Abstract:
Wearable sensors and cybernetic systems that allow one or more operators to interact and control operations of electronic, mechanical, robotic, or biomedical systems, and methods of use in gynecology, female sexual response and female sexual well-being.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a non-provisional of U.S. Provisional Application 62/095,740 filed on Dec. 22, 2014, the entirety of which is incorporated by reference. 
     FIELD OF THE INVENTION 
     This invention relates to wearable sensors and cybernetic systems that allow at least two individuals to interact and control operations of electronic, mechanical, robotic, or biomedical systems, and methods of use in gynecology, female sexual response and female sexual well-being. 
     BACKGROUND OF THE INVENTION 
     The field of wearable sensors is growing rapidly, with commercial products available for monitoring vital signs such as body temperature, heart rate, and respiration. In a recent report, Lux Research forecast that a new generation of sensors, called PFOE sensors (printed, flexible, organic electronic sensors) are destined for a future in which millions or billions of wirelessly-connected devices will form the much-discussed “internet of things”, a large part of which may be wearable devices, including new medical and athletic wearable devices. 
     This invention relates to the field of systems using wearable sensors, and further includes wearable actuators, wearable control systems and wireless systems for communication between users wearing such systems. In a particular variation, this invention relates to wearable systems with sensors, actuators and control systems adapted for use in medical fields and the field of female sexual response and well-being. 
     In recent years, there has been an increased focus on women&#39;s health relating to sexuality and sexual response. On one track, physicians, researchers and pharmacologists have led a movement toward establishing female sexual dysfunction (FSD) as a new category of disease. In a well known 1999 JAMA study, the authors reported that 43% of surveyed American women experienced sexual dysfunction ( Journal of the American Medical Association , Feb. 10, 1999). In this study, women were considered to have sexual dysfunction if they reported any of the following: lack of sexual desire, difficulty in becoming aroused, inability to achieve orgasm, anxiety about sexual performance, or failure to derive pleasure from sex. Further, the drug industry has attempted to draw parallels between male and female sexual dysfunction, following the success of Viagra (sildenafil) in treating male dysfunction. The success of sildenafil has made women&#39;s sexuality a high-profile research target. 
     On another track, women on their own have found means for addressing the issue of dissatisfaction is their sex life, and it is unlikely that they consider such dissatisfaction to be a disease state. In 2000, critics of categorizing female sexual dysfunction as a disease state were supported by the results of a preliminary study by the Kinsey Institute. The Kinsey data indicated that women considered that their emotional health and personal relationship factors were the most important factors in sexual well-being, rather than a quantitative metric such as achieving orgasm. In the Kinsey survey, women ranked general well-being at the top as a requirement, followed by emotional reactions during sexual activity, the attractiveness of her partner, physical responses during sexual activity, frequency of sexual activity with her partner, and her partner&#39;s sensitivity. 
     It seems likely the incidence of female sexual dysfunction has been exaggerated by parties other than the women themselves. However, there certainly is a lack of sexual well-being that is real for millions of women. In general, in women, sexual response is much more qualitative than in men and relates to desire, arousal, and gratification which cannot be easily observed or measured. 
     Women are taking active measures to enhance satisfaction in their sex life, and it appears that stimulus devices are popular and effective. In the 2005 Durex Global Sex Well-Being Survey it was reported that 43% of US respondents own a vibrator-type stimulus device. Similarly, a 2009 Indiana University study published in the Journal of Sexual Medicine found that 53 percent of all U.S. women have used a vibrator device. 
     Thus, it seems clear that stimulus devices may play a significant role in woman&#39;s sexual well-being. Such well-being is the result of a mind/body collaboration, that is, typically involving two minds and two bodies. What is needed are stimulus systems that are adapted for enhancing sexual response in women, while at the same time providing avenues for improving the personal relationship with her partner. More particularly, what is needed are new forms of stimulus systems that are enabled by discrete wearable sensors and actuators. Further, what is needed are cybernetic stimulus systems that will improve communications between a female and her partner while at the same time providing for optimal stimulus in intimate moments. Further, what is needed are cybernetic stimulus systems with data memory capabilities that are adapted to train or remind the partners of optimal stimulus inputs, or directly provide such inputs from algorithms that access the stored data. 
     The details of several variations of the invention are set forth in the accompanying drawings and the description below. Other features and advantages of the invention will be apparent from the description and drawings, and from the claims. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic view of a glove-like device that carries a plurality of sensors positioned for stretchable actuation by a finger or knuckle joint, with each sensor coupled to a communication unit for sending signals to a control unit. 
         FIG. 2  is an enlarged exploded view of a stretch sensor that comprises a thin film conductive lyriform structure that can be embedded in an elastomer wall. 
         FIG. 3  is an exploded view of another stretch sensor that comprises a thin conductive polymer layer that can be embedded within an elastomer wall. 
         FIG. 4A  is a schematic view of a stimulus system that uses fluid actuators corresponding to the invention with an elevational view of an actuatable device adapted for wearing on a human hand and controllable by finger movement. 
         FIG. 4B  is a phantom view of the stimulus system of  FIG. 4A  disposed about a human wrist, hand and fingers. 
         FIG. 5  is a block diagram of components of the stimulus system of  FIG. 4A , including electrical components, wireless transmission components, controls units and memory units. 
         FIG. 6  is a view of human hand of  FIG. 4B  from a different angle showing finger actuation of stretch sensors of the stimulus system. 
         FIG. 7A  is a chart showing a method of the invention relating to controlling the amplitude of pulses of an actuatable region of the device of  FIG. 4A  over a time interval or episode. 
         FIG. 7B  is a chart showing another method relating to controlling the frequency of pulses of an actuatable region of the device of  FIG. 4A  over an episode or session. 
         FIG. 8  is a chart showing another method relating to controlling the amplitude and frequency of pulses of an actuatable region of the device of  FIG. 4A  over a time interval. 
         FIG. 9  is a schematic view of a stimulus system as in  FIG. 4A  further including a second actuatable device adapted for wearing on a second person&#39;s hand. 
         FIG. 10  is a chart showing another method of the invention relating to two partner&#39;s interactively controlling the amplitude of pulses of an actuatable region of the device of  FIG. 4A  over a time interval. 
         FIG. 11A  is a sectional view of a fluidic actuator region of the device of  FIG. 4A  in a non-actuated position. 
         FIG. 11B  is a sectional view of a fluidic actuator region of  FIG. 11A  in an actuated position. 
         FIG. 12A  is a first component of another variation of a stimulus system that uses fluidic actuation with the component of  FIG. 12A  consisting of a non-disposable glove-like body that carries a drive unit or motor and sensors operated by finger movement. 
         FIG. 12B  is a second component of the stimulus system of  FIG. 12A  with the component of  FIG. 12B  consisting of a disposable glove-like body that carries the fluidic actuator that is detachably coupled to the body of  FIG. 12A . 
