Abstract:
Disclosed is a catheter used to pick a sample of a lesion cell tissue existing in the living body, and more particularly a catheter capable of freely coupling or separating a micro biopsy tool and picking a tissue required for an examination just by inserting and extracting the biopsy tool into and from a lesion region when picking the tissue. The catheter can pick a tissue required to diagnose and treat an examinee with a minimal invasion. Accordingly, it is possible to alleviate the examinee&#39;s pain and to prevent a perforation from occurring in the picked region when picking the tissue. In addition, according to the catheter of the invention, since the micro biopsy tool can be easily mounted and separated, the catheter can be semi-permanently used by continuously replacing the biopsy tool only.

Description:
CROSS-REFERENCE TO RELATED APPLICATION  
       [0001]     The present application is claiming priority of Korean Patent Application No. 10-2005-0011477, filed on Feb. 7, 2005, the content of which is herein incorporated by reference.  
       BACKGROUND OF THE INVENTION  
       [0002]     1. Field of the Invention  
         [0003]     The present invention relates to a catheter used to pick a sample of a lesion cell tissue existing in a living body, and more particularly to a catheter capable of freely coupling or separating a micro biopsy tool and picking a tissue required for an examination just by inserting and extracting the biopsy tool into and from a lesion region when picking the tissue.  
         [0004]     2. Background of the Related Art  
         [0005]     A micro biopsy tool is a term referring to a needle or spike type micro tool capable of picking a micro tissue so as to examine and treat a lesion cell tissue existing in a living body. As an example of the micro biopsy tool, there is a barb-wired micro needle made of single crystal silicon. The micro biopsy tool can be manufactured through a micro-electro-mechanical system (MEMS) process, a LIGA (Lithographic, Galvanoformung, Abformung) process, a precision metal processing and a mold.  
         [0006]     As a use example of the micro biopsy tool, a pathological examination picking a tissue sample from a patient so as to diagnose the patient&#39;s disease is a very important process to diagnose the disease and to determine a treatment method. The micro biopsy tools may be used with being mounted in a catheter which is a kind of conduit which is inserted into a human organ such as a blood vessel or an urethra.  
         [0007]     However, since a diagnosis method using a catheter according to the prior art picks an examinee&#39;s cell tissue in great quantity beyond necessity due to its structural cause, thereby causing a pain and a risk to the examinee. In addition, as a typical picking method, there is a method of picking the tissue with forceps. However, according to this method, a great pain is caused to the examinee. Further, when an operator, who lacks an experience in the tissue picking, performs the medical treatment, a digestive organ such as the stomach is perforated, so that an emergency may occur.  
         [0008]     For solving the above problems, there are suggested catheter tools made by applying a precise micro machining process. As an example, there is suggested a catheter having improved a shape of the forceps so as to increase an accuracy of the tissue picking and a picking amount.  FIG. 1  shows a catheter used to pick a tissue sample according to the prior art. As shown, the catheter comprises forceps jaws  202 , a micro needle  204  and a main body  201 .  
         [0009]     The catheter  200  shown in  FIG. 1  has a structure such that the micro needle  204  having a concavo-convex structure is mounted to a center of the catheter and the forceps jaws  202  are mounted to both sides of the needle. The catheter  200  of  FIG. 1  picks a tissue such a manner that a surface of the tissue is stretched when pricking and drawing the tissue  300  with the micro needle  204  and then the forceps jaws  202  pick up and separate the stretched tissue. The catheter  200  of  FIG. 1  has an advantage of securing an accurate picking amount when picking the tissue.  
         [0010]     However, when picking the tissue with the catheter  200  of  FIG. 1 , since two processes of pricking the tissue with the micro needle  204  and picking and separating the tissue with the forceps jaws  202  should be performed, an examinee&#39;s pain is increased. In addition, there is an inconvenience that a movement of forceps jaws  202  should be manipulated to separate the tissue under state that the tissue is stretched with the micro needle  204 .  
