Abstract:
This invention provides an improved process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride which is an intermediate for the preparation of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol which is useful for the treatment of osteoporosis.

Description:
BACKGROUND OF THE INVENTION 
       [0001]    This invention provides a process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride which is an intermediate In the synthesis of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol. 
         [0002]    A preparation of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthhalene-2-ol and salts thereof, also known as lasofoxifene, is described in U.S. Pat. No. 5,552,412. Lasofoxifene is the active ingredient in Oporia®, which is currently undergoing regulatory review. This compound is a selective estrogen receptor modulator and is useful for treatment and prevention of physiological disorders associated with menopause such as osteoporosis, vaginal atrophy, female sexual dysfunction, cardiovascular disease and breast cancer. U.S. Pat. No. 5,552,412 also describes the synthesis of cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine by hydrogenation of nafoxidine. The preparation of (−)cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol, D-tartrate is described in U.S. Pat. No. 5,948,809. 
       SUMMARY OF THE INVENTION 
       [0003]    This invention provides a process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride by the stereoselective hydrogenation of nafoxidine hydrochloride. This hydrogenation process maximizes the conversion of nafoxidine hydrochloride to cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride while minimizing the amount of the aromatized impurity 1-{2-[4-(6-methoxy-2-phenyl-naphthalen-1-yl)-phenoxy]-ethyl}-pyrrolidine hydrochloride produced. The depiction of the conversion of nafoxidine hydrochloride (compound I) to cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride (compound II) and the aromatized impurity (compound III) is shown in Reaction Scheme 1 below. 
         [0000]    
       
                 
         
             
             
         
       
     
     
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0004]    The present invention provides a hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride (hereinafter compound II) that maximizes the conversion of nafoxidine hydrochloride (hereinafter compound I) to the desired product while minimizing the amount of the aromatized impurity, 1-{2-[4-(6-methoxy-2-phenyl-naphthalen-1-yl)-phenoxy]-ethyl}-pyrrolidine hydrochloride (hereinafter compound III) produced. Compound I is 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalene-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride and is a compound known in the art and can be prepared by known methods, including methods described in U.S. Pat. No. 3,277,106. 
         [0005]    Numerous reaction condition parameters were explored to determine what reaction conditions favor the undesired formation of compound III when preparing compound II by hydrogenating compound I. Compound III is useful as an analytical standard for determining the purity of compound II. Table I, below, provides a listing of reaction parameters and specific reaction conditions that were investigated as well as the percentage of compound III and percentage of total impurities that were formed using those reaction conditions. All reaction parameters and conditions not specified remain substantially as in the standard hydrogenation reaction conditions as provided in Example 1, hereinbelow. 
         [0006]    The reaction parameters 1a-14b explored for the present hydrogenation process are provided in Table I below. The first three entries in Table I were carried out substantially according to the general procedure as described in Example 1. Parameters 1a-14b were explored by carrying out the procedure substantially according to the general procedure as described in Example 1, with the exception of a change in either or both of the parameter description and reaction condition as specified in columns 2 and 3 of the table. For example, parameter 1a was explored by carrying out the procedure of Example 1 with the exception that 9 mL of 2B ethanol per gram of compound I was used instead of the standard 13.5 mL/g as in Example 1. The reactions exploring parameters 1a-14b were typically carried out on a 15 g or 20 g scale based on the amount of the compound I starting material. The percentage of compound III and the percentage of total impurities were determined by HPLC according to a standard HPLC protocol. 
         [0007]    The standard HPLC analytical method employed a suitable liquid chromatograph equipped with a reverse phase 25 cm×4.6 mm Symmetry® C18 column (Waters Corporation, 34 Maple Street, Milford, Mass. 01757 USA), a UV detector capable of monitoring at 230 nm and an injector or auto-sampler capable of making 50 ∞L injections. Gradient elution was employed using a mixture of water, trifluoroacetic acid and ammonium hydroxide (adjusted to pH 3 with ammonium hydroxide) as mobile phase A and a mixture of water, acetonitrile, trifluoroacetic acid and ammonium hydroxide (adjusted to pH 3 with ammonium hydroxide) as mobile phase B. The retention time and relative retention time, R r , of compound III was approximately 22 minutes and approximately 0.96, respectively, when compared with compound II which had a retention time of 23 minutes and an R r  of approximately 1.00. 
         [0000]    
       
