Abstract:
Next generation sequencing technologies are becoming a preferred method for sequencing nucleic acids and profiling miRNAs. Experimental results disclosed herein show that the most common platform for preparing nucleic acids such as miRNAs for sequencing introduces serious biases. Provided herein are compositions and methods for improved sequencing and miRNA profiling using a set of customized ligation adaptors.

Description:
RELATED APPLICATIONS 
     The present application claims priority to U.S. Provisional Application No. 61/519,023, filed May 13, 2011, the disclosure of which is incorporated by reference herein in its entirety, including drawings. 
    
    
     TABLE SUBMITTED ON COMPACT DISK 
     Table 2 is contained on a CD-R provided herewith under the file name “54435.8095.US02 Table 2.txt.” This file is 194 kb and was created on May 11, 2012. The machine format is IBM-PC and the operating system compatibility is MS-Windows. Two copies of the CD-R containing Table 2 are provided pursuant to 37 C.F.R. §1.52(e)(iii). The complete contents of the CD-R are hereby incorporated by reference herein. Any reference to Table 2 in the specification represents an incorporation by reference of the contents of the file 54435.8095.US02 Table 2.txt at that particular location in the specification.  
     
       
         
               
             
           
               
                 LENGTHY TABLES 
               
             
             
               
                 The patent contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&amp;DocID=US08859239B2). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3). 
               
             
          
         
       
     
     SEQUENCE LISTING SUBMITTED ON COMPACT DISK 
     The sequence listing in computer readable format is contained on a CD-R provided herewith under the file name “Sequence Listing.txt.” This file is 15 kb and was created on May 11, 2012. The machine format is IBM-PC and the operating system compatibility is MS-Windows. Two copies of the CD-R containing the sequence listing in computer readable format are provided pursuant to 37 C.F.R. §1.824. The complete contents of the CD-R are hereby incorporated by reference herein. A paper copy of the sequence listing is also provided. 
     BACKGROUND 
     Small RNAs (smRNAs) encompass several different classes of non-coding RNAs, including microRNAs (miRNAs), short interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), and small nuclear RNAs (snRNAs). Among the endogenous smRNAs, miRNA is the most well studied with regard to both biogenesis and functional mechanism. miRNAs are short RNA molecules that act as post-transcriptional regulators by binding to mRNA and preventing it from being translated. The first miRNA, Lin-4, was identified in  C. elegans  in 1993 (Lee 1993; Wightman 1993). In 2000, a second miRNA, Let-7, was identified and found to be conserved across many species (Pasquinelli 2000; Reinhart 2000). In 2001, it was disclosed that miRNAs probably exist in all species (Lee 2001; Lau 2001; Lagos-Quintana 2001). Since 2001, miRNA research has extended to almost all corners of biological science, with in-depth investigations into miRNA biogenesis and biological functions and the use of miRNA as a therapeutic tool, diagnosis and prognosis marker, and treatment response predictor marker (Galasso 2010; Nagpal 2010; Kim 2009; Bartel 2009). This progression in miRNA study has coincided with the identification and profiling of novel smRNAs in many organisms. 
     smRNA profiling have traditionally relied on cloning and sequencing of individual RNAs using standard molecular methods. In the most common approach, adaptor oligonucleotides are joined to the 3′ and 5′ termini of smRNAs, and the ligation products are reverse transcribed and PCR amplified to generate a cDNA library. This procedure represents a significant technical challenge because it requires three gel purification steps. In addition, thousands of clones have to be individually sequenced to identify the smRNA population. This standard protocol is labor intensive, painstaking, and requires large amounts of starting materials, and therefore is not practical for many research or clinical settings (Pfeffer 2005). Although cost can be reduced several fold by concatenating fragments of smRNAs with both adaptors to sequence several clones together, expense is still a major obstacle in thoroughly surveying smRNA populations. 
     Next generation sequencing (NGS) technology was first applied to smRNA discovery with the use of massive parallel signature sequencing to survey the smRNA library of  Arabidopsis thaliana  (Lu 2005). Since then, many modified smRNA profiling procedures based on NGS have been developed and tested on various platforms (Hafner 2008; Lu 2007; Tang 2010). To date, human miRNAs alone represent 1,048 unique sequence entries in miRBase 16 (Griffiths-Jones 2010). NGS technology has also helped in the discovery of other smRNAs (Lu 2005). 
     Illumina&#39;s NGS technology (Solexa) has been rated one of the two leading protocols for RNA sequencing (Levin 2010). The Solexa platform has gained some advantage over other smRNA profiling protocols with their smRNA cloning protocol v1.5. This protocol, which is summarized in  FIG. 1 , drastically reduces the difficulties of smRNA cDNA library construction by eliminating the need for gel purification of smRNA/smRNA-adaptors (the most challenging and critical steps in smRNA discovery) and by requiring only about 1 μg of total RNA. However, it has been found that this protocol presents a major artifact in smRNA sequencing experiments. Therefore, there is a need in the art for improved methods of smRNA sequencing. 
     SUMMARY 
     Provided herein in certain embodiments are isolated polynucleotides comprising, consisting of, or consisting essentially of a nucleotide sequence selected from the group consisting of SEQ ID NOs:2 to 65. 
     Provided herein in certain embodiments are compositions comprising one or more isolated polynucleotides each independently comprising, consisting of, or consisting essentially of a nucleotide sequence selected from the group consisting of SEQ ID NOs:2 to 65. In certain of these embodiments, the composition comprises a specific set of two or more isolated polynucleotides each independently comprising, consisting of, or consisting essentially of a nucleotide sequence selected from the group consisting of SEQ ID NOs:2 to 65, and in certain of these embodiments the set is selected from a) a set of polynucleotides representing each of SEQ ID NOs:2-9, b) a set of polynucleotides representing each of SEQ ID NOs:10-17, c) a set of polynucleotides representing each of SEQ ID NOs:18-25, d) a set of polynucleotides representing each of SEQ ID NOs:26-33, e) a set of polynucleotides representing each of SEQ ID NOs:34-41, f) a set of polynucleotides representing each of SEQ ID NOs:42-49, g) a set of polynucleotides representing each of SEQ ID NOs:50-57, h) a set of polynucleotides representing each of SEQ ID NOs:58-65, i) a set of polynucleotides representing each of SEQ ID NOs:2-9 and 50-57, j) a set of polynucleotides representing each of SEQ ID NOs:10-17 and 58-65, k) a set of polynucleotides representing each of SEQ ID NOs:18-25 and 34-41, l) a set of polynucleotides representing each of SEQ ID NOs:26-33 and 42-49, m) a set of polynucleotides representing each of SEQ ID NOs:2-9, 18-25, 34-41, and 50-57, n) a set of polynucleotides representing each of SEQ ID NOs:10-17, 26-33, 42-49, 58-65; and o) a set of polynucleotides representing each of SEQ ID NOs:2-65. 
     Provided herein in certain embodiments are methods of preparing a target nucleic acid for sequencing comprising the steps of: a) ligating a 3′ adaptor to the target nucleic acid, wherein the 3′ adaptor consists of the nucleotide sequence of SEQ ID NO:66 or is an extended 3′ adaptor comprising the nucleotide sequence of SEQ ID NO:66 with one or more nucleotides added to the 5′ end; b) ligating a 5′ adaptor to the 3′ adaptor-target nucleic acid complex of step (a), wherein the 5′ adaptor consists of the nucleotide sequence of SEQ ID NO:1 or is an extended 5′ adaptor comprising the nucleotide sequence of SEQ ID NO:1 with one or more nucleotides added to the 3′ end; c) reverse transcribing the 3′ adaptor-target nucleic acid-5′ adaptor ligation product of step (b); d) PCR amplifying the reverse transcribed ligation product of step (c); and e) gel purifying the amplified target nucleic acid; provided that at least one of steps (a) and (b) must utilize an extended 3′ or 5′ adaptor, respectively. In certain of these embodiments, the target nucleic acid is a DNA or RNA molecule, and in certain of these embodiments the target nucleic acid is a smRNA. In certain embodiments, the methods further comprise a step of sequencing the gel purified target nucleic acid of step (e). In certain embodiments, the extended 5′ adaptor comprises a nucleotide sequence selected from the group consisting of SEQ ID NOs:2 to 65. In certain embodiments, more than one 3′ adaptor and/or more than one 5′ adaptor is used for steps (a) and (b), respectively. In certain of these embodiments, step (b) utilizes a pool of 5′ adaptors each independently comprising, consisting of, or consisting essentially of the nucleotide sequences of SEQ ID NOs:2 to 65. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1 : Diagram of Illumina v1.5 smRNA preparation and sequencing protocol. 
         FIG. 2 : Heatmap of clustered normalized reads of miRNA population for 64 customized 5′ adaptors. Total reads of each adaptor were normalized to a constant and each miRNA was scaled up according to the ratio of constant to the total reads. Normalized reads were Log2 transformed and the value was used to cluster miRNAs as complete linkage and generate the heatmap. 
         FIG. 3 : ACGU distribution of the first three bases in all human miRNAs documented in miRBase 15. 
         FIG. 4 : miRNA expression variation as measured using designed 8×8 adaptor pools (P1 to P8) and randomized adaptor pools (R1 to R8). 
         FIG. 5 : Pearson correlation of designed 8×8 adaptor pools (P1 to P8) versus randomized adaptor pools (R1 to R8). 
         FIG. 6 : Heatmap from Test 2. Lanes 2 and 6, duplicate run of 8&#39;8 pools; Lane 3, 16×4 pools; Lane 4, 32×2 pools; Lane 5: 64×1 pool. Total reads of miRNAs in different lanes were normalized and log2 transformed to generate the heatmap. 
         FIG. 7 : Normalized, log2 transformed miRNA read counts from Lane 2 (X-axis) and Lane 6 (Y-axis) of Test 2. 
         FIG. 8 : Pearson correlation among adaptor pools in Test 2. Variation between adaptor pools was greatly reduced in the 16×4 pools (P17, P28, P35, and P46) versus the 8×8 pools (P1 to P8). 
         FIG. 9 : A. Reproducibility among eight adaptor pools. Normalized, log2 transformed miRNA read counts from Lane 7 of Test 2 using breast RNA were plotted by adaptor pools. B. Heatmap of breast RNA eight adaptor pooling results. 
         FIG. 10 : Reproducibility among 16, 32, and 64 adaptor pools. Normalized, log2 transformed miRNA read counts from Test 2 using breast RNA were plotted by adaptor pools. 
         FIG. 11 : Northern blot analysis of miR-21, -1, -126, -205, and -101 in human RNA pool and human breast RNA. U6 snRNA was used as RNA loading control. Lane 0: RNA decade marker; Lane 1: human RNA pool; Lane 2: breast RNA. 
         FIG. 12 : Heatmaps of 8×8 pools versus 16×4 pools versus 32×2 pools in Test 1. These results indicate that index pooling reduced miRNA expression variation. 
         FIG. 13 : Re-analyzed data of Test 1. Data was reorganized by 16×4 adaptor pools. These results indicate that miRNA expression between designed pools shows less variation. 
         FIG. 14 : Re-analyzed data of Test 1. Data was reorganized by 32×2 adaptor pools. These results indicate that miRNA expression between pools shows even less variation. 
     
    
    
     DETAILED DESCRIPTION 
     The following description of the invention is merely intended to illustrate various embodiments of the invention. As such, the specific modifications discussed are not to be construed as limitations on the scope of the invention. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of the invention, and it is understood that such equivalent embodiments are to be included herein. 
     Illumina&#39;s v1.5 smRNA preparation protocol (“Illumina protocol”) utilizes five main steps: 1) ligation of the 3′ adaptor to smRNA, 2) ligation of the 5′ adaptor to smRNA, 3) reverse transcription of smRNA with both adaptors to cDNA, 4) PCR amplification of the cDNA, and 5) smRNA gel purification. The default 3′ adaptor, which is modified to target smRNAs with a 3′ hydroxyl group, corresponds to the surface-bound amplification primer and is required for reverse transcription. The default 5′ adaptor, which has the nucleotide sequence set forth in SEQ ID NO:1, is required for amplification of smRNA fragments. 
     smRNA libraries prepared by the Illumina protocol are loaded onto single-read flowcells for cluster generation. During this process, the smRNA samples are bound to complementary adaptor oligonucleotides grafted onto the surface of an Illumina Genome Analyzer flow cell. These complementary adaptor oligonucleotides bind to either the 5′ or 3′ adaptors. Unlabeled nucleotides are added to initiate a solid-phase bridge amplification, which results in the formation of double-stranded bridges. The double-stranded molecules are denatured to generate single-stranded templates anchored to the substrate, followed by amplification to generate dense clusters of double-stranded DNA. Sequencing by synthesis (SBS) is then performed to ascertain the sequences of the smRNAs. 
     One drawback of the Illumina protocol is that the bridge amplification step requires both the 5′ and 3′ adaptors to be complementary to the complementary adaptor oligonucleotides on the flowcell surface. This creates a problem using bases within the sequences of either adaptor for barcoding. 
     Due to heterogeneity of the 3′ends of smRNAs, the fact that SBS is more likely to generate errors close to the end of the short reads (Wu 2007; Tian 2010), and the fact that the Illumina protocol specifically requires the pre-adenylated 5′ end of the 3′ adaptor (which is expensive to make), the 3′ end of the 5′ adaptor is the choice for multiplexing in the same flowcell for sequencing smRNAs of about 17 to 32 nts in length, such as piRNA, tRNA halves, and snoRNA derived smRNAs (Riedmann 2010; Thomson 2009; Pederson 2010; Ender 2008; Taft 2009). 
     As disclosed herein, the Illumina protocol was modified by adding three nucleotides (nt) at the 3′ end of the default 5′ adaptor for multiplexing. 64 different three nt sequences were utilized, representing all possible three nt combinations. The resultant customized 5′ adaptors were compared to the default Illumina 5′ adaptor for their efficacy in identifying miRNAs from various tissue samples using the Illumina protocol. Significant read biases were observed for each of the adaptor sequences. This kind of bias in smRNA digital gene expression profiling has been reported previously (Linsen 2009). To overcome these biases, the customized 5′ adaptors were combined into eight pools of eight adaptors each, four pools of 16 adaptors each, two pools of 32 adaptors each, and one pool of 64 adaptors. Pooling was based on the cluster data for the 64 customized 5′ adaptors. The last three nts of the customized 5′ adaptors were all found to influence the sequencing results ( FIG. 2 ). Analysis of the pool data showed that pools containing 16, 32, or 64 customized 5′ adaptors minimized results bias, and were sufficient to identify all highly expressed miRNAs in various tissue samples ( FIGS. 4 ,  5 , and  12 - 14 ). Most importantly, subsequent comparison of miRNA sequencing of the same miRNA sample showed that the pooled customized 5′ adaptors dramatically reduced result bias as compared to the default 5′ adaptor. Use of all pools (8, 16, 32, and 64) resulted in a significant improvement in miRNA population coverage versus the use of the default adaptor alone, and resulted in identification of 893 of the 1,100 human mature miRNA/miRNA* sequences (about 81%) documented in miRBase 15. To further verify the superiority of the pooled adaptors to the default Illumina 5′ adaptor, the eight adaptor pools and the default Illumina 5′ adaptor were used to sequence miRNA from human breast tissue. The eight adaptor pools produced results that were more consistent with Northern blotting results than those obtained using the default adaptor ( FIG. 11 ). 
     In summary, the results disclosed herein reveal a significant pitfall in the use of the default 5′ adaptor in the Illumina protocol. Sequence results obtained using this adaptor are biased by the short nucleotide fragments being sequenced, and therefore may not reflect the true biological composition of a sequence sample. Coverage and abundance are crucial to the evaluation of miRNA biological function and to the utilization of miRNAs as biomarkers in a clinical setting. 
     The compositions and methods disclosed herein can be used to overcome various shortcomings associated with Illumina and other next generation sequencing technologies that utilize adaptor sequences ligated to a sequence of interest, and to provide improved sequencing results for target nucleic acids. These target nucleic acids may be DNA or RNA molecules, including for example smRNA molecules. In certain embodiments, the target nucleic acids may be part of a target nucleic acid sample containing two or more target nucleic acids. In these embodiments, the target nucleic acid sample may comprise two or more copies of a single target nucleic acid, or it may comprise one or more copies of two or more different target nucleic acids. For example, a target nucleic acid sample may comprise one or more RNA molecules, DNA molecules, or a mixture thereof (such as a genomic nucleic acid sample). 
     Provided herein in certain embodiments are isolated polynucleotides for use in identifying, tagging, and sequencing a target nucleic acid. The target nucleic acid may be a DNA molecule or an RNA molecule, and in certain embodiments the target nucleic acid may be a smRNA molecule. In certain embodiments, the isolated polynucleotides consist of or consist essentially of the nucleotide sequence of the default Illumina 5′ adaptor (SEQ ID NO:1) with one or more nucleotides added to the 3′ end. In certain of these embodiments, the isolated polynucleotides consist of or consist essentially of the nucleotide sequence of SEQ ID NO:1 plus one, two, three, four, five, six, seven, eight, or more than eight nucleotides added to the 3′ end. In certain of these embodiments, the isolated polynucleotides comprise, consist of, or consist essentially of a nucleotide sequence as set forth in any of SEQ ID NOs:2-65. 
     Provided herein in certain embodiments are isolated polynucleotides for use in identifying, tagging, and sequencing a target nucleic acid. The target nucleic acid may be a DNA molecule or an RNA molecule, and in certain embodiments the target nucleic acid may be a smRNA molecule. In certain embodiments, the isolated polynucleotides consist of or consist essentially of the nucleotide sequence of the default Illumina 3′ adaptor (SEQ ID NO:66) with one or more nucleotides added to the 5′ end. In certain of these embodiments, the isolated polynucleotides consist of or consist essentially of the nucleotide sequence of SEQ ID NO:66 plus one, two, three, four, five, or more than five nucleotides added to the 5′ end. 
     Provided herein in certain embodiments are compositions comprising one or more of the isolated polynucleotides provided herein. In certain embodiments, these compositions comprise four or more, eight or more, 16 or more, 24 or more, 32 or more, 40 or more, 48 or more, 56 or more, or 64 or more of the isolated polynucleotides provided herein. In certain embodiments, the compositions comprise isolated polynucleotides comprising, consisting of, or consisting essentially of each of the nucleotide sequences of 1) SEQ ID NOs:2-9; 2) SEQ ID NOs:10-17; 3) SEQ ID NOs:18-25; 4) SEQ ID NOs:26-33; 5) SEQ ID NOs:34-41; 6) SEQ ID NOs:42-49; 7) SEQ ID NOs:50-57; 8) SEQ ID NOs:58-65; 9) SEQ ID NOs:2-9 and 50-57; 10) SEQ ID NOs:10-17 and 58-65; 11) SEQ ID NOs:18-25 and 34-41; 12) SEQ ID NOs:26-33 and 42-49; 13) SEQ ID NOs:2-9, 18-25, 34-41, and 50-57; 14) SEQ ID NOs:10-17, 26-33, 42-49, 58-65; and 15) SEQ ID NOs:2-65. In certain embodiments, these kits further comprise instructions for use. 
     Provided herein in certain embodiments is the use of one or more of the isolated polynucleotides or compositions provided herein for the identification, tagging, sequencing, and/or preparation for sequencing of one or more target nucleic acids. The target nucleic acids may be DNA molecules or RNA molecules, and in certain embodiments the target nucleic acids may be smRNA molecules. 
     Provided herein in certain embodiments are kits comprising one or more of the polynucleotides provided herein. In certain embodiments, these kits comprise four or more, eight or more, 16 or more, 24 or more, 32 or more, 40 or more, 48 or more, 56 or more, or all 64 of the isolated polynucleotides provided herein. In certain embodiments, the kits comprise isolated polynucleotides comprising, consisting of, or consisting essentially of each of the nucleotide sequences of 1) SEQ ID NOs:2-9; 2) SEQ ID NOs:10-17; 3) SEQ ID NOs:18-25; 4) SEQ ID NOs:26-33; 5) SEQ ID NOs:34-41; 6) SEQ ID NOs:42-49; 7) SEQ ID NOs:50-57; 8) SEQ ID NOs:58-65; 9) SEQ ID NOs:2-9 and 50-57; 10) SEQ ID NOs:10-17 and 58-65; 11) SEQ ID NOs:18-25 and 34-41; 12) SEQ ID NOs:26-33 and 42-49; 13) SEQ ID NOs:2-9, 18-25, 34-41, and 50-57; 14) SEQ ID NOs:10-17, 26-33, 42-49, 58-65; and 15) SEQ ID NOs:2-65. In certain embodiments, these kits further comprise instructions for use. 
     Provided herein in certain embodiments are methods for improving the Illumina protocol by using one or more of the isolated polynucleotides provided herein in place of the default Illumina 5′ adaptor of SEQ ID NO:1 and/or the default Illumina 3′ adaptor of SEQ ID NO:66. In certain embodiments, more than one of the isolated polynucleotides provided herein are utilized such that a pool of 5′ or 3′ adaptors is present in the RNA adaptor ligation mixture. In certain of these embodiments, the 5′ and/or 3′ adaptor pool comprises eight or more, 16 or more, 24 or more, 32 or more, 40 or more, 48 or more, 56 or more, or 64 or more of the isolated polynucleotides provided herein. In certain of these embodiments, the 5′ adaptor pool comprises a combination of isolated polynucleotides comprises, consisting of, or consisting essentially of each of the nucleotide sequences of 1) SEQ ID NOs:2-9; 2) SEQ ID NOs:10-17; 3) SEQ ID NOs:18-25; 4) SEQ ID NOs:26-33; 5) SEQ ID NOs:34-41; 6) SEQ ID NOs:42-49; 7) SEQ ID NOs:50-57; 8) SEQ ID NOs:58-65; 9) SEQ ID NOs:2-9 and 50-57; 10) SEQ ID NOs:10-17 and 58-65; 11) SEQ ID NOs:18-25 and 34-41; 12) SEQ ID NOs:26-33 and 42-49; 13) SEQ ID NOs:2-9, 18-25, 34-41, and 50-57; 14) SEQ ID NOs:10-17, 26-33, 42-49, 58-65; and 15) SEQ ID NOs:2-65. 
     Provided herein in certain embodiments are methods for preparing a target nucleic acid for sequencing comprising the steps of 1) ligating a 3′ adaptor to the target nucleic acid; 2) ligating a 5′ adaptor to the 3′ adaptor-target nucleic acid complex; 3) reverse transcribing the 3′ adaptor-target nucleic acid-5′ adaptor ligation product, 4) PCR amplifying the reverse transcribed ligation product to amplify target nucleic acids bound to adaptor molecules on both ends; and 5) gel purifying the amplified target nucleic acid, wherein one or both of the 3′ and 5′ adaptors are isolated polynucleotides as provided herein. In certain embodiments, the target nucleic acid is a smRNA molecule. In these embodiments, the methods comprise the steps of 1) ligating a 3′ adaptor to the smRNA; 2) ligating a 5′ adaptor to the 3′ adaptor-smRNA complex; 3) reverse transcribing the 3′ adaptor-smRNA-5′ adaptor ligation product, 4) PCR amplifying the reverse transcribed ligation product to amplify smRNAs bound to adaptor molecules on both ends; and 5) gel purifying the amplified smRNA, wherein one or both of the 3′ and 5′ adaptors are isolated polynucleotides as provided herein. As one example, in certain embodiments the 5′ adaptor comprises the nucleotide sequence of SEQ ID NO:1 with one or more nucleotides added to the 3′ end, and/or the 3′ adaptor comprises the nucleotide sequence of SEQ ID NO:66 with one or more nucleotides added to the 5′ end. In certain embodiments, a pool of more than one 5′ or 3′ adaptor is utilized for the ligation step. For example, the ligation step may utilize a pool of adaptors comprising eight or more, 16 or more, 24 or more, 32 or more, 40 or more, 48 or more, 56 or more, or 64 or more of the isolated polynucleotides provided herein. In certain embodiments, the methods of target nucleic acid preparation disclosed herein further comprise the step of actually sequencing the target nucleic acid, for example using Illumina NGS technology. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the target nucleic acid is smRNA, the primary method steps are carried out according to the Illumina v1.5 smRNA preparation protocol, with the only difference being the substitution or supplementation of the Illumina default 5′ and/or 3′ adaptors with one or more of the isolated polynucleotides provided herein. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the target nucleic acid is smRNA, the 3′ ligation adaptor ligation step is carried out as follows. The 3′ ligation adaptor(s) is diluted in nuclease free water and mixed with the smRNA sample, and this mixture is incubated at 70° C. for two minutes. The mixture is placed on ice, then mixed with T4 RNL2 truncated reaction buffer (NEB), MgCl 2 , truncated T4 RNA ligase 2 (NEB), and RNase inhibitor and incubated at 22° C. for one hour. In certain embodiments, one or more oligonucleotides complementary to all or part of the 3′ ligation adaptor(s) are included in the ligation reaction mixture. In these embodiments, the oligonucleotides hybridize to the 3′ adaptors to prevent hybridization of the adaptors to smRNA. In certain of these embodiments, the oligonucleotide may be tagged to facilitate oligonucleotide removal following completion of the 3′ ligation adaptor ligation step. Suitable tags include, for example, magnetic beads or biotin. In certain embodiments, the oligonucleotides may comprise all or a portion of the sequence of the default Illumina PCR primers set forth in SEQ ID NOs:67 and 68. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the target nucleic acid is smRNA, the 5′ ligation adaptor ligation step is carried out as follows. The 5′ ligation adaptor(s) is pre-heated to 70° C. for two minutes, transferred to ice, and then added to the 3′ ligation mixture of the previous paragraph along with ATP and T4 RNA ligase. This mixture is incubated at 20° C. for one hour. In certain embodiments, one or more oligonucleotides complementary to all or part of the 5′ ligation adaptor(s) are included in the ligation reaction mixture. In these embodiments, the oligonucleotides hybridize to the 5′ adaptors to prevent hybridization of the adaptors to smRNA. In certain of these embodiments, the oligonucleotide may be tagged to facilitate oligonucleotide removal following completion of the 5′ ligation adaptor ligation step. Suitable tags include, for example, magnetic beads or biotin. In certain embodiments, the oligonucleotides may comprise all or a portion of the sequence of the default Illumina PCR primers set forth in SEQ ID NOs:67 and 68. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the nucleic acid is smRNA, the reverse transcription step is carried out as follows. The ligated smRNA sample is mixed with SRA RT primer (Illumina), centrifuged briefly, heated at 70° C. for two minutes, then placed on ice. First strand buffer (Invitrogen), dNTP mix, DTT, and RNase inhibitor are mixed together, then added to the primer-annealed ligated smRNA sample and heated at 48° C. for three minutes. SuperScript II Reverse Transcriptase (Invitrogen) is added to the mixture, followed by incubation at 44° C. for one hour. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the target nucleic acid is smRNA, the post-reverse transcription PCR amplification step is carried out as follows. Water, Phusion HF buffer (Illumina), primer GX1 (Illumina), primer GX2 (Illumina), dNTP mix, and Phusion DNA polymerase (Illumina) are mixed together, and the reverse transcribed smRNA sample is added to this mixture. PCR amplification is then performed using one 30 second cycle at 98° C., twelve cycles of 10 second at 98° C., 30 seconds at 60° C., and 15 seconds at 72° C., and a ten minute cycle at 72° C., followed by holding the sample at 4° C. In certain embodiments, the number of cycles may be adjusted up or down based on the amount of smRNA in the initial sample. 
     In certain embodiments of the target nucleic acid preparation methods provided herein wherein the target nucleic acid is smRNA, the target smRNA may undergo one or more additional steps before, during, or after the primary method steps. For example, the target smRNA may undergo one or more isolation, purification, and/or concentrating steps prior to the 3′ adaptor ligation step. Similarly, the target smRNA may undergo one or more amplification steps prior to the 3′ adaptor ligation step. In certain embodiments, the integrity of the target smRNA molecule may be evaluated before, during, or after any of the primary method steps. 
     A target nucleic acid for use in the methods disclosed herein may be obtained from any biological sample containing nucleic acids such as DNA, RNA, smRNA, or combinations thereof. The biological sample may be obtained from any species, including a mammalian species such as a human. In certain embodiments, the target nucleic acid sample is obtained from a bodily fluid such as blood or saliva. In other embodiments, the target nucleic acid sample is obtained from a solid tissue sample, including for example a biopsy sample. In certain embodiments wherein the target nucleic acid is an smRNA molecule, the smRNA molecule may be in a sample comprising more than 1 μg of total RNA, and in certain of these embodiments the smRNA sample comprises more than 2 μg, more than 4 μg, more than 6 μg, more than 8 μg, or more than 10 μg of total RNA. In certain embodiments, the smRNA sample comprises 1-10 μg of total RNA. 
     Provided herein in certain embodiments are methods of diagnosing a disease using the target nucleic acid preparation and sequencing methods provided herein. In these embodiments, nucleic acid samples from a subject are prepared and sequenced using the methods disclosed herein, then compared to one or more reference sequences representing nucleic acid sequences associated with a particular disease. For example, where the nucleic acid samples contain smRNA, the reference sequences may include bacterial or viral smRNA sequences. In these embodiments, identification of a nucleic acid sequence matching one of the reference sequences indicates the presence of a particular disease, including for example a bacterial or viral infection. 
     The term “comprising” as used herein, particularly with regard to a component of a composition or a step of a method, encompasses compositions and methods consisting of or consisting essentially of the component or step. 
     The following examples are provided to better illustrate the claimed invention and are not to be interpreted as limiting the scope of the invention. To the extent that specific materials are mentioned, it is merely for purposes of illustration and is not intended to limit the invention. One skilled in the art may develop equivalent means or reactants without the exercise of inventive capacity and without departing from the scope of the invention. 
     EXAMPLES 
     Example 1 
     Evaluation of Three Nucleotide 5′ Adaptor Extensions 
     It has been reported previously that it is possible to add several nts to the 5′ adaptor tail for barcoding for miRNA profiling (Witten 2010; Cronn 2008). To evaluate the effect of three nt extensions, 64 different extension sequences (Table 1) were added to the 3′ end of the default Illumina 5′ adaptor (SEQ ID NO:1) to produce a series of 64 customized 5′ adaptors. 
     