         [0011]     Additionally, since a catheter such that shown in  FIG. 1  is manufactured to be integral with the forceps, it should be discarded after being used once for the tissue picking. In other words, the prior catheter can be used only for a disposable.  
         [0012]     Accordingly, there is a need of a catheter capable of alleviating an examinee&#39;s pain and being easily manipulated and repeatedly used.  
       SUMMARY OF THE INVENTION  
       [0013]     Accordingly, the present invention has been made to solve the above-mentioned problems occurring in the prior art. The object of the present invention is to provide a catheter equipped with a micro biopsy tool capable of picking a tissue with one invasion, thereby minimizing an examinee&#39;s pain due to the tissue picking.  
         [0014]     Another object of the invention is to easily mount and separate a micro biopsy tool and thus to provide a catheter capable of being reused for another medical treatment by replacing only the micro biopsy tool after a medical treatment.  
         [0015]     Still another object of the invention is to provide a catheter with which even an operator who lacks an experience in the tissue picking can easily pick the tissue just by picking the tissue with one invasion.  
         [0016]     In order to accomplish the objects, there is provided a catheter comprising a fixing body capable of mounting a micro biopsy tool; and an external cover having the fixing body therein. The fixing body can be reciprocally moved in the external cover by a regulating wire passing through the external cover from an exterior. The external cover is formed with a front opening at a front surface thereof so that the micro biopsy tool can be reciprocally moved though the front opening, and a rear opening penetrated by the regulating wire at a rear surface.  
         [0017]     As methods for mounting the micro biopsy tool to the fixing body, a method using a curve feature of a spring plate, a fixing method by two semicircular columns combined each other by a pin and formed with a recess respectively, a fixing method by a circular column formed with a recess and using adhesives or ultrasonic welding, and the like.  
         [0018]     Additionally, the external cover may be constructed as a separate type which comprise an upper cover formed with a front opening at a front surface thereof so that the micro biopsy tool can be reciprocally moved when picking a tissue; and a lower cover detachably coupled to the upper cover and formed with a rear opening penetrated by the regulating wire at a rear surface. Or the external cover may be constructed as one body type which has specific shape of recess so as to restrict the fixing body not to rotate in the external cover and to regulate the length of the movement of the fixing body in the front and the rear.  
         [0019]     In addition, the catheter according to the invention may be characterized in that the fixing body does not move laterally on the path of a tissue picking. 
     
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       [0020]     The above and other objects, features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which:  
         [0021]      FIG. 1  shows a catheter used to pick a tissue sample according to the prior art;  
         [0022]      FIG. 2A  shows a device for picking tissue including a catheter according to an embodiment of the invention;  
         [0023]      FIG. 2B  shows an external structure of a catheter according to an embodiment of the invention;  
         [0024]      FIG. 3  is an exploded view of a catheter according to an embodiment of the invention;  
         [0025]      FIG. 4  is an exploded view of the catheter, viewing from a point other than in  FIG. 3 ;  
         [0026]      FIG. 5  illustrates an example of a biopsy tool equipped to a catheter according to an embodiment of the invention;  
         [0027]      FIG. 6  shows a fixing body constituting a catheter according to an embodiment of the invention;  
         [0028]      FIG. 7A  shows a fixing plate constituting a catheter according to an embodiment of the invention;  
         [0029]      FIG. 7B  shows that the fixing plate shown in  FIG. 7A  is bended.  
         [0030]      FIG. 8A  shows a shape that each constituent of a catheter according to an embodiment of the invention is disassembled;  
         [0031]      FIG. 8B  shows that each constituent of the catheter shown in  FIG. 8A  is assembled;  
         [0032]      FIG. 9A  shows that a catheter according to an embodiment of the invention is inserted to tissues in order to pick a tissue sample.  
         [0033]      FIG. 9B  shows that the catheter of  FIG. 9A  is drawn from the tissues.  
         [0034]      FIG. 10A  shows a catheter according to another embodiment of the invention.  
         [0035]      FIG. 10B  shows the catheter of  FIG. 10A  mounting a micro biopsy tool.  