         
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE I 
               
               
                   
               
               
                   
                   
                   
                   
                 Com- 
                   
               
               
                   
                   
                   
                 Product 
                 pound 
                 Total 
               
               
                   
                 Parameter 
                   
                 Yield 
                 III 
                 Impurities 
               
               
                 Parameter 
                 Description 
                 Condition 
                 (%) 
                 (% w/w) 
                 (% w/w) 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Standard 
                 Standard 
                 Standard 
                 93.7 
                 1.9 
                 2.0 
               
               
                 Standard 
                 Standard 
                 Standard 
                 95.2 
                 2.4 
                 2.4 
               
               
                 Standard 
                 Standard 
                 Standard 
                 93.5 
                 2.4 
                 2.6 
               
               
                  1a 
                 2B Ethanol 
                 9 mL/g 
                 94.6 
                 1.9 
                 2.1 
               
               
                  1b 
                 2B Ethanol 
                 16 mL/g 
                 92.2 
                 2.3 
                 2.4 
               
               
                  2a 
                 Water 
                 1.0 mL/g 
                 95.1 
                 2.1 
                 2.2 
               
               
                  2b 
                 Water 
                 2.0 mL/g 
                 90.3 
                 1.4 
                 1.5 
               
               
                  3a 
                 2B ethanol 
                 9 mL/g 
                 94.9 
                 2.4 
                 2.7 
               
               
                   
                 Water 
                 2.0 mL/g 
               
               
                  3b 
                 2B ethanol 
                 16 mL/g 
                 93.0 
                 1.3 
                 1.4 
               
               
                   
                 Water 
                 2.0 mL/g 
               
               
                  4a 
                 Catalyst 
                 0.05 g/g 
                 96.4 
                 1.5 
                 1.6 
               
               
                   
                 charge 
               
               
                  4b 
                 Catalyst 
                 0.5 g/g 
                 92.2 
                 1.9 
                 2.6 
               
               
                   
                 charge 
               
               
                  5a 
                 Hydrogenation 
                 Ambient 
                 95.0 
                 8.8 
                 9.0 
               
               
                   
                 Pressure 
               
               
                  5b 
                 Hydrogenation 
                 10 psi 
                 95.2 
                 3.9 
                 4.0 
               
               
                   
                 Pressure 
               
               
                  5c 
                 Hydrogenation 
                 20 psi 
                 93.8 
                 2.2 
                 2.3 
               
               
                   
                 Pressure 
               
               
                  5d 
                 Hydrogenation 
                 60 psi 
                 94.3 
                 1.8 
                 1.9 
               
               
                   
                 Pressure 
               
               
                  6a 
                 Hydrogenation 
                 2 Hours 
                 91.5 
                 2.8 
                 2.9 
               
               
                   
                 Time 
               
               
                  6b 
                 Hydrogenation 
                 3 Hours 
                 94.1 
                 1.3 
                 1.4 
               
               
                   
                 Time 
               
               
                  6c 
                 Hydrogenation 
                 48 Hours 
                 93.2 
                 0.6 
                 1.4 
               
               
                   
                 Time 
               
               
                  6d 
                 Hydrogenation 
                 48 Hours 
                 95.6 
                 1.1 
                 2.1 
               
               
                   
                 Time 
               
               
                  7a 
                 Hydrogenation 
                 40° C. 
                 95.6 
                 1.7 
                 1.8 
               
               
                   
                 Temperature 
               
               
                  7b 
                 Hydrogenation 
                 60° C. 
                 92.7 
                 3.0 
                 3.5 
               
               
                   
                 Temperature 
               
               
                  8a 
                 Volume of 
                 1.0 mL/g 
                 93.0 
                 2.9 
                 3.0 
               
               
                   
                 Ethanol 
               
               
                   
                 Concentrate 
               
               
                  8b 
                 Volume of 
                 5.0 mL/g 
                 94.5 
                 2.7 
                 2.8 
               
               
                   
                 Ethanol 
               
               
                   
                 Concentrate 
               
               
                  9a 
                 Volume 
                 10.0 mL/g 
                 97.2 
                 2.4 
                 2.6 
               