         FIG. 13  is another variation of the first component of a stimulus system similar to that of  FIG. 12A . 
         FIG. 14  is a view of another variation of a stimulus system which includes an entirely disposable glove-like stimulus device of the type illustrated in  FIGS. 4A-4B  or  FIGS. 12A-12B  that carries both sensors and actuatable regions. 
         FIG. 15  is a schematic view of another variation of a stimulus system which includes a glove-like device of the type illustrated in  FIGS. 4A-4B  that has a control unit that is adapted to receive music signals and controller algorithms that can modulate applied stimulus in response to aspects of music. 
         FIG. 16A  is a schematic view of another variation of a stimulus system which includes a glove-like device that carries a suction source that communicates with ports in the actuator region to suction tissue against the actuator surface. 
         FIG. 16B  is a sectional view of the actuator region with an undulating surface of the device of  FIG. 16A  taken along line  16 B- 16 B. 
         FIG. 16C  is a sectional view of another actuator region of the device of  FIG. 16A  similar to that of  FIG. 16B . 
         FIG. 17  is an enlarged sectional perspective view of the undulating actuator surface of  FIG. 16B  showing suction ports and flow channels therein. 
         FIG. 18A  illustrated a step in a method of the invention wherein a user is (i) moving the undulating actuator surface of  FIG. 17  into close proximity to targeted tissue and (ii) activating the suction source to cause aspiration through the ports. 
         FIG. 18B  illustrates a subsequent step with the suction source engaging and suctioning the targeted tissue against the undulating actuator surface together with activating the actuator to apply stimulus to the tensioned and stretched tissue. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       FIGS. 1-2  illustrate a wearable glove-like device  10  corresponding to the invention which carries a plurality of sensors  15  that can be affected or actuated by articulation of a joint in the user&#39;s hand, for example finger joints, knuckles or another joint. The wearable device  10  can have a form-fitting body  16  that is made of a thin woven stretch fabric or can be a molded elastomeric material depending on its application. In one variation, each sensor  15  can be a lyriform resistive sensor which is shown in  FIG. 2  and which can be disposed between first and second layers  18   a  and  18   b  of an elastomer to form the sensor. The sensor can be carried in the form-fitting glove body  16  to be held close to a joint. The type of sensor shown in  FIG. 2  comprises a very thin layer  22  of conductive material such as gold, platinum, copper or the like. The thin conductive layer  22  can be from about 10 nm to 50 microns in thickness. The thin conductive layer  22  is configured with a plurality of substantially parallel cuts or slits  25  which are intermediate the end portions  28   a  and  28   b  of the conductive layer  22  to which electrical leads  40  are coupled. As can be seen in  FIGS. 1 and 2 , the electrical leads  40  are connected to a battery  45  and communication unit  50 . In operation, the battery  45  and a processor control chip  55  can control electrical current flow through the sensor  15 , and stretching or flexing of the sensor will cause one of more of the slits to open and form a gap which will in turn greatly increase the resistance of the sensor, with corresponding signals registered by the processor chip  55  and communication unit  50 . Thereafter, the communication unit  50  can send signals, for example, wirelessly to a control unit  60 . The control unit  60  then can be operatively coupled to a target system  65 , which be a radio, computer, dvd player, video game, toy, robot, exoskeleton, vehicle, aircraft, watercraft, remote tool, medical instrument, or other similar target system. The thin conductive layer  22  of the lyriform sensor can be from 1 mm to 20 mm in length, 1 mm to 10 mm in width and have from 1 to 1000 slits  25  therein. The elastomer layers that house the conductive layer can be silicone, urethane or a similar elastomeric material. The device body  10  can have from 1 to 20 or more sensors  15  close to a user&#39;s finger and/or thumb joints, knuckles, wrist, etc. 
     In one variation, the wearable device  10  can be coupled to a smartphone app, wherein the smartphone app is configured simply to provide a bluetooth link to a remote system to turn said system ON/OFF. For example, the wearable device  10  could be a user&#39;s driving gloves that carried a sensor of type described above with reference to  FIGS. 2 and 3 , and actuation of the sensor could turn an automobile radio or other auto accessory ON/OFF. In another variation, the sensor and its associated microcontroller can be configured to actuate the sensor sequentially to adjust the radio volume step-wise up and down, or change stations up and down, etc. 
       FIG. 3  shows another variation of sensor  70  which is similar that of  FIG. 2  except the conductive layer  72  is a conductively doped polymer, such as a silicone doped with carbon or metallic particles. The conductive layer can be from 1 micron to 1 mm thick and also can optionally have lyriform slits therein (not shown). This sensor would operate similar to the sensor  15  of  FIG. 2  described above. In another variation, the conductive layer of a metal or polymer can be a PFOE (printed, flexible, organic electronic) sensor with a printed pattern on an elastomer substrate and be adapted to increase resistance upon stretching. 
     Now turning to  FIGS. 4  A- 4 B,  5  and  6 , a variation of a stimulus system  100  using a dove-like device with sensors graphically represented. In  FIGS. 4A-4B , the system  100  is adapted for applying stimulus to a female body and includes a form-fitting glove-like device body  104  that has a proximal body portion  105  that carries a drive unit  110  for actuating an actuatable region  115 , a distal body portion  120  that carries at least one actuatable region  115  and a medial body portion  122  that operatively couples together the proximal and distal body portions  105  and  120 .  FIG. 4A  schematically illustrates the device body  104  in perspective view and  FIG. 4B  shows the device body  104  in phantom view as worn by a human hand  124  and wrist or forearm of a first person  125 . The system is configured for applying stimulus to targeted sites of a female body which can be any types of erogenous zone or tissue, herein at times referred to a sensory tissue. Such sensory tissue can be erogenous tissue of any type A-Z, for example, as identified at http://en.wikipedia.org/wiki/Erogenous_zone. The system  100  of  FIGS. 4A, 5 and 6  is particularly adapted for stimulation of a female&#39;s Grafenberg spot, clitoris, among other sites with one objective being any type of orgasm in the female (e.g., clitoral, vaginal, squirting, etc.). 
     The system is also adapted for applying stimulus to sensory tissue that might not be commonly identified as an erogenous zone and may be individual-specific, with the objective of stimulus-induced ‘frisson’. Frisson is a sensation akin to shivering, and is typically expressed as an overwhelming emotional response combined with piloerection or goosebumps. Frisson is a short duration pleasurable sensation, in which the skin of the lower back typically flexes, and shivers rise upward and inward from the shoulders and neck and may extend to the cheeks. The face may become flush and hair follicles experience piloerection. The sensation can occur in a series of waves moving up the person&#39;s back in rapid succession. The stimulus that is needed to produce a frisson is quite specific to the individual, but as will be understood from this disclosure, a female and her partner may experiment with the stimulus system and improve communication while experiencing the stimulus. A system adapted for frisson will have systems for audible stimulus as well as visual stimulus, and allows the partners to plan in advance what audible and visual stimulus may be optimal. Often, it would be expected that musical stimulus would enhance an episode and can induce or evoke frisson, which musical stimulus can utilize the earpieces  222  and  225  (see  FIGS. 4A and 9 ) of the invention. Visual stimulus can be provided by computer screen, smartphone screen, or other light display device that may be in the background. The memory and control units of the system can harmonize and synchronize the tactile stimulus, audible stimulus, visual stimulus, and temperature stimulus, as will be described below. 
