Abstract:
Methods of reducing the adherence of lenses to hydrophobic packing materials using compounds of Formula I are disclosed herein, where R 1 -R 12 , a, b, z, x, q, m, and n are defined herein.

Description:
RELATED APPLICATIONS  
       [0001]    This patent application claims priority from a U.S. patent application Ser. No. 09/731,553, which was filed on Dec. 7, 2000. 
     
    
     
       BACKGROUND  
         [0002]    Contact lenses have been used commercially to improve vision since the 1950s. The first contact lenses were made of hard materials. Although these lenses are currently used, they are not suitable for all patients due to their poor initial comfort. Later developments in the field gave rise to soft contact lenses, based upon hydrogels, which are extremely popular today. These lenses have higher oxygen permeabilities and such are often more comfortable to wear than contact lenses made of hard materials. However, these new lenses are not without problems.  
           [0003]    Contact lenses with high oxygen permeabilites are typically made of hydrophobic materials. The packaging for contact lenses are also made of hydrophobic materials. When one hydrophobic surface comes in contact with another, the surfaces stick to each other. The sticking of a contact lens to its packaging creates many problems. First the packaging is thicker and more rigid than the soft lenses contained therein. If a lens sticks to the packaging, when the user tries to remove the lens, the lens often tears and must be discarded. One solution to this problem is to place a hydrophilic additive such as a surfactant, into the lens packaging solution. However many surfactants that have been used to solve this problem do not prevent the sticking of contact lenses to their packaging. In addition, some surfactants do not completely dissolve in lens packaging solutions and have unfavorable interactions with the lens when they are stored over a period of time, Therefore there is a need for methods of inhibiting the adherence of contact lenses to their packaging. It is this need that is met by the following invention.  
         DETAILED DESCRIPTION OF THE INVENTION  
         [0004]    This invention includes a method of inhibiting the adherence of soft lenses to hydrophobic packaging materials comprising, consisting essentially of, or consisting of storing the soft lenses in a packing solution comprising an effective amount of composition of Formula I  
                         
 
           [0005]    wherein  
           [0006]    R 1  is C 1-6  alkyl;,  
           [0007]    R 2  is —CH 2 OH, —CH 2 OR 3 , —CH 2 OC(O)R 4    
           [0008]    wherein R 3  is C 1-50 alkyl, or C 1-51 alkylene having at least one double bond, R 4  is hydrogen or C 1-12 alkyl;  
           [0009]    R 5  is —OH, or —[(O—(CHR 7 ) a ) n —OR 6 ] 
           [0010]    wherein R 6  is hydrogen C 1-50 alkyl, or C 1-51 alkylene having at least one double bond, R 7  is hydrogen or C 1-12 alkyl;  
           [0011]    R 8  is —OH or —[(O—(CHR 10 ) b ) m —OR 9 ] 
           [0012]    wherein R 9  is hydrogen, C 1-50 alkyl, or C 1-51 alkylene having at least one double bond R 10  is hydrogen or C 1-12 alkyl;  
           [0013]    R 11  is —OH or —OC(O)R 12    
           [0014]    wherein R 12  is C 1-50 alkyl or C 1-51 alkylene having at least one double bond;  
           [0015]    a is 2-4;  
           [0016]    b is 2-4;  
           [0017]    x is 0-3;  
           [0018]    q is 0-3;  
           [0019]    z is 0-3  
           [0020]    wherein the sum of x+q+z=3  
           [0021]    m is an integer, from 1 to 200;  
           [0022]    n is an integer from 1 to 200 wherein the sum of m+n=2 to 400  
           [0023]    provided that if q is 3 R 6  is not ethyl;  
           [0024]    provided that if z is 3 R 9  is not ethyl.  
