Abstract:
A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin&#39;s lymphoma or non-Hodgkin&#39;s lymphoma. The person may be a high-risk subject. In one embodiment, a plasma sample from a person is obtained. The level of at least one protein listed in Table S3 in the plasma sample is measured. The level of at least one protein in the plasma sample is compared with the level in a normal or healthy subject. The lymphoma is diagnosed based upon the level of the at least one protein in the plasma sample in comparison to the normal or healthy level.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims priority to U.S. Provisional APPLICATION Ser. No. 61/565,036, filed Nov. 30, 2011, titled “BIOMARKERS FOR HODGKIN&#39;S LYMPHOMA”, hereby incorporated by reference in its entirety. 
    
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT 
     The invention was made with Government support under Contract DE-AC05-76RLO1830, awarded by the U.S. Department of Energy. The Government has certain rights in the invention. 
    
    
     TECHNICAL FIELD 
     This invention relates to biomarkers for lymphoma. More specifically, this invention relates to plasma biomarkers for detecting Hodgkin&#39;s lymphoma or non-Hodgkin&#39;s lymphoma. 
     BACKGROUND OF THE INVENTION 
     In the presence of human immunodeficiency virus (HIV) infection, non-Hodgkin&#39;s lymphoma (NHL) and Kaposi sarcoma (KS) were the first malignancies used to define acquired immune deficiency syndrome (AIDS). People with HIV infection are also at increased risk of a number of other cancers. As people with HIV infection live longer due to highly active antiretroviral therapy (HAART), the incidence of these non-AIDS-defining cancers has increased among HIV-infected individuals. One of the most common of these malignancies is Hodgkin&#39;s lymphoma (HL), and it has been estimated that people with HIV/AIDS have a 5.6- to 14.7-fold increased risk of developing HL compared to the general population. 
     HL is a solid tumor that is comprised of no more than 2% of the cancerous B lymphocytes. Instead, these lymphocytes secrete a wide range of cytokines that attract numerous normal leukocytes that then comprise the large majority of the tumor. Thus, HL is largely seen as an uncontrolled inflammatory disease. In people with immunosuppression, HL is believed to result from the Epstein-Barr virus (EBV). EBV is present in nearly all adults, but typically only causes HL when the immune system is suppressed, such as with HIV infection. 
     The increase in non-AIDS-defining cancers has created a greater need for the early detection of these malignancies in this susceptible population. It seems likely that HIV-infected individuals would benefit from a routine, non-invasive screen for HL, but no such screen exists. Rather, HL patients are identified after they become symptomatic. Chemotherapy and radiation therapy have been shown to be very effective at causing HL remission, but morbidity and mortality associated with these treatments is substantial. Early-stage HL is generally treated less intensively, suggesting that early detection of HL would result in less treatment-related toxicity. Cancer treatment strategies for HIV-infected individuals with HL are the same as for non-AIDS subject, but HIV-infected patients require additional vigorous supportive care (HAART, antifungals, neutrophil-simulating growth factors). 
     What is needed is a blood-based test to detect lymphoma earlier, when the tumor burden is much smaller, which would allow for less severe therapy and reduce long-term mortality and morbidity associated with current treatments. 
     SUMMARY OF THE INVENTION 
     In one embodiment of the present invention, a biomarker for detecting lymphoma in a person is disclosed. The biomarkers include at least one protein listed in Table S3. 
     The lymphoma may be Hodgkin&#39;s lymphoma or non-Hodgkin&#39;s lymphoma. The at least one protein is found in plasma, and the person is a high-risk subject. 
     In another embodiment of the present invention, a method of detecting lymphoma in a person is disclosed. The method includes obtaining a plasma sample from the person. The method further includes measuring the level of at least one protein listed in Table S3 in the plasma sample. The method also includes comparing the level of the at least one protein in the plasma sample with the level in a normal or healthy subject; and diagnosing the lymphoma based upon the level of the at least one protein in the plasma sample in comparison to the normal level. In one embodiment, the obtaining a plasma sample from the person further comprises providing a reagent that reacts with proteins in the plasma sample to detect the presence of lymphoma. The reagent may be an antibody. 
     In another embodiment of the present invention, a test kit for diagnosing lymphoma in a person is disclosed. The test kit includes an antibody-based assay that measures a plurality of plasma biomarkers selected from the group consisting of the biomarkers of Table S3; and instructions for conducting the antibody-based assay. 
     In another embodiment of the present invention, a diagnostic system for detecting the presence of lymphoma in a person is disclosed. The system includes a plurality of protein assays measuring a plurality of plasma biomarkers. The plasma biomarkers are selected from the biomarkers of Table S3. Concentration levels or peak intensity values of at least one of the plasma biomarkers is modified by the presence of the lymphoma in the person. The system also includes a detector for detecting the plasma biomarkers. 
     In one embodiment, the detector is a mass spectrometer. In another embodiment, the detector includes at least one labeled antibody specific for a biomarker of Table S3. 
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     The present invention is directed to methods, diagnostic systems, kits, and biomarkers for detecting lymphoma in a patient. These biomarkers may form the basis for a blood-based test for early detection of lymphoma and may be used clinically. 
     To identify candidate biomarkers for Hodgkin&#39;s Lymphoma (HL) detection, plasma samples from HIV-infected patients were analyzed, with or without HL, using accurate mass tag and time (AMT) tag proteomics, and thereby identified a set of 60 proteins. As a group, these proteins are associated with both cancer and inflammation and therefore are promising candidate biomarkers for early detection of HL. 
     Materials and Methods 
     Ethics Statement. 
     The study protocol was approved by the George Washington University Medical Center Institutional Review Board. Written informed consent was obtained from all study participants. Additional approval from the PNNL Institutional Review Board, which included a review of the George Washington University Medical Center IRB approval, was obtained before samples were transferred to PNNL. 
     Human Subjects and Sample Processing.
         Frozen, human plasma samples were provided by the AIDS and Cancer Specimen Resource (San Francisco, Calif.). The control subjects (HIV-infected without HL) were chosen to approximately match the cases (HIV-infected with HL) based on gender and age (Table 1). In most cases, plasma samples were collected from HIV-infected subjects with HL that had not received HL chemotherapy within at least 30 days (n=12). Information on chemotherapy was unknown for some cases (n=9) and one sample was known to have been collected within 30 days of chemotherapy. For all processing and analytical steps, samples were blocked based on HL status and randomized. The 12 most abundant plasma proteins were depleted using the Proteome Purify™ 12 immunodepletion resin (R&amp;D Systems), according to the manufacturer&#39;s protocol. The remaining plasma proteins were precipitated using ice-cold trichloroacetic acid at a final concentration of 10%, followed by overnight incubation at 4° C. and centrifugation at 14,000×g for 5 minutes. The pellet was washed with cold acetone and dried at room temperature for 5 minutes prior to suspension in 25 μL of 100 mM ammonium bicarbonate, 8 M urea, 2 M thiourea and 5 mM dithiothreitol, and heating to 60° C. for 30 min. The samples were then diluted 4-fold with 100 mM ammonium bicarbonate and CaCl 2  was added to 1 mM. Methylated, sequencing-grade trypsin (Promega, Madison, Wis.) was added at a substrate-to-enzyme ratio of 50:1 (mass:mass) and incubated at 37° C. for 15 h. Peptides were then purified by binding to a 1 mL SPE C 18  column (Supelco, Bellefonte, Pa.) and eluting with 1 mL of methanol. After concentration in a SpeedVac, the samples were dissolved in 25 mM ammonium bicarbonate and frozen at −20° C. until analysis.       

     
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Subject characteristics. 
               
             
          
           
               
                   
                 HIV+ 
                 HIV+/HL+ 
               
               
                   
                   
               
             
          
           
               
                 Number 
                 14 
                 22 
               
               
                 Gender (M/F) 
                 10/4 
                 20/2 
               
               
                 Age (min-max) 
                 53.9 ± 5.9 a  (42-63) 
                 49.2 ± 8.8 (34-66) 
               
               
                 CD4 count b   
                 404 ± 380 
                 203 ± 224 
               
               
                 CD4 count &lt; 200 c   
                 4 (29%) 
                 12 (55%) 
               
               
                 HAART d  (yes, no, 
                 12, 1, 1 
                 11, 4, 7 
               
               
                 unknown) 
               
               
                 Lymph node 
                 NA e   
                  6 
               
               
                 involvement 
               
               
                   
               
               
                   a Mean ± standard deviation. 
               
               
                   b Units are CD4-positive cell counts per μL blood. 
               
               
                   c CD4 counts of less than 200/μL has been used to define the presence of AIDS in HIV positive subjects. 
               
               
                   d Indicates current usage of HAART antiretroviral therapy at the time of the blood draw. 
               
               
                 “Unknown” indicates that HAART usage at the time of the blood draw is unknown. Prior usage is unknown for all subjects. 
               
               
                   e NA, not applicable. 
               
             
          
         
       
     
     Liquid Chromatography-Mass Spectrometry. 
     Peptide samples were analyzed using a custom-built, automated, high-pressure nanocapillary liquid chromatography (HPLC) system coupled on-line to a LTQ-Orbitrap mass spectrometer (Thermo Fisher Scientific). The reversed-phase capillary column was prepared by slurry packing 3-μm Jupiter C18 bonded particles (Phenomenex, Torrence, Calif.) into a 65-cm-long, 75-μm-inner diameter fused silica capillary (Polymicron Technologies, Phoenix, Ariz.). The mobile phase consisted of 0.2% acetic acid and 0.05% trifluoroacetate in water (A) and 0.1% trifluoroacetate in 90% acetonitrile, 10% water (B). After loading 5 μL (2.5 μg total) of peptides onto the column, the mobile phase was held at 100% A for 50 min. Exponential gradient elution was performed by increasing the mobile phase composition from 0 to 55% B over 115 min. The HPLC column was coupled to the mass spectrometer by an in-house manufactured electrospray ionization interface. The heated capillary inlet temperature and electrospray voltage were 200° C. and 2.2 kV, respectively. Data were acquired for 100 min, beginning 65 min after sample injection (15 min into start of buffer B gradient). Orbitrap spectra (AGC 5×10 5 ) were collected from 400-2000 m/z at a resolution of 100,000. 
     The mass spectra were analyzed using the AMT tag approach. The peak lists for each analysis were matched against a mass tag database containing 30,573 tryptic peptides that were previously identified from LC-MS/MS analyses of human plasma. An estimate of the false-positive rate for peptide identifications in our analysis, which was &lt;6%, was obtained by searching the sequence-reversed database. 
     Statistics. 
     There were 76 mass spectrometry runs included in the proteomics data, including at least two analyses for each of the 36 samples. A total of 6460 unique peptides were initially identified. The data-analysis process first removed peptides for which there were insufficient identifications to perform a statistical analysis, which reduced the peptide number to 3814. Next, the peptide abundance measurements were normalized via regression based on all the peptide signals for that mass spectrometer run and then averaged across replicate runs for each sample. The averaged signal intensities were normalized for each sample based on the median absolute deviation of the signal intensity for all peptides identified in each sample. Finally, the data were subjected to two statistical tests to determine peptides having differential abundance due to either signal intensities or presence-absence. A non-parametric Mann-Whitney test was performed using MatLab 2009 to compare signal intensities. Differences in detection incidence was determined using a modified Chi-square test, called a G-test. Using either test, 647 peptides were identified with a p-value of 0.05 or less. 
     Normalized peptide abundance values were used for protein inference; the peptide abundance measurements were weighted and combined to calculate the relative protein abundances in the two groups using RRollup within DAnTEm. Only proteins represented by two or more unique peptides were analyzed. Peptide redundancy was reduced with Protein Prophet and by manually selecting characterized proteins over predicted or hypothetical proteins. 
     Ingenuity Pathway Analysis. 
     Differentially regulated proteins were analyzed for common biological functions using Ingenuity Pathway Analysis (IPA; Ingenuity Systems, Mountain View, Calif.) software. To infer significant biological functions, all proteins that were significantly different between groups and their corresponding ratiometric values (HL+/HL−; minimum of 1.5-fold change) were analyzed by IPA. The significance values for biological function were determined using the right-tailed Fisher&#39;s Exact Test. 
     Results and Discussion 
     To identify potential circulating biomarkers for HL in a susceptible population, we used the AMT tag LC-MS approach to compare the plasma proteomes from 36 HIV-infected patients with or without HL. The HIV-infected patients without HL served as the control group to identify protein changes associated with HL. The relatively high-throughput characteristics of this approach enabled duplicate analyses of each of the 36 plasma samples, thereby improving data quality. The subject characteristics are described in Table 1. The proteomics analysis identified 3814 peptides across all of the samples, which corresponded to 629 proteins. Of these 3814 peptides, 647 were significantly different between the two disease states, which corresponded to 152 proteins (Tables S1 and S2). Sixty of these proteins met our criteria of being both significantly different between the two groups and having at least 1.5-fold difference in the normalized signal (Table S3). This protein list included well-known acute-phase inflammatory proteins, including C-reactive protein and serum amyloid proteins. To better identify common biological functions within these 60 proteins, Ingenuity Pathway Analysis (IPA) was utilized. In general, proteins that were associated with immune responses and cancer were highly represented in the list of significantly altered biological functions. Many of the proteins we identified are known to be secreted by white blood cells, such as those that infiltrate HL tumors, or by the liver, an important component of the reticuloendothelial system (Table S3). Similarly, the use of IPA to identify common biological functions across the 60 proteins identified “inflammatory response” and “cancer” (Table 2), suggesting that these proteins have a biological relationship with HL. Since only 1% to 2% of the mass of an HL tumor is composed of the cancerous lymphocytes, it may be that the proteins we identified did not originate from these relatively rare cells. Rather, these proteins may be the product of a systemic inflammatory response associated with HL or due to noncancerous leukocytes that form ˜99% of the tumor mass. 
     
       
         
               
             
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Top BioFunctions and associated proteins, 
               
               
                 as defined by Ingenuity Pathway Analysis. 
               
             
          
           
               
                   
                 p-value 
                   
               
               
                 Name 
                 range a   
                 Associated proteins b   
               
               
                   
               
               
                 Inflam- 
                 3.0 × 10 −10 - 
                 AHSG, AMBP, APOE, ARHGDIB, B2M, 
               
               
                 matory 
                 1.1 × 10 −02   
                 C4A/C4B, C8A, CD14, CFD, CRP, GSN, LUM, 
               
               
                 Re- 
                   
                 MBL2, MCAM, MASP1, MSN, PPBP, PNP, 
               
               
                 sponse 
                   
                 PTGDS, PVR, SAA1, SEMA7A, TIMP1 
               
               
                 Cancer 
                 9.2 × 10 −09 - 
                 AHSG, AMPB, APOC1, APOE, ARHGDIB, 
               
               
                   
                 1.1 × 10 −02   
                 AZGP1, B2M, C4A/C4B, CD14, CFD, 
               
               
                   
                   
                 COL6A3, CRP, CST3, EFEMP1, GSN, 
               
               
                   
                   
                 IGFBP2, KRT10, MCAM, MASP1, PNP, 
               
               
                   
                   
                 PTGDS, SAA1, SELENBP1, TIMP1, YWHAG 
               
               
                   
               
               
                   a The p-values reflect the range of all the subcategories that the Ingenuity Pathway Analysis included under the header of Inflammatory Response or Cancer. That is, these two BioFunctions have 39 or 35 subcategories, respectively, and each of these subcategories show significant differences, within the range of p-values shown, between the HIV+ (without HL) and HIV+/HL+ groups. 
               
               
                   b Abbreviations are defined in Table S3. 
               
             
          
         
       
     
     At least three of the proteins we identified have been previously reported to be increased in HL subjects compared to healthy controls, including C-reactive protein, beta-2-microglobulin and lactate dehydrogenase. These prior studies examined HL in the general population, and did not focus on HIV-positive subjects. In addition, these studies measured these proteins by immunoassay, providing analytical verification as well. In the current study, the presence of HIV in the study population could be a confounding factor. For example, the HL subjects appeared to have slightly more advanced cases of HIV, on the average, as suggested by a trend (p=0.07, t-test) towards lower CD4-positive cell counts (Table 1), a result which is consistent with slightly more advanced immunosuppression. Even so, since three of the proteins we identified are increased in HL subjects without HIV, it seems clear that the results for these proteins, at least, are not confounded by differential states of HIV infection. Overall, the present study independently validates three plasma biomarkers for HL and identifies an additional 57 novel plasma proteins that appear to be promising candidate biomarkers based on their relationships with cancer and inflammation. These candidate biomarkers remain to be validated in regards to their association with HL. 
     The present invention has been described in terms of specific embodiments incorporating details to facilitate the understanding of the principles of construction and operation of the invention. As such, references herein to specific embodiments and details thereof are not intended to limit the scope of the claims appended hereto. It will be apparent to those skilled in the art that modifications can be made in the embodiments chosen for illustration without departing from the spirit and scope of the invention. 
     
       
         
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE S1 
               
             
             
               
                   
               
               
                 Identified significant peptides 
               
             
          
           
               
                   
                   
                   
                   
                 Ave HL 
                 Ave HL 
                 Ratio HL 
               
               
                   
                   
                   
                   
                 positive 
                 negative 
                 positive/ 
               
               
                 GENE 
                   
                   
                   
                 (n = 
                 (n = 
                 HL 
               
               
                 SYMBOL 
                 Protein 
                 Reference 
                 Peptide 
                 22) 
                 14) 
                 negative 
               
               
                   
               
             
          
           
               
                 — 
                 P25 
                 IPI:IPI00386965.1 
                 FVTKAEEK 
                 0.22 
                 0.21 
                 1.04 
               
               
                   
               
               
                 — 
                 CDNA FLJ33508 
                 IPI:IPI00166374.1 
                 YNDYLITIK 
                   
                 0.23 
                   
               
               
                   
                 fis, clone 
                   
                   
                   
                   
                   
               
               
                   
                 BRAMY2005094 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A1BG 
                 Alpha-1B- 
                 IPI:IPI00022895.7 
                 SLPAPWLSMAPVSWITPGLK 
                 0.45 
                 0.59 
                 0.77 
               
               
                   
                 glycoprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 AFQPFFVELTMPYSVIR 
                 7.72 
                 0.32 
                 24.32 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 ASVSVLGDILGSAMQN 
                 0.36 
                 0.61 
                 0.59 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 ATVLNYLPK 
                 7.93 
                 0.43 
                 18.58 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 AVDQSVLLMKPDAELSASS 
                 4.59 
                   
                   
               
               
                   
                 macroglobulin 
                   
                 VYNLLPEK 
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 AYAFALAGNQDKR 
                 0.15 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 DMYSFLEDMGLK 
                 6.62 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 DTVIKPLLVEPEGLEK 
                 9.70 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 GGVEDEVTLSAYITIALLEIP 
                 3.16 
                   
                   
               
               
                   
                 macroglobulin 
                   
                 LTVTHPVVR 
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 GHFSISIPVK 
                 6.81 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 GPTQEFK 
                 2.20 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 HYDGSYSTFGER 
                 5.25 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 LLIYAVLPTGDVIGDSAK 
                 9.45 
                 0.31 
                 30.49 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 LLLQQVSLPELPGEYSMK 
                 10.03 
                 0.29 
                 34.54 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 LPPNVVEESAR 
                 6.87 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 QGIPFFGQVR 
                 4.59 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 QTVSWAVTPK 
                 8.37 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 SDIAPVAR 
                 3.78 
                 1.61 
                 2.35 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 SIYKPGQTVK 
                 5.37 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 SVSGKPQYMVLVPSLLHTET 
                 12.16 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 TGTHGLLVK 
                 8.95 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 VIKPLLVEPEGLEK 
                 0.84 
                 0.99 
                 0.85 
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 A2M 
                 Alpha-2- 
                 IPI:IPI00478003.1 
                 VSVQLEASPAFLAVPVEK 
                 7.90 
                   
                   
               
               
                   
                 macroglobulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 AGFAGDDAPR 
                 13.47 
                 20.00 
                 0.67 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 DLTDYLMK 
                 18.97 
                 28.69 
                 0.66 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 DSYVGDEAQSKR 
                 0.79 
                 0.60 
                 1.32 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 EITALAPSTMK 
                 26.67 
                 40.43 
                 0.66 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 HQGVMVGMGQK 
                 10.17 
                 10.44 
                 0.97 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 SYELPDGQVITIGNER 
                 26.79 
                 39.27 
                 0.68 
               