       FIG. 5  is a block diagram of components of the stimulus system  100  of an exemplary variation of the invention described herein. 
     More in particular, the variation of  FIGS. 4A-4B  has a distal body portion  120  that is adapted to be carried by first (index) and second (middle) finger,  126  and  128 , of first person  125  (or non-receiving partner as designated herein) who will use the distal body portion  120  to provide stimulus to a second person  140  (designated the receiving partner herein). In one variation, this distal body portion  120  can be fabricated of a flexible polymeric material such as silicone or a urethane. As will be described below, this distal body portion  120  carries sensors and electrical leads which can be embedded in a molded silicone or other similar flexible polymer. 
     In  FIG. 4A , the medial portion  122  of the device body  104  also can be formed or molded of a flexible polymer and typically can be molded together with the distal body portion  120 . The proximal body portion  105  is worn on the user&#39;s wrist and/or forearm and can have any type of wrap-around attachment mechanism, such as a fabric or polymeric hook and loop (e.g., Velcro) attachment  142 . This body portion  105  can be fabricated of any suitable materials such as a stretchable woven material, molded or sheet silicone, etc. As will be described below, the proximal body portion  105  carries a drive source  110  and (optionally) a control unit  145  together with other electrical components which can be disposed in an interior chamber of a silicone (or other polymer) housing of the body portion  105 . 
     Referring to  FIGS. 4A-4B , it can be seen that the distal body portion  120  is dimensioned to fit over at least one user finger, and in this variation has first and second passageways  146   a  and  146   b  to receive two user fingers. The passageways  146   a  and  146   b  can have a closed end or be open-ended, and the device body around each finger can be closely coupled to on another or separated. 
     As can be seen in  FIG. 4A , the distal body portion  120  carries at least one actuatable region  115 , and in this variation has two independent actuatable regions, with each such actuatable region  115  proximate the location of the user&#39;s fingertips in each passageway  146   a  and  146   b . By the term ‘acutatable region’, it is meant that a deformable or flexible surface  148  of the body  120  can be deflected, bulged or otherwise be pulsed outward from the body surface  148  in rapid intervals to thereby apply stimulating forces to targeted sensory tissue. In one variation shown in  FIGS. 1 and 4A-4B , the actuatable region  115  is a fluidic actuator and can comprise a fluid-tight interior chamber  150  that communicates through flow channel(s)  152  with the drive source  110 , which can be any suitable pump mechanism. This variation can be either pneumatic or hydraulic (i.e., gas or liquid actuated) with pump mechanisms described further below. 
     In the variation of  FIGS. 4A-4B , the actuatable region  115  can have a surface dimension ranging from 5 mm 2  to 20 mm 2 . In a high amplitude or high stimulus variation, the actuated region  115  can be fluid-actuated with an interior chamber  150  (see  FIG. 11D ) having a volume when expanded ranging from about 0.5 cc to 2 cc&#39;s or more. Of particular interest, the use of fluidic actuators allows for low or high amplitude pulses or displacement of the surface of body  148  and the control unit  145  allows for many variations in timing of pulse intervals as graphically represented in  FIGS. 7A-7B , further described below. In this variation, the amplitude and actuation rate can be selected from a wide range, which is not possible with vibrating devices which typically use a coin type motor. When in use, the actuatable region  115  can deform, displace and pulse the elastomeric body surface  148  upwardly from about 0.5 mm to 2 mm, which is a much larger displacement than can be provided by conventional vibrator devices, such as eccentric motor vibration mechanisms. The wall of the body in which the actuator region  115  is carried can be very thin, for example less that 2 mm, less than 1 mm and less than 0.5 mm in thickness when the interior chamber  150  is not actuated. The control unit  145  can actuate the actuatable region  115  at rates ranging from 1 Hz to 50 Hz or more. In general, the fluidic actuator can operate at a lower pulse frequency than conventional eccentric motor vibrator mechanisms or other actuator mechanisms. 
     Of particular interest, a variation of the system as shown in  FIGS. 4A, 4B, 5 and 6  includes a user-actuated communication unit  160 A that sends signals indicated at  165  to the control unit  145  to operate the device. The system  100  includes intuitive finger-actuated means for controlling device operation, which includes turning the device ON/OFF, and controlling other selected operational parameters, which typically includes the amplitude of displacement of the actuatable region  115  and pulse rate (frequency) or sequence of intervals of displacement and relaxation of the actuatable region  115  (see  FIG. 7A ). In more complex variations, other operational parameters may be modulated which include the intensity or speed of the expansion phase of the actuatable region, the speed of the relaxation phase, including acceleration and deceleration rates in these phases. The time interval of the expanded or amplified state and the relaxed state also can be controlled. In still other variations, the system may use conventional vibrating motor components to produce stimuli, and similar finger-actuated mechanisms may be used. The system may also use a combination of fluidic and vibratory elements, as will be described below. 
     In one variation shown in  FIGS. 4A, 4B, 5 and 6 , the user-actuated communication unit  160 A includes at least one stretch sensor in the distal body portion  120 , and in this variation has first and second sensors  170   a  and  170   b  that can send control signals  165  to control unit  145 . Each sensor  170   a  and  170   b  is disposed proximate a passageway  146   a  and  146   b  and is adapted to respond to stretching or bending forces caused by the user bending his or her fingers. A sensor can be a resistive stretch sensor be of the type shown in  FIGS. 2 and 3  such that when the sensor body is flexed, the resistance across the sensor increases. Other types of flex sensors are known such as the type used in a Nintendo Power Glove. Sensors are available from Robot Mesh, 11232 120th Ave. NE, Suite 201, Kirkland Wash. 98033 USA. In one embodiment, the sensors  170   a  and  170   b  provide different signals for different degrees of flexing or stretching, thus the sensors can signal the control unit  115  to increase an operating parameter, for example amplitude or pulse rate over a range, depending on the degree of flexing of a sensor. Thus in one variation, as the user increasingly bends his or her fingers, the control unit  115  will increase the pulse rate of the actuatable region  115 . In  FIG. 4A , low power electrical leads (not shown) extend from the sensors  170   a  and  170   b  to the control unit  145 . It should be appreciated that any type of sensor may be used, such as a capacitance flex sensors as is known in the art. 