         [0036]      FIG. 10C  shows that a fixing body mounting the micro biopsy tool moves along a recess of an external cover in  FIG. 10A .  
         [0037]      FIG. 10D  shows that the fixing body mounting the micro biopsy tool has moved to a standby state for picking a tissue in  FIG. 10A .  
         [0038]      FIG. 10E  shows that the fixing body mounting the micro biopsy tool has moved to a state for picking a tissue in  FIG. 10A .  
         [0039]      FIG. 10F  shows that the fixing body has moved to a state that the micro biopsy tool can be separated from it in  FIG. 10A .  
         [0040]      FIG. 11A  shows an external cover according to another embodiment of the invention.  
         [0041]      FIG. 11B  shows a state that an upper cover and a lower cover constituting the external cover of  FIG. 11A  respectively are combined to each other.  
         [0042]      FIG. 12A  shows a fixing body according to another embodiment of the invention.  
         [0043]      FIG. 12B  shows that a micro biopsy tool is mounted to the fixing body of  FIG. 12A .  
         [0044]      FIG. 13A  shows a fixing body constituted by two semicircular columns according to another embodiment of the invention.  
         [0045]      FIG. 13B  shows that two semicircular columns shown in  FIG. 13A  are combined to each other.  
         [0046]      FIG. 14A  shows a fixing body according to another embodiment of the invention.  
         [0047]      FIG. 14B  shows that a micro biopsy tool is mounted to the fixing body of  FIG. 14A .  
         [0048]      FIG. 15A  shows a fixing body according to another embodiment of the invention.  
         [0049]      FIG. 15B  shows that the fixing body of  FIG. 15A  is combined to a regulating wire.  
         [0050]      FIG. 15C  shows that the fixing body of  FIG. 15B  is combining to a micro biopsy tool with a bolt.  
         [0051]      FIG. 15D  shows that the fixing body of  FIG. 15B  has combined to a micro biopsy tool. 
     
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS  
       [0052]     Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.  
         [0053]      FIGS. 2A and 2B  show an external structure of a catheter  100  according to an embodiment of the invention and a device for picking tissue including the catheter  100 . The catheter  100  shown in  FIGS. 2A and 2B  is equipped with a biopsy tool  110  and a body part of the catheter is mounted in external covers  120 ,  130 . A regulating wire  20 , which is capable of regulating a reciprocating motion of the biopsy tool  110  when picking a tissue, is extended to a regulating part  190  through the external cover. The regulating part  190  is structured to regulate the reciprocating motion of the regulating wire  20  automatically or manually.  
         [0054]      FIG. 3  is an exploded view of the catheter shown in  FIGS. 2A and 2B . As shown, the body part of the catheter comprises a fixing body  10 , the regulating wire  20  and a fixing plate  30 . The external cover comprises an upper cover  120  and a lower cover  130 .  
         [0055]     The fixing body  10  is formed with a recess for inserting the biopsy tool  110  and directly coupled to the regulating wire  20 . In the embodiment shown in  FIG. 3 , a fixing pin  52  is used to couple the fixing body  10  and the regulating wire  20 . Like this, since the fixing body  10  is fixedly coupled to the regulating wire  20 , the fixing body  10  is reciprocally moved when the Regulating wire  20  is reciprocally moved for picking a tissue.  
         [0056]     Preferably, a wire guide  40  for restricting a lateral movement of the regulating wire  20  may be fixedly coupled to the fixing body  10  and the regulating wire  20 . In this case, the fixing body  10 , the regulating wire  20  and the wire guide  40  may be fixed with one fixing pin  52 . The wire guide  40  can prevent the regulating wire  20  from being bended or collided with an inner wall of the external cover  120 ,  130  by restricting the lateral movement of the regulating wire  20 , thereby causing the regulating wire  20  to reciprocally move smoothly in the external cover  120 ,  130 .  