           [0025]    With respect to Formula I, all substituents are selected independent of one another. The term alkyl refers to straight or branched alkyl chains. Alkylene refers to a carbon radical having at least one point of unsaturation. The preferred values for the substituents are as follows:  
           [0026]    R 1  is methyl, ethyl or propyl,  
           [0027]    R 2  is —CH 2 OC(O)R 4 ,  
           [0028]    R 3  is C 10-18 alkyl,  
           [0029]    R 4  is C 8-30 alkyl, or C 10-30 alkylene having at least one double bond,  
           [0030]    R 5  is —[(O—(CHR 7 ) a ) n —OR 6 ],  
           [0031]    R 6  is C 8-30 alkyl, or C 10-30 alkylene having at least one double bond,  
           [0032]    R 7  is hydrogen,  
           [0033]    R 8  is —[(O—(CHR 10 ) b ) m —OR 9 ] 
           [0034]    R 9  is C 8-30 alkyl, or C 10-30 alkylene having at least one double bond,  
           [0035]    R 10  is hydrogen,  
           [0036]    R 11  is OC(O)R 12 ,  
           [0037]    R 12  is C 8-30 alkyl or C 10-30 alkylene having at least one double bond,  
           [0038]    a is 2-3,  
           [0039]    b is 2-3,  
           [0040]    x is 1,  
           [0041]    q is 1,  
           [0042]    z is 1,  
           [0043]    m is 60-140  
           [0044]    n is 80-120,  
           [0045]    wherein the preferred sum of m+n is about 100-200.  
           [0046]    Examples of suitable compositions of Formula I include but are not limited to CAS No.119831-19-5, 223717-75-7, and 116057-48-8.  
           [0047]    The most particularly preferred composition of Formula I is poly(oxy-1,2-ethandiyl) α-hydro-ω-hydroxy-, ether with methyl D-glucopyranoside 2,6-di-9Z-9-octadecenaoate, commercially known as Glucamate DOE 120.  
           [0048]    The compositions of Formula I may be combined with any known active or carrier components useful for lens packing solutions. Suitable additional ingredients include but are not limited to antibacterial agents, anti-dryness agents, such a polyvinyl alcohol, polyvinyl pyrrolidone, and dextran, tonicity agents, and combinations thereof.  
           [0049]    The packing solutions of the invention may be any water-based solution that is used for the storage of contact lenses. Typical solutions include, without limitation, saline solutions, other buffered solutions, and deionized water. The preferred aqueous solution is saline solution containing salts including, without limitation, sodium chloride, sodium borate, sodium phosphate, sodium hydrogenphosphate, sodium dihydrogenphosphate, or the corresponding potassium salts of the same. These ingredients are generally combined to form buffered solutions that include an acid and its conjugate base, so that addition of acids and bases cause only a relatively small change in pH. The buffered solutions may additionally include 2-(N-morpholino)ethanesulfonic acid (MES), sodium hydroxide, 2,2-bis(hydroxymethyl)-2,2′, 2″-nitrilotriethanol, n-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, citric acid, sodium citrate, sodium carbonate, sodium bicarbonate, acetic acid, sodium acetate, ethylenediamine tetraacetic acid and the like and combinations thereof. Preferably, the solution is a borate buffered or phosphate buffered saline solution.  
           [0050]    As used herein “soft lenses” refers to an ophthalmic devices that resides in or on the eye. These devices can provide optical correction or may be cosmetic. The term lens includes but is not limited to soft contact lenses, intraocular lenses, overlay lenses, ocular inserts, and optical inserts. The preferred lenses of the invention are soft contact lenses are made from silicone elastomers or hydrogels, which include but are not limited to silicone hydrogels, and fluorohydrogels. Soft contact lens formulations are disclosed in U.S. Pat. No. 5,710,302, WO 9421698, EP 406161, JP 2000016905, U.S. Pat. No. 5,998,498, U.S. patent application Ser. No. 09/532,943, U.S. Pat. No. 6,087,415, U.S. Pat. No. 5,760,100, U.S. Pat. No. 5,776, 999, U.S. Pat. No. 5,789,461, U.S. Pat. No. 5,849,811, and U.S. Pat. No. 5,965,631. The foregoing references are hereby incorporated by reference in their entirety. The particularly preferred lenses of the inventions are etafilcon A, genfilcon A, lenefilcon A, and polymacon. The most preferred lenses include but are not limited to silicone hydrogels such as acquafilcon A, balafilcon A, lotrafilcon A, and silicone hydrogels as prepared in U.S. Pat. No.5,998,498, U.S. patent application Ser. No. 09/532,943, a continuation-in-part of U.S. patent application Ser. No. 09/532,943, filed on Aug. 30, 2000, U.S. Pat. No. 6,087,415, U.S. Pat. No. 5,760,100, U.S. Pat. No. 5,776, 999, U.S. Pat. No. 5,789,461, U.S. Pat. No. 5,849,811, and U.S. Pat. No. 5,965,631. These patents as well as all other patents disclosed in this application are hereby incorporated by reference in their entirety.  
