Abstract:
A biochip detection system may comprise a motion execution system, a fluid control system, a temperature control system, an air knife cleaning device, a biochip scanning system and a computer control system which are mounted in a system case. The computer control system may control the motion execution system, the fluid control system, the temperature control system, the air knife cleaning device and the biochip scanning system via electrical connections. The biochip detection system may compactly integrate all executive mechanisms and control devices within a small case, achieving complete isolation and fully automated execution in a detection process and completing all the following detection steps in one operation: sampling, washing, cleaning, heating, cooling, scan imaging, etc., thus effectively improving the detection accuracy while greatly reducing manual operations in the entire process.

Description:
FIELD OF THE INVENTION 
       [0001]    The present invention relates to medical detection equipment, and in particular to a biochip detection system. 
       BACKGROUND OF THE INVENTION 
       [0002]    At present, a detection work of a biochip requires of work processes with multiple steps including sampling, washing, reacting, heating, cooling, cleaning, scan imaging, etc., due to various devices and instruments related thereto, the detection efficiency is very low. Moreover, the detection results are extremely easy to be influenced by manual operation and environmental change during the processes, so, people have been making continuous efforts to design a set of perfect detection system for the detection of the biochip, in order to be more convenient for completing all the processes in a detection process, to reduce workload, working hours and manual misoperation to an extreme, to improve the control accuracy of the detection results, to enhance the work efficiency and to save the consumption of reagents. 
         [0003]    For achieving the normal operation of a biochip detection system requiring of many operation equipment and detection and preparation devices, an electronic control device configured to connect the operation equipment and detection and preparation devices and a computer control system, the full automation in the detection process may be correctly and efficiently achieved by improving cooperation between a mechanical portion and an electric control portion. Some biochip detection systems in the prior art, regarding an open operation desk as a platform for carrying out detection of the biochip, are not easy to be moved but are large in volume resulted in larger occupied space; all the processes for a sample may not be completed directly on a single device during a working process, but the sample needs to be manually transferred to several process equipment, as a result, the system may not achieve automatic operation or keep enough isolation from the outside all the time, thereby easily influencing the detection results. 
       SUMMARY OF THE INVENTION 
       [0004]    In order to overcome the defects of the existing art, the present invention provides a biochip detection system, providing batch detections with high isolation, high efficiency and high accuracy for biochip detection, without manual sample manipulation during the detection. 
         [0005]    A technical solution employed by the present invention to solve the technical problems can be described as follows. 
         [0006]    A biochip detection system according to the invention comprises a motion execution system, a fluid control system, a temperature control system, an air knife cleaning device, a biochip scanning system and a computer control system, which are mounted within a system case. 
         [0007]    Specifically, the motion execution system comprises an X-axis linear execution mechanism, a Y-axis linear execution mechanism and a Z-axis linear execution mechanism, which are arranged perpendicularly to each other along a X-axis direction, a Y-axis direction and a Z-axis direction respectively, wherein the X-axis linear execution mechanism is fixedly mounted on one side of the system case in the Y-axis direction, and comprises a first mobile seat movable along the X-axis direction. The Y-axis linear execution mechanism is arranged above the X-axis linear execution mechanism, secured to the first mobile seat by one end thereof, and provided with a mobile bracket on another end thereof. The motion execution system further comprises a guide rail parallel with the X-axis linear execution mechanism and arranged on another side of the system case in the Y-axis direction, wherein the mobile bracket is slidably mounted on the guide rail by a bottom end thereof, the X-axis linear execution mechanism drives the Y-axis linear execution mechanism to move in a form of a gantry. The Y-axis linear execution mechanism comprises a second mobile seat moveable along the Y-axis direction mounted thereon, the Z-axis linear execution mechanism is vertically mounted on the second mobile seat from one side of the Y-axis linear execution mechanism, and the Z-axis linear execution mechanism comprises a third mobile seat moveable along the Z-axis direction mounted thereon. 
         [0008]    The fluid control system comprises a plurality of miniature pumps configured to suck liquid, fine control valves configured to control flow rate, and liquid adding pipes configured to connect the miniature pumps and the fine control valves for transferring the liquid, wherein the miniature pumps and the fine control valves are respectively mounted on a mounting box and a mounting plate which are fixedly connected to the second mobile seat and the third mobile seat respectively. The mounting box is provided with a plurality of liquid bottles for containing the liquid, the miniature pumps are connected to the liquid bottles and the fine control valves respectively through the liquid adding pipes. The fluid control system further comprises a sampling needle plate mounted on a bottom end of the mounting plate, and pipe orifices of the liquid adding pipes are concentratedly fixed on the sampling needle plate. 