         [0057]     The fixing plate  30  is provided to prevent the micro biopsy tool  110  from being separated from the fixing body  10  when the micro biopsy tool  110  is inserted into the fixing body  10 . The fixing plate  30  is coupled to the fixing body  10  while covering a part of a surface of the micro biopsy tool  110 . A detailed description of the fixing plate will be mentioned later.  
         [0058]     A front surface of the upper cover  120  is formed with an opening so that the micro biopsy tool  110  can be reciprocally moved. That is, the micro biopsy tool  110  is mounted in the external cover and then protruded outwardly from the external cover by a regulation of the regulating wire  20  and then inserted into a tissue when picking the tissue. Like this, the front surface of the upper cover  120  is formed with the opening so that the micro biopsy tool  110  can be reciprocally moved in and out of the external cover.  
         [0059]     The lower cover  130  is combined with the upper cover  120  to constitute the external cover. The upper and lower covers  120 ,  130  are formed with an annulus recess  122  and an annulus protrusion  132  having a concavo-convex shape at each of coupling portions thereof to easily separate or couple them, as shown in  FIG. 3 . The other side of the lower cover  130  is penetrated by the regulating wire  20 .  
         [0060]     Preferably, a protective pipe  170  for protecting an outwardly extended part of the regulating wire  20  and allowing a general reciprocating motion of the regulating wire  20  to be smoothly achieved may be bonded to the lower cover  130 . The protective pipe  170  may be structured to extend from the lower cover  130  to the regulating part, thereby shielding and protecting the regulating wire  20 . Preferably, the bonding of the lower cover  130  and the protective pipe  170  may be achieved with laser welding.  
         [0061]     A size of the catheter is preferably limited within a predetermined range, considering a characteristic of the tool being inserted into a living body. From this point of view, in  FIG. 2B , it is preferred that a length L of the external cover is within a range of 5 mm˜15 mm, and a width W of the external cover is within a range of 1.0 mm˜10 mm.  
         [0062]     In addition, it can be structured that the external cover is formed into a cylindrical shape and has a round-shaped edge so as to smoothly move in the living body.  
         [0063]     Hereinafter, each of elements constituting the body part will be more specifically described.  FIG. 5  shows an example of the biopsy tool  110  equipped to the catheter of the invention. As shown, the biopsy tool  110  equipped to the catheter of the invention may comprise a body insertion part  112 , an extension part  114  and a protrusion part  116 . The body insertion part  112  is a part which is inserted into the recess formed in the fixing body  10  so as to couple to the fixing body  10 . The extension part  114  is a part which is inserted into a tissue cell according to a regulation of the regulating part  190  when picking a tissue. The protrusion part  116  is a part which is protruded from a side surface of the extension part  112  and allows a tissue sample to be caught by the protrusion part and taken off together with it when the extension part is inserted and then extracted into and from the tissue cell.  
         [0064]     Like this, since the biopsy tool  110  used in the embodiment of the invention can pick a tissue sample just by inserting and extracting the biopsy tool into and from a lesion region. A biopsy tool combined to a catheter according to the invention may be manufactured with three-dimensional structure having single crystal silicon as its raw material, or with two-dimensional structure through a precision metal processing and LIGA (Lithographic, Galvanoformung, Abformung) process.  
         [0065]      FIG. 6  shows the fixing body  10  constituting the body part of the catheter of the invention. As shown, the fixing body  10  is formed with recesses  2  for inserting and fixing the biopsy tool  110  and a space  4  for coupling to the wire guide  40  and the regulating wire  20 . In addition, it is formed with an aperture  6  for inserting the fixing pin  52  when the fixing body is coupled with wire guide  40  and the regulating wire  20  using the fixing pin  52 . Like this, the fixing body  10  is fixedly coupled with the regulating wire  20  and thus reciprocally moves together with the regulating wire  20  in the external cover  120 ,  130  when picking the tissue.  