           [0051]    “Hydrophobic packaging materials,” refer to substances that are used to prepare containers for manufacturing lenses prior to their use by an end user. These packaging materials are discarded by the user after the soft contact lens is placed in the eye of a user. Examples of hydrophobic packaging materials include but are not limited to polypropylene, polyethylene, nylons, olefin co-polymers, acrylics, rubbers, urethanes, polycarbonates, or fluorocarbons. The preferred materials are metallocenes polymers and co-polymers made of polypropylene, polyethylene, having a melt flow range of about 15 g/10 minutes to about 44 g/10 minutes as determined by ASTM D-1238. Containers made from hydrophobic packaging material may be in many forms. These containers may store a single lenses or many lenses. An example of a single lens storage unit is a blister package, such as the packages disclosed in the following publications, U.S. Pat. Nos. D435,966 S; 4,691,820; 5,467,868; 5,704,468; 5,823,327; 6,050,398, which are hereby incorporated by reference in their entirety. Examples of multiple lens storage units include the hydrophobic molds that are used to produce contact lenses as shown in U.S. Pat. No. 4,640,489 which is hereby incorporated in reference in its entirety.  
           [0052]    The term “effective amount” refers to the percentage of weight of compositions of Formula I that will inhibit the adherence of lenses to hydrophobic packaging. The effective amount is about 0.01 weight percent to about 2.0 weight percent, preferably about 0.05 weight percent to about 1.50 weight percent, more preferably about 0.05 to about 0.1 weight percent.  
           [0053]    In order to illustrate the invention the following examples are included. These examples do not limit the invention. They are meant only to suggest a method of practicing the invention. Those knowledgeable in contact lenses as well as other specialties may find other methods of practicing the invention. However, those methods are deemed to be within the scope of this invention. 
       
    
    
     EXAMPLES  
       [0054]    The following abbreviations are used in the examples below:  
                                       DMA   N,N-dimethylacrylamide       HEMA   2-hydroxyethyl methacrylate       mPDMS   800-1000 MW monomethacryloxypropyl terminated           polydimethylsiloxane       Norbloc   2-(2′-hydroxy-5-methacrylyloxyethylphenyl)-2H-           benzotriazole       CGI 1850   1:1 (wgt) blend of 1-hydroxycyclohexyl phenyl ketone and           bis(2,6-dimethoxybenzoyl)-2,4-4-trimethylpentyl           phosphine oxide       PVP   poly(N-vinyl pyrrolidone) having a molecular weight of       2,500-40,000   approximately 2,500 to 40,000       Blue HEMA   the reaction product of Reactive Blue 4 and HEMA, as           described in Example 4 of U.S. Pat. No. 5,944,853       IPA   isopropyl alcohol       D3O   3,7-dimethyl-3-octanol       TEGDMA   tetraethyleneglycol dimethacrylate       TRIS   3-methacryloxypropyltris(trimethylsiloxy)silane       Tween 80   CAS number 9005-656       Polyoxide   poly(ethylene)oxide having a molecular       (100,000-5,000,000)   weight of 100,000 to 5,000,000       Tyloxapol   CAS number 25301-02-4       DOE-120   CTFA name: Polyethylene glycol 120 methyl glucose           dioleate       EDTA   ethylenediamine tetraacetic acid       F127   Poloxamer 407 NF, CAS number 106392-12-5       DI   Deionized water       CYST   N,N′-bis(acryloyl)cystamine       Macromer 2   the reaction product of described in the examples of U.S.           pat. app. Ser. No. 10/028,400 filed on Dec. 20, 2001 and           entitled Antimicrobial Contact Lenses and Methods for           Their Production       DPMA   dipropylene glycol methyl ether acetate       N/A   not tested       Big Blue   A mixture of 900 mg blue HEMA, 44.1 g HEMA, 615 mg           CGI 1850 and 150 mL ethylene glycol was stirred until           homogeneous and the system was degassed as           described in example 1. The mixture was transferred to a           large crystallizing dish and covered with a watch glass.           