         [0009]    The temperature control system comprises an upper heating plate and a lower heating plate which are abutted with each other, and a rotating shaft device through which one end of the upper heating plate and one end of the lower heating plate are hingedly connected. The upper heating plate is openable and closable along with the rotation of the rotating shaft device, and the lower heating plate is fixedly connected to the system case. The rotating shaft device is arranged on one side of the system case in the X-axis direction, and provided with a motor arranged therein for driving the rotating shaft device to rotate. The Y-axis linear execution mechanism has an original position set on another side of the system case in the X-axis direction. The temperature control system further comprises first heating elements arranged on both of the upper heating plate and the lower heating plate correspondingly for heating, the lower heating plate is further provided with a plurality of clamping grooves for receiving the biochips, corresponding to the first heating elements. The temperature control system further comprises temperature sensors configured to detect the temperature, and a heat radiator arranged below the lower heating plate. 
         [0010]    The air knife cleaning device comprises an air knife mounted on a bottom end of the third mobile seat, and an air pump arranged below the original position of the Y-axis linear execution mechanism, wherein the air pump is connected to the air knife through an air pipe and an electromagnetic switch valve for controlling air flow. 
         [0011]    The biochip scanning system comprises a video camera and an intensifying device which are mounted on the third mobile seat. 
         [0012]    The computer control system comprises a display, a computer, an electrical electronic controller and a manipulating device, controlling the motion execution system, the fluid control system, the temperature control system, the air knife cleaning device and the biochip scanning system via electrical connections. 
         [0013]    As an improvement to the technical solution, the system case consists of an execution case and an electronic control case. The motion execution system, the fluid control system, the temperature control system, the air knife cleaning device and the biochip scanning system are all mounted in the execution case, while the computer control system is mounted in the electronic control case. The execution case and the electronic control case are provided with several connection port groups detachable quickly through cables in a matching manner, and the execution case is further provided with an opening mechanism capable of opening and closing. 
         [0014]    As a further improvement to the technical solution, the opening mechanism is hinged on the execution case in a rotating manner, a gas spring is connected between the opening mechanism and the execution case, and a light tube configured to illuminate is arranged inside the execution case. 
         [0015]    Further, a motor and a screw rod driven by the motor are arranged in each of the X-axis linear execution mechanism, the Y-axis linear execution mechanism and the Z-axis linear execution mechanism. The first mobile seat, the second mobile seat and the third mobile seat are respectively connected to the screw rods of the X-axis linear execution mechanism, the Y-axis linear execution mechanism and the Z-axis linear execution mechanism. The Y-axis linear execution mechanism is further provided with a first drag chain and a second drag chain for protecting the movement of the cables and the air pipes, and the two ends of the first drag chain are respectively connected to the Y-axis linear execution mechanism and the system case. The second drag chain is arranged along the Y-axis linear execution mechanism, of which the two ends are respectively connected to the Y-axis linear execution mechanism and the second mobile seat. 
         [0016]    Further, the mounting box is further provided with a waste liquid bottle, a liquid suction pump, a liquid suction valve for recycling waste liquid, and a cleaning solution bottle and a cleaning solution pump for providing cleaning solution to the liquid adding pipes for cleaning, and a plurality of double check valves accordingly connected between the fine control valves and the miniature pumps. The waste liquid bottle is connected to the liquid suction pump through a waste liquid pipe, a tail end of the waste liquid pipe is fixed on the sampling needle plate, passing through the liquid suction pump. The cleaning solution bottle is connected to the cleaning solution pump through a cleaning solution pipe, then connected in parallel to the double check valves and finally connected to the liquid adding pipes. The system case is provided with a cleaning bottle located below the original position of the Y-axis linear execution mechanism. 
         [0017]    Further, the first heating elements of the lower heating plate are fastened and abutted on the bottom surface of the lower heating plate, and the temperature sensor is arranged in the center of the bottom surface of the lower heating plate. The lower heating plate is further provided with a travel switch configured to control the heating of the heating plates, and a circular groove which encircles the clamping grooves and receives an elastic sealing strip. In the clamping grooves, inclined planes which facilitate taking the biochips out are arranged. The heat radiator is provided with a plurality of fans  36  for blowing air in a direction directly facing the bottom surface of the lower heating plate, and corresponding to the fans, a plurality of vent holes are arranged at the bottom of the system case. 
         [0018]    Further, the rotating shaft device is of a hollow structure, and provided with some axis holes and wire holes for leads passing. 
         [0019]    Further, a filter configured to remove air particles, an air bag configured to store compressed air, and a pressure regulating valve configured to regulate the output pressure, are successively connected between the air pump and the air knife, wherein the pressure regulating valve is further connected to a gas-pressure meter configured to display the gas pressure value in real time. 
         [0020]    Further, the air knife is in a wedge shape, and provided with a plurality of air jet holes and circulating holes which are arranged side by side at a pointed end and two side faces thereof. 
         [0021]    Further, the intensifying device is arranged below the video camera, and provided with a lens and a light source for the video camera. 