       
         
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                 Three nucleotide extensions 
               
               
                 (SEQ ID NO: of resulting customized 5′ adaptor) 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 AAA 
                 AAU 
                 AAC 
                 AAG 
                 GAA 
                 GAU 
                 GAC 
                 GAG 
               
               
                 (2) 
                 (10) 
                 (18) 
                 (26) 
                 (34) 
                 (42) 
                 (50) 
                 (58) 
               
               
                 UAU 
                 UAC 
                 UAG 
                 UAA 
                 AGU 
                 AGC 
                 AGG 
                 AGA 
               
               
                 (3) 
                 (11) 
                 (19) 
                 (27) 
                 (35) 
                 (43) 
                 (51) 
                 (59) 
               
               
                 AUC 
                 AUG 
                 AUA 
                 AUU 
                 ACC 
                 ACG 
                 ACA 
                 ACU 
               
               
                 (4) 
                 (12) 
                 (20) 
                 (28) 
                 (36) 
                 (44) 
                 (52) 
                 (60) 
               
               
                 UUG 
                 UUA 
                 UUU 
                 UUC 
                 UCG 
                 UCA 
                 UCU 
                 UCC 
               
               
                 (5) 
                 (13) 
                 (21) 
                 (29) 
                 (37) 
                 (45) 
                 (53) 
                 (61) 
               
               
                 GCA 
                 GCU 
                 GCC 
                 GCG 
                 GUA 
                 GUU 
                 GUC 
                 GUG 
               
               
                 (6) 
                 (14) 
                 (22) 
                 (30) 
                 (38) 
                 (46) 
                 (54) 
                 (62) 
               
               
                 CCU 
                 CCC 
                 CCG 
                 CCA 
                 CUU 
                 CUC 
                 CUG 
                 CUA 
               
               
                 (7) 
                 (15) 
                 (23) 
                 (31) 
                 (39) 
                 (47) 
                 (55) 
                 (63) 
               
               
                 CGC 
                 CGG 
                 CGA 
                 CGU 
                 CAC 
                 CAG 
                 CAA 
                 CAU 
               
               
                 (8) 
                 (16) 
                 (24) 
                 (32) 
                 (40) 
                 (48) 
                 (56) 
                 (64) 
               
               
                 GGG 
                 GGA 
                 GGU 
                 GGC 
                 UGG 
                 UGA 
                 UGU 
                 UGC 
               
               
                 (9) 
                 (17) 
                 (25) 
                 (33) 
                 (41) 
                 (49) 
                 (57) 
                 (65) 
               
               
                   
               
             
          
         
       
     
     For Test 1, the 64 customized 5′ adaptors were individually ligated with smRNA-3′adaptor molecules and smRNA libraries from eight adaptors pooled together for cluster generation and SBS. smRNA preparation was carried out using the Illumina manufacturer&#39;s protocols (Preparing Samples for Small RNA Sequencing Using the Alternative v1.5 Protocol, Small RNA sample prep Kit# FC-102-1009, Illumina Inc.) with minor optimization. Equal amounts of 20 human tissue RNAs from Ambion human total RNA survey panel (AM6000) were mixed as human total RNA pool in order to balance smRNA population and mimic the abundance and 3′ and 5′ heterogeneity of smRNA sequences. RNA in the pool was derived from adipose, bladder, brain, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testes, thymus, thyroid, and trachea tissue. The RNA pool was used for smRNA library construction, cluster generation, and SBS. 1.0 μg of pooled total RNA was ligated to the default Illumina 3′ adaptor (SEQ ID NO:66) with T4 RNA ligase 2 and truncated (New England BioLabs) at 22 ° C. for 1 hour; The 3′ adaptor-miRNA ligation was then ligated to the default Illumina 5′ adapter, one of the 64 customized 5′ adaptors, or an 8, 16, 32, or 64 adaptor pool of customized 5′ adaptors (0.5 μl of 5 μM per reaction) with T4 RNA ligase I (New England BioLabs) at 20° C. for 1 hour. The resultant smRNA library was reverse transcribed using GX1 (SEQ ID NO:67) as RT primer, then subjected to PCR amplification for 12 cycles using the primers GX1 and GX2 (SEQ ID NO:68). Amplified smRNAs were gel purified using a 6% TBE PAGE gel with size selection (for targeted smRNA of 17-32 nt). The purified library was quantified using qPCR with the forward primer of SEQ ID NO:69 and the reverse primer of SEQ ID NO:70, and the quantified denatured miRNA library was loaded in 1 ml hybridization buffer to a final DNA concentration of 8 pM and used for single read flow cell cluster generation. 42 cycle (42 nt) sequencing was performed using Illumina Genome Analyzer II (GAII). 
     Raw reads from Test 1 shown in Table 2 (set forth in the file “54435.8095.US00.txt” submitted herewith on CD-R), and the test results are summarized in Table 3. Total reads for each adaptor were normalized to a constant, and each miRNA was scaled up according to the ratio of constant to the total reads. Log2 transformed normalized reads were clustered and used to generate a heatmap ( FIG. 2 ). Serious result biases were introduced by both the customized 5′ adaptors and the default 5′ adaptor. There were biases in the number of total reads, percentage of reads that were aligned to corresponding genomes, distribution of smRNAs to different categories, coverage of different species in the same smRNA population, and abundance of individual smRNAs. Read counts for some individual miRNAs were different by as much as 200-fold. 
     To eliminate the possibility that the smRNA reads processing software might be producing the bias, reads were profiled using different miRNA profiling software systems implemented with different data analysis algorithms. Reads from the 8-pool adaptors from lane 1 of Test 1 were profiled using miRExpress and Novoalign. 
     For Novoalign data processing, image analysis and base calling analysis were performed using the Illumina Genome Analysis Package (OLB v1.6 and CASAVA v1.6). The base calling analysis did not apply the Illumina default chastity filter, which discards about 30 to 40% of the reads with low quality from the first 25 bases being sequenced and generated 42-nt long reads in FASTQ format. Quality control of the reads was done during alignment by Novoalign software that filters out low quality reads by base quality score. Comparison studies showed that this Novoalign filters performed similarly to the Illumina default chastity filter. Reads were separated using Novobarcode software (http://www.novocraft.com), and aligned to human genome hg18 (NCBI build 36.1) using Novoalign software (http://www. novocraft.com) with default settings but for the following modifications: an aligned read requires a minimum of 16 nts in length with good base quality after 3′ adapter trimming and a perfect match to the reference genome. A mapping table was created using the human miRNA mature sequences from miRBase 15 and aligned back to the hg18 genome afterwards. If a read was able to be aligned to multiple loci, it was randomly assigned to one locus. To summarize the expression levels of smRNAs, reads of a smRNA falling into the mapped smRNA regions within five base extensions were treated as valid reads and counted. If a smRNA could be mapped to multiple genome loci, the counts at each locus were summed as the total number of reads for that smRNA. 
     For statistical analysis of the miRNA expression levels, total count of miRNAs in each barcoded sample was scaled to a constant (1.7 million) and log2 transformed with an offset of one. MiRNAs with normalized reads over 6 in at least 10% of the samples were kept for subsequent expression correlation efficiency analysis. Hierarchical clustering with one-Pearson correlation as distance measurement and complete linkage was conducted with Cluster 3.0 and viewed in Java TreeView (de Hoon 2004; Saldanha 2004). 
     miRExpress software analyzed miRNAs by matching reads directly to pre-miRNA or mature miRNAs sequences (Wang 2009). The default setting was used to count reads that could perfectly match to pre-miRNAs. 
     Although the rank of miRNAs by read counts in miRExpress and Novoalign was not identical, read counts and abundance rank were comparable between the two programs (Table 4). These results establish that the data analysis algorithm is not a major cause for the sequencing bias. 
     Table 5 compares the results for the top 20 miRNAs with both the default 5′ adaptor and the customized 5′ adaptors. These results suggest that the default 5′ adaptor is incapable of sequencing certain miRNAs (e.g., miR-1, -145, -215, -126 and -451), but favors others (e.g., miR-20a, -17, -155, -1246 and -146a). 
     
       
         
               
               
             
               
               
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 Sorted by 
                   
               
               
                 default 5′ adaptor 
                 Sorted by average 
               
             
          
           
               
                   
                 Pool- 
                   
                 of adaptors pool 
               
             
          
           
               
                 miRNA 
                 avg 
                 Default 
                 miRNA 
                 Pool-avg 
                 Default 
               
               
                   
               
             
          
           
               
                 hsa-miR-21 
                 339251 
                 1852326 
                 hsa-miR-143 
                 1984995 
                 17640 
               
               
                 hsa-miR-378 
                 178769 
                 1201524 
                 hsa-miR-1 
                 429851 
                 39 
               
               
                 hsa-let-7f 
                 211659 
                 510653 
                 hsa-miR-21 
                 339251 
                 1852326 
               
               
                 hsa-miR-30e 
                 50344 
                 238220 
                 hsa-let-7a 
                 221170 
                 182815 
               
               
                 hsa-miR-30d 
                 68551 
                 235117 
                 hsa-let-7f 
                 211659 
                 510653 
               
               
                 hsa-miR-101 
                 57845 
                 194516 
                 hsa-miR-378 
                 178769 
                 1201524 
               
               
                 hsa-let-7a 
                 221170 
                 182815 
                 hsa-miR-126 
                 169586 
                 2 
               
               
                 hsa-miR- 
                 69620 
                 169524 
                 hsa-miR-30a 
                 140659 
                 425 
               
               
                 142-3p 
               
               
                 hsa-miR- 
                 77003 
                 167654 
                 hsa-miR-26a 
                 137699 
                 23823 
               
               
                 148a 
               
               
                 hsa-miR-20a 
                 9939 
                 138720 
                 hsa-miR-24 
                 123388 
                 1815 
               
               
                 hsa-miR-155 
                 3910 
                 118345 
                 hsa-miR- 
                 77003 
                 167654 
               
               
                   
                   
                   
                 148a 
               
               
                 hsa-miR-103 
                 23391 
                 97269 
                 hsa-miR-192 
                 71314 
                 12660 
               
               
                 hsa-miR-17 
                 8244 
                 75571 
                 hsa-miR- 
                 69620 
                 169524 
               
               
                   
                   
                   
                 142-3p 
               
               
                 hsa-let-7g 
                 47101 
                 72910 
                 hsa-miR-30d 
                 68551 
                 235117 
               
               
                 hsa-miR- 
                 38710 
                 67006 
                 hsa-miR- 
                 67342 
                 51686 
               
               
                 140-3p 
                   
                   
                 146b-5p 
               
               
                 hsa-miR- 
                 67342 
                 51686 
                 hsa-miR-145 
                 67237 
                 40 
               
               
                 146b-5p 
               
               
                 hsa-miR-191 
                 22303 
                 49626 
                 hsa-miR-29a 
                 65488 
                 40124 
               
               
                 hsa-miR- 
                 6148 
                 49235 
                 hsa-miR-101 
                 57845 
                 194516 
               
               
                 1246 
               
               
                 hsa-miR- 
                 8939 
                 45680 
                 hsa-miR-215 
                 57179 
                 142 
               
               
                 146a 
               
               
                 hsa-miR-29a 
                 65488 
                 40124 
                 hsa-miR-451 
                 56674 
                 5 
               
               
                   
               
             
          
         
       
     
     Neither the distribution of the first three nts in the human miRNAs ( FIG. 3 ) nor the secondary structures and thermal dynamic properties of the 64 adaptors (Table 3, columns 2, 3, and 9) were found to have a reasonable correlation with the result bias. Interestingly, the clustered Test 1 results revealed that all three added nts influenced the results. This clustering result was roughly divided into eight groups ( FIG. 2 ). Based on these eight groups, the 64 customized adaptors were organized into eight designed pools of eight adaptors each (P1-P8) with balanced bases at each position. These 8×8 pools were merged to form four pools of 16 adaptors each (P17, P28, P35, and P46), the 16×4 pools were merged to form two pools of 32 adaptors each (P1357 and P2468), and the two 32×2 pools were merged to form a single pool of 64 adaptors (Pall). The pooling strategy is summarized in Table 6. 
     
       
         
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
             
               
               
               
             
               
               
             
           
               
                 TABLE 6 
               
               
                   
               
             
             
               
                   
                 P1 
                 P2 
                 P3 
                 P4 
                 P5 
                 P6 
                 P7 
                 P8 
               
               
                   
               
               
                  8 × 8 
                 AAA 
                 AAU 
                 AAC 
                 AAG 
                 GAA 
                 GAU 
                 GAC 
                 GAG 
               
               
                 pools 
                 UAU 
                 UAC 
                 UAG 
                 UAA 
                 AGU 
                 AGC 
                 AGG 
                 AGA 
               
               
                   
                 AUC 
                 AUG 
                 AUA 
                 AUU 
                 ACC 
                 ACG 
                 ACA 
                 ACU 
               
               
                   
                 UUG 
                 UUA 
                 UUU 
                 UUC 
                 UCG 
                 UCA 
                 UCU 
                 UCC 
               
               
                   
                 GCA 
                 GCU 
                 GCC 
                 GCG 
                 GUA 
                 GUU 
                 GUC 
                 GUG 
               
               
                   
                 CCU 
                 CCC 
                 CCG 
                 CCA 
                 CUU 
                 CUC 
                 CUG 
                 CUA 
               
               
                   
                 CGC 
                 CGG 
                 CGA 
                 CGU 
                 CAC 
                 CAG 
                 CAA 
                 CAU 
               
               
                   
                 GGG 
                 GGA 
                 GGU 
                 GGC 
                 UGG 
                 UGA 
                 UGU 
                 UGC 
               
               
                   
               
             
          
           
               
                   
                 P17 
                 P28 
                 P35 
                 P46 
               
               
                   
               
               
                 16 × 4 
                 P1 
                 P2 
                 P3 
                 P4 
               
               
                 pools 
                 P7 
                 P8 
                 P5 
                 P6 
               
               
                   
               
             
          
           
               
                   
                 P1357 
                 P2468 
               
               
                   
               
               
                 32 × 2 
                 P17 
                 P28 
               
               
                 pools 
                 P35 
                 P46 
               
               
                   
               
             
          
           
               
                   
                 Pall 
               
               
                   
               
               
                 64 × 1 
                 P1357 
               
               
                 pool 
                 P2468 
               
               
                   
               
             
          
         
       
     
     Correlation efficiency showed that the designed pools of 8 adaptors provided significantly more compact results than randomized pools of 8 adaptors, with the designed pools showing less miRNA expression variation than the randomized pools ( FIGS. 4 and 5 ). Pooled results from Test 1 indicate that index pooling reduced miRNA expression variation, with larger index pools resulting in less miRNA expression bias among same size pools ( FIG. 12-14 ). 
     For Test 2, the designed adaptor pools were used for 5′ adaptor ligation to smRNA-3′adaptors. This approach allowed for the use of one group of 8, 16, 32, or 64 adaptors to barcode one sample. Consistent results were observed across all the adaptor pools ( FIGS. 6 and 7 , Table 7) The use of pools containing 16 adaptors was sufficient to minimize results bias ( FIGS. 8-10 ), and miRNA expression measurement between the 16, 32, and 64 adaptor pools showed about 99% correlation ( FIG. 6 ). Correlation efficiency using the 16 adaptor pool to run four samples per flowcell versus running one sample was about 0.99. Only about 10% of miRNAs were undetectable in the four sample run compared to the one sample run (Table 8). The 10% missed were typically less abundant miRNAs. Therefore, the use of 16 adaptor pools to barcode four samples per flowcell is sufficient to identify all highly expressed miRNAs with an expression measurement that is comparable to that obtained with one sample per lane. 
     
       
         
               
               
               
               
               
               
               
             
           
               
                 TABLE 8 
               
               
                   
               
               
                 16 × 4 
                   
                   
                 P17 in 
                 P28 in 
                 P35 in 
                 P46 in 
               
               
                 pool 
                 miRBase 
                 All in lane 
                 Lane 4- 
                 Lane 4- 
                 Lane 4- 
                 Lane 4- 
               
               
                 results 
                 15 
                 4-Test 2 
                 Test 2 
                 Test 2 
                 Test 2 
                 Test 2 
               
               
                   
               
             
             
               
                 Unique 
                 1100 
                 763 
                 666 
                 664 
                 678 
                 663 
               
               
                 miRNAs 
               
               
                   
               
             
          
         
       
     
     Comparison of Test 2 data showed the profiling coverage of miRNAs increased by almost 100% using the pooled adaptors versus the default 5′ adaptor (Table 9). 
     
       
         
               
               
               
               
               
               
               
             
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                   
                 Default 
                 64 × 1 
                 32 × 2 
                 16 × 4 
                 8 × 8 pool 
                 8 × 8 pool 
               
               
                   
                 adaptor 
                 pool 
                 pool 
                 pool 
                 (Lane 2) 
                 (Lane 6) 
               
             
          
           
               
                 Raw read 
                 miRNA coverage measured by unique miRNA sequences 
               
               
                 counts 
                 (1100 in miRBase 15) 
               
               
                   
               
             
          
           
               
                 ≧1 
                 461 
                 776 
                 760 
                 763 
                 774 
                 769 
               
               
                 ≧5 
                 348 
                 636 
                 643 
                 627 
                 625 
                 645 
               
               
                 ≧10 
                 297 
                 573 
                 583 
                 573 
                 575 
                 579 
               
               
                 ≧100 
                 189 
                 379 
                 383 
                 364 
                 373 
                 382 
               
               
                 ≧1000 
                  93 
                 184 
                 184 
                 171 
                 174 
                 179 
               
               
                   
               
             
          
         
       
     
     Reads from all runs in both Test 1 and Test 2 showed that 893 miRNAs were detected (Table 10). This represents about 81% of the 1,100 human mature miRNA/miRNA* sequences documented in miRBase 15. 
     
       
         
               
               
               
             
               
               
               
             
           
               
                 TABLE 10 
               
               
                   
               
               
                   
                 miRNA coverage measured 
                   
               
               
                   
                 by unique miRNA sequences 
               
               
                 miRNA raw read counts 
                 (Test 1 + Test 2) 
                 By % 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 ≧1 
                 893 
                 81.18 
               
               
                 ≧5 
                 821 
                 74.64 
               
               
                 ≧10 
                 776 
                 70.55 
               
               
                 ≧100 
                 603 
                 54.82 
               
               
                 ≧1000 
                 407 
                 37.00 
               
               
                   
               
             
          
         
       
     
     The low coverage and bias of the Illumina default adaptor may play a role in detecting low abundance miRNA and miRNA*. The miRNA* family are classified as low abundance strands from the same precursor miRNA. However, in the experiments disclosed herein, the abundance was reversed for 21 pairs of miRNA/miRNA*, with 28 miRNAs detected at less than 10 times the abundance of their corresponding miRNA* (Table 11). 
     To validate the pooling strategy, breast tissue total RNA (#AM6952, Table 7) and human pooled total RNA was sequenced using the eight adaptor pools or the default Illumina 5′ adaptor. The results showed consistent performance among the eight adaptor pools ( FIG. 9 ). The relative abundance of miR-21, -1, -126, -101, and -205 in breast RNA and pooled human tissue RNA as measured by normalized read counts is set forth in Table 12. The eight adaptor pools were effective at identifying all five miRNAs in both tissue samples, while the default adaptor over-reported two (miR-21 and miR-101) and was largely ineffective at identifying the other three (miR-1, miR-126, and mi-R205). 
     
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 12 
               
               
                   
               
               
                 RNA source 
                 Human RNA pool 
                 Human RNA pool 
                 Breast RNA 
               
               
                 5′ Adaptor 
                 Default 
                 8 × 8 pool 
                 8 × 8 pool 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 hsa-miR-21 
                 1911436 
                 368479 
                 488594 
               
               
                 hsa-miR-1 
                 40 
                 450370 
                 2909 
               
               
                 hsa-miR-126 
                 2 
                 175101 
                 222838 
               
               
                 hsa-miR-101 
                 200723 
                 61050 
                 77431 
               
               
                 hsa-miR-205 
                 0 
                 5408 
                 90397 
               
               
                   
               
             
          
         
       
     
     Next, expression levels of miR-21, -1, -126, -101, and -205 in breast RNA versus pooled human tissue RNA were evaluated by Northern blot as previously described (Sun 2009). 20 μg of human pooled total RNA or breast total RNA were loaded onto a 12% PAGE/8M urea gel. Northern blot results were consistent with the eight adaptor pool sequencing results from both breast RNA and pooled human RNA ( FIG. 11 ). However, the Northern blot results were not consistent with the default adaptor sequencing results from pooled RNA tissue. These results further verify the superiority of miRNA tagging and sequencing using the pooled adaptors versus the default Illumina adaptor. 
     As stated above, the foregoing are merely intended to illustrate the various embodiments of the present invention. As such, the specific modifications discussed above are not to be construed as limitations on the scope of the invention. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of the invention, and it is understood that such equivalent embodiments are to be included herein. All references cited herein are incorporated by reference as if fully set forth herein. 
     REFERENCES 
     1. Bartel, Cell 136:215 (2009) 
     2. Chiang et al., Genes Dev 24:992 (2010) 
     3. Cronn et al., Nucl Acids Res 36:e122 (2008) 
     4. Cummins et al., Proc Natl Acad Sci USA 103:3687 (2006) 
     5. de Hoon et al., Bioinformatics 20:1453 (2004) 
     6. Ender et al., Mol Cell 32:519 (2008) 
     7. Galasso et al., Genome Med 2:12 (2010) 
     8. Goff et al., PLoS One 4:e7192 (2009) 
     9. Griffiths-Jones, Curr Protoc Bioinformatics Chapter 12, Unit 12.9.1 (2010) 
     10. Hafner et al., Methods 44:3 (2008) 
     11. Kim et al., Nat Rev Mol Cell Biol 10:126 (2009) 
     12. Lagos-Quintana et al., Science 294:853 (2001) 
     13. Lau et al., Science 294:858 (2001) 
     14. Lee et al., Cell 75:843 (1993) 
     15. Lee et al., Science 294:862 (2001) 
     16. Levin et al., Nat Methods 7:709 (2010) 
     17. Linsen et al., Nat Methods 6:474 (2009) 
     18. Lu et al., Science 309:1567 (2005) 
     19. Lu et al., Methods 43:110 (2007) 
     20. Nagpal et al., Curr Mol Med 10:503 (2010) 
     21. Pasquinelli et al., Nature 408:86 (2000) 
     22. Pederson, RNA 16:1865 (2010) 
     23. Pfeffer et al., Curr Protoc Mol Biol Chapter 26, Unit 26.4 (2005) 
     24. Reinhart et al., Nature 403:901 (2000) 
     25. Riedmann &amp; Schwentner, RNA Biol 7:133 (2010) 
     26. Saldanha, Bioinformatics 20:3246 (2004) 
     27. Sun et al., RNA 15:1640 (2009) 
     28. Taft et al., RNA 15:1233 (2009) 
     29. Tang et al., Nat Protoc 5:516 (2010) 
     30. Thomson &amp; Lin, Annu Rev Cell Dev Biol 25:355 (2009) 
     31. Tian et al., BMC Bioteclmol 10:64 (2010) 
     32. Wang et al., BMC Bioinformatics 10:328 (2009) 
     33. Wightman et al., Cell 75:855 (1993) 
     34. Witten et al., BMC Biol 8:58 (2010) 
     35. Wu et al., PLoS One 2:e1020 (2007) 
     
       
         
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                 Correlation 
                 Count of 
               
               
                   
                 # of 
                   
                   
                   
                   
                   
                 of miRNA 
                 miRNAs 
               
               
                   
                 secondary 
                   
                   
                   
                   
                   
                 with 
                 with same 
               
               
                   
                 structures 
                   
                   
                   
                   
                   
                 average # of 
                 1st three 
               
               
                   
                 predicted 
                   
                   
                   
                 # of reads that 
                   
                 miRNA in 
                 nts as the 
               
               
                 Last 3 nts 
                 by 
                 # of G and 
                   
                 # of reads that 
                 can be aligned 
                 % of reads 
                 all adaptors 
                 last 3 nts of 
               
               
                 of custom 
                 QuikFold 
                 C nts in 
                 # of total 
                 passed filter of 
                 to human 
                 that passed 
                 (linear 
                 the custom 
               
               
                 adaptor 
                 3.0 
                 adaptor 
                 reads 
                 Novoalignment 
                 genome 18 
                 filter 
                 scale) 
                 adaptor 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 AAA 
                 5 
                 0 
                 2,873,823 
                 2,602,433 
                 1,854,870 
                 71.3% 
                 0.9836 
                 47 
               
               
                 AAU 
                 5 
                 0 
                 2,363,426 
                 2,174,865 
                 1,577,744 
                 72.5% 
                 0.9852 
                 19 
               
               
                 AAC 
                 5 
                 1 
                 2,443,514 
                 2,221,513 
                 1,584,608 
                 71.3% 
                 0.9846 
                 20 
               
               
                 AAG 
                 5 
                 1 
                 2,294,143 
                 1,650,306 
                 1,072,384 
                 65.0% 
                 0.9848 
                 21 
               
               
                 ACA 
                 5 
                 1 
                 2,659,638 
                 2,466,420 
                 2,065,694 
                 83.8% 
                 0.9716 
                 11 
               
               
                 ACU 
                 5 
                 1 
                 1,865,696 
                 1,748,929 
                 1,422,241 
                 81.3% 
                 0.9691 
                 31 
               
               
                 ACC 
                 5 
                 2 
                 2,427,509 
                 2,022,047 
                 1,489,387 
                 73.7% 
                 0.9844 
                 12 
               
               
                 ACG 
                 5 
                 2 
                 2,141,983 
                 1,596,426 
                 1,264,670 
                 79.2% 
                 0.9899 
                 5 
               
               
                 AUA 
                 5 
                 0 
                 2,943,442 
                 2,767,906 
                 2,086,642 
                 75.4% 
                 0.9886 
                 12 
               
               
                 AUU 
                 5 
                 0 
                 1,819,682 
                 1,715,885 
                 1,324,440 
                 77.2% 
                 0.9810 
                 8 
               
               
                 AUC 
                 5 
                 1 
                 2,280,279 
                 2,150,454 
                 1,464,065 
                 68.1% 
                 0.9663 
                 21 
               
               
                 AUG 
                 5 
                 1 
                 2,005,752 
                 1,663,633 
                 1,226,855 
                 73.7% 
                 0.9853 
                 14 
               
               
                 AGA 
                 7 
                 1 
                 1,866,123 
                 1,496,581 
                 1,092,992 
                 73.0% 
                 0.9891 
                 23 
               
               
                 AGC 
                 5 
                 2 
                 4,100,291 
                 2,246,985 
                 1,615,537 
                 71.9% 
                 0.9845 
                 15 
               
               
                 AGU 
                 6 
                 1 
                 2,266,066 
                 2,096,199 
                 1,493,172 
                 71.2% 
                 0.9894 
                 13 
               
               
                 AGG 
                 3 
                 2 
                 2,186,275 
                 482,034 
                 319,862 
                 66.4% 
                 0.9905 
                 38 
               
               
                 UAA 
                 1 
                 0 
                 2,186,275 
                 482,034 
                 319,862 
                 77.8% 
                 0.9855 
                 32 
               
               
                 UAU 
                 1 
                 0 
                 3,689,221 
                 3,421,227 
                 2,703,636 
                 79.0% 
                 0.9853 
                 19 
               
               
                 UAC 
                 1 
                 1 
                 3,075,174 
                 2,744,694 
                 2,193,399 
                 79.9% 
                 0.8707 
                 17 
               
               
                 UAG 
                 1 
                 1 
                 3,090,672 
                 2,617,560 
                 1,817,026 
                 69.4% 
                 0.9793 
                 28 
               
               
                 UCA 
                 1 
                 1 
                 2,830,564 
                 2,587,389 
                 1,998,448 
                 77.2% 
                 0.5842 
                 24 
               
               
                 UCU 
                 1 
                 1 
                 1,900,004 
                 1,577,456 
                 1,148,322 
                 72.8% 
                 0.3917 
                 24 
               
               
                 UCC 
                 1 
                 2 
                 1,733,729 
                 1,531,841 
                 1,131,036 
                 73.8% 
                 0.5377 
                 24 
               
               
                 UCG 
                 1 
                 2 
                 3,255,088 
                 2,672,867 
                 1,860,778 
                 69.6% 
                 0.3742 
                 12 
               
               
                 UUA 
                 3 
                 0 
                 2,064,236 
                 1,908,719 
                 1,541,108 
                 80.7% 
                 0.6899 
                 13 
               
               
                 UUU 
                 3 
                 0 
                 2,869,685 
                 2,596,616 
                 2,071,204 
                 79.8% 
                 0.7896 
                 19 
               
               
                 UUC 
                 3 
                 1 
                 2,415,109 
                 2,267,877 
                 1,768,381 
                 78.0% 
                 0.9945 
                 25 
               
               
                 UUG 
                 3 
                 1 
                 2,367,315 
                 2,098,963 
                 1,685,140 
                 80.3% 
                 0.6990 
                 17 
               
               
                 UGA 
                 1 
                 1 
                 615,726 
                 506,892 
                 366,514 
                 72.3% 
                 0.9819 
                 38 
               
               
                 UGC 
                 1 
                 2 
                 2,500,231 
                 2,034,397 
                 1,530,145 
                 75.2% 
                 0.9846 
                 21 
               
               
                 UGU 
                 2 
                 1 
                 2,778,109 
                 2,528,513 
                 1,826,787 
                 72.2% 
                 0.6044 
                 31 
               
               
                 UGG 
                 2 
                 2 
                 2,295,023 
                 1,279,694 
                 897,849 
                 70.2% 
                 0.9784 
                 43 
               
               
                 CAA 
                 7 
                 1 
                 2,085,449 
                 1,950,978 
                 1,443,135 
                 74.0% 
                 0.9846 
                 36 
               
               
                 CAU 
                 7 
                 1 
                 2,577,649 
                 2,446,969 
                 1,844,074 
                 75.4% 
                 0.9865 
                 14 
               
               
                 CAC 
                 7 
                 2 
                 2,154,266 
                 1,979,033 
                 1,505,862 
                 76.1% 
                 0.9886 
                 15 
               
               
                 CAG 
                 7 
                 2 
                 2,980,868 
                 2,160,044 
                 1,528,713 
                 70.8% 
                 0.9818 
                 24 
               
               
                 CCA 
                 7 
                 2 
                 1,947,457 
                 1,750,754 
                 1,376,395 
                 78.6% 
                 0.9865 
                 16 
               
               
                 CCU 
                 7 
                 2 
                 1,877,313 
                 1,701,980 
                 1,260,847 
                 74.1% 
                 0.9864 
                 19 
               
               
                 CCC 
                 7 
                 3 
                 1,765,335 
                 1,417,864 
                 989,471 
                 69.8% 
                 0.9830 
                 13 
               
               
                 CCG 
                 9 
                 3 
                 1,579,577 
                 1,307,675 
                 1,032,027 
                 78.9% 
                 0.9909 
                 4 
               
               
                 CUA 
                 7 
                 1 
                 1,846,184 
                 1,721,094 
                 1,294,698 
                 75.2% 
                 0.9280 
                 14 
               
               
                 CUU 
                 7 
                 1 
                 2,883,730 
                 2,695,491 
                 2,070,122 
                 76.8% 
                 0.9830 
                 14 
               
               
                 CUC 
                 8 
                 2 
                 2,912,793 
                 2,526,398 
                 1,849,228 
                 73.2% 
                 0.9913 
                 27 
               
               
                 CUG 
                 9 
                 2 
                 3,648,901 
                 3,127,550 
                 2,478,456 
                 79.2% 
                 0.8337 
                 34 
               