Polymerization of the olefinic moieties was conducted           under visible light for approximately 1 hour (Phillips TL20           W/03T bulbs). Upon quenching of the polymerization           using oxygen, the mixture was poured into 500 mL of           borate- buffered saline solution and stirred for several           hours until the material was transformed into a more rigid           form. The liquids were decanted, and the product was           washed with another 500 mL of borate-buffered saline           solution, the polymer was cut into several smaller pieces,           and stirred in 500 mL of deionized water for more than 1           hour to the point that the product became gel-like and           sparingly soluble in the solvent. The mixture was then           diluted with a small quantity of borate-buffered saline           solution to enable better precipitation of the polymer. The           mixture was filtered and washed in deionized water until           the material did not appear soluble. The suspension was           filtered, dried in a rotary evaporator, cut into smaller           pieces and further dried until it appeared crystalline and           anhydrous. The dark blue polymer was then milled into           fine particles and subjected to more deionized water           washings accompanied by 1 to 2 hours of stirring with           each wash. Washing continued until little or no blue color           was visible in solution and the product was filtered, dried           at reduced pressure, and ground in a blender.           GPC data for each of the polymers were obtained using           both R.I and light scattering detectors. Chromatography           was performed using a mixed bed GPC column           (phenogel 300 mm × 7.8 mm × 5 micron (2) column           (Phenomenex) having a separation range of 100 K to           10,000 K, and 0.5 wt % lithium bromide in           dimethylformamide as the eluent.           Mn = 1.133 × 10 6 ; Mw = 1.222 × 10 6 ; Mz = 1.354 × 10 6 ;           polydispersity (Mw/Mn) = 1.078.                  
 
         [0055]    Lens Preparation  
         [0056]    Lenses A  
         [0057]    Monomer mix is prepared by blending 18.16 weight percent of GTP(Macromer 2), 28.29% mPDMS,14.14% TRIS, 26.27% DMA, 5.05% HEMA, 5.05% PVP (360,000 molecular weight), 2.02% Norbloc, 0.02% Blue HEMA, 1% CGI 1850, in a blend with 79.84 parts of this combination with 20.16 parts D30 diluent and CYST 0.4%. Contact lenses were made by placing this monomer mix into thermoplastic contact lens molds, and irradiating using Philips TL20W/03T fluorescent bulbs at 70° C. for about 15 minutes. The molds were opened and lenses were extracted into DPMA solvent. The lenses were then rinsed in a 100 ppm Tween 80 in DI mixture to insure removal of solvent. The lenses were then equlibrated in deionized water.  
         [0058]    Lenses B  
         [0059]    Monomer mix is prepared by blending 17.98 weight percent of GTP(Macromer 2), 28% mPDMS,14% TRIS, 26% DMA, 5% HEMA, 5% PVP, 2% Norbloc, 1% TEGDMA, 0.02% Blue HEMA,1% CGI 1850, in a blend with 80 parts of this combination with 20 parts D3O diluent and CYST 0.2%. Lenses were made in the same manner as Lenses A with the exception that lenses were extracted in IPA. Lenses were then placed into deionized water for equilibration.  
         [0060]    Lenses C  
         [0061]    Monomer mix is prepared by blending 17.98 weight percent of GTP(Macromer 2), 28% mPDMS, 14% TRIS, 26% DMA, 5% HEMA, 5% PVP, 2% Norbloc, 1% TEGDMA, 0.02% Blue HEMA,1% CGI 1850, in a blend with 80 parts of this combination with 20 parts D3O diluent. Lenses were made in the same manner as Lenses A.  
         [0062]    Lenses D  
         [0063]    Monomer mix is prepared by blending 17.98 weight percent of GTP(Macromer 2), 28% mPDMS,14% TRIS, 26% DMA, 5% HEMA, 5% PVP (360,000 molecular weight), 2% Norbloc, 1% TEGDMA, 0.02% Blue HEMA, 1% CGI 1850, in a blend with 80 parts of this combination with 20 parts D30 diluent. Lenses were made in the same manner as Lenses A, with the exception that the lens molds had a pHEMA(big blue) coating on the surface as per the method disclosed in U.S. patent application Ser. No. 09/921,192 entitled “Method for Correcting Articles by Mold Transfer,” and that they were equilibrated into packing solution.  