               
                   
                 skeletal 
                   
                   
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                 ACTA1 
                 Actin, alpha 
                 IPI:IPI00021428.1 
                 YPIEHGIITNWDDMEKIWHH 
                 0.86 
                   
                   
               
               
                   
                 skeletal 
                   
                 TFYNELR 
                   
                   
                   
               
               
                   
                 muscle 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 AGFAGDDAPR 
                 13.47 
                 20.00 
                 0.67 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 DLTDYLMK 
                 18.97 
                 28.69 
                 0.66 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 DSYVGDEAQSKR 
                 0.79 
                 0.60 
                 1.32 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 EITALAPSTMK 
                 26.67 
                 40.43 
                 0.66 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 HQGVMVGMGQK 
                 10.17 
                 10.44 
                 0.97 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 SYELPDGQVITIGNER 
                 26.79 
                 39.27 
                 0.68 
               
               
                   
                 cytoplasmic 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTB 
                 Actin, 
                 IPI:IPI00021439.1 
                 TTGIVMDSGDGVTHTVPIYE 
                 36.07 
                 48.57 
                 0.74 
               
               
                   
                 cytoplasmic 1 
                   
                 GYALPHAILR 
                   
                   
                   
               
               
                   
               
               
                 ACTN1 
                 Alpha- 
                 IPI:IPI00013508.5 
                 LAILGIHNEVSK 
                 1.17 
                 0.70 
                 1.68 
               
               
                   
                 actinin-1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ACTN1 
                 Alpha- 
                 IPI:IPI00013508.5 
                 VGWEQLLTTIAR 
                 1.50 
                 1.32 
                 1.13 
               
               
                   
                 actinin-1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ADAMTSL2 
                 ADAMTS-like 
                 IPI:IPI00644346.2 
                 NFNIAGTVVK 
                 0.68 
                 0.55 
                 1.23 
               
               
                   
                 protein 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 AGT 
                 Angiotensinogen 
                 IPI:IPI00032220.3 
                 STLAFNTYVHFQGK 
                 1.61 
                   
                   
               
               
                   
               
               
                 AGT 
                 Angiotensinogen 
                 IPI:IPI00032220.3 
                 VGEVLNSIFFELEADER 
                   
                 0.26 
                   
               
               
                   
               
               
                 AHSG 
                 Alpha-2-HS- 
                 IPI:IPI00022431.1 
                 FSVVYAK 
                 80.04 
                 123.13 
                 0.65 
               
               
                   
                 glycoprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 AEFAEVSK 
                 3.86 
                 0.16 
                 23.74 
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 AVMDDFAAFVEK 
                 26.36 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 DVFLGMFLYEYAR 
                 6.14 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 FKDLGEENFK 
                 19.32 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 FQNALLVR 
                 18.06 
                 0.09 
                 209.25 
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 KQTALVELVK 
                 6.23 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 KYLYEIAR 
                 2.08 
                 2.41 
                 0.86 
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 LVAASQAALGL 
                 6.02 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 LVNEVTEFAK 
                 25.15 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 LVTDLTK 
                 5.31 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 QNCELFEQLGEYK 
                   
                 1.14 
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 RHPYFYAPELLFFAK 
                 4.53 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 TYETTLEK 
                 5.97 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 VFDEFKPLVEEPQNLIK 
                 19.11 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 VPQVSTPTLVEVSR 
                 1.26 
                   
                   
               
               
                   
               
               
                 ALB 
                 Serum albumin 
                 IPI:IPI00745872.2 
                 YLYEIAR 
                 7.48 
                   
                   
               
               
                   
               
               
                 ALDH3A1 
                 Aldehyde 
                 IPI:IPI00296183.7 
                 FMNSGQTCVAPDYILCDPSI 
                 0.46 
                   
                   
               
               
                   
                 dehydrogenase, 
                   
                 QNQIVEKLKK 
                   
                   
                   
               
               
                   
                 dimeric NADP- 
                   
                   
                   
                   
                   
               
               
                   
                 preferring 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 AMBP 
                 AMBP protein 
                 IPI:IPI00022426.1 
                 AFIQLWAFDAVK 
                 26.03 
                 45.43 
                 0.57 
               
               
                   
               
               
                 AMBP 
                 AMBP protein 
                 IPI:IPI00022426.1 
                 TVAACNLPIVR 
                 2.78 
                 7.69 
                 0.36 
               
               
                   
                 Isoform 2 of 
                   
                   
                   
                   
                   
               
               
                   
                 Ankyrin repeat 
                   
                   
                   
                   
                   
               
               
                   
                 domain- 
                   
                   
                   
                   
                   
               
               
                   
                 containing 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ANKRD6 
                 protein 6 
                 IPI:IPI00218274.1 
                 KRERLK 
                   
                 0.06 
                   
               
               
                   
               
               
                 ANPEP 
                 Aminopeptidase 
                 IPI:IPI00221224.6 
                 ALEQALEK 
                 0.21 
                 0.53 
                 0.40 
               
               
                   
                 N 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 AKPALEDLR 
                 40.63 
                 61.64 
                 0.66 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 FLSALEEYTK 
                 0.67 
                 0.46 
                 1.46 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 LHELQEKLSPLGEEMRDR 
                 0.99 
                 1.38 
                 0.72 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 QKVEPLR 
                 5.27 
                 4.80 
                 1.10 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 QKVEPLRAELQEGAR 
                 4.64 
                 5.86 
                 0.79 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 VEPLRAELQEGAR 
                 4.87 
                 5.23 
                 0.93 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 VQPYLDDFQKK 
                 13.44 
                 32.60 
                 0.41 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA1 
                 Apolipoprotein 
                 IPI:IPI00021841.1 
                 VSFLSALEEYTK 
                 49.59 
                 71.41 
                 0.69 
               
               
                   
                 A-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA4 
                 Apolipoprotein 
                 IPI:IPI00304273.2 
                 DSEKLKEEIGK 
                   
                 0.17 
                   
               
               
                   
                 A-IV 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA4 
                 Apolipoprotein 
                 IPI:IPI00304273.2 
                 ISASAEELRQR 
                 0.29 
                 0.81 
                 0.35 
               
               
                   
                 A-IV 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA4 
                 Apolipoprotein 
                 IPI:IPI00304273.2 
                 QLTPYAQR 
                 2.50 
                 2.92 
                 0.86 
               
               
                   
                 A-IV 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA4 
                 Apolipoprotein 
                 IPI:IPI00304273.2 
                 RRVEPYGENFNK 
                   
                 0.22 
                   
               
               
                   
                 A-IV 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOA4 
                 Apolipoprotein 
                 IPI:IPI00304273.2 
                 VEPYGENFNK 
                 0.48 
                 0.47 
                 1.01 
               
               
                   
                 A-IV 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 ALYWVNGQVPDGVSK 
                 0.79 
                 0.47 
                 1.69 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 DKIGVELTGR 
                 5.81 
                   
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 EEEAASGLLTSLKDNVPK 
                 0.38 
                   
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 ENFAGEATLQR 
                 18.65 
                 17.01 
                 1.10 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 ESVKFSSK 
                 0.14 
                   
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 HIYAISSAALSASYK 
                 1.39 
                 0.64 
                 2.17 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 NIQEYLSILTDPDGKGKEK 
                 1.29 
                 6.98 
                 0.19 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 QIDDIDVR 
                 8.19 
                 10.09 
                 0.81 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 SKEVPEAR 
                 0.18 
                 0.17 
                 1.07 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 SKPTVSSSMEFK 
                   
                 0.16 
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 TEHGSEMLFFGNAIEGK 
                 0.13 
                 0.46 
                 0.27 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 TLQGIPQMIGEVIRK 
                 1.09 
                 0.81 
                 1.35 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 VLVDHFGYTKDDKHEQDM 
                 0.80 
                 0.31 
                 2.56 
               
               
                   
                 B-100 
                   
                 VNGIMLSVEK 
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 VRESDEETQIK 
                 0.07 
                 0.19 
                 0.36 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 YEVDQQIQVLMDK 
                   
                 0.16 
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 YKNFATSNK 
                 1.22 
                 1.01 
                 1.20 
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOB 
                 Apolipoprotein 
                 IPI:IPI00022229.1 
                 YLRTEHGSEMLFFGNAIEGK 
                   
                 0.92 
                   
               
               
                   
                 B-100 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOC1 
                 Apolipoprotein 
                 IPI:IPI00021855.1 
                 EWFSETFQK 
                 3.00 
                 0.10 
                 30.94 
               
               
                   
                 C-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOC1 
                 Apolipoprotein 
                 IPI:IPI00021855.1 
                 LKEFGNTLEDK 
                 7.68 
                 0.30 
                 25.40 
               
               
                   
                 C-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOC1 
                 Apolipoprotein 
                 IPI:IPI00021855.1 
                 MREWFSETFQK 
                 3.08 
                 0.38 
                 8.18 
               
               
                   
                 C-I 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOC1 
                 Apolipoprotein 
                 IPI:IPI00021855.1 
                 TPDVSSALDKLKEFGNTLED 
                 1.13 
                   
                   
               
               
                   
                 C-I 
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 APOC2 
                 Apolipoprotein 
                 IPI:IPI00021856.3 
                 TAAQNLYEK 
                 5.43 
                 2.86 
                 1.90 
               
               
                   
                 C-II 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOC3 
                 Apolipoprotein 
                 IPI:IPI00021857.1 
                 SEAEDASLLSFMQGYMK 
                 1.02 
                   
                   
               
               
                   
                 C-III 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 FWDYLR 
                 3.08 
                 0.96 
                 3.22 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 GEVQAMLGQSTEELR 
                 8.71 
                 3.56 
                 2.45 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 LEEQAQQIR 
                 0.55 
                 0.12 
                 4.78 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 LKSWFEPLVEDMQR 
                 0.77 
                 0.44 
                 1.76 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 MEEMGSR 
                 0.29 
                 0.11 
                 2.70 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 QWAGLVEK 
                 2.11 
                 0.77 
                 2.74 
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 RLAVYQAGAR 
                 0.21 
                   
                   
               
               
                   
               
               
                 APOE 
                 Apolipoprotein E 
                 IPI:IPI00021842.1 
                 WVQTLSEQVQEELLSSQVT 
                 6.49 
                 2.16 
                 3.01 
               
               
                   
                   
                   
                 QELR 
                   
                   
                   
               
               
                   
               
               
                 APOF 
                 apolipoprotein F 
                 IPI:IPI00299435.3 
                 SGVQQLIQYYQDQK 
                 1.79 
                   
                   
               
               
                   
               
               
                 APOH 
                 Beta-2- 
                 IPI:IPI00298828.3 
                 ATVVYQGER 
                 31.67 
                 42.04 
                 0.75 
               
               
                   
                 glycoprotein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOH 
                 Beta-2- 
                 IPI:IPI00298828.3 
                 EHSSLAFWK 
                 27.55 
                 40.14 
                 0.69 
               
               
                   
                 glycoprotein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOH 
                 Beta-2- 
                 IPI:IPI00298828.3 
                 TCPKPDDLPFSTVVPLK 
                 0.34 
                 0.75 
                 0.45 
               
               
                   
                 glycoprotein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 APOL1 
                 42 kDa protein 
                 IPI:IPI00852826.2 
                 NWFLKEFPR 
                 1.00 
                 0.38 
                 2.59 
               
               
                   
               
               
                 APOM 
                 Apolipoprotein M 
                 IPI:IPI00030739.1 
                 AFLLTPR 
                 2.31 
                 1.34 
                 1.72 
               
               
                   
               
               
                 APOM 
                 Apolipoprotein M 
                 IPI:IPI00030739.1 
                 FLLYNR 
                 2.37 
                 1.73 
                 1.37 
               
               
                   
               
               
                 APOM 
                 Apolipoprotein M 
                 IPI:IPI00030739.1 
                 KWIYHLTEGSTDLR 
                 0.24 
                   
                   
               
               
                   
               
               
                 ARHGDIB 
                 Rho GDP-dissociation 
                 IPI:IPI00003817.3 
                 ETIVLKEGSEYR 
                   
                 4.62 
                   
               
               
                   
                 inhibitor 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ARHGDIB 
                 Rho GDP-dissociation 
                 IPI:IPI00003817.3 
                 TLLGDGPVVTDPK 
                 0.33 
                   
                   
               
               
                   
                 inhibitor 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ARNTL 
                 Isoform MOP3 of Aryl 
                 IPI:IPI00217736.1 
                 EMTGSGRR 
                   
                 0.21 
                   
               
               
                   
                 hydrocarbon receptor 
                   
                   
                   
                   
                   
               
               
                   
                 nuclear translocator- 
                   
                   
                   
                   
                   
               
               
                   
                 like protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ASL 
                 Argininosuccinate  
                 IPI:IPI00220267.7 
                 ALLQAQQA 
                 0.39 
                 0.61 
                 0.64 
               
               
                   
                 lyase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 AZGP1 
                 alpha-2- 
                 IPI:IPI00166729.4 
                 AGEVQEPELR 
                 11.94 
                 16.22 
                 0.74 
               
               
                   
                 glycoprotein 1, zinc 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 AZGP1 
                 alpha-2- 
                 IPI:IPI00166729.4 
                 HVEDVPAFQALGSLNDLQF 
                 19.92 
                 31.15 
                 0.64 
               
               
                   
                 glycoprotein 1, zinc 
                   
                 FR 
                   
                   
                   
               
               
                   
               
               
                 AZGP1 
                 alpha-2- 
                 IPI:IPI00166729.4 
                 IDVHWTR 
                 15.39 
                 23.89 
                 0.64 
               
               
                   
                 glycoprotein 1, zinc 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 AZGP1 
                 alpha-2- 
                 IPI:IPI00166729.4 
                 YSLTYIYTGLSK 
                 22.15 
                 34.77 
                 0.64 
               
               
                   
                 glycoprotein 1, zinc 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 B2M 
                 Beta-2-microglobulin 
                 IPI:IPI00868938.1 
                 IEKVEHSDLSFSK 
                   
                 2.38 
                   
               
               
                   
               
               
                 B2M 
                 Beta-2-microglobulin 
                 IPI:IPI00868938.1 
                 IQVYSR 
                 0.75 
                 3.60 
                 0.21 
               
               
                   
               
               
                 BCHE 
                 Cholinesterase 
                 IPI:IPI00025864.5 
                 DNNSIITR 
                 7.68 
                 9.51 
                 0.81 
               
               
                   
               
               
                 BCHE 
                 Cholinesterase 
                 IPI:IPI00025864.5 
                 WNNYMMDWK 
                   
                 0.35 
                   
               
               
                   
               
               
                 BHMT 
                 Betaine--homocysteine  
                 IPI:IPI00004101.4 
                 AGPWTPEAAVEHPEAVR 
                 1.72 
                   
                   
               
               
                   
                 S-methyltransferase 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 BLVRB 
                 Flavin reductase 
                 IPI:IPI00783862.2 
                 HDLGHFMLR 
                 0.28 
                   
                   
               
               
                   
               
               
                 BRUNOL4 
                 LYST-interacting  
                 IPI:IPI00386504.1 
                 MAALNMIWAGSRTYDPNLR 
                 0.51 
                   
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
                 LIP9 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 BRWD1 
                 Isoform B of 
                 IPI:IPI00250716.1 
                 ASAVAR 
                 19.37 
                   
                   
               
               
                   
                 Bromodomain and WD 
                   
                   
                   
                   
                   
               
               
                   
                 repeat-containing  
                   
                   
                   
                   
                   
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 BTD 
                 biotinidase 
                 IPI:IPI00218413.2 
                 QEALELMNQNLDIYEQQVM 
                 0.33 
                 0.56 
                 0.59 
               
               
                   
                   
                   
                 TAAQK 
                   
                   
                   
               
               
                   
               
               
                 C1QA 
                 Complement C1q 
                 IPI:IPI00022392.1 
                 SLGFCDTTNK 
                 1.32 
                 1.28 
                 1.03 
               
               
                   
                 subcomponent subunit A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1QB 
                 complement component 1, 
                 IPI:IPI00477992.1 
                 DQTIRFDHVITNMNNNYEPR 
                   
                 0.66 
                   
               
               
                   
                 q subcomponent, B chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1R 
                 Complement C1r 
                 IPI:IPI00296165.5  
                 YTTEIIK 
                 4.66 
                 6.69 
                 0.70 
               
               
                   
                 subcomponent 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1R; 
                 Complement C1r 
                 IPI:IPI00296165.5 
                 EFMSQGNK 
                 0.59 
                 0.85 
                 0.69 
               
               
                 C17orf1 
                 subcomponent 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1RL 
                 Complement C1r-like 
                 IPI:IPI00009793.3 
                 GSEAINAPGDNPAK 
                 0.42 
                 0.43 
                 0.98 
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1RL 
                 Complement C1r-like 
                 IPI:IPI00009793.3 
                 LGNFPWQAFTSIHGR 
                 0.13 
                   
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1S 
                 Complement C1s 
                 IPI:IPI00017696.1 
                 EVKVEKPTADAEAYVFTPN 
                 6.25 
                 9.93 
                 0.63 
               
               
                   
                 subcomponent 
                   
                 MICAGGEKG 
                   
                   
                   
               
               
                   
               
               
                 C1S 
                 Complement C1s 
                 IPI:IPI00017696.1 
                 IIGGSDADIK 
                 2.17 
                   
                   
               
               
                   
                 subcomponent 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1S 
                 Complement C1s 
                 IPI:IPI00017696.1 
                 TNFDNDIALVR 
                 5.26 
                 6.98 
                 0.75 
               
               
                   
                 subcomponent 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C1S 
                 Complement C1s 
                 IPI:IPI00017696.1 
                 VKNYVDWIMK 
                 0.50 
                 1.73 
                 0.29 
               
               
                   
                 subcomponent 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C2 
                 Complement C2 
                 IPI:IPI00303963.1 
                 SSGQWQTPGATR 
                 0.45 
                 0.63 
                 0.71 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C2 
                 Complement C2 
                 IPI:IPI00303963.1 
                 TPWHVTIKPK 
                 0.31 
                   
                   
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 APSTWLTAYVVK 
                 45.19 
                 52.79 
                 0.86 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 DQLTCNKFDLK 
                 0.28 
                 0.49 
                 0.58 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 DSCVGSLVVK 
                 5.38 
                 7.71 
                 0.70 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 EALKLEEK 
                 39.64 
                 49.25 
                 0.80 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 ETKENEGFTVTAEGK 
                 0.12 
                 0.08 
                 1.55 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 EYVLPSFEVIVEPTEKFYYIY 
                   
                 7.25 
                   
               
               
                   
                 (Fragment) 
                   
                 NEK 
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 GQGTLSVVTMYHAK 
                 71.12 
                 89.56 
                 0.79 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 IEGDHGAR 
                 0.31 
                 0.69 
                 0.45 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 ILLQGTPVAQMTEDAVDAE 
                 6.56 
                 31.38 
                 0.21 
               
               
                   
                 (Fragment) 
                   
                 RLK 
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 PESWLWNVEDLKEPPK 
                 0.14 
                   
                   
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 PPADLSDQVPDTESETR 
                 0.18 
                   
                   
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 PYVIVPLKTGLQEVEVK 
                 0.68 
                 1.71 
                 0.40 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 SGSDEVQVGQQR 
                 39.75 
                 46.61 
                 0.85 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 SINTHPSQKPLSITVR 
                 0.20 
                   
                   
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 VLLDGVQNPR 
                 83.31 
                 104.55 
                 0.80 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C3 
                 Complement C3 
                 IPI:IPI00783987.2 
                 VVLVSLQSGYLFIQTDK 
                 4.92 
                 5.73 
                 0.86 
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 GQIVFMNREPK 
                 11.87 
                 5.23 
                 2.27 
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 GSGATFSHYYYMILSR 
                 0.52 
                   
                   
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 HLVPGAPFLLQALVR 
                 15.53 
                 5.25 
                 2.95 
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 LGQYASPTAKR 
                 0.17 
                 0.26 
                 0.64 
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 LNMGITDLQGLR 
                 72.56 
                 46.19 
                 1.57 
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 LVNGQSHISLSK 
                 0.48 
                 0.55 
                 0.87 
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 PNMIPDGDFNSYVR 
                 0.43 
                   