               
                   
                 Added 
               
               
                   
                 Toluene 
               
               
                  9b 
                 Volume 
                 30 mL/g 
                 92.5 
                 2.6 
                 2.8 
               
               
                   
                 Added 
               
               
                   
                 Toluene 
               
               
                 10a 
                 Volume of 
                 2 mL/g 
                 93.1 
                 2.8 
                 3.1 
               
               
                   
                 Toluene 
               
               
                   
                 Concentrate 
               
               
                 10b 
                 Volume of 
                 5 mL/g 
                 93.0 
                 1.8 
                 1.8 
               
               
                   
                 Toluene 
               
               
                   
                 Concentrate 
               
               
                 10c 
                 Volume of 
                 8 mL/g 
                 94.6 
                 1.6 
                 1.7 
               
               
                   
                 Toluene 
               
               
                   
                 Concentrate 
               
               
                 11 
                 Granulation 
                 72 Hours 
                 96.5 
                 3.4 
                 3.6 
               
               
                   
                 Time 
               
               
                 12a 
                 Granulation 
                 0° C. to 
                 95.9 
                 2.8 
                 3.0 
               
               
                   
                 Temperature 
                 5° C. 
               
               
                 12b 
                 Granulation 
                 30° C. 
                 94.3 
                 2.5 
                 2.6 
               
               
                   
                 Temperature 
               
               
                 13 
                 Drying 
                 45° C. 
                 93.4 
                 3.3 
                 3.4 
               
               
                   
                 Temperature 
               
               
                   
                 (no vacuum) 
               
               
                 14a 
                 Drying Time at 
                 5 Hours 
                 89.0 
                 0.5 
                 0.5 
               
               
                   
                 60° C. 
               
               
                 14b 
                 Drying Time at 
                 48 Hours 
                 88.3 
                 0.5 
                 0.5 
               
               
                   
                 60° C. 
               
               
                   
               
             
          
         
       
     
         [0008]    When exploring the reaction parameters 1a-14b, it was found that the percentage of compound III being formed correlated with parameters involving the reaction temperature and the hydrogenation pressure. Particularly, the amount of compound III formed increased with decreased hydrogenation pressure and higher reaction temperature as seen for parameters 5a-5d and 7a-7b in Table I. 
         [0009]    Further investigation determined compound III is formed when the reaction mixture is at lower hydrogenation pressure and elevated temperatures, as shown below in Table II. 
         [0000]    
       
         
               
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                   
                 TABLE II 
               
             
             
               
                   
                   
               
               
                   
                 Hydrogenation Reaction Pressure 
               
               
                   
                 (atm hydrogen) at 45-55° C. 
               
             
          
           
               
                   
                 0 
                 0.681 
                 1.36 
                 3.07 
               
               
                   
                 atmospheres 
                 atmospheres 
                 atmospheres 
                 atmospheres 
               
               
                   
                   
               
             
          
           
               
                 Amount of 
                 18-24% 
                 8% 
                 2-3% 
                 &lt;2% 
               
               
                 Compound III 
               
               
                 in Reaction 
               
               
                   
               
             
          
         
       
     
