Abstract:
An improved prefilled, telescoping ampoule device having a simplified construction allows for passage of fluid from one component to the other without leakage. The telescoping ampoule device can be manufactured and assembled in an efficient manner and provides for adaptation to various application purposes without a change of basic design.

Description:
BACKGROUND OF THE INVENTION 
     Safe and hygienic application of predetermined doses of medical fluids such as eye drops and the like rely on an adequate storage of those doses in an ampoule device without danger of introducing contaminants. Substantially, the same holds true for cosmetic samples in form of predetermined amounts of a cosmetic fluid prefilled in an ampoule device for a single use by test persons without danger of contamination through use of other persons. 
     Usually, those non-refillable ampoule devices should have a construction being as simple as possible, cheap in production and, furthermore, offering, despite of their simple construction, a reliable performance and easy manipulability for the patient or customer, respectively. 
     These features should also be maintained as far as possible for prefilled ampoule devices in which two or more fluids have to be stored in such a way that it is possible to apply the mixed fluid components. 
     For the above purposes, there have been developed a plurality of ampoule or vial devices with one or a plurality of chambers offering the possibility of applying a desired amount of fluid by means of a brush or other tool to be inserted into the chamber or chambers, respectively, or alternatively, by means of a syringe or nozzle-like mechanism combined with the vial or ampoule device. (U.S. Pat. No. 5,636,931, Patent Abstracts of Japan vol. 096, no. 011, 29. November 1996 &amp; JP 08 187121 A, EP 0577200A1, U.S. Pat. No. 3,870,147, DE 9202654, U.S. Pat. No. 4,927,282, U.S. Pat. No. 4,793,476, EP 0 295 265 B1, WO 9208506, U.S. Pat. No. 5,330,048, EP 0090413 A1, U.S. Pat. No. 2,478,844, CH 367284, DE 4406503, U.S. Pat. No. 4,391,590). 
     Before applying the fluid or fluid mixture, the user must operate a mechanism for providing access to the fluid or fluid mixture. A plurality of solutions require rupturing a closure member or a weakened breaking point. Other solutions merely require a telescopic action between at least two device members in order to transfer the application fluid into an accessible chamber. Such a solution is e.g. disclosed in U.S. Pat. No. 4,741,737 and U.S. Pat. No. 4,809,711 of Meyer et al describing a prefilled ampoule-syringe. 
     Furthermore, the inventor of the present application disclosed in his earlier WO 98/63994 (U.S. Pat. No. 6,227,736 filed on Oct. 20, 1998), assigned to the same assignee as the present application, a prefilled ampoule device with a brush-like application tool, having an outer sleeve and an inner sleeve being subjected to a telescoping movement. The inner sleeve is liquid-tightly and slidingly provided in the outer sleeve, and it has transverse openings near its bottom. Above the openings, the inner sleeve comprises an annular sealing groove which, in the closed storage position of the ampoule device, engages an annular sealing lip protruding from the inner wall of the outer sleeve. In addition to the sealing means, locking means are provided for locking the inner sleeve within the outer sleeve. 
     Though a plurality of devices have already been developed especially for medical purposes there is still a need for a simplified construction which, nevertheless, is reliable and easy to manipulate. 
     SUMMARY OF THE INVENTION 
     The main object of the present invention is to provide an improved prefilled ampoule device which has a simplified construction, can be manufactured and assembled in an easier manner and at less expense, and offers the possibilty of adapting it to various application purposes without changing the basic design. 