                   
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 SMQGGLVGNDETVALTAFV 
                 0.40 
                 0.13 
                 3.05 
               
               
                   
                 4A 
                   
                 TIALHHGLAVFQDEGAEPLK 
                   
                   
                   
               
               
                   
                   
                   
                 QR 
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 SPSVVHLGVPLSVGVQLQD 
                 0.45 
                 0.70 
                 0.64 
               
               
                   
                 4A 
                   
                 VPR 
                   
                   
                   
               
               
                   
               
               
                 C4A 
                 Complement component 
                 IPI:IPI00643525.1 
                 TITVMVENSHGLR 
                   
                 0.29 
                   
               
               
                   
                 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 GQIVFMNREPK 
                 11.87 
                 5.23 
                 2.27 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 GSGATFSHYYYMILSR 
                 0.52 
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 HLVPGAPFLLQALVR 
                 15.53 
                 5.25 
                 2.95 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 LGQYASPTAKR 
                 0.17 
                 0.26 
                 0.64 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 LNMGITDLQGLR 
                 72.56 
                 46.19 
                 1.57 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 LQETSNWLLSQQQADGSFQ 
                 30.40 
                 17.38 
                 1.75 
               
               
                   
                   
                   
                 DLSPVIHR 
                   
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 LVNGQSHISLSK 
                 0.48 
                 0.55 
                 0.87 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 PNMIPDGDFNSYVR 
                 0.43 
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 PVAFSVVPTAATAVSLK 
                 1.05 
                 7.66 
                 0.14 
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 SMQGGLVGNDETVALTAFV 
                 0.40 
                 0.13 
                 3.05 
               
               
                   
                   
                   
                 TIALHHGLAVFQDEGAEPLK 
                   
                   
                   
               
               
                   
                   
                   
                 QR 
                   
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 SPSVVHLGVPLSVGVQLQD 
                 0.45 
                 0.70 
                 0.64 
               
               
                   
                   
                   
                 VPR 
                   
                   
                   
               
               
                   
               
               
                 C4B 
                 C4B1 
                 IPI:IPI00418163.3 
                 TITVMVENSHGLR 
                   
                 0.29 
                   
               
               
                   
               
               
                 C4BPA 
                 C4b-binding protein  
                 IPI:IPI00021727.1 
                 GVGWSHPLPQCEIVK 
                   
                 0.29 
                   
               
               
                   
                 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 ATLLDIYK 
                 5.86 
                 7.64 
                 0.77 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 DSLDQLVGGVPVTLNAQTI 
                 3.49 
                 4.51 
                 0.77 
               
               
                   
                   
                   
                 DVNQETSDLDPSK 
                   
                   
                   
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 EALQIK 
                 0.40 
                 0.45 
                 0.89 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 ETVLTFIDPEGSEVDMVEEI 
                 8.40 
                 10.50 
                 0.80 
               
               
                   
                   
                   
                 DHIGIISFPDFK 
                   
                   
                   
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 IDTQDIEASHYR 
                 4.23 
                 6.45 
                 0.66 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 KIEEIAAK 
                 3.68 
                 5.19 
                 0.71 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 LKEGMLSIMSYR 
                 2.26 
                 3.67 
                 0.62 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 LQGTLPVEAR 
                 14.02 
                 18.08 
                 0.78 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 MVETTAYALLTSLNLKDINY 
                 0.47 
                 4.22 
                 0.11 
               
               
                   
                   
                   
                 VNPVIK 
                   
                   
                   
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 NFEITIK 
                 4.50 
                 6.52 
                 0.69 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 QLPGGQNPVSYVYLEVVSK 
                 1.15 
                 1.61 
                 0.72 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 QYLIMGK 
                 2.80 
                 3.67 
                 0.76 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 TDAPDLPEENQAR 
                 2.67 
                 4.11 
                 0.65 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 TLLPVSKPEIR 
                 17.92 
                 23.93 
                 0.75 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 VFQFLEK 
                 10.48 
                 15.04 
                 0.70 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 VQVKDSLDQLVGGVPVTLN 
                   
                 1.18 
                   
               
               
                   
                   
                   
                 AQTIDVNQETSDLDPSK 
                   
                   
                   
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 VVPEGVKR 
                 2.62 
                 3.94 
                 0.67 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 WLSEEQR 
                 3.06 
                 4.30 
                 0.71 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 YGMWTIK 
                 3.29 
                 4.61 
                 0.71 
               
               
                   
               
               
                 C5 
                 Complement C5 
                 IPI:IPI00032291.2 
                 YNFSFR 
                 3.90 
                 5.57 
                 0.70 
               
               
                   
               
               
                 C6 
                 Complement component 6 
                 IPI:IPI00009920.2 
                 IGESIELTCPK 
                 7.46 
                 6.33 
                 1.18 
               
               
                   
               
               
                 C6 
                 Complement component 6 
                 IPI:IPI00009920.2 
                 LSEKHEGSFIQGAEK 
                 0.56 
                 0.81 
                 0.70 
               
               
                   
               
               
                 C7 
                 Complement component 
                 IPI:IPI00296608.6 
                 AASGTQNNVLRGEPFIR 
                   
                 0.18 
                   
               
               
                   
                 C7 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C7 
                 Complement component 
                 IPI:IPI00296608.6 
                 GGGAGFISGLSYLELDNPAG 
                 1.10 
                 1.41 
                 0.78 
               
               
                   
                 C7 
                   
                 NK 
                   
                   
                   
               
               
                   
               
               
                 C7 
                 Complement component 
                 IPI:IPI00296608.6 
                 VLFYVDSEKLK 
                 0.49 
                 0.90 
                 0.55 
               
               
                   
                 C7 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C8A 
                 Complement component 
                 IPI:IPI00011252.1 
                 SLLQPNK 
                 6.84 
                 9.99 
                 0.68 
               
               
                   
                 C8 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C8A 
                 Complement component 
                 IPI:IPI00011252.1 
                 YNPVVIDFEMQPIHEVLR 
                 1.61 
                 1.47 
                 1.09 
               
               
                   
                 C8 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C8B 
                 Complement component 
                 IPI:IPI00294395.1 
                 GGASEHITTLAYQELPTADL 
                 2.13 
                 1.76 
                 1.21 
               
               
                   
                 C8 beta chain 
                   
                 MQEWGDAVQYNPAIIK 
                   
                   
                   
               
               
                   
               
               
                 C9 
                 Complement component 
                 IPI:IPI00022395.1 
                 KGVELK 
                 0.12 
                   
                   
               
               
                   
                 C9 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 C9 
                 Complement component 
                 IPI:IPI00022395.1 
                 TEHYEEQIEAFK 
                 11.87 
                 9.19 
                 1.29 
               
               
                   
                 C9 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CA1 
                 Carbonic anhydrase 1 
                 IPI:IPI00215983.3 
                 GGPFSDSYR 
                 0.94 
                   
                   
               
               
                   
               
               
                 CA1 
                 Carbonic anhydrase 1 
                 IPI:IPI00215983.3 
                 HDTSLKPISVSYNPATAK 
                 2.31 
                   
                   
               
               
                   
               
               
                 CAl 
                 Carbonic anhydrase 1 
                 IPI:IPI00215983.3 
                 SLLSNVEGDNAVPMQHNNR 
                 2.88 
                   
                   
               
               
                   
                   
                   
                 PTQPLK 
                   
                   
                   
               
               
                   
               
               
                 CACNA2D1 
                 Dihydropyridine receptor 
                 IPI:IPI00470535.1 
                 TPNKIDLYDVR 
                 1.41 
                 0.51 
                 2.74 
               
               
                   
                 alpha 2 subunit 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CCDC89 
                 Coiled-coil domain- 
                 IPI:IPI00167663.1 
                 ERELNGK 
                 10.66 
                 14.27 
                 0.75 
               
               
                   
                 containing protein 89 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 AFPALTSLDLSDNPGLGER 
                 0.53 
                 0.46 
                 1.14 
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 ATVNPSAPR 
                 0.36 
                 0.21 
                 1.73 
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 FPAIQNLALR 
                 0.37 
                 0.34 
                 1.11 
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 ITGTMPPLPLEATGLALSSLR 
                 0.65 
                 0.29 
                 2.29 
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 LTVGAAQVPAQLLVGALR 
                 0.38 
                 0.31 
                 1.25 
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CD14 
                 Monocyte differentiation 
                 IPI:IPI00029260.2 
                 SWLAELQQWLKPGLK 
                 0.33 
                   
                   
               
               
                   
                 antigen CD14 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CDH5 
                 Cadherin-5 
                 IPI:IPI00012792.1 
                 VHDVNDNWPVFTHR 
                 0.52 
                   
                   
               
               
                   
               
               
                 CDKL1 
                 cyclin-dependent kinase- 
                 IPI:IPI00023527.5 
                 SDVDQLYLIR 
                   
                 0.37 
                   
               
               
                   
                 like 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CECR1 
                 Cat eye syndrome  
                 IPI:IPI00303071.4 
                 WILLEDYRK 
                   
                 0.35 
                   
               
               
                   
                 critical region  
                   
                   
                   
                   
                   
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CEP110 
                 Centrosomal protein 
                 IPI:IPI00376383.2 
                 AELEKER 
                 0.06 
                 0.12 
                 0.52 
               
               
                   
                 110 kDa 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CES1 
                 Isoform 1 of Liver 
                 IPI:IPI00010180.4 
                 QEFGWLIPMQLMSYPLSEG 
                 0.66 
                   
                   
               
               
                   
                 carboxylesterase 1 
                   
                 QLDQK 
                   
                   
                   
               
               
                   
               
               
                 CFB 
                 Isoform 1 of Complement 
                 IPI:IPI00019591.1 
                 LEDSVTYHCSR 
                 0.38 
                 0.38 
                 0.98 
               
               
                   
                 factor B (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CFB 
                 Isoform 1 of Complement 
                 IPI:IPI00019591.1 
                 LQDEDLGFL 
                 17.49 
                 20.39 
                 0.86 
               
               
                   
                 factor B (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CFB 
                 Isoform 1 of Complement 
                 IPI:IPI00019591.1 
                 QLNEINYEDHKLK 
                 0.35 
                 2.99 
                 0.12 
               
               
                   
                 factor B (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CFD 
                 Complement factor D 
                 IPI:IPI00165972.3 
                 LYDVLR 
                   
                 0.48 
                   
               
               
                   
                 preproprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CFH 
                 Isoform 1 of Complement 
                 IPI:IPI00029739.5 
                 IDVHLVPDR 
                 33.22 
                 40.39 
                 0.82 
               
               
                   
                 factor H 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CFI 
                 Complement factor I 
                 IPI:IPI00291867.3 
                 IVIEYVDR 
                 7.42 
                 9.34 
                 0.79 
               
               
                   
               
               
                 CFI 
                 Complement factor I 
                 IPI:IPI00291867.3 
                 TMFICK 
                 0.50 
                   
                   
               
               
                   
               
               
                 CFI 
                 Complement factor I 
                 IPI:IPI00291867.3 
                 VANYFDWISYHVGR 
                 0.21 
                 0.36 
                 0.57 
               
               
                   
               
               
                 CFL1 
                 Cofilin-1 
                 IPI:IPI00012011.6 
                 EILVGDVGQTVDDPYATFV 
                 0.21 
                   
                   
               
               
                   
                   
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 CHIT1 
                 Isoform 3 of 
                 IPI:IPI00375364.1 
                 FTTLVQDLANAFQQEAQTS 
                 3.66 
                 1.77 
                 2.07 
               
               
                   
                 Chitotriosidase-1 
                   
                 GK 
                   
                   
                   
               
               
                   
               
               
                 CLEC3B 
                 Tetranectin 
                 IPI:IPI00009028.1 
                 KDVVNTK 
                 0.03 
                 0.08 
                 0.42 
               
               
                   
               
               
                 CLEC3B 
                 Tetranectin 
                 IPI:IPI00009028.1 
                 LDTLAQEVALLK 
                 3.37 
                 5.17 
                 0.65 
               
               
                   
               
               
                 CLEC3B 
                 Tetranectin 
                 IPI:IPI00009028.1 
                 MFEELK 
                 0.19 
                 0.23 
                 0.85 
               
               
                   
               
               
                 CLEC3B 
                 Tetranectin 
                 IPI:IPI00009028.1 
                 SRLDTLAQEVALLK 
                 0.66 
                 1.07 
                 0.61 
               
               
                   
               
               
                 CNDP1 
                 Beta-Ala-His dipeptidase 
                 IPI:IPI00064667.4 
                 DGSTIPIAK 
                 0.41 
                 0.27 
                 1.52 
               
               
                   
               
               
                 CNDP1 
                 Beta-Ala-His dipeptidase 
                 IPI:IPI00064667.4 
                 HLEDVFSKR 
                   
                 0.16 
                   
               
               
                   
               
               
                 CNDP1 
                 Beta-Ala-His dipeptidase 
                 IPI:IPI00064667.4 
                 MFQEIVHK 
                   
                 0.20 
                   
               
               
                   
               
               
                 CNTN1 
                 Isoform 1 of  
                 IPI:IPI00029751.1 
                 YVHKDETMSPSTAFQVK 
                 0.30 
                   
                   
               
               
                   
                 Contactin-1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 COL1A2 
                 Collagen alpha-2(I)  
                 IPI:IPI00304962.3 
                 DYEVDATLK 
                 0.19 
                 0.30 
                 0.63 
               
               
                   
                 chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 COL6A3 
                 alpha 3 type VI  
                 IPI:IPI00022200.2 
                 SDDEVDDPAVELK 
                 0.17 
                 46.32 
                 0.00 
               
               
                   
                 collagen isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CP 
                 Ceruloplasmin 
                 IPI:IPI00017601.1 
                 EVGPTNADPVCLAK 
                 8.29 
                 11.01 
                 0.75 
               
               
                   
               
               
                 CP 
                 Ceruloplasmin 
                 IPI:IPI00017601.1 
                 KLISVDTEHSNIYLQNGPDR 
                 9.19 
                 8.60 
                 1.07 
               
               
                   
               
               
                 CP 
                 Ceruloplasmin 
                 IPI:IPI00017601.1 
                 PDQVDKEDEDFQESNK 
                 0.26 
                 0.44 
                 0.59 
               
               
                   
               
               
                 CP 
                 Ceruloplasmin 
                 IPI:IPI00017601.1 
                 PVWLGFLGPIIK 
                 0.31 
                 0.37 
                 0.85 
               
               
                   
               
               
                 CPB2 
                 Isoform 1 of 
                 IPI:IPI00329775.7 
                 YSFTIELR 
                 0.63 
                 0.34 
                 1.83 
               
               
                   
                 Carboxypeptidase B2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CPN1 
                 Carboxypeptidase N 
                 IPI:IPI00010295.1 
                 IVQLIQDTR 
                 2.44 
                 3.28 
                 0.74 
               
               
                   
                 catalytic chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CPN1 
                 Carboxypeptidase N 
                 IPI:IPI00010295.1 
                 TASTPTPDDKLFQK 
                 0.38 
                 0.42 
                 0.90 
               
               
                   
                 catalytic chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CPN2 
                 similar to 
                 IPI:IPI00738433.1 
                 AGGSWDLAVQER 
                 0.99 
                 1.29 
                 0.77 
               
               
                   
                 Carboxypeptidase N 
                   
                   
                   
                   
                   
               
               
                   
                 subunit 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CPN2 
                 similar to 
                 IPI:IPI00738433.1 
                 LSNNALSGLPQGVFGK 
                 2.44 
                 3.86 
                 0.63 
               
               
                   
                 Carboxypeptidase N 
                   
                   
                   
                   
                   
               
               
                   
                 subunit 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CR2 
                 Isoform B of Complement 
                 IPI:IPI00216985.1 
                 CVIAGQGVAWTK 
                 0.80 
                   
                   
               
               
                   
                 receptor type 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 AFVFPK 
                 7.08 
                 4.75 
                 1.49 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 APLTKPLK 
                 15.53 
                 5.33 
                 2.92 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 ESDTSYVSLK 
                 27.67 
                 7.66 
                 3.61 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 GYSIFSYATK 
                 23.94 
                 12.45 
                 1.92 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 KAFVFPK 
                 24.11 
                 5.76 
                 4.19 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 QDNEILIFWSK 
                 3.60 
                 3.94 
                 0.91 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 RQDNEILIFWSK 
                 24.62 
                 17.36 
                 1.42 
               
               
                   
               
               
                 CRP 
                 C-reactive protein 
                 IPI:IPI00022389.1 
                 YEVQGEVFTKPQLWP 
                 19.78 
                 11.80 
                 1.68 
               
               
                   
               
               
                 CRYZ 
                 Quinone oxidoreductase 
                 IPI:IPI00000792.1 
                 VFEFGGPEVLK 
                 0.56 
                   
                   
               
               
                   
               
               
                 CST3 
                 Cystatin-C 
                 IPI:IPI00032293.1 
                 ASNDMYHSR 
                   
                 0.25 
                   
               
               
                   
               
               
                 CST3 
                 Cystatin-C 
                 IPI:IPI00032293.1 
                 LVGGPMDASVEEEGVRR 
                   
                 1.32 
                   
               
               
                   
               
               
                 CTSA 
                 cathepsin A 
                 IPI:IPI00640525.2 
                 YGDSGEQIAGFVK 
                   
                 0.33 
                   
               
               
                   
               
               
                 CTSB 
                 Cathepsin B 
                 IPI:IPI00295741.4 
                 SGVYQHVTGEMMGGHAIR 
                 1.34 
                 2.07 
                 0.65 
               
               
                   
               
               
                 CUL4A 
                 Isoform 1 of Cullin-4A 
                 IPI:IPI00419273.5 
                 RIESLIDR 
                 4.35 
                 6.76 
                 0.64 
               
               
                   
               
               
                 DKK3 
                 Dickkopf-related  
                 IPI:IPI00002714.1 
                 LLDLITWELEPDGALDR 
                   
                 13.43 
                   
               
               
                   
                 protein 3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 DSTN 
                 Destrin 
                 IPI:IPI00473014.5 
                 MIYASSK 
                 0.54 
                 0.25 
                 2.21 
               
               
                   
               
               
                 ECM1 
                 Extracellular matrix 
                 IPI:IPI00645849.1 
                 NLPATDPLQR 
                 0.51 
                 0.77 
                 0.67 
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 EFEMP1 
                 Isoform 1 of EGF- 
                 IPI:IPI00029658.1 
                 QTSPVSAMLVLVK 
                 0.15 
                 0.46 
                 0.34 
               
               
                   
                 containing fibulin-like 
                   
                   
                   
                   
                   
               
               
                   
                 extracellular matrix  
                   
                   
                   
                   
                   
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ERAP1 
                 Isoform 2 of  
                 IPI:IPI00165949.2 
                 DMNEVETQFK 
                   
                 0.18 
                   
               
               
                   
                 Endoplasmic reticulum  
                   
                   
                   
                   
                   
               
               
                   
                 aminopeptidase 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ERC1 
                 Isoform 2 of ELKS/RAB6- 
                 IPI:IPI00171230.6 
                 QTLNARDESIKK 
                   
                 0.28 
                   
               
               
                   
                 interacting/CAST family 
                   
                   
                   
                   
                   
               
               
                   
                 member 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 F10 
                 Coagulation factor X 
                 IPI:IPI00019576.1 
                 APACLPERDWAESTLMTQK 
                 0.62 
                   
                   
               
               
                   
               
               
                 F10 
                 Coagulation factor X 
                 IPI:IPI00019576.1 
                 MLEVPYVDR 
                 0.57 
                 1.48 
                 0.39 
               
               
                   
               
               
                 F11 
                 Isoform 1 of  
                 IPI:IPI00008556.1 
                 ERPGVYTNVVEYVDWILEK 
                   
                 0.14 
                   
               
               
                   
                 Coagulation 
                   
                   
                   
                   
                   
               
               
                   
                 factor XI 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 F11 
                 Isoform 1 of  
                 IPI:IPI00008556.1 
                 MAESGYDIALLK 
                 0.21 
                 0.45 
                 0.48 
               
               
                   
                 Coagulation 
                   
                   
                   
                   
                   
               
               
                   
                 factor XI 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 GQPSVLQVVNLPIVERPVCK 
                 0.42 
                 0.68 
                 0.62 
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 IVEGSDAEIGMSPWQVMLF 
                 12.26 
                 18.80 
                 0.65 
               