         [0022]    The beneficial effects of the present invention are as follows: the product has high integration level, compactly integrates each executive mechanism and control device in a small case, achieves complete isolation and fully automated execution in a detection process and completes all the following detection steps in one operation: sampling, washing, cleaning, heating, cooling, scan imaging, etc., thus effectively improving the detection accuracy while greatly reducing the manual operation of the entire process; moreover, the volume and size thereof are moderate, and therefore the product may be easily transported or transferred and is suitable for hospitals, research institutions or many other places. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0023]    The present invention is further described as below with reference to the accompanying drawings and embodiments. 
           [0024]      FIG. 1  is a schematic view of the system of the invention; 
           [0025]      FIG. 2  is a schematic view of a motion execution system of the invention under a mounting condition; 
           [0026]      FIG. 3  is a schematic view of the motion execution system of the invention under a mounting condition from another point of view; 
           [0027]      FIG. 4  is an internal schematic view of an X-axis linear execution mechanism of the invention; 
           [0028]      FIG. 5  is an internal schematic view of a Y-axis linear execution mechanism of the invention; 
           [0029]      FIG. 6  is a schematic view of a fluid control system of the invention under a mounting condition; 
           [0030]      FIG. 7  is a schematic view of a mounting box of the fluid control system of the invention under a mounting condition; 
           [0031]      FIG. 8  is a schematic view of a temperature control system of the invention under a mounting condition; 
           [0032]      FIG. 9  is a sectional view of a lower heating plate of the invention; 
           [0033]      FIG. 10  is a local sectional view of a rotating shaft device of the invention; 
           [0034]      FIG. 11  is a schematic view of an air knife cleaning device and a biochip scanning system of the invention under a mounting condition; 
           [0035]      FIG. 12  is a structure diagram of a mounting condition of components such as an air pump in the air knife cleaning device of the present invention; 
           [0036]      FIG. 13  is a schematic view of an air knife of the invention; 
           [0037]      FIG. 14  is an exploded view of the temperature control system of the invention under a mounting condition; 
           [0038]      FIG. 15  is a back view of a lower heating plate of the temperature control system of the invention; and 
           [0039]      FIG. 16  is a back view of an upper cover plate of the temperature control system of the invention. 
       
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENT 
       [0040]    As shown in  FIG. 1  to  FIG. 16 , a biochip detection system according to the invention comprises a motion execution system, a fluid control system, a temperature control system, an air knife cleaning device, a biochip scanning system and a computer control system which are mounted in a system case  9 . These sub systems are compactly integrated in the system case  9  to carry out various detection processes and provide better protection in movement or transportation. As all are integrated in one as a whole, the system is controlled in size and thus its applicability is enhanced. The system case  9  may be provided with a structure such as cabin door or window to place the biochips therein. 
         [0041]    The motion execution system comprises an X-axis linear execution mechanism  11 , a Y-axis linear execution mechanism  12  and a Z-axis linear execution mechanism  13 , arranged perpendicularly to each other along an X-axis direction, a Y-axis direction and a Z-axis direction respectively. The X-axis linear execution mechanism  11  is fixedly mounted on one side of the system case in the Y-axis direction, and comprises a first mobile seat  111  movable along the X-axis direction. The Y-axis linear execution mechanism  12  is arranged above the X-axis linear execution mechanism  11 , secured to the first mobile seat  111  by one end thereof, and provided with a mobile bracket  122  on another end thereof. The motion execution system further comprises a guide rail ( 14 ) parallel with the X-axis linear execution mechanism  11  and arranged on another side of the system case  9  along the Y-axis direction, wherein the mobile bracket  122  is slidably mounted on the guide rail  14  by a bottom end thereof, the X-axis linear execution mechanism  11  drives the Y-axis linear execution mechanism  12  to move in a form of a gantry. The Y-axis linear execution mechanism  12  further comprises a second mobile seat  121  moveable along the Y-axis direction mounted thereon, the Z-axis linear execution mechanism  13  is vertically mounted on the second mobile seat  121  from one side of the Y-axis linear execution mechanism  12 , and the Z-axis linear execution mechanism  13  comprises a third mobile seat  131  mounted thereon and moveable along the Z-axis direction. The third mobile seat  131  may move arbitrarily within the system case  9  through the movement of the three execution mechanisms, thus allowing a spatial movement and facilitating the mounting of the fluid control system to carry out sampling in batches. 