     In a variation shown in  FIGS. 4A-4B , the user-actuated communication unit  160  also includes a pressure sensor  175  in the distal body portion  120  between the finger receiving passageways  146   a  and  146   b . This sensor  175  is adapted to respond to compressing forces caused by the user squeezing or tightening the space between his or her fingers to thereby compress the sensor  175 . In one embodiment, a thin film type of pressure sensor can be used and can provide different signals for different degrees of applied pressure to thereby signal the control unit to increase an operating parameter over a range, for example, an amplitude range for actuatable region  115 . A type of resistive pressure sensor is available from Tekscan, Inc., 307 West First Street, South Boston, Mass. 02127 USA. In  FIG. 1A , the low power electrical leads to pressure sensor  175  are indicated at  176 . It should be appreciated that any type of pressure sensor  175  may be used, such as a capacitance pressure sensor. It can easily be understood that a stretch sensor could be used in place of the pressure sensor, wherein the user would move his or her fingers apart to actuate the sensor. 
     Referring to  FIGS. 6 and 7A , aspects of the invention can be graphically illustrated.  FIG. 6  represents the user&#39;s fingers articulating the device&#39;s distal body portion  120  between several positions. In a variation, the system  100  also uses the sensors  170   a  and  170   b  as an ON/OFF switch and the system is not actuated when the sensors are in the straight or repose position A of  FIG. 6 . The system is switched ON when the sensors are flexed a selected degree, such as a selected degree in the range of 5° to 20°, represented as angle B in  FIG. 6  which corresponds to the ‘5 second’ mark in  FIG. 4A  when the system is actuated. Thereafter, further flexing of the sensors  170   a - 170   b  in  FIG. 6  to exemplary angles C and D sends control signals which indicate resistance, for example, and the control unit  145  increases amplitude at the corresponding ‘20 second’ mark and ‘115 second’ mark of a stimulus episode  180  as depicted  FIG. 7A . The control unit  145  compares the control signal  165  from the sensors to a look-up table of values from which a corresponding power level to operate the drive unit  115  is selected, which in turn adjusts the amplitude of the actuatable region  115  as represented in  FIG. 7A . In one variation, the person  125  wearing the device body  120  can simply articulate his or her finger and maintain the finger in a stable position and the drive unit  115  will actuate the actuatable region  115  at the predetermined amplitude and pulse rate. In other words, the non-receiving partner  125  can remain passive and the stimulation forces will be applied to the targeted site of the receiving partner. In  FIG. 7A , at the ‘210 second’ mark, the user  125  straightens his or her fingers to the angle indicated at position A in  FIG. 6  and the actuation is turned off.  FIG. 7A  simply depicts graphically hypothetical amplitudes and pulse rates of stimulus over an episode  180  or time period of stimulation, wherein a real system can have more of a continuously variable amplitude based on the continuous flexing back and forth of sensors  170   a - 170   b . In this variation, the two sensors are redundant. 
       FIG. 7A  shows the system being operated at about 2 Hz, but it should be appreciated that any baseline frequency is possible that commences upon system actuation. After understanding  FIG. 7A , it can be understood that the user  125  can contemporaneously actuate the pressure sensor  175  between the finger receiving passageways  146   a  and  146   b  (see  FIG. 4A ) to alter pulse frequency.  FIG. 7B  shows an example of user-actuated modulation of frequency wherein compression of sensor  175  increases pulse frequency. For simplicity,  FIG. 4B  indicates the compression of sensor  175  (from position X to Y) which corresponds to the change in frequency shown in  FIG. 7B  at the ‘110 second’ mark. It should be appreciated that frequency can vary over a wide range in response to a range of compression levels of sensor  175 . 
     From  FIGS. 4A, 4B, 6, 7A and 7B , it can be understood that the system can vary an operating parameter by a very intuitive movement which is the simple flexing a finger or two fingers  126  and  128 . At the same time, the fingers of the non-receiving partner  125  actually carry the actuatable regions  115  of the stimulus device—and all the while this partner  125  contemporaneously may be performing an independent digital stimulatory action at the targeted site of the receiving partner  140 . In one variation, the increased flexing of a finger at the targeted site will be in the direction of increased actuator intensity at the site, which is logical and matches what the user might do in the absence of the device. Thus, in general, the invention can be considered to provide a biorobotic assist device that can simply apply the stimulus, or in another alternative can amplify, augment or otherwise modulate the stimulatory forces that a partner  125  wearing the device might provide to the receiving partner  140 . 
       FIG. 8  indicates another adaptive aspect of the invention wherein the stimulus system  100  accommodates active movements of the user  125 , for example, the ‘come-hither’ movements of fingers by the non-receiving partner  125  during use of the stimulation system. For example, consider that the user  125  articulates his or her fingers back and forth generally as indicated  FIG. 6 , which shall be called come-hither movements herein. Such movements send signals from the sensors and communication unit  160 A to the control unit  145 . In one variation, the signals are processed by a control algorithm that monitors such a back and forth (come-hither) articulation of the fingers. If the algorithm detects rapid come-hither movements performed a pre-determined number of times in short interval, for example 2 to 10 articulations in 1 to 5 seconds, then the algorithm will recognize that the non-receiving partner  125  seeks to actively use his or her fingers to provide stimulus together with the actuator stimulus, and thereafter the control unit  145  will adjust its control of the drive unit  110  to harmonize or synchronize the actuation of the actuator region  115  with the user&#39;s (i.e., non-receiving partner  125 ) digital movements. In this aspect, the control unit  145  can modulate the pulse rate (frequency) to match the non-receiving partner&#39;s rate of finger articulation, or in another algorithm provide a pulse rate that is a multiple of the rate of finger movement. In another example, the control unit  145  can modulate the amplitude in addition to frequency, for example, to provide that a pulse will reach its peak at each moment that the user&#39;s fingers are most articulated (i.e., position D in  FIG. 6 ). In another variation, the amplitude of the actuation of the actuatable region  115  can be reduced a selected amount to harmonize with the user&#39;s digital articulation. In other words, the combination the partner&#39;s come-hither finger movements and the pulse amplitude may provide too great a stimulatory force on the target tissue, and this the control unit  145  modulates the intensity to allow the non-receiving partner  125  to be a more active participant. The control unit  145  can further provide an algorithm for detecting, when the non-receiving, partner stops  125  performing the come-hither finger movement, and thereafter the control unit  115  can take over control of the drive unit  110  to provide stimulus again based on the degree of sensor actuation for both amplitude and pulse rate. The algorithm can further provide a ‘smoothing’ code to insure there is a non-abrupt move from the ‘modulated’ operating parameters to the new operating parameters. Thus, algorithms on the control unit can insure that frequency and amplitude of stimulus are not in any way canceling the digital movements of the user, and instead are harmonized with the user&#39;s movements. This aspect of the invention will differentiate the experience for both partners from commercially available vibrator-type devices which are simply ‘on/off’ or a ‘higher/lower’ speed. 