         [0010]    As shown in Table II, when the reaction mixture is heated at 45° C. to 55° C. at 0 atmospheres hydrogen pressure compound III is present between 18% to 24% of the total reaction yield. When the hydrogenation reaction is first pressurized to 0.681 atmospheres and then heated to 45° C. to 55° C. the amount of compound III decreased to about 8% of the total reaction yield. The trend of decreasing amounts of compound III with increasing hydrogenation pressure prior to heating the reaction mixture continued as higher pressures were applied before heating the reaction mixture. When the hydrogenation reaction is first pressurized to 1.36 atmospheres or 3.07 atmospheres and then heated to 45° C. to 55° C. the amount of compound III decreased to about 2% to 3% and less than 2%, respectively, of the total reaction yield. 
         [0011]    In a typical hydrogenation reaction that requires both heat and pressure, the reaction vessel is charged with an appropriate catalyst, starting material and solvent system and the system is heated prior to pressurizing it with hydrogen. Heating the reaction mixture prior to pressurizing it with hydrogen is standard practice because this allows for easier equilibration and monitoring of the reaction pressure. Compound I can not routinely be converted to compound II with less than about 2.5% of compound III present by way of the standard hydrogenation sequence of heating the hydrogenation reaction mixture prior to pressurizing with hydrogen. Instead, to obtain compound II with less than about 2.5% of compound III present the reaction mixture must be pressurized with hydrogen prior to the application of heat and the pressure has to be continually adjusted as increasing temperature elevates the pressure of the closed system. This sequence of carrying out the hydrogenation effectively minimizes the formation of compound III. 
         [0012]    For the purposes of this hydrogenation, it was found that optimal hydrogen pressures for the minimization of compound III are in the range of about 1.36 atmospheres to about 6.80 atmospheres (about 20 psi to about 100 psi), preferably in the range of about 3.07 atmospheres to about 3.75 atmospheres (about 45 psi to about 55 psi). After pressurizing the reaction mixture under hydrogen, the hydrogenation reaction mixture is heated to a temperature greater than 20° C., preferably in the range of about 20° C. to 60° C. Heating the hydrogenation reaction mixture using the described sequence ensures that the hydrogenation converts about 98% of compound I to the desired compound II. The optimal temperature for carrying out the hydrogenation is in the range of about 44° C. to 55° C. 
         [0013]    Any suitable solvent or solvent system can be used for the purposes of this hydrogenation. Although not required, a polar, protic solvent or solvent system is preferred for reasons of solubility. Appropriate solvents that can be used alone or as part of a solvent system for this hydrogenation include, but are not limited to, methanol, ethanol, propanol, isopropanol, tetrahydrofuran and water. A particular solvent system useful for this hydrogenation is a mixture of ethanol and water, more particularly a 9:1 mixture of ethanol and water. The concentration of the reaction mixture was not found to be critical, but this hydrogenation is typically run at a concentration of about 0.17 M with respect to the starting material compound I. 
         [0014]    Any suitable hydrogenation catalyst can be used for the purposes of this hydrogenation. Examples of hydrogenation catalysts that can be used include palladium on carbon, palladium hydroxide, palladium on alumina, palladium on calcium carbonate, nickel catalysts, rhodium on carbon, platinum on carbon, chlorotris(triphenylphosphine)rhodium(I), and dichlorotris(triphenylphosphine) ruthenium(II). A preferred catalyst for this hydrogenation is palladium on carbon and more particularly 5% palladium on activated carbon. 
         [0015]    The present hydrogenation process can be carried out for several hours to several days, however the optimal yield of compound II is attained in about 4 to 8 hours. When analysis of the hydrogenation reaction mixture by LCMS shows less than 1% of compound I starting material remaining the reaction is considered complete. The reaction mixture is then cooled, vented to remove the hydrogen and purged with nitrogen. The reaction mixture is then filtered through a filter aid such as a diatomaceous earth (Celite 545®, Mallinckrodt Baker, Inc., Phillipsburg, N.J. 08865, USA) to remove the catalyst. The hydrogenation reaction vessel and filter cake are then washed with an appropriate solvent such as 2B ethanol and the combined filtrate is concentrated under vacuum at about 30° C. to 50° C. The concentrate is then azeotroped with toluene and concentrated under vacuum at about 30° C. to 50° C. again to a concentration of about 2.7 mL/g based on the amount of compound I originally used. The resulting slurry is cooled to about 20° C. and stirred for about 2 hours. The product is then collected by filtration and washed with toluene then dried under vacuum at about 40° C. to 50° C. until a constant weight is achieved. The resulting compound II is typically in a mean yield of about 97.5% with 2.2±0.3% of total impurities. 
         [0016]    The present invention provides a specific hydrogenation process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride, wherein said cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride contains less than about 5% of 1-{2-[4-(6-methoxy-2-phenyl-naphthalen-1-yl)-phenoxy]-ethyl}-pyrrolidine hydrochloride, the process comprising, in the following order, the steps of:
       (a) charging a hydrogenation reaction vessel with an appropriate hydrogenation catalyst and a solution of 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalene-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride in an appropriate solvent;   (b) pressurizing the hydrogenation reaction vessel with hydrogen to a pressure of at least 20 psi to provide a hydrogenation reaction mixture;   (c) heating the hydrogenation reaction mixture of step 2 at a temperature of at least 20° C. until 1% or less of the 1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalene-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride remains to provide cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride;   (d) isolating the resulting cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride; wherein the resulting cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride contains less than about 2.5% of 1-{2-[4-(6-methoxy-2-phenyl-naphthalen-1-yl)-phenoxy]-ethyl}-pyrrolidine hydrochloride.       
 