     This main object is achieved in a prefilled telescoping ampoule device comprising: 
     a receptacle made of elastomeric material including a hollow cylindrical body having a closed lower end, an open upper end, and a peripheral sealing lip projecting radially inwardly from the inner wall of the cylindrical body between the closed lower end and the open upper end thereof; 
     an insertion member including a cylindrical portion having a closed lower end, an open upper end, a transverse opening radially extending from the outer wall into the interior of the cylindrical portion, and a longitudinal passage axially extending within the interior of the cylindrical portion from the transverse opening to the open upper end of the cylindrical portion; 
     the cylindrical portion of the insertion member with its closed lower end ahead being inserted into the open upper end of the hollow cylindrical body and being arranged therein for coaxially telescoping movement of the receptacle and the insertion member towards one another from a closed storage position to an open release position; 
     wherein, in the closed storage position, the closed lower end of the cylindrical portion of the insertion member is spaced a distance from the lower end of the hollow cylindrical body so as to define therein a cylindrical chamber containing a substance, and the peripheral sealing lip of the cylindrical body is sealingly pressed into circumferential contact with the outer wall of the cylindrical portion of the insertion member at a location above the closed lower end of the cylindrical body and below the transverse opening so as to prevent release of substance from the chamber into the transverse opening and to frictionally hold the insertion member in place within the receptacle during transportation and storage, and 
     wherein in the open release position, after telescoping movement the lower end of the cylindrical portion of the insertion member is positioned at or close to the lower end of the cylindrical body of the receptacle and the transverse opening of the cylindrical portion of the insertion member is located below the sealing lip of the cylindrical body resulting in a reduced volume of the chamber and a release of substance from the chamber into the transverse opening and the longitudinal passage of the cylindrical portion of the insertion member, and the sealing lip of the cylindrical body is sealingly pressed into circumferential contact with the outer wall the cylindrical portion of the insertion member at a location above the transverse opening so as to prevent escape of substance from the chamber to the upper open end of the hollow cylindrical body of the receptacle. 
     A main advantage of the present invention is that it achieves a reliable performance by providing a single sealing lip without a corresponding sealing groove and any additional locking means. 
     The prefilled substance is accessible by dipping an applicator tool such as a brush into the insertion member in the open release position of the device or, alternatively, is ejected from the open end of insertion member during the telescoping movement from the closed storage position to the open release position. 
     In adapting the device of the present invention to the first alternative the longitudinal passage of the cylindrical portion of the insertion member has in relation to the outer diameter of the cylindrical portion a large inner diameter so as to define a cylindrical chamber within the cylindrical portion of the insertion member. 
     In adapting the device to the second alternative the insertion member includes a coaxially extending tubular portion integrally formed on top of the cylindrical portion having a smaller outer diameter than the cylindrical portion and ending on its upper end in an open tip, and the longitudinal passage is provided in form of a narrow conduit extending from the cylindrical body into the tubular portion up to the open tip thereof. 
     Furthermore, due to the simple construction, it is possible to provide more than one insertion member such that after telescoping movement of all insertion members and the outermost receptacle two or even more prefilled substances are mixed with each other. Hence, it is possible to mix several prefilled liquid substances or even a prefilled solid substance with liquid substances. 
     Whenever a second or even a third substance is provided within a first or even a second insertion member an additional sealing lip is provided in the receptacle such that, in the closed storage position, this additional sealing lip is provided above the transverse opening of the only or first insertion member. This additional sealing lip is provided in addition to the sealing lip of the receptacle provided, in the closed storage position, below the transverse opening of the first insertion member and above the closed lower end of the cylindrical portion of the first insertion member. Likewise, whenever a third substance is provided in a second insertion member, two sealing lips are provided on the inner wall of the first insertion member such that, in the closed storage position, one sealing lip is provided below the transverse opening of the second insertion member and above the closed lower end of the cylindrical portion of the second insertion member and an additional sealing lip is provided above the transverse opening of the second insertion member. In this way, it is possible to prevent escape of a first, second or third substance via the transverse openings and through any radial space between receptacle and first insertion member and between first insertion member and second insertion member and so on. 
     A further aspect of the present invention is the provision of a separate manipulating member including a tubular front portion enclosing an outlet passage and a rear portion integrally formed therewith and enclosing at least one axially extending inlet passage for receiving the tubular portion on top of the cylindrical portion of an insertion member and being in fluid communication with the outlet passage, and the manipulating member including a shoulder transversely extending outwards with respect to the at least one axially extending inlet passage for manually performing telescoping movement between the receptacle and the insertion member. 