         [0066]     Although the fixing body is formed with the two recesses  2  for inserting the biopsy tool  110 , one or more recesses may be formed as necessary. After inserting the biopsy tool  110  into the recesses, the fixing plate  30  is coupled with the fixing body  10  so as to prevent the tool from being arbitrarily separated. The fixing body  10  is formed with a recess  8  for coupling to the fixing plate  30  at an inner circumference of an inlet thereof.  
         [0067]      FIGS. 7A and 7B  show the fixing plate  30  coupling to the fixing body  10  so as to prevent a separation of the biopsy tool  110 . As shown in  FIG. 7B , the fixing plate  30  is made of an elastic material enough to bend and fit it into the fixing recess  8  of the fixing body from an exterior. In other words, in order to fit the fixing plate  30  into the recess  8  of the fixing body  10 , a force is applied to the fixing plate  30  to bend under state that the fixing plate  30  is picked up with a hand or pincettes. Then, under the bended state, the fixing plate is inserted into an inlet of the fixing body  10  and fitted into the recess  8  formed in the inner surface thereof. Like this, when the fixing plate  30  is coupled with the fixing body  10 , each side parts  32 ,  34  of the fixing plate cover a part of a surface of the biopsy tool  110  inserted into the fixing body, so that it is possible to prevent the biopsy tool  110  from being arbitrarily separated.  
         [0068]      FIGS. 8A and 8B  show a coupled state of the fixing body  10 , the regulating wire  20  and the wire guide  40  of the catheter of the invention. As shown, each of the fixing body  10 , the regulating wire  20  and the wire guide  40  is formed with an aperture for passing the fixing pin  52 , so that they can be fixedly coupled using one fixing pin  52 . The fixing body  10 , the regulating wire  20  and the wire guide  40  coupled like this reciprocally moves together in the external cover when picking the tissue. After inserting the fixing pin  52 , a pad  54  can be coupled with a lower end of the fixing pin  52  outwardly protruding from the aperture, so as to prevent the fixing pin from being separated.  
         [0069]      FIGS. 9A and 9B  show a process of picking the tissue sample with the catheter of the invention. As shown in  FIG. 9A , the extension part  114  (referring to  FIG. 5 ) of the biopsy tool  110  is inserted into the tissue  500  so as to pick the tissue sample. Under state that the extension part of the biopsy tool  110  is inserted, the regulating wire  20  is manipulated through a regulating part  190  (referring to  FIG. 2A ) in the exterior of the living body, thereby causing the biopsy tool  110  inserted into the tissue  500  to be extracted and to get into the external cover  120 ,  130 .  FIG. 9B  shows a state that the extension part  114  of the biopsy tool has gotten into the external cover. That is, the extension part  114  of the biopsy tool  110  is extracted from the tissue  500  and allowed to get into the external cover  120 ,  130  by rearward moving the body part of the catheter combining with the regulating wire  20  of the regulating part  190 . In this case, during the extraction of the biopsy tool  110 , the tissue sample is caught between the extension part  114  of the biopsy tool  110  and taken off together with it, and the tissue sample taken off gets into the external cover  120 ,  130  together with the extension part  114 . Like this, since the tissue sample moves to the exterior of the living body under state that it is embedded in the external cover, it is possible to safely move the tissue sample without losing it.  
         [0070]     A catheter according to another embodiment of the invention is shown in  FIG. 10A . For the catheter  300  of  FIG. 10A , a fixing body  324  having a convex and circular protrusion  325  moves in an external cover  330  having a cylinder shape formed with a recess  331  of specific path. Like this, it is possible to guide the movement of the fixing body  324  and restrict the lateral movement and round movement, which is not intended, of the fixing body  324  in the external cover  330 . In addition, the movement length in the front-rear direction may be regulated in accordance with the length of the recess  331 .  
         [0071]     Meanwhile, as shown in  FIG. 10A , the fixing body  324  may be manufactured such that a corresponding portion combining with a micro biopsy tool  310  is divided into a cover part  321  and a base part  322 , wherein the cover part  321  and the base part  322  may be combined by a pin  323  so that a separation and a combination of the micro biopsy tool  310  can be performed easily. A specific description for the fixing body  324  will be described later.  