         [0064]    Lenses E  
         [0065]    Monomer mix is prepared by blending 18.16 weight percent of GTP(Macromer 2), 28.29% mPDMS,14.14% TRIS, 26.27% DMA, 5.05% HEMA, 5.05% PVP (360,000 molecular weight), 2.02% Norbloc, 0.02% Blue HEMA,1% CGI 1850, in a blend with 79.84 parts of this combination with 20.16 parts D3O diluent and CYST 0.4 Lenses were made in the same manner as Lenses A, with the exception that the lens molds had a pHEMA (big Blue) coating on the surface.  
         [0066]    Lenses F  
         [0067]    Lenses A were placed in a 10% silver nitrate solution for 60 minutes at room temperature for silver treatment. The lenses were then washed 3 times with DI water in 20 minute intervals to remove any excess silver. The lenses were then equilibrated in borate buffered saline.  
         [0068]    Lenses G  
         [0069]    Lenses B were placed in a 10% silver nitrate solution for 60 minutes at room temperature for silver treatment. The lenses were then washed 3 times with DI water in 20 minute intervals to remove any excess silver. The lenses were then equilibrated in borate buffered saline.  
         [0070]    Lenses H  
         [0071]    Lenses E were placed in a 10% silver nitrate solution for 60 minutes at room temperature for silver treatment. The lenses were then washed 3 times with DI water in 20 minute intervals to remove any excess silver. The lenses were then equilibrated in borate buffered saline.  
         [0072]    Solution A  
         [0073]    Solution A was made by adding 0.10 weight % of sodium borate, 0.91 weight % Boric Acid, 0.83% Sodium Chloride, 0.01% EDTA and 98.15 weight % water into a volumetric flask and was mixed at ambient temperature until all solids were dissolved. Solution A has a pH of 7.6 (measured at 20-30° C.), an osmolality of 170 (measured at ca. 25° C.) and a conductivity (m/S/cm) of 0.7 (measured at 20-30° C.)  
         [0074]    Solution B  
         [0075]    A solution was made by adding 0.185 weight % of sodium borate, 0.926 weight % Boric Acid and 98.89 weight % water into a volumetric flask and was mixed at ambient temperature until all solids were dissolved. Solution B has a pH of 7.0-7.6 (measured at 20-30° C.), an osmolality of 420 (measured at ca. 25° C.) and a conductivity (m/S/cm) of 14.5-15.5 (measured at 20-30° C.).  
         [0076]    Solution C  
         [0077]    Pure Vision Packing Solution removed from packaged commercially available Pure Vision Lenses.  
       Example 1  
     Solution A with a Variety of Surfactants  
       [0078]    Lenses were added to individual polypropylene blister packs containing 950 μL of Solution A, and then the blister pack was heat sealed. Lenses were visually evaluated for lens&#39; adhesion to the package, both prior to and after one autoclave cycle of 30 minutes±5 minutes at 121° C.±5° C. and subsequent cooling to room temperature. Different amounts of surfactants were added to Solution A and lenses were evaluated before and after an autoclave cycle to determine the degree of adhesion to a package. Solution B and Solution C (without any added surfactants) were evaluated as well. The data is presented below in Table 1 and Table 2  
                                                                                                                                                                                                                                                                                                                                                                                                                                                     TABLE 1                           Solution A (except as       noted)       Solutions /            Concentration   Autoclaved            (ppm)   Lenses D   Lenses A   Lenses G   Lenses H   Lenses E               No Surfactant   Stick   Stick   Stick   Stick   Stick            PVP (2,500)                50   Stick   Stick   Stick   N/A   Mild Sticking       100   Stick   Stick   Stick   N/A   Stick       250   Stick   Stick   Stick   Stick   Stick            PVP (10,000)                50   Stick   Stick   Stick   N/A   Stick       100   Stick   Stick   