     Another further aspect of the invention is the provision of another separate manipulating member designed for receiving the receptacle and insertion member in the closed storage position and having a retractable slider for manually performing telescoping movement between the receptacle and the insertion member. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS 
     FIG. 1 is a longitudinal sectional view of a first preferred embodiment of a prefilled telescoping ampoule device of the present invention showing the device in its closed storage position; 
     FIG. 2 is a similar view showing the device of FIG. 1 in its open release position; 
     FIG. 3 is a longitudinal sectional view of a second preferred embodiment of a prefilled telescoping ampoule device of the present invention having a cap and storing two separate fluid components, showing the device in its closed storage position; 
     FIG. 4 is a similar view showing the device of FIG. 3 in its open release position; 
     FIG. 5 is a longitudinal sectional view of a modification of the second embodiment of a prefilled telescoping ampoule device of the present invention having a cap holding an applicator tool and showing the device in its open release position; 
     FIG. 6 is a longitudinal sectional view of a prefilled multi-chamber telescoping ampoule device closed by a plug according to a modification of the first embodiment of the present invention, showing the device in its closed storage position; 
     FIG. 7 is a sectional view of a third preferred embodiment of a prefilled telescoping ampoule device of the present invention showing the device in its closed storage position; 
     FIG. 8 is a similar view showing the device of FIG. 7 in its open release position together with an applicator tool; 
     FIG. 9 is a perspective view of the insertion member of the device of FIG. 7 and 8; 
     FIG. 10 is a longitudinal sectional view of a fourth preferred embodiment of a prefilled telescoping ampoule device of the present invention with a nozzle-like insertion member having a narrow longitudinal passage, showing the device in its closed storage position; 
     FIG. 11 is a similar view showing a modification of the device of FIG. 10 in its open release position; 
     FIG. 12 is a longitudinal sectional view of a modification of the fourth embodiment of the present invention with an insertion member having a narrow longitudinal passage, a slider provided on the outer cylindrical wall of the insertion member and a particular applicator portion provided at the upper end of the insertion member, showing the device in its closed storage position; 
     FIG. 13 is a longitudinal sectional view showing a modification of the applicator portion provided at the upper end of the insertion member of the device shown in FIG. 12; 
     FIG. 14 is a longitudinal sectional view of a further development of the fourth embodiment of the device of FIG. 10 including a separate manipulating member for receiving the tubular portion of the insertion member; 
     FIG. 15 is a longitudinal sectional view of a another further development of the fourth embodiment of the device of FIG. 10 including a separate manipulating member having a recess for receiving the receptacle and insertion member; 
     FIG. 16 is a longitudinal sectional view showing a further feature of the embodiments of the present invention; 
     FIG. 17 is a perspective view of a further development of the first embodiment of FIG. 1 and 2 and a perspective view of a plurality of the further developed devices connected together for allowing easier manipulation; and 
     FIG. 18 is a longitudinal sectional view of a modification of the further development shown in FIG.  14 . 
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     FIGS. 1 and 2 show a first preferred embodiment of a prefilled telescoping ampoule device of the present invention comprising a receptacle  1 , an insertion member  3 , and a liquid substance  6 . 
     The receptacle  1  consists of a hollow cylindrical body having a closed lower end la, an open upper end  1   b  axially spaced therefrom, and an annular peripheral sealing lip  2  projecting radially inwardly from the inner wall of the cylindrical body between the closed lower end  1   a  and the open upper end  1   b . The insertion member  3  includes a cylindrical portion having a closed lower end  3   a , an open upper end  3   b  axially spaced therefrom, a transverse opening  4  radially extending, at or near the closed lower end  3   a , from the outer wall of the insertion member  3  into the interior of the cylindrical portion, and a longitudinal passage  5  axially extending within the interior of the cylindrical portion from the transverse opening  4  to the open upper end  3   b  of the cylindrical portion. Accordingly, the longitudinal passage  5  communicates with the transverse opening  4  and, as it can be seen from FIG. 1 and 2, has, in this particular embodiment, a wide lumen (inner diameter) with respect to the outer diameter of the cylindrical portion. 
     The cylindrical portion of the insertion member  3 , after being inserted with its closed lower end  3   a  ahead into the open upper end  1   b  of the hollow cylindrical body of receptacle  1 , is arranged in the hollow cylindrical body for coaxially telescoping movement of the receptacle  1  and the insertion member  3  towards one another from a closed storage position shown in FIG. 1 to an open release position shown in FIG.  2 . In the closed storage position, the closed lower end  3   a  of the cylindrical portion of the insertion member  3  is spaced a distance from the lower end  1   a  of the hollow cylindrical body so as to define therein a cylindrical chamber  7  containing the substance  6 . In the closed storage position, the peripheral sealing lip  2  of the cylindrical body of the receptacle  1  is sealingly pressed into circumferential contact with the outer wall of the cylindrical portion of the insertion member  3  at a location above the closed lower end  1   a  of the cylindrical body and below the transverse opening  4 . For this reason, during transportation and storage of the device, the insertion member  3  is frictionally held in place within the receptacle  1  and any accidental release of substance  6  from the chamber  7  into the transverse opening  4  and to the open upper end  1   b  of the receptacle  1  is prevented. 