         [0042]    The fluid control system comprises a plurality of miniature pumps  21  configured to suck liquid, fine control valves  22  configured to control flow rate, and liquid adding pipes  23  configured to transfer liquid and connect the miniature pumps  21  and the fine control valves  22 , wherein the miniature pumps  21  and the fine control valves  22  are respectively mounted on a mounting box  241  and a mounting plate  242  which are respectively fixedly connected to the second mobile seat  121  and the third mobile seat  131 . The mounting box  241  is provided with a plurality of liquid bottles  211  loaded with the liquid arranged thereon. Correspondingly, the miniature pumps  21  are connected to the liquid bottles  211  and the fine control valves  22  through the liquid adding pipes  23 , respectively. The fluid control system further comprises a sampling needle plate  25  mounted on a bottom end of the mounting plate  242 , and the pipe orifices of the liquid adding pipes  23  are concentratedly fixed on the sampling needle plate  25 . The entire fluid control system is moved along with the Z-axis linear execution mechanism  13  in real time, in which all the liquid adding pipes  23  will not extend-retract or swing with the sampling needle plate  25 . The mounting box  241 , the mounting plate  242 , as well as the liquid bottles  211 , the miniature pumps  21  and the fine control valves  22  of a number as required, and the liquid adding pipes  23  connected, allow a fast and accurate sampling process. 
         [0043]    The fluid control system further comprises a liquid suction pump  26  configured to suck the sampled liquid. The liquid suction pump  26  is connected to a waste liquid bottle  261  configured to recycle the waste liquid and the fine control valves  22  through liquid suction pipes. The tail ends of the liquid suction pipes passing through the fine control valves  22  are fixed on the sampling needle plate  25 . Since the biochips will only react with an extremely small amount of the sampling liquid during the process of sampling the liquid droplet, and the liquid droplet may be sucked back by the liquid suction pipes instantly, the pollution and adverse effects on the samples detected are avoided. Moreover, the liquid adding pipes  23  for sampling the liquid droplet may be cleaned by the cleaning solution flowing through the liquid adding pipes, and the cleaning solution flowed out from the liquid adding pipes  23  is recycled in the waste liquid bottle  261  through the liquid suction pipes, thus achieving an automatic control on the liquid treatment. 
         [0044]    Preferably, the liquid bottles  211  and the waste liquid bottle  261  are placed on a mounting box  241 , and a mounting base on which the miniature pumps  21  and the liquid suction pump  26  are mounted is arranged on the mounting box  241 . The fine control valves  22  and the sampling needle plate  25  are respectively fixedly connected to a middle section and a bottom end of the mounting plate  242 , the mounting plate  242  and the mounting box  241  are fixed on a mobile manipulator moveable spatially. The mounting plate  242  is vertically connected to one side of a bottom end of the mobile manipulator, and the mounting box  241  is connected to one side of a top end of the mobile manipulator. On the one hand, the liquid bottles  211 , the waste liquid bottle  261 , the miniature pumps  21  and the liquid suction pump  26  may respectively move along with the mobile manipulator by means of the mounting box  241  and the mounting base. On the other hand, the fine control valves  22  and the sampling needle plate  25  are fixed on a bottom end of the mobile manipulator by the mounting plate  242 , such that the entire fluid control system is integrated on the mobile manipulator to facilitate the sampling of liquid droplet, as well as to enable the liquid adding pipes  23  and the liquid suction pipes to work more accurately, and further to facilitate the changing of the liquid bottles  211  and the waste liquid bottle  261 . 
         [0045]    Further, the liquid adding pipes  23  between the miniature pumps  21  and the fine control valves  22  are further provided with double check valves  29  which select the pipes for liquid passing through. The double check valves  29  are simultaneously connected with two liquid adding pipes  23  for transferring the cleaning solution and the sampling liquid respectively. The liquid adding pipe  23  for transferring the cleaning solution is connected to a cleaning pump configured to supply the cleaning solution alone, the two liquid adding pipes  23  passing through the double check valves  29  are jointed in parallel into one and then connected in parallel to the fine control valves  22 . Thus, as long as one liquid bottle  211  loaded with the cleaning solution is arranged, it may achieve transferring the cleaning solution to each of the liquid adding pipes  23  by in parallel connecting the liquid adding pipes  23  to each of the double check valves  29  through the cleaning pump. 
         [0046]    Furthermore, the double check valves  29  together with the fine control valves  22  which is connected to the liquid suction pump  26  are mounted on the mounting base. 
         [0047]    The system is further provided with a liquid containing bottle which is configured to correspondingly receive the liquid drained from the liquid adding pipes  23  and arranged below the mobile manipulator. The liquid containing bottle may be used in the test of the liquid adding pipes  23  for transferring liquid or recycling the spot sample liquid and the cleaning solution, so as to keep the medical detection equipment clean. 
         [0048]    Further, the liquid containing bottle is arranged below the mobile manipulator at its original position, to avoid liquid leakage of the liquid adding pipes  23  influencing the interior of the medical detection equipment when the mobile manipulator is in the original position. In addition, the original position is the most appropriate place to arrange the liquid containing bottle, thus facilitating other execution mechanisms of the medical detection equipment. 