         [0021]    In the present invention the pressure range in step (b) of the hydrogenation process is 20 psi to about 100 psi, with a preferred pressure in step (b) being 20 psi to about 60 psi, and a more preferred pressure range in step (b) being about 45 psi to about 55 psi. The temperature range in step (c) of the hydrogenation process is at least 20° C. to about 60° C. with a preferred temperature range in step (c) being about 45° C. to about 55° C. A preferred process of this invention is one wherein the pressure in step (b) is about 45 psi to about 55 psi and the temperature in step (c) is about 45° C. to about 55° C. In a further embodiment of this invention the hydrogenation catalyst in step (a) of the process is palladium on carbon and the solvent in step (a) is a mixture of ethanol and water. A preferred embodiment of the invention is one wherein the hydrogenation catalyst is 5% palladium on activated carbon. Another preferred embodiment of the invention is one wherein the solvent in step (a) is a 9:1 mixture of ethanol to water. Yet another preferred embodiment of the invention is the process wherein the hydrogenation catalyst in step (a) is 5% palladium on activated carbon and the solvent in step (a) is a 9:1 mixture of ethanol to water, the pressure in step (b) is about 45 psi to about 55 psi and the temperature in step (c) is about 45° C. to about 55° C. 
         [0000]    Abbreviations used in this description are defined as follows: 
         [0022]    g gram(s) 
         [0023]    kg kilogram(s) 
         [0024]    mL milliliter(s) 
         [0025]    L liter(s) 
         [0026]    LCMS liquid chromatography mass spectrometry 
         [0027]    ° C. degrees Celsius 
         [0028]    psi pounds per square inch 
         [0029]    UV ultraviolet 
       Examples 
       [0030]    Examples 1 provides a general procedure for the conversion of compound I to compound II containing less than about 2.5% of compound III. Examples 2 and 3 provide further examples of this process. 
       Example 1 
       [0031]    General Procedure: Charge nafoxidine hydrochloride (anhydrous, solvent free weight, 1.0 molar equivalent) to the hydrogenation reaction vessel followed by 2B ethanol (13.5 mL/g of nafoxidine hydrochloride) and water (1.5 mL/g of nafoxidine hydrochloride). Saturate the reaction mixture with nitrogen and add an appropriate hydrogenation catalyst (0.2 g catalyst/g of nafoxidine hydrochloride). Record the weight of the reaction mixture and pressurize the reaction mixture under a hydrogen atmosphere at a pressure of about 3.40 to about 3.74 atmospheres. Heat the reaction mixture until the temperature is in the range of about 48° C. to about 53° C. The pressure increases as the reaction mixture temperature increases and the pressure is adjusted as required to maintain the pressure in the range of about 3.40 to about 3.74 atmospheres. The reaction is monitored after an initial four-hour hydrogenation period and the hydrogenation is allowed to proceed for up to seventy-two hours, typically for four to eight hours, until the reaction is complete with ≦1% of the nafoxidine hydrochloride starting material remaining. The reaction mixture is sampled by cooling the reaction mixture to 20° C. to 35° C., carefully venting the hydrogen and sampling the reaction mixture. After completion of the reaction, the reaction mixture is filtered through Celite 545® to remove the catalyst and the reaction vessel and filter cake are washed with two charges of 2B ethanol (2×2 mL/g of nafoxidene hydrochloride starting material). The combined filtrate is concentrated in vacuo at 30° C. to 50° C. until the concentration is approximately 2.6 mL/g of nafoxidine hydrochloride starting material. Charge toluene (total volume: 20 mL/g of nafoxidine hydrochloride starting material divided in 3 lots) to the concentrated filtrate and concentrate in vacuo each time until the concentration is approximately 2.7 mL/g of nafoxidine hydrochloride starting material. Cool the resulting slurry to 20° C. to 25° C. and agitate for about 2 hours at this temperature. Collect the product by filtration and wash the filter cake with two lots of toluene (total volume: 4.75 mL/g of the nafoxidine hydrochloride starting material). Dry the cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride product at 40° C. to 50° C. to a constant weight. 