       FIGS. 9 and 10  illustrate another interactive and adaptive aspect of the invention wherein the system  100  provides for a subtle, non-verbal interaction between the receiving partner  140  and the non-receiving partner  125  during a stimulation episode  180 . In  FIG. 9 , it can be seen that the female or receiving partner  140  wears a device  200  having a device body  210  on her hand, which in one embodiment can be a body that can fit over one or more fingers. In the variation of  FIG. 9 , the receiving party&#39;s device body  210  resembles the distal body portion  120  of the non-receiving partner&#39;s wearable device. The device body  210  of  FIG. 9  is adapted for manipulation by the receiving party  140  to ‘fine tune’ or modulate the stimulatory forces applied to her targeted sensory tissue during a stimulus episode  180  in which the intensity is initiated by her partner (i.e., the non-receiving partner  125 ). In one variation, the device body  210  has at least one stretch or flex sensor  212  that is a part of a second communication unit  160 B and transmitter  220  that is adapted to send signals to the control unit  145 . As in the non-receiving partner&#39;s device  120  (see  FIG. 4A ), the sensor  212  can send a plurality of signals via a transmitter  220  (in this case wirelessly, e.g., in Bluetooth) dependent on the degree of articulation of her fingers. In the variation of  FIG. 9 , the device body  210  carries two sensors, but they can be considered to be redundant and signals therefrom are conformed by the second communication unit  160 B and control unit  145  into a single signal  215  which is sent to the drive unit  110 . 
     The receiving partner  140 , or the partners together, can select between different modes of ‘interaction’ to operate the device  210  and thereby interact with the stimulus system  100 . More particularly, the receiving partner can select a manner in which her device body  210  can be manipulated to modulate the intensity of stimulus that has been initiated by the non-receiving partner  125 . The mechanics of mode selection is further described below. In one interaction mode, for example herein called a cooperative or ‘fine-tuning’ mode, the receiving partner&#39;s purposeful flexing of the sensor  212  (see  FIG. 9 ) signals the controller  145  to augment or reduce the intensity at which other (non-receiving) partner  125  is operating the device  120  and actuator region  115 . In this embodiment, the sensor  212  can have an intermediate ‘rest’ position or ‘no-adjust’ position indicated at R which signals the control unit  145  to make no changes in the on-going operating intensity parameters. The sensor  212  in a less articulated or straightened position R 1  can send signals to progressively reduce the on-going (and potentially changing) intensity that is set or being adjusted by the non-receiving partner  125 . The term intensity as used herein means amplitude, frequency, or the combination of amplitude and frequency. If the receiving partner  140  moves her fingers to the more articulated position R 2 , the sensor  212  sends signals  215  that will progressively increase the intensity of the stimulatory forces. This mode of operation then makes both partners&#39; inputs contemporaneously interact to ultimately control the drive unit  110 , with the receiving partner ‘fine-tuning’ the stimulatory forces which only the receiving party  140  can optimize in an immediate and non-verbal manner. In an on-going stimulus episode  180 , then both partners can continue to modulate inputs and the resulting stimulatory effects. This mode can continue until the receiving partner  140  returns the sensor  212  to its rest position R in  FIG. 9 . 
       FIG. 10  graphically depicts a hypothetical episode of interaction between the partners  125  and  140 . In  FIG. 10 , the non-receiving partner  125  actuates the system at time BB which provides a certain amplitude and frequency of stimulus using the device body as described previously. That partner  125  then at time BB and at time CC increases the amplitude of stimulation. Then, at time DD, the receiving partner  140  actuates her device  210  from the rest position R to the R 1  position (see  FIG. 9 ) which lowers and fine-tunes the amplitude to provide the desired level of stimulus. As can be seen in  FIGS. 4A, 9 and 10 , the partners wear wireless (e.g., Bluetooth) earpieces  222  and  225 , which can serve the purpose of providing a subtle, non-verbal means of informing the partners of each others actuation of system components. In this case, the receiving partner&#39;s modulation of stimulus may be accompanied by a tone in earpiece  225  of her partner  125 , which will be a cue that the receiving partner  140  wishes to fine-tune the stimulus. The tone, or sequence of intermittent tones, can be configured to indicate to the non-receiving partner  125  whether the actuation is being up- or down-modulated by the receiving partner  140 . Additional aspects or this ‘fine-tuning’ interaction mode will be described below. 
     In a second mode of interaction, the receiving partner&#39;s articulation of the body  210  and sensor  212  will displace and replace signals from the non-receiving partner&#39;s first communication unit  160 A which can be termed a ‘replacement’ mode. In selecting this mode, the receiving partner  140  in effect seeks to temporarily control the intensity of the stimulatory forces applied to the target site. The receiving party can then adjust intensity by variably flexing the sensor  212 . Again, this replacement mode can continue until the receiving partner  140  returns the sensor  212  to its rest position R in  FIG. 9 . 
     In a third mode of interaction, the receiving partner&#39;s articulation of body  210  and sensor  212  will interrupt and replace signals from the non-receiving partner&#39;s first communication unit  160 A for a time interval, for example from 2 seconds to 20 seconds or more which can be termed an ‘interruption’ mode. In selecting this mode, the receiving partner  140  wishes to influence the stimulatory forces, but also may wish to receive her partner&#39;s spontaneous or unpredictable modulation of stimulatory forces. This mode can continue until the end of a pre-selected time interval, or the mode can end when the receiving partner returns the sensor  212  to its rest position R. 
     The non-receiving partner&#39;s wearable device  210  can utilize one of several types of mode-selection mechanisms, and in one variation uses the pressure sensor  222  to signal the control unit as to which mode is selected. For example, the pressure sensor  222  can be pressed twice in a sequence comparable to a ‘double-click’ of a mouse to cycle through the options of the three modes. In effect, a selected sequence of manipulations can be adapted to select the interaction mode desired by the receiving partner  140 . A similar sensor arrangement can be provided on the receiving partners device body  210 . 
     In another aspect of the invention, referring to  FIGS. 4A, 5 and 9 , the system also includes a memory unit  240  which can record the data that reflects the modulating operating parameters that were utilized over a stimulus episode or session. In one variation, the data  250  ( FIG. 5 ) can be sent wirelessly from the control unit&#39;s processors and memory to a base memory unit  240  for storage and/or to a cloud-based memory unit indicated at  260  in  FIGS. 5 and 9 . 
     In one variation, the memory units  240  of  260  store data that reflect each episode  180 , which can be viewed in a display (i.e., phone, tablet or computer) in condensed graphic form much as depicted in  FIGS. 7A, 7B, 8 and 10  to show amplitude and frequency of stimulus during an episode. In particular, the data in a memory unit  240  or  260  can be displayed to highlight portions of an episode  180  in which the receiving party  140  modulates the input and stimulus initiated by the non-receiving party  125 . This ‘modulating’ data can then be instructional to the non-receiving party  140  for use in a future stimulus episode between the receiving and non-receiving parties  140  and  125 . This data can is useful in an aspect of the invention which is to enhance communication between the partners and thus which can contribute to enhanced female satisfaction with her partner. 