               
                 CGA 
                 3 
                 2 
                 3,174,936 
                 2,740,749 
                 1,975,732 
                 72.1% 
                 0.9906 
                 3 
               
               
                 CGC 
                 8 
                 3 
                 3,233,287 
                 2,237,951 
                 1,629,380 
                 72.8% 
                 0.9894 
                 5 
               
               
                 CGU 
                 8 
                 2 
                 3,043,880 
                 2,731,024 
                 2,038,981 
                 74.7% 
                 0.9942 
                 5 
               
               
                 CGG 
                 1 
                 3 
                 3,543,206 
                 659,906 
                 461,155 
                 69.9% 
                 0.9502 
                 12 
               
               
                 GAA 
                 4 
                 1 
                 4,601,179 
                 4,100,429 
                 2,849,364 
                 69.5% 
                 0.9879 
                 15 
               
               
                 GAU 
                 3 
                 1 
                 4,017,562 
                 3,718,452 
                 2,681,945 
                 72.1% 
                 0.9914 
                 5 
               
               
                 GAC 
                 4 
                 2 
                 3,865,704 
                 3,282,978 
                 2,272,584 
                 69.2% 
                 0.9910 
                 5 
               
               
                 GAG 
                 3 
                 2 
                 4,079,254 
                 2,397,622 
                 1,564,181 
                 65.2% 
                 0.9872 
                 9 
               
               
                 GCA 
                 7 
                 2 
                 3,348,917 
                 2,892,130 
                 2,310,215 
                 79.9% 
                 0.9460 
                 13 
               
               
                 GCU 
                 7 
                 2 
                 3,741,695 
                 3,506,723 
                 2,667,236 
                 76.1% 
                 0.9348 
                 11 
               
               
                 GCC 
                 7 
                 3 
                 3,236,164 
                 2,627,147 
                 1,752,991 
                 66.7% 
                 0.9554 
                 7 
               
               
                 GCG 
                 7 
                 3 
                 4,033,566 
                 2,305,468 
                 1,704,092 
                 73.9% 
                 0.9737 
                 4 
               
               
                 GUA 
                 2 
                 1 
                 3,131,513 
                 1,847,377 
                 824,577 
                 44.6% 
                 0.9191 
                 2 
               
               
                 GUU 
                 8 
                 1 
                 3,347,839 
                 3,036,625 
                 2,037,159 
                 67.1% 
                 0.8761 
                 6 
               
               
                 GUC 
                 1 
                 2 
                 3,048,292 
                 2,591,672 
                 1,619,189 
                 62.5% 
                 0.9666 
                 6 
               
               
                 GUG 
                 4 
                 2 
                 2,472,107 
                 1,896,957 
                 1,195,374 
                 63.0% 
                 0.7264 
                 23 
               
               
                 GGA 
                 2 
                 2 
                 3,092,035 
                 2,550,386 
                 1,405,444 
                 55.1% 
                 0.8136 
                 6 
               
               
                 GGC 
                 3 
                 3 
                 3,190,015 
                 1,377,083 
                 911,604 
                 66.2% 
                 0.8605 
                 10 
               
               
                 GGU 
                 2 
                 2 
                 2,475,086 
                 1,979,666 
                 1,212,320 
                 61.2% 
                 0.9597 
                 7 
               
               
                 GGG 
                 3 
                 3 
                 4,653,050 
                 1,637,713 
                 977,341 
                 59.7% 
                 0.7433 
                 19 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                 Rank 
                 miRNA 
                 AAA 
                 AAT 
                 CTC 
                 CTT 
                 GGG 
                 GTG 
                 TCA 
                 TCC 
                 sum 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 miRExpress software 
               
             
          
           
               
                 1 
                 hsa-miR-143 
                 629047 
                 596534 
                 264042 
                 259410 
                 49059 
                 100716 
                 59682 
                 21985 
                 1980475 
               
               
                 2 
                 hsa-miR-378 
                 36063 
                 53471 
                 42317 
                 54587 
                 16247 
                 28919 
                 126718 
                 57710 
                 416032 
               
               
                 3 
                 hsa-miR-1 
                 57848 
                 44332 
                 39707 
                 10420 
                 71826 
                 135691 
                 29183 
                 16259 
                 405266 
               
               
                 4 
                 hsa-miR-21 
                 56293 
                 54594 
                 30282 
                 46590 
                 12227 
                 15423 
                 73223 
                 35705 
                 324337 
               
               
                 5 
                 hsa-miR-30a 
                 18225 
                 21466 
                 16951 
                 22039 
                 9302 
                 13824 
                 71561 
                 25377 
                 198745 
               
               
                 6 
                 hsa-let-7a 
                 73073 
                 55464 
                 6234 
                 8420 
                 8281 
                 10661 
                 15513 
                 5619 
                 183265 
               
               
                 7 
                 hsa-let-7f 
                 80747 
                 61375 
                 3623 
                 6323 
                 4201 
                 9192 
                 11917 
                 4434 
                 181812 
               
               
                 8 
                 hsa-miR-126 
                 21192 
                 17954 
                 10190 
                 13560 
                 10448 
                 25185 
                 32341 
                 8650 
                 139520 
               
               
                 9 
                 hsa-miR-26a 
                 18178 
                 12543 
                 15896 
                 37425 
                 6207 
                 9273 
                 16873 
                 9698 
                 126093 
               
               
                 10 
                 hsa-miR-148a 
                 13804 
                 11033 
                 13926 
                 20902 
                 12155 
                 5385 
                 12584 
                 2984 
                 92773 
               
               
                 11 
                 hsa-miR-215 
                 12043 
                 10792 
                 13911 
                 6560 
                 3232 
                 17876 
                 18218 
                 5473 
                 88105 
               
               
                 12 
                 hsa-miR-192 
                 11751 
                 11388 
                 8808 
                 6573 
                 5710 
                 9914 
                 19675 
                 6537 
                 80356 
               
               
                 13 
                 hsa-miR-101 
                 7582 
                 8456 
                 7582 
                 10921 
                 3174 
                 6450 
                 20984 
                 10424 
                 75573 
               
               
                 14 
                 hsa-miR-30d 
                 9416 
                 9847 
                 7963 
                 8538 
                 4882 
                 8059 
                 15766 
                 6778 
                 71249 
               
               
                 15 
                 hsa-miR-10b 
                 9009 
                 10431 
                 6283 
                 7604 
                 4005 
                 4395 
                 19467 
                 9012 
                 70206 
               
               
                 16 
                 hsa-miR-451 
                 15361 
                 10057 
                 7584 
                 7501 
                 2597 
                 2635 
                 10609 
                 6821 
                 63165 
               
               
                 17 
                 hsa-miR-145 
                 2744 
                 2847 
                 10661 
                 9089 
                 4226 
                 7679 
                 11457 
                 8859 
                 57562 
               
               
                 18 
                 hsa-miR-27b 
                 8511 
                 6649 
                 7872 
                 9957 
                 3741 
                 2958 
                 9543 
                 4668 
                 53899 
               
               
                 19 
                 hsa-miR-140-3p 
                 7200 
                 6803 
                 7626 
                 10477 
                 3511 
                 3559 
                 6379 
                 5750 
                 51305 
               
               
                 20 
                 hsa-miR-24 
                 5128 
                 3009 
                 9244 
                 3013 
                 7118 
                 9415 
                 7554 
                 4633 
                 49114 
               
             
          
           
               
                 Novoalign software 
               
             
          
           
               
                 1 
                 hsa-miR-143 
                 619600 
                 588860 
                 261006 
                 257701 
                 57043 
                 99605 
                 60485 
                 21845 
                 1966145 
               
               
                 2 
                 hsa-miR-1 
                 58842 
                 45204 
                 39539 
                 10656 
                 74017 
                 137450 
                 29480 
                 16454 
                 411642 
               
               
                 3 
                 hsa-miR-21 
                 56707 
                 54428 
                 30261 
                 46984 
                 12404 
                 15381 
                 73132 
                 35673 
                 324970 
               
               
                 4 
                 hsa-miR-378 
                 34181 
                 51292 
                 40421 
                 52081 
                 16619 
                 27345 
                 119105 
                 54877 
                 395921 
               
               
                 5 
                 hsa-let-7f 
                 81639 
                 62336 
                 3727 
                 6472 
                 4770 
                 9475 
                 12242 
                 4524 
                 185185 
               
               
                 6 
                 hsa-let-7a 
                 72376 
                 55159 
                 6190 
                 8391 
                 8775 
                 13750 
                 15523 
                 5614 
                 185778 
               
               
                 7 
                 hsa-miR-30a 
                 18195 
                 21486 
                 16923 
                 22285 
                 9600 
                 13915 
                 71336 
                 25348 
                 199088 
               
               
                 8 
                 hsa-miR-26a 
                 17701 
                 12617 
                 15479 
                 38064 
                 6365 
                 8978 
                 16648 
                 9446 
                 125298 
               
               
                 9 
                 hsa-miR-126 
                 20722 
                 17592 
                 9962 
                 13332 
                 10604 
                 24737 
                 31622 
                 8487 
                 137058 
               
               
                 10 
                 hsa-miR-24 
                 5094 
                 2979 
                 9192 
                 3026 
                 7340 
                 9417 
                 7490 
                 4594 
                 49132 
               
               
                 11 
                 hsa-miR-148a 
                 13547 
                 10840 
                 13693 
                 20651 
                 12760 
                 5338 
                 12467 
                 2945 
                 92241 
               
               
                 12 
                 hsa-miR-215 
                 11939 
                 13790 
                 13676 
                 6407 
                 3774 
                 17552 
                 17856 
                 5352 
                 90346 
               
               
                 13 
                 hsa-miR-192 
                 11557 
                 11232 
                 8651 
                 6496 
                 5648 
                 9717 
                 19311 
                 6395 
                 79007 
               
               
                 14 
                 hsa-miR-30d 
                 9362 
                 9801 
                 7964 
                 8616 
                 4963 
                 8177 
                 15716 
                 6767 
                 71366 
               
               
                 15 
                 hsa-miR-101 
                 7589 
                 8328 
                 7469 
                 10798 
                 3144 
                 6385 
                 20665 
                 10339 
                 74717 
               
               
                 16 
                 hsa-miR-146b-5p 
                 6947 
                 6492 
                 3325 
                 3180 
                 8576 
                 7638 
                 10232 
                 1814 
                 48204 
               
               
                 17 
                 hsa-miR-145 
                 2685 
                 2797 
                 10421 
                 8912 
                 4111 
                 7447 
                 11085 
                 8628 
                 56086 
               
               
                 18 
                 hsa-miR-451 
                 15263 
                 9893 
                 7453 
                 7354 
                 2578 
                 2577 
                 10438 
                 6706 
                 62262 
               
               
                 19 
                 hsa-miR-10b 
                 8838 
                 10204 
                 6145 
                 7515 
                 4054 
                 4383 
                 19157 
                 8867 
                 69163 
               
               
                 20 
                 hsa-miR-27b 
                 8140 
                 6394 
                 7546 
                 10720 
                 3945 
                 2848 
                 9217 
                 4493 
                 53303 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                   
                 Human RNA pool 
                   
               
               
                   
                 adaptors 
                 Breast 
               
             
          
           
               
                 RNA 
                 Default 
                 8 × 8 
                 16 × 4 
                 32 × 2 
                 64 × 1 
                 8 × 8 
                 8 × 8 
               
               
                 miRNA 
                 (lane 1) 
                 (lane 2) 
                 (lane 3) 
                 (lane 4) 
                 (lane 5) 
                 (lane 6) 
                 (lane 7) 
               
               
                   
               
             
          
           
               
                 hsa-let-7a 
                 182815 
                 207044 
                 201770 
                 228567 
                 250250 
                 229745 
                 285909 
               
               
                 hsa-let-7a* 
                 191 
                 183 
                 156 
                 229 
                 243 
                 178 
                 321 
               
               
                 hsa-let-7a-2* 
                 0 
                 10 
                 14 
                 22 
                 19 
                 13 
                 8 
               
               
                 hsa-let-7b 
                 3732 
                 38250 
                 37832 
                 43779 
                 45636 
                 42083 
                 104331 
               
               
                 hsa-let-7b* 
                 7 
                 168 
                 150 
                 202 
                 204 
                 167 
                 305 
               
               
                 hsa-let-7c 
                 4493 
                 38771 
                 37083 
                 42216 
                 46566 
                 42940 
                 42483 
               
               
                 hsa-let-7c* 
                 1 
                 2 
                 4 
                 2 
                 5 
                 3 
                 6 
               
               
                 hsa-let-7d 
                 9918 
                 4502 
                 4469 
                 5067 
                 4961 
                 4926 
                 3779 
               
               
                 hsa-let-7d* 
                 698 
                 958 
                 929 
                 1221 
                 1170 
                 1079 
                 1078 
               
               
                 hsa-let-7e 
                 249 
                 8159 
                 7300 
                 7306 
                 6986 
                 9357 
                 6280 
               
               
                 hsa-let-7e* 
                 0 
                 51 
                 58 
                 78 
                 81 
                 77 
                 47 
               
               
                 hsa-let-7f 
                 510653 
                 201473 
                 192459 
                 203236 
                 227113 
                 225547 
                 159271 
               
               
                 hsa-let-7f-1* 
                 62 
                 20 
                 20 
                 32 
                 18 
                 16 
                 28 
               
               
                 hsa-let-7f-2* 
                 80 
                 2 
                 6 
                 4 
                 5 
                 5 
                 9 
               
               
                 hsa-let-7g 
                 72910 
                 42837 
                 43556 
                 50078 
                 53190 
                 47164 
                 53943 
               
               
                 hsa-let-7g* 
                 43 
                 219 
                 245 
                 315 
                 328 
                 256 
                 167 
               
               
                 hsa-let-7i 
                 5027 
                 8012 
                 7610 
                 8665 
                 8993 
                 8867 
                 9347 
               
               
                 hsa-let-7i* 
                 113 
                 304 
                 314 
                 419 
                 420 
                 318 
                 426 
               
               
                 hsa-miR-1 
                 39 
                 404787 
                 408176 
                 485549 
                 509267 
                 450370 
                 1790 
               
               
                 hsa-miR-100 
                 1 
                 24727 
                 23218 
                 27907 
                 27055 
                 26815 
                 6954 
               
               
                 hsa-miR-100* 
                 0 
                 38 
                 27 
                 39 
                 33 
                 30 
                 5 
               
               
                 hsa-miR-101 
                 194516 
                 55392 
                 50631 
                 59094 
                 59555 
                 61050 
                 47642 
               
               
                 hsa-miR-101* 
                 133 
                 369 
                 376 
                 446 
                 444 
                 413 
                 235 
               
               
                 hsa-miR-103 
                 97269 
                 20956 
                 17889 
                 14087 
                 12536 
                 23100 
                 8047 
               
               
                 hsa-miR-103-2* 
                 37 
                 20 
                 14 
                 31 
                 21 
                 20 
                 22 
               
               
                 hsa-miR-103-as 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-105 
                 0 
                 11 
                 8 
                 18 
                 10 
                 7 
                 0 
               
               
                 hsa-miR-105* 
                 0 
                 0 
                 2 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-106a 
                 394 
                 2073 
                 2034 
                 2465 
                 2622 
                 2258 
                 829 
               
               
                 hsa-miR-106a* 
                 0 
                 4 
                 11 
                 10 
                 9 
                 13 
                 2 
               
               
                 hsa-miR-106b 
                 35123 
                 3419 
                 3847 
                 4164 
                 4238 
                 3699 
                 1679 
               
               
                 hsa-miR-106b* 
                 1664 
                 114 
                 108 
                 154 
                 119 
                 137 
                 136 
               
               
                 hsa-miR-107 
                 628 
                 274 
                 282 
                 274 
                 209 
                 308 
                 159 
               
               
                 hsa-miR-10a 
                 186 
                 26956 
                 24934 
                 27899 
                 28106 
                 29258 
                 17837 
               
               
                 hsa-miR-10a* 
                 0 
                 115 
                 112 
                 129 
                 148 
                 136 
                 123 
               
               
                 hsa-miR-10b 
                 7 
                 40830 
                 37049 
                 43481 
                 43238 
                 44884 
                 40079 
               
               
                 hsa-miR-10b* 
                 0 
                 361 
                 326 
                 359 
                 416 
                 368 
                 469 
               
               
                 hsa-miR-1178 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1179 
                 5 
                 77 
                 69 
                 91 
                 81 
                 90 
                 16 
               
               
                 hsa-miR-1180 
                 0 
                 21 
                 17 
                 14 
                 28 
                 31 
                 15 
               
               
                 hsa-miR-1181 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1182 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1183 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1184 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1185 
                 0 
                 26 
                 35 
                 47 
                 48 
                 35 
                 7 
               
               
                 hsa-miR-1193 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1197 
                 0 
                 1 
                 3 
                 0 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-1200 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1201 
                 422 
                 56 
                 55 
                 63 
                 66 
                 91 
                 69 
               
               
                 hsa-miR-1202 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1203 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1204 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1205 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1206 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1207-3p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1207-5p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1208 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-122 
                 4 
                 5808 
                 5666 
                 6201 
                 6163 
                 6375 
                 81 
               
               
                 hsa-miR-122* 
                 0 
                 57 
                 56 
                 78 
                 85 
                 66 
                 2 
               
               
                 hsa-miR-1224-3p 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1224-5p 
                 0 
                 13 
                 12 
                 8 
                 10 
                 10 
                 0 
               
               
                 hsa-miR-1225-3p 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1225-5p 
                 0 
                 0 
                 0 
                 2 
                 1 
                 1 
                 2 
               
               
                 hsa-miR-1226 
                 6 
                 1 
                 2 
                 2 
                 6 
                 2 
                 1 
               
               
                 hsa-miR-1226* 
                 7 
                 0 
                 0 
                 3 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1227 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1228 
                 0 
                 1 
                 1 
                 0 
                 1 
                 2 
                 2 
               
               
                 hsa-miR-1228* 
                 0 
                 0 
                 1 
                 1 
                 1 
                 0 
                 1 
               
               
                 hsa-miR-1229 
                 1 
                 2 
                 0 
                 4 
                 1 
                 1 
                 0 
               
               
                 hsa-miR-1231 
                 0 
                 1 
                 2 
                 0 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-1233 
                 0 
                 1 
                 1 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1234 
                 1 
                 1 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-1236 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1237 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1238 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-124 
                 0 
                 1249 
                 1154 
                 1262 
                 1285 
                 1408 
                 2 
               
               
                 hsa-miR-124* 
                 0 
                 5 
                 1 
                 6 
                 4 
                 5 
                 0 
               
               
                 hsa-miR-1243 
                 5 
                 5 
                 2 
                 0 
                 1 
                 3 
                 2 
               
               
                 hsa-miR-1244 
                 0 
                 3 
                 1 
                 7 
                 1 
                 5 
                 2 
               
               
                 hsa-miR-1245 
                 0 
                 0 
                 1 
                 1 
                 3 
                 1 
                 2 
               
               
                 hsa-miR-1246 
                 49235 
                 5920 
                 5881 
                 6452 
                 6358 
                 6490 
                 37368 
               
               
                 hsa-miR-1247 
                 0 
                 92 
                 92 
                 112 
                 120 
                 93 
                 46 
               
               
                 hsa-miR-1248 
                 2 
                 28 
                 22 
                 22 
                 19 
                 16 
                 27 
               
               
                 hsa-miR-1249 
                 1 
                 25 
                 26 
                 31 
                 32 
                 29 
                 11 
               
               
                 hsa-miR-1250 
                 0 
                 4 
                 1 
                 1 
                 0 
                 2 
                 0 
               
               
                 hsa-miR-1251 
                 0 
                 110 
                 82 
                 133 
                 128 
                 137 
                 0 
               
               
                 hsa-miR-1252 
                 0 
                 1 
                 2 
                 1 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-1253 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1254 
                 34 
                 1 
                 3 
                 12 
                 7 
                 8 
                 2 
               
               
                 hsa-miR-1255a 
                 46 
                 6 
                 12 
                 11 
                 11 
                 5 
                 4 
               
               
                 hsa-miR-1255b 
                 6 
                 3 
                 3 
                 11 
                 2 
                 7 
                 3 
               
               
                 hsa-miR-1256 
                 5 
                 0 
                 4 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1257 
                 27 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1258 
                 0 
                 2 
                 3 
                 1 
                 4 
                 1 
                 2 
               
               
                 hsa-miR-1259 
                 268 
                 38 
                 29 
                 29 
                 30 
                 43 
                 69 
               
               
                 hsa-miR-125a-3p 
                 0 
                 76 
                 63 
                 69 
                 62 
                 59 
                 46 
               
               
                 hsa-miR-125a-5p 
                 3 
                 14695 
                 14391 
                 16483 
                 15940 
                 16054 
                 8971 
               
               
                 hsa-miR-125b 
                 738 
                 30693 
                 29479 
                 33392 
                 32497 
                 33293 
                 16929 
               
               
                 hsa-miR-125b-1* 
                 0 
                 70 
                 64 
                 65 
                 65 
                 81 
                 59 
               
               
                 hsa-miR-125b-2* 
                 421 
                 1017 
                 994 
                 1074 
                 1037 
                 1170 
                 640 
               
               
                 hsa-miR-126 
                 2 
                 163374 
                 163020 
                 188443 
                 191489 
                 175101 
                 137109 
               
               
                 hsa-miR-126* 
                 2 
                 24037 
                 23282 
                 29250 
                 28209 
                 26553 
                 25398 
               
               
                 hsa-miR-1260 
                 5 
                 0 
                 3 
                 0 
                 3 
                 2 
                 1 
               
               
                 hsa-miR-1260b 
                 60 
                 14 
                 16 
                 15 
                 11 
                 12 
                 8 
               
               
                 hsa-miR-1261 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1262 
                 0 
                 12 
                 7 
                 11 
                 9 
                 17 
                 12 
               
               
                 hsa-miR-1263 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1264 
                 0 
                 0 
                 1 
                 2 
                 1 
                 2 
                 0 
               
               
                 hsa-miR-1265 
                 0 
                 3 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1266 
                 0 
                 5 
                 3 
                 3 
                 4 
                 0 
                 8 
               
               
                 hsa-miR-1267 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1268 
                 504 
                 20 
                 22 
                 30 
                 24 
                 20 
                 9 
               
               
                 hsa-miR-1269 
                 0 
                 14 
                 15 
                 13 
                 14 
                 13 
                 0 
               
               
                 hsa-miR-1270 
                 474 
                 66 
                 47 
                 48 
                 67 
                 74 
                 37 
               
               
                 hsa-miR-1271 
                 0 
                 50 
                 48 
                 58 
                 58 
                 40 
                 39 
               
               
                 hsa-miR-1272 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-1273 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1273c 
                 5 
                 2 
                 3 
                 5 
                 4 
                 7 
                 4 
               
               
                 hsa-miR-1273d 
                 3 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-127-3p 
                 3 
                 1993 
                 1787 
                 2084 
                 2026 
                 2092 
                 1242 
               
               
                 hsa-miR-1274a 
                 9 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1274b 
                 40 
                 64 
                 61 
                 70 
                 72 
                 49 
                 23 
               
               
                 hsa-miR-1275 
                 192 
                 25 
                 27 
                 36 
                 23 
                 30 
                 16 
               
               
                 hsa-miR-127-5p 
                 0 
                 343 
                 290 
                 391 
                 386 
                 362 
                 69 
               
               
                 hsa-miR-1276 
                 23 
                 1 
                 0 
                 0 
                 2 
                 1 
                 0 
               
               
                 hsa-miR-1277 
                 79 
                 39 
                 22 
                 37 
                 26 
                 32 
                 4 
               
               
                 hsa-miR-1278 
                 21 
                 1 
                 1 
                 1 
                 1 
                 2 
                 0 
               
               
                 hsa-miR-1279 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-128 
                 1231 
                 2133 
                 2052 
                 2282 
                 2117 
                 2319 
                 262 
               
               
                 hsa-miR-1280 
                 2 
                 9 
                 8 
                 14 
                 5 
                 14 
                 7 
               
               
                 hsa-miR-1281 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1282 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1283 
                 0 
                 251 
                 238 
                 288 
                 268 
                 276 
                 1 
               
               
                 hsa-miR-1284 
                 5 
                 2 
                 1 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1285 
                 412 
                 13 
                 15 
                 21 
                 12 
                 16 
                 13 
               
               
                 hsa-miR-1286 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1287 
                 1 
                 35 
                 31 
                 32 
                 49 
                 30 
                 40 
               
               
                 hsa-miR-1288 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1289 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-129* 
                 3 
                 26 
                 29 
                 28 
                 15 
                 30 
                 0 
               
               
                 hsa-miR-1290 
                 3 
                 0 
                 0 
                 0 
                 1 
                 0 
                 1 
               
               
                 hsa-miR-1291 
                 47 
                 38 
                 13 
                 25 
                 27 
                 18 
                 16 
               
               
                 hsa-miR-1292 
                 162 
                 20 
                 39 
                 31 
                 32 
                 24 
                 29 
               
               
                 hsa-miR-1293 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-129-3p 
                 3 
                 84 
                 78 
                 84 
                 98 
                 102 
                 1 
               
               
                 hsa-miR-1294 
                 4 
                 2 
                 1 
                 2 
                 7 
                 3 
                 2 
               
               
                 hsa-miR-1295 
                 0 
                 1 
                 3 
                 1 
                 2 
                 2 
                 6 
               
               
                 hsa-miR-129-5p 
                 4 
                 280 
                 267 
                 306 
                 326 
                 311 
                 3 
               
               
                 hsa-miR-1296 
                 10 
                 50 
                 52 
                 53 
                 65 
                 49 
                 47 
               
               
                 hsa-miR-1297 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1298 
                 0 
                 15 
                 13 
                 16 
                 14 
                 18 
                 0 
               
               
                 hsa-miR-1299 
                 15 
                 51 
                 61 
                 45 
                 63 
                 58 
                 66 
               
               
                 hsa-miR-1301 
                 1 
                 49 
                 45 
                 48 
                 50 
                 50 
                 14 
               
               
                 hsa-miR-1302 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1303 
                 27 
                 7 
                 5 
                 7 
                 8 
                 17 
                 7 
               
               
                 hsa-miR-1304 
                 7 
                 3 
                 1 
                 3 
                 2 
                 3 
                 0 
               
               
                 hsa-miR-1305 
                 0 
                 2 
                 8 
                 6 
                 7 
                 5 
                 5 
               
               
                 hsa-miR-1306 
                 1 
                 0 
                 3 
                 2 
                 3 
                 1 
                 5 
               
               
                 hsa-miR-1307 
                 1860 
                 328 
                 292 
                 362 
                 324 
                 337 
                 196 
               
               
                 hsa-miR-1308 
                 722 
                 471 
                 506 
                 521 
                 567 
                 519 
                 206 
               
               
                 hsa-miR-130a 
                 4 
                 2674 
                 2388 
                 2934 
                 2721 
                 2777 
                 2772 
               
               
                 hsa-miR-130a* 
                 0 
                 5 
                 2 
                 6 
                 8 
                 6 
                 13 
               
               
                 hsa-miR-130b 
                 3376 
                 456 
                 434 
                 625 
                 526 
                 455 
                 217 
               
               
                 hsa-miR-130b* 
                 81 
                 85 
                 63 
                 66 
                 63 
                 72 
                 21 
               
               
                 hsa-miR-132 
                 77 
                 750 
                 687 
                 834 
                 904 
                 797 
                 686 
               
               
                 hsa-miR-132* 
                 6 
                 125 
                 110 
                 117 
                 116 
                 119 
                 57 
               
               
                 hsa-miR-1321 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-1322 
                 4 
                 1 
                 2 
                 0 
                 0 
                 2 
                 0 
               
               
                 hsa-miR-1323 
                 0 
                 3503 
                 3317 
                 2994 
                 2327 
                 3903 
                 8 
               
               
                 hsa-miR-1324 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-133a 
                 2 
                 18167 
                 18669 
                 22360 
                 22448 
                 19771 
                 51 
               
               
                 hsa-miR-133b 
                 0 
                 556 
                 566 
                 637 
                 624 
                 553 
                 2 
               
               
                 hsa-miR-134 
                 0 
                 172 
                 171 
                 185 
                 212 
                 192 
                 200 
               
               
                 hsa-miR-135a 
                 1 
                 9461 
                 8663 
                 9893 
                 7606 
                 10424 
                 105 
               
               
                 hsa-miR-135a* 
                 0 
                 6 
                 6 
                 4 
                 8 
                 9 
                 0 
               
               
                 hsa-miR-135b 
                 0 
                 2934 
                 2829 
                 3189 
                 2875 
                 3219 
                 357 
               
               
                 hsa-miR-135b* 
                 0 
                 20 
                 11 
                 18 
                 17 
                 19 
                 7 
               
               
                 hsa-miR-136 
                 0 
                 2340 
                 1609 
                 1993 
                 1920 
                 2381 
                 500 
               
               
                 hsa-miR-136* 
                 1 
                 413 
                 380 
                 489 
                 489 
                 467 
                 170 
               
               
                 hsa-miR-137 
                 0 
                 509 
                 472 
                 442 
                 444 
                 548 
                 7 
               
               
                 hsa-miR-138 
                 3027 
                 968 
                 858 
                 1165 
                 1119 
                 984 
                 67 
               
               
                 hsa-miR-138-1* 
                 58 
                 27 
                 26 
                 26 
                 27 
                 27 
                 8 
               
               
                 hsa-miR-138-2* 
                 0 
                 8 
                 4 
                 6 
                 5 
                 4 
                 0 
               
               
                 hsa-miR-139-3p 
                 9 
                 125 
                 130 
                 105 
                 116 
                 131 
                 163 
               
               
                 hsa-miR-139-5p 
                 11 
                 1451 
                 1370 
                 1583 
                 1571 
                 1574 
                 1683 
               
               
                 hsa-miR-140-3p 
                 67006 
                 37936 
                 34949 
                 36311 
                 36598 
                 41136 
                 16014 
               
               
                 hsa-miR-140-5p 
                 3672 
                 6850 
                 6579 
                 8128 
                 7884 
                 7500 
                 5245 
               
               
                 hsa-miR-141 
                 79 
                 6530 
                 6644 
                 6908 
                 7685 
                 7532 
                 3759 
               
               
                 hsa-miR-141* 
                 0 
                 155 
                 128 
                 159 
                 131 
                 134 
                 152 
               
               
                 hsa-miR-142-3p 
                 169524 
                 71892 
                 68818 
                 82272 
                 79112 
                 77431 
                 8578 
               
               
                 hsa-miR-142-5p 
                 16201 
                 2014 
                 1877 
                 2148 
                 2101 
                 2323 
                 882 
               
               
                 hsa-miR-143 
                 17640 
                 1884521 
                 1792761 
                 2010306 
                 2107243 
                 2088207 
                 1074889 
               
               
                 hsa-miR-143* 
                 11 
                 14298 
                 14952 
                 19113 
                 18944 
                 15393 
                 4904 
               
               
                 hsa-miR-144 
                 0 
                 1335 
                 1046 
                 1285 
                 1271 
                 1455 
                 132 
               
               
                 hsa-miR-144* 
                 13 
                 7752 
                 7376 
                 8357 
                 8770 
                 8522 
                 3235 
               
               
                 hsa-miR-145 
                 40 
                 64408 
                 62487 
                 79740 
                 74320 
                 68219 
                 26847 
               
               
                 hsa-miR-145* 
                 3 
                 2495 
                 2415 
                 2993 
                 2747 
                 2567 
                 1465 
               
               
                 hsa-miR-1468 
                 1 
                 4 
                 5 
                 4 
                 8 
                 7 
                 1 
               
               
                 hsa-miR-1469 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-146a 
                 45680 
                 8759 
                 8469 
                 9841 
                 9877 
                 9557 
                 9883 
               
               
                 hsa-miR-146a* 
                 0 
                 2 
                 0 
                 4 
                 1 
                 3 
                 4 
               
               
                 hsa-miR-146b-3p 
                 40 
                 20 
                 10 
                 23 
                 25 
                 23 
                 46 
               
               
                 hsa-miR-146b-5p 
                 51686 
                 64507 
                 64864 
                 73443 
                 75492 
                 70909 
                 105601 
               
               
                 hsa-miR-147 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1470 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1471 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-147b 
                 0 
                 5 
                 8 
                 9 
                 7 
                 4 
                 13 
               
               
                 hsa-miR-148a 
                 167654 
                 83936 
                 69915 
                 67362 
                 59455 
                 92561 
                 55496 
               
               
                 hsa-miR-148a* 
                 2741 
                 231 
                 173 
                 236 
                 232 
                 238 
                 257 
               
               
                 hsa-miR-148b 
                 18296 
                 12418 
                 10163 
                 9757 
                 8603 
                 13625 
                 4727 
               
               
                 hsa-miR-148b* 
                 2605 
                 303 
                 339 
                 352 
                 366 
                 365 
                 204 
               
               
                 hsa-miR-149 
                 22 
                 198 
                 187 
                 269 
                 258 
                 224 
                 126 
               
               
                 hsa-miR-149* 
                 0 
                 2 
                 2 
                 1 
                 1 
                 4 
                 2 
               
               
                 hsa-miR-150 
                 1 
                 2028 
                 1981 
                 2312 
                 2285 
                 2182 
                 1767 
               
               
                 hsa-miR-150* 
                 0 
                 17 
                 26 
                 37 
                 30 
                 19 
                 6 
               
               
                 hsa-miR-151-3p 
                 4140 
                 9265 
                 8272 
                 9478 
                 9542 
                 9887 
                 6249 
               
               
                 hsa-miR-151-5p 
                 1069 
                 9893 
                 9391 
                 10906 
                 10349 
                 10836 
                 6486 
               
               
                 hsa-miR-152 
                 881 
                 12737 
                 10667 
                 10744 
                 9523 
                 13596 
                 9459 
               
               
                 hsa-miR-153 
                 5 
                 314 
                 247 
                 325 
                 302 
                 316 
                 54 
               
               
                 hsa-miR-1537 
                 0 
                 3 
                 1 
                 2 
                 3 
                 3 
                 0 
               
               
                 hsa-miR-1538 
                 0 
                 1 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1539 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-154 
                 0 
                 65 
                 59 
                 72 
                 72 
                 93 
                 24 
               
               
                 hsa-miR-154* 
                 0 
                 32 
                 27 
                 17 
                 28 
                 20 
                 4 
               
               
                 hsa-miR-155 
                 118345 
                 3723 
                 3704 
                 4428 
                 4788 
                 4169 
                 2397 
               
               
                 hsa-miR-155* 
                 477 
                 0 
                 1 
                 1 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-15a 
                 11248 
                 2927 
                 2588 
                 3145 
                 3253 
                 2998 
                 1562 
               
               
                 hsa-miR-15a* 
                 8 
                 3 
                 3 
                 4 
                 1 
                 6 
                 2 
               
               
                 hsa-miR-15b 
                 4272 
                 1346 
                 1127 
                 1151 
                 1156 
                 1456 
                 1012 
               
               
                 hsa-miR-15b* 
                 712 
                 92 
                 78 
                 100 
                 95 
                 101 
                 50 
               
               
                 hsa-miR-16 
                 25236 
                 33304 
                 35260 
                 36274 
                 35048 
                 35434 
                 22850 
               
               
                 hsa-miR-16-1* 
                 242 
                 6 
                 12 
                 9 
                 4 
                 6 
                 2 
               
               
                 hsa-miR-16-2* 
                 277 
                 81 
                 97 
                 115 
                 90 
                 77 
                 92 
               
               
                 hsa-miR-17 
                 75571 
                 8032 
                 7314 
                 9397 
                 9426 
                 8462 
                 3575 
               
               
                 hsa-miR-17* 
                 7638 
                 396 
                 347 
                 387 
                 360 
                 469 
                 69 
               
               
                 hsa-miR-181a 
                 14796 
                 21358 
                 19352 
                 24301 
                 24133 
                 24053 
                 7752 
               
               
                 hsa-miR-181a* 
                 977 
                 244 
                 223 
                 282 
                 287 
                 246 
                 53 
               
               
                 hsa-miR-181a-2* 
                 4 
                 267 
                 221 
                 301 
                 249 
                 267 
                 96 
               
               
                 hsa-miR-181b 
                 3623 
                 2995 
                 2745 
                 3337 
                 3228 
                 3420 
                 1302 
               
               
                 hsa-miR-181c 
                 15 
                 594 
                 605 
                 682 
                 662 
                 698 
                 314 
               
               
                 hsa-miR-181c* 
                 4 
                 64 
                 78 
                 75 
                 83 
                 95 
                 45 
               
               
                 hsa-miR-181d 
                 16 
                 333 
                 312 
                 372 
                 358 
                 373 
                 231 
               
               
                 hsa-miR-182 
                 17542 
                 4447 
                 3961 
                 4784 
                 4611 
                 4786 
                 20534 
               
               
                 hsa-miR-182* 
                 0 
                 3 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-1825 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1826 
                 201 
                 209 
                 183 
                 222 
                 226 
                 236 
                 145 
               
               
                 hsa-miR-1827 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-183 
                 4237 
                 1068 
                 920 
                 1093 
                 972 
                 1165 
                 3294 
               
               
                 hsa-miR-183* 
                 48 
                 3 
                 2 
                 3 
                 4 
                 1 
                 8 
               
               
                 hsa-miR-184 
                 178 
                 266 
                 245 
                 274 
                 292 
                 312 
                 47 
               
               
                 hsa-miR-185 
                 1420 
                 917 
                 965 
                 1062 
                 1034 
                 1015 
                 640 
               
               
                 hsa-miR-185* 
                 21 
                 15 
                 14 
                 11 
                 8 
                 17 
                 8 
               
               
                 hsa-miR-186 
                 23895 
                 10864 
                 11534 
                 15131 
                 14516 
                 11876 
                 9468 
               
               
                 hsa-miR-186* 
                 242 
                 18 
                 13 
                 13 
                 12 
                 18 
                 7 
               
               
                 hsa-miR-187 
                 0 
                 61 
                 66 
                 77 
                 62 
                 76 
                 24 
               
               
                 hsa-miR-187* 
                 0 
                 6 
                 4 
                 9 
                 4 
                 4 
                 0 
               
               
                 hsa-miR-188-3p 
                 0 
                 5 
                 4 
                 4 
                 1 
                 3 
                 5 
               
               
                 hsa-miR-188-5p 
                 0 
                 66 
                 48 
                 61 
                 48 
                 71 
                 46 
               
               
                 hsa-miR-18a 
                 9458 
                 450 
                 481 
                 506 
                 575 
                 498 
                 132 
               
               
                 hsa-miR-18a* 
                 105 
                 16 
                 15 
                 22 
                 10 
                 8 
                 14 
               
               
                 hsa-miR-18b 
                 14 
                 17 
                 10 
                 12 
                 12 
                 21 
                 4 
               
               
                 hsa-miR-18b* 
                 0 
                 3 
                 2 
                 1 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-190 
                 682 
                 1085 
                 1022 
                 1248 
                 1277 
                 1256 
                 529 
               
               
                 hsa-miR-1908 
                 0 
                 1 
                 0 
                 0 
                 1 
                 4 
                 0 
               
               
                 hsa-miR-1909 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1909* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-190b 
                 3 
                 17 
                 16 
                 28 
                 30 
                 22 
                 258 
               
               
                 hsa-miR-191 
                 49626 
                 21938 
                 20938 
                 23858 
                 21723 
                 24104 
                 14960 
               
               
                 hsa-miR-191* 
                 85 
                 7 
                 9 
                 7 
                 8 
                 10 
                 3 
               
               
                 hsa-miR-1910 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1911 
                 0 
                 12 
                 11 
                 3 
                 13 
                 8 
                 0 
               
               
                 hsa-miR-1911* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1912 
                 0 
                 3 
                 1 
                 5 
                 3 
                 3 
                 0 
               
               
                 hsa-miR-1913 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-1914 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-1914* 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1915 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-1915* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-192 
                 12660 
                 67252 
                 64208 
                 78702 
                 77501 
                 72613 
                 1512 
               
               
                 hsa-miR-192* 
                 13 
                 108 
                 96 
                 114 
                 116 
                 86 
                 9 
               
               
                 hsa-miR-193a-3p 
                 2 
                 321 
                 195 
                 260 
                 226 
                 300 
                 597 
               
               
                 hsa-miR-193a-5p 
                 0 
                 274 
                 240 
                 270 
                 305 
                 250 
                 1038 
               
               
                 hsa-miR-193b 
                 3731 
                 1819 
                 1714 
                 2035 
                 1909 
                 1997 
                 3930 
               
               
                 hsa-miR-193b* 
                 387 
                 53 
                 61 
                 65 
                 56 
                 69 
                 131 
               
               
                 hsa-miR-194 
                 1023 
                 29917 
                 30929 
                 37348 
                 37266 
                 32599 
                 483 
               
               
                 hsa-miR-194* 
                 23 
                 46 
                 41 
                 43 
                 42 
                 49 
                 1 
               
               
                 hsa-miR-195 
                 1 
                 5404 
                 5286 
                 4950 
                 4646 
                 5711 
                 8702 
               
               
                 hsa-miR-195* 
                 0 
                 24 
                 26 
                 30 
                 34 
                 35 
                 41 
               
               
                 hsa-miR-196a 
                 59 
                 559 
                 574 
                 687 
                 745 
                 676 
                 623 
               
               
                 hsa-miR-196a* 
                 3 
                 1 
                 0 
                 3 
                 2 
                 1 
                 1 
               
               
                 hsa-miR-196b 
                 0 
                 1600 
                 1451 
                 1723 
                 1821 
                 1707 
                 742 
               
               
                 hsa-miR-196b* 
                 0 
                 4 
                 2 
                 3 
                 0 
                 5 
                 2 
               
               
                 hsa-miR-197 
                 322 
                 1102 
                 1084 
                 1283 
                 1209 
                 1109 
                 865 
               
               
                 hsa-miR-1972 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-1973 
                 9 
                 9 
                 8 
                 5 
                 6 
                 10 
                 4 
               
               
                 hsa-miR-1975 
                 1004 
                 3292 
                 3615 
                 4209 
                 4391 
                 3345 
                 9392 
               
               
                 hsa-miR-1976 
                 10 
                 10 
                 4 
                 12 
                 4 
                 6 
                 4 
               
               
                 hsa-miR-1979 
                 1720 
                 1998 
                 1856 
                 2198 
                 2246 
                 2083 
                 14700 
               
               
                 hsa-miR-198 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-199a-3p 
                 5 
                 20978 
                 20327 
                 25304 
                 24599 
                 23143 
                 29779 
               
               
                 hsa-miR-199a-5p 
                 1 
                 3977 
                 3908 
                 4604 
                 4598 
                 4225 
                 5084 
               
               
                 hsa-miR-199b-3p 
                 5 
                 20978 
                 20327 
                 25304 
                 24599 
                 23143 
                 29779 
               
               
                 hsa-miR-199b-5p 
                 0 
                 957 
                 864 
                 1106 
                 1119 
                 1025 
                 2982 
               
               
                 hsa-miR-19a 
                 5598 
                 2533 
                 2848 
                 3908 
                 3726 
                 2702 
                 903 
               
               
                 hsa-miR-19a* 
                 18 
                 0 
                 1 
                 0 
                 1 
                 1 
                 0 
               
               
                 hsa-miR-19b 
                 18432 
                 9896 
                 10962 
                 14056 
                 13647 
                 10888 
                 9189 
               
               
                 hsa-miR-19b-1* 
                 256 
                 25 
                 22 
                 23 
                 20 
                 21 
                 13 
               
               
                 hsa-miR-19b-2* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-200a 
                 5 
                 2454 
                 2278 
                 2445 
                 2540 
                 2705 
                 1661 
               
               
                 hsa-miR-200a* 
                 0 
                 44 
                 53 
                 54 
                 49 
                 71 
                 47 
               
               
                 hsa-miR-200b 
                 2 
                 3797 
                 3888 
                 4427 
                 4654 
                 4284 
                 5020 
               
               
                 hsa-miR-200b* 
                 0 
                 410 
                 390 
                 415 
                 381 
                 413 
                 423 
               
               
                 hsa-miR-200c 
                 155 
                 30724 
                 29255 
                 31830 
                 33480 
                 34310 
                 43316 
               
               
                 hsa-miR-200c* 
                 2 
                 7 
                 11 
                 11 
                 12 
                 11 
                 6 
               
               
                 hsa-miR-202 
                 0 
                 366 
                 321 
                 280 
                 191 
                 397 
                 1 
               
               
                 hsa-miR-202* 
                 1 
                 7203 
                 6848 
                 8579 
                 8374 
                 8087 
                 86 
               
               
                 hsa-miR-203 
                 0 
                 4340 
                 3971 
                 4752 
                 4447 
                 4863 
                 1179 
               
               
                 hsa-miR-204 
                 0 
                 689 
                 695 
                 838 
                 784 
                 810 
                 67 
               
               
                 hsa-miR-205 
                 0 
                 5042 
                 4656 
                 5518 
                 5108 
                 5408 
                 55620 
               
               
                 hsa-miR-205* 
                 0 
                 2 
                 1 
                 3 
                 1 
                 0 
                 4 
               
               
                 hsa-miR-2052 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-2053 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-2054 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-206 
                 0 
                 13453 
                 13591 
                 15087 
                 16300 
                 15006 
                 4 
               
               
                 hsa-miR-208a 
                 0 
                 64 
                 34 
                 54 
                 43 
                 66 
                 0 
               
               
                 hsa-miR-208b 
                 0 
                 322 
                 319 
                 343 
                 304 
                 354 
                 0 
               
               
                 hsa-miR-20a 
                 138720 
                 9808 
                 9528 
                 10260 
                 10813 
                 10890 
                 5182 
               
               
                 hsa-miR-20a* 
                 454 
                 419 
                 476 
                 560 
                 521 
                 420 
                 168 
               
               
                 hsa-miR-20b 
                 2 
                 1344 
                 1204 
                 1591 
                 1628 
                 1459 
                 138 
               
               
                 hsa-miR-20b* 
                 0 
                 20 
                 13 
                 18 
                 20 
                 23 
                 3 
               
               
                 hsa-miR-21 
                 1852326 
                 331847 
                 313309 
                 353783 
                 377299 
                 368479 
                 300625 
               
               
                 hsa-miR-21* 
                 2992 
                 117 
                 104 
                 123 
                 126 
                 122 
                 102 
               
               
                 hsa-miR-210 
                 5008 
                 992 
                 971 
                 1242 
                 1326 
                 974 
                 254 
               
               
                 hsa-miR-211 
                 0 
                 2 
                 1 
                 4 
                 0 
                 3 
                 2 
               
               
                 hsa-miR-2110 
                 29 
                 93 
                 89 
                 60 
                 36 
                 105 
                 53 
               
               
                 hsa-miR-2113 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-2114 
                 0 
                 5 
                 7 
                 6 
                 5 
                 8 
                 1 
               
               
                 hsa-miR-2114* 
                 0 
                 0 
                 1 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-2115 
                 0 
                 3 
                 2 
                 1 
                 3 
                 2 
                 26 
               
               
                 hsa-miR-2115* 
                 0 
                 1 
                 7 
                 2 
                 1 
                 2 
                 40 
               
               
                 hsa-miR-2116 
                 1 
                 3 
                 4 
                 4 
                 5 
                 0 
                 1 
               
               
                 hsa-miR-2116* 
                 0 
                 2 
                 0 
                 3 
                 3 
                 3 
                 3 
               
               
                 hsa-miR-2117 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-212 
                 0 
                 25 
                 23 
                 25 
                 28 
                 24 
                 19 
               
               
                 hsa-miR-214 
                 0 
                 916 
                 830 
                 776 
                 685 
                 984 
                 1207 
               
               
                 hsa-miR-214* 
                 0 
                 167 
                 154 
                 183 
                 207 
                 209 
                 129 
               
               
                 hsa-miR-215 
                 142 
                 51160 
                 49148 
                 56830 
                 57666 
                 56128 
                 414 
               
               
                 hsa-miR-216a 
                 2 
                 20 
                 18 
                 25 
                 20 
                 18 
                 7 
               
               
                 hsa-miR-216b 
                 0 
                 70 
                 63 
                 76 
                 87 
                 74 
                 12 
               
               
                 hsa-miR-217 
                 7 
                 62 
                 47 
                 61 
                 54 
                 66 
                 20 
               
               
                 hsa-miR-218 
                 1 
                 2040 
                 2073 
                 2559 
                 2571 
                 2186 
                 1055 
               
               
                 hsa-miR-218-1* 
                 0 
                 56 
                 48 
                 63 
                 49 
                 58 
                 58 
               
               
                 hsa-miR-218-2* 
                 0 
                 0 
                 3 
                 2 
                 1 
                 4 
                 0 
               
               
                 hsa-miR-219-1- 
                 71 
                 2 
                 2 
                 1 
                 2 
                 6 
                 3 
               
               
                 3p 
                   
                   
                   
                   
                   
                   
                   
               
               
                 hsa-miR-219-2- 
                 0 
                 902 
                 1342 
                 1709 
                 1858 
                 2121 
                 2 
               
               
                 3p 
                   
                   
                   
                   
                   
                   
                   
               
               
                 hsa-miR-219-5p 
                 30 
                 44 
                 42 
                 53 
                 39 
                 41 
                 1 
               
               
                 hsa-miR-22 
                 926 
                 12597 
                 11782 
                 13008 
                 13488 
                 13549 
                 11463 
               
               
                 hsa-miR-22* 
                 53 
                 866 
                 967 
                 1293 
                 1130 
                 948 
                 1006 
               
               
                 hsa-miR-220a 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-220b 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-220c 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-221 
                 285 
                 3056 
                 3079 
                 3686 
                 3758 
                 3422 
                 2113 
               
               
                 hsa-miR-221* 
                 391 
                 1229 
                 999 
                 1015 
                 861 
                 1312 
                 389 
               
               
                 hsa-miR-222 
                 213 
                 7470 
                 7604 
                 9085 
                 8803 
                 8291 
                 5395 
               
               
                 hsa-miR-222* 
                 75 
                 38 
                 25 
                 39 
                 23 
                 33 
                 10 
               
               
                 hsa-miR-223 
                 3 
                 2838 
                 2663 
                 3045 
                 3179 
                 3067 
                 1895 
               
               
                 hsa-miR-223* 
                 1 
                 94 
                 117 
                 201 
                 183 
                 101 
                 51 
               
               
                 hsa-miR-224 
                 0 
                 587 
                 531 
                 684 
                 703 
                 650 
                 997 
               
               
                 hsa-miR-224* 
                 0 
                 28 
                 30 
                 30 
                 26 
                 34 
                 77 
               
               
                 hsa-miR-2276 
                 22 
                 6 
                 4 
                 6 
                 4 
                 8 
                 3 
               
               
                 hsa-miR-2277 
                 1 
                 4 
                 0 
                 6 
                 1 
                 4 
                 2 
               
               
                 hsa-miR-2278 
                 0 
                 0 
                 0 
                 1 
                 2 
                 0 
                 4 
               
               
                 hsa-miR-2355 
                 0 
                 5 
                 8 
                 9 
                 4 
                 3 
                 7 
               
               
                 hsa-miR-23a 
                 360 
                 15888 
                 14598 
                 17234 
                 16789 
                 17131 
                 21956 
               
               
                 hsa-miR-23a* 
                 3 
                 4 
                 3 
                 0 
                 0 
                 1 
                 3 
               
               
                 hsa-miR-23b 
                 474 
                 14755 
                 13404 
                 15889 
                 15851 
                 15682 
                 5726 
               
               
                 hsa-miR-23b* 
                 6 
                 21 
                 18 
                 17 
                 13 
                 16 
                 6 
               
               
                 hsa-miR-24 
                 1815 
                 116792 
                 122743 
                 140600 
                 135084 
                 126140 
                 67259 
               
               
                 hsa-miR-24-1* 
                 8 
                 276 
                 284 
                 347 
                 304 
                 343 
                 56 
               
               
                 hsa-miR-24-2* 
                 14 
                 584 
                 523 
                 594 
                 525 
                 558 
                 272 
               
               
                 hsa-miR-25 
                 7496 
                 1904 
                 1720 
                 1980 
                 1914 
                 2048 
                 1898 
               
               
                 hsa-miR-25* 
                 61 
                 30 
                 29 
                 23 
                 10 
                 38 
                 11 
               
               
                 hsa-miR-26a 
                 23823 
                 139238 
                 120963 
                 131441 
                 135641 
                 156484 
                 139950 
               
               
                 hsa-miR-26a-1* 
                 0 
                 4 
                 7 
                 5 
                 1 
                 6 
                 4 
               
               
                 hsa-miR-26a-2* 
                 58 
                 68 
                 51 
                 77 
                 70 
                 59 
                 63 
               
               
                 hsa-miR-26b 
                 11315 
                 37731 
                 28997 
                 31628 
                 32208 
                 42694 
                 29712 
               
               
                 hsa-miR-26b* 
                 43 
                 50 
                 54 
                 56 
                 63 
                 61 
                 59 
               
               
                 hsa-miR-27a 
                 362 
                 19157 
                 19019 
                 21101 
                 22219 
                 21482 
                 21448 
               
               
                 hsa-miR-27a* 
                 20 
                 43 
                 42 
                 73 
                 61 
                 49 
                 36 
               
               
                 hsa-miR-27b 
                 2465 
                 47617 
                 43110 
                 45439 
                 47218 
                 52830 
                 16131 
               
               
                 hsa-miR-27b* 
                 135 
                 633 
                 790 
                 963 
                 965 
                 725 
                 207 
               
               
                 hsa-miR-28-3p 
                 1396 
                 3372 
                 2921 
                 3435 
                 3485 
                 3521 
                 2162 
               
               
                 hsa-miR-28-5p 
                 1019 
                 3040 
                 2861 
                 3393 
                 3391 
                 3514 
                 3027 
               
               
                 hsa-miR-2861 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-2909 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-296-3p 
                 50 
                 4 
                 3 
                 4 
                 5 
                 4 
                 10 
               
               
                 hsa-miR-296-5p 
                 79 
                 32 
                 33 
                 46 
                 46 
                 30 
                 57 
               
               
                 hsa-miR-297 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-298 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-299-3p 
                 0 
                 33 
                 31 
                 32 
                 43 
                 40 
                 18 
               
               
                 hsa-miR-299-5p 
                 0 
                 72 
                 78 
                 91 
                 88 
                 71 
                 34 
               
               
                 hsa-miR-29a 
                 40124 
                 61875 
                 60909 
                 79815 
                 80527 
                 67864 
                 31795 
               
               
                 hsa-miR-29a* 
                 991 
                 294 
                 301 
                 347 
                 369 
                 332 
                 167 
               
               
                 hsa-miR-29b 
                 14193 
                 26166 
                 18024 
                 24954 
                 24981 
                 29084 
                 5148 
               
               
                 hsa-miR-29b-1* 
                 120 
                 16 
                 18 
                 28 
                 32 
                 19 
                 9 
               
               
                 hsa-miR-29b-2* 
                 147 
                 146 
                 115 
                 155 
                 155 
                 131 
                 87 
               
               
                 hsa-miR-29c 
                 1880 
                 3927 
                 3550 
                 4318 
                 4137 
                 4173 
                 3491 
               
               
                 hsa-miR-29c* 
                 162 
                 359 
                 397 
                 441 
                 421 
                 380 
                 317 
               
               
                 hsa-miR-300 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-301a 
                 421 
                 98 
                 82 
                 92 
                 93 
                 120 
                 10 
               
               
                 hsa-miR-301b 
                 169 
                 14 
                 13 
                 8 
                 16 
                 5 
                 1 
               
               
                 hsa-miR-302a 
                 0 
                 2 
                 3 
                 3 
                 2 
                 10 
                 0 
               
               
                 hsa-miR-302a* 
                 0 
                 12 
                 5 
                 13 
                 10 
                 12 
                 0 
               
               
                 hsa-miR-302b 
                 0 
                 4 
                 6 
                 14 
                 9 
                 9 
                 0 
               
               
                 hsa-miR-302b* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 2 
                 0 
               
               
                 hsa-miR-302c 
                 0 
                 2 
                 2 
                 1 
                 1 
                 1 
                 0 
               
               
                 hsa-miR-302c* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-302d 
                 0 
                 3 
                 1 
                 1 
                 1 
                 4 
                 0 
               
               
                 hsa-miR-302d* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-302e 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-302f 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3065-3p 
                 1 
                 112 
                 102 
                 122 
                 100 
                 116 
                 35 
               
               
                 hsa-miR-3065-5p 
                 0 
                 114 
                 114 
                 122 
                 119 
                 110 
                 22 
               
               
                 hsa-miR-3074 
                 1 
                 1 
                 0 
                 1 
                 1 
                 2 
                 1 
               
               
                 hsa-miR-30a 
                 425 
                 134091 
                 121854 
                 147246 
                 139908 
                 146572 
                 158595 
               
               
                 hsa-miR-30a* 
                 4 
                 5542 
                 4869 
                 5972 
                 5456 
                 5900 
                 8890 
               
               
                 hsa-miR-30b 
                 7820 
                 25303 
                 23222 
                 30378 
                 31188 
                 28066 
                 16765 
               
               
                 hsa-miR-30b* 
                 87 
                 46 
                 53 
                 77 
                 76 
                 50 
                 39 
               
               
                 hsa-miR-30c 
                 13867 
                 33356 
                 32048 
                 37747 
                 37655 
                 35877 
                 24196 
               
               
                 hsa-miR-30c-1* 
                 54 
                 28 
                 31 
                 50 
                 51 
                 25 
                 26 
               
               
                 hsa-miR-30c-2* 
                 0 
                 367 
                 324 
                 335 
                 330 
                 411 
                 491 
               
               
                 hsa-miR-30d 
                 235117 
                 66258 
                 63436 
                 72267 
                 71041 
                 71729 
                 54966 
               
               
                 hsa-miR-30d* 
                 450 
                 83 
                 84 
                 90 
                 88 
                 83 
                 74 
               
               
                 hsa-miR-30e 
                 238220 
                 47135 
                 46880 
                 52861 
                 55314 
                 52193 
                 14558 
               
               
                 hsa-miR-30e* 
                 11783 
                 6097 
                 5381 
                 6546 
                 6164 
                 6665 
                 3187 
               
               
                 hsa-miR-31 
                 0 
                 776 
                 768 
                 823 
                 692 
                 794 
                 654 
               
               
                 hsa-miR-31* 
                 0 
                 22 
                 31 
                 21 
                 26 
                 31 
                 40 
               
               
                 hsa-miR-3115 
                 2 
                 3 
                 1 
                 2 
                 1 
                 2 
                 2 
               
               
                 hsa-miR-3116 
                 0 
                 0 
                 1 
                 0 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-3117 
                 0 
                 10 
                 7 
                 8 
                 6 
                 6 
                 0 
               
               
                 hsa-miR-3118 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3119 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3120 
                 1 
                 0 
                 0 
                 1 
                 0 
                 2 
                 0 
               
               
                 hsa-miR-3121 
                 4 
                 1 
                 0 
                 0 
                 0 
                 1 
                 1 
               
               
                 hsa-miR-3122 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-3123 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3124 
                 0 
                 3 
                 3 
                 1 
                 3 
                 3 
                 2 
               
               
                 hsa-miR-3125 
                 0 
                 2 
                 3 
                 0 
                 1 
                 4 
                 1 
               
               
                 hsa-miR-3126-3p 
                 0 
                 0 
                 0 
                 2 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3126-5p 
                 0 
                 1 
                 0 
                 0 
                 0 
                 3 
                 0 
               
               
                 hsa-miR-3127 
                 15 
                 5 
                 1 
                 2 
                 4 
                 0 
                 1 
               
               
                 hsa-miR-3128 
                 13 
                 0 
                 4 
                 0 
                 0 
                 4 
                 0 
               
               
                 hsa-miR-3129 
                 0 
                 5 
                 3 
                 8 
                 5 
                 7 
                 14 
               
               
                 hsa-miR-3130-3p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3130-5p 
                 7 
                 2 
                 1 
                 0 
                 1 
                 1 
                 1 
               
               
                 hsa-miR-3131 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3132 
                 0 
                 1 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-3133 
                 5 
                 1 
                 1 
                 2 
                 1 
                 0 
                 2 
               
               
                 hsa-miR-3134 
                 3 
                 1 
                 1 
                 1 
                 0 
                 3 
                 1 
               
               
                 hsa-miR-3135 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3136 
                 8 
                 2 
                 2 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3137 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3138 
                 1 
                 5 
                 3 
                 4 
                 1 
                 0 
                 2 
               
               
                 hsa-miR-3139 
                 1 
                 1 
                 0 
                 0 
                 3 
                 0 
                 0 
               
               
                 hsa-miR-3140 
                 6 
                 2 
                 1 
                 0 
                 3 
                 0 
                 1 
               
               
                 hsa-miR-3141 
                 1 
                 1 
                 1 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3142 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3143 
                 1 
                 1 
                 0 
                 1 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-3144-3p 
                 0 
                 0 
                 0 
                 1 
                 0 
                 1 
                 1 
               
               
                 hsa-miR-3144-5p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 2 
                 1 
               
               
                 hsa-miR-3145 
                 0 
                 0 
                 0 
                 0 
                 3 
                 2 
                 0 
               
               
                 hsa-miR-3146 
                 10 
                 3 
                 1 
                 2 
                 2 
                 6 
                 1 
               
               
                 hsa-miR-3147 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3148 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3149 
                 0 
                 1 
                 2 
                 1 
                 1 
                 2 
                 0 
               