         [0072]     As described in the above, the operation of the catheter  300  can be controlled by the regulating wire  340 .  FIGS. 10B, 10C ,  10 D and  10 E show the operation process of the catheter  300 .  FIG. 10B  shows the catheter mounting a micro biopsy tool. In  FIG. 10B , the protrusion  325  formed on the fixing body  324  is in a state to moving to the front end of the path of the recess  331 . As shown in  FIGS. 10A and 10B , for the fixing body  324 , the micro biopsy tool  310  can be simply mounted by putting the micro biopsy tool  310  in the portion of which cover part  321  is in open state, and then closing the cover part  321 .  FIG. 10C  shows that the fixing body  324  mounting the micro biopsy tool  310  moves in the rear direction along the recess  331  of the cover  330 . As shown in  FIG. 10C , the fixing body  324  moved along the ‘A’ path of the path formed to the external cover  330 , and then moves along the ‘B’ path.  
         [0073]      FIG. 10D  shows that the fixing body  324  mounting the micro biopsy tool  310  is in a standby state for picking a tissue by moving to the rear end of the path of the recess  331 . The fixing body  324  may be in the standby state by moving in the rear direction along the ‘C’ path after moving along the ‘A’ path and the ‘B’ path of the recess  331  sequentially as shown in  FIG. 10C . The catheter  300  may be constructed such that the micro biopsy tool  310  does not protrude outside of the external cover  330  in the standby state for picking a tissue.  
         [0074]      FIG. 10E  shows that the fixing body  324  mounting the micro biopsy tool  310  has moved in a state for picking a tissue. As shown in  FIG. 10E , the catheter  300  may be constructed such that the fixing body  324  does not protrude outside of the external cover  330 , only while the micro biopsy tool  310  protrudes outside of the external cover  330  in the state for picking a tissue. Like this, in the state that the micro biopsy tool  310  protrudes outside of the external cover  330 , the micro biopsy tool  310  is inserted into tissues(not shown) in order to pick a tissue sample. After that, as shown in  FIG. 10E , it is possible to pick a tissue sample by moving the fixing body  324  in the rear direction along the ‘C’ path.  
         [0075]      FIG. 10F  shows that the fixing body  324  has moved in state in which is capable of separating the micro biopsy tool  310  from it. After completing the picking of tissue, the protrusion  325  being on the ‘C’ path is moved in the front direction along the ‘B’ path and ‘A’ path sequentially, so that the cover part  321  of the fixing body  324  is to be protruded outside of the external cover  330 . And then, the micro biopsy tool  310  can be separated from the fixing body  324  by opening the cover part  321 .  
         [0076]     External covers  420 ,  430  being a separate type according to another embodiment of the invention is shown in  FIG. 11A . In  FIG. 11A , the cover  420  of the external covers is formed with a recess  421  of “         ” shape and the other cover  430  is formed with a protrusion  431  of circular shape, and thereby recess  421  and the protrusion  431  may form a concavo-convex structure to each other. Therefore, the two covers  420 ,  430  can preserve an stable combination state by the coupling of the recess  421  and the protrusion  431 .  FIG. 11B  shows a combination state of the upper cover  420  and the lower cover  430 .  
         [0077]      FIG. 12A  shows the fixing body  324  adopted in the catheter of  FIG. 10A . As shown in  FIG. 12A , a recess  326  is formed on a base part  322  of the fixing body  324  for putting a micro biopsy tool thereon, and another recess having identical shape with the recess  326  is also formed on a cover part  321 . The cover part  321  may be combined with the base part  322  through a pin  323 , so that the cover part  321  may rotate to the base part  322  within a prescribed angles, and thereby the micro biopsy tool  310  can be easily separated/combined. A hole  327  may be formed for combination with the regulating wire  340  (referring to  FIG. 10A ) through a pin. As described in the above, the protrusion  325  formed on the surface of the fixing body  324  moves along the path of the recess  331 , and thereby enables the fixing body  324  to move stably in the external cover.  
