ″ 
                 3-pyridyl 
               
               
                   
                 2839 
                 ″ 
                 4-pyridyl 
               
               
                   
                 2840 
                 ″ 
                 3-amino-4-pyridyl 
               
               
                   
                 2841 
                 ″ 
                 3-hydroxy-4-pyridyl 
               
               
                   
                 2842 
                 ″ 
                 3-imidazole 
               
               
                   
                 2843 
                 ″ 
                 2-nitro-3-imidazole 
               
               
                   
                 2844 
                 ″ 
                 5-thiazole 
               
               
                   
                 2845 
                 ″ 
                 5-oxazole 
               
               
                   
                 2846 
                 ″ 
                 4-pyazole 
               
               
                   
                 2847 
                 ″ 
                 phenylethyl 
               
               
                   
                 2848 
                 ″ 
                 2-aminophenylethyl 
               
               
                   
                 2849 
                 ″ 
                 2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2850 
                 ″ 
                 2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2851 
                 ″ 
                 2-hydroxymethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2852 
                 ″ 
                 2-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2853 
                 ″ 
                 2-tetrazolephenylethyl 
               
               
                   
                 2854 
                 ″ 
                 2-tert-butylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2855 
                 ″ 
                 2-aminosulfonyl-phenylethyl 
               
               
                   
                 2856 
                 ″ 
                 2-methoxyphenyl 
               
               
                   
                 2857 
                 ″ 
                 3-aminophenylethyl 
               
               
                   
                 2858 
                 ″ 
                 3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2859 
                 ″ 
                 3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonylamino- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2860 
                 ″ 
                 3-hydroxymethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2861 
                 ″ 
                 3-aminomethylene- 
               
               
                   
                   
                   
                 phenylethyl 
               
               
                   
                 2862 
                 ″ 
                 3-tetrazolephenylethyl 
               
               
                   
                 2863 
                 ″ 
                 3-tertbutylamino- 
               
               
                   
                   
                   
                 sulfonylphenylethyl 
               
               
                   
                 2864 
                 ″ 
                 3-aminosulfonyl-phenylethyl 
               
               
                   
                 2865 
                 ″ 
                 3-methoxyphenylethyl 
               
               
                   
                 2866 
                 ″ 
                 4-phenylphenylmethyl 
               
               
                   
                 2867 
                 ″ 
                 4-(2-hydroxymethylene- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2868 
                 ″ 
                 4-(2-tert- 
               
               
                   
                   
                   
                 butylaminosufonyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2869 
                 ″ 
                 4-(2-methylaminosufonyl- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2870 
                 ″ 
                 4-(2-ethylaminosufonyl- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2871 
                 ″ 
                 4-(2-aminosufonylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2872 
                 ″ 
                 4-(2-chlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2873 
                 ″ 
                 4-(2-fluorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2874 
                 ″ 
                 4-(2,4-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2875 
                 ″ 
                 4-(2,6-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2876 
                 ″ 
                 4-(3,5-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2877 
                 ″ 
                 4-(2,3-dichlorophenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2878 
                 ″ 
                 4-(2-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2879 
                 ″ 
                 4-(2-tetrazole-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2880 
                 ″ 
                 4-(2-methoxy-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2881 
                 ″ 
                 4-(2-tmethyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2882 
                 ″ 
                 4-(2-formyl-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2883 
                 ″ 
                 4-(2-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2884 
                 ″ 
                 4-(2-methylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2885 
                 ″ 
                 4-(2-ethylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2886 
                 ″ 
                 4-(2-propylamino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2887 
                 ″ 
                 4-(2-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2888 
                 ″ 
                 4-(2- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2889 
                 ″ 
                 4-(3-methylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2890 
                 ″ 
                 4-(3-isopropylphenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2891 
                 ″ 
                 4-(3- 
               
               
                   
                   
                   
                 trifluoromethylsulfonyl- 
               
               
                   
                   
                   
                 amino-phenyl)-phenylmethyl 
               
               
                   
                 2892 
                 ″ 
                 4-(3-methylsulfonylamino- 
               
               
                   
                   
                   
                 phenyl)-phenylmethyl 
               
               
                   
                 2893 
                 ″ 
                 4-(3-amino-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl 
               
               
                   
                 2894 
                 ″ 
                 4-(3-nitro-phenyl)- 
               
               
                   
                   
                   
                 phenylmethyl