     In another variation, the control unit  145  and memory units  240 ,  260  ( FIGS. 5 and 9 ) are designed to provide feedback to the users, based on having algorithms that analyze one or more previous stimulus episodes. In one example, the control unit  145  can compare a number of previous episodes and determine if there is any common characteristics under which the receiving partner  140  intervenes to modulate the non-receiving partner&#39;s ‘leading-to’ stimulus inputs that led up to her intervention. Such ‘leading-to’ inputs can relate to stimulus intensity, interval of time following start of the episode, etc. If the control unit  145  and its algorithms find comparable interventions and stimulus modulations by the receiving partner  140 , then the control unit  145  in real time can ‘look’ for similar ‘leading-to’ inputs and if such inputs are identified, then the control unit can signal the non-receiving partner that he or she is delivering such ‘leading-to’ stimulus, which signal can be a tone in the earpiece  225 . The control unit  145  could signal the partner  140  by another means, such as a vibrator in the device, electrode stimulation, etc., for a non-receiving partner  125  that might be inattentive, distracted, tired or otherwise asleep at the wheel. A tone signal in the earpiece  225  could also have tone features that indicate an up-modulation or down-modulation is needed to match the prior data of receiving party intervention. The control unit also can notify the receiving partner  140  of the ‘leading to’ inputs by her partner, which may usefully remind her of the previous episode, inform her that the system has discovered a commonality among the previous episodes, and/or allow intentional non-intervention to permit her partner to independently modulate inputs. The system  100  thus can provide a form of subtle intervention that can unobtrusively assist both partners in optimizing stimulus in an episode. In another variation, algorithms may be developed based on group data (see below) and will function as a form of artificial intelligence to suggest stimulus options to either or both of the partners during an episode. In another variation, the users can elect to have the artificial intelligence algorithms assume control of stimulus, it the system sees a pattern for which it has a calculated response, or a partner  125  who is remote from the receiving partner  140  could use remote access to control stimulus with the receiving partner wearing and positioning the device at the targeted sensory site. 
       FIGS. 11A-11B  show schematic sectional views of the actuator region  115 , and illustrates that the polymer material on either side of the actuator chamber  150  can be very thin, for example, from about 0.02 mm to 0.5 mm which can be as thin as a condom. This is unlike other vibrator devices which do not allow for intimate contact between partners. In this variation, when the actuator region  115  is non-actuated ( FIG. 11A ), the contact between the non-receiving partner&#39;s fingers and the tissue of the targeted site will be very close, practically as if the device did not exist. In another variation, the actuator region  115  itself or the area surrounding it can be perforated to allow further tactile sensing through the membrane. In the variation that has a perforated actuator region  115 , the region would expand around each such perforation or aperture and amplitude would be lessened compared to an actuator region as shown in  FIG. 11B . 
     In another variation, referring back to  FIG. 5 , a memory unit can make the data available to a central analytic processing (CAP) system  280  which can assemble and analyze data from a plurality of episodes of different receiving parties  140  (group data). For example, the manufacturer of the system or an independent analytics group associated with system manufacturer can provide an analytic system to which users can anonymously and voluntarily send episode data. Each user can have an ID number, and the data can be accompanied by user definition of the type or objective of the episode (e.g., type A-Z as referenced above) and other relevant data. The CAP system  280  then can process that data to compare different users&#39; stimulus parameters and outcomes which can lead to potential new understandings of stimulus and response. Such data may be useful for medical and pharmacological research in fields relating to female response to stimulus as described herein where data is certainly lacking. 
     In general, a method of the invention for promoting well-being in a female comprises stimulating a first (female) person&#39;s target sensory tissue with a second person&#39;s digital movements to apply stimulus wherein the digital interface with the site includes a thin member worn by the second person and wherein the thin member includes a fluidic actuator. Further, the fluid actuator is actuated by, and actuation parameters are controlled by, the second person&#39;s digital movements. The method further comprises controlling an actuation parameter by signals from the first person and/or by signals from a control unit  145 . 
     In a method corresponding to the invention, a first person wears a stimulus device and contacts a female&#39;s targeted site with the device wherein the first person sends first control signals to a control unit to select operating parameters of a drive mechanism of the device to apply a stimulus to the site and wherein the female in response to sensations from the stimulus sends second control signals to the control unit to adjust the operating parameters. 
       FIGS. 12A-12B  illustrate another variation of stimulus system  400  that is similar to the previously described version except the system&#39;s functional parts are separable to provide re-useable and disposable components. In  FIG. 12A , a non-disposable wearable body  402  is shown which can be glove-like that again has a proximal portion  405  that carries the drive source  110 , control unit  145  and memory unit  240 . The bulk of body  402  can be a woven material that is very thin and flexible similar to a woman&#39;s nylon stockings. The body  402  has a distal portion  420  that carries at least one sensor  425  that operates as described previously. Such a sensor  170  can be positioned proximate a finger or knuckle joint, or another hand joint, to be actuated by finger or hand motion. For example, the sensor  425  can be on the outside or inside of a finger joint and is shown on the outside of the finger joint. Although two sensors are shown, a single sensor positioned on one finger is possible. While  FIG. 12A  shows a glove-like body  402 , another variation as in  FIG. 13  can simply have a proximal body portion  405  as described above with electrical leads  418  coupled to an elastomeric portion that carries sensor  425  and is configured for fitting over a finger. 
     Referring to  FIGS. 12A and 12B , it can be seen that the non-disposable wearable body  402  does not carry the actuatable region  115 . Instead,  FIG. 12B  shows a disposable body  440  that is adapted for wearing over the sensor-carrying body  402  and is configured to carry the at least one actuatable region  115 . The disposable body  440  has a proximal end  442  that has a connector  445  for coupling to the proximal body portion of the non-disposable body  402 , for example coupling pneumatic flow channels  448   a  and  448   b  to the drive unit  110  or pump mechanism in the non-disposable body  402 . In this embodiment, the disposable body  440  can be very thin, for example, 0.02 mm to 0.10 mm in thickness to allow for maximum sensitivity between the partners. In one variation, the connector  445  can couple a pneumatic line and channels  448   a  and  448   b  to an air pump. In another variation, the connector  445  can lock a sealed chamber or bladder (not shown) carried by the disposable body  440  into a receiving part of the non-disposable body  402 . The pump mechanism in this variation is a motorized component that compresses and decompresses the chamber or bladder to actuate the actuatable region  115 . 