               
                   
                   
                   
                 R 
                   
                   
                   
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 SGIECQLWR 
                 0.24 
                 0.57 
                 0.42 
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 SLEDKTERELLESYIDGR 
                   
                 3.18 
                   
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 TATSEYQTFFNPR 
                 25.22 
                 36.62 
                 0.69 
               
               
                   
               
               
                 F2 
                 Prothrombin (Fragment) 
                 IPI:IPI00019568.1 
                 VIDQFGE 
                 19.63 
                 27.80 
                 0.71 
               
               
                   
               
               
                 F5 
                 Coagulation factor V 
                 IPI:IPI00022937.4 
                 ASEFLGYWEPR 
                   
                 0.10 
                   
               
               
                   
               
               
                 FAM71A 
                 Protein FAM71A 
                 IPI:IPI00217863.2 
                 YAPIFESDFIQITK 
                 0.39 
                 0.35 
                 1.12 
               
               
                   
               
               
                 FBXO32 
                 F-box only protein 32  
                 IPI:IPI00056487.1 
                 LDFSTAILDSR 
                   
                 0.16 
                   
               
               
                   
               
               
                 FCGBP 
                 IgGFc-binding protein 
                 IPI:IPI00242956.4 
                 LLFDGDAHLLMSIPSPFR 
                   
                 0.21 
                   
               
               
                   
               
               
                 FCGR3A 
                 Low affinity 
                 IPI:IPI00218834.9 
                 AVVFLEPQWYR 
                 0.41 
                   
                   
               
               
                   
                 immunoglobulin gamma Fc 
                   
                   
                   
                   
                   
               
               
                   
                 region receptor III-A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FCN3 
                 Isoform 1 of Ficolin-3 
                 IPI:IPI00293925.2 
                 FSEGTAGDSLSLHSGR 
                   
                 0.13 
                   
               
               
                   
               
               
                 FGA 
                 Isoform 1 of Fibrinogen 
                 IPI:IPI00021885.1 
                 MELERPGGNEITR 
                 14.64 
                 0.77 
                 19.07 
               
               
                   
                 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGA 
                 Isoform 1 of Fibrinogen 
                 IPI:IPI00021885.1 
                 MELERPGGNEITR 
                 0.46 
                 0.14 
                 3.35 
               
               
                   
                 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGA 
                 Isoform 1 of Fibrinogen 
                 IPI:IPI00021885.1 
                 NPSSAGSWNSGSSGPGSTG 
                 2.82 
                   
                   
               
               
                   
                 alpha chain 
                   
                 NR 
                   
                   
                   
               
               
                   
               
               
                 FGA 
                 Isoform 1 of Fibrinogen 
                 IPI:IPI00021885.1 
                 SRIEVLKR 
                 0.30 
                   
                   
               
               
                   
                 alpha chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGB 
                 Fibrinogen beta chain 
                 IPI:IPI00298497.3 
                 MGPTELLIEMEDWKGDK 
                   
                 0.40 
                   
               
               
                   
               
               
                 FGG 
                 Gamma-B of Fibrinogen 
                 IPI:IPI00021891.5 
                 HLISTQSAIPYALR 
                   
                 0.19 
                   
               
               
                   
                 gamma chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGG 
                 Gamma-B of Fibrinogen 
                 IPI:IPI00021891.5 
                 HLSPTGTTEFWLGNEK 
                   
                 0.22 
                   
               
               
                   
                 gamma chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGG 
                 Gamma-B of Fibrinogen 
                 IPI:IPI00021891.5 
                 KMLEEIMK 
                 0.37 
                   
                   
               
               
                   
                 gamma chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGG 
                 Gamma-B of Fibrinogen 
                 IPI:IPI00021891.5 
                 MIDAATLK 
                 1.23 
                   
                   
               
               
                   
                 gamma chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FGG 
                 Gamma-B of Fibrinogen 
                 IPI:IPI00021891.5 
                 MIDAATLK 
                 2.25 
                 0.76 
                 2.97 
               
               
                   
                 gamma chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLJ22662 
                 hypothetical protein 
                 IPI:IPI00016255.4 
                 KDPYSR 
                   
                 0.33 
                   
               
               
                   
                 LOC79887 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLJ45139 
                 CDNA FLJ45139 fis,  
                 IPI:IPI00418931.1 
                 TVSIPR 
                 62.56 
                 77.85 
                 0.80 
               
               
                   
                 clone BRAWH3039623 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 AFGPGLQGGSAGSPAR 
                 1.81 
                 1.08 
                 1.67 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 AYGPGIEPTGNMVK 
                 3.41 
                 0.56 
                 6.13 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 GKLDVQFSGLTK 
                 0.80 
                 0.40 
                 1.98 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 IANLQTDLSDGLR 
                 2.05 
                 1.14 
                 1.80 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 IQQNTFTR 
                 0.72 
                 0.56 
                 1.30 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 LIALLEVLSQK 
                 1.88 
                 1.57 
                 1.20 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 LPQLPITNFSR 
                 2.00 
                 1.55 
                 1.29 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 TGVAVNKPAEFTVDAK 
                 1.17 
                 0.45 
                 2.57 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 VDVGKDQEFTVK 
                 0.83 
                 0.46 
                 1.80 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 VTAQGPGLEPSGNIANK 
                 2.24 
                 1.02 
                 2.20 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNA 
                 filamin A, alpha  
                 IPI:IPI00302592.2 
                 VTVLFAGQHIAK 
                 0.95 
                 0.65 
                 1.46 
               
               
                   
                 isoform 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FLNB 
                 Isoform 1 of Filamin-B 
                 IPI:IPI00289334.1 
                 IQQNTFTR 
                 0.72 
                 0.56 
                 1.30 
               
               
                   
               
               
                 FLNB 
                 Isoform 1 of Filamin-B 
                 IPI:IPI00289334.1 
                 LIALLEVLSQK 
                 1.88 
                 1.57 
                 1.20 
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 GATYNIIVEALK 
                 0.41 
                   
                   
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 ITGYIIK 
                 0.58 
                   
                   
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 SYTITGLQPGTDYK 
                 0.38 
                   
                   
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 VGDTYERPK 
                 0.13 
                   
                   
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 VTWAPPPSIDLTNFLVR 
                 0.49 
                   
                   
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FN1 
                 Isoform 1 of  
                 IPI:IPI00022418.1 
                 YEKPGSPPR 
                 0.21 
                 0.04 
                 5.18 
               
               
                   
                 Fibronectin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 FTL 
                 Ferritin light chain 
                 IPI:IPI00738499.2 
                 LGGPEAGLGEYLFER 
                 2.66 
                   
                   
               
               
                   
               
               
                 GAPDH 
                 Glyceraldehyde-3- 
                 IPI:IPI00219018.7 
                 GALQNIIPASTGAAK 
                 2.28 
                 1.61 
                 1.42 
               
               
                   
                 phosphate dehydrogenase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GAPDH 
                 Glyceraldehyde-3- 
                 IPI:IPI00219018.7 
                 VDIVAINDPFIDLNYMVYMF 
                 0.81 
                 1.39 
                 0.58 
               
               
                   
                 phosphate dehydrogenase 
                   
                 QYDSTHGK 
                   
                   
                   
               
               
                   
               
               
                 GAPDH 
                 Glyceraldehyde-3- 
                 IPI:IPI00219018.7 
                 VVDLMAHMASKE 
                 1.18 
                 0.57 
                 2.08 
               
               
                   
                 phosphate dehydrogenase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GC 
                 Vitamin D-binding  
                 IPI:IPI00555812.4 
                 DKYTFELSR 
                 0.63 
                 0.17 
                 3.70 
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GC 
                 Vitamin D-binding  
                 IPI:IPI00555812.4 
                 ELSSFIDK 
                 15.57 
                 10.11 
                 1.54 
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GC 
                 Vitamin D-binding  
                 IPI:IPI00555812.4 
                 SINSPPLYCDSEIDAELKNIL 
                   
                 0.13 
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GGH 
                 Gamma-glutamyl 
                 IPI:IPI00023728.1 
                 MFQNFPTELLLSLAVEPLTA 
                 0.18 
                   
                   
               
               
                   
                 hydrolase 
                   
                 NFHK 
                   
                   
                   
               
               
                   
               
               
                 GGH 
                 Gamma-glutamyl 
                 IPI:IPI00023728.1 
                 TAFYLAEFFVNEAR 
                 0.20 
                   
                   
               
               
                   
                 hydrolase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GLRX 
                 Glutaredoxin-1 
                 IPI:IPI00219025.3 
                 LKQIGALQ 
                 85.27 
                 121.89 
                 0.70 
               
               
                   
               
               
                 GOLGA4 
                 Isoform 1 of Golgin 
                 IPI:IPI00013272.1 
                 EFNTQLAQKE 
                 0.20 
                   
                   
               
               
                   
                 subfamily A member 4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GP1BA 
                 platelet glycoprotein  
                 IPI:IPI00748955.2 
                 LTSLPLGALR 
                 0.87 
                 0.91 
                 0.95 
               
               
                   
                 Ib alpha polypeptide 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GP1BA 
                 platelet glycoprotein  
                 IPI:IPI00748955.2 
                 TLPPGLLTPTPK 
                 0.46 
                 0.30 
                 1.56 
               
               
                   
                 Ib alpha polypeptide 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GPLD1 
                 Isoform 1 of 
                 IPI:IPI00299503.2 
                 FGGVLHLSDLDDDGLDEIIM 
                 0.22 
                 0.56 
                 0.40 
               
               
                   
                 Phosphatidylinositol- 
                   
                 AAPLR 
                   
                   
                   
               
               
                   
                 glycan-specific 
                   
                   
                   
                   
                   
               
               
                   
                 phospholipase D 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GPLD1 
                 Isoform 1 of 
                 IPI:IPI00299503.2 
                 ILEGFQPSGR 
                 0.32 
                 0.57 
                 0.56 
               
               
                   
                 Phosphatidylinositol- 
                   
                   
                   
                   
                   
               
               
                   
                 glycan-specific 
                   
                   
                   
                   
                   
               
               
                   
                 phospholipase D 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GPT 
                 Alanine amino- 
                 IPI:IPI00217458.3 
                 LLVAGEGHTR 
                 0.11 
                   
                   
               
               
                   
                 transferase 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GRM5 
                 glutamate receptor, 
                 IPI:IPI00789949.1 
                 KRDQTLMLSFMR 
                 0.96 
                 1.62 
                 0.59 
               
               
                   
                 metabotropic 5 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 GSG1L 
                 GSG1-like isoform 1 
                 IPI:IPI00152159.3 
                 SFIDLAPASEK 
                 0.73 
                 0.58 
                 1.26 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 AGALNSNDAFVLK 
                 12.54 
                 24.33 
                 0.52 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 AGKEPGLQIWR 
                 5.68 
                 12.22 
                 0.47 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 AQPVQVAEGSEPDGFWEAL 
                 2.43 
                 5.88 
                 0.41 
               
               
                   
                   
                   
                 GGK 
                   
                   
                   
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 AVEVLPK 
                 1.49 
                 2.94 
                 0.51 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 DSQEEEKTEALTSAK 
                 0.76 
                 1.43 
                 0.54 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 EGGQTAPASTR 
                 0.23 
                 0.36 
                 0.64 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 EVQGFESATFLGYFK 
                 5.76 
                 11.95 
                 0.48 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 GASQAGAPQGR 
                 1.32 
                 2.71 
                 0.49 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 GGVASGFK 
                 0.31 
                 0.61 
                 0.51 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 HVVPNEVVVQR 
                 9.30 
                 19.43 
                 0.48 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 IEGSNKVPVDPATYGQFYG 
                 2.55 
                 4.09 
                 0.63 
               
               
                   
                   
                   
                 GDSYIILYNYR 
                   
                   
                   
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 MDAHPPR 
                 1.71 
                 3.33 
                 0.51 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 PALPAGTEDTAKEDAANR 
                 0.16 
                 0.28 
                 0.57 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 QTQVSVLPEGGETPLFK 
                 9.00 
                 19.74 
                 0.46 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 RYIETDPANR 
                 0.21 
                 0.37 
                 0.56 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 TASDFITK 
                 6.07 
                 12.18 
                 0.50 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 TGAQELLR 
                 8.51 
                 17.56 
                 0.48 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 TPITVVK 
                 0.66 
                 1.32 
                 0.50 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 TPSAAYLWVGTGASEAEK 
                 2.75 
                 5.59 
                 0.49 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 TPSAAYLWVGTGASEAEKT 
                 1.04 
                 3.40 
                 0.31 
               
               
                   
                   
                   
                 GAQELLR 
                   
                   
                   
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 VPEARPNSMVVEHPEFLK 
                 5.34 
                 12.46 
                 0.43 
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 VPFDAATLHTSTAMAAQHG 
                 7.35 
                 15.87 
                 0.46 
               
               
                   
                   
                   
                 MDDDGTGQK 
                   
                   
                   
               
               
                   
               
               
                 GSN 
                 Gelsolin 
                 IPI:IPI00026314.1 
                 YIETDPANR 
                 1.99 
                 4.32 
                 0.46 
               
               
                   
               
               
                 GULP1 
                 Isoform 1 of PTB  
                 IPI:IPI00790010.1 
                 IQDLETENMELK 
                 1.14 
                   
                   
               
               
                   
                 domain-containing 
                   
                   
                   
                   
                   
               
               
                   
                 engulfment 
                   
                   
                   
                   
                   
               
               
                   
                 adapter protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HBA2;  
                 Hemoglobin subunit  
                 IPI:IPI00410714.5 
                 MFLSFPTTK 
                 10.38 
                 26.76 
                 0.39 
               
               
                   
               
               
                 HBA1 
                 alpha 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HELLS 
                 Isoform 1 of Lymphoid- 
                 IPI:IPI00010590.2 
                 NKDSNSIIK 
                 0.17 
                   
                   
               
               
                   
                 specific helicase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HGFAC 
                 Hepatocyte growth  
                 IPI:IPI00029193.1 
                 EALVPLVADHK 
                 0.41 
                 0.52 
                 0.77 
               
               
                   
                 factor activator 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HOM-TES-1 
                 hypothetical protein 
                 IPI:IPI00022868.3 
                 MKVDMDICR 
                 0.44 
                 0.43 
                 1.04 
               
               
                   
                 LOC25900 isoform 4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HP 
                 Haptoglobin 
                 IPI:IPI00641737.1 
                 HYEGSTVPEK 
                 3.73 
                 1.42 
                 2.62 
               
               
                   
               
               
                 HP 
                 Haptoglobin 
                 IPI:IPI00641737.1 
                 LRTEGDGVYTLNDK 
                 10.04 
                 0.37 
                 27.05 
               
               
                   
               
               
                 HP 
                 Haptoglobin 
                 IPI:IPI00641737.1 
                 PECEAVCGKPK 
                   
                 0.09 
                   
               
               
                   
               
               
                 HPR 
                 Isoform 1 of  
                 IPI:IPI00477597.1 
                 LRTEGDGVYTLNDK 
                 10.04 
                 0.37 
                 27.05 
               
               
                   
                 Haptoglobin- 
                   
                   
                   
                   
                   
               
               
                   
                 related protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HPR 
                 Isoform 1 of  
                 IPI:IPI00477597.1 
                 PECEAVCGKPK 
                   
                 0.09 
                   
               
               
                   
                 Haptoglobin- 
                   
                   
                   
                   
                   
               
               
                   
                 related protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HPX 
                 Hemopexin 
                 IPI:IPI00022488.1 
                 EVGTPHGIILDSVDAAFICPG 
                 0.90 
                 1.92 
                 0.47 
               
               
                   
                   
                   
                 SSR 
                   
                   
                   
               
               
                   
               
               
                 HPX 
                 Hemopexin 
                 IPI:IPI00022488.1 
                 VDGALCMEK 
                 3.41 
                 3.81 
                 0.90 
               
               
                   
               
               
                 HPX 
                 Hemopexin 
                 IPI:IPI00022488.1 
                 YYCFQGNQFLR 
                 3.47 
                 5.76 
                 0.60 
               
               
                   
               
               
                 HRG 
                 Histidine-rich  
                 IPI:IPI00022371.1 
                 DVEALDLESPK 
                   
                 0.24 
                   
               
               
                   
                 glycoprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HSPA8 
                 Heat shock 70 kDa 
                 IPI:IPI00795040.1 
                 DAGTIAGLNVLR 
                 0.33 
                   
                   
               
               
                   
                 protein 8 isoform  
                   
                   
                   
                   
                   
               
               
                   
                 2 variant (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 HSPA8 
                 Heat shock 70 kDa  
                 IPI:IPI00795040.1 
                 NQVAMNPTNTVFDAKR 
                 0.30 
                   
                   
               
               
                   
                 protein 8 isoform  
                   
                   
                   
                   
                   
               
               
                   
                 2 variant (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ICAM1 
                 Intercellular adhesion 
                 IPI:IPI00008494.4 
                 LLGIETPLPK 
                 0.80 
                   
                   
               
               
                   
                 molecule 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ICAM1 
                 Intercellular adhesion 
                 IPI:IPI00008494.4 
                 VELAPLPSWQPVGK 
                 0.57 
                   
                   
               
               
                   
                 molecule 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGF1 
                 Insulin-like growth  
                 IPI:IPI00001610.1 
                 RLEMYCAPLKPAK 
                   
                 0.37 
                   
               
               
                   
                 factor IA 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGFALS 
                 Insulin-like growth  
                 IPI:IPI00020996.3 
                 LAYLQPALFSGLAELR 
                 3.49 
                 3.14 
                 1.11 
               
               
                   
                 factor-binding  
                   
                   
                   
                   
                   
               
               
                   
                 protein complex 
                   
                   
                   
                   
                   
               
               
                   
                 acid labile chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGFALS 
                 Insulin-like growth  
                 IPI:IPI00020996.3 
                 NLIAAVAPGAFLGLK 
                 2.08 
                 2.02 
                 1.03 
               
               
                   
                 factor-binding  
                   
                   
                   
                   
                   
               
               
                   
                 protein complex 
                   
                   
                   
                   
                   
               
               
                   
                 acid labile chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGFBP2 
                 Insulin-like growth  
                 IPI:IPI00297284.1 
                 GGKHHLGLEEPK 
                   
                 0.17 
                   
               
               
                   
                 factor-binding  
                   
                   
                   
                   
                   
               
               
                   
                 protein 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGFBP6 
                 Insulin-like growth  
                 IPI:IPI00029235.1 
                 HLDSVLQQLQTEVYR 
                   
                 0.28 
                   
               
               
                   
                 factor-binding  
                   
                   
                   
                   
                   
               
               
                   
                 protein 6 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 IGHM 
                 IGHM protein 
                 IPI:IPI00477090.6 
                 LICQATGFSPR 
                   
                 0.25 
                   
               
               
                   
               
               
                 IGL@ 
                 IGL@ protein 
                 IPI:IPI00154742.6 
                 ATLVCLISDFYPGAVTVAW 
                 1.60 
                 0.45 
                 3.58 
               
               
                   
                   
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 IGLV7-43 
                 Ig lambda chain V  
                 IPI:IPI00022890.1 
                 FSGSLLGGK 
                 0.38 
                   
                   
               
               
                   
                 region 4A 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITGA2B 
                 integrin alpha 2b 
                 IPI:IPI00218629.2 
                 NVGSQTLQTFK 
                   
                 0.25 
                   
               
               
                   
                 preproprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 DTAVDGVFIR 
                   
                 0.13 
                   
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 ELAAQTIKK 
                 8.21 
                 14.31 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 EVAFDLEIPK 
                 28.72 
                 46.70 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 FAHYVVTSQVVNTANEAR 
                 10.92 
                 17.76 
                 0.61 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 GHMLENHVER 
                 6.40 
                 11.30 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 GIEILNQVQESLPELSNHASI 
                 3.42 
                 4.93 
                 0.69 
               
               
                   
                 inhibitor heavy  
                   
                 LIMLTDGDPTEGVTDR 
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 GMADQDGLKPTIDKPSEDSP 
                 27.16 
                 43.87 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                 PLEMLGPR 
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 GSLVQASEANLQAAQDFVR 
                 15.68 
                 24.71 
                 0.63 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 IADNKQSSFK 
                 0.86 
                 1.16 
                 0.74 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 ILGDMQPGDYFDLVLFGTR 
                 22.32 
                 47.17 
                 0.47 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 KAAISGENAGLVR 
                 7.53 
                 12.44 
                 0.61 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 MSLDYGFVTPLTSMSIR 
                 10.01 
                 17.68 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 MSLDYGFVTPLTSMSIR 
                   
