Abstract:
The present invention relates to the use of forskolin and of the extracts containing it for the treatment of alcohol addiction.

Description:
BACKGROUND OF THE INVENTION 
     The present invention relates to pharmaceutical compositions for the treatment of alcohol addiction, characterized in that they contain--as the active principle--forskolin or extracts containing it. 
     Alcohol abuse and alcohol addiction, phenomena which can be collectively referred to by the term alcoholism, represent a serious problem for the whole of modern society (Gessa G. L., Bisogno compulsivo di bere e &#34;principio del piacere&#34;  The compulsive need to drink and the pleasure principle! in Medicina delle tossicodipendenze  Drug Addiction Medicine! II, 5 (1994)). In Italy, for example, more than 9% of the population (about 5 million people) are heavy drinkers and more than 1 million people are alcohol-addict (Calamo-Specchia F. P.--Epidemiologia dell&#39;alcolismo in Italia  Epidemiology of alcoholism in Italy! in Atti del VII Congresso Nazionale della S.I.A.,  Records of the 7th National Congress of the S.I.A.! Mediserve, Rome, 295-301, (1991)). These figures become much higher if we consider countries such as the United States of America where there are more than 13 million alcohol-addicts. Alcohol abuse and actual alcohol addiction result in an enormous outlay of public money (recently, since 1991, in the United States about 200 thousand million dollars a year have been spent) and are the cause of enormous social and psychological damage for the individuals involved. 
     The existing approaches for the treatment of alcoholism, in addition to those of a psychological nature (group therapy, etc.), consist in the use of drugs such as disulfiram and calcium carbamide which act on the metabolism of alcohol, inhibiting hepatic aldehyde-dehydrogenase and therefore raising the hematic levels of acetaldehyde, with all the undesiderable phenomena which occur each time ethanol is taken. 
     According to the present state of the art, the sole plant whose derivatives have been used for the treatment of alcoholism is the Pueraria lobata (Radix puerarie), which is widely used in traditional Chinese medicine and forms the subject of Patent Application WO 93/00896. 
     SUMMARY OF THE INVENTION 
     It has now been surprisingly found that forskolin can be used with success for reducing the voluntary consumption of alcohol and other drugs which induce addiction. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS 
     FIG. 1(a) and 1(b) is a graph showing the effect of treatment on alcohol and water consumption. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Forskolin, i.e. 17-β-acetoxy-8,13-epoxy-1α, 6β, 9α-trihydroxylabd-14-en-11-one, of formula: ##STR1## is a diterpenoid isolated from the plant Coleus forskohlii, native to India, which is capable of activating adenylate cyclase. 
     Its pharmacological activity is described by De Souza and Shah in Economic and Medicinal Plant Research vol. 2, H. Wagner, H. Hihino and N. Farusuworth ed., Academic Press. 1988. 
     The uses of forskolin in the treatment of cardiocirculatory and respiratory diseases and of glaucoma are known; for a review see, for example, the above cited reference; Seamon and Daly, Adv. Cyclic Nucleotide Res. 20, 1. 
     Determination of the inhibiting action on alcohol consumption was performed using alcohol-consuming rats of the strain called &#34;Sardinian alcohol-preferring&#34; (Sp) (Fadda P., Mosca E., Colombo G., Gessa G. L., Alcohol--preferrinq rats: Genetic sensitivity to alcohol--induced stimulation of dopamine metabolism, in Physiol. Behav. 47, 727 (1990)). 
     These animals, which given a free choice between alcohol and water consume daily 6 to 7 g of alcohol per kg of body weight (with a water-to-alcohol ratio higher than 2:1), during the last few years have been used with success to determine the effect of various substances on the voluntary consumption of alcohol; see, for example, Balakleevsky A., Colombo G., Fadda F., Gessa G. L., Ro 19-4603, a benzodiazepine receptor inverse agonist, attenuates voluntary ethanol consumption in rats selectively bred for hiah ethanol preference, in Alcohol Alcohol. 25, 449-452 (1990); Fadda F., Garau B., Colombo G., Gessa G. L., Isradipine and other calcium channel antagonists attenuate ethanol consumption in ethanol--preferring rats, in Alcoholism: Clinical and Experimental Research 16(3), 449-452 (1992). 
     The animals, which were kept under normal housing conditions, were given a free choice between water (which was always present) and alcohol (a 10% solution v/v) which was offered for a period of 4 hours a day (i.e. the first 4 hours of darkness during the day/night cycle). The amounts of water and alcohol consumed were recorded every day at the same time. Food was offered ad libitum. Once a stable consumption of alcohol and water was reached, forskolin at a dosage of 50 mg/kg, dissolved in dimethylsulfoxide, was administered orally in a volume amount of 2 ml/kg once a day for 7 consecutive days. An equal volume of the carrier was used as the control. At the end of treatment, the alcohol and water consumption was recorded until the values recorded prior to the treatment were re-established. 
     FIG. 1A shows the effect of repeated oral administration of 50 mg/kg of forskolin on alcohol consumption; FIG. 1B shows the effect on water consumption. 
     From an examination of FIG. 1 it can be concluded that forskolin reduces alcohol consumption significantly. The reduction in alcohol consumption remains constant until the seventh day and then regresses following suspension of the treatment. Moreover, it is surprising to note that this trend is accompanied by the tendency for a gradual increase in the water consumption, as if the animal were substituting it for the alcohol. This latter observation is of particular importance since it shows that the treatment carried out with the product being tested is perfectly well-tolerated and the animal returns without any difficulty to a more physiological life cycle, using water instead of alcohol. 
     The invention therefore provides pharmaceutical compositions which can be administered orally and which contain as the active principle forskolin. The compositions of the invention, in addition to conventional excipients or carriers, will contain from about 10 to about 500 mg of the active principle. 
     EXAMPLE 1 
     Sachet formulation 
     Each 2,300 mg sachet contains: 
     Forskolin 100 mg 
     Saccharose 2,000 mg 
     Maltodextrin 110 mg 
     Citric acid 30 mg 
     Orange flavor 40 mg 
     Hydrogenated vegetable oils 20 mg 
     EXAMPLE 2 
     Tablet formulation 
     Each 100 mg tablet contains: 
     Forskolin 25 mg 
     Microcrystalline cellulose 25 mg 
     Lactose 37 mg 
     Colloidal silica 1 mg 
     Cross-linked sodium carboxymethylcellulose 6 mg 
     Polyvinylpyrrolidone 5 mg 
     Magnesium stearate 1 mg