               
                 hsa-miR-3150 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3151 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3152 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3153 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3154 
                 0 
                 7 
                 9 
                 13 
                 5 
                 13 
                 2 
               
               
                 hsa-miR-3155 
                 1 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3156 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3157 
                 1 
                 1 
                 1 
                 1 
                 1 
                 2 
                 2 
               
               
                 hsa-miR-3158 
                 135 
                 3 
                 6 
                 7 
                 10 
                 8 
                 1 
               
               
                 hsa-miR-3159 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3160 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3161 
                 6 
                 0 
                 1 
                 1 
                 0 
                 3 
                 0 
               
               
                 hsa-miR-3162 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3163 
                 0 
                 1 
                 1 
                 1 
                 1 
                 1 
                 1 
               
               
                 hsa-miR-3164 
                 11 
                 3 
                 3 
                 3 
                 7 
                 6 
                 2 
               
               
                 hsa-miR-3165 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3166 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-3167 
                 0 
                 2 
                 0 
                 1 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-3168 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 2 
               
               
                 hsa-miR-3169 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3170 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3171 
                 0 
                 0 
                 1 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3172 
                 22 
                 49 
                 37 
                 44 
                 37 
                 47 
                 188 
               
               
                 hsa-miR-3173 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-3174 
                 10 
                 1 
                 1 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-3175 
                 0 
                 0 
                 0 
                 0 
                 2 
                 0 
                 1 
               
               
                 hsa-miR-3176 
                 14 
                 2 
                 1 
                 5 
                 7 
                 4 
                 1 
               
               
                 hsa-miR-3177 
                 9 
                 3 
                 5 
                 5 
                 4 
                 5 
                 0 
               
               
                 hsa-miR-3178 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3179 
                 3 
                 2 
                 0 
                 0 
                 0 
                 1 
                 1 
               
               
                 hsa-miR-3180-3p 
                 7 
                 1 
                 0 
                 2 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-3180-5p 
                 0 
                 0 
                 1 
                 0 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-3181 
                 2 
                 0 
                 0 
                 1 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3182 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3183 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3184 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3185 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3186-3p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3186-5p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3187 
                 6 
                 3 
                 1 
                 3 
                 0 
                 3 
                 0 
               
               
                 hsa-miR-3188 
                 6 
                 8 
                 10 
                 13 
                 9 
                 7 
                 2 
               
               
                 hsa-miR-3189 
                 0 
                 0 
                 0 
                 2 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3190-3p 
                 3 
                 1 
                 0 
                 1 
                 1 
                 2 
                 1 
               
               
                 hsa-miR-3190-5p 
                 3 
                 1 
                 0 
                 1 
                 1 
                 2 
                 1 
               
               
                 hsa-miR-3191 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3192 
                 1 
                 1 
                 1 
                 2 
                 1 
                 0 
                 2 
               
               
                 hsa-miR-3193 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 1 
               
               
                 hsa-miR-3194 
                 10 
                 3 
                 2 
                 5 
                 2 
                 2 
                 5 
               
               
                 hsa-miR-3195 
                 0 
                 1 
                 0 
                 0 
                 0 
                 1 
                 2 
               
               
                 hsa-miR-3196 
                 0 
                 2 
                 1 
                 0 
                 3 
                 0 
                 2 
               
               
                 hsa-miR-3197 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3198 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-3199 
                 0 
                 6 
                 6 
                 3 
                 2 
                 5 
                 9 
               
               
                 hsa-miR-32 
                 5470 
                 2098 
                 1462 
                 1838 
                 1996 
                 2306 
                 1090 
               
               
                 hsa-miR-32* 
                 68 
                 26 
                 24 
                 24 
                 29 
                 11 
                 13 
               
               
                 hsa-miR-3200 
                 1 
                 37 
                 39 
                 52 
                 34 
                 51 
                 6 
               
               
                 hsa-miR-3201 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-3202 
                 0 
                 1 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-320a 
                 1244 
                 6971 
                 7889 
                 7436 
                 7785 
                 7380 
                 9423 
               
               
                 hsa-miR-320b 
                 51 
                 417 
                 465 
                 390 
                 409 
                 449 
                 2305 
               
               
                 hsa-miR-320c 
                 34 
                 281 
                 247 
                 266 
                 256 
                 296 
                 1932 
               
               
                 hsa-miR-320d 
                 46 
                 314 
                 284 
                 321 
                 258 
                 359 
                 2160 
               
               
                 hsa-miR-320e 
                 6 
                 9 
                 10 
                 13 
                 4 
                 9 
                 58 
               
               
                 hsa-miR-323-3p 
                 0 
                 51 
                 42 
                 56 
                 46 
                 45 
                 11 
               
               
                 hsa-miR-323-5p 
                 0 
                 0 
                 2 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-323b-3p 
                 0 
                 22 
                 12 
                 24 
                 24 
                 24 
                 1 
               
               
                 hsa-miR-323b-5p 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-324-3p 
                 81 
                 88 
                 92 
                 92 
                 102 
                 95 
                 109 
               
               
                 hsa-miR-324-5p 
                 271 
                 177 
                 187 
                 189 
                 174 
                 183 
                 127 
               
               
                 hsa-miR-325 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-326 
                 0 
                 21 
                 21 
                 19 
                 20 
                 16 
                 16 
               
               
                 hsa-miR-328 
                 10 
                 234 
                 256 
                 318 
                 319 
                 224 
                 99 
               
               
                 hsa-miR-329 
                 0 
                 130 
                 98 
                 100 
                 107 
                 108 
                 43 
               
               
                 hsa-miR-330-3p 
                 255 
                 263 
                 217 
                 154 
                 144 
                 284 
                 46 
               
               
                 hsa-miR-330-5p 
                 299 
                 46 
                 33 
                 32 
                 42 
                 44 
                 13 
               
               
                 hsa-miR-331-3p 
                 281 
                 134 
                 178 
                 143 
                 156 
                 135 
                 88 
               
               
                 hsa-miR-331-5p 
                 223 
                 30 
                 24 
                 38 
                 47 
                 26 
                 25 
               
               
                 hsa-miR-335 
                 0 
                 2630 
                 2223 
                 2454 
                 2057 
                 2932 
                 4406 
               
               
                 hsa-miR-335* 
                 1 
                 533 
                 585 
                 687 
                 626 
                 570 
                 505 
               
               
                 hsa-miR-337-3p 
                 0 
                 323 
                 326 
                 405 
                 308 
                 339 
                 200 
               
               
                 hsa-miR-337-5p 
                 0 
                 270 
                 247 
                 249 
                 226 
                 301 
                 111 
               
               
                 hsa-miR-338-3p 
                 0 
                 707 
                 633 
                 705 
                 767 
                 764 
                 49 
               
               
                 hsa-miR-338-5p 
                 0 
                 341 
                 359 
                 464 
                 420 
                 420 
                 23 
               
               
                 hsa-miR-339-3p 
                 2226 
                 606 
                 610 
                 725 
                 721 
                 707 
                 442 
               
               
                 hsa-miR-339-5p 
                 413 
                 186 
                 163 
                 178 
                 203 
                 206 
                 211 
               
               
                 hsa-miR-33a 
                 1634 
                 753 
                 748 
                 945 
                 796 
                 830 
                 95 
               
               
                 hsa-miR-33a* 
                 223 
                 15 
                 12 
                 16 
                 16 
                 14 
                 9 
               
               
                 hsa-miR-33b 
                 385 
                 46 
                 47 
                 67 
                 59 
                 52 
                 58 
               
               
                 hsa-miR-33b* 
                 46 
                 2 
                 1 
                 3 
                 3 
                 3 
                 2 
               
               
                 hsa-miR-340 
                 0 
                 1628 
                 1439 
                 1189 
                 1024 
                 1805 
                 891 
               
               
                 hsa-miR-340* 
                 0 
                 170 
                 162 
                 157 
                 184 
                 161 
                 38 
               
               
                 hsa-miR-342-3p 
                 1703 
                 1869 
                 1713 
                 1975 
                 2067 
                 1940 
                 2239 
               
               
                 hsa-miR-342-5p 
                 185 
                 148 
                 166 
                 164 
                 193 
                 170 
                 329 
               
               
                 hsa-miR-345 
                 4 
                 269 
                 289 
                 274 
                 273 
                 276 
                 235 
               
               
                 hsa-miR-346 
                 0 
                 9 
                 12 
                 12 
                 13 
                 4 
                 3 
               
               
                 hsa-miR-34a 
                 0 
                 1016 
                 1070 
                 1335 
                 1289 
                 1090 
                 1240 
               
               
                 hsa-miR-34a* 
                 0 
                 10 
                 6 
                 8 
                 6 
                 10 
                 9 
               
               
                 hsa-miR-34b 
                 0 
                 93 
                 81 
                 100 
                 104 
                 99 
                 9 
               
               
                 hsa-miR-34b* 
                 0 
                 84 
                 103 
                 103 
                 118 
                 118 
                 6 
               
               
                 hsa-miR-34c-3p 
                 0 
                 128 
                 137 
                 153 
                 174 
                 151 
                 17 
               
               
                 hsa-miR-34c-5p 
                 1 
                 2391 
                 2526 
                 2797 
                 2763 
                 2601 
                 217 
               
               
                 hsa-miR-361-3p 
                 300 
                 272 
                 276 
                 340 
                 317 
                 287 
                 269 
               
               
                 hsa-miR-361-5p 
                 600 
                 1507 
                 1558 
                 1786 
                 1855 
                 1606 
                 1375 
               
               
                 hsa-miR-362-3p 
                 0 
                 49 
                 48 
                 64 
                 65 
                 58 
                 16 
               
               
                 hsa-miR-362-5p 
                 0 
                 193 
                 164 
                 182 
                 181 
                 185 
                 43 
               
               
                 hsa-miR-363 
                 0 
                 1302 
                 1223 
                 1382 
                 1458 
                 1472 
                 157 
               
               
                 hsa-miR-363* 
                 0 
                 0 
                 1 
                 1 
                 3 
                 3 
                 1 
               
               
                 hsa-miR-365 
                 2549 
                 1375 
                 1221 
                 1388 
                 1441 
                 1463 
                 2373 
               
               
                 hsa-miR-365* 
                 0 
                 10 
                 10 
                 6 
                 17 
                 13 
                 62 
               
               
                 hsa-miR-367 
                 0 
                 1 
                 2 
                 3 
                 2 
                 1 
                 0 
               
               
                 hsa-miR-367* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-369-3p 
                 9 
                 577 
                 532 
                 764 
                 701 
                 636 
                 208 
               
               
                 hsa-miR-369-5p 
                 0 
                 100 
                 98 
                 130 
                 119 
                 114 
                 68 
               
               
                 hsa-miR-370 
                 0 
                 61 
                 63 
                 54 
                 60 
                 50 
                 7 
               
               
                 hsa-miR-371-3p 
                 0 
                 3 
                 1 
                 0 
                 3 
                 2 
                 0 
               
               
                 hsa-miR-371-5p 
                 0 
                 10 
                 13 
                 12 
                 15 
                 10 
                 0 
               
               
                 hsa-miR-372 
                 0 
                 34 
                 33 
                 39 
                 40 
                 35 
                 0 
               
               
                 hsa-miR-373 
                 0 
                 33 
                 20 
                 41 
                 20 
                 22 
                 0 
               
               
                 hsa-miR-373* 
                 0 
                 2 
                 0 
                 3 
                 1 
                 3 
                 0 
               
               
                 hsa-miR-374a 
                 1642 
                 4464 
                 5594 
                 8500 
                 9392 
                 5156 
                 2047 
               
               
                 hsa-miR-374a* 
                 23689 
                 5542 
                 5001 
                 6338 
                 6354 
                 6298 
                 3692 
               
               
                 hsa-miR-374b 
                 543 
                 3517 
                 2589 
                 3518 
                 3701 
                 4095 
                 3002 
               
               
                 hsa-miR-374b* 
                 154 
                 105 
                 87 
                 105 
                 123 
                 120 
                 35 
               
               
                 hsa-miR-375 
                 1 
                 1319 
                 1356 
                 1703 
                 1480 
                 1624 
                 638 
               
               
                 hsa-miR-376a 
                 0 
                 87 
                 66 
                 76 
                 89 
                 73 
                 27 
               
               
                 hsa-miR-376a* 
                 0 
                 128 
                 121 
                 166 
                 130 
                 146 
                 53 
               
               
                 hsa-miR-376b 
                 0 
                 103 
                 82 
                 114 
                 112 
                 105 
                 25 
               
               
                 hsa-miR-376c 
                 0 
                 1684 
                 1503 
                 1867 
                 1742 
                 1787 
                 643 
               
               
                 hsa-miR-377 
                 0 
                 558 
                 361 
                 555 
                 569 
                 632 
                 122 
               
               
                 hsa-miR-377* 
                 0 
                 2 
                 3 
                 8 
                 6 
                 6 
                 4 
               
               
                 hsa-miR-378 
                 1201524 
                 154120 
                 139944 
                 167798 
                 163364 
                 166366 
                 118921 
               
               
                 hsa-miR-378* 
                 219 
                 224 
                 214 
                 319 
                 297 
                 265 
                 163 
               
               
                 hsa-miR-378b 
                 3 
                 2 
                 4 
                 4 
                 7 
                 4 
                 4 
               
               
                 hsa-miR-378c 
                 15826 
                 1643 
                 1586 
                 1821 
                 1742 
                 1796 
                 1200 
               
               
                 hsa-miR-379 
                 1 
                 3016 
                 2768 
                 3255 
                 3392 
                 3458 
                 1874 
               
               
                 hsa-miR-379* 
                 0 
                 23 
                 16 
                 26 
                 20 
                 15 
                 4 
               
               
                 hsa-miR-380 
                 0 
                 14 
                 7 
                 20 
                 7 
                 10 
                 5 
               
               
                 hsa-miR-380* 
                 0 
                 30 
                 21 
                 24 
                 22 
                 25 
                 4 
               
               
                 hsa-miR-381 
                 0 
                 1429 
                 1322 
                 1397 
                 1482 
                 1589 
                 443 
               
               
                 hsa-miR-382 
                 0 
                 135 
                 142 
                 129 
                 154 
                 159 
                 79 
               
               
                 hsa-miR-383 
                 0 
                 55 
                 74 
                 56 
                 64 
                 79 
                 29 
               
               
                 hsa-miR-384 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-409-3p 
                 0 
                 92 
                 99 
                 143 
                 114 
                 123 
                 57 
               
               
                 hsa-miR-409-5p 
                 0 
                 27 
                 29 
                 57 
                 36 
                 36 
                 16 
               
               
                 hsa-miR-410 
                 0 
                 94 
                 102 
                 105 
                 91 
                 118 
                 15 
               
               
                 hsa-miR-411 
                 2 
                 823 
                 809 
                 981 
                 1042 
                 911 
                 356 
               
               
                 hsa-miR-411* 
                 0 
                 59 
                 45 
                 40 
                 36 
                 48 
                 10 
               
               
                 hsa-miR-412 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-421 
                 48 
                 185 
                 154 
                 135 
                 135 
                 185 
                 131 
               
               
                 hsa-miR-422a 
                 7 
                 1 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-423-3p 
                 2241 
                 2289 
                 2145 
                 2407 
                 2539 
                 2593 
                 1694 
               
               
                 hsa-miR-423-5p 
                 11168 
                 4665 
                 3912 
                 3296 
                 2517 
                 5015 
                 4426 
               
               
                 hsa-miR-424 
                 1 
                 17513 
                 16557 
                 18944 
                 17115 
                 18702 
                 4393 
               
               
                 hsa-miR-424* 
                 0 
                 166 
                 152 
                 174 
                 159 
                 181 
                 27 
               
               
                 hsa-miR-425 
                 20272 
                 5387 
                 4390 
                 5330 
                 5548 
                 5778 
                 1961 
               
               
                 hsa-miR-425* 
                 463 
                 181 
                 166 
                 241 
                 248 
                 219 
                 224 
               
               
                 hsa-miR-4251 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4252 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4253 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4254 
                 0 
                 0 
                 1 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-4255 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4256 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4257 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4258 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4259 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4260 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4261 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4262 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4263 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4264 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4265 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4266 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4267 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4268 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4269 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4270 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4271 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4272 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4273 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4274 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4275 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4276 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4277 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4278 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4279 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4280 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4281 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4282 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4283 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4284 
                 38 
                 97 
                 85 
                 83 
                 79 
                 110 
                 311 
               
               
                 hsa-miR-4285 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4286 
                 63 
                 95 
                 91 
                 111 
                 101 
                 93 
                 131 
               
               
                 hsa-miR-4287 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4288 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4289 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-429 
                 0 
                 1694 
                 1868 
                 2088 
                 2178 
                 1959 
                 1384 
               
               
                 hsa-miR-4290 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4291 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4292 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4293 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4294 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4295 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4296 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-4297 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4298 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4299 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4300 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4301 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4302 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4303 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4304 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4305 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4306 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4307 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4308 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4309 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-431 
                 0 
                 21 
                 9 
                 10 
                 8 
                 11 
                 2 
               
               
                 hsa-miR-431* 
                 0 
                 13 
                 11 
                 8 
                 11 
                 12 
                 5 
               
               
                 hsa-miR-4310 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4311 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4312 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4313 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4314 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4315 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4316 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4317 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4318 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4319 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-432 
                 0 
                 74 
                 79 
                 71 
                 84 
                 92 
                 71 
               
               
                 hsa-miR-432* 
                 0 
                 2 
                 1 
                 0 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-4320 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4321 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4322 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4323 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-4324 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4325 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4326 
                 24 
                 4 
                 6 
                 3 
                 5 
                 5 
                 2 
               
               
                 hsa-miR-4327 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-4328 
                 0 
                 2 
                 7 
                 7 
                 3 
                 6 
                 0 
               
               
                 hsa-miR-4329 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-433 
                 0 
                 50 
                 32 
                 38 
                 38 
                 45 
                 10 
               
               
                 hsa-miR-4330 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-448 
                 0 
                 1 
                 1 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-449a 
                 10 
                 679 
                 644 
                 797 
                 884 
                 758 
                 13 
               
               
                 hsa-miR-449b 
                 2 
                 108 
                 94 
                 129 
                 111 
                 149 
                 5 
               
               
                 hsa-miR-449b* 
                 0 
                 5 
                 1 
                 1 
                 4 
                 2 
                 0 
               
               
                 hsa-miR-449c 
                 5 
                 110 
                 102 
                 101 
                 101 
                 134 
                 2 
               
               
                 hsa-miR-449c* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-450a 
                 0 
                 876 
                 877 
                 1040 
                 1138 
                 927 
                 261 
               
               
                 hsa-miR-450b-3p 
                 0 
                 3 
                 4 
                 0 
                 8 
                 3 
                 2 
               
               
                 hsa-miR-450b-5p 
                 0 
                 385 
                 341 
                 414 
                 431 
                 420 
                 101 
               
               
                 hsa-miR-451 
                 5 
                 54380 
                 51253 
                 59248 
                 61747 
                 60268 
                 25583 
               
               
                 hsa-miR-452 
                 0 
                 6482 
                 5791 
                 6960 
                 6629 
                 7039 
                 19691 
               
               
                 hsa-miR-452* 
                 0 
                 136 
                 149 
                 150 
                 160 
                 147 
                 389 
               
               
                 hsa-miR-454 
                 939 
                 1874 
                 1335 
                 1717 
                 1577 
                 2044 
                 615 
               
               
                 hsa-miR-454* 
                 6 
                 5 
                 8 
                 14 
                 7 
                 8 
                 3 
               
               
                 hsa-miR-455-3p 
                 0 
                 1300 
                 1114 
                 1459 
                 1285 
                 1398 
                 456 
               
               
                 hsa-miR-455-5p 
                 0 
                 311 
                 241 
                 319 
                 326 
                 303 
                 131 
               
               
                 hsa-miR-466 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-483-3p 
                 0 
                 31 
                 40 
                 31 
                 27 
                 36 
                 11 
               
               
                 hsa-miR-483-5p 
                 0 
                 220 
                 208 
                 223 
                 160 
                 229 
                 156 
               
               
                 hsa-miR-484 
                 367 
                 204 
                 170 
                 193 
                 238 
                 222 
                 116 
               
               
                 hsa-miR-485-3p 
                 0 
                 47 
                 48 
                 40 
                 41 
                 34 
                 7 
               
               
                 hsa-miR-485-5p 
                 0 
                 75 
                 59 
                 61 
                 41 
                 74 
                 18 
               
               
                 hsa-miR-486-3p 
                 6 
                 25 
                 14 
                 28 
                 20 
                 38 
                 5 
               
               
                 hsa-miR-486-5p 
                 52 
                 1057 
                 1088 
                 1112 
                 1126 
                 1079 
                 435 
               
               
                 hsa-miR-487a 
                 0 
                 43 
                 35 
                 55 
                 40 
                 57 
                 14 
               
               
                 hsa-miR-487b 
                 3 
                 213 
                 209 
                 231 
                 266 
                 225 
                 56 
               
               
                 hsa-miR-488 
                 0 
                 21 
                 28 
                 23 
                 40 
                 24 
                 10 
               
               
                 hsa-miR-488* 
                 0 
                 0 
                 0 
                 3 
                 4 
                 2 
                 0 
               
               
                 hsa-miR-489 
                 0 
                 54 
                 46 
                 29 
                 35 
                 45 
                 46 
               
               
                 hsa-miR-490-3p 
                 0 
                 89 
                 93 
                 107 
                 99 
                 105 
                 0 
               
               
                 hsa-miR-490-5p 
                 0 
                 100 
                 74 
                 97 
                 90 
                 82 
                 1 
               
               
                 hsa-miR-491-3p 
                 19 
                 3 
                 8 
                 4 
                 7 
                 7 
                 1 
               
               
                 hsa-miR-491-5p 
                 22 
                 53 
                 48 
                 65 
                 37 
                 61 
                 65 
               
               
                 hsa-miR-492 
                 0 
                 0 
                 0 
                 3 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-493 
                 0 
                 82 
                 80 
                 75 
                 104 
                 94 
                 10 
               
               
                 hsa-miR-493* 
                 0 
                 201 
                 190 
                 248 
                 207 
                 198 
                 23 
               
               
                 hsa-miR-494 
                 4 
                 212 
                 200 
                 227 
                 210 
                 196 
                 167 
               
               
                 hsa-miR-495 
                 0 
                 197 
                 201 
                 231 
                 248 
                 267 
                 62 
               
               
                 hsa-miR-496 
                 0 
                 6 
                 5 
                 7 
                 8 
                 12 
                 1 
               
               
                 hsa-miR-497 
                 1 
                 737 
                 729 
                 811 
                 815 
                 831 
                 1169 
               
               
                 hsa-miR-497* 
                 0 
                 21 
                 25 
                 42 
                 38 
                 26 
                 6 
               
               
                 hsa-miR-498 
                 0 
                 105 
                 68 
                 88 
                 91 
                 94 
                 0 
               
               
                 hsa-miR-499-3p 
                 2 
                 600 
                 758 
                 911 
                 1002 
                 652 
                 12 
               
               
                 hsa-miR-499-5p 
                 7 
                 1417 
                 1293 
                 1309 
                 1223 
                 1611 
                 27 
               
               
                 hsa-miR-500 
                 0 
                 73 
                 86 
                 101 
                 117 
                 107 
                 43 
               
               
                 hsa-miR-500* 
                 0 
                 220 
                 195 
                 231 
                 213 
                 230 
                 109 
               
               
                 hsa-miR-500b 
                 0 
                 61 
                 71 
                 79 
                 91 
                 85 
                 35 
               
               
                 hsa-miR-501-3p 
                 0 
                 48 
                 52 
                 52 
                 45 
                 51 
                 23 
               
               
                 hsa-miR-501-5p 
                 0 
                 49 
                 41 
                 40 
                 41 
                 39 
                 10 
               
               
                 hsa-miR-502-3p 
                 0 
                 139 
                 109 
                 169 
                 166 
                 150 
                 78 
               
               
                 hsa-miR-502-5p 
                 0 
                 20 
                 20 
                 11 
                 14 
                 13 
                 4 
               
               
                 hsa-miR-503 
                 0 
                 358 
                 309 
                 333 
                 280 
                 451 
                 53 
               
               
                 hsa-miR-504 
                 0 
                 49 
                 49 
                 54 
                 50 
                 54 
                 16 
               
               
                 hsa-miR-505 
                 318 
                 238 
                 244 
                 291 
                 277 
                 287 
                 280 
               
               
                 hsa-miR-505* 
                 61 
                 33 
                 43 
                 56 
                 47 
                 39 
                 50 
               
               
                 hsa-miR-506 
                 3 
                 1390 
                 1265 
                 1292 
                 1341 
                 1382 
                 2 
               
               
                 hsa-miR-507 
                 0 
                 77 
                 93 
                 85 
                 111 
                 95 
                 0 
               
               
                 hsa-miR-508-3p 
                 5 
                 5047 
                 4957 
                 5494 
                 5780 
                 5597 
                 15 
               
               
                 hsa-miR-508-5p 
                 0 
                 90 
                 107 
                 74 
                 69 
                 123 
                 0 
               
               
                 hsa-miR-509-3- 
                 0 
                 255 
                 201 
                 176 
                 142 
                 292 
                 1 
               
               
                 5p 
                   
                   
                   
                   
                   
                   
                   
               
               
                 hsa-miR-509-3p 
                 0 
                 466 
                 451 
                 526 
                 568 
                 559 
                 6 
               
               
                 hsa-miR-509-5p 
                 0 
                 619 
                 484 
                 291 
                 225 
                 727 
                 0 
               
               
                 hsa-miR-510 
                 0 
                 296 
                 153 
                 136 
                 80 
                 346 
                 1 
               
               
                 hsa-miR-511 
                 0 
                 12 
                 13 
                 24 
                 20 
                 19 
                 45 
               
               
                 hsa-miR-512-3p 
                 0 
                 442 
                 422 
                 532 
                 537 
                 482 
                 1 
               
               
                 hsa-miR-512-5p 
                 0 
                 178 
                 134 
                 208 
                 221 
                 230 
                 0 
               
               
                 hsa-miR-513a-3p 
                 0 
                 72 
                 46 
                 47 
                 50 
                 79 
                 0 
               
               
                 hsa-miR-513a-5p 
                 0 
                 174 
                 174 
                 149 
                 119 
                 204 
                 1 
               
               
                 hsa-miR-513b 
                 0 
                 81 
                 59 
                 78 
                 65 
                 85 
                 1 
               
               
                 hsa-miR-513c 
                 1 
                 285 
                 270 
                 322 
                 277 
                 313 
                 0 
               
               
                 hsa-miR-514 
                 16 
                 12019 
                 10822 
                 12656 
                 13364 
                 13113 
                 15 
               
               
                 hsa-miR-514b-3p 
                 0 
                 53 
                 61 
                 72 
                 75 
                 62 
                 0 
               
               
                 hsa-miR-514b-5p 
                 0 
                 235 
                 202 
                 167 
                 92 
                 279 
                 0 
               
               
                 hsa-miR-515-3p 
                 0 
                 240 
                 221 
                 307 
                 255 
                 262 
                 2 
               
               
                 hsa-miR-515-5p 
                 0 
                 1542 
                 1362 
                 1693 
                 1677 
                 1619 
                 10 
               
               
                 hsa-miR-516a-3p 
                 0 
                 21 
                 21 
                 19 
                 18 
                 16 
                 0 
               
               
                 hsa-miR-516a-5p 
                 0 
                 4667 
                 4195 
                 4189 
                 4168 
                 5181 
                 12 
               
               
                 hsa-miR-516b 
                 0 
                 2726 
                 2424 
                 2769 
                 2772 
                 3014 
                 7 
               
               
                 hsa-miR-516b* 
                 0 
                 21 
                 21 
                 19 
                 18 
                 16 
                 0 
               
               
                 hsa-miR-517* 
                 0 
                 149 
                 157 
                 193 
                 189 
                 157 
                 0 
               
               
                 hsa-miR-517a 
                 0 
                 2741 
                 2416 
                 2981 
                 3028 
                 2862 
                 20 
               
               
                 hsa-miR-517b 
                 0 
                 2741 
                 2416 
                 2981 
                 3028 
                 2862 
                 20 
               
               
                 hsa-miR-517c 
                 0 
                 698 
                 612 
                 729 
                 771 
                 715 
                 1 
               
               
                 hsa-miR-518a-3p 
                 0 
                 806 
                 768 
                 902 
                 828 
                 789 
                 4 
               
               
                 hsa-miR-518a-5p 
                 0 
                 134 
                 99 
                 157 
                 157 
                 123 
                 1 
               
               
                 hsa-miR-518b 
                 0 
                 1442 
                 1360 
                 1575 
                 1500 
                 1543 
                 14 
               
               
                 hsa-miR-518c 
                 0 
                 3938 
                 2640 
                 3417 
                 3452 
                 4221 
                 16 
               
               
                 hsa-miR-518c* 
                 0 
                 62 
                 43 
                 52 
                 72 
                 69 
                 0 
               
               
                 hsa-miR-518d-3p 
                 0 
                 16 
                 21 
                 34 
                 24 
                 26 
                 0 
               
               
                 hsa-miR-518d-5p 
                 0 
                 119 
                 128 
                 245 
                 271 
                 157 
                 2 
               
               
                 hsa-miR-518e 
                 0 
                 449 
                 466 
                 446 
                 421 
                 467 
                 2 
               
               
                 hsa-miR-518e* 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-518f 
                 0 
                 930 
                 855 
                 925 
                 845 
                 980 
                 7 
               
               
                 hsa-miR-518f* 
                 0 
                 90 
                 102 
                 147 
                 155 
                 120 
                 2 
               
               
                 hsa-miR-519a 
                 0 
                 1316 
                 1191 
                 1350 
                 1357 
                 1415 
                 3 
               
               
                 hsa-miR-519a* 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-519b-3p 
                 0 
                 161 
                 144 
                 167 
                 152 
                 189 
                 4 
               
               
                 hsa-miR-519b-5p 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-519c-3p 
                 0 
                 459 
                 433 
                 475 
                 443 
                 484 
                 8 
               
               
                 hsa-miR-519c-5p 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-519d 
                 0 
                 912 
                 750 
                 964 
                 967 
                 986 
                 7 
               
               
                 hsa-miR-519e 
                 0 
                 21 
                 17 
                 11 
                 20 
                 19 
                 0 
               
               
                 hsa-miR-519e* 
                 0 
                 69 
                 34 
                 47 
                 47 
                 67 
                 0 
               
               
                 hsa-miR-520a-3p 
                 0 
                 181 
                 148 
                 193 
                 179 
                 164 
                 1 
               
               
                 hsa-miR-520a-5p 
                 0 
                 236 
                 209 
                 264 
                 256 
                 269 
                 1 
               
               
                 hsa-miR-520b 
                 0 
                 156 
                 132 
                 181 
                 155 
                 172 
                 4 
               