                 0.28 
                   
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 NHMQYEIVIK 
                 11.50 
                 17.77 
                 0.65 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 QAVDTAVDGVFIR 
                 10.25 
                 16.99 
                 0.60 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 QYYEGSEIVVAGR 
                 2.23 
                 1.21 
                 1.84 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 RQAVDTAVDGVFIR 
                 0.50 
                 0.58 
                 0.86 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 VTFQLTYEEVLKR 
                 5.67 
                 7.77 
                 0.73 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH1 
                 Inter-alpha-trypsin 
                 IPI:IPI00292530.1 
                 VTYDVSR 
                 6.57 
                 10.00 
                 0.66 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 AIFILNEANNLGLLDPNSVSL 
                 4.89 
                 8.31 
                 0.59 
               
               
                   
                 inhibitor heavy  
                   
                 IILVSDGDPTVGELK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 DKHADPDFTR 
                 3.35 
                 5.99 
                 0.56 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 ENIQDNISLFSLGMGFDVDY 
                 2.43 
                 4.88 
                 0.50 
               
               
                   
                 inhibitor heavy  
                   
                 DFLKR 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 FDPAKLDQIESVITATSANT 
                 6.94 
                 12.15 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                 QLVLETLAQMDDLQDFLSK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 FDPAKLDQIESVITATSANT 
                 6.94 
                 12.15 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                 QLVLETLAQMDDLQDFLSK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 FDPAKLDQIESVITATSANT 
                   
                 0.09 
                   
               
               
                   
                 inhibitor heavy  
                   
                 QLVLETLAQMDDLQDFLSK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 FLHVPDTFEGHFDGVPVISK 
                 42.05 
                 67.72 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 FYNQVSTPLLR 
                 31.04 
                 54.21 
                 0.57 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 HADPDFTR 
                 8.05 
                 12.82 
                 0.63 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 IQPSGGTNINEALLR 
                 45.53 
                 79.08 
                 0.58 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 IYGNQDTSSQLK 
                 3.74 
                 4.70 
                 0.80 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 IYGNQDTSSQLKK 
                 8.17 
                 13.87 
                 0.59 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 IYLQPGR 
                 17.11 
                 30.41 
                 0.56 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 KLGSYEHR 
                 3.86 
                 7.12 
                 0.54 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 LDQIESVITATSANTQLVLET 
                 4.61 
                 4.60 
                 1.00 
               
               
                   
                 inhibitor heavy  
                   
                 LAQMDDLQDFLSK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 LGSYEHR 
                 3.06 
                 4.94 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 LSNENHGIAQR 
                 10.44 
                 16.74 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 MATTMIQSK 
                 20.18 
                 33.27 
                 0.61 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 MKQTVEAMK 
                 4.20 
                 7.89 
                 0.53 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 NDLISATK 
                 11.30 
                 17.66 
                 0.64 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 NVKENIQDNISLFSLGMGFD 
                   
                 0.18 
                   
               
               
                   
                 inhibitor heavy  
                   
                 VDYDFLKR 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 NVQFNYPHTSVTDVTQNNF 
                 6.10 
                 9.78 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                 HNYFGGSEIVVAGK 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 PSGGTNINEALLR 
                 1.96 
                 4.07 
                 0.48 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 SSALDMENFR 
                 29.97 
                 50.84 
                 0.59 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 SSALDMENFR 
                 0.20 
                 0.32 
                 0.62 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 TAGLVR 
                 5.34 
                 9.84 
                 0.54 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 TEVNVLPGAK 
                 29.65 
                 49.53 
                 0.60 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 TILDDLRAEDHFSVIDFNQNI 
                 29.54 
                 49.72 
                 0.59 
               
               
                   
                 inhibitor heavy  
                   
                 R 
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 TWRNDLISATK 
                 2.54 
                 4.23 
                 0.60 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 VQFELHYQEVK 
                 10.70 
                 23.59 
                 0.45 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 VQSTITSR 
                 15.02 
                 25.32 
                 0.59 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH2 
                 Inter-alpha-trypsin 
                 IPI:IPI00305461.2 
                 VVNNSPQPQNVVFDVQIPK 
                 17.70 
                 31.88 
                 0.56 
               
               
                   
                 inhibitor heavy  
                   
                   
                   
                   
                   
               
               
                   
                 chain H2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 AREEHRIPER 
                 0.21 
                 0.57 
                 0.36 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 ESPGNVQIVNGYFVHFFAPQ 
                 0.48 
                 0.56 
                 0.86 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                 GLPVVPK 
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 MSAQTHGLLGQFFQPFDFK 
                 0.35 
                   
                   
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 SMEDKGMTNINDGLLR 
                 0.15 
                 0.78 
                 0.19 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 TAGLVK 
                 4.87 
                 7.26 
                 0.67 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH3 
                 Isoform 1 of Inter- 
                 IPI:IPI00028413.8 
                 VSDIRPGSDPTKPDATLVVK 
                 0.66 
                   
                   
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH4 
                 Isoform 1 of Inter- 
                 IPI:IPI00294193.4 
                 FAHTVVTSR 
                 35.36 
                 43.76 
                 0.81 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH4 
                 Isoform 1 of Inter- 
                 IPI:IPI00294193.4 
                 ILDDLSPR 
                 41.07 
                 49.94 
                 0.82 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH4 
                 Isoform 1 of Inter- 
                 IPI:IPI00294193.4 
                 NVVFVIDK 
                 27.71 
                 34.54 
                 0.80 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 ITIH4 
                 Isoform 1 of Inter- 
                 IPI:IPI00294193.4 
                 SAGLVK 
                 5.38 
                 6.71 
                 0.80 
               
               
                   
                 alpha-trypsin inhibitor  
                   
                   
                   
                   
                   
               
               
                   
                 heavy chain H4 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KIAA0423 
                 Isoform 1 of 
                 IPI:IPI00744872.2 
                 LHDSNSK 
                   
                 0.23 
                   
               
               
                   
                 Uncharacterized protein 
                   
                   
                   
                   
                   
               
               
                   
                 KIAA0423 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KLKB1 
                 Plasma kallikrein 
                 IPI:IPI00654888.4 
                 YSPGGTPTAIK 
                 2.25 
                 3.35 
                 0.67 
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 AATGECTATVGKR 
                 0.38 
                 0.72 
                 0.53 
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 AVDAALKK 
                 18.44 
                 29.10 
                 0.63 
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 DIPTNSPELEETLTHTITK 
                 47.87 
                 61.90 
                 0.77 
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 KYFIDFVAR 
                 18.42 
                 24.78 
                 0.74 
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 QVVAGLNFR 
                 23.86 
                 34.40 
                 0.69 
               
               
                   
               
               
                 KNG1 
                 Isoform HMW of 
                 IPI:IPI00032328.2 
                 SVSEINPTTQMK 
                 0.20 
                 0.42 
                 0.49 
               
               
                   
                 Kininogen-1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KNG1 
                 Kininogen-1 
                 IPI:IPI00032328.2 
                 YFIDFVAR 
                 28.85 
                 40.11 
                 0.72 
               
               
                   
               
               
                 KRT10 
                 Keratin, type I  
                 IPI:IPI00009865.2 
                 GSLGGGFSSGGFSGGSFSR 
                 2.13 
                   
                   
               
               
                   
                 cytoskeletal 10 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KRT10 
                 Keratin, type I  
                 IPI:IPI00009865.2 
                 SKELTTEIDNNIEQISSYK 
                 3.04 
                 3.69 
                 0.83 
               
               
                   
                 cytoskeletal 10 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KRT10 
                 Keratin, type I  
                 IPI:IPI00009865.2 
                 VTMQNLNDR 
                 1.07 
                 0.19 
                 5.65 
               
               
                   
                 cytoskeletal 10 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KRT2 
                 Keratin, type II  
                 IPI:IPI00021304.1 
                 NLDLDSIIAEVKAQYEEIAQ 
                 3.75 
                   
                   
               
               
                   
                 cytoskeletal 
                   
                 R 
                   
                   
                   
               
               
                   
                 2 epidermal 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 KRT2 
                 Keratin, type II  
                 IPI:IPI00021304.1 
                 VDLLNQEIEFLK 
                 1.00 
                   
                   
               
               
                   
                 cytoskeletal 
                   
                   
                   
                   
                   
               
               
                   
                 2 epidermal 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 ATAQMLEVMFK 
                 0.88 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 GLQYAAQEGLLALQSELLR 
                 0.36 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 ITGFLKPGK 
                 0.61 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 ITLPDFTGDLR 
                 1.32 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 SFRPFVPR 
                 0.59 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LBP 
                 Lipopolysaccharide- 
                 IPI:IPI00032311.4 
                 SPVTLLAAVMSLPEEHNK 
                 0.70 
                   
                   
               
               
                   
                 binding protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LCP1 
                 Plastin-2 
                 IPI:IPI00010471.5 
                 FSLVGIGGQDLNEGNR 
                 0.43 
                   
                   
               
               
                   
               
               
                 LCP1 
                 Plastin-2 
                 IPI:IPI00010471.5 
                 IKVPVDWNR 
                 0.27 
                   
                   
               
               
                   
               
               
                 LCP1 
                 Plastin-2 
                 IPI:IPI00010471.5 
                 QFVTATDVVR 
                 0.49 
                   
                   
               
               
                   
               
               
                 LDHB 
                 L-lactate   
                 IPI:IPI00219217.3 
                 GLTSVINQK 
                 0.47 
                 0.29 
                 1.64 
               
               
                   
                 dehydrogenase 
                   
                   
                   
                   
                   
               
               
                   
                 B chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LDHB 
                 L-lactate   
                 IPI:IPI00219217.3 
                 IVADKDYSVTANSK 
                 0.16 
                 0.06 
                 2.44 
               
               
                   
                 dehydrogenase 
                   
                   
                   
                   
                   
               
               
                   
                 B chain 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LIFR 
                 Leukemia inhibitory  
                 IPI:IPI00444272.2 
                 QFLIPPK 
                 409.27 
                 695.10 
                 0.59 
               
               
                   
                 factor receptor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LPA 
                 Apolipoprotein 
                 IPI:IPI00029168.1 
                 GTLSTTITGR 
                 0.37 
                 0.36 
                 1.01 
               
               
                   
               
               
                 LPA 
                 Apolipoprotein 
                 IPI:IPI00029168.1 
                 GTYSTTVTGR 
                 1.57 
                 5.41 
                 0.29 
               
               
                   
               
               
                 LRG1 
                 Leucine-rich alpha-2- 
                 IPI:IPI00022417.4 
                 LGHLDLSGNR 
                 0.25 
                 0.22 
                 1.13 
               
               
                   
                 glycoprotein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 FNALQYLR 
                 2.01 
                 4.54 
                 0.44 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 LKEDAVSAAFK 
                 6.20 
                 12.80 
                 0.48 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 LPSGLPVSLLTLYLDNNK 
                 1.43 
                 3.74 
                 0.38 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 NIPTVNENLENYYLEVNQLE 
                 0.94 
                 2.93 
                 0.32 
               
               
                   
                   
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 NNQIDHIDEK 
                 0.22 
                 0.61 
                 0.37 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 SLEDLQLTHNK 
                 6.71 
                 13.68 
                 0.49 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 SLEYLDLSFNQIAR 
                 2.86 
                 6.69 
                 0.43 
               
               
                   
               
               
                 LUM 
                 Lumican 
                 IPI:IPI00020986.2 
                 SVPMVPPGIK 
                 2.29 
                 4.55 
                 0.50 
               
               
                   
               
               
                 MASP1 
                 mannan-binding lectin 
                 IPI:IPI00290283.6 
                 TLSDVLQYVK 
                 0.18 
                 0.29 
                 0.64 
               
               
                   
                 serine protease 1  
                   
                   
                   
                   
                   
               
               
                   
                 isoform 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MBL2 
                 Mannose-binding  
                 IPI:IPI00004373.1 
                 FQASVATPR 
                 4.84 
                 2.46 
                 1.97 
               
               
                   
                 protein C 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MCAM 
                 Isoform 1 of Cell  
                 IPI:IPI00016334.2 
                 IFLCQGK 
                 2.53 
                 1.50 
                 1.68 
               
               
                   
                 surface 
                   
                   
                   
                   
                   
               
               
                   
                 glycoprotein MUC18 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MED12L 
                 Isoform 4 of Mediator  
                 IPI:IPI00044353.6 
                 LDPAGSFVPTNTK 
                   
                 0.41 
                   
               
               
                   
                 of RNA polymerase II 
                   
                   
                   
                   
                   
               
               
                   
                 transcription subunit  
                   
                   
                   
                   
                   
               
               
                   
                 12-like protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MEGF8 
                 Isoform 1 of Multiple 
                 IPI:IPI00027310.4 
                 SFHAAAYVPAGR 
                 5.16 
                 8.22 
                 0.63 
               
               
                   
                 epidermal growth  
                   
                   
                   
                   
                   
               
               
                   
                 factor-like  
                   
                   
                   
                   
                   
               
               
                   
                 domains 8 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MMP8 
                 Neutrophil collagenase 
                 IPI:IPI00027846.1 
                 YYAFDLIAQR 
                   
                 0.45 
                   
               
               
                   
               
               
                 MSN 
                 Moesin 
                 IPI:IPI00219365.3 
                 IGFPWSEIR 
                 0.27 
                   
                   
               
               
                   
               
               
                 MTMR15 
                 Isoform 1 of  
                 IPI:IPI00007317.4 
                 RLEPTIK 
                 27.01 
                 34.25 
                 0.79 
               
               
                   
                 Coiled-coil 
                   
                   
                   
                   
                   
               
               
                   
                 domain-containing 
                   
                   
                   
                   
                   
               
               
                   
                 protein MTMR15 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 MYCBP2 
                 Putative uncharacterized 
                 IPI:IPI00383833.1 
                 KECEKENK 
                   
                 1.11 
                   
               
               
                   
                 protein DKFZp586G0322 
                   
                   
                   
                   
                   
               
               
                   
                 (Fragment) 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 NRCAM 
                 Isoform 1 of Neuronal  
                 IPI:IPI00333776.5 
                 DSTGTYTCVAR 
                 0.16 
                   
                   
               
               
                   
                 cell adhesion molecule 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 NRP1 
                 Neuropilin 1 
                 IPI:IPI00398715.5 
                 IKPATWETGISMR 
                 0.33 
                   
                   
               
               
                   
               
               
                 OLFM1 
                 Isoform 1 of Noelin 
                 IPI:IPI00017841.2 
                 VSNLEER 
                 1.10 
                 1.90 
                 0.58 
               
               
                   
               
               
                 ORM1 
                 Alpha-l-acid  
                 IPI:IPI00022429.3 
                 YVGGQEHFAHLLILR 
                 2.42 
                 3.78 
                 0.64 
               
               
                   
                 glycoprotein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PCSK9 
                 Isoform 1 of Proprotein 
                 IPI:IPI00387168.1 
                 VMVTDFENVPEEDGTR 
                 0.67 
                 0.33 
                 2.00 
               
               
                   
                 convertase subtilisin/ 
                   
                   
                   
                   
                   
               
               
                   
                 kexin type 9 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PCYOX1 
                 Prenylcysteine  
                 IPI:IPI00384280.5 
                 LFLSYDYAVK 
                   
                 0.11 
                   
               
               
                   
                 oxidase 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PDIA3 
                 Protein disulfide- 
                 IPI:IPI00025252.1 
                 ELSDFISYLQR 
                 0.23 
                   
                   
               
               
                   
                 isomerase A3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PDIA3 
                 Protein disulfide- 
                 IPI:IPI00025252.1 
                 TFSHELSDFGLESTAGEIPVV 
                 0.23 
                   
                   
               
               
                   
                 isomerase A3 
                   
                 AIR 
                   
                   
                   
               
               
                   
               
               
                 PDIA3 
                 Protein disulfide- 
                 IPI:IPI00025252.1 
                 YGVSGYPTLK 
                 0.33 
                 0.45 
                 0.72 
               
               
                   
                 isomerase A3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PEBP4 
                 PEBP family protein 
                 IPI:IPI00163563.3 
                 HWLVTDIK 
                   
                 0.37 
                   
               
               
                   
               
               
                 PFN1 
                 Profilin-1 
                 IPI:IPI00216691.5 
                 DSLLQDGEFSMDLR 
                 1.52 
                 1.28 
                 1.19 
               
               
                   
               
               
                 PGLYRP2 
                 N-acetylmuramoyl-L- 
                 IPI:IPI00163207.1 
                 AGLLRPDYALLGHR 
                 2.21 
                 3.02 
                 0.73 
               
               
                   
                 alanine amidase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PGLYRP2 
                 Isoform 1 of N- 
                 IPI:IPI00163207.1 
                 EGKEYGVVLAPDGSTVAVE 
                 1.60 
                 3.38 
                 0.47 
               
               
                   
                 acetylmuramoyl-L-alanine 
                   
                 PLLAGLEAGLQGR 
                   
                   
                   
               
               
                   
                 amidase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PGLYRP2 
                 Isoform 1 of N- 
                 IPI:IPI00163207.1 
                 RVINLPLDSMAAPWETGDT 
                 0.81 
                 0.86 
                 0.94 
               
               
                   
                 acetylmuramoyl-L-alanine 
                   
                 FPDVVAIAPDVR 
                   
                   
                   
               
               
                   
                 amidase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PGLYRP2 
                 Isoform 1 of N- 
                 IPI:IPI00163207.1 
                 TFTLLDPK 
                 3.40 
                 6.16 
                 0.55 
               
               
                   
                 acetylmuramoyl-L-alanine 
                   
                   
                   
                   
                   
               
               
                   
                 amidase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PGLYRP2 
                 Isoform 1 of N- 
                 IPI:IPI00163207.1 
                 WGAAPYR 
                 0.73 
                 0.57 
                 1.27 
               
               
                   
                 acetylmuramoyl-L-alanine 
                   
                   
                   
                   
                   
               
               
                   
                 amidase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PI16 
                 Isoform 1 of Peptidase 
                 IPI:IPI00301143.5 
                 AQVSPTASDMLHMR 
                   
                 0.37 
                   
               
               
                   
                 inhibitor 16 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PI16 
                 Isoform 1 of Peptidase 
                 IPI:IPI00301143.5 
                 LMVELHNLYR 
                 0.19 
                 0.68 
                 0.27 
               
               
                   
                 inhibitor 16 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PLEK 
                 Pleckstrin 
                 IPI:IPI00306311.8 
                 NRQEGLMIASSLLNEGYLQP 
                 0.32 
                 0.53 
                 0.60 
               
               
                   
                   
                   
                 AGDMSK 
                   
                   
                   
               
               
                   
               
               
                 PNP 
                 Purine nucleoside 
                 IPI:IPI00871140.1 
                 VIMDYESLEK 
                 0.16 
                   
                   
               
               
                   
                 phosphorylase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PODXL 
                 Podocalyxin-like  
                 IPI:IPI00299116.1 
                 EITIHTK 
                 0.47 
                 0.82 
                 0.57 
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 POLR2A 
                 DNA-directed RNA 
                 IPI:IPI00031627.3 
                 MDDDVFLRCIESNMLTDMT 
                 0.27 
                   
                   
               
               
                   
                 polymerase II subunit 
                   
                 LQGI 
                   
                   
                   
               
               
                   
                 RPB1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 POSTN 
                 Isoform 1 of Periostin 
                 IPI:IPI00007960.4 
                 DGHFTLFAPTNEAFEK 
                 3.19 
                 5.78 
                 0.55 
               
               
                   
               
               
                 PPAN 
                 Protein 
                 IPI:IPI00853545.1 
                 RRWSTR 
                 0.17 
                 0.36 
                 0.46 
               
               
                   
               
               
                 PPBP 
                 Platelet basic protein 
                 IPI:IPI00022445.1 
                 DSDLYAELR 
                 0.42 
                 0.19 
                 2.17 
               
               
                   
               
               
                 PRDX2 
                 Peroxiredoxin-2 
                 IPI:IPI00027350.3 
                 IGKPAPDFK 
                 0.64 
                   
                   
               
               
                   
               
               