         [0049]    The temperature control system for medical detection equipment comprises a lower heating plate  32 , an upper heating plate  31 , a driving device and a heat radiator. The lower heating plate  32  is fixedly mounted within the case of the medical detection equipment. The temperature control system further comprises a first heating element  34  for heating, mounted on a lower end face of the lower heating plate  32 . The lower heating plate  32  has a heating region in a position on an upper end face thereof corresponding to where the first heating element  34  is located, on which clamping grooves  321  where the biochips are placed are arranged. The upper heating plate  31 , which may be opened and closed relative to the lower heating plate  32 , is hingedly mounted on one end of the lower heating plate  32 . The driving device is configured to drive the upper heating plate  31  to rotate, comprising a motor  381  and a transmission mechanism  382 . The heat radiator is arranged below the lower heating plate  32 , comprising a radiator mounting rack  362  fixedly connected to the lower heating plate  32 , and a plurality of radiator fans  36  mounted on the radiator mounting rack  362 . The radiator mounting rack  362  is provided with a plurality of vent holes  363  in positions corresponding to where the radiator fans  36  are arranged. Preferably, a fixing plate  38  is fixedly connected to and arranged below the radiator mounting rack  362 , the heat radiator and the lower heating plate  32  may be mounted in the case through a fixed connection of the fixing plate  38  to the case of the medical detection equipment. A heat radiating mechanism  383  configured to facilitate air to enter is arranged in a position of the fixing plate  38  corresponding to where the radiator fans  36  are arranged. During heat dissipating, the air goes into the radiator fans  36  from outside through the heat radiating mechanism  383  on the fixing plate  38  and the vent holes  363  on the radiator mounting rack  362  after entering the case, and then is blown to the first heating elements  34  by the radiator fans  36 . 
         [0050]    In the present invention, the upper heating plate  31  is hingedly mounted on the lower heating plate  32 , and the transmission mechanism  382  is driven by the motor  381  to rotate the upper heating plate  31 , thus achieving the opening and closing operations of the upper heating plate  31  with respect to the lower heating plate  32 . The invention has the advantages of simple and compact structure, small size, low production costs and easy operation without manually opening and closing the upper heating plate  31 . The upper heating plate  31  is lidded on the lower heating plate  32  during heating, effectively reducing heat loss and waste, and providing higher heating efficiency. Moreover, the heat radiator is arranged below the lower heating plate  32 , the air flow blown out from the radiator fans  36  is immediately in contact with the first heating elements  34  fixedly mounted on the lower end face of the lower heating plate  32 , providing excellent heat dissipation effect, i.e. quickly dissipating the heat on the lower heating plate  32  to avoid over-temperature, prolonging service life, preventing users from being scalded, and enhancing safety. 
         [0051]    Further, for higher heating efficiency and to prevent the heat from leaking from a slit between the upper heating plate  31  and the lower heating plate  32 , the lower heating plate  32  is provided with a circular groove  322  formed on a periphery of the heating region thereof, and an elastic sealing element embedded into the circular groove  322 . The elastic sealing element is pressed by the lower heating plate  32  to deform so as to seal the heating region when the upper heating plate  31  is closed on the lower heating plate  32 . During heating, the upper heating plate  31  is rotated to lid on the lower heating plate  32 , and presses the elastic sealing element under the effect of gravity to deform, so as to seal the heating region. This arrangement is characterized in an excellent sealing effect and consequently an excellent heating effect as the temperature in the heating region may stay the same. 
         [0052]    Further, the clamping groove  321  is provided with a bevel  323  sloping downward on a upper bottom surface at one end thereof to facilitate the article heated to escape from the clamping groove  321  from another end opposite to said end while the article is pressed at said end. With this structure, a user may manually take the heated article out from the clamping groove  321  by pressing the heated article at one end of the clamping groove  321  where the bevel  323  is provided to upwarp the heated article at another end, without the aid of a tool, the manipulation is rapid and convenient. 
         [0053]    Further, the upper heating plate  31  is flexibly connected to one end of the lower heating plate  32  through the rotating shaft device  33 , and the rotating shaft device  33  is flexibly connected to a first supporting seat  391  and a second supporting seat  392  through bearings on two ends thereof. The first supporting seat  391  is close to the motor  381  and fixedly mounted on the lower heating plate  32  along with the second supporting seat  392 . The two ends of the rotating shaft device  33  are mounted through bearings on the first supporting seat q 391  and the second supporting seat  392  on the lower heating plate  32 , thus reducing friction generated during the opening and closing processes of the upper heating plate  31 , and prolonging the service life of the device of the present invention. Preferably, in order to facilitate the mounting of the driving device, a mounting flange  324  for fixedly mounting a motor  381  is arranged on one end of the lower heating plate  32  where the rotating shaft device  33  is connected, and a notch  325  is formed on one side of the lower heating plate  32  where the mounting flange  324  is mounted. The rotating shaft device  33 , the first supporting seat  391  and the second supporting seat  392  are all arranged in the notch  325 . The driving device is a reduction gear set and mounted in the first supporting seat  391 , such that the system has a compact integral structure and aesthetic appearance, and facilitates laying leads. 