     In the open release position shown in FIG. 2, after axial telescoping movement, the lower end  3   a  of the cylindrical portion of the insertion member  3  is positioned at or near the lower end  1   a  of the cylindrical body of receptacle  1  and the transverse opening  4  of the cylindrical portion of insertion member  3  is located below the sealing lip  2  of the cylindrical body resulting in a reduced volume of the chamber  7  and a release of substance  6  from the chamber  7  through the transverse opening  4  into the wide diameter longitudinal passage  5  of the cylindrical portion of insertion member  3 . In the open release position, the sealing lip  2  of the cylindrical body  1  is sealingly pressed into circumferential contact with the outer wall the cylindrical portion of the insertion member  3  at a location above the transverse opening  4  so as to prevent escape of substance  6  from the chamber  7  to the upper open end  1   b  of the hollow cylindrical body of receptacle  1  through any space between the outer wall of the cylindrical portion of insertion member  3  and the inner wall of the cylindrical body of receptacle  1  above the sealing lip  2 . On the other hand, the substance  6 , now essentially fully contained within the hollow cylindrical portion of the insertion member  3 , is accessible via the upper open end  3   b  of the insertion member  3 , for example, by manually dipping an applicator means such as a brush into the released substance  6  contained in the cylindrical body of insertion member  3  of the more or less upright held device. 
     At the start of the axial telescoping movement of the device from the closed storage position to the open release position, a certain axial compression force has to be applied to the axially opposite outer ends of the device in order to overcome an axial counter force internally developed by the device. This axial counterforce essentially consists of the frictional force between the sealing lip  2  and the inner wall of the cylindrical portion of insertion member  3  and a force resulting from any excess pressure within the chamber  7 . This latter force prior to any substantial telescoping movement, may increase as a function of the compressibility of the matter sealingly enclosed in chamber  7 , such as the liquid substance  6  to be released and air, and also as a function of the characteristics of the materials of the parts  1  and  3  of the device as well as the dimensions of these parts  1  and  3 . 
     In this context, according to the invention, the receptacle  1  is molded from an elastomeric material or any other appropriate material having elastic characteristics, while the insertion member  3  can be molded from a similar material or a relatively rigid plastic material. In a preferred embodiment both parts  1  and  3  of the device are made from polyethylene (PE). Generally, the materials and dimensions, such as the wall thicknesses of both parts  1  and  3  of the device are preferably chosen such that the receptacle  1  in its entirety is more elastic than the insertion member  3 . The insertion member can even be rigid, whereas the receptacle  1  should have a certain degree of elasticity to allow both the sealing engagement between the sealing lip  2  and the outer wall of the cylindrical portion of the insertion member  3  and the telescopic movement. With regard to the dimensions of the two parts  1  and  3  in the disassembled state, the outer diameter of the cylindrical portion of the insertion member  3  is larger than the inner diameter of the protruding sealing lip  2  and as large or almost as large as the inner diameter of the cylindrical body of receptacle  1 , while in the assembled state the peripheral wall of the cylindrical body of receptacle  1  is slightly expanded radially outwards at and in an axial zone near the sealing lip which is continuously in contact with the cylindrical portion of insertion member  3 . Accordingly, the peripheral wall of the cylindrical body of receptacle  1  is radially elastically expanded together with the sealing lip  2  such that the sealing lip  2  is expanded to the outer diameter of the cylindrical portion of insertion member  3 . Of course, the overall design is such that during the axial telescoping movement there is adequate radial space or clearance between the inner wall of the cylindrical body of receptacle  1  and the outer wall of the cylindrical portion of insertion member  3  below the sealing lip  2  so that any matter contained in the chamber  7  can flow or can be driven into the transverse opening  4 . 
     Referring to FIGS. 1 and 2, the cylindrical chamber within the cylindrical portion of insertion member  3  extends downwardly beyond the transverse opening  4  so as to provide an additional cup-shaped space between the closed lower end  3   a  and the transverse opening  4 . This cup-shaped space is preferably provided in all embodiments in which the axial length of the transverse opening  4  exceeds or substantially exceeds the relatively small axial width of the annular sealing lip  2 . This cup-shaped space ensures that, during the axial telescoping movement when the narrow sealing lip  2  is riding over the transverse opening  4 , any liquid substance  6  entering the transverse opening  4  flows down into and gathers in the cup-shaped space, instead of being driven into any radial space between the inner wall of the cylindrical body of receptacle  1  and the outer wall of the cylindrical portion of insertion member  3  above the sealing lip  2 . 