                 PRDX2 
                 Peroxiredoxin-2 
                 IPI:IPI00027350.3 
                 QITVNDLPVGR 
                 0.47 
                   
                   
               
               
                   
               
               
                 PROZ 
                 Isoform 1 of Vitamin  
                 IPI:IPI00027843.1 
                 RAPDLQDLPWQVK 
                 0.21 
                 0.33 
                 0.63 
               
               
                   
                 K-dependent protein Z 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PSAT1 
                 Isoform 1 of  
                 IPI:IPI00001734.2 
                 FGTINIVHPK 
                   
                 0.30 
                   
               
               
                   
                 Phosphoserine 
                   
                   
                   
                   
                   
               
               
                   
                 aminotransferase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PSMB2 
                 Proteasome subunit beta 
                 IPI:IPI00028006.1 
                 NGYELSPTAAANFTR 
                   
                 0.15 
                   
               
               
                   
                 type-2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PTCHD2 
                 Isoform 2 of Patched 
                 IPI:IPI00002283.8 
                 ETPPLEDLAANQSEDPRNQR 
                   
                 0.14 
                   
               
               
                   
                 domain-containing  
                   
                 LSK 
                   
                   
                   
               
               
                   
                 protein 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PTGDS 
                 Prostaglandin-H2 D- 
                 IPI:IPI00013179.1 
                 APEAQVSVQPNFQQDK 
                   
                 5.15 
                   
               
               
                   
                 isomerase 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PVR 
                 Isoform Beta of  
                 IPI:IPI00219425.3 
                 VLAKPQNTAEVQK 
                 0.09 
                   
                   
               
               
                   
                 Poliovirus receptor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 PZP 
                 Pregnancy zone protein 
                 IPI:IPI00025426.2 
                 AFQPFFVELTMPYSVIR 
                 7.72 
                 0.32 
                 24.32 
               
               
                   
               
               
                 PZP 
                 Pregnancy zone protein 
                 IPI:IPI00025426.2 
                 ATVLNYLPK 
                 7.93 
                 0.43 
                 18.58 
               
               
                   
               
               
                 PZP 
                 Pregnancy zone protein 
                 IPI:IPI00025426.2 
                 QGIPFFAQVLLVDGK 
                   
                 0.12 
                   
               
               
                   
               
               
                 PZP 
                 Pregnancy zone protein 
                 IPI:IPI00025426.2 
                 VVVQTESGGR 
                   
                 0.08 
                   
               
               
                   
               
               
                 QSOX1 
                 Isoform 1 of Sulfhydryl 
                 IPI:IPI00003590.2 
                 VLNTEANVVR 
                   
                 0.07 
                   
               
               
                   
                 oxidase 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 RBP4 
                 Plasma retinol-binding 
                 IPI:IPI00022420.3 
                 FSGTWYAMAK 
                   
                 0.59 
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 RBP4 
                 Plasma retinol-binding 
                 IPI:IPI00022420.3 
                 LIVHNGYCDGR 
                   
                 0.29 
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 RBP4 
                 Plasma retinol-binding 
                 IPI:IPI00022420.3 
                 MKYWGVASFLQK 
                   
                 2.10 
                   
               
               
                   
                 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 RELN 
                 reelin isoform a 
                 IPI:IPI00241562.4 
                 TSGITCIKPR 
                   
                 0.67 
                   
               
               
                   
               
               
                 RERE 
                 Isoform 1 of Arginine- 
                 IPI:IPI00185027.4 
                 KVKEEASSPLK 
                   
                 0.12 
                   
               
               
                   
                 glutamic acid dipeptide 
                   
                   
                   
                   
                   
               
               
                   
                 repeats protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SAA1; SAA2 
                 serum amyloid A2 
                 IPI:IPI00006146.4 
                 EANYIGSDK 
                 1.45 
                 0.77 
                 1.89 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 EANYIGSDK 
                 1.45 
                 0.77 
                 1.89 
               
               
                   
               
               
                 SAA1; SAA2 
                 serum amyloid A2 
                 IPI:IPI00006146.4 
                 EANYIGSDKYFHAR 
                 2.19 
                 1.22 
                 1.80 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 EANYIGSDKYFHAR 
                 2.19 
                 1.22 
                 1.80 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 FFGHGAEDSLADQAANEW 
                 4.65 
                 1.07 
                 4.34 
               
               
                   
                   
                   
                 GR 
                   
                   
                   
               
               
                   
               
               
                 SAA1; SAA2 
                 serum amyloid A2 
                 IPI:IPI00006146.4 
                 FFSFLGEAFDGAR 
                 2.62 
                   
                   
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 FFSFLGEAFDGAR 
                 2.62 
                   
                   
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 RGPGGVWAAEAISDAR 
                 4.82 
                 4.49 
                 1.07 
               
               
                   
               
               
                 SAA1; SAA2 
                 serum amyloid A2 
                 IPI:IPI00006146.4 
                 RSFFSFLGEAFDGAR 
                 3.01 
                 2.41 
                 1.25 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 RSFFSFLGEAFDGAR 
                 3.01 
                 2.41 
                 1.25 
               
               
                   
               
               
                 SAA1; SAA2 
                 serum amyloid A2 
                 IPI:IPI00006146.4 
                 SFFSFLGEAFDGAR 
                 8.44 
                 6.76 
                 1.25 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 SFFSFLGEAFDGAR 
                 8.44 
                 6.76 
                 1.25 
               
               
                   
               
               
                 SAA1; SAA2 
                 Serum amyloid A protein 
                 IPI:IPI00552578.2 
                 SGKDPNHFRPAGLPEKY 
                 5.36 
                   
                   
               
               
                   
               
               
                 SAA4 
                 Serum amyloid  
                 IPI:IPI00019399.1 
                 EALQGVGDMGR 
                 11.54 
                 7.35 
                 1.57 
               
               
                   
                 A-4 protein 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SAA4 
                 Serum amyloid  
                 IPI:IPI00019399.1 
                 VYLQGLIDYYLFGNSSTVLE 
                 0.56 
                 0.19 
                 2.92 
               
               
                   
                 A-4 protein 
                   
                 DSK 
                   
                   
                   
               
               
                   
               
               
                 SCML2 
                 Isoform 1 of Sex comb  
                 IPI:IPI00328688.3 
                 LDGSDNR 
                 0.32 
                 0.69 
                 0.46 
               
               
                   
                 on midleg-like  
                   
                   
                   
                   
                   
               
               
                   
                 protein 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SELENBP1 
                 Selenium-binding  
                 IPI:IPI00012303.2 
                 HNVMISTEWAAPNVLR 
                 0.28 
                 0.48 
                 0.58 
               
               
                   
                 protein 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SEMA7A 
                 Semaphorin-7A 
                 IPI:IPI00025257.1 
                 LQDVFLLPDPSGQWR 
                   
                 0.58 
                   
               
               
                   
               
               
                 SEPP1 
                 Selenoprotein P 
                 IPI:IPI00029061.2 
                 LPTDSELAPR 
                 1.51 
                 2.10 
                 0.72 
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 GKWERPFEVK 
                 56.93 
                 25.11 
                 2.27 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 GTEAAGAMFLEAIPM 
                 17.00 
                 7.28 
                 2.33 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 GTEAAGAMFLEAIPM 
                 0.42 
                   
                   
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 KLSSWVLLMK 
                 49.95 
                 17.92 
                 2.79 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 KLSSWVLLMK 
                 2.15 
                 0.89 
                 2.42 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 KQINDYVEKGTQGK 
                   
                 0.59 
                   
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 LAEFAFSLYR 
                 12.97 
                 5.48 
                 2.37 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 LYHSEAFTVNFGDTEEAKK 
                   
                 6.55 
                   
               
               
                   
                 antitrypsin 
                   
                 QINDYVEK 
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 PFVFLMIEQNTK 
                 0.43 
                   
                   
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA1 
                 Isoform 1 of Alpha-1- 
                 IPI:IPI00553177.1 
                 TVNFGDTEEAKK 
                 1.01 
                 1.16 
                 0.86 
               
               
                   
                 antitrypsin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA10 
                 Protein Z-dependent 
                 IPI:IPI00007199.4 
                 NMEVFFPK 
                 0.27 
                   
                   
               
               
                   
                 protease inhibitor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINA3 
                 Alpha-l-antichymotrypsin 
                 IPI:IPI00550991.3 
                 FEEGTEASAATAVK 
                 0.48 
                   
                   
               
               
                   
               
               
                 SERPINA3 
                 Alpha-l-antichymotrypsin 
                 IPI:IPI00550991.3 
                 IIVPTDTQNIFFMSK 
                 1.20 
                 1.08 
                 1.11 
               
               
                   
               
               
                 SERPINA3 
                 Alpha-l-antichymotrypsin 
                 IPI:IPI00550991.3 
                 PFDPQDTHQSR 
                 1.66 
                 0.62 
                 2.66 
               
               
                   
               
               
                 SERPINA3 
                 Alpha-l-antichymotrypsin 
                 IPI:IPI00550991.3 
                 WVMVPMMSLHHLTIPYFR 
                 0.44 
                   
                   
               
               
                   
               
               
                 SERPINA4 
                 Kallistatin 
                 IPI:IPI00328609.3 
                 ATLDVDEAGTEAAAATSFAI 
                 0.47 
                 0.48 
                 1.00 
               
               
                   
                   
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 SERPINA4 
                 Kallistatin 
                 IPI:IPI00328609.3 
                 FYYLIASETPGK 
                 1.57 
                 1.70 
                 0.93 
               
               
                   
               
               
                 SERPINA4 
                 Kallistatin 
                 IPI:IPI00328609.3 
                 LGFTDLFSK 
                 3.25 
                 5.05 
                 0.64 
               
               
                   
               
               
                 SERPINA4 
                 Kallistatin 
                 IPI:IPI00328609.3 
                 WADLSGITK 
                 1.79 
                 1.91 
                 0.94 
               
               
                   
               
               
                 SERPINA7 
                 Thyroxine-binding 
                 IPI:IPI00292946.1 
                 FAFNLYR 
                 7.38 
                 10.02 
                 0.74 
               
               
                   
                 globulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINC1 
                 SERPINC1 protein 
                 IPI:IPI00844156.2 
                 FATTFYQHLADSKNDNDNIF 
                   
                 0.21 
                   
               
               
                   
                   
                   
                 LSPLSISTAFAMTK 
                   
                   
                   
               
               
                   
               
               
                 SERPINC1 
                 Antithrombin III  
                 IPI:IPI00032179.2 
                 FATTFYQHLADSKNDNDNIF 
                   
                 0.21 
                   
               
               
                   
                 variant 
                   
                 LSPLSISTAFAMTK 
                   
                   
                   
               
               
                   
               
               
                 SERPINC1 
                 SERPINC1 protein 
                 IPI:IPI00844156.2 
                 LVSANR 
                 5.73 
                 8.06 
                 0.71 
               
               
                   
               
               
                 SERPINC1 
                 Antithrombin III  
                 IPI:IPI00032179.2 
                 LVSANR 
                 5.73 
                 8.06 
                 0.71 
               
               
                   
                 variant 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINC1 
                 SERPINC1 protein 
                 IPI:IPI00844156.2 
                 RVWELSK 
                 36.77 
                 46.37 
                 0.79 
               
               
                   
               
               
                 SERPINC1 
                 Antithrombin III  
                 IPI:IPI00032179.2 
                 RVWELSK 
                 36.77 
                 46.37 
                 0.79 
               
               
                   
                 variant 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINC1 
                 Antithrombin III  
                 IPI:IPI00032179.2 
                 VAEGTQVLELPFKGDDITM 
                 0.59 
                 1.01 
                 0.58 
               
               
                   
                 variant 
                   
                 VLILPKPEK 
                   
                   
                   
               
               
                   
               
               
                 SERPIND1 
                 Serpin peptidase  
                 IPI:IPI00292950.4 
                 FAFNLYR 
                 7.38 
                 10.02 
                 0.74 
               
               
                   
                 inhibitor, 
                   
                   
                   
                   
                   
               
               
                   
                 clade D (Heparin  
                   
                   
                   
                   
                   
               
               
                   
                 cofactor), member 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPIND1 
                 Serpin peptidase  
                 IPI:IPI00292950.4 
                 SVNDLYIQK 
                 9.13 
                 12.01 
                 0.76 
               
               
                   
                 inhibitor, 
                   
                   
                   
                   
                   
               
               
                   
                 clade D (Heparin  
                   
                   
                   
                   
                   
               
               
                   
                 cofactor), member 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINF1 
                 Pigment epithelium- 
                 IPI:IPI00006114.4 
                 LQSLFDSPDFSK 
                 8.16 
                 11.20 
                 0.73 
               
               
                   
                 derived factor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINF1 
                 Pigment epithelium- 
                 IPI:IPI00006114.4 
                 TVQAVLTVPK 
                 5.46 
                 7.34 
                 0.74 
               
               
                   
                 derived factor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINF1 
                 Pigment epithelium- 
                 IPI:IPI00006114.4 
                 TVRVPMMSDPK 
                 0.27 
                 0.48 
                 0.57 
               
               
                   
                 derived factor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPINF2 
                 Alpha-2-antiplasmin 
                 IPI:IPI00879231.1 
                 DFLQSLK 
                 0.81 
                 1.36 
                 0.60 
               
               
                   
               
               
                 SERPINF2 
                 Alpha-2-antiplasmin 
                 IPI:IPI00879231.1 
                 GDKLFGPDLK 
                 14.71 
                 59.89 
                 0.25 
               
               
                   
               
               
                 SERPINF2 
                 Alpha-2-antiplasmin 
                 IPI:IPI00879231.1 
                 IQEFLSGLPEDTVLLLLNAIH 
                 1.79 
                 2.33 
                 0.77 
               
               
                   
                   
                   
                 FQGFWR 
                   
                   
                   
               
               
                   
               
               
                 SERPING1 
                 Plasma protease C1 
                 IPI:IPI00291866.5 
                 MEPFHFKNSVIKVPMMNSK 
                 0.32 
                 0.62 
                 0.52 
               
               
                   
                 inhibitor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPING1 
                 Plasma protease C1 
                 IPI:IPI00291866.5 
                 PVAHFIDQTLK 
                 0.70 
                   
                   
               
               
                   
                 inhibitor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SERPING1 
                 Plasma protease C1 
                 IPI:IPI00291866.5 
                 VATTVISK 
                 0.99 
                 1.68 
                 0.59 
               
               
                   
                 inhibitor 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SH3BGRL2 
                 SH3 domain-binding 
                 IPI:IPI00412272.2 
                 ESNTVFSFLGLKPR 
                 0.89 
                   
                   
               
               
                   
                 glutamic acid-rich-like 
                   
                   
                   
                   
                   
               
               
                   
                 protein 2 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SH3BGRL3 
                 SH3 domain-binding 
                 IPI:IPI00746352.1 
                 VYSTSVTGSR 
                 0.25 
                 0.22 
                 1.14 
               
               
                   
                 glutamic acid-rich-like 
                   
                   
                   
                   
                   
               
               
                   
                 protein 3 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SHBG 
                 Isoform 1 of Sex  
                 IPI:IPI00023019.1 
                 IALGGLLFPASNLR 
                 0.81 
                 1.62 
                 0.50 
               
               
                   
                 hormone-binding  
                   
                   
                   
                   
                   
               
               
                   
                 globulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SHBG 
                 Isoform 1 of Sex  
                 IPI:IPI00023019.1 
                 TSSSFEVR 
                 0.16 
                 0.39 
                 0.42 
               
               
                   
                 hormone-binding  
                   
                   
                   
                   
                   
               
               
                   
                 globulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SHBG 
                 Isoform 1 of Sex  
                 IPI:IPI00023019.1 
                 VVLSSGSGPGLDLPLVLGLP 
                 0.41 
                 0.97 
                 0.42 
               
               
                   
                 hormone-binding  
                   
                 LQLK 
                   
                   
                   
               
               
                   
                 globulin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SLC14A2 
                 Urea transporter,  
                 IPI:IPI00177820.3 
                 ASIITK 
                 0.72 
                 0.95 
                 0.75 
               
               
                   
                 kidney 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SLC9A6 
                 Sodium/hydrogen 
                 IPI:IPI00022061.5 
                 LLNLGR 
                   
                 0.43 
                   
               
               
                   
                 exchanger 6 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SMG7 
                 Breast cancer-associated 
                 IPI:IPI00871896.1 
                 MSFLGILCK 
                 0.16 
                 0.14 
                 1.17 
               
               
                   
                 antigen SGA-56M 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 SVIL 
                 Isoform 2 of  
                 IPI:IPI00018370.3 
                 RSRNTAVEQRLR 
                 0.50 
                   
                   
               
               
                   
                 Supervillin 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 TAGLN2 
                 Transgelin-2 
                 IPI:IPI00550363.3 
                 DVGRPQPGRENFQNWLK 
                   
                 0.27 
                   
               
               
                   
               
               
                 TAOK1 
                 Isoform 1 of 
                 IPI:IPI00002232.2 
                 VSLRRALLEQK 
                 7.19 
                 9.27 
                 0.78 
               
               
                   
                 Serine/threonine-protein 
                   
                   
                   
                   
                   
               
               
                   
                 kinase TAO1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 TEGT 
                 Bax inhibitor 1 
                 IPI:IPI00022748.4 
                 KLMMILAMNEKDK 
                   
                 0.25 
                   
               
               
                   
               
               
                 TF 
                 Serotransferrin 
                 IPI:IPI00022463.1 
                 HQTVPQNTGGK 
                 1.02 
                   
                   
               
               
                   
               
               
                 TF 
                 Serotransferrin 
                 IPI:IPI00022463.1 
                 SDNCEDTPEAGYFAVAVVK 
                 1.38 
                   
                   
               
               
                   
                   
                   
                 K 
                   
                   
                   
               
               
                   
               
               
                 TF 
                 Serotransferrin 
                 IPI:IPI00022463.1 
                 YLGEEYVK 
                 4.05 
                   
                   
               
               
                   
               
               
                 THBS1 
                 Thrombospondin-1 
                 IPI:IPI00296099.6 
                 DLASIAR 
                 0.57 
                 5.76 
                 0.10 
               
               
                   
               
               
                 THBS1 
                 Thrombospondin-1 
                 IPI:IPI00296099.6 
                 FVFGTTPEDILR 
                 1.87 
                 1.11 
                 1.68 
               
               
                   
               
               
                 THBS1 
                 Thrombospondin-1 
                 IPI:IPI00296099.6 
                 GTLLALERK 
                 0.58 
                 0.95 
                 0.61 
               
               
                   
               
               
                 TIMP1 
                 Metalloproteinase  
                 IPI:IPI00032292.1 
                 HLACLPR 
                 0.39 
                 3.64 
                 0.11 
               
               
                   
                 inhibitor 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 TKT 
                 Transketolase 
                 IPI:IPI00643920.2 
                 MFGIDRDAIAQAVR 
                 0.73 
                   
                   
               
               
                   
               
               
                 TLN1 
                 Talin-1 
                 IPI:IPI00298994.6 
                 ALSTDPAAPNLK 
                 2.29 
                 0.50 
                 4.58 
               
               
                   
               
               
                 TLN1 
                 Talin-1 
                 IPI:IPI00298994.6 
                 AVASAAAALVLK 
                 0.91 
                 0.36 
                 2.56 
               
               
                   
               
               
                 TLN1 
                 Talin-1 
                 IPI:IPI00298994.6 
                 LASEAKPAAVAAENEEIGSH 
                 0.91 
                   
                   
               
               
                   
                   
                   
                 IK 
                   
                   
                   
               
               
                   
               
               
                 TLN1 
                 Talin-1 
                 IPI:IPI00298994.6 
                 VLVQNAAGSQEK 
                 0.64 
                 0.29 
                 2.24 
               
               
                   
               
               
                 TLN1 
                 Talin-1 
                 IPI:IPI00298994.6 
                 VMVTNVTSLLK 
                 1.81 
                 0.82 
                 2.21 
               
               
                   
               
               
                 TNC 
                 Isoform 1 of Tenascin 
                 IPI:IPI00031008.1 
                 KQSEPLEITLLAPER 
                 3.50 
                 33.66 
                 0.10 
               
               
                   
               
               
                 TPM2 
                 Tropomyosin 2 
                 IPI:IPI00513698.1 
                 IQLVEEELDRAQER 
                 0.63 
                 0.30 
                 2.10 
               