               
                 hsa-miR-520c-3p 
                 0 
                 156 
                 132 
                 181 
                 155 
                 172 
                 4 
               
               
                 hsa-miR-520c-5p 
                 0 
                 119 
                 128 
                 245 
                 271 
                 157 
                 2 
               
               
                 hsa-miR-520d-3p 
                 0 
                 108 
                 134 
                 139 
                 131 
                 134 
                 0 
               
               
                 hsa-miR-520d-5p 
                 0 
                 88 
                 60 
                 98 
                 75 
                 92 
                 1 
               
               
                 hsa-miR-520e 
                 0 
                 19 
                 15 
                 20 
                 17 
                 15 
                 0 
               
               
                 hsa-miR-520f 
                 0 
                 303 
                 275 
                 314 
                 321 
                 332 
                 17 
               
               
                 hsa-miR-520g 
                 0 
                 696 
                 730 
                 941 
                 899 
                 809 
                 12 
               
               
                 hsa-miR-520h 
                 0 
                 945 
                 985 
                 1293 
                 1214 
                 1076 
                 19 
               
               
                 hsa-miR-521 
                 0 
                 212 
                 137 
                 220 
                 201 
                 225 
                 1 
               
               
                 hsa-miR-522 
                 0 
                 351 
                 323 
                 341 
                 381 
                 370 
                 1 
               
               
                 hsa-miR-522* 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-523 
                 0 
                 1184 
                 1243 
                 1474 
                 1434 
                 1261 
                 7 
               
               
                 hsa-miR-523* 
                 0 
                 1853 
                 1674 
                 2382 
                 2278 
                 2063 
                 26 
               
               
                 hsa-miR-524-3p 
                 0 
                 147 
                 112 
                 132 
                 104 
                 176 
                 2 
               
               
                 hsa-miR-524-5p 
                 0 
                 152 
                 173 
                 179 
                 197 
                 188 
                 6 
               
               
                 hsa-miR-525-3p 
                 0 
                 571 
                 547 
                 692 
                 584 
                 529 
                 1 
               
               
                 hsa-miR-525-5p 
                 0 
                 368 
                 353 
                 400 
                 383 
                 384 
                 3 
               
               
                 hsa-miR-526a 
                 0 
                 119 
                 128 
                 245 
                 271 
                 157 
                 2 
               
               
                 hsa-miR-526b 
                 0 
                 602 
                 491 
                 683 
                 564 
                 599 
                 2 
               
               
                 hsa-miR-526b* 
                 0 
                 115 
                 115 
                 131 
                 123 
                 145 
                 2 
               
               
                 hsa-miR-527 
                 0 
                 134 
                 99 
                 157 
                 157 
                 123 
                 1 
               
               
                 hsa-miR-532-3p 
                 0 
                 297 
                 291 
                 361 
                 366 
                 346 
                 238 
               
               
                 hsa-miR-532-5p 
                 0 
                 1094 
                 973 
                 1063 
                 1106 
                 1140 
                 451 
               
               
                 hsa-miR-539 
                 0 
                 77 
                 100 
                 120 
                 123 
                 94 
                 34 
               
               
                 hsa-miR-541 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-541* 
                 1 
                 0 
                 0 
                 0 
                 1 
                 2 
                 0 
               
               
                 hsa-miR-542-3p 
                 5 
                 2302 
                 2186 
                 2577 
                 2608 
                 2393 
                 594 
               
               
                 hsa-miR-542-5p 
                 0 
                 244 
                 264 
                 263 
                 260 
                 260 
                 72 
               
               
                 hsa-miR-543 
                 0 
                 31 
                 47 
                 34 
                 41 
                 30 
                 6 
               
               
                 hsa-miR-544 
                 0 
                 1 
                 2 
                 5 
                 4 
                 5 
                 1 
               
               
                 hsa-miR-544b 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-545 
                 15 
                 1 
                 6 
                 7 
                 7 
                 14 
                 2 
               
               
                 hsa-miR-545* 
                 16 
                 3 
                 12 
                 11 
                 11 
                 7 
                 11 
               
               
                 hsa-miR-548a-3p 
                 0 
                 8 
                 7 
                 13 
                 12 
                 8 
                 0 
               
               
                 hsa-miR-548a-5p 
                 0 
                 2 
                 0 
                 1 
                 2 
                 1 
                 1 
               
               
                 hsa-miR-548b-3p 
                 0 
                 7 
                 10 
                 7 
                 20 
                 8 
                 12 
               
               
                 hsa-miR-548b-5p 
                 0 
                 0 
                 1 
                 2 
                 5 
                 8 
                 3 
               
               
                 hsa-miR-548c-3p 
                 9 
                 0 
                 1 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-548c-5p 
                 6 
                 20 
                 23 
                 28 
                 29 
                 24 
                 9 
               
               
                 hsa-miR-548d-3p 
                 13 
                 0 
                 5 
                 5 
                 3 
                 3 
                 2 
               
               
                 hsa-miR-548d-5p 
                 37 
                 23 
                 30 
                 45 
                 45 
                 32 
                 6 
               
               
                 hsa-miR-548e 
                 258 
                 30 
                 32 
                 18 
                 17 
                 41 
                 6 
               
               
                 hsa-miR-548f 
                 109 
                 4 
                 4 
                 7 
                 10 
                 5 
                 2 
               
               
                 hsa-miR-548g 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-548h 
                 0 
                 0 
                 0 
                 2 
                 3 
                 1 
                 0 
               
               
                 hsa-miR-548i 
                 0 
                 7 
                 8 
                 12 
                 10 
                 12 
                 1 
               
               
                 hsa-miR-548j 
                 63 
                 15 
                 18 
                 14 
                 26 
                 10 
                 7 
               
               
                 hsa-miR-548k 
                 20 
                 16 
                 7 
                 11 
                 4 
                 18 
                 6 
               
               
                 hsa-miR-548l 
                 9 
                 5 
                 2 
                 4 
                 2 
                 4 
                 0 
               
               
                 hsa-miR-548m 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-548n 
                 15 
                 4 
                 3 
                 4 
                 7 
                 4 
                 0 
               
               
                 hsa-miR-548o 
                 60 
                 12 
                 6 
                 11 
                 8 
                 12 
                 9 
               
               
                 hsa-miR-548p 
                 1 
                 0 
                 0 
                 1 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-548q 
                 2 
                 4 
                 9 
                 6 
                 5 
                 4 
                 4 
               
               
                 hsa-miR-548s 
                 0 
                 0 
                 0 
                 2 
                 1 
                 1 
                 1 
               
               
                 hsa-miR-548t 
                 3 
                 0 
                 0 
                 1 
                 3 
                 4 
                 1 
               
               
                 hsa-miR-548u 
                 1 
                 0 
                 0 
                 1 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-548v 
                 0 
                 1 
                 1 
                 2 
                 2 
                 2 
                 4 
               
               
                 hsa-miR-548w 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-548x 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-549 
                 0 
                 4 
                 1 
                 0 
                 2 
                 5 
                 0 
               
               
                 hsa-miR-550 
                 0 
                 10 
                 16 
                 21 
                 12 
                 15 
                 11 
               
               
                 hsa-miR-550* 
                 3 
                 13 
                 11 
                 7 
                 6 
                 10 
                 7 
               
               
                 hsa-miR-551a 
                 2 
                 4 
                 0 
                 4 
                 1 
                 4 
                 2 
               
               
                 hsa-miR-551b 
                 0 
                 10 
                 6 
                 10 
                 17 
                 11 
                 34 
               
               
                 hsa-miR-551b* 
                 0 
                 1 
                 1 
                 2 
                 2 
                 2 
                 0 
               
               
                 hsa-miR-552 
                 2 
                 4 
                 2 
                 4 
                 2 
                 2 
                 0 
               
               
                 hsa-miR-553 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-554 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-555 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-556-3p 
                 0 
                 0 
                 1 
                 1 
                 3 
                 1 
                 3 
               
               
                 hsa-miR-556-5p 
                 0 
                 17 
                 9 
                 13 
                 9 
                 6 
                 9 
               
               
                 hsa-miR-557 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-558 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-559 
                 0 
                 1 
                 0 
                 2 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-561 
                 0 
                 2 
                 1 
                 2 
                 2 
                 2 
                 0 
               
               
                 hsa-miR-562 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-563 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-564 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-566 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-567 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-568 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-569 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-570 
                 8 
                 10 
                 15 
                 9 
                 10 
                 11 
                 15 
               
               
                 hsa-miR-571 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-572 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-573 
                 198 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-574-3p 
                 0 
                 729 
                 814 
                 1021 
                 1042 
                 847 
                 702 
               
               
                 hsa-miR-574-5p 
                 0 
                 133 
                 123 
                 136 
                 124 
                 121 
                 169 
               
               
                 hsa-miR-575 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-576-3p 
                 125 
                 34 
                 55 
                 58 
                 61 
                 43 
                 31 
               
               
                 hsa-miR-576-5p 
                 75 
                 120 
                 94 
                 113 
                 107 
                 136 
                 44 
               
               
                 hsa-miR-577 
                 1234 
                 169 
                 154 
                 215 
                 178 
                 204 
                 8 
               
               
                 hsa-miR-578 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-579 
                 11 
                 6 
                 6 
                 5 
                 7 
                 7 
                 2 
               
               
                 hsa-miR-580 
                 55 
                 9 
                 7 
                 8 
                 10 
                 10 
                 0 
               
               
                 hsa-miR-581 
                 2 
                 1 
                 1 
                 2 
                 1 
                 0 
                 5 
               
               
                 hsa-miR-582-3p 
                 1484 
                 121 
                 118 
                 137 
                 145 
                 135 
                 26 
               
               
                 hsa-miR-582-5p 
                 592 
                 149 
                 183 
                 177 
                 151 
                 163 
                 35 
               
               
                 hsa-miR-583 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-584 
                 0 
                 108 
                 96 
                 109 
                 111 
                 104 
                 22 
               
               
                 hsa-miR-585 
                 0 
                 39 
                 24 
                 30 
                 46 
                 31 
                 12 
               
               
                 hsa-miR-586 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-587 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-588 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-589 
                 635 
                 46 
                 59 
                 54 
                 62 
                 71 
                 49 
               
               
                 hsa-miR-589* 
                 85 
                 8 
                 5 
                 8 
                 5 
                 3 
                 6 
               
               
                 hsa-miR-590-3p 
                 650 
                 373 
                 395 
                 381 
                 399 
                 415 
                 178 
               
               
                 hsa-miR-590-5p 
                 333 
                 859 
                 660 
                 849 
                 758 
                 905 
                 275 
               
               
                 hsa-miR-591 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-592 
                 1 
                 20 
                 14 
                 22 
                 26 
                 15 
                 0 
               
               
                 hsa-miR-593 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-593* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-595 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-596 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-597 
                 2 
                 5 
                 3 
                 5 
                 2 
                 2 
                 2 
               
               
                 hsa-miR-598 
                 2107 
                 680 
                 705 
                 799 
                 758 
                 750 
                 133 
               
               
                 hsa-miR-599 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-600 
                 0 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-601 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-602 
                 0 
                 1 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-603 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-604 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-605 
                 0 
                 0 
                 0 
                 1 
                 4 
                 1 
                 0 
               
               
                 hsa-miR-606 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-607 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-608 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-609 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-610 
                 1 
                 0 
                 2 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-611 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-612 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-613 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-614 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-615-3p 
                 0 
                 16 
                 26 
                 27 
                 35 
                 28 
                 45 
               
               
                 hsa-miR-615-5p 
                 0 
                 0 
                 0 
                 2 
                 2 
                 0 
                 0 
               
               
                 hsa-miR-616 
                 7 
                 3 
                 4 
                 3 
                 2 
                 5 
                 3 
               
               
                 hsa-miR-616* 
                 4 
                 23 
                 18 
                 20 
                 26 
                 30 
                 8 
               
               
                 hsa-miR-617 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-618 
                 0 
                 26 
                 25 
                 28 
                 30 
                 28 
                 31 
               
               
                 hsa-miR-619 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-620 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-621 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-622 
                 0 
                 1 
                 1 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-623 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-624 
                 0 
                 3 
                 6 
                 2 
                 6 
                 4 
                 0 
               
               
                 hsa-miR-624* 
                 32 
                 14 
                 7 
                 9 
                 7 
                 9 
                 7 
               
               
                 hsa-miR-625 
                 76 
                 60 
                 63 
                 73 
                 62 
                 65 
                 64 
               
               
                 hsa-miR-625* 
                 255 
                 116 
                 72 
                 119 
                 100 
                 94 
                 58 
               
               
                 hsa-miR-626 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-627 
                 703 
                 78 
                 62 
                 81 
                 67 
                 79 
                 68 
               
               
                 hsa-miR-628-3p 
                 11 
                 122 
                 116 
                 117 
                 87 
                 144 
                 47 
               
               
                 hsa-miR-628-5p 
                 132 
                 440 
                 405 
                 491 
                 506 
                 526 
                 129 
               
               
                 hsa-miR-629 
                 516 
                 36 
                 40 
                 43 
                 53 
                 46 
                 78 
               
               
                 hsa-miR-629* 
                 67 
                 10 
                 12 
                 10 
                 15 
                 17 
                 9 
               
               
                 hsa-miR-630 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-631 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-632 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-633 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-634 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-635 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-636 
                 1 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-637 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-638 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-639 
                 1 
                 0 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-640 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-641 
                 10 
                 10 
                 9 
                 7 
                 3 
                 13 
                 3 
               
               
                 hsa-miR-642 
                 1 
                 6 
                 3 
                 8 
                 5 
                 5 
                 4 
               
               
                 hsa-miR-643 
                 12 
                 3 
                 2 
                 7 
                 10 
                 5 
                 6 
               
               
                 hsa-miR-644 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-645 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-646 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-647 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-648 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-649 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-650 
                 0 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-651 
                 372 
                 55 
                 60 
                 55 
                 54 
                 65 
                 42 
               
               
                 hsa-miR-652 
                 160 
                 330 
                 330 
                 316 
                 329 
                 325 
                 437 
               
               
                 hsa-miR-653 
                 0 
                 43 
                 32 
                 37 
                 53 
                 39 
                 44 
               
               
                 hsa-miR-654-3p 
                 0 
                 135 
                 128 
                 182 
                 161 
                 161 
                 102 
               
               
                 hsa-miR-654-5p 
                 0 
                 5 
                 13 
                 12 
                 12 
                 12 
                 5 
               
               
                 hsa-miR-655 
                 0 
                 137 
                 128 
                 185 
                 178 
                 183 
                 72 
               
               
                 hsa-miR-656 
                 0 
                 13 
                 19 
                 27 
                 16 
                 21 
                 18 
               
               
                 hsa-miR-657 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-658 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-659 
                 2 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-660 
                 0 
                 271 
                 259 
                 280 
                 290 
                 334 
                 171 
               
               
                 hsa-miR-661 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-662 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-663 
                 0 
                 2 
                 2 
                 5 
                 3 
                 4 
                 17 
               
               
                 hsa-miR-663b 
                 10 
                 4 
                 1 
                 6 
                 2 
                 1 
                 1 
               
               
                 hsa-miR-664 
                 483 
                 198 
                 174 
                 218 
                 213 
                 206 
                 152 
               
               
                 hsa-miR-664* 
                 98 
                 136 
                 127 
                 184 
                 177 
                 174 
                 200 
               
               
                 hsa-miR-665 
                 0 
                 4 
                 7 
                 5 
                 6 
                 2 
                 7 
               
               
                 hsa-miR-668 
                 0 
                 1 
                 3 
                 2 
                 6 
                 5 
                 0 
               
               
                 hsa-miR-670 
                 0 
                 1 
                 0 
                 0 
                 3 
                 0 
                 0 
               
               
                 hsa-miR-671-3p 
                 25 
                 6 
                 4 
                 7 
                 8 
                 6 
                 3 
               
               
                 hsa-miR-671-5p 
                 529 
                 151 
                 163 
                 167 
                 155 
                 149 
                 183 
               
               
                 hsa-miR-675 
                 0 
                 8 
                 7 
                 11 
                 2 
                 7 
                 5 
               
               
                 hsa-miR-675* 
                 0 
                 255 
                 247 
                 323 
                 283 
                 247 
                 115 
               
               
                 hsa-miR-7 
                 3569 
                 3622 
                 2924 
                 2472 
                 1896 
                 4096 
                 257 
               
               
                 hsa-miR-708 
                 0 
                 1228 
                 1437 
                 1479 
                 1584 
                 1298 
                 1056 
               
               
                 hsa-miR-708* 
                 0 
                 68 
                 48 
                 79 
                 76 
                 72 
                 35 
               
               
                 hsa-miR-7-1* 
                 295 
                 64 
                 57 
                 58 
                 57 
                 35 
                 22 
               
               
                 hsa-miR-711 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-718 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-7-2* 
                 0 
                 12 
                 5 
                 9 
                 6 
                 7 
                 4 
               
               
                 hsa-miR-720 
                 154 
                 188 
                 204 
                 273 
                 188 
                 188 
                 30 
               
               
                 hsa-miR-744 
                 862 
                 707 
                 698 
                 750 
                 701 
                 733 
                 628 
               
               
                 hsa-miR-744* 
                 20 
                 27 
                 21 
                 32 
                 24 
                 15 
                 11 
               
               
                 hsa-miR-758 
                 0 
                 5 
                 7 
                 7 
                 8 
                 6 
                 2 
               
               
                 hsa-miR-759 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-760 
                 1 
                 5 
                 9 
                 4 
                 6 
                 6 
                 10 
               
               
                 hsa-miR-761 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-762 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-764 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-765 
                 0 
                 3 
                 1 
                 3 
                 3 
                 6 
                 1 
               
               
                 hsa-miR-766 
                 229 
                 87 
                 73 
                 93 
                 89 
                 110 
                 29 
               
               
                 hsa-miR-767-3p 
                 0 
                 2 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-767-5p 
                 0 
                 3 
                 10 
                 7 
                 11 
                 5 
                 0 
               
               
                 hsa-miR-769-3p 
                 91 
                 5 
                 6 
                 10 
                 8 
                 6 
                 3 
               
               
                 hsa-miR-769-5p 
                 4023 
                 531 
                 514 
                 547 
                 553 
                 547 
                 464 
               
               
                 hsa-miR-770-5p 
                 0 
                 1 
                 4 
                 1 
                 3 
                 7 
                 0 
               
               
                 hsa-miR-802 
                 0 
                 46 
                 50 
                 53 
                 51 
                 52 
                 0 
               
               
                 hsa-miR-873 
                 0 
                 19 
                 19 
                 17 
                 11 
                 26 
                 2 
               
               
                 hsa-miR-874 
                 10 
                 234 
                 230 
                 307 
                 286 
                 254 
                 193 
               
               
                 hsa-miR-875-3p 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-875-5p 
                 0 
                 5 
                 1 
                 0 
                 2 
                 0 
                 1 
               
               
                 hsa-miR-876-3p 
                 0 
                 1 
                 0 
                 1 
                 0 
                 4 
                 0 
               
               
                 hsa-miR-876-5p 
                 0 
                 3 
                 1 
                 6 
                 2 
                 1 
                 1 
               
               
                 hsa-miR-877 
                 846 
                 133 
                 104 
                 75 
                 55 
                 151 
                 96 
               
               
                 hsa-miR-877* 
                 2 
                 1 
                 0 
                 0 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-885-3p 
                 0 
                 14 
                 12 
                 8 
                 8 
                 6 
                 1 
               
               
                 hsa-miR-885-5p 
                 0 
                 89 
                 94 
                 66 
                 93 
                 84 
                 2 
               
               
                 hsa-miR-886-3p 
                 69 
                 5 
                 12 
                 12 
                 8 
                 6 
                 8 
               
               
                 hsa-miR-886-5p 
                 15314 
                 661 
                 618 
                 705 
                 721 
                 710 
                 1271 
               
               
                 hsa-miR-887 
                 0 
                 108 
                 132 
                 128 
                 127 
                 131 
                 116 
               
               
                 hsa-miR-888 
                 0 
                 55 
                 49 
                 58 
                 75 
                 84 
                 0 
               
               
                 hsa-miR-888* 
                 0 
                 0 
                 1 
                 2 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-889 
                 0 
                 211 
                 180 
                 273 
                 254 
                 234 
                 57 
               
               
                 hsa-miR-890 
                 0 
                 4 
                 1 
                 5 
                 6 
                 11 
                 0 
               
               
                 hsa-miR-891a 
                 1 
                 358 
                 311 
                 363 
                 390 
                 384 
                 4 
               
               
                 hsa-miR-891b 
                 0 
                 14 
                 10 
                 11 
                 8 
                 4 
                 0 
               
               
                 hsa-miR-892a 
                 0 
                 7 
                 4 
                 10 
                 7 
                 6 
                 0 
               
               
                 hsa-miR-892b 
                 0 
                 5 
                 5 
                 5 
                 2 
                 6 
                 0 
               
               
                 hsa-miR-9 
                 13310 
                 10506 
                 9814 
                 11411 
                 11015 
                 11489 
                 233 
               
               
                 hsa-miR-9* 
                 1880 
                 2040 
                 2327 
                 2671 
                 2670 
                 2212 
                 75 
               
               
                 hsa-miR-920 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-921 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-922 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-924 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-92a 
                 27036 
                 4490 
                 4235 
                 4907 
                 4803 
                 4907 
                 3961 
               
               
                 hsa-miR-92a-1* 
                 328 
                 61 
                 43 
                 71 
                 61 
                 47 
                 42 
               
               
                 hsa-miR-92a-2* 
                 0 
                 0 
                 2 
                 1 
                 1 
                 0 
                 0 
               
               
                 hsa-miR-92b 
                 65 
                 508 
                 522 
                 615 
                 602 
                 591 
                 314 
               
               
                 hsa-miR-92b* 
                 4 
                 25 
                 17 
                 15 
                 13 
                 25 
                 9 
               
               
                 hsa-miR-93 
                 29354 
                 5197 
                 4866 
                 5765 
                 5546 
                 5717 
                 4574 
               
               
                 hsa-miR-93* 
                 25 
                 39 
                 37 
                 39 
                 37 
                 38 
                 71 
               
               
                 hsa-miR-933 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
                 0 
               
               
                 hsa-miR-934 
                 0 
                 101 
                 149 
                 198 
                 206 
                 145 
                 49 
               
               
                 hsa-miR-935 
                 1 
                 74 
                 104 
                 125 
                 114 
                 94 
                 9 
               
               
                 hsa-miR-936 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-937 
                 1 
                 0 
                 2 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-938 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-939 
                 8 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 hsa-miR-940 
                 7 
                 4 
                 7 
                 8 
                 5 
                 10 
                 4 
               
               
                 hsa-miR-941 
                 244 
                 145 
                 116 
                 136 
                 116 
                 173 
                 43 
               
               
                 hsa-miR-942 
                 75 
                 8 
                 12 
                 12 
                 11 
                 8 
                 3 
               
               
                 hsa-miR-943 
                 1 
                 0 
                 0 
                 0 
                 0 
                 0 
                 2 
               
               
                 hsa-miR-944 
                 1109 
                 143 
                 143 
                 144 
                 158 
                 164 
                 26 
               
               
                 hsa-miR-95 
                 57 
                 3409 
                 3489 
                 3620 
                 3782 
                 3901 
                 720 
               
               
                 hsa-miR-96 
                 783 
                 146 
                 122 
                 146 
                 138 
                 173 
                 681 
               
               
                 hsa-miR-96* 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
                 1 
               
               
                 hsa-miR-98 
                 1602 
                 2924 
                 2956 
                 3366 
                 3559 
                 3153 
                 2291 
               
               
                 hsa-miR-99a 
                 692 
                 23127 
                 23513 
                 27764 
                 27299 
                 25367 
                 12696 
               
               
                 hsa-miR-99a* 
                 42 
                 116 
                 97 
                 118 
                 115 
                 112 
                 68 
               
               
                 hsa-miR-99b 
                 9 
                 16328 
                 14746 
                 17477 
                 16934 
                 17389 
                 6543 
               
               
                 hsa-miR-99b* 
                 0 
                 52 
                 58 
                 73 
                 42 
                 55 
                 51 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
               
             
               
               
               
             
           
               
                   
                 TABLE 11 
               
               
                   
                   
               
               
                   
                 miRNA 
                 Read count-all 
               
               
                   
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 hsa-let-7a 
                 3263253 
               
               
                   
                 hsa-let-7a* 
                 2627 
               
               
                   
                 hsa-let-7a-2* 
                 130 
               
               
                   
                 hsa-let-7b 
                 629946 
               
               
                   
                 hsa-let-7b* 
                 2206 
               
               
                   
                 hsa-let-7c 
                 586231 
               
               
                   
                 hsa-let-7c* 
                 41 
               
               
                   
                 hsa-let-7d 
                 80917 
               
               
                   
                 hsa-let-7d* 
                 13259 
               
               
                   
                 hsa-let-7e 
                 115027 
               
               
                   
                 hsa-let-7e* 
                 774 
               
               
                   
                 hsa-let-7f 
                 3480770 
               
               
                   
                 hsa-let-7f-1* 
                 344 
               
               
                   
                 hsa-let-7f-2* 
                 144 
               
               
                   
                 hsa-let-7g 
                 729933 
               
               
                   
                 hsa-let-7g* 
                 2239 
               
               
                   
                 hsa-let-7i 
                 123591 
               
               
                   
                 hsa-let-7i* 
                 3761 
               
               
                   
                 hsa-miR-1 
                 4827651 
               
               
                   
                 hsa-miR-100 
                 371538 
               
               
                   
                 hsa-miR-100* 
                 359 
               
               
                   
                 hsa-miR-101 
                 1018648 
               
               
                   
                 hsa-miR-101* 
                 4418 
               
               
                   
                 hsa-miR-103 
                 608126 
               
               
                   
                 hsa-miR-103-2* 
                 301 
               
               
                   
                 hsa-miR-103-as 
                 0 
               
               
                   
                 hsa-miR-105 
                 154 
               
               
                   
                 hsa-miR-105* 
                 6 
               
               
                   
                 hsa-miR-106a 
                 17036 
               
               
                   
                 hsa-miR-106a* 
                 87 
               
               
                   
                 hsa-miR-106b 
                 76043 
               
               
                   
                 hsa-miR-106b* 
                 3665 
               
               
                   
                 hsa-miR-107 
                 5450 
               
               
                   
                 hsa-miR-10a 
                 411798 
               
               
                   
                 hsa-miR-10a* 
                 1392 
               
               
                   
                 hsa-miR-10b 
                 671361 
               
               
                   
                 hsa-miR-10b* 
                 4311 
               
               
                   
                 hsa-miR-1178 
                 0 
               
               
                   
                 hsa-miR-1179 
                 977 
               
               
                   
                 hsa-miR-1180 
                 351 
               
               
                   
                 hsa-miR-1181 
                 1 
               
               
                   
                 hsa-miR-1182 
                 0 
               
               
                   
                 hsa-miR-1183 
                 0 
               
               
                   
                 hsa-miR-1184 
                 0 
               
               
                   
                 hsa-miR-1185 
                 503 
               
               
                   
                 hsa-miR-1193 
                 3 
               
               
                   
                 hsa-miR-1197 
                 20 
               
               
                   
                 hsa-miR-1200 
                 0 
               
               
                   
                 hsa-miR-1201 
                 1283 
               
               
                   
                 hsa-miR-1202 
                 0 
               
               
                   
                 hsa-miR-1203 
                 0 
               
               
                   
                 hsa-miR-1204 
                 0 
               
               
                   
                 hsa-miR-1205 
                 0 
               
               
                   
                 hsa-miR-1206 
                 0 
               
               
                   
                 hsa-miR-1207-3p 
                 0 
               
               
                   
                 hsa-miR-1207-5p 
                 0 
               
               
                   
                 hsa-miR-1208 
                 0 
               
               
                   
                 hsa-miR-122 
                 71506 
               
               
                   
                 hsa-miR-122* 
                 881 
               
               
                   
                 hsa-miR-1224-3p 
                 8 
               
               
                   
                 hsa-miR-1224-5p 
                 212 
               
               
                   
                 hsa-miR-1225-3p 
                 2 
               
               
                   
                 hsa-miR-1225-5p 
                 12 
               
               
                   
                 hsa-miR-1226 
                 35 
               
               
                   
                 hsa-miR-1226* 
                 11 
               
               
                   
                 hsa-miR-1227 
                 0 
               
               
                   
                 hsa-miR-1228 
                 10 
               
               
                   
                 hsa-miR-1228* 
                 9 
               
               
                   
                 hsa-miR-1229 
                 15 
               
               
                   
                 hsa-miR-1231 
                 9 
               
               
                   
                 hsa-miR-1233 
                 5 
               
               
                   
                 hsa-miR-1234 
                 7 
               
               
                   
                 hsa-miR-1236 
                 0 
               
               
                   
                 hsa-miR-1237 
                 0 
               
               
                   
                 hsa-miR-1238 
                 1 
               
               
                   
                 hsa-miR-124 
                 14855 
               
               
                   
                 hsa-miR-124* 
                 55 
               
               
                   
                 hsa-miR-1243 
                 28 
               
               
                   
                 hsa-miR-1244 
                 43 
               
               
                   
                 hsa-miR-1245 
                 23 
               
               
                   
                 hsa-miR-1246 
                 163980 
               
               
                   
                 hsa-miR-1247 
                 1190 
               
               
                   
                 hsa-miR-1248 
                 266 
               
               
                   
                 hsa-miR-1249 
                 348 
               
               
                   
                 hsa-miR-1250 
                 22 
               
               
                   
                 hsa-miR-1251 
                 956 
               
               
                   
                 hsa-miR-1252 
                 16 
               
               
                   
                 hsa-miR-1253 
                 0 
               
               
                   
                 hsa-miR-1254 
                 114 
               
               
                   
                 hsa-miR-1255a 
                 204 
               
               
                   
                 hsa-miR-1255b 
                 59 
               
               
                   
                 hsa-miR-1256 
                 17 
               
               
                   
                 hsa-miR-1257 
                 29 
               
               
                   
                 hsa-miR-1258 
                 38 
               
               
                   
                 hsa-miR-1259 
                 807 
               
               
                   
                 hsa-miR-125a-3p 
                 820 
               
               
                   
                 hsa-miR-125a-5p 
                 197714 
               
               
                   
                 hsa-miR-125b 
                 407709 
               
               
                   
                 hsa-miR-125b-1* 
                 966 
               
               
                   
                 hsa-miR-125b-2* 
                 18552 
               
               
                   
                 hsa-miR-126 
                 2107272 
               
               
                   
                 hsa-miR-126* 
                 279706 
               
               
                   
                 hsa-miR-1260 
                 16 
               
               
                   
                 hsa-miR-1260b 
                 216 
               
               
                   
                 hsa-miR-1261 
                 0 
               
               
                   
                 hsa-miR-1262 
                 184 
               
               
                   