     Referring to the variations described above, the pump systems can be of any type, for example an electromagnetic pump as known in the art and used in fluidic systems. Other types of micro- or miniature pumps can be used, such as piston pumps, diaphragm pumps, vane pumps, roller pumps, peristaltic pumps, screw pumps, impeller pumps and the like. Various micropumps and systems for use in fluidic systems are described in the following U.S. patents which are incorporated herein by reference: U.S. Pat. Nos. 8,616,227; 8,591,834; 8,590,573; 8,389,960; 8,343,442; 8,282,896; 8,206,593; 8,168,139; 8,157,434; 8,105,824; 8,104,514; 8,058,630; 8,007,746; 7,837,946; 7,695,683; 7,691,333; 7,666,361; 7,640,947; 7,476,363; 7,392,827; 7,368,163; 7,291,512; 7,118,910; 7,075,162; 7,005,493 and 6,953,058. 
     The proximal portions of the systems described above that are worn on the user&#39;s wrist carry a battery that may be replaceable or re-chargeable. In one variation, the battery can be an inductively re-chargeable battery as is known in the art. 
     In another variation, the device worn by the user can include one or more accelerometers which can send signals to the control unit and memory unit. Such accelerometer signals can detect and quantify the user&#39;s finger movements separate from the fluidic actuator&#39;s movements and such signals can be used in feedback to the user during use, for storage in the memory unit for future reference as to preferences, for providing, limits to system actuation, etc. 
       FIG. 13  illustrates a non-disposable wearable body  40 T that is a variation of the first component of a stimulus system similar to that of  FIG. 12A . In this variation, the body  40 T has a reduced form factor with a single sensor  425  that is carried on a distal portion  420 ′ adapted for fitting on a single human finger. 
       FIG. 14  is a view of another variation of a stimulus system  500  which includes an entirely disposable glove-like stimulus device  505  similar to the types illustrated in  FIG. 9  and  FIGS. 12A-12B  that includes actuatable regions  515   a ,  515   b  and  515   c  and at least one sensor  525  carried therein. The sensor  525  can be a lyriform sensor of the type shown in  FIGS. 1-2 . The actuatable region again can be fluidic chambers  105  (see  FIG. 11B ) within in a very thin elastomer wall as described previously.  FIG. 14  shows that the proximal part  542  of the device  505  includes a connection portion  545  for coupling to a wearable body  550  carrying a drive unit  110 , control unit  145  and memory unit  240  as described previously. In all other respects, the stimulus system  500  of  FIG. 14  operates as described above with the variations of  FIGS. 4A and 9 . In one variation, the connection portion  545  comprises a resilient tubular member with a sealed interior chamber that communicates with the actuators fluidic chambers  150  (see  FIG. 11B ), and the drive unit  110  can be a roller that alternatively compresses and relaxes the resilient tube to drive the actuator regions  115   a - 115   c . The sealed fluidic system can be filled with air or a liquid such as sterile water. 
     In one variation that is directed to stimulation and/or causing a frisson effect, the system can carry a liquid that can be cooled in the wearable body  550  by a cooling mechanism  570  which can be a Peltier element. In another variation, the fluidic system can provide for circulation to and from the actuator portions  540   a - 540   c  and a coolant fluid can be provided by a liquid gas cartridge or canister (e.g., a CO2 canister, argon canister or liquid nitrogen canister) that is detachably coupled to body  550  for a single use of limited use. 
       FIG. 14  is a view of another variation of a stimulus system  500  which includes an entirely disposable glove-like stimulus device  505  similar to the types illustrated in  FIG. 9  and  FIGS. 12A-12B  that includes actuatable regions  515   a ,  515   b  and  515   c  and at least one sensor  525  carried therein. The sensor  525  can be a lyriform sensor of the type shown in  FIGS. 1-2 . The actuatable region again can be fluidic chambers  150  (see  FIG. 11B ) within in a very thin elastomer wall as described previously.  FIG. 14  shows that the proximal part  542  of the device  505  includes a connection portion  545  for coupling to a wearable body  550  carrying a drive unit  110 , control unit  145  and memory unit  240  as described previously. In all other respects, the stimulus system  500  of  FIG. 14  operates as described above with the variations of  FIGS. 4A and 9 . In one variation, the connection portion  545  comprises a resilient tubular member with a sealed interior chamber that communicates with the actuators fluidic chambers  150  (see  FIG. 11  B), and the drive unit  110  can be a roller that alternatively compresses and relaxes the resilient tube to drive the actuator regions  115   a - 115   c . The sealed fluidic system can be filled with air or a liquid such as sterile water. 
     In other variations, the wearable device carrying the drive unit, control unit and/or memory unit can be worn at least in part by a body portion selected from the group of a hand, wrist, arm, leg and torso. In other variations, sensor can be configured to respond to bending, stretching, compressing, shaking, swiping, touching or a combination thereof. For example, a device worn on a torso can be useful for a system that can be operatively and detachably connected to a condom that carries one or more fluidic actuators of the types described above (cf.  FIGS. 12-12B ). 
     In another variation, an actuatable region  115  of a stimulus device of the type shown in  FIG. 4A or 12B  can have an actuatable region  115  including apertures extending through and around the expandable fluidic chamber  150  (not shown). 
     In other variations, the actuatable region  115  can optionally consist of alternative actuator mechanisms, including at least one of an eccentric rotating mass vibration mechanism, a linear resonant actuator, a piezoelectric actuator and an electro-active polymer actuator. In another variation, the actuatable region  115  can be a fluidic chamber as described above overlying one of the just-described alternative actuators (not shown). In another variation, the actuatable region  115  can be an annular fluidic chamber with one of the just-described alternative actuators surrounded by the annular fluidic chamber (not shown). 
     A method of making a stimulus device, comprising providing first and second elastomeric layers and bonding together said first and said second elastomeric layers except for a flow channel and chamber to form a monolithic elastomeric structure as can be understood from  FIGS. 12A-12B . 
     Another method of the invention can be understood from the description above and  FIGS. 4A-4B and 9 , the female or receiving partner could wear the glove-like device having the actuatable regions and position these regions in contact with her sensory tissue and then allow her partner to control the system operation remotely which may be useful for episodes in which the partners are in different locations. 
     In the system variations described above, there may be a default mode of harmonizing inputs from the users when the system is activated, with the stimulus parameters pre-selected for various degrees of actuating the sensor  170   a  and  170   b  as described with reference to  FIGS. 2-6 . In another variation, a smartphone, iPad or similar devices may be adapted to communicate with the control unit to change the operating mode, or to adjust default stimulus parameters. In general, a method of the invention comprises engaging targeted female sensory tissue with an actuatable device surface worn by a human hand, applying stimulus from the device surface to the targeted tissue and selecting operating parameters on a touchscreen of a wireless device communicating with a controller operatively connected to the actuatable device. 