               
                   
               
               
                 TTR 
                 Transthyretin 
                 IPI:IPI00022432.1 
                 AADDTWEPFASGK 
                 84.06 
                 151.87 
                 0.55 
               
               
                   
               
               
                 TTR 
                 Transthyretin 
                 IPI:IPI00022432.1 
                 ADDTWEPFASGK 
                 0.29 
                 0.48 
                 0.60 
               
               
                   
               
               
                 UBA1 
                 Ubiquitin-like modifier- 
                 IPI:IPI00645078.1 
                 KPLLESGTLGTK 
                   
                 0.42 
                   
               
               
                   
                 activating enzyme 1 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 UBE2L3 
                 Ubiquitin-conjugating 
                 IPI:IPI00021347.1 
                 TDQVIQSLIALVNDPQPEHPL 
                 34.09 
                   
                   
               
               
                   
                 enzyme E2 L3 
                   
                 R 
                   
                   
                   
               
               
                   
               
               
                 VASN 
                 Vasorin 
                 IPI:IPI00395488.2 
                 YLQGSSVQLR 
                   
                 0.21 
                   
               
               
                   
               
               
                 VCL 
                 Isoform 1 of Vinculin 
                 IPI:IPI00291175.7 
                 AQQVSQGLDVLTAK 
                 0.81 
                 0.38 
                 2.14 
               
               
                   
               
               
                 VCL 
                 Isoform 1 of Vinculin 
                 IPI:IPI00291175.7 
                 MSAEINEIIR 
                 0.33 
                 0.55 
                 0.60 
               
               
                   
               
               
                 VNN1 
                 Pantetheinase 
                 IPI:IPI00030871.2 
                 AFHYDMK 
                 0.63 
                   
                   
               
               
                   
               
               
                 VTN 
                 Vitronectin 
                 IPI:IPI00298971.1 
                 GQYCYELDEK 
                   
                 0.32 
                   
               
               
                   
               
               
                 VTN 
                 Vitronectin 
                 IPI:IPI00298971.1 
                 LIRDVWGIEGPIDAAFTR 
                   
                 0.74 
                   
               
               
                   
               
               
                 VWF 
                 von Willebrand factor 
                 IPI:IPI00023014.1 
                 HIVTFDGQNFK 
                 1.08 
                 0.70 
                 1.55 
               
               
                   
               
               
                 VWF 
                 von Willebrand factor 
                 IPI:IPI00023014.1 
                 VIVIPVGIGPHANLK 
                 0.92 
                 0.62 
                 1.50 
               
               
                   
               
               
                 VWF 
                 von Willebrand factor 
                 IPI:IPI00023014.1 
                 YIILLLGK 
                 0.51 
                   
                   
               
               
                   
               
               
                 YWHAB 
                 Isoform Short of 14-3-3 
                 IPI:IPI00759832.1 
                 YDDMAAAMK 
                 0.25 
                   
                   
               
               
                   
                 protein beta/alpha 
                   
                   
                   
                   
                   
               
               
                   
               
               
                 YWHAG 
                 14-3-3 protein gamma 
                 IPI:IPI00220642.7 
                 YDDMAAAMK 
                 0.25 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE S2 
               
             
             
               
                   
               
               
                 Identified significant proteins 
               
             
          
           
               
                   
                   
                   
                   
                 Average 
                 Average 
                 Ratio HL 
               
               
                 GENE 
                   
                 #peptides/ 
                   
                 HL 
                 HL 
                 positive/HL 
               
               
                 SYMBOL 
                 Description 
                 protein 
                 Reference 
                 positive 
                 negative 
                 negative 
               
               
                   
               
             
          
           
               
                 A1BG 
                 Alpha-1B-glycoprotein precursor 
                 27 
                 IPI: IPI00022895.7 
                 23.54 
                 24.48 
                 0.96 
               
               
                 ACTA1 
                 Actin, alpha skeletal muscle 
                 19 
                 IPI: IPI00021428.1 
                 3.34 
                 6.23 
                 0.54 
               
               
                 ACTB 
                 Actin, cytoplasmic 1 
                 25 
                 IPI: IPI00021439.1 
                 4.79 
                 4.32 
                 1.11 
               
               
                 ACTN1 
                 Alpha-actinin-1 
                 21 
                 IPI: IPI00013508.5 
                 0.79 
                 0.46 
                 1.70 
               
               
                 AGT 
                 Angiotensinogen precursor 
                 23 
                 IPI: IPI00032220.3 
                 7.24 
                 9.55 
                 0.76 
               
               
                 AHSG 
                 Alpha-2-HS-glycoprotein precursor 
                 11 
                 IPI: IPI00022431.1 
                 27.46 
                 16.07 
                 1.71 
               
               
                 AMBP 
                 AMBP protein precursor 
                 6 
                 IPI: IPI00022426.1 
                 7.03 
                 15.78 
                 0.45 
               
               
                 ANPEP 
                 Aminopeptidase N 
                 5 
                 IPI: IPI00221224.6 
                 0.59 
                 0.74 
                 0.80 
               
               
                 APOA4 
                 Apolipoprotein A-IV precursor 
                 42 
                 IPI: IPI00304273.2 
                 4.36 
                 4.16 
                 1.05 
               
               
                 APOB 
                 Apolipoprotein B-100 precursor 
                 320 
                 IPI: IPI00022229.1 
                 8.33 
                 8.67 
                 0.96 
               
               
                 APOC1 
                 Apolipoprotein C-I precursor 
                 6 
                 IPI: IPI00021855.1 
                 1.75 
                 0.35 
                 5.04 
               
               
                 APOC2 
                 Apolipoprotein C-II precursor 
                 9 
                 IPI: IPI00021856.3 
                 4.94 
                 2.50 
                 1.97 
               
               
                 APOC3 
                 Apolipoprotein C-III precursor 
                 9 
                 IPI: IPI00021857.1 
                 3.58 
                 2.86 
                 1.25 
               
               
                 APOE 
                 Apolipoprotein E precursor 
                 25 
                 IPI: IPI00021842.1 
                 3.79 
                 1.83 
                 2.07 
               
               
                 APOF 
                 apolipoprotein F precursor 
                 2 
                 IPI: IPI00299435.3 
                 1.38 
                 0.36 
                 3.85 
               
               
                 APOH 
                 Beta-2-glycoprotein 1 precursor 
                 7 
                 IPI: IPI00298828.3 
                 17.52 
                 14.91 
                 1.18 
               
               
                 APOL1 
                 42 kDa protein 
                 9 
                 IPI: IPI00852826.2 
                 0.58 
                 0.71 
                 0.81 
               
               
                 APOM 
                 Apolipoprotein M 
                 3 
                 IPI: IPI00030739.1 
                 2.25 
                 1.51 
                 1.49 
               
               
                 ARHGDIB 
                 Rho GDP-dissociation inhibitor 2 
                 4 
                 IPI: IPI00003817.3 
                 0.28 
                 2.06 
                 0.13 
               
               
                 ASL 
                 Argininosuccinate lyase 
                 2 
                 IPI: IPI00220267.7 
                 0.36 
                 0.58 
                 0.62 
               
               
                 AZGP1 
                 alpha-2-glycoprotein 1, zinc 
                 15 
                 IPI: IPI00166729.4 
                 7.06 
                 11.59 
                 0.61 
               
               
                 B2M 
                 Beta-2-microglobulin 
                 5 
                 IPI: IPI00868938.1 
                 1.08 
                 1.77 
                 0.61 
               
               
                 BCHE 
                 Cholinesterase precursor 
                 13 
                 IPI: IPI00025864.5 
                 1.06 
                 0.67 
                 1.58 
               
               
                 BLVRB 
                 Flavin reductase 
                 2 
                 IPI: IPI00783862.2 
                 0.39 
                 0.51 
                 0.76 
               
               
                 BTD 
                 biotinidase precursor 
                 8 
                 IPI: IPI00218413.2 
                 0.67 
                 0.88 
                 0.77 
               
               
                 C1QA 
                 Complement C1q subcomponent subunit A 
                 3 
                 IPI: IPI00022392.1 
                 1.03 
                 1.17 
                 0.88 
               
               
                   
                 precursor 
               
               
                 C1QB 
                 complement component 1, q subcomponent, 
                 5 
                 IPI: IPI00477992.1 
                 0.96 
                 0.66 
                 1.47 
               
               
                   
                 B chain precursor 
               
               
                 C1R 
                 Complement C1r subcomponent precursor 
                 13 
                 IPI: IPI00296165.5 
                 1.02 
                 0.90 
                 1.13 
               
               
                 C1RL 
                 Complement C1r-like protein 
                 9 
                 IPI: IPI00009793.3 
                 0.32 
                 0.40 
                 0.80 
               
               
                 C1S 
                 Complement C1s subcomponent precursor 
                 18 
                 IPI: IPI00017696.1 
                 1.09 
                 1.21 
                 0.91 
               
               
                 C2 
                 Complement C2 precursor (Fragment) 
                 27 
                 IPI: IPI00303963.1 
                 1.64 
                 1.45 
                 1.13 
               
               
                 C3 
                 Complement C3 precursor (Fragment) 
                 216 
                 IPI: IPI00783987.2 
                 16.75 
                 16.37 
                 1.02 
               
               
                 C4A 
                 Complement component 4A 
                 126 
                 IPI: IPI00643525.1 
                 13.88 
                 10.76 
                 1.29 
               
               
                 C4B 
                 C4B1 
                 128 
                 IPI: IPI00418163.3 
                 18.80 
                 12.78 
                 1.47 
               
               
                 C4BPA 
                 C4b-binding protein alpha chain precursor 
                 9 
                 IPI: IPI00021727.1 
                 0.52 
                 0.48 
                 1.08 
               
               
                 C5 
                 Complement C5 precursor 
                 76 
                 IPI: IPI00032291.2 
                 2.48 
                 2.95 
                 0.84 
               
               
                 C6 
                 Complement component 6 precursor 
                 25 
                 IPI: IPI00009920.2 
                 1.08 
                 1.29 
                 0.84 
               
               
                 C7 
                 Complement component C7 precursor 
                 21 
                 IPI: IPI00296608.6 
                 1.36 
                 1.48 
                 0.92 
               
               
                 C8A 
                 Complement component C8 alpha chain 
                 18 
                 IPI: IPI00011252.1 
                 1.72 
                 2.91 
                 0.59 
               
               
                   
                 precursor 
               
               
                 C8B 
                 Complement component C8 beta chain 
                 18 
                 IPI: IPI00294395.1 
                 2.12 
                 1.95 
                 1.09 
               
               
                   
                 precursor 
               
               
                 C9 
                 Complement component C9 precursor 
                 24 
                 IPI: IPI00022395.1 
                 3.44 
                 3.14 
                 1.10 
               
               
                 CA1 
                 Carbonic anhydrase 1 
                 6 
                 IPI: IPI00215983.3 
                 1.32 
                 1.21 
                 1.09 
               
               
                 CD14 
                 Monocyte differentiation antigen CD14 
                 7 
                 IPI: IPI00029260.2 
                 0.39 
                 0.27 
                 1.46 
               
               
                   
                 precursor 
               
               
                 CDH5 
                 Cadherin-5 precursor 
                 2 
                 IPI: IPI00012792.1 
                 0.37 
                 0.27 
                 1.39 
               
               
                 CECR1 
                 Cat eye syndrome critical region protein 1 
                 2 
                 IPI: IPI00303071.4 
                 5.31 
                 0.63 
                 8.40 
               
               
                   
                 precursor 
               
               
                 CFB 
                 Isoform 1 of Complement factor B precursor 
                 43 
                 IPI: IPI00019591.1 
                 10.49 
                 9.81 
                 1.07 
               
               
                   
                 (Fragment) 
               
               
                 CFD 
                 Complement factor D preproprotein 
                 4 
                 IPI: IPI00165972.3 
                 0.28 
                 1.40 
                 0.20 
               
               
                 CFH 
                 Isoform 1 of Complement factor H precursor 
                 28 
                 IPI: IPI00029739.5 
                 4.04 
                 4.34 
                 0.93 
               
               
                 CFI 
                 Complement factor I precursor 
                 13 
                 IPI: IPI00291867.3 
                 2.04 
                 2.55 
                 0.80 
               
               
                 CFL1 
                 Cofilin-1 
                 6 
                 IPI: IPI00012011.6 
                 0.51 
                 0.51 
                 1.00 
               
               
                 CLEC3B 
                 Tetranectin precursor 
                 6 
                 IPI: IPI00009028.1 
                 1.26 
                 1.01 
                 1.26 
               
               
                 CNDP1 
                 Beta-Ala-His dipeptidase precursor 
                 21 
                 IPI: IPI00064667.4 
                 0.44 
                 0.44 
                 1.00 
               
               
                 CNTN1 
                 Isoform 1 of Contactin-1 precursor 
                 2 
                 IPI: IPI00029751.1 
                 1.15 
                 0.49 
                 2.36 
               
               
                 COL6A3 
                 alpha 3 type VI collagen isoform 1 precursor 
                 3 
                 IPI: IPI00022200.2 
                 0.58 
                 24.55 
                 0.02 
               
               
                 CP 
                 Ceruloplasmin precursor 
                 78 
                 IPI: IPI00017601.1 
                 6.40 
                 6.07 
                 1.05 
               
               
                 CPB2 
                 Isoform 1 of Carboxypeptidase B2 precursor 
                 13 
                 IPI: IPI00329775.7 
                 0.71 
                 0.83 
                 0.85 
               
               
                 CPN1 
                 Carboxypeptidase N catalytic chain 
                 10 
                 IPI: IPI00010295.1 
                 0.54 
                 0.65 
                 0.83 
               
               
                   
                 precursor 
               
               
                 CPN2 
                 similar to Carboxypeptidase N subunit 2 
                 14 
                 IPI: IPI00738433.1 
                 1.43 
                 1.60 
                 0.89 
               
               
                   
                 precursor 
               
               
                 CRP 
                 Isoform 1 of C-reactive protein precursor 
                 9 
                 IPI: IPI00022389.1 
                 15.24 
                 3.24 
                 4.71 
               
               
                 CST3 
                 Cystatin-C precursor 
                 3 
                 IPI: IPI00032293.1 
                 1.64 
                 1.04 
                 1.57 
               
               
                 ECM1 
                 Extracellular matrix protein 1 
                 10 
                 IPI: IPI00645849.1 
                 0.36 
                 0.38 
                 0.93 
               
               
                 EFEMP1 
                 Isoform 1 of EGF-containing fibulin-like 
                 4 
                 IPI: IPI00029658.1 
                 0.21 
                 0.41 
                 0.53 
               
               
                   
                 extracellular matrix protein 1 precursor 
               
               
                 F10 
                 Coagulation factor X precursor 
                 9 
                 IPI: IPI00019576.1 
                 0.82 
                 1.19 
                 0.69 
               
               
                 F11 
                 Isoform 1 of Coagulation factor XI 
                 8 
                 IPI: IPI00008556.1 
                 0.24 
                 0.26 
                 0.93 
               
               
                   
                 precursor 
               
               
                 F2 
                 Prothrombin precursor (Fragment) 
                 20 
                 IPI: IPI00019568.1 
                 6.98 
                 6.10 
                 1.14 
               
               
                 F5 
                 Coagulation factor V 
                 14 
                 IPI: IPI00022937.4 
                 0.42 
                 0.34 
                 1.26 
               
               
                 FCGBP 
                 IgGFc-binding protein precursor 
                 4 
                 IPI: IPI00242956.4 
                 1.88 
                 1.55 
                 1.21 
               
               
                 FCN3 
                 Isoform 1 of Ficolin-3 precursor 
                 9 
                 IPI: IPI00293925.2 
                 3.78 
                 4.00 
                 0.94 
               
               
                 FGA 
                 Isoform 1 of Fibrinogen alpha chain 
                 41 
                 IPI: IPI00021885.1 
                 2.55 
                 0.96 
                 2.65 
               
               
                   
                 precursor 
               
               
                 FLNA 
                 filamin A, alpha isoform 1 
                 48 
                 IPI: IPI00302592.2 
                 0.51 
                 0.42 
                 1.22 
               
               
                 FN1 
                 Isoform 1 of Fibronectin precursor 
                 19 
                 IPI: IPI00022418.1 
                 0.37 
                 0.40 
                 0.93 
               
               
                 GAPDH 
                 Glyceraldehyde-3-phosphate dehydrogenase 
                 7 
                 IPI: IPI00219018.7 
                 0.93 
                 1.06 
                 0.88 
               
               
                 GC 
                 Vitamin D-binding protein precursor 
                 32 
                 IPI: IPI00555812.4 
                 13.45 
                 10.90 
                 1.23 
               
               
                 GGH 
                 Gamma-glutamyl hydrolase precursor 
                 4 
                 IPI: IPI00023728.1 
                 5.74 
                 4.71 
                 1.22 
               
               
                 GP1BA 
                 platelet glycoprotein Ib alpha polypeptide 
                 5 
                 IPI: IPI00748955.2 
                 0.52 
                 0.67 
                 0.78 
               
               
                   
                 precursor 
               
               
                 GPLD1 
                 Isoform 1 of Phosphatidylinositol-glycan- 
                 11 
                 IPI: IPI00299503.2 
                 2.04 
                 0.35 
                 5.77 
               
               
                   
                 specific phospholipase D precursor 
               
               
                 GSN 
                 Isoform 1 of Gelsolin precursor 
                 44 
                 IPI: IPI00026314.1 
                 1.64 
                 2.84 
                 0.58 
               
               
                 HBA2 
                 Hemoglobin subunit alpha 
                 9 
                 IPI: IPI00410714.5 
                 4.71 
                 4.25 
                 1.11 
               
               
                 HGFAC 
                 Hepatocyte growth factor activator precursor 
                 5 
                 IPI: IPI00029193.1 
                 0.42 
                 0.42 
                 1.01 
               
               
                 HPR 
                 Isoform 1 of Haptoglobin-related protein 
                 15 
                 IPI: IPI00477597.1 
                 1.73 
                 1.72 
                 1.01 
               
               
                   
                 precursor 
               
               
                 HPX 
                 Hemopexin precursor 
                 39 
                 IPI: IPI00022488.1 
                 12.50 
                 13.53 
                 0.92 
               
               
                 HRG 
                 Histidine-rich glycoprotein precursor 
                 21 
                 IPI: IPI00022371.1 
                 7.89 
                 9.94 
                 0.79 
               
               
                 HSPA8 
                 Heat shock 70 kDa protein 8 isoform 2 
                 7 
                 IPI: IPI00795040.1 
                 0.50 
                 0.52 
                 0.98 
               
               
                   
                 variant (Fragment) 
               
               
                 ICAM1 
                 Intercellular adhesion molecule 1 precursor 
                 3 
                 IPI: IPI00008494.4 
                 0.80 
                 0.62 
                 1.28 
               
               
                 IGFALS 
                 Insulin-like growth factor-binding protein 
                 20 
                 IPI: IPI00020996.3 
                 1.01 
                 1.12 
                 0.90 
               
               
                   
                 complex acid labile chain precursor 
               
               
                 IGFBP2 
                 Insulin-like growth factor-binding protein 2 
                 2 
                 IPI: IPI00297284.1 
                 0.28 
                 0.17 
                 1.68 
               
               
                   
                 precursor 
               
               
                 IGFBP6 
                 Insulin-like growth factor-binding protein 6 
                 2 
                 IPI: IPI00029235.1 
                 0.26 
                 0.25 
                 1.04 
               
               
                   
                 precursor 
               
               
                 ITIH1 
                 Inter-alpha-trypsin inhibitor heavy chain H1 
                 38 
                 IPI: IPI00292530.1 
                 4.28 
                 5.84 
                 0.73 
               
               
                   
                 precursor 
               
               
                 ITIH2 
                 Inter-alpha-trypsin inhibitor heavy chain H2 
                 62 
                 IPI: IPI00305461.2 
                 5.39 
                 7.95 
                 0.68 
               
               
                   
                 precursor 
               
               
                 ITIH3 
                 Isoform 1 of Inter-alpha-trypsin inhibitor 
                 28 
                 IPI: IPI00028413.8 
                 1.91 
                 2.41 
                 0.79 
               
               
                   
                 heavy chain H3 precursor 
               
               
                 ITIH4 
                 Isoform 1 of Inter-alpha-trypsin inhibitor 
                 53 
                 IPI: IPI00294193.4 
                 8.60 
                 8.89 
                 0.97 
               