Stick   N/A   Stick       250   Stick   Stick   Stick   Stick   Stick       1000   No Sticking   Stick   Stick   N/A   Stick            Polyoxide           (100,000)            50   Stick   Stick   N/A   N/A   Stick       100   Stick   Stick   N/A   N/A   Stick       250   Stick   Mild Sticking   Stick   Stick   Stick            Tween 80                50   Stick   N/A   N/A   N/A   N/A       100   Stick   N/A   N/A   N/A   N/A       250   Stick   Mild Sticking   Stick   Mild Sticking   Stick            PVP (25,000)                1000   Stick   Stick   Stick   Stick   Stick            PVP (40,000)                1000   Stick   Stick   Stick   Stick   Stick            F127                1000   No Sticking   No Sticking   No Sticking   No Sticking   No Sticking            Solution B.   Stick   Stick   Stick   Stick   Stick       Solution C   Stick   N/A   N/A   N/A   N/A            Tyloxapol                10,000   Stick   N/A   N/A   N/A   N/A            Polyoxide           (300,000)            10,000   Stick   N/A   N/A   N/A   N/A            Polyoxide           (5,000,000)            1000   Stick   N/A   N/A   N/A   N/A                  
 
         [0079]    [0079]                                                                                                                                                                                                                                                                                                                                                                                                                           TABLE 2                           Solution A (except as       noted)       Solutions/            Concentration   Non-Autoclaved            (ppm)   Lenses D   Lenses A   Lenses G   Lenses H   Lenses E               No Surfactant   Stick   Stick   Stick   Stick   Stick            PVP (2,500)                50   Stick   Stick   Stick   N/A   Mild Sticking       100   Stick   Stick   Stick   N/A   Stick       250   Mild Sticking   Mild Sticking   Mild Sticking   Stick   Mild Sticking            PVP (10,000)                50   Stick   Stick   Stick   N/A   Stick       100   Stick   Stick   Mild Sticking   N/A   Mild Sticking       250   Mild Sticking   Mild Sticking   Mild Sticking   Mild Stick   Stick       1000   No Sticking   Stick   Stick   N/A   Stick            Polyoxide           (100,000)            50   Stick   Stick   N/A   N/A   Mild Sticking       100   Stick   Stick   N/A   N/A   Stick       250   Mild Sticking   Mild Sticking   Mild Sticking   No Sticking   Stick            Tween 80                50   Mild Sticking   N/A   N/A   N/A   N/A       100   No Sticking   N/A   N/A   N/A   N/A       250   Mild Sticking   No Sticking   No Sticking   N/A   Mild Sticking            PVP (25,000)                1000   No Sticking   Stick   No Sticking   N/A   Stick            PVP (40,000)                1000   Stick   Stick   No Sticking   N/A   Stick            F127                1000   No Sticking   No Sticking   No Sticking   No Sticking   No Sticking       Solution B.   Stick   Stick   Stick   Stick   Stick       Solution C   Stick   N/A   N/A   N/A   N/A            Tyloxapol                1%   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (300,000)            1%   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (5,000,000)            1000 ppm   No Sticking   N/A   N/A   N/A   N/A                    
       Example 2  
     Solution A with a Variety of Surfactants  
       [0080]    Lenses were added to individual polypropylene blister packs and subsequently 950 μL of Solution A, was added to the blister packs. The filled packs were heat sealed. Lenses were visually evaluated for lens&#39; adhesion to the package, both prior to and after one autoclave cycle of 30 minutes±5 minutes at 121° C.±5° C. and subsequent cooling to room temperature. Different amounts of surfactants were added to Solution A and lenses were evaluated before and after an autoclave cycle to determine the degree of adhesion to a package. Solution B and Solution C (without any added surfactants) were evaluated as well. The data is presented below in Table 3 and Table 4.  