         [0032]    The first three entries in Table 1 were carried out according to the above procedure and resulted in the preparation of compound II in 93.7, 95.2 and 93.5 percent yield containing 1.9, 2.4 and 2.4 percent of compound III with total impurities of 2.0, 2.4 and 2.6 percent, respectively. 
       Example 2 
       [0033]    To a hydrogenation reaction vessel under a nitrogen atmosphere was charged 6.4 kg of 5% palladium on carbon catalyst. In a separate vessel, 32 kg of nafoxidine hydrochloride, 336 L of 2B ethanol and 33.6 L of process water were combined and this mixture was agitated at 15° C. to 25° C. for at least 30 minutes. The resulting solution was transferred into the hydrogenation reaction vessel. The separate vessel was rinsed with 96 L of 2B ethanol and 14.4 L of process water and this rinse was transferred to the hydrogenation reaction vessel. The hydrogenation reaction vessel was then pressurized to 3.07 atmospheres with hydrogen gas and then heated to 48° C. to 53° C. The pressure in the hydrogenation vessel was then increased to 3.4 to 3.7 atmospheres. After hydrogen uptake ceased the hydrogenation reaction was allowed to continue for an additional four hours, then was cooled to 20° C. to 30° C. and the catalyst was filtered off through a Celite® precoated sparkler. The sparkler was washed twice with 64 L of 2B ethanol. The combined filtrate was concentrated in vacuo to a volume of 86 L 160 L of toluene was added to the filtrate and this mixture was then concentrated in vacuo to a volume of 86 L. 320 L of toluene was then added to the filtrate and the resulting mixture was again concentrated in vacuo to a volume of 86 L. 160 L of toluene was again added to the filtrate and the filtrate was again concentrated in vacuo to a volume of 86 L. The resulting slurry was cooled to 20° C. to 25° C. and granulated for a minimum of two hours with low to medium agitation. The product was then collected by filtration and the filter cake was washed twice with toluene (80 L and 72 L, respectively). The filter cake was then partially dried under nitrogen at ambient temperature to about 80-90% of its original weight. 
       Example 3 
       [0034]    A hydrogenation reaction vessel was charged with 3.0 g of 5% palladium on carbon catalyst. In a separate vessel, 15.00 g of nafoxidine hydrochloride was combined with 157 mL of 2B ethanol and 15.75 mL of process water and was agitated at 15° C. to 25° C. for a minimum of 30 minutes and the resulting solution was transferred into the hydrogenation reaction vessel. The separate vessel was rinsed with 45 mL 2B ethanol and 6.75 mL process water and this rinse was transferred to the hydrogenation reaction vessel. The hydrogenation reaction vessel was then pressurized to 3.07 atmospheres with hydrogen gas and then heated to 48° C. to 53° C. The pressure in the hydrogenation vessel was then increased to 3.4 to 3.7 atmospheres. After hydrogen uptake ceased the hydrogenation reaction was allowed to continue for an additional four hours, then was cooled to 20° C. to 30° C. and the catalyst was filtered off through a Celite® precoated sparkler. The sparkler was washed twice with 30 mL of 2B ethanol. The combined filtrate was concentrated in vacuo to a volume of 40 mL. 75 mL of toluene was added to the filtrate and this mixture was then concentrated in vacuo to a volume of 40 mL. 150 mL of toluene was then added to the filtrate and the resulting mixture was again concentrated in vacuo to a volume of 40 mL at which point cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride precipitated from solution. 75 mL of toluene was again added to the filtrate and the filtrate was again concentrated in vacuo to a volume of 40 mL. The resulting slurry was cooled to 20° C. to 25° C. and granulated for a minimum of two hours with low to medium agitation. The product was then collected by filtration and the filter cake was washed twice with toluene (38 mL and 34 mL, respectively). The filter cake was then dried at 45° C. to 50° C. for 12 hours to obtain 8.00 g of cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride as a white solid.