         [0054]    Further, for higher heating efficiency of the heating system, the system further comprises a second heating elements  312  mounted in a position on a back side of the upper heating plate  31  corresponding to where the first heating element  34  is located, a shield plate  301  fixedly connected to the upper heating plate  31  and arranged on another side of the second heating element  312 , and a heat insulating strip  302  arranged between the shield plate  301  and the upper heating plate  31 . This structure is characterized in higher heating efficiency by arranging the second heating element  312  on the back side of the upper heating plate  31  and heating the articles to be heated in the clamping grooves  321  with the first heating element  34  and the second heating element  312  together. In the embodiment, the second heating element  312  may be a heating plate with built-in heating wire and glued on a back side of the upper heating plate  31  through adhesive, while the first heating element  34  is also a heating plate with built-in heating wire and glued on a back side of the lower heating plate  32  through adhesive. With this arrangement, the first heating element  34  and the second heating element  312  are both heating-wire-built-in heating plates, their heating wires are unexposed to the outside, and thereby providing safety and cleanness. Moreover, the heating plates on the upper heating plate  31  and the lower heating plate  32  are fixed through the adhesive, thus it facilitates mounting. 
         [0055]    Further, the rotating shaft device  33  is provided with a first slot and a second slot formed on the outer surface thereof along an axial direction thereof, accordingly the upper heating plate  31  and the shield plate  301  are respectively provided with a first flange  311  matched to the first slot, and a second flange  303  matched to the second slot, which the two flanges are fixed on the rotating shaft device  33  by screws after inserted into the corresponding slots. This structure is convenient for disassembly and assembly and maintenance, the upper heating plate  31  and the shield plate  301  are fixedly connected to the rotating shaft device  33  by means of the first flange  311  and the second flange  303 , such that the connection between the upper heating plate  31  and the rotating shaft device  33  are firmer and more reliable, thereby preventing the first flange  311  from fracture under the force of gravity of the shield plate  301  and the upper heating plate  31 . 
         [0056]    Further, the rotating shaft device  33  is of a hollow structure, and provided with some wire through holes  332  for wiring on a portion thereof between the first slot and the second slot, which are connected to a hollow cavity  331  of the rotating shaft device  33 . Due to this, the leads connected with the second heating element  312  are encapsulated in an inner cavity formed by the shield plate  301 , the heat insulating strip  302  and the upper heating plate  31 , and led to the lower heating plate  32  through the wire through holes  332  and the hollow cavity  331  of the rotating shaft device  33 . This facilitates wiring while avoiding the leads from being exposed, increases the aesthetic extent of appearance of the heating plates, effectively avoids wire winding, prolongs the service life of the leads, and facilitates the long-term safe operation for heating plate. 
         [0057]    Further, in order to improve the automaticity of the heating system, one or more temperature sensors configured to sense the heating temperature are mounted on the lower heating plate  32 . Preferably, the present invention further comprises a temperature controller configured to control the heating temperature. Here, the number and the mounting position of the temperature sensors are not limited, but may be configured flexibly according to actual needs. In an embodiment, an elongated slot  326  in which the temperature sensor is embedded is formed on the back side of the lower heating plate  32 . During heating, the heating system may detect the temperature of the lower heating plate  32  in real time by means of the temperature sensor, and transmit signals to the temperature controller to switch on and off the heating elements and/or adjust the power supplied to the heating elements of the heating system, by comparing the real-time measured temperature with a preset temperature, thus achieving constant temperature heating on the articles to be heated. 
         [0058]    Further, a travel switch  37 , which is triggered by the upper heating plate  31  when the upper heating plate  31  is closed with respect to the lower heating plate  32 , is mounted on the upper end face of the lower heating plate  32  in a protruding manner. Only when the upper heating plate  31  is lidded on the lower heating plate  32 , the travel switch  37  is triggered by the upper heating plate  31  and the heating system is turned on for heating, avoiding the scalding accidents caused by the upper heating plate  31  and the lower heating plate  32  being started to heat while the upper heating plate  31  and the lower heating plate  32  are not closed, the safety in use of the heating system is thus guaranteed. 
         [0059]    When the present invention is applied to gene sequencing, firstly, the biochips are placed in the clamping grooves  321 , reagent is added to the biochips manually or with the aid of other automatic devices, after that the excess reagent is cleaned away, and then the motor  381  is turned on to drive the rotating shaft device  33  to rotate with the help of the reduction gear set, thus the upper heating plate  31  is closed with respect to the lower heating plate  32 . When the upper heating plate  31  is closed with respect to the lower heating plate  32 , the travel switch  37  is triggered by the upper heating plate  31  to turn on the heating system for heating automatically, and the temperature of the lower heating plate  32  is detected in real time through the temperature sensor. The system controls the temperature of the lower heating plate  32  into a certain range to achieve constant temperature heating on the biochips. The invention has a simple and compact structure, and relatively low production costs. The invention provides an automatic opening and closing mechanism for more conveniences in operation. 