     In this connection it should be noted that a variety of embodiments have been implemented with different degrees of elasticity and different dimensions of both parts  1  and  3 . For example, the outer diameter of the device was within a range from several millimeters to several centimeters. Furthermore, the overall design of the device depends on the flowability or viscosity of the liquid or even a solid substance stored in the chamber  7 . Hence, a man skilled in the art can imagine that neither part  1  nor part  3  is restricted to a certain diameter, wall thickness, material or elasticity, respectively. 
     In the second preferred embodiment shown in FIG. 3 and 4, the hollow cylindrical body of receptacle  1  has an additional annular peripheral sealing lip  2 ′ axially spaced from the sealing lip  2  and projecting radially inwardly from the inner wall of the cylindrical body of receptacle  1 . In the closed storage position shown in FIG. 3, the additional annular peripheral sealing lip  2 ′ is sealingly pressed into circumferential contact with the outer wall of the cylindrical portion of insertion member  3  at a location above a longitudinally enlarged transverse opening  4 ′ of the cylindrical portion of insertion member  3  so as to assist in frictionally holding the insertion member  3  in place within the receptacle  1  during transportation and storage. During axial telescoping movement from the closed storage position to the open release position, shown in FIG. 4, the additional sealing lip  2 ′ is sealingly pressed into circumferential sliding contact with the outer wall of the cylindrical portion of insertion member  3  so as to assist in preventing escape of substance from chamber  7  to the upper open end  1   b  of the hollow cylindrical body of receptacle  1  through any radial space between the inner wall of the cylindrical body of receptacle  1  and the outer wall of the cylindrical portion of insertion member  3  above the lower sealing lip  2 . In the closed storage position, additional sealing lip  2 ′ being located above transverse opening  4  also prevents escape of substance through transverse opening  4  and any radial space between the inner wall of the cylindrical body of receptacle  1  and the outer wall of the cylindrical portion of insertion member  3 . 
     In the second embodiment, a second liquid or solid substance  8  to be mixed with the first substance  6  in chamber  7  is contained in the relatively wide diameter longitudinal passage  5  of insertion member  3 . The is additional sealing lip  2 ′ assists in preventing escape of substance  8  from the open upper end  1   b  of receptacle  1  via transverse opening  4 ′ in the closed storage position shown in FIG. 3. A removable cap  9  closing the upper open end  3   b  of insertion member  3  serves to prevent contamination of the second substance  8  within the hollow cylindrical portion of insertion member  3 . The lower sealing lip  2  has the same function as in the first embodiment shown in FIG. 1 and 2. of course, the removable cap  9  or any other similar closure means can also be applied in the first embodiment, especially, if the first embodiment is also used as multi-chamber ampoule device containing a second substance within insertion member  3 . It is evident that in this case the first embodiment is dimensioned in a manner that the second substance is prevented from escaping from the upper open end of the cylindrical body of receptacle  1 , for example, by fitting the insertion member  3  as tight as possible into the receptacle  1 , but still allowing axial telescoping movement from the closed storage position into the open release or mixing position. In this regard, the use of a plug instead of a cap as closure means may be more appropriate as a radial expansion effect can be achieved by the plug. 
     In both embodiments according to FIGS. 1 to  4 , the single substance or the mixed substances, respectively, can be applied by means of an applicator tool (not shown) like a brush which is dipped into the insertion chamber  3  in the open release position of the device. The axial telescoping movement of parts  1  and  3  is manually achieved simply by pressing together both parts with two fingers of one hand. 
     FIG. 5 shows a modification of the first embodiment in which a brush like applicator tool  10  depends from the inner surface of the cap  9 . 
     FIG. 6 shows, in the closed storage position, a further development of the first embodiment including two insertion members  3 ,  3 ′ and containing three substances  6 ,  8 ,  12 . The upper innermost insertion member  3 ′ is closed by means of a removable plug  11 . The third chamber defined within the cylindrical portion of the upper insertion member  3 ′ contains a third liquid or solid substance  8  which is mixed within the third chamber with the first substance  6  contained in the first chamber  7  of the cylindrical body of receptacle  1  and the second substance contained in the second chamber of the cylindrical portion of lower insertion member  3  when the insertion members  3 ,  3 ′ and the receptacle  1  are telescopingly moved towards one another from the closed storage position to the open release position (not shown). Likewise, it is principally possible to add even further correspondingly narrower insertion members (not shown)  3 ″,  3 ′″ etc. 