               
                   
                 heavy chain H4 precursor 
               
               
                 KLKB1 
                 Plasma kallikrein precursor 
                 16 
                 IPI: IPI00654888.4 
                 1.73 
                 1.99 
                 0.87 
               
               
                 KNG1 
                 Kininogen-1 
                 16 
                 IPI: IPI00032328.2 
                 17.24 
                 21.46 
                 0.80 
               
               
                 KRT10 
                 Keratin, type I cytoskeletal 10 
                 9 
                 IPI: IPI00009865.2 
                 1.72 
                 2.67 
                 0.64 
               
               
                 KRT2 
                 Keratin, type II cytoskeletal 2 epidermal 
                 4 
                 IPI: IPI00021304.1 
                 2.87 
                 1.05 
                 2.74 
               
               
                 LBP 
                 Lipopolysaccharide-binding protein 
                 8 
                 IPI: IPI00032311.4 
                 0.54 
                 0.42 
                 1.29 
               
               
                   
                 precursor 
               
               
                 LCP1 
                 Plastin-2 
                 7 
                 IPI: IPI00010471.5 
                 0.31 
                 0.25 
                 1.24 
               
               
                 LDHB 
                 L-lactate dehydrogenase B chain 
                 9 
                 IPI: IPI00219217.3 
                 1.92 
                 0.92 
                 2.08 
               
               
                 LPA 
                 Apolipoprotein 
                 11 
                 IPI: IPI00029168.1 
                 0.44 
                 0.61 
                 0.72 
               
               
                 LRG1 
                 Leucine-rich alpha-2-glycoprotein precursor 
                 12 
                 IPI: IPI00022417.4 
                 15.44 
                 11.60 
                 1.33 
               
               
                 LUM 
                 Lumican precursor 
                 11 
                 IPI: IPI00020986.2 
                 1.82 
                 4.43 
                 0.41 
               
               
                 MASP1 
                 mannan-binding lectin serine protease 1 
                 5 
                 IPI: IPI00290283.6 
                 0.25 
                 0.43 
                 0.57 
               
               
                   
                 isoform 2 precursor 
               
               
                 MBL2 
                 Mannose-binding protein C precursor 
                 5 
                 IPI: IPI00004373.1 
                 1.26 
                 0.43 
                 2.97 
               
               
                 MCAM 
                 Isoform 1 of Cell surface glycoprotein 
                 2 
                 IPI: IPI00016334.2 
                 2.49 
                 1.39 
                 1.79 
               
               
                   
                 MUC18 precursor 
               
               
                 MSN 
                 Moesin 
                 4 
                 IPI: IPI00219365.3 
                 1.90 
                 0.62 
                 3.07 
               
               
                 MTMR15 
                 Isoform 1 of Coiled-coil domain-containing 
                 2 
                 IPI: IPI00007317.4 
                 9.30 
                 8.88 
                 1.05 
               
               
                   
                 protein MTMR15 
               
               
                 PCYOX1 
                 Prenylcysteine oxidase 1 precursor 
                 2 
                 IPI: IPI00384280.5 
                 0.19 
                 0.21 
                 0.90 
               
               
                 PDIA3 
                 Protein disulfide-isomerase A3 precursor 
                 4 
                 IPI: IPI00025252.1 
                 0.27 
                 0.40 
                 0.68 
               
               
                 PFN1 
                 Profilin-1 
                 9 
                 IPI: IPI00216691.5 
                 1.12 
                 1.38 
                 0.81 
               
               
                 PGLYRP2 
                 Isoform 1 of N-acetylmuramoyl-L-alanine 
                 12 
                 IPI: IPI00163207.1 
                 1.19 
                 2.02 
                 0.59 
               
               
                   
                 amidase precursor 
               
               
                 PI16 
                 Isoform 1 of Peptidase inhibitor 16 
                 3 
                 IPI: IPI00301143.5 
                 0.60 
                 0.41 
                 1.48 
               
               
                   
                 precursor 
               
               
                 PLEK 
                 Pleckstrin 
                 5 
                 IPI: IPI00306311.8 
                 0.53 
                 0.52 
                 1.01 
               
               
                 PNP 
                 Purine nucleoside phosphorylase 
                 2 
                 IPI: IPI00871140.1 
                 1.80 
                 3.37 
                 0.53 
               
               
                 PPBP 
                 Platelet basic protein precursor 
                 5 
                 IPI: IPI00022445.1 
                 0.62 
                 0.38 
                 1.63 
               
               
                 PRDX2 
                 Peroxiredoxin-2 
                 4 
                 IPI: IPI00027350.3 
                 0.54 
                 0.71 
                 0.77 
               
               
                 PROZ 
                 Isoform 1 of Vitamin K-dependent protein Z 
                 3 
                 IPI: IPI00027843.1 
                 0.23 
                 0.30 
                 0.76 
               
               
                   
                 precursor 
               
               
                 PTGDS 
                 Prostaglandin-H2 D-isomerase precursor 
                 3 
                 IPI: IPI00013179.1 
                 0.28 
                 4.34 
                 0.06 
               
               
                 PVR 
                 Isoform Beta of Poliovirus receptor 
                 2 
                 IPI: IPI00219425.3 
                 0.09 
                 0.15 
                 0.56 
               
               
                   
                 precursor 
               
               
                 PZP 
                 Pregnancy zone protein precursor 
                 12 
                 IPI: IPI00025426.2 
                 0.55 
                 0.26 
                 2.15 
               
               
                 QSOX1 
                 Isoform 1 of Sulfhydryl oxidase 1 precursor 
                 2 
                 IPI: IPI00003590.2 
                 0.37 
                 0.12 
                 3.13 
               
               
                 RBP4 
                 Plasma retinol-binding protein precursor 
                 10 
                 IPI: IPI00022420.3 
                 8.57 
                 6.59 
                 1.30 
               
               
                 RELN 
                 reelin isoform a 
                 2 
                 IPI: IPI00241562.4 
                 0.84 
                 0.88 
                 0.94 
               
               
                 SAA1 
                 serum amyloid A2 
                 7 
                 IPI: IPI00006146.4 
                 1.45 
                 0.51 
                 2.86 
               
               
                 SAA2 
                 Serum amyloid A protein precursor 
                 8 
                 IPI: IPI00552578.2 
                 3.84 
                 2.19 
                 1.75 
               
               
                 SAA4 
                 Serum amyloid A-4 protein precursor 
                 8 
                 IPI: IPI00019399.1 
                 1.20 
                 0.93 
                 1.29 
               
               
                 SELENBP1 
                 Selenium-binding protein 1 
                 2 
                 IPI: IPI00012303.2 
                 11.85 
                 20.47 
                 0.58 
               
               
                 SEMA7A 
                 Semaphorin-7A precursor 
                 2 
                 IPI: IPI00025257.1 
                 2.02 
                 1.15 
                 1.76 
               
               
                 SEPP1 
                 Selenoprotein P precursor 
                 3 
                 IPI: IPI00029061.2 
                 0.56 
                 0.83 
                 0.67 
               
               
                 SERPINA10 
                 Protein Z-dependent protease inhibitor 
                 9 
                 IPI: IPI00007199.4 
                 0.33 
                 0.29 
                 1.14 
               
               
                   
                 precursor 
               
               
                 SERPINA3 
                 Alpha-1-antichymotrypsin precursor 
                 50 
                 IPI: IPI00550991.3 
                 18.18 
                 16.80 
                 1.08 
               
               
                 SERPINA4 
                 Kallistatin precursor 
                 19 
                 IPI: IPI00328609.3 
                 1.09 
                 1.50 
                 0.73 
               
               
                 SERPINA7 
                 Thyroxine-binding globulin precursor 
                 20 
                 IPI: IPI00292946.1 
                 2.09 
                 1.89 
                 1.11 
               
               
                 SERPINC1 
                 Antithrombin III variant 
                 49 
                 IPI: IPI00032179.2 
                 7.26 
                 7.87 
                 0.92 
               
               
                 SERPINC1 
                 SERPINC1 protein 
                 27 
                 IPI: IPI00844156.2 
                 4.65 
                 4.06 
                 1.14 
               
               
                 SERPIND1 
                 Serpin peptidase inhibitor, clade D (Heparin 
                 22 
                 IPI: IPI00292950.4 
                 5.63 
                 5.30 
                 1.06 
               
               
                   
                 cofactor), member 1 
               
               
                 SERPINF1 
                 Pigment epithelium-derived factor precursor 
                 27 
                 IPI: IPI00006114.4 
                 2.07 
                 2.83 
                 0.73 
               
               
                 SERPINF2 
                 Alpha-2-antiplasmin precursor 
                 24 
                 IPI: IPI00879231.1 
                 6.34 
                 6.17 
                 1.03 
               
               
                 SERPING1 
                 Plasma protease C1 inhibitor precursor 
                 42 
                 IPI: IPI00291866.5 
                 7.43 
                 10.58 
                 0.70 
               
               
                 SHBG 
                 Isoform 1 of Sex hormone-binding globulin 
                 10 
                 IPI: IPI00023019.1 
                 0.33 
                 0.42 
                 0.78 
               
               
                   
                 precursor 
               
               
                 TAGLN2 
                 Transgelin-2 
                 6 
                 IPI: IPI00550363.3 
                 0.42 
                 0.31 
                 1.36 
               
               
                 THBS1 
                 Thrombospondin-1 precursor 
                 18 
                 IPI: IPI00296099.6 
                 0.49 
                 0.37 
                 1.31 
               
               
                 TIMP1 
                 Metalloproteinase inhibitor 1 precursor 
                 2 
                 IPI: IPI00032292.1 
                 0.74 
                 3.51 
                 0.21 
               
               
                 TLN1 
                 Talin-1 
                 40 
                 IPI: IPI00298994.6 
                 0.83 
                 0.39 
                 2.15 
               
               
                 TNC 
                 Isoform 1 of Tenascin precursor 
                 3 
                 IPI: IPI00031008.1 
                 0.91 
                 0.94 
                 0.97 
               
               
                 TPM2 
                 Tropomyosin 2 
                 4 
                 IPI: IPI00513698.1 
                 0.37 
                 0.32 
                 1.17 
               
               
                 TTR 
                 Transthyretin precursor 
                 19 
                 IPI: IPI00022432.1 
                 6.96 
                 9.74 
                 0.71 
               
               
                 VASN 
                 Vasorin precursor 
                 3 
                 IPI: IPI00395488.2 
                 0.25 
                 0.32 
                 0.77 
               
               
                 VCL 
                 Isoform 1 of Vinculin 
                 20 
                 IPI: IPI00291175.7 
                 0.35 
                 0.25 
                 1.40 
               
               
                 VTN 
                 Vitronectin precursor 
                 15 
                 IPI: IPI00298971.1 
                 9.92 
                 10.69 
                 0.93 
               
               
                 VWF 
                 von Willebrand factor precursor 
                 25 
                 IPI: IPI00023014.1 
                 1.34 
                 1.09 
                 1.22 
               
               
                 YWHAB 
                 Isoform Short of 14-3-3 protein beta/alpha 
                 4 
                 IPI: IPI00759832.1 
                 0.28 
                 0.23 
                 1.22 
               
               
                 YWHAG 
                 14-3-3 protein gamma 
                 4 
                 IPI: IPI00220642.7 
                 0.37 
                 0.63 
                 0.59 
               
               
                   
               
             
          
         
       
     
     
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE S3 
               
             
             
               
                   
               
               
                 Significantly altered proteins and related biological functions. 
               
               
                 Peptides were initially identified by mass spectrometry. Selected 
               
               
                 biological functions and expression sites associated with the 
               
               
                 individual proteins were identified by Ingenuity Pathway Analysis (IPA). 
               
             
          
           
               
                   
                 Gene 
                 #pept/ 
                   
                 Biological 
                 Expressed b  in 
               
             
          
           
               
                 Protein 
                 Symbol 
                 protein 
                 Ratio a   
                 Function 
                 Liver 
                 WBC c   
               
               
                   
               
             
          
           
               
                 14-3-3 protein gamma 
                 YWHAG 
                 4 
                 0.59 
                 Cancer 
                   
                 X 
               
               
                 Actin, alpha skeletal muscle 
                 ACTA1 
                 19 
                 0.54 
                   
                 X 
                 X 
               
               
                 Alpha 3 type VI collagen 
                 COL6A3 
                 3 
                 0.02 
                 Cancer 
                 X 
                 X 
               
               
                 Alpha-2-glycoprotein 1, 
                 AZGP1 
                 15 
                 0.61 
                 Cancer 
               
               
                 zinc 
               
               
                 Alpha-2-HS-glycoprotein 
                 AHSG 
                 11 
                 1.71 
                 IR d , Cancer 
                 X 
               
               
                 Alpha-actinin-1 
                 ACTN1 
                 21 
                 1.70 
                   
                   
                 X 
               
               
                 AMBP protein 
                 AMBP 
                 6 
                 0.45 
                 IR, Cancer 
                 X 
               
               
                 Apolipoprotein 
                 LPA 
                 11 
                 0.70 
               
               
                 Apolipoprotein C-I 
                 APOC1 
                 6 
                 5.04 
                 Cancer 
                 X 
                 X 
               
               
                 Apolipoprotein C-II 
                 APOC2 
                 9 
                 1.97 
               
               
                 Apolipoprotein E 
                 APOE 
                 25 
                 2.07 
                 IR, Cancer 
                 X 
               
               
                 apolipoprotein F 
                 APOF 
                 2 
                 3.85 
                 Cancer 
                 X 
               
               
                 Apolipoprotein M 
                 APOM 
                 3 
                 1.50 
                   
                 X 
               
               
                 Argininosuccinate lyase 
                 ASL 
                 2 
                 0.62 
                   
                 X 
               
               
                 Beta-2-microglobulin 
                 B2M 
                 5 
                 0.61 
                 IR, Cancer 
                 X 
                 X 
               
               
                 C4B1 
                 C4B 
                 128 
                 1.50 
                 IR, Cancer 
                 X 
               
               
                 Cat eye syndrome critical 
                 CECR1 
                 2 
                 8.40 
               
               
                 region protein 1 
               
               
                 Cell surface glycoprotein 
                 MCAM 
                 2 
                 1.79 
                 IR, Cancer 
               
               
                 MUC18 
               
               
                 Cholinesterase 
                 BCHE 
                 13 
                 1.58 
               
               
                 Coagulation factor X 
                 F10 
                 9 
                 0.69 
                   
                 X 
               
               
                 Complement component 4A 
                 C4A 
                 126 
                 1.29 
                 IR, Cancer 
                 X 
               
               
                 Complement component C8 
                 C8A 
                 18 
                 0.59 
                 IR 
                 X 
               
               
                 alpha chain 
               
               
                 Complement factor D 
                 CFD 
                 4 
                 0.20 
                 IR, Cancer 
                 X 
               
               
                 preproprotein 
               
               
                 Contactin-1 
                 CNTN1 
                 2 
                 2.36 
               
               
                 C-reactive protein 
                 CRP 
                 9 
                 4.71 
                 IR, Cancer 
                 X 
               
               
                 Cystatin-C 
                 CST3 
                 3 
                 1.57 
                 Cancer 
                   
                 X 
               
               
                 EGF-containing fibulin-like 
                 EFEMP1 
                 4 
                 0.53 
                 Cancer 
                 X 
               
               
                 extracellular matrix protein 1 
               
               
                 Gelsolin 
                 GSN 
                 44 
                 0.58 
                 IR, Cancer 
               
               
                 Insulin-like growth factor- 
                 IGFBP2 
                 2 
                 1.68 
                 Cancer 
                 X 
                 X 
               
               
                 binding protein 2 
               
               
                 Inter-alpha-trypsin inhibitor 
                 ITIH1 
                 38 
                 0.70 
                   
                 X 
               
               
                 heavy chain H1 
               
               
                 Inter-alpha-trypsin inhibitor 
                 ITIH2 
                 62 
                 0.70 
                   
                 X 
               
               
                 heavy chain H2 
               
               
                 Phosphatidylinositol- 
                 GPLD1 
                 11 
                 5.77 
                   
                 X 
               
               
                 glycan-specific 
               
               
                 phospholipase D 
               
               
                 Sulfhydryl oxidase 1 
                 QSOX1 
                 2 
                 3.13 
                   
                   
                 X 
               
               
                 Kallistatin 
                 SERPINA4 
                 19 
                 0.70 
               
               
                 Keratin, type I cytoskeletal 
                 KRT10 
                 9 
                 0.64 
                   
                 X 
                 X 
               
               
                 10 
               
               
                 Keratin, type II cytoskeletal 
                 KRT2 
                 4 
                 2.74 
               
               
                 2 epidermal 
               
               
                 L-lactate dehydrogenase B 
                 LDHB 
                 9 
                 2.08 
                   
                   
                 X 
               
               
                 chain 
               
               
                 Lumican 
                 LUM 
                 11 
                 0.41 
                 IR 
                   
                 X 
               
               
                 Mannan-binding lectin 
                 MASP1 
                 5 
                 0.57 
                 IR, Cancer 
                 X 
               
               
                 serine protease 1 
               
               
                 Mannose-binding protein C 
                 MBL2 
                 5 
                 2.97 
                 IR 
               
               
                 Metalloproteinase inhibitor 1 
                 TIMP1 
                 2 
                 0.21 
                 IR, Cancer 
                 X 
                 X 
               
               
                 Moesin 
                 MSN 
                 4 
                 3.07 
                 IR 
                   
                 X 
               
               
                 Monocyte differentiation 
                 CD14 
                 7 
                 1.5 
                 IR, Cancer 
                   
                 X 
               
               
                 antigen CD14 
               
               
                 Peptidase inhibitor 16 
                 PI16 
                 3 
                 1.50 
                   
                   
                 X 
               
               
                 Pigment epithelium-derived 
                 SERPINF1 
                 27 
                 0.70 
                   
                   
                 X 
               
               
                 factor 
               
               
                 Plasma protease C1 
                 SERPING1 
                 42 
                 0.70 
                   
                 X 
                 X 
               
               
                 inhibitor 
               
               
                 Platelet basic protein 
                 PPBP 
                 5 
                 1.63 
                 IR 
                   
                 X 
               
               
                 Poliovirus receptor 
                 PVR 
                 2 
                 0.56 
                 IR 
                   
                 X 
               
               
                 Pregnancy zone protein 
                 PZP 
                 12 
                 2.15 
               
               
                 Prostaglandin-H2 D- 
                 PTGDS 
                 3 
                 0.06 
                 IR, Cancer 
                 X 
               
               
                 isomerase 
               
               
                 Protein disulfide-isomerase 
                 PDIA3 
                 4 
                 0.68 
                   
                 X 
               
               
                 A3 
               
               
                 Purine nucleoside 
                 PNP 
                 2 
                 0.53 
                 IR, Cancer 
                   
                 X 
               
               
                 phosphorylase 
               
               
                 Rho GDP-dissociation 
                 ARHGDIB 
                 4 
                 0.13 
                 IR, Cancer 
                 X 
                 X 
               
               
                 inhibitor 2 
               
               
                 Selenium-binding protein 1 
                 SELENBP1 
                 2 
                 0.58 
                 Cancer 
               
               
                 Selenoprotein P 
                 SEPP1 
                 3 
                 0.70 
                   
                 X 
                 X 
               
               
                 Semaphorin-7A/CD108 
                 SEMA7A 
                 2 
                 1.76 
                 IR 
                   
                 X 
               
               
                 Serum amyloid A 
                 SAA2 
                 8 
                 1.75 
                   
                 X 
                 X 
               
               
                 Serum amyloid A2 
                 SAA1 
                 7 
                 2.86 
                 IR, Cancer 
                 X 
                 X 
               
               
                 Talin-1 
                 TLN1 
                 40 
                 2.15 
                   
                   
                 X 
               
               
                 Transthyretin 
                 TTR 
                 19 
                 0.70 
                   
                 X 
               
               
                   
               
               
                   a Ratio of the protein concentrations from HIV-infected patients with HL versus HIV-infected patients without HL. 
               
               
                   b An “X” indicates that IPA lists these tissues or cell types as a known source of these proteins. There are commonly other tissues or cellular sources for these proteins that are not included in this table. 
               
               
                   c WBC, white blood cells. 
               
               
                   d IR, inflammatory response.