                 hsa-miR-1263 
                 2 
               
               
                   
                 hsa-miR-1264 
                 13 
               
               
                   
                 hsa-miR-1265 
                 5 
               
               
                   
                 hsa-miR-1266 
                 61 
               
               
                   
                 hsa-miR-1267 
                 2 
               
               
                   
                 hsa-miR-1268 
                 788 
               
               
                   
                 hsa-miR-1269 
                 157 
               
               
                   
                 hsa-miR-1270 
                 1259 
               
               
                   
                 hsa-miR-1271 
                 576 
               
               
                   
                 hsa-miR-1272 
                 3 
               
               
                   
                 hsa-miR-1273 
                 0 
               
               
                   
                 hsa-miR-1273c 
                 91 
               
               
                   
                 hsa-miR-1273d 
                 9 
               
               
                   
                 hsa-miR-127-3p 
                 27435 
               
               
                   
                 hsa-miR-1274a 
                 15 
               
               
                   
                 hsa-miR-1274b 
                 617 
               
               
                   
                 hsa-miR-1275 
                 746 
               
               
                   
                 hsa-miR-127-5p 
                 4243 
               
               
                   
                 hsa-miR-1276 
                 36 
               
               
                   
                 hsa-miR-1277 
                 467 
               
               
                   
                 hsa-miR-1278 
                 34 
               
               
                   
                 hsa-miR-1279 
                 0 
               
               
                   
                 hsa-miR-128 
                 28463 
               
               
                   
                 hsa-miR-1280 
                 75 
               
               
                   
                 hsa-miR-1281 
                 0 
               
               
                   
                 hsa-miR-1282 
                 0 
               
               
                   
                 hsa-miR-1283 
                 3052 
               
               
                   
                 hsa-miR-1284 
                 12 
               
               
                   
                 hsa-miR-1285 
                 568 
               
               
                   
                 hsa-miR-1286 
                 6 
               
               
                   
                 hsa-miR-1287 
                 415 
               
               
                   
                 hsa-miR-1288 
                 3 
               
               
                   
                 hsa-miR-1289 
                 1 
               
               
                   
                 hsa-miR-129* 
                 332 
               
               
                   
                 hsa-miR-1290 
                 6 
               
               
                   
                 hsa-miR-1291 
                 364 
               
               
                   
                 hsa-miR-1292 
                 518 
               
               
                   
                 hsa-miR-1293 
                 2 
               
               
                   
                 hsa-miR-129-3p 
                 1131 
               
               
                   
                 hsa-miR-1294 
                 41 
               
               
                   
                 hsa-miR-1295 
                 27 
               
               
                   
                 hsa-miR-129-5p 
                 4027 
               
               
                   
                 hsa-miR-1296 
                 785 
               
               
                   
                 hsa-miR-1297 
                 0 
               
               
                   
                 hsa-miR-1298 
                 246 
               
               
                   
                 hsa-miR-1299 
                 935 
               
               
                   
                 hsa-miR-1301 
                 608 
               
               
                   
                 hsa-miR-1302 
                 1 
               
               
                   
                 hsa-miR-1303 
                 133 
               
               
                   
                 hsa-miR-1304 
                 50 
               
               
                   
                 hsa-miR-1305 
                 55 
               
               
                   
                 hsa-miR-1306 
                 33 
               
               
                   
                 hsa-miR-1307 
                 6293 
               
               
                   
                 hsa-miR-1308 
                 7471 
               
               
                   
                 hsa-miR-130a 
                 30830 
               
               
                   
                 hsa-miR-130a* 
                 43 
               
               
                   
                 hsa-miR-130b 
                 8344 
               
               
                   
                 hsa-miR-130b* 
                 755 
               
               
                   
                 hsa-miR-132 
                 10033 
               
               
                   
                 hsa-miR-132* 
                 1469 
               
               
                   
                 hsa-miR-1321 
                 2 
               
               
                   
                 hsa-miR-1322 
                 12 
               
               
                   
                 hsa-miR-1323 
                 40121 
               
               
                   
                 hsa-miR-1324 
                 0 
               
               
                   
                 hsa-miR-133a 
                 199457 
               
               
                   
                 hsa-miR-133b 
                 6363 
               
               
                   
                 hsa-miR-134 
                 3019 
               
               
                   
                 hsa-miR-135a 
                 108493 
               
               
                   
                 hsa-miR-135a* 
                 121 
               
               
                   
                 hsa-miR-135b 
                 33044 
               
               
                   
                 hsa-miR-135b* 
                 155 
               
               
                   
                 hsa-miR-136 
                 21356 
               
               
                   
                 hsa-miR-136* 
                 5945 
               
               
                   
                 hsa-miR-137 
                 6124 
               
               
                   
                 hsa-miR-138 
                 16603 
               
               
                   
                 hsa-miR-138-1* 
                 503 
               
               
                   
                 hsa-miR-138-2* 
                 50 
               
               
                   
                 hsa-miR-139-3p 
                 1864 
               
               
                   
                 hsa-miR-139-5p 
                 19160 
               
               
                   
                 hsa-miR-140-3p 
                 632569 
               
               
                   
                 hsa-miR-140-5p 
                 99250 
               
               
                   
                 hsa-miR-141 
                 87549 
               
               
                   
                 hsa-miR-141* 
                 1759 
               
               
                   
                 hsa-miR-142-3p 
                 863170 
               
               
                   
                 hsa-miR-142-5p 
                 40824 
               
               
                   
                 hsa-miR-143 
                 27191001 
               
               
                   
                 hsa-miR-143* 
                 131103 
               
               
                   
                 hsa-miR-144 
                 13924 
               
               
                   
                 hsa-miR-144* 
                 141389 
               
               
                   
                 hsa-miR-145 
                 810044 
               
               
                   
                 hsa-miR-145* 
                 32400 
               
               
                   
                 hsa-miR-1468 
                 68 
               
               
                   
                 hsa-miR-1469 
                 0 
               
               
                   
                 hsa-miR-146a 
                 159091 
               
               
                   
                 hsa-miR-146a* 
                 24 
               
               
                   
                 hsa-miR-146b-3p 
                 431 
               
               
                   
                 hsa-miR-146b-5p 
                 945206 
               
               
                   
                 hsa-miR-147 
                 0 
               
               
                   
                 hsa-miR-1470 
                 0 
               
               
                   
                 hsa-miR-1471 
                 0 
               
               
                   
                 hsa-miR-147b 
                 90 
               
               
                   
                 hsa-miR-148a 
                 1306692 
               
               
                   
                 hsa-miR-148a* 
                 6159 
               
               
                   
                 hsa-miR-148b 
                 188242 
               
               
                   
                 hsa-miR-148b* 
                 7002 
               
               
                   
                 hsa-miR-149 
                 2802 
               
               
                   
                 hsa-miR-149* 
                 49 
               
               
                   
                 hsa-miR-150 
                 26608 
               
               
                   
                 hsa-miR-150* 
                 259 
               
               
                   
                 hsa-miR-151-3p 
                 142414 
               
               
                   
                 hsa-miR-151-5p 
                 135256 
               
               
                   
                 hsa-miR-152 
                 179559 
               
               
                   
                 hsa-miR-153 
                 3912 
               
               
                   
                 hsa-miR-1537 
                 22 
               
               
                   
                 hsa-miR-1538 
                 2 
               
               
                   
                 hsa-miR-1539 
                 0 
               
               
                   
                 hsa-miR-154 
                 758 
               
               
                   
                 hsa-miR-154* 
                 270 
               
               
                   
                 hsa-miR-155 
                 162738 
               
               
                   
                 hsa-miR-155* 
                 497 
               
               
                   
                 hsa-miR-15a 
                 45924 
               
               
                   
                 hsa-miR-15a* 
                 47 
               
               
                   
                 hsa-miR-15b 
                 18241 
               
               
                   
                 hsa-miR-15b* 
                 1885 
               
               
                   
                 hsa-miR-16 
                 434371 
               
               
                   
                 hsa-miR-16-1* 
                 327 
               
               
                   
                 hsa-miR-16-2* 
                 1409 
               
               
                   
                 hsa-miR-17 
                 176460 
               
               
                   
                 hsa-miR-17* 
                 12954 
               
               
                   
                 hsa-miR-181a 
                 345345 
               
               
                   
                 hsa-miR-181a* 
                 4960 
               
               
                   
                 hsa-miR-181a-2* 
                 4066 
               
               
                   
                 hsa-miR-181b 
                 49597 
               
               
                   
                 hsa-miR-181c 
                 6636 
               
               
                   
                 hsa-miR-181c* 
                 1044 
               
               
                   
                 hsa-miR-181d 
                 4815 
               
               
                   
                 hsa-miR-182 
                 97847 
               
               
                   
                 hsa-miR-182* 
                 5 
               
               
                   
                 hsa-miR-1825 
                 0 
               
               
                   
                 hsa-miR-1826 
                 3477 
               
               
                   
                 hsa-miR-1827 
                 1 
               
               
                   
                 hsa-miR-183 
                 22483 
               
               
                   
                 hsa-miR-183* 
                 92 
               
               
                   
                 hsa-miR-184 
                 4415 
               
               
                   
                 hsa-miR-185 
                 13309 
               
               
                   
                 hsa-miR-185* 
                 199 
               
               
                   
                 hsa-miR-186 
                 148992 
               
               
                   
                 hsa-miR-186* 
                 433 
               
               
                   
                 hsa-miR-187 
                 790 
               
               
                   
                 hsa-miR-187* 
                 57 
               
               
                   
                 hsa-miR-188-3p 
                 43 
               
               
                   
                 hsa-miR-188-5p 
                 633 
               
               
                   
                 hsa-miR-18a 
                 14206 
               
               
                   
                 hsa-miR-18a* 
                 302 
               
               
                   
                 hsa-miR-18b 
                 147 
               
               
                   
                 hsa-miR-18b* 
                 17 
               
               
                   
                 hsa-miR-190 
                 13151 
               
               
                   
                 hsa-miR-1908 
                 14 
               
               
                   
                 hsa-miR-1909 
                 1 
               
               
                   
                 hsa-miR-1909* 
                 0 
               
               
                   
                 hsa-miR-190b 
                 526 
               
               
                   
                 hsa-miR-191 
                 347191 
               
               
                   
                 hsa-miR-191* 
                 185 
               
               
                   
                 hsa-miR-1910 
                 2 
               
               
                   
                 hsa-miR-1911 
                 149 
               
               
                   
                 hsa-miR-1911* 
                 1 
               
               
                   
                 hsa-miR-1912 
                 21 
               
               
                   
                 hsa-miR-1913 
                 2 
               
               
                   
                 hsa-miR-1914 
                 1 
               
               
                   
                 hsa-miR-1914* 
                 1 
               
               
                   
                 hsa-miR-1915 
                 2 
               
               
                   
                 hsa-miR-1915* 
                 0 
               
               
                   
                 hsa-miR-192 
                 915301 
               
               
                   
                 hsa-miR-192* 
                 1029 
               
               
                   
                 hsa-miR-193a-3p 
                 3073 
               
               
                   
                 hsa-miR-193a-5p 
                 4589 
               
               
                   
                 hsa-miR-193b 
                 29643 
               
               
                   
                 hsa-miR-193b* 
                 1332 
               
               
                   
                 hsa-miR-194 
                 338472 
               
               
                   
                 hsa-miR-194* 
                 572 
               
               
                   
                 hsa-miR-195 
                 76407 
               
               
                   
                 hsa-miR-195* 
                 464 
               
               
                   
                 hsa-miR-196a 
                 8449 
               
               
                   
                 hsa-miR-196a* 
                 33 
               
               
                   
                 hsa-miR-196b 
                 20661 
               
               
                   
                 hsa-miR-196b* 
                 27 
               
               
                   
                 hsa-miR-197 
                 15658 
               
               
                   
                 hsa-miR-1972 
                 0 
               
               
                   
                 hsa-miR-1973 
                 128 
               
               
                   
                 hsa-miR-1975 
                 44554 
               
               
                   
                 hsa-miR-1976 
                 89 
               
               
                   
                 hsa-miR-1979 
                 42616 
               
               
                   
                 hsa-miR-198 
                 2 
               
               
                   
                 hsa-miR-199a-3p 
                 267443 
               
               
                   
                 hsa-miR-199a-5p 
                 58426 
               
               
                   
                 hsa-miR-199b-3p 
                 267443 
               
               
                   
                 hsa-miR-199b-5p 
                 15208 
               
               
                   
                 hsa-miR-19a 
                 28904 
               
               
                   
                 hsa-miR-19a* 
                 27 
               
               
                   
                 hsa-miR-19b 
                 117578 
               
               
                   
                 hsa-miR-19b-1* 
                 545 
               
               
                   
                 hsa-miR-19b-2* 
                 2 
               
               
                   
                 hsa-miR-200a 
                 30201 
               
               
                   
                 hsa-miR-200a* 
                 735 
               
               
                   
                 hsa-miR-200b 
                 52688 
               
               
                   
                 hsa-miR-200b* 
                 4943 
               
               
                   
                 hsa-miR-200c 
                 427036 
               
               
                   
                 hsa-miR-200c* 
                 127 
               
               
                   
                 hsa-miR-202 
                 6243 
               
               
                   
                 hsa-miR-202* 
                 91648 
               
               
                   
                 hsa-miR-203 
                 73346 
               
               
                   
                 hsa-miR-204 
                 8758 
               
               
                   
                 hsa-miR-205 
                 121249 
               
               
                   
                 hsa-miR-205* 
                 21 
               
               
                   
                 hsa-miR-2052 
                 0 
               
               
                   
                 hsa-miR-2053 
                 0 
               
               
                   
                 hsa-miR-2054 
                 0 
               
               
                   
                 hsa-miR-206 
                 239800 
               
               
                   
                 hsa-miR-208a 
                 457 
               
               
                   
                 hsa-miR-208b 
                 3831 
               
               
                   
                 hsa-miR-20a 
                 261873 
               
               
                   
                 hsa-miR-20a* 
                 4565 
               
               
                   
                 hsa-miR-20b 
                 14523 
               
               
                   
                 hsa-miR-20b* 
                 181 
               
               
                   
                 hsa-miR-21 
                 6223972 
               
               
                   
                 hsa-miR-21* 
                 4482 
               
               
                   
                 hsa-miR-210 
                 14772 
               
               
                   
                 hsa-miR-211 
                 31 
               
               
                   
                 hsa-miR-2110 
                 1305 
               
               
                   
                 hsa-miR-2113 
                 0 
               
               
                   
                 hsa-miR-2114 
                 93 
               
               
                   
                 hsa-miR-2114* 
                 11 
               
               
                   
                 hsa-miR-2115 
                 46 
               
               
                   
                 hsa-miR-2115* 
                 85 
               
               
                   
                 hsa-miR-2116 
                 32 
               
               
                   
                 hsa-miR-2116* 
                 33 
               
               
                   
                 hsa-miR-2117 
                 0 
               
               
                   
                 hsa-miR-212 
                 317 
               
               
                   
                 hsa-miR-214 
                 13273 
               
               
                   
                 hsa-miR-214* 
                 2118 
               
               
                   
                 hsa-miR-215 
                 848606 
               
               
                   
                 hsa-miR-216a 
                 260 
               
               
                   
                 hsa-miR-216b 
                 705 
               
               
                   
                 hsa-miR-217 
                 754 
               
               
                   
                 hsa-miR-218 
                 22992 
               
               
                   
                 hsa-miR-218-1* 
                 624 
               
               
                   
                 hsa-miR-218-2* 
                 26 
               
               
                   
                 hsa-miR-219-1-3p 
                 108 
               
               
                   
                 hsa-miR-219-2-3p 
                 26649 
               
               
                   
                 hsa-miR-219-5p 
                 500 
               
               
                   
                 hsa-miR-22 
                 159941 
               
               
                   
                 hsa-miR-22* 
                 12506 
               
               
                   
                 hsa-miR-220a 
                 0 
               
               
                   
                 hsa-miR-220b 
                 0 
               
               
                   
                 hsa-miR-220c 
                 0 
               
               
                   
                 hsa-miR-221 
                 44792 
               
               
                   
                 hsa-miR-221* 
                 17403 
               
               
                   
                 hsa-miR-222 
                 94321 
               
               
                   
                 hsa-miR-222* 
                 430 
               
               
                   
                 hsa-miR-223 
                 37671 
               
               
                   
                 hsa-miR-223* 
                 1142 
               
               
                   
                 hsa-miR-224 
                 8474 
               
               
                   
                 hsa-miR-224* 
                 438 
               
               
                   
                 hsa-miR-2276 
                 105 
               
               
                   
                 hsa-miR-2277 
                 30 
               
               
                   
                 hsa-miR-2278 
                 12 
               
               
                   
                 hsa-miR-2355 
                 80 
               
               
                   
                 hsa-miR-23a 
                 243206 
               
               
                   
                 hsa-miR-23a* 
                 23 
               
               
                   
                 hsa-miR-23b 
                 210543 
               
               
                   
                 hsa-miR-23b* 
                 231 
               
               
                   
                 hsa-miR-24 
                 1502194 
               
               
                   
                 hsa-miR-24-1* 
                 3733 
               
               
                   
                 hsa-miR-24-2* 
                 6950 
               
               
                   
                 hsa-miR-25 
                 33806 
               
               
                   
                 hsa-miR-25* 
                 649 
               
               
                   
                 hsa-miR-26a 
                 1986940 
               
               
                   
                 hsa-miR-26a-1* 
                 62 
               
               
                   
                 hsa-miR-26a-2* 
                 834 
               
               
                   
                 hsa-miR-26b 
                 482254 
               
               
                   
                 hsa-miR-26b* 
                 679 
               
               
                   
                 hsa-miR-27a 
                 267030 
               
               
                   
                 hsa-miR-27a* 
                 745 
               
               
                   
                 hsa-miR-27b 
                 673420 
               
               
                   
                 hsa-miR-27b* 
                 8575 
               
               
                   
                 hsa-miR-28-3p 
                 52126 
               
               
                   
                 hsa-miR-28-5p 
                 60747 
               
               
                   
                 hsa-miR-2861 
                 0 
               
               
                   
                 hsa-miR-2909 
                 0 
               
               
                   
                 hsa-miR-296-3p 
                 116 
               
               
                   
                 hsa-miR-296-5p 
                 465 
               
               
                   
                 hsa-miR-297 
                 0 
               
               
                   
                 hsa-miR-298 
                 0 
               
               
                   
                 hsa-miR-299-3p 
                 427 
               
               
                   
                 hsa-miR-299-5p 
                 860 
               
               
                   
                 hsa-miR-29a 
                 758430 
               
               
                   
                 hsa-miR-29a* 
                 4199 
               
               
                   
                 hsa-miR-29b 
                 224003 
               
               
                   
                 hsa-miR-29b-1* 
                 332 
               
               
                   
                 hsa-miR-29b-2* 
                 1741 
               
               
                   
                 hsa-miR-29c 
                 50309 
               
               
                   
                 hsa-miR-29c* 
                 5043 
               
               
                   
                 hsa-miR-300 
                 0 
               
               
                   
                 hsa-miR-301a 
                 1455 
               
               
                   
                 hsa-miR-301b 
                 289 
               
               
                   
                 hsa-miR-302a 
                 34 
               
               
                   
                 hsa-miR-302a* 
                 132 
               
               
                   
                 hsa-miR-302b 
                 81 
               
               
                   
                 hsa-miR-302b* 
                 2 
               
               
                   
                 hsa-miR-302c 
                 11 
               
               
                   
                 hsa-miR-302c* 
                 0 
               
               
                   
                 hsa-miR-302d 
                 23 
               
               
                   
                 hsa-miR-302d* 
                 0 
               
               
                   
                 hsa-miR-302e 
                 0 
               
               
                   
                 hsa-miR-302f 
                 0 
               
               
                   
                 hsa-miR-3065-3p 
                 1456 
               
               
                   
                 hsa-miR-3065-5p 
                 1144 
               
               
                   
                 hsa-miR-3074 
                 18 
               
               
                   
                 hsa-miR-30a 
                 2082964 
               
               
                   
                 hsa-miR-30a* 
                 90594 
               
               
                   
                 hsa-miR-30b 
                 253420 
               
               
                   
                 hsa-miR-30b* 
                 583 
               
               
                   
                 hsa-miR-30c 
                 363593 
               
               
                   
                 hsa-miR-30c-1* 
                 432 
               
               
                   
                 hsa-miR-30c-2* 
                 5633 
               
               
                   
                 hsa-miR-30d 
                 1167397 
               
               
                   
                 hsa-miR-30d* 
                 1597 
               
               
                   
                 hsa-miR-30e 
                 888607 
               
               
                   
                 hsa-miR-30e* 
                 96423 
               
               
                   
                 hsa-miR-31 
                 11912 
               
               
                   
                 hsa-miR-31* 
                 370 
               
               
                   
                 hsa-miR-3115 
                 19 
               
               
                   
                 hsa-miR-3116 
                 5 
               
               
                   
                 hsa-miR-3117 
                 116 
               
               
                   
                 hsa-miR-3118 
                 1 
               
               
                   
                 hsa-miR-3119 
                 0 
               
               
                   
                 hsa-miR-3120 
                 8 
               
               
                   
                 hsa-miR-3121 
                 21 
               
               
                   
                 hsa-miR-3122 
                 4 
               
               
                   
                 hsa-miR-3123 
                 0 
               
               
                   
                 hsa-miR-3124 
                 46 
               
               
                   
                 hsa-miR-3125 
                 32 
               
               
                   
                 hsa-miR-3126-3p 
                 5 
               
               
                   
                 hsa-miR-3126-5p 
                 7 
               
               
                   
                 hsa-miR-3127 
                 53 
               
               
                   
                 hsa-miR-3128 
                 30 
               
               
                   
                 hsa-miR-3129 
                 81 
               
               
                   
                 hsa-miR-3130-3p 
                 1 
               
               
                   
                 hsa-miR-3130-5p 
                 31 
               
               
                   
                 hsa-miR-3131 
                 9 
               
               
                   
                 hsa-miR-3132 
                 7 
               
               
                   
                 hsa-miR-3133 
                 18 
               
               
                   
                 hsa-miR-3134 
                 12 
               
               
                   
                 hsa-miR-3135 
                 4 
               
               
                   
                 hsa-miR-3136 
                 15 
               
               
                   
                 hsa-miR-3137 
                 0 
               
               
                   
                 hsa-miR-3138 
                 22 
               
               
                   
                 hsa-miR-3139 
                 9 
               
               
                   
                 hsa-miR-3140 
                 19 
               
               
                   
                 hsa-miR-3141 
                 9 
               
               
                   
                 hsa-miR-3142 
                 0 
               
               
                   
                 hsa-miR-3143 
                 9 
               
               
                   
                 hsa-miR-3144-3p 
                 6 
               
               
                   
                 hsa-miR-3144-5p 
                 11 
               
               
                   
                 hsa-miR-3145 
                 13 
               
               
                   
                 hsa-miR-3146 
                 34 
               
               
                   
                 hsa-miR-3147 
                 0 
               
               
                   
                 hsa-miR-3148 
                 1 
               
               
                   
                 hsa-miR-3149 
                 27 
               
               
                   
                 hsa-miR-3150 
                 1 
               
               
                   
                 hsa-miR-3151 
                 2 
               
               
                   
                 hsa-miR-3152 
                 1 
               
               
                   
                 hsa-miR-3153 
                 0 
               
               
                   
                 hsa-miR-3154 
                 129 
               
               
                   
                 hsa-miR-3155 
                 2 
               
               
                   
                 hsa-miR-3156 
                 1 
               
               
                   
                 hsa-miR-3157 
                 22 
               
               
                   
                 hsa-miR-3158 
                 221 
               
               
                   
                 hsa-miR-3159 
                 6 
               
               
                   
                 hsa-miR-3160 
                 4 
               
               
                   
                 hsa-miR-3161 
                 11 
               
               
                   
                 hsa-miR-3162 
                 1 
               
               
                   
                 hsa-miR-3163 
                 21 
               
               
                   
                 hsa-miR-3164 
                 60 
               
               
                   
                 hsa-miR-3165 
                 0 
               
               
                   
                 hsa-miR-3166 
                 2 
               
               
                   
                 hsa-miR-3167 
                 6 
               
               
                   
                 hsa-miR-3168 
                 4 
               
               
                   
                 hsa-miR-3169 
                 0 
               
               
                   
                 hsa-miR-3170 
                 5 
               
               
                   
                 hsa-miR-3171 
                 2 
               
               
                   
                 hsa-miR-3172 
                 729 
               
               
                   
                 hsa-miR-3173 
                 9 
               
               
                   
                 hsa-miR-3174 
                 21 
               
               
                   
                 hsa-miR-3175 
                 10 
               
               
                   
                 hsa-miR-3176 
                 59 
               
               
                   
                 hsa-miR-3177 
                 63 
               
               
                   
                 hsa-miR-3178 
                 0 
               
               
                   
                 hsa-miR-3179 
                 23 
               
               
                   
                 hsa-miR-3180-3p 
                 14 
               
               
                   
                 hsa-miR-3180-5p 
                 10 
               
               
                   
                 hsa-miR-3181 
                 5 
               
               
                   
                 hsa-miR-3182 
                 11 
               
               
                   
                 hsa-miR-3183 
                 1 
               
               
                   
                 hsa-miR-3184 
                 2 
               
               
                   
                 hsa-miR-3185 
                 0 
               
               
                   
                 hsa-miR-3186-3p 
                 0 
               
               
                   
                 hsa-miR-3186-5p 
                 1 
               
               
                   
                 hsa-miR-3187 
                 25 
               
               
                   
                 hsa-miR-3188 
                 118 
               
               
                   
                 hsa-miR-3189 
                 2 
               
               
                   
                 hsa-miR-3190-3p 
                 22 
               
               
                   
                 hsa-miR-3190-5p 
                 22 
               
               
                   
                 hsa-miR-3191 
                 5 
               
               
                   
                 hsa-miR-3192 
                 11 
               
               
                   
                 hsa-miR-3193 
                 7 
               
               
                   
                 hsa-miR-3194 
                 52 
               
               
                   
                 hsa-miR-3195 
                 6 
               
               
                   
                 hsa-miR-3196 
                 10 
               
               
                   
                 hsa-miR-3197 
                 0 
               
               
                   
                 hsa-miR-3198 
                 1 
               
               
                   
                 hsa-miR-3199 
                 62 
               
               
                   
                 hsa-miR-32 
                 25140 
               
               
                   
                 hsa-miR-32* 
                 301 
               
               
                   
                 hsa-miR-3200 
                 515 
               
               
                   
                 hsa-miR-3201 
                 0 
               
               
                   
                 hsa-miR-3202 
                 28 
               
               
                   
                 hsa-miR-320a 
                 111802 
               
               
                   
                 hsa-miR-320b 
                 8719 
               
               
                   
                 hsa-miR-320c 
                 5424 
               
               
                   
                 hsa-miR-320d 
                 5980 
               
               
                   
                 hsa-miR-320e 
                 241 
               
               
                   
                 hsa-miR-323-3p 
                 662 
               
               
                   
                 hsa-miR-323-5p 
                 8 
               
               
                   
                 hsa-miR-323b-3p 
                 216 
               
               
                   
                 hsa-miR-323b-5p 
                 2 
               
               
                   
                 hsa-miR-324-3p 
                 1220 
               
               
                   
                 hsa-miR-324-5p 
                 2258 
               
               
                   
                 hsa-miR-325 
                 0 
               
               
                   
                 hsa-miR-326 
                 199 
               
               
                   
                 hsa-miR-328 
                 2414 
               
               
                   
                 hsa-miR-329 
                 1531 
               
               
                   
                 hsa-miR-330-3p 
                 4705 
               
               
                   
                 hsa-miR-330-5p 
                 751 
               
               
                   
                 hsa-miR-331-3p 
                 1768 
               
               
                   
                 hsa-miR-331-5p 
                 637 
               
               
                   
                 hsa-miR-335 
                 38506 
               
               
                   
                 hsa-miR-335* 
                 7818 
               
               
                   
                 hsa-miR-337-3p 
                 3906 
               
               
                   
                 hsa-miR-337-5p 
                 4909 
               
               
                   
                 hsa-miR-338-3p 
                 8532 
               
               
                   
                 hsa-miR-338-5p 
                 5359 
               
               
                   
                 hsa-miR-339-3p 
                 10563 
               
               
                   
                 hsa-miR-339-5p 
                 2593 
               
               
                   
                 hsa-miR-33a 
                 13217 
               
               
                   
                 hsa-miR-33a* 
                 371 
               
               
                   
                 hsa-miR-33b 
                 1119 
               
               
                   
                 hsa-miR-33b* 
                 78 
               
               
                   
                 hsa-miR-340 
                 28380 
               
               
                   
                 hsa-miR-340* 
                 2305 
               
               
                   
                 hsa-miR-342-3p 
                 24621 
               
               
                   
                 hsa-miR-342-5p 
                 2668 
               
               
                   
                 hsa-miR-345 
                 3394 
               
               
                   
                 hsa-miR-346 
                 108 
               
               
                   
                 hsa-miR-34a 
                 13143 
               
               
                   
                 hsa-miR-34a* 
                 92 
               
               
                   
                 hsa-miR-34b 
                 1191 
               
               
                   
                 hsa-miR-34b* 
                 1105 
               
               
                   
                 hsa-miR-34c-3p 
                 1826 
               
               
                   
                 hsa-miR-34c-5p 
                 38125 
               
               
                   
                 hsa-miR-361-3p 
                 3940 
               
               
                   
                 hsa-miR-361-5p 
                 21423 
               
               
                   
                 hsa-miR-362-3p 
                 739 
               
               
                   
                 hsa-miR-362-5p 
                 2360 
               
               
                   
                 hsa-miR-363 
                 16685 
               
               
                   
                 hsa-miR-363* 
                 24 
               
               
                   
                 hsa-miR-365 
                 20092 
               
               
                   
                 hsa-miR-365* 
                 205 
               
               
                   
                 hsa-miR-367 
                 15 
               
               
                   
                 hsa-miR-367* 
                 0 
               
               
                   
                 hsa-miR-369-3p 
                 6883 
               
               
                   
                 hsa-miR-369-5p 
                 1237 
               
               
                   
                 hsa-miR-370 
                 726 
               
               
                   
                 hsa-miR-371-3p 
                 22 
               
               
                   
                 hsa-miR-371-5p 
                 132 
               
               
                   
                 hsa-miR-372 
                 421 
               
               
                   
                 hsa-miR-373 
                 280 
               
               
                   
                 hsa-miR-373* 
                 16 
               
               
                   
                 hsa-miR-374a 
                 51385 
               
               
                   
                 hsa-miR-374a* 
                 114379 
               
               
                   
                 hsa-miR-374b 
                 39066 
               
               
                   
                 hsa-miR-374b* 
                 1323 
               
               
                   
                 hsa-miR-375 
                 22890 
               
               
                   