     It has to be noted that in the multi-chamber embodiment shown in FIG. 6 sealing lip  2  and additional sealing lip  2 ′ are not only provided in the cylindrical body of receptacle  1  below and above transverse opening  4  of the first insertion member  3  in the storage position of the device, respectively. The same principle as already shown in FIG. 3 is also implemented on the inner wall of the cylindrical portion of insertion member  3  which also has a sealing lip  2  and an additional sealing lip  2 ′ being, in the storage position, located above and below the transverse opening  4  of the second insertion member  3 ′. Hence, as outlined in connection with embodiment shown in FIG. 3 escape of substance through transverse openings  4  and any radial clearance between receptacle  1  and first and second insertion member  3 ,  3 ′, respectively, is reliably prevented in both positions, the closed storage position and the open release position. 
     Preferably, the first or lower insertion member  3  is also molded from an elastic material, while the upper or second insertion member  3 ′ can be made from a rigid material. The embodiment shown in FIG. 6 can be further developed by providing a second sealing lip on the inner wall the cylindrical body of receptacle  1 , such as lip  2 ′ shown in FIG. 3, and/or an additional sealing lip on the inner wall of insertion member  3 . 
     The ampoule device shown in FIG. 7,  8  and  9  is a third preferred embodiment which comprises a modified insertion member  30  the open upper end  30   a  of which, in the closed storage position illustrated in FIG. 7, is flush with the open upper end  1   b  of the cylindrical portion of receptacle  1 . The transverse opening  40  in the outside wall of cylindrical portion of the insertion member substantially extends from the closed lower end  30   a  to the open upper end  30   b  of insertion member  30  and circumferentially extends over substantial peripheral portions of the outside wall. In the shown embodiment, the outside wall is reduced to two opposite struts  31  connecting the relatively short cylindrical closed lower end  30   a  and the rather short ring-shaped open upper end  30   b  of insertion member  30 . 
     In the closed storage position shown in FIG. 7, the substance  6  within the chamber  7  is sealed off by means of the closed lower end  30   a  of the insertion member  30  and the sealing lip  2 , as explained in connection with the first embodiment shown in FIG. 1 and 2. As the upper ends  1   b  and  30   b  of the parts  1  and  30  are flush there is practically no danger of inadvertently displacing the insertion member  30  into the receptacle  1 . The open release position shown in FIG. 8 is preferably achieved by inserting a brush-like tool  100  through the open upper end  30   b  into the insertion member  30  down to the bottom of the cup-shaped closed lower end  30   a  and then pressing downwards the insertion member  30  by means of tool  100  until the open release position shown in FIG. 8 is reached. In this position the upper end  30   b  of the insertion member  30  may engage the sealing lip  2  or may be spaced therefrom at a location above the sealing lip  2 . Of course, in this embodiment the size of the transverse opening  40  can be reduced to that of the other embodiments or, alternatively cut outs can be provided in the outer wall of the insertion member  30  between the lower end  30   a  and the upper end  30   b.    
     Furthermore, the upper open end  1   b  of the receptacle  1  may be provided with a closure means such as a cap in order to store a second substance in the insertion member  30 . Preferably, the outer diameter of the open upper end  30   b  is slightly larger than that of the closed lower end  30   a  of the insertion member  30 . 
     The ampoule device shown in FIG. 1 presents a fourth preferred embodiment of the present invention comprising a modified insertion member  300  including a coaxially extending tubular portion  310  integrally formed on top of the cylindrical portion having a smaller outer diameter than the cylindrical portion and ending on its upper end in an open tip  310   b . The longitudinal passage  50  is provided in form of a narrow conduit extending from the cylindrical body of insertion member  300  into the tubular portion  310  up to the open tip  310   b . Preferably, the insertion member  300  includes a manipulating means  320  in form of two projections diametrically radially extending outwards from the cylindrical portion at a location which allows the axial telescoping movement of the receptacle  1  and the insertion member  300  towards one another. In the closed release position (not shown) the projections may abut the upper open end  1   b  of receptacle  1 . 
     The modified embodiment shown in FIG. 11 differs from the embodiment of FIG. 10 in that the insertion member  300 ′ comprises radial projections  320 ′ which are similar to the projections  320 , however, which are integrally connected to two diametrically opposed longitudinal arms  330  extending axially downwards in parallel and in spaced relation to the outer wall of receptacle  1  and ending in a radially outwards extending ring-like portion  335  surrounding receptacle  1 . In the open release position shown in FIG. 11, the portion  335  terminates shortly above the closed lower end  1   a  of receptacle  1 . 