                                                                                                                                                                                                                                                                                                                                                                                                                           TABLE 3                           Lens First       Solutions /            Concentration   Autoclaved            (ppm)   Lenses D   Lenses A   Lenses G   Lenses H   Lenses E               No Surfactant   Stick   Stick   Stick   Stick   Stick            PVP (2,500)                50   Stick   Stick   Stick   N/A   Stick       100   Stick   Stick   Stick   N/A   Stick       250   Stick   Stick   Stick   Stick   Stick            PVP (10,000)                50   Stick   Stick   Stick   N/A   Stick       100   Stick   Stick   Stick   N/A   Stick       250   Stick   Stick   Stick   Stick   Stick       1000   N/A   N/A   Stick   Stick   Stick            Polyoxide           (100,000)            50   Stick   Stick   N/A   N/A   Stick       100   Stick   Stick   N/A   N/A   Stick       250   Stick   Mild Sticking   Stick   Stick   Stick            Tween 80                50   Stick   N/A   N/A   N/A   N/A       100   Stick   N/A   N/A   N/A   N/A       250   Stick   Mild Sticking   Mild Sticking   No Sticking   Stick            PVP (25,000)                1000   Stick   Stick   Stick   N/A   N/A            PVP (40,000)                1000   Stick   Stick   No Sticking   Stick   N/A            F127                1000   N/A   N/A   N/A   N/A   N/A       Solution B   Stick   Stick   Stick   Stick   Stick       Solution C   N/A   N/A   N/A   N/A   N/A            Tyloxapol                10,000   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (300,000)            10,000   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (5,000,000)            1000   No Sticking   N/A   N/A   N/A   N/A                  
 
         [0081]    [0081]                                                                                                                                                                                                                                                                                                                                                                                                                           TABLE 4                           Lens First (A)       Solutions /            Concentration   Non-Autoclaved            (ppm)   Lenses D   Lenses A   Lenses H   Lenses I   Lenses E               No Surfactant   Stick   Stick   Stick   Stick   Stick            PVP (2,500)                50   Stick   Stick   Stick   N/A   Mild Sticking       100   Stick   Stick   Stick   N/A   Stick       250   Mild Sticking   Mild Sticking   Stick   Stick   Stick            PVP (10,000)                50   Stick   Stick   Stick   N/A   Stick       100   Stick   Stick   Stick   N/A   Stick       250   Mild Sticking   Mild Sticking   Stick   Stick   Stick       1000   Mild Sticking   Stick   No Sticking   N/A   Stick            Polyoxide           (100,000)            50   Stick   Stick   N/A   N/A   Stick       100   Stick   Stick   N/A   N/A   Stick       250   Mild Sticking   Mild Sticking   No Sticking   Stick   Mild Sticking            Tween 80                50   Mild Sticking   No Sticking   N/A   N/A   N/A       100   Stick   N/A   N/A   N/A   N/A       250   Mild Sticking   N/A   No Sticking   N/A   No Sticking            PVP (25,000)                1000   Stick   Stick   No Sticking   N/A   Mild Sticking            PVP (40,000)                1000   Stick   Stick   Mild Sticking   N/A   Mild Sticking            F127                1000   N/A   N/A   N/A   N/A   N/A       Solution B   Stick   Stick   Stick   Stick   Stick       Solution C   N/A   N/A   N/A   N/A   N/A            Tyloxapol                1%   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (300,000)            1%   No Sticking   N/A   N/A   N/A   N/A            Polyoxide           (5,000,000)            1000 ppm   No Sticking   N/A   N/A   N/A   N/A                    
       Example 3  
     Solution A with a Variety of Surfactants  
       [0082]    Lenses were added to individual polypropylene blister packs containing 1.0 mL of Solution A, was added to the blister packs. The filled packs were heat sealed. Lenses were visually evaluated for lens&#39; adhesion to the package, both prior to and after one autoclave cycle of 30 minutes±5 minutes at 121° C.±5° C. and subsequent cooling to room temperature. Different amounts of surfactants were added to Solution A and lenses were evaluated before and after an autoclave cycle to determine the degree of adhesion to a package. The results were the same before and after autoclave and the data is presented below in Table 5.  
                                       TABLE 5                           Solution/                               concentration   Total #       Lenses   ppm   lenses   1   2   3   4                   Lenses C   No Surfactant   6               6       Lenses C   PVP 360,000/1000   6       6       Lenses C   PEO 5,000,000/1000   6       6       Lenses C   DOE-120/1000   6   6       Lenses D   No surfactant   5               5       Lenses D   DOE-120/500   5   5       Lenses D   DOE-120/250   5   3   2       Lenses D   DOE-120/100   5   3   2