         [0078]      FIG. 12B  shows that a micro biopsy tool is mounted to the fixing body  324  of  FIG. 12A . As shown in  FIG. 12B , the micro biopsy tool  310  can be fixed to the fixing body  324  by closing the cover part  321  when the micro biopsy tool  310  is put on the base part  322  of the fixing body  324 .  
         [0079]      FIG. 13A  shows a fixing body  400  according to another embodiment of the invention. For the fixing body  400  of  FIG. 13A , a micro biopsy tool  410  may be fixed by being inserted between recesses  422 ,  432  formed on two semicircular columns  420 ,  430 , respectively. Like this, while the recesses  422 ,  432  are formed on two semicircular columns  420 ,  430 , respectively, a recess  424  is formed on surface of one column  420  and a protrusion  434  is formed on surface of another column  430 , so that two semicircular columns  420 ,  430  have a stable combination to each other. Hereby, two semicircular columns  420 ,  430  may have a concavo-convex structure to each other. In  FIG. 13A , the recess  426  formed on the rear part of the fixing body  420  is to mount a regulating wire.  
         [0080]      FIG. 13B  shows the fixing body  400  of  FIG. 13A  mounting the micro biopsy tool  410 .  
         [0081]      FIG. 14A  shows a fixing body  500  according to another embodiment of the invention. In the embodiment of  FIG. 14A , the micro biopsy tool  510  is inserted into a recess of specific shape formed on front surface of the fixing body  500 . In this case, the micro biopsy tool  510  may be stably fixed with the fixing body  500  by applying adhesives to a corresponding part  512  of the micro biopsy tool  510  or ultrasonic welding.  
         [0082]      FIG. 14B  shows that the micro biopsy tool  510  is mounted to the fixing body  520  of  FIG. 14A .  
         [0083]      FIG. 15A  shows that the first fixing body  632  is combining with the combining part  641  of the regulating wire  640  according to another embodiment of the invention. In the embodiment of  FIG. 15A , the first fixing body  632  may be combined with the regulating wire  640  by welding, and a bolt  631  for combining with the second fixing body  620  may be formed at an end of the first fixing body  632 .  
         [0084]      FIG. 15B  shows that the first fixing body  632  and the regulating wire  640  combined to each other according to the embodiment of  FIG. 15A  are contained in an external cover  630 .  
         [0085]      FIG. 15C  shows to combine the second fixing body  620 , which mounts a micro biopsy tool, with the first fixing body  632  through the bolt  631  formed at an end of the first fixing body  632 . As shown in  FIG. 15C , a hole  621 , which has screw line therein for combining with the bolt  631 , may be formed in an inner part of the second fixing body  620 .  
         [0086]      FIG. 15D  shows a catheter  600  constructed by the combination of the first fixing body  632  and the second fixing body  620  according to the embodiment of  FIG. 15C . In case using the catheter  600  of  FIG. 15D , a tissue sample may be picked through simple manipulation to move the regulating wire  640  reciprocally, as the catheters according to other embodiments described in the above.  
         [0087]     Like this, when using the catheter of the invention, it is possible to pick the tissue sample just by inserting and extracting the biopsy tool into and from the tissue cell. Accordingly, the picking process can be performed more easily than the picking method using the needle and forceps according to the prior art.  
         [0088]     As described above, the catheter according to the invention picks the tissue with one invasion, thereby minimizing an examinee&#39;s pain due to the tissue picking.  
         [0089]     In addition, since it is possible to easily mount and separate the micro biopsy tool, even after a medical treatment, the catheter can be reused for another medical treatment by replacing the micro biopsy tool only. Accordingly, the invention has a superior advantage from a point of view of an efficient use of resources.  
         [0090]     Additionally, since the catheter can pick the tissue sample with only one invasion, such as just by inserting and extracting the biopsy tool into and from the tissue cell, even an operator who lacks an experience in the tissue picking can easily pick the tissue.  
         [0091]     While the invention has been shown and described with reference to certain preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.