     The tubular release portion  310  of the embodiments of FIGS. 10 and 11 is tapered towards the open upper tip  310   b  and the longitudinal passage  50  extending up to the open tip is provided in form of a small diameter conduit, achieving a nozzle-like action during telescoping axial movement. 
     It is, of course, possible to exchange receptacle  1  of FIGS. 10 and 11 by a cascade like system of one receptacle  1  with one or more correspondingly narrower additional cylindrical insertion members  3 ,  3 ′ as shown in FIG. 6 in order to provide a mixture of two or more substances  6 ,  8 ,  12  through tubular release portion  310 . 
     In a modification of the fourth embodiment, shown in FIG. 12 in the closed storage position, the ampoule device comprises an insertion member  350  having a release portion  340  in form of an essentially cylindrical applicator, for example a lip applicator, the outer diameter of which is larger than that of the cylindrical portion of the insertion member  350 . The longitudinal passage  50  extends up to the open upper end  340   b  of release portion  340  and is again designed in form of a small diameter conduit. The open upper end  340   b  has an essentially plane end face which is inclined with respect to the longitudinal axis of insertion member  350 . 
     FIG. 13 shows a modified release portion  360  replacing release portion  340  in the embodiment of FIG.  12 . The release portion  360  is designed in form of a bulgy dropper made of a soft elastomeric material and having an intermediate part of an outer diameter larger than that of the cylindrical portion and ending in an open droplet tip  360   b  of reduced outer diameter. The longitudinal passage  50  is designed in form of a small diameter conduit in the cylindrical portion and expands to a larger diameter chamber within the intermediate part of the dropper and reduces again to a small diameter outlet in the droplet tip. 
     In the embodiments of FIGS. 10 to  13 , the transverse opening  4  of the cylindrical portion of insertion body  300 ,  350  has an essentially circular cross section and the sealing lip  2  of the cylindrical body of receptacle  1  has an essentially half-circular cross section of a half-diameter larger than, but in the order of magnitude of that of the transverse opening, particularly, if a second sealing lip  2 ′ is not present. Hence, during telescoping movement, when the lip  2  is riding over the transverse opening  4  the substance  6  can easily flow into the transverse opening  4 . Furthermore, the longitudinal passage  50  of these embodiments, apart from that of FIG. 13, has a smaller inner diameter than the transverse opening  4 , particularly in the embodiments shown in FIG. 10 and 11 in order to eject the substance from the open upper tip  310   b  during telescoping movement. 
     In the ampoule device of FIG. 12 the receptacle  1  has a longitudinal window  410  axially extending from the open upper end  1   b  of the cylindrical body of receptacle  1  downwards to a location which, in the closed storage position, is above the transverse opening  4  of the cylindrical portion of the insertion member  350 . The insertion member  350  has a projection  400  radially extending outwards from the cylindrical portion through the longitudinal window  410  for sliding movement therein during telescoping movement. The outer part of the projection  410  protruding from the longitudinal window may be designed in form of a slider for manual operation. 
     The ampoule device of FIG. 14 substantially corresponds with the device of FIG.  10  and makes use of a separate manipulating member  500  instead of the integrally molded manipulating portion  320 . The manipulating member  500  includes a tubular upper portion  500   b  enclosing an outlet passage  510  and a lower portion integrally formed therewith and enclosing two axially extending inlet passages  520 . The inlet passages  520  are designed for receiving the tubular portion  310  on top of the cylindrical portion of an insertion member  300  and are in fluid communication with the outlet passage  510 . The manipulating member  500  includes a shoulder  530  transversely extending outwards with respect to the axially extending outlet passage  510  for manually performing telescoping movement between the two receptacles  1  and insertion members  300  when received in the manipulating member  500 . This embodiment allows for mixing the substances released from the two insertion members  300  during telescoping movement prior to release from the outlet passage  510 . The man skilled in the art will recognize that the manipulating member  500  also may have three or even more integrated axially extending inlet passages  520 , or only a single inlet passage  520 . Preferably, a sealing lip  312  is provided near the open upper end of the tubular release portion  310 . 
     In each one of the embodiments of the present invention, a spring means  600 , shown in FIG. 16, may be provided between the closed lower end  300   a  of insertion member  300  and the closed lower end  1   a  of receptacle  1 . 
     In a preferred embodiment, the spring means  600  is integrally formed with the lower end  300   a  of insertion member  300 . This allows a repeated partial release of the substance. 
     The ampoule device of FIG. 15 substantially corresponds with the device of FIG.  10  and makes use of a separate manipulating member  700  instead of the integrally molded manipulating portion  320 . The manipulating member  700  is designed for receiving the receptacle  1  and insertion member  300  in the closed storage position and has retractable slider  710  for manually performing telescoping movement between the receptacle and the insertion member. Member  700  has a pencil like body with a closed lower end and an upper end with a throughgoing hole  720  for inserting the tubular portion  310  of insertion member  300 . Furthermore, the pencil like body comprises a side opening in form of a recess  730  for receiving the prefilled device parts  1  and  300  in the closed storage position. The assembled parts  1  and  300  are embedded within the recess  730  after having inserted tubular portion  310  into throughhole  720 . The slider  710  of this embodiment consists of lever member  710   a  pivotally attached to the pencil like body at one end. A metallic blade-spring member  710   b  is attached to the other free end of lever member  710   a  with one end. The other free end of spring member  710   b , elastically received in member  700 , abuts against the bottom of receptacle  1  embedded in the recess  730 . Upon pressing down lever member  710   a  spring member  710   b  moves receptacle  1  upwards and the substance  6  is forced out through opening  310   b . Afterwards, lever member  710   a  is again retracted to the position shown in FIG.  15  and the empty parts  1  and  300  are removed from recess  730 . The member  700  is preferably molded from a rigid plastic material. 
     In the embodiment of FIG. 17 the modified receptacle  800  includes a base portion  810  radially extending outwards from the cylindrical body at the closed lower end  800   a  thereof for manually performing the telescoping movement in cooperation with an integrally molded manipulating means  820  and base portion  810  supporting the ampoule device in an upright position. Manipulating means  820  is similar to manipulating means  320  and comprises a gripping surface. As seen in the left hand part of FIG. 17, a plurality of upright standing ampoule devices are joined together in a line with a strip like fastening means  830 . Before using one ampoule device the fastening means  830  is torn apart behind the device or, alternatively, the device body is drawn off from an adhesive strip-like fastening means  830 . This allows to subsequently use small amounts of a critical substance (e.g. for eye drop or nose spray appliances). 
     FIG. 18 shows a modification of the separate manipulating member  500  shown in FIG.  14 . The modified manipulating member  800  consists of an outer part  840  and an inner part  850  received in a hollow lower portion of the outer part  840  as seen in FIG.  18 . The tubular upper portion of the modified manipulating member  800  encloses the outlet passage  810 . The inner part  850  encloses the two axially extending inlet passages  820 . The inlet passages  820  are designed for receiving the tubular portion  310  on top of the cylindrical portion of an insertion member  300  and are in fluid communication with the outlet passage  810  via a static mixing zone  860 . The manipulating member  800  also includes the shoulder  830  transversely extending outwards with respect to the axially extending outlet passage  810  for manually performing telescoping movement between the two receptacles  1  and insertion members  300  when received in the inlet passages  820  of manipulating member  800 . This modified embodiment allows for a better mixing of the substances released from the two insertion members  300  during telescoping movement prior to release from the outlet passage  810  as it allows, due to the two-part construction, a particular design of the static mixing zone  860  above the outlets of the inlet passages  820 . 
     The manipulating members  500  and  800  are molded from a preferably elastomeric plastic material. 
     A specific implementation of the embodiment shown in FIG. 1 and 2 had the following dimensions in millimeter: 
     Receptacle  1 : 
     longitudinal length: 19.0 
     outer diameter: 7.0 
     inner diameter: 5.5 
     half-diameter of sealing lip  2 : 0.25 
     Insertion member 3: 
     longitudinal length: 25.5 
     outer diameter: 5.4 
     inner diameter: 4.0 
     diameter of transverse opening  4 : 2.0 
     A specific implementation of the embodiment shown in FIG. 10 had the following dimensions in millimeter: 
     Receptacle  1 : 
     longitudinal length: 29.0 outer diameter: 5.8 
     inner diameter: 4.0 
     half-diameter of sealing lip  2 : 0.2 
     Insertion member 300: 
     length of lower cylindrical portion: 29.0 
     outer diameter of lower cylindrical portion: 3.9 
     diameter of transverse opening  4 : 1.5 
     diameter of longitudinal passage  50 : 0.5 
     length of upper tubular portion  310 : 28.0