       FIG. 15  schematically depicts another variation of a stimulus system  600  which again includes a glove-like stimulus device  605  similar to the type illustrated in  FIG. 9 , with the device  605  having actuatable regions  615   a  and  615   b . The actuatable regions again can be fluidic chambers  105  (see  FIGS. 11A-11B ) within in a very thin elastomer wall as described previously or can be an eccentric rotating mass vibration mechanism, a linear resonant actuator, a piezoelectric actuator or an electro-active polymer actuator. The proximal part  620  of the device  605  again carries, or is coupled to, a drive unit  110  for driving the actuator regions  615   a  and  615   b , a control unit  145  and a memory unit  240  as described above. In this variation, the control unit  145  is adapted to receive signals  622  (e.g., bluetooth signals) from a music source  625  such as a smartphone, radio or computer that sends the music signals  622 . 
     In response to the music signals, the system  600  can apply stimulus from the actuator regions to the targeted tissue with the stimulus parameters being controlled and modulated by the control unit  145  in response to an ‘aspect’ of the music, or in response to multiple aspects of the music. The ‘aspects’ of the music that may be used by a controller algorithm to modulate stimulus parameters can be pitch, beat, rhythm, tempo, loudness and/or timbre. In one variation, the stimulus parameters that can be modulated in response to music are frequency and/or amplitude of motion of the actuator region as described previously. In another variation, the amplitude of suction through a surface of the actuator region (and the resultant tissue stabilization and/or stretching) can be modulated in response to the music signal  622 . An additional system variation is shown below in  FIGS. 16A-16C, 17, 18A and 18B  that provides subsystems for incorporating suction ports into an actuator surface. 
       FIG. 15  schematically depicts another variation of a stimulus system  600  which again includes a glove-like stimulus device  605  similar to the type illustrated in  FIG. 9 , with the device  605  having actuatable regions  615   a  and  615   b . The actuatable regions again can be fluidic chambers  150  (see  FIGS. 11A-11B ) within in a very thin elastomer wall as described previously or can be an eccentric rotating mass vibration mechanism, a linear resonant actuator, a piezoelectric actuator or an electro-active polymer actuator. The proximal part  620  of the device  605  again carries, or is coupled to, a drive unit  110  for driving the actuator regions  615   a  and  615   b , a control unit  145  and a memory unit  240  as described above. In this variation, the control unit  145  is adapted to receive signals  622  (e.g., bluetooth signals) from a music source  625  such as a smartphone, radio or computer that sends the music signals  622 . 
     Now referring to  FIGS. 16A-18B , another system variation  650  is shown that includes suction functionality integrated into a surface layer of an actuator region. More in particular,  FIG. 16A  shows a wearable device  655  that is similar to previous embodiments with this variation having a single actuatable region  660  but it should be appreciated that multiple actuatable regions are possible as in previous embodiments. The proximal part  664  of the device  650  again includes or is connected to a drive unit  110  for actuating the actuator region  660 , a control unit  145  and a memory unit  240  as in previous variations. In this variation, the proximal part  664  of the device  650  also carries a motor driven pump or vacuum source  670  that communicates with a flow channel  672  in the wearable device  655  that extends to the actuator region  660 .  FIG. 16B  is a sectional view of one variation of an actuator region  660  which has a channeled or undulating surface  675  that is shown in a greatly enlarged cut-away view in  FIG. 17 . As can be seen in  FIG. 17 , the undulating surface  675  has aspiration ports  680  in the troughs  682  of the actuator surface. Each of the ports  680  communicates with an interior flow channel branch  672   a - 672   c  that extends back to the flow channel  672  and to the suction source  670 . The undulations can have a height ranging from about 0.5 mm to 5.0 mm with a similar range from peak to peak of the undulations. 
     In the variation of actuator shown in  FIGS. 16A and 17 , it can be seen that at least one mechanical actuator or vibration mechanism  690  is carried inward of the undulating surface  675  and inward of the flow channel branches  672   a - 672   c  and ports  680 . The actuator is a linear resonant actuator, an eccentric rotating mass vibration mechanism, or a piezoelectric actuator. It also would be possible to have a fluidic actuator as described above disposed in a layer below the flow channel branches  672   a - 672   c  and ports  680 .  FIG. 16C  illustrates another similar actuator region  660 ′ that has two actuators or vibrating mechanisms  690 ′ that have different orientations relative to one another, which again can be a linear resonant actuator, an eccentric rotating mass vibration mechanism, or a piezoelectric actuator. Multiple actuators that apply stimulus in different vectors is believed to be useful for the stimulation of targeted tissue from different angles which can synchronized to be in unison or can be sequential. The periphery of the undulating surface  675  can be planar as in  FIG. 16A , convex as in  FIG. 16B  or concave depending on the device and targeted tissue, and in general, the targeted soft tissue can conform to shape of the undulating surface  675 . 
       FIGS. 18A and 18B  are greatly enlarged sectional views of the undulating surface  675  of a stimulus device in use and illustrate a method of engaging the targeted tissue.  FIG. 18A  shows the undulating surface  675  in close proximity to a target tissue surface. In this variation, the undulating surface  675  has an inner layer  692  of an elastomeric material and surface layer  695  of a very low modulus elastomer that can conform to any tissue surface. In various embodiments, the surface layer  695  can be fluid impermeable and hydrophilic.  FIG. 18A  shows the suction source  670  being actuated with aspiration forces indicated by arrows  696 . 
       FIG. 18B  shows the undulating surface  675  moved into contact with the targeted tissue and the suction forces indicated by arrows  696  pulling the tissue surface into the undulations. This has the effect stabilizing the tissue to better receive the stimulation forces indicated at  700  from the actuator  690 . Further, the tissue surface will be somewhat stretched and tensioned in the direction of arrows  702  in  FIG. 18B  which can make receptors in the targeted tissue more receptive to stimulation. Further, the suction forces applied to the targeted tissue can increase blood flow to the engaged tissue which can be important in a stimulation episode. In general, a method of stimulus for promoting female well-being comprises engaging a targeted surface of female sensory tissue with a device worn on a human hand to thereby stretch or tension the targeted surface, and applying stimulus from the device surface to said tensioned tissue surface to stimulate sensory tissue. The method includes applying suction to the targeted tissue surface through a plurality of flow passageways and ports distributed over the device surface. The method further includes applying the stimulation forces in unison or sequentially from different actuators along different vectors. Further, the stimulation forces can be modulated by the subject and her partner interactively as described in previous embodiments. 
     In another variation, the actuator surface  675  as in  FIGS. 16A-18B  can be fabricated with a second set of flow pathways and ports for providing fluid inflows to the targeted tissue from a fluid reservoir  710  in the wearable device  655  (see  FIG. 15 ). A fluid for delivery through the system can be a lubricating fluid, a cooled fluid, a heated fluid, an aromatic fluid, a hydrating fluid, a therapeutic fluid or a pharmacologic fluid. 
     A number of embodiments of the invention have been described. Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the invention.