         [0060]    The upper heating plate  31  and the lower heating plate  32  are hinged together through a rotating shaft device  33 , the upper heating plate  31  may be opened and closed along with the rotation of the rotating shaft device  33 . The lower heating plate  32  is fixedly connected to the system case  9 . The rotating shaft device  33  is arranged on one side of the system case  9  in the X-axis direction, and a motor for driving the rotating shaft device  33  to rotate is arranged therein. The original position of the Y-axis linear execution mechanism  12  is set on another side of the system case  9  in the X-axis direction, the first heating elements  34  for heating are arranged on both of the upper heating plate  31  and the lower heating plate  32  correspondingly. Corresponding to the first heating elements  34 , the lower heating plate  32  is further provided with a plurality of clamping grooves  321  where the biochips are placed, and temperature sensors  35  configured to detect the temperature. A heat radiator is arranged under the lower heating plate  32 . The lower heating plate  32  is configured as an operation desk for accommodating the biochips during a complete biochip detection process, the biochip detection procedures such as sampling, heating and scanning are all conducted on the lower heating plate  32 . In the heating process, the upper heating plate  31  is lidded on the lower heating plate  32  along with the rotation of the rotating shaft device  33 , thus achieving rapid heating and temperature control. 
         [0061]    The air knife cleaning device comprises an air knife  41  mounted on a bottom end of the third mobile seat  131 , and an air pump  42  arranged in a position below the original position of the Y-axis linear execution mechanism  12 . The air pump  42  is connected to the air knife  41  through an air pipe and an electromagnetic switch valve configured to control the air flow. The compressed air produced by the air pump  42  is jetted at a high speed through the air knife  41  to blow away the residual sampling liquid on the surface of the biochips instantly, thus protecting the biochip from being polluted. 
         [0062]    The biochip scanning system includes a video camera  51  and an intensifying device  52  which are mounted on the third mobile seat  131 . The video camera  51  scans the biochips and transmit the pattern information gained to the computer control system for analysis and comparison. The intensifying device  52  plays a role of supplementing light source to ensure a successful scanning of the video camera  51 . 
         [0063]    The computer control system, comprised of a display, a computer, an electrical electronic controller and a manipulating device, controls the motion execution system, the fluid control system, the temperature control system, the air knife cleaning device and the biochip scanning system via electrical connections. 
         [0064]    As a further improvement on the abovementioned embodiments, the system case  9  consists of an execution case  91  and an electronic control case  92 . The motion execution system, the fluid control system, the temperature control system, the air knife cleaning device and the biochip scanning system are all mounted in the execution case  91 , while the computer control system is mounted in the electronic control case  92 . The execution case  91  and the electronic control case  92  are provided with a plurality of connection port groups quickly detachable via cables, and the execution case  91  is further provided with an opening mechanism  911 . The detachable design of the system case  9  further improves applicability and flexibility of the detection system. 
         [0065]    As a further improvement on the abovementioned embodiments, preferably, the opening mechanism  911  is hinged on the execution case  91  in a rotating manner, a gas spring  912  is connected between the opening mechanism  911  and the execution case  91 . A light tube for illumination is arranged within the execution case  91 , and the execution case  91  and the electronic control case  92  are further provided with handle grooves at both sides thereof for facilitating transferring. 
         [0066]    Further, a motor and a screw rod driven by the motor are arranged in each of the X-axis linear execution mechanism  11 , the Y-axis linear execution mechanism  12  and the Z-axis linear execution mechanism  13 . The first mobile seat  111 , the second mobile seat  121  and the third mobile seat  131  are respectively connected to the screw rods of the X-axis linear execution mechanism  11 , the Y-axis linear execution mechanism  12  and the Z-axis linear execution mechanism  13 . The Y-axis linear execution mechanism  12  is further provided with a first drag chain  123  and a second drag chain  124  for protecting the movement of the cables and the air pipes. The two ends of the first drag chain  123  are respectively connected to the Y-axis linear execution mechanism  12  and the system case  9 . The second drag chain  124 , of which the two ends are respectively connected to the Y-axis linear execution mechanism  12  and the second mobile seat  121 , is arranged along the Y-axis linear execution mechanism  12 . Cables and air pipes may be connected to the Y-axis linear execution mechanism  12  from the system case  9  along the first drag chain  123 , and connected to other components such as the mounting box  241  along the second drag chain  124 , and thus are protected. 
         [0067]    Further, the mounting box  241  is further provided with a waste liquid bottle  261  configured to recycle waste liquid, and a liquid suction pump  26 , a liquid suction valve  27 , a cleaning solution bottle  281  and a cleaning solution pump  28  which are configured to provide cleaning solution to the liquid adding pipes  23  for cleaning, and a plurality of double check valves  29  connected between the fine control valves  22  and the miniature pumps  21  in a matching manner. The waste liquid bottle  261  is connected to the liquid suction pump  26  through a waste liquid pipe  262 , passing through the liquid suction pump  26 , the waste liquid pipe  262  is fixed on the sampling needle plate  25  with a tail end thereof. The cleaning solution bottle  281  is connected to the cleaning solution pump  28  through a cleaning solution pipe  282 , then connected in parallel to the double check valves  29  and finally connected to the liquid adding pipes  23 . The system case  9  is provided with a cleaning bottle  283  located below the Y-axis linear execution mechanism  12  in the original position. By the double check valves  29 , the liquid adding pipes  23  may be cleaned by the cleaning solution, selectively, and the cleaning solution is drained into the cleaning bottle  283  from the liquid adding pipes  23  to be stored temporarily, and then sucked into the waste liquid bottle  261  through the waste liquid pipe  262 , meanwhile the waste liquid pipe  262  is also capable of sucking the liquid left on the biochip during sampling, and then the air knife cleaning device is turned on for cleaning, thus the amount of the liquid splashed into the system case  9  is reduced and consequently the pollution is reduced. 
         [0068]    Further, the first heating elements  34  of the lower heating plate  32  are firmly abutted on the bottom surface of the lower heating plate  32 , the temperature sensor  35  is arranged in the center of the bottom surface of the lower heating plate  32 . The lower heating plate  32  is further provided with a travel switch  37  configured to control the heating of the heating plates to ensure that the heating operation is carried out only when the upper heating plate  31  is closed with respect to the lower heating plate  32 . Furthermore, the lower heating plate  32  is provided with a circular groove  322  encircling the clamping grooves  321  and receiving an elastic sealing strip. The clamping grooves  321  is provided with inclined planes  323  for facilitating taking out the biochips. The heat radiator is provided with a plurality of fans  36  for blowing air in a direction directly to the bottom surface of the lower heating plate  32 , and a plurality of vent holes corresponding to the fans are arranged at the bottom of the system case  9 , to improve the heat dissipation and ventilating effects. As the biochips are placed on the lower heating plate  32 , the first heating elements  34  (not shown in the drawings) of the upper heating plate  31  may be arranged inside the upper heating plate  31 , in order to avoid a potential defect caused by exposing the first heating elements  34 , e.g., collision with other components, during opening. 
         [0069]    Further, the rotating shaft device  33  is of a hollow structure, and provided with some axis holes and wire through holes  332  for leads passing through, such that the leads may go in from the axis holes, and go out from the wire through holes  332  to connect corresponding components, and thus disordered placement of the leads in the system case  9  is avoided. 
         [0070]    Further, a filter  45  configured to remove particles from air, an air bag  43  configured to store compressed air, and a pressure regulating valve  44  configured to regulate the output pressure are successively connected between the air pump  42  and the air knife  41 , the pressure regulating valve  44  is further connected to a gas-pressure meter for displaying the air pressure value in real time, so as to improve quality and effect of the air jetting of the air knife  41 . 
         [0071]    Further, the air knife  41  is configured in a wedge shape, and provided with a plurality of air jet holes  411  and circulating holes arranged side by side at a pointed end and two side ends thereof. The air jet holes  411  are mainly used to jet air downwards, and the circulating holes generate wind pressure superposition effect, thereby cleaning the liquid or particles on the biochip more thoroughly. 
         [0072]    Further, the intensifying device  52  is mounted below the video camera  51 , comprising a lens and a light source for the video camera  51 . The video camera  51  scans through the lens to avoid dust in air from attaching to the video camera  51  during cleaning. 
         [0073]    The basic operation steps of a biochip detection system of the present invention are as follows. 
         [0074]    Firstly, the biochips are placed on the clamping grooves  321  of the lower heating plate  32 , and then the computer control system is turned on to control each of the systems to carry out detection with a specific control software. The motion execution system drives the fluid control system and the air knife cleaning device to carry out the work processes of sampling and cleaning the biochips. The sampling needle plate  25  and the air knife  24  may move to each of the biochips along with the Z-axis linear execution mechanism  13  to carry out the work processes of sampling and cleaning. After that, the temperature control system controls the temperature, that is to say, the upper heating plate  31  is closed with respect to the lower heating plate  32 , heating the biochips to a specific temperature so as to allow the samples of the biochips to react. After this process, the upper heating plate  31  is opened, and the biochips are cooled to a normal temperature. Finally, after reacted sufficiently, the samples of the biochips is scanned by the biochip scanning system, the sample images gained by the video camera  51  are transmitted to the computer control system, and analyzed and compared with the software thereon, to complete the detection for the biochips. However, each of the work processes may be carried out by a specific or unspecific order, once or repeatedly. 
         [0075]    The above descriptions are preferred embodiments of the present invention only, and the present invention shall not be limited thereto. All embodiments, which achieve the technical effects of the present invention by any same or similar means, should fall into the protection scope of the present invention.