Abstract:
The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application is a continuation of U.S. patent application Ser. No. 13/078,606, entitled “Method of Forming An Aerosol For Inhalation Delivery,” filed Apr. 1, 2011, which is a continuation of U.S. patent application Ser. No. 12/471,070, entitled “Method of Forming An Aerosol For Inhalation Delivery,” filed May 22, 2009, now U.S. Pat. No. 8,074,644, which is a continuation of U.S. patent application Ser. No. 10/146,088, entitled “Method Of Forming An Aerosol For Inhalation Delivery,” filed May 13, 2002, now U.S. Pat. No. 7,537,009, which is a continuation-in-part of U.S. patent application Ser. No. 10/057,198 entitled “Method and Device for Delivering a Physiologically Active Compound,” filed Oct. 26, 2001, and of U.S. patent application Ser. No. 10/057,197 entitled “Aerosol Generating Device and Method,” filed Oct. 26, 2001, now U.S. Pat. No. 7,766,013, each of which further claims priority to U.S. Provisional Application Ser. No. 60/296,225 entitled “Aerosol Generating Device and Method,” filed Jun. 5, 2001, the entire disclosures of which are hereby incorporated by reference. Any disclaimