Abstract:
An automated analyzer system. The system has a rack for automated analyzer systems, the rack comprising at least one position for taking up at least one cartridge; at least one drive for agitating the content of the at least one cartridge; at least one RFID antenna for reading RFID tags of the at least one cartridge and at least one printed circuit board for operating the drive, e.g. a motor.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    The present application claims priority of Luxembourg Patent Application No. LU 92 703 filed on Apr. 29, 2015. The aforementioned application is hereby incorporated by reference in its entirety. 
       BACKGROUND OF THE INVENTION 
       [0002]    1. Field of the Invention 
         [0003]    The field of the invention relates to a rack for automated analyzer systems. 
         [0004]    2. Brief Description of the Related Art 
         [0005]    Automatic analyzer systems in clinical diagnostics have to be supplied with different liquids to run biochemical processes and/or have to be loaded with operating fluids for integrated technical devices. 
         [0006]    Currently analyzer systems use either individual bottles or cartridges. Individual bottles are inserted in racks, which are then placed into a reagent or sample-loading bay. Sample-loading bays are often cooled. Agitation for some contents to keep particles in suspension can be provided by some mechanical interface. On common instruments this mechanical interface is an oscillating gear rack or a gear wheel. This mechanical interface interacts with a gear on the rack, providing rotational movement to the reagent bottle or reagent container. 
         [0007]    Reagent cartridges combine several reagents into one container that has corresponding cavities. The cartridges are either placed directly into the reagent bay or via cartridge carriers. One or more inserted separate containers in the cartridge can be rotated for agitation. Cartridges offer a better reagent to space ratio than individual bottles. 
         [0008]    The existing reagent containers or cartridges cannot be agitated separately and are limited in respect to the width and the agitation interface. 
         [0009]    Agitation can only be used for all racks in a reagent bay simultaneously. If agitation needs to be stopped before pipetting, agitation is stopped for all racks during pipetting of one reagent. Thus, there is a need for cartridges, which can be agitated separately. 
         [0010]    Existing systems use bar code readers to identify rack and reagent type. Alternatively they use RFID antennas for reading out information. These antennas have to be placed very close to the respective tag, which causes additional efforts in protection against humidity. Optical systems like bar code readers or cameras are sensitive against condensation, e.g. in cooled systems or contamination with particles. 
         [0011]    The design of a loading bay is rather complex because of the need for agitation mechanism and agitation rack interface. Since a reagent bay is usually cooled, condensed water has to be taken into account. 
       SUMMARY OF THE INVENTION 
       [0012]    It is an object of the invention to provide a rack for automated analyser systems which provides more flexibility as regards agitation and identification of samples. 
         [0013]    The instant invention provides a rack for automated analyzer systems, the rack comprising at least one position for taking up at least one cartridge; at least one drive for agitating the content of the at least one cartridge; at least one RFID antenna for reading RFID tags of the at least one cartridge and at least one printed circuit board for operating the drive, e.g. a motor. 
         [0014]    The at least one cartridge may comprise at least one container or bottle. 
         [0015]    It is intended that at least one cartridge can comprise at least one stationary and/or movable container or bottle. 
         [0016]    The at least one drive and the at least one cartridge can be connected by means for agitating the at least one cartridge or the at least one container or bottle. A gear drive is one possible embodiment for such a connection. 
         [0017]    The at least one container or bottle of the at least one cartridge may be connected to at least one neighboring container to transfer its agitation. A row of gear drives may represent such a connection to transfer rotation from the drive. 
         [0018]    The rack may comprise induction coils to transfer power to the drive and to enable communication with the automated system for operation of the rack. 
         [0019]    The rack may further or alternatively comprise electrical contacts to transfer power and to enable communication with the automated system. 
         [0020]    The at least one cartridge may comprise 2D codes for identification. 
         [0021]    The rack may further comprise a LED to indicate the status of the rack to a user for instance. 
         [0022]    The rack may comprise a power source for powering the at least one drive. 
         [0023]    The at least one drive and the at least one cartridge or the at least one container or bottle may be connected by gear-wheels for agitation of the at least one cartridge. 
         [0024]    The rack may have pullout leg supports so that the rack is able to stand alone outside the automated analyzer system 
     
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
         [0025]    The invention will now be described on the basis of figures. It will be understood that the embodiments and aspects of the invention described in the figures are only examples and do not limit the protective scope of the claims in any way. The invention is defined by the claims and their equivalents. It will be understood that features of one aspect or embodiment of the invention can be combined with a feature of a different aspect or aspects of other embodiments of the invention. 
           [0026]      FIG. 1  is a schematic overview of a rack with inserted cartridges. 
           [0027]      FIG. 2  is a schematic overview of loading bays with inserted racks. 
           [0028]      FIG. 3  is a top view onto a rack. 
           [0029]      FIG. 4A  is a schematic depiction of drive. 
           [0030]      FIG. 4B  is a sectional view of the drive show in in  FIG. 4A . 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0031]    The invention provides a new intelligent rack  5  that accepts disposable cartridges  10  with any kind of content therein. The cartridges  10  may only provide one volume or can be separated to provide separate volumes for different kinds of content.  FIG. 1  shows on the right part of the rack  5  a cartridge  10  that is separated to have two parts for taking up content. 
         [0032]    A rack within the meaning of the instant invention shall be understood as a framework into that cartridges or bottles may be placed. A rack can be put into an automated analyzer system carrying cartridges or bottles with samples or buffer. 
         [0033]    The intelligent rack  5  features a build in PCB  20 , which carries RFID antennas for identification of inserted cartridges by reading out RFID tags  30 , which are connected to the respective cartridge as well as a status LED. 
         [0034]    The rack  5  has a build in motor  40 , which provides agitation to at least one movable cartridge  10  or container or bottle of a cartridge  10 . The PCB  20  has an induction coil, which provides power to the rack  5 , when inserted into the reagent-loading bay. The reagent loading bay may feature corresponding induction coils to provide power to the racks  5 . Information about the content of a cartridge  10 , container or bottle of a cartridge  10  can be transmitted through the coils between the rack  5  and the analyzer system. It is an advantage that a rack  5  of the present disclosure enables individual agitation and further allows for different reagent specific agitation profiles without the need that the system provides a drive for agitation. The motor of a rack according to the instant invention is used for agitation of the content of a cartridge or bottle, but is not used for moving the rack or cartridges or bottles placed into the rack within the automated analyzer system. 
         [0035]      FIG. 1  shows an embodiment of a new intelligent rack  5  with a rack handle  15 . One or more cartridges  10  (the figure shows a design for up to two cartridges  10 ) can be inserted into the rack  5 . Each cartridge  10  may have a RFID tag  30  containing information about the content of the respective cartridge. An antenna on the rack PCB  20  can read out the RFID tag. A recess  25  located at the bottom side can be used for locking the rack in the loading bay by a hook (not shown) engaging into the recess. 
         [0036]    A processor on the PCB  20  further controls the agitation motor  40 , the status LED  50  and processes reagent data. The PCB  20  communicates with the instrument electronics via an induction coil, which may also provide power to the rack. An identification of the content of cartridge  10 , comprised container or bottles can also be achieved by using barcodes on the cartridge  10 . 
         [0037]    The cartridge  10  on the left side of the rack shown in  FIG. 1  comprises  4  stationary container or bottles  60 . The most right stationary container or bottle  60  is connected via gear wheel  70  with the motor or drive  40 . 
         [0038]    A rack  5  may have an interface  100  to communicate or exchange data with the automated analyzer system. The counterpart of the interface is located within the loading bay. 
         [0039]      FIG. 2  shows lanes  80  of a loading bay comprising on the right side intelligent racks of the instant disclosure as well as an already known reagent racks. The lanes  80  do not need means for agitation, because they are integrated into the intelligent racks of the instant disclosure. 
         [0040]    Fins  90  separate the loading bay into lanes and the fins  90  may provide cooling of the cartridges  10  and their content. In case wider racks  5  are necessary, the fins  90  can be removed accordingly. This results in more flexibility for using a variety of racks and container with different sizes and shapes. 
         [0041]      FIG. 3  shows a top view onto a rack of the instant disclosure showing the pullout leg supports  16  so that the rack can be safely placed onto a surface outside of the analyzer system without the danger of tipping over. 
         [0042]      FIG. 4  shows in A on the left side an overview of the drive for agitating stationary bottles or container and in B on the right side a sectional view through the overview. Gear wheel  70  is mounted directly onto the motor shaft of motor  40  and engages into outer gear wheels  71 . The outer gear wheels have on their upper side driver pins  72 , which engage into the bottom side of stationary bottles or container  60  that are placed onto it and thus agitate the stationary bottles or container  60 . 
         [0043]    The use of an intelligent rack according to the instant disclosure facilitates also the design of a loading bay and allows using racks of different width, wherein agitation of a rack is independent from the loading bay. Different sized containers or bottles can be supported within racks of a different width. The resulting high degree of flexibility for all kinds of substances is one advantage of the subject matter of the present invention. 
         [0044]    Racks according to the instant disclosure may be retrofitted even on already delivered instruments to allow for the use of cartridges according to the instant disclosure. 
         [0045]    The use of stationary coils and corresponding coils integrated into the rack allows for replacing moving parts for agitation in a loading bay. Thus, the reliability of a loading bay is improved. In case that a rack breaks, the user can replace such a rack without the help of field service engineering. 
         [0046]    A further advantage of a rack according to the instant disclosure is that the rack is able to recognize the content of a cartridge, which is placed onto the racks and can thus adapt for instance the agitation profile. 
         [0047]    It is further possible that cartridges which are inserted for the first time in a rack can be treated differently than during long term storage e.g. with more aggressive agitation for initial suspension of the content like settled particles or beads. 
         [0048]    A system using cartridges of the instant disclosure offers the possibility that agitation can be stopped rack wise rather than per loading bay, e.g. for pipettor access to a particular reagent. 
         [0049]    In addition, turning off agitation of individual racks may reduce noise generated from the agitation mechanism and reduces power consumption, in case that the particular rack is no longer needed for scheduled sample tests. Turning off agitation entirely due to the increased suspension capabilities of a rack of the instant disclosure can also reduce standby noise. 
         [0050]    LED indicators on the intelligent rack provide direct feed back to the user about the rack status e.g. in use, not in use—removable or not removable etc. 
         [0051]    A rack of the instant disclosure does not need a battery or electrical contacts due to the proposed use of induction coils. Thus, mechanical wear has no longer to be taken into account.