                 hsa-miR-376a 
                 1004 
               
               
                   
                 hsa-miR-376a* 
                 1912 
               
               
                   
                 hsa-miR-376b 
                 1253 
               
               
                   
                 hsa-miR-376c 
                 27443 
               
               
                   
                 hsa-miR-377 
                 4408 
               
               
                   
                 hsa-miR-377* 
                 75 
               
               
                   
                 hsa-miR-378 
                 4360229 
               
               
                   
                 hsa-miR-378* 
                 2959 
               
               
                   
                 hsa-miR-378b 
                 33 
               
               
                   
                 hsa-miR-378c 
                 43898 
               
               
                   
                 hsa-miR-379 
                 46853 
               
               
                   
                 hsa-miR-379* 
                 210 
               
               
                   
                 hsa-miR-380 
                 122 
               
               
                   
                 hsa-miR-380* 
                 491 
               
               
                   
                 hsa-miR-381 
                 18003 
               
               
                   
                 hsa-miR-382 
                 2040 
               
               
                   
                 hsa-miR-383 
                 829 
               
               
                   
                 hsa-miR-384 
                 0 
               
               
                   
                 hsa-miR-409-3p 
                 1561 
               
               
                   
                 hsa-miR-409-5p 
                 477 
               
               
                   
                 hsa-miR-410 
                 1428 
               
               
                   
                 hsa-miR-411 
                 12443 
               
               
                   
                 hsa-miR-411* 
                 534 
               
               
                   
                 hsa-miR-412 
                 1 
               
               
                   
                 hsa-miR-421 
                 2693 
               
               
                   
                 hsa-miR-422a 
                 11 
               
               
                   
                 hsa-miR-423-3p 
                 37223 
               
               
                   
                 hsa-miR-423-5p 
                 83406 
               
               
                   
                 hsa-miR-424 
                 209609 
               
               
                   
                 hsa-miR-424* 
                 2020 
               
               
                   
                 hsa-miR-425 
                 77674 
               
               
                   
                 hsa-miR-425* 
                 3099 
               
               
                   
                 hsa-miR-4251 
                 0 
               
               
                   
                 hsa-miR-4252 
                 0 
               
               
                   
                 hsa-miR-4253 
                 0 
               
               
                   
                 hsa-miR-4254 
                 4 
               
               
                   
                 hsa-miR-4255 
                 0 
               
               
                   
                 hsa-miR-4256 
                 0 
               
               
                   
                 hsa-miR-4257 
                 0 
               
               
                   
                 hsa-miR-4258 
                 0 
               
               
                   
                 hsa-miR-4259 
                 0 
               
               
                   
                 hsa-miR-4260 
                 0 
               
               
                   
                 hsa-miR-4261 
                 0 
               
               
                   
                 hsa-miR-4262 
                 0 
               
               
                   
                 hsa-miR-4263 
                 0 
               
               
                   
                 hsa-miR-4264 
                 0 
               
               
                   
                 hsa-miR-4265 
                 0 
               
               
                   
                 hsa-miR-4266 
                 0 
               
               
                   
                 hsa-miR-4267 
                 0 
               
               
                   
                 hsa-miR-4268 
                 0 
               
               
                   
                 hsa-miR-4269 
                 0 
               
               
                   
                 hsa-miR-4270 
                 0 
               
               
                   
                 hsa-miR-4271 
                 0 
               
               
                   
                 hsa-miR-4272 
                 0 
               
               
                   
                 hsa-miR-4273 
                 0 
               
               
                   
                 hsa-miR-4274 
                 0 
               
               
                   
                 hsa-miR-4275 
                 0 
               
               
                   
                 hsa-miR-4276 
                 0 
               
               
                   
                 hsa-miR-4277 
                 0 
               
               
                   
                 hsa-miR-4278 
                 0 
               
               
                   
                 hsa-miR-4279 
                 0 
               
               
                   
                 hsa-miR-4280 
                 0 
               
               
                   
                 hsa-miR-4281 
                 0 
               
               
                   
                 hsa-miR-4282 
                 0 
               
               
                   
                 hsa-miR-4283 
                 0 
               
               
                   
                 hsa-miR-4284 
                 1392 
               
               
                   
                 hsa-miR-4285 
                 0 
               
               
                   
                 hsa-miR-4286 
                 1480 
               
               
                   
                 hsa-miR-4287 
                 0 
               
               
                   
                 hsa-miR-4288 
                 0 
               
               
                   
                 hsa-miR-4289 
                 0 
               
               
                   
                 hsa-miR-429 
                 21310 
               
               
                   
                 hsa-miR-4290 
                 0 
               
               
                   
                 hsa-miR-4291 
                 0 
               
               
                   
                 hsa-miR-4292 
                 0 
               
               
                   
                 hsa-miR-4293 
                 0 
               
               
                   
                 hsa-miR-4294 
                 0 
               
               
                   
                 hsa-miR-4295 
                 0 
               
               
                   
                 hsa-miR-4296 
                 1 
               
               
                   
                 hsa-miR-4297 
                 0 
               
               
                   
                 hsa-miR-4298 
                 0 
               
               
                   
                 hsa-miR-4299 
                 0 
               
               
                   
                 hsa-miR-4300 
                 0 
               
               
                   
                 hsa-miR-4301 
                 0 
               
               
                   
                 hsa-miR-4302 
                 0 
               
               
                   
                 hsa-miR-4303 
                 0 
               
               
                   
                 hsa-miR-4304 
                 0 
               
               
                   
                 hsa-miR-4305 
                 0 
               
               
                   
                 hsa-miR-4306 
                 6 
               
               
                   
                 hsa-miR-4307 
                 0 
               
               
                   
                 hsa-miR-4308 
                 0 
               
               
                   
                 hsa-miR-4309 
                 0 
               
               
                   
                 hsa-miR-431 
                 128 
               
               
                   
                 hsa-miR-431* 
                 145 
               
               
                   
                 hsa-miR-4310 
                 0 
               
               
                   
                 hsa-miR-4311 
                 0 
               
               
                   
                 hsa-miR-4312 
                 0 
               
               
                   
                 hsa-miR-4313 
                 0 
               
               
                   
                 hsa-miR-4314 
                 0 
               
               
                   
                 hsa-miR-4315 
                 0 
               
               
                   
                 hsa-miR-4316 
                 0 
               
               
                   
                 hsa-miR-4317 
                 0 
               
               
                   
                 hsa-miR-4318 
                 0 
               
               
                   
                 hsa-miR-4319 
                 0 
               
               
                   
                 hsa-miR-432 
                 1080 
               
               
                   
                 hsa-miR-432* 
                 10 
               
               
                   
                 hsa-miR-4320 
                 0 
               
               
                   
                 hsa-miR-4321 
                 0 
               
               
                   
                 hsa-miR-4322 
                 0 
               
               
                   
                 hsa-miR-4323 
                 1 
               
               
                   
                 hsa-miR-4324 
                 0 
               
               
                   
                 hsa-miR-4325 
                 0 
               
               
                   
                 hsa-miR-4326 
                 73 
               
               
                   
                 hsa-miR-4327 
                 0 
               
               
                   
                 hsa-miR-4328 
                 27 
               
               
                   
                 hsa-miR-4329 
                 0 
               
               
                   
                 hsa-miR-433 
                 529 
               
               
                   
                 hsa-miR-4330 
                 0 
               
               
                   
                 hsa-miR-448 
                 8 
               
               
                   
                 hsa-miR-449a 
                 8663 
               
               
                   
                 hsa-miR-449b 
                 1369 
               
               
                   
                 hsa-miR-449b* 
                 29 
               
               
                   
                 hsa-miR-449c 
                 2070 
               
               
                   
                 hsa-miR-449c* 
                 0 
               
               
                   
                 hsa-miR-450a 
                 10118 
               
               
                   
                 hsa-miR-450b-3p 
                 32 
               
               
                   
                 hsa-miR-450b-5p 
                 4838 
               
               
                   
                 hsa-miR-451 
                 737681 
               
               
                   
                 hsa-miR-452 
                 104661 
               
               
                   
                 hsa-miR-452* 
                 2187 
               
               
                   
                 hsa-miR-454 
                 16148 
               
               
                   
                 hsa-miR-454* 
                 111 
               
               
                   
                 hsa-miR-455-3p 
                 14394 
               
               
                   
                 hsa-miR-455-5p 
                 3633 
               
               
                   
                 hsa-miR-466 
                 3 
               
               
                   
                 hsa-miR-483-3p 
                 395 
               
               
                   
                 hsa-miR-483-5p 
                 3635 
               
               
                   
                 hsa-miR-484 
                 2717 
               
               
                   
                 hsa-miR-485-3p 
                 545 
               
               
                   
                 hsa-miR-485-5p 
                 1942 
               
               
                   
                 hsa-miR-486-3p 
                 296 
               
               
                   
                 hsa-miR-486-5p 
                 12961 
               
               
                   
                 hsa-miR-487a 
                 707 
               
               
                   
                 hsa-miR-487b 
                 3131 
               
               
                   
                 hsa-miR-488 
                 328 
               
               
                   
                 hsa-miR-488* 
                 26 
               
               
                   
                 hsa-miR-489 
                 644 
               
               
                   
                 hsa-miR-490-3p 
                 1085 
               
               
                   
                 hsa-miR-490-5p 
                 906 
               
               
                   
                 hsa-miR-491-3p 
                 97 
               
               
                   
                 hsa-miR-491-5p 
                 761 
               
               
                   
                 hsa-miR-492 
                 6 
               
               
                   
                 hsa-miR-493 
                 1152 
               
               
                   
                 hsa-miR-493* 
                 2341 
               
               
                   
                 hsa-miR-494 
                 2613 
               
               
                   
                 hsa-miR-495 
                 2968 
               
               
                   
                 hsa-miR-496 
                 93 
               
               
                   
                 hsa-miR-497 
                 9453 
               
               
                   
                 hsa-miR-497* 
                 249 
               
               
                   
                 hsa-miR-498 
                 1074 
               
               
                   
                 hsa-miR-499-3p 
                 7353 
               
               
                   
                 hsa-miR-499-5p 
                 16967 
               
               
                   
                 hsa-miR-500 
                 1116 
               
               
                   
                 hsa-miR-500* 
                 3156 
               
               
                   
                 hsa-miR-500b 
                 907 
               
               
                   
                 hsa-miR-501-3p 
                 736 
               
               
                   
                 hsa-miR-501-5p 
                 546 
               
               
                   
                 hsa-miR-502-3p 
                 1821 
               
               
                   
                 hsa-miR-502-5p 
                 188 
               
               
                   
                 hsa-miR-503 
                 5056 
               
               
                   
                 hsa-miR-504 
                 637 
               
               
                   
                 hsa-miR-505 
                 3599 
               
               
                   
                 hsa-miR-505* 
                 598 
               
               
                   
                 hsa-miR-506 
                 16376 
               
               
                   
                 hsa-miR-507 
                 840 
               
               
                   
                 hsa-miR-508-3p 
                 76162 
               
               
                   
                 hsa-miR-508-5p 
                 1212 
               
               
                   
                 hsa-miR-509-3-5p 
                 3903 
               
               
                   
                 hsa-miR-509-3p 
                 7241 
               
               
                   
                 hsa-miR-509-5p 
                 9245 
               
               
                   
                 hsa-miR-510 
                 1916 
               
               
                   
                 hsa-miR-511 
                 277 
               
               
                   
                 hsa-miR-512-3p 
                 5968 
               
               
                   
                 hsa-miR-512-5p 
                 1757 
               
               
                   
                 hsa-miR-513a-3p 
                 544 
               
               
                   
                 hsa-miR-513a-5p 
                 2002 
               
               
                   
                 hsa-miR-513b 
                 1058 
               
               
                   
                 hsa-miR-513c 
                 3568 
               
               
                   
                 hsa-miR-514 
                 156995 
               
               
                   
                 hsa-miR-514b-3p 
                 711 
               
               
                   
                 hsa-miR-514b-5p 
                 2112 
               
               
                   
                 hsa-miR-515-3p 
                 2866 
               
               
                   
                 hsa-miR-515-5p 
                 18861 
               
               
                   
                 hsa-miR-516a-3p 
                 263 
               
               
                   
                 hsa-miR-516a-5p 
                 56271 
               
               
                   
                 hsa-miR-516b 
                 32784 
               
               
                   
                 hsa-miR-516b* 
                 263 
               
               
                   
                 hsa-miR-517* 
                 1742 
               
               
                   
                 hsa-miR-517a 
                 34727 
               
               
                   
                 hsa-miR-517b 
                 34727 
               
               
                   
                 hsa-miR-517c 
                 8109 
               
               
                   
                 hsa-miR-518a-3p 
                 8007 
               
               
                   
                 hsa-miR-518a-5p 
                 1202 
               
               
                   
                 hsa-miR-518b 
                 16097 
               
               
                   
                 hsa-miR-518c 
                 33419 
               
               
                   
                 hsa-miR-518c* 
                 610 
               
               
                   
                 hsa-miR-518d-3p 
                 262 
               
               
                   
                 hsa-miR-518d-5p 
                 1426 
               
               
                   
                 hsa-miR-518e 
                 5542 
               
               
                   
                 hsa-miR-518e* 
                 17339 
               
               
                   
                 hsa-miR-518f 
                 10142 
               
               
                   
                 hsa-miR-518f* 
                 1041 
               
               
                   
                 hsa-miR-519a 
                 16658 
               
               
                   
                 hsa-miR-519a* 
                 17339 
               
               
                   
                 hsa-miR-519b-3p 
                 2282 
               
               
                   
                 hsa-miR-519b-5p 
                 17339 
               
               
                   
                 hsa-miR-519c-3p 
                 5238 
               
               
                   
                 hsa-miR-519c-5p 
                 17339 
               
               
                   
                 hsa-miR-519d 
                 9568 
               
               
                   
                 hsa-miR-519e 
                 190 
               
               
                   
                 hsa-miR-519e* 
                 494 
               
               
                   
                 hsa-miR-520a-3p 
                 2395 
               
               
                   
                 hsa-miR-520a-5p 
                 2644 
               
               
                   
                 hsa-miR-520b 
                 1691 
               
               
                   
                 hsa-miR-520c-3p 
                 1691 
               
               
                   
                 hsa-miR-520c-5p 
                 1426 
               
               
                   
                 hsa-miR-520d-3p 
                 1408 
               
               
                   
                 hsa-miR-520d-5p 
                 841 
               
               
                   
                 hsa-miR-520e 
                 205 
               
               
                   
                 hsa-miR-520f 
                 3634 
               
               
                   
                 hsa-miR-520g 
                 7961 
               
               
                   
                 hsa-miR-520h 
                 10836 
               
               
                   
                 hsa-miR-521 
                 2359 
               
               
                   
                 hsa-miR-522 
                 4224 
               
               
                   
                 hsa-miR-522* 
                 17339 
               
               
                   
                 hsa-miR-523 
                 16402 
               
               
                   
                 hsa-miR-523* 
                 17339 
               
               
                   
                 hsa-miR-524-3p 
                 1566 
               
               
                   
                 hsa-miR-524-5p 
                 1943 
               
               
                   
                 hsa-miR-525-3p 
                 7310 
               
               
                   
                 hsa-miR-525-5p 
                 4442 
               
               
                   
                 hsa-miR-526a 
                 1426 
               
               
                   
                 hsa-miR-526b 
                 6191 
               
               
                   
                 hsa-miR-526b* 
                 1651 
               
               
                   
                 hsa-miR-527 
                 1202 
               
               
                   
                 hsa-miR-532-3p 
                 3688 
               
               
                   
                 hsa-miR-532-5p 
                 14360 
               
               
                   
                 hsa-miR-539 
                 1024 
               
               
                   
                 hsa-miR-541 
                 13 
               
               
                   
                 hsa-miR-541* 
                 9 
               
               
                   
                 hsa-miR-542-3p 
                 30135 
               
               
                   
                 hsa-miR-542-5p 
                 2681 
               
               
                   
                 hsa-miR-543 
                 511 
               
               
                   
                 hsa-miR-544 
                 30 
               
               
                   
                 hsa-miR-544b 
                 2 
               
               
                   
                 hsa-miR-545 
                 84 
               
               
                   
                 hsa-miR-545* 
                 146 
               
               
                   
                 hsa-miR-548a-3p 
                 133 
               
               
                   
                 hsa-miR-548a-5p 
                 15 
               
               
                   
                 hsa-miR-548b-3p 
                 102 
               
               
                   
                 hsa-miR-548b-5p 
                 40 
               
               
                   
                 hsa-miR-548c-3p 
                 18 
               
               
                   
                 hsa-miR-548c-5p 
                 290 
               
               
                   
                 hsa-miR-548d-3p 
                 46 
               
               
                   
                 hsa-miR-548d-5p 
                 467 
               
               
                   
                 hsa-miR-548e 
                 754 
               
               
                   
                 hsa-miR-548f 
                 220 
               
               
                   
                 hsa-miR-548g 
                 1 
               
               
                   
                 hsa-miR-548h 
                 18 
               
               
                   
                 hsa-miR-548i 
                 106 
               
               
                   
                 hsa-miR-548j 
                 242 
               
               
                   
                 hsa-miR-548k 
                 210 
               
               
                   
                 hsa-miR-548l 
                 56 
               
               
                   
                 hsa-miR-548m 
                 0 
               
               
                   
                 hsa-miR-548n 
                 55 
               
               
                   
                 hsa-miR-548o 
                 231 
               
               
                   
                 hsa-miR-548p 
                 5 
               
               
                   
                 hsa-miR-548q 
                 79 
               
               
                   
                 hsa-miR-548s 
                 11 
               
               
                   
                 hsa-miR-548t 
                 19 
               
               
                   
                 hsa-miR-548u 
                 4 
               
               
                   
                 hsa-miR-548v 
                 46 
               
               
                   
                 hsa-miR-548w 
                 3 
               
               
                   
                 hsa-miR-548x 
                 0 
               
               
                   
                 hsa-miR-549 
                 26 
               
               
                   
                 hsa-miR-550 
                 183 
               
               
                   
                 hsa-miR-550* 
                 125 
               
               
                   
                 hsa-miR-551a 
                 28 
               
               
                   
                 hsa-miR-551b 
                 129 
               
               
                   
                 hsa-miR-551b* 
                 31 
               
               
                   
                 hsa-miR-552 
                 61 
               
               
                   
                 hsa-miR-553 
                 0 
               
               
                   
                 hsa-miR-554 
                 0 
               
               
                   
                 hsa-miR-555 
                 0 
               
               
                   
                 hsa-miR-556-3p 
                 24 
               
               
                   
                 hsa-miR-556-5p 
                 141 
               
               
                   
                 hsa-miR-557 
                 0 
               
               
                   
                 hsa-miR-558 
                 0 
               
               
                   
                 hsa-miR-559 
                 6 
               
               
                   
                 hsa-miR-561 
                 24 
               
               
                   
                 hsa-miR-562 
                 0 
               
               
                   
                 hsa-miR-563 
                 0 
               
               
                   
                 hsa-miR-564 
                 1 
               
               
                   
                 hsa-miR-566 
                 0 
               
               
                   
                 hsa-miR-567 
                 0 
               
               
                   
                 hsa-miR-568 
                 0 
               
               
                   
                 hsa-miR-569 
                 0 
               
               
                   
                 hsa-miR-570 
                 146 
               
               
                   
                 hsa-miR-571 
                 0 
               
               
                   
                 hsa-miR-572 
                 1 
               
               
                   
                 hsa-miR-573 
                 199 
               
               
                   
                 hsa-miR-574-3p 
                 10204 
               
               
                   
                 hsa-miR-574-5p 
                 1628 
               
               
                   
                 hsa-miR-575 
                 0 
               
               
                   
                 hsa-miR-576-3p 
                 683 
               
               
                   
                 hsa-miR-576-5p 
                 1574 
               
               
                   
                 hsa-miR-577 
                 3344 
               
               
                   
                 hsa-miR-578 
                 0 
               
               
                   
                 hsa-miR-579 
                 63 
               
               
                   
                 hsa-miR-580 
                 150 
               
               
                   
                 hsa-miR-581 
                 17 
               
               
                   
                 hsa-miR-582-3p 
                 3511 
               
               
                   
                 hsa-miR-582-5p 
                 2439 
               
               
                   
                 hsa-miR-583 
                 0 
               
               
                   
                 hsa-miR-584 
                 1494 
               
               
                   
                 hsa-miR-585 
                 436 
               
               
                   
                 hsa-miR-586 
                 0 
               
               
                   
                 hsa-miR-587 
                 0 
               
               
                   
                 hsa-miR-588 
                 0 
               
               
                   
                 hsa-miR-589 
                 1443 
               
               
                   
                 hsa-miR-589* 
                 155 
               
               
                   
                 hsa-miR-590-3p 
                 5086 
               
               
                   
                 hsa-miR-590-5p 
                 11304 
               
               
                   
                 hsa-miR-591 
                 0 
               
               
                   
                 hsa-miR-592 
                 269 
               
               
                   
                 hsa-miR-593 
                 0 
               
               
                   
                 hsa-miR-593* 
                 0 
               
               
                   
                 hsa-miR-595 
                 0 
               
               
                   
                 hsa-miR-596 
                 0 
               
               
                   
                 hsa-miR-597 
                 33 
               
               
                   
                 hsa-miR-598 
                 10797 
               
               
                   
                 hsa-miR-599 
                 2 
               
               
                   
                 hsa-miR-600 
                 9 
               
               
                   
                 hsa-miR-601 
                 0 
               
               
                   
                 hsa-miR-602 
                 3 
               
               
                   
                 hsa-miR-603 
                 5 
               
               
                   
                 hsa-miR-604 
                 0 
               
               
                   
                 hsa-miR-605 
                 28 
               
               
                   
                 hsa-miR-606 
                 0 
               
               
                   
                 hsa-miR-607 
                 1 
               
               
                   
                 hsa-miR-608 
                 0 
               
               
                   
                 hsa-miR-609 
                 2 
               
               
                   
                 hsa-miR-610 
                 4 
               
               
                   
                 hsa-miR-611 
                 0 
               
               
                   
                 hsa-miR-612 
                 0 
               
               
                   
                 hsa-miR-613 
                 0 
               
               
                   
                 hsa-miR-614 
                 2 
               
               
                   
                 hsa-miR-615-3p 
                 341 
               
               
                   
                 hsa-miR-615-5p 
                 4 
               
               
                   
                 hsa-miR-616 
                 57 
               
               
                   
                 hsa-miR-616* 
                 196 
               
               
                   
                 hsa-miR-617 
                 0 
               
               
                   
                 hsa-miR-618 
                 356 
               
               
                   
                 hsa-miR-619 
                 0 
               
               
                   
                 hsa-miR-620 
                 0 
               
               
                   
                 hsa-miR-621 
                 0 
               
               
                   
                 hsa-miR-622 
                 10 
               
               
                   
                 hsa-miR-623 
                 0 
               
               
                   
                 hsa-miR-624 
                 47 
               
               
                   
                 hsa-miR-624* 
                 142 
               
               
                   
                 hsa-miR-625 
                 791 
               
               
                   
                 hsa-miR-625* 
                 1449 
               
               
                   
                 hsa-miR-626 
                 0 
               
               
                   
                 hsa-miR-627 
                 1704 
               
               
                   
                 hsa-miR-628-3p 
                 1869 
               
               
                   
                 hsa-miR-628-5p 
                 6569 
               
               
                   
                 hsa-miR-629 
                 1282 
               
               
                   
                 hsa-miR-629* 
                 187 
               
               
                   
                 hsa-miR-630 
                 0 
               
               
                   
                 hsa-miR-631 
                 0 
               
               
                   
                 hsa-miR-632 
                 2 
               
               
                   
                 hsa-miR-633 
                 0 
               
               
                   
                 hsa-miR-634 
                 0 
               
               
                   
                 hsa-miR-635 
                 0 
               
               
                   
                 hsa-miR-636 
                 6 
               
               
                   
                 hsa-miR-637 
                 0 
               
               
                   
                 hsa-miR-638 
                 0 
               
               
                   
                 hsa-miR-639 
                 3 
               
               
                   
                 hsa-miR-640 
                 0 
               
               
                   
                 hsa-miR-641 
                 122 
               
               
                   
                 hsa-miR-642 
                 81 
               
               
                   
                 hsa-miR-643 
                 69 
               
               
                   
                 hsa-miR-644 
                 0 
               
               
                   
                 hsa-miR-645 
                 0 
               
               
                   
                 hsa-miR-646 
                 0 
               
               
                   
                 hsa-miR-647 
                 0 
               
               
                   
                 hsa-miR-648 
                 0 
               
               
                   
                 hsa-miR-649 
                 0 
               
               
                   
                 hsa-miR-650 
                 3 
               
               
                   
                 hsa-miR-651 
                 1075 
               
               
                   
                 hsa-miR-652 
                 4967 
               
               
                   
                 hsa-miR-653 
                 479 
               
               
                   
                 hsa-miR-654-3p 
                 2161 
               
               
                   
                 hsa-miR-654-5p 
                 151 
               
               
                   
                 hsa-miR-655 
                 1774 
               
               
                   
                 hsa-miR-656 
                 274 
               
               
                   
                 hsa-miR-657 
                 0 
               
               
                   
                 hsa-miR-658 
                 1 
               
               
                   
                 hsa-miR-659 
                 2 
               
               
                   
                 hsa-miR-660 
                 3414 
               
               
                   
                 hsa-miR-661 
                 0 
               
               
                   
                 hsa-miR-662 
                 0 
               
               
                   
                 hsa-miR-663 
                 60 
               
               
                   
                 hsa-miR-663b 
                 44 
               
               
                   
                 hsa-miR-664 
                 3101 
               
               
                   
                 hsa-miR-664* 
                 2320 
               
               
                   
                 hsa-miR-665 
                 65 
               
               
                   
                 hsa-miR-668 
                 53 
               
               
                   
                 hsa-miR-670 
                 5 
               
               
                   
                 hsa-miR-671-3p 
                 92 
               
               
                   
                 hsa-miR-671-5p 
                 2990 
               
               
                   
                 hsa-miR-675 
                 71 
               
               
                   
                 hsa-miR-675* 
                 2472 
               
               
                   
                 hsa-miR-7 
                 66615 
               
               
                   
                 hsa-miR-708 
                 16305 
               
               
                   
                 hsa-miR-708* 
                 1017 
               
               
                   
                 hsa-miR-7-1* 
                 976 
               
               
                   
                 hsa-miR-711 
                 0 
               
               
                   
                 hsa-miR-718 
                 0 
               
               
                   
                 hsa-miR-7-2* 
                 86 
               
               
                   
                 hsa-miR-720 
                 2724 
               
               
                   
                 hsa-miR-744 
                 10452 
               
               
                   
                 hsa-miR-744* 
                 248 
               
               
                   
                 hsa-miR-758 
                 89 
               
               
                   
                 hsa-miR-759 
                 0 
               
               
                   
                 hsa-miR-760 
                 95 
               
               
                   
                 hsa-miR-761 
                 0 
               
               
                   
                 hsa-miR-762 
                 0 
               
               
                   
                 hsa-miR-764 
                 0 
               
               
                   
                 hsa-miR-765 
                 46 
               
               
                   
                 hsa-miR-766 
                 1204 
               
               
                   
                 hsa-miR-767-3p 
                 5 
               
               
                   
                 hsa-miR-767-5p 
                 72 
               
               
                   
                 hsa-miR-769-3p 
                 163 
               
               
                   
                 hsa-miR-769-5p 
                 11515 
               
               
                   
                 hsa-miR-770-5p 
                 26 
               
               
                   
                 hsa-miR-802 
                 486 
               
               
                   
                 hsa-miR-873 
                 305 
               
               
                   
                 hsa-miR-874 
                 2982 
               
               
                   
                 hsa-miR-875-3p 
                 0 
               
               
                   
                 hsa-miR-875-5p 
                 15 
               
               
                   
                 hsa-miR-876-3p 
                 25 
               
               
                   
                 hsa-miR-876-5p 
                 19 
               
               
                   
                 hsa-miR-877 
                 2724 
               
               
                   
                 hsa-miR-877* 
                 9 
               
               
                   
                 hsa-miR-885-3p 
                 173 
               
               
                   
                 hsa-miR-885-5p 
                 906 
               
               
                   
                 hsa-miR-886-3p 
                 168 
               
               
                   
                 hsa-miR-886-5p 
                 27435 
               
               
                   
                 hsa-miR-887 
                 1793 
               
               
                   
                 hsa-miR-888 
                 666 
               
               
                   
                 hsa-miR-888* 
                 7 
               
               
                   
                 hsa-miR-889 
                 3236 
               
               
                   
                 hsa-miR-890 
                 111 
               
               
                   
                 hsa-miR-891a 
                 4506 
               
               
                   
                 hsa-miR-891b 
                 94 
               
               
                   
                 hsa-miR-892a 
                 87 
               
               
                   
                 hsa-miR-892b 
                 49 
               
               
                   
                 hsa-miR-9 
                 165442 
               
               
                   
                 hsa-miR-9* 
                 29721 
               
               
                   
                 hsa-miR-920 
                 0 
               
               
                   
                 hsa-miR-921 
                 1 
               
               
                   
                 hsa-miR-922 
                 0 
               
               
                   
                 hsa-miR-924 
                 0 
               
               
                   
                 hsa-miR-92a 
                 85398 
               
               
                   
                 hsa-miR-92a-1* 
                 1103 
               
               
                   
                 hsa-miR-92a-2* 
                 6 
               
               
                   
                 hsa-miR-92b 
                 6766 
               
               
                   
                 hsa-miR-92b* 
                 391 
               
               
                   
                 hsa-miR-93 
                 95298 
               
               
                   
                 hsa-miR-93* 
                 475 
               
               
                   
                 hsa-miR-933 
                 2 
               
               
                   
                 hsa-miR-934 
                 1197 
               
               
                   
                 hsa-miR-935 
                 926 
               
               
                   
                 hsa-miR-936 
                 0 
               
               
                   
                 hsa-miR-937 
                 6 
               
               
                   
                 hsa-miR-938 
                 0 
               
               
                   
                 hsa-miR-939 
                 13 
               
               
                   
                 hsa-miR-940 
                 71 
               
               
                   
                 hsa-miR-941 
                 2312 
               
               
                   
                 hsa-miR-942 
                 172 
               
               
                   
                 hsa-miR-943 
                 3 
               
               
                   
                 hsa-miR-944 
                 3294 
               
               
                   
                 hsa-miR-95 
                 47301 
               
               
                   
                 hsa-miR-96 
                 3084 
               
               
                   
                 hsa-miR-96* 
                 2 
               
               
                   
                 hsa-miR-98 
                 43595 
               
               
                   
                 hsa-miR-99a 
                 314406 
               
               
                   
                 hsa-miR-99a* 
                 1328 
               
               
                   
                 hsa-miR-99b 
                 212576 
               
               
                   
                 hsa-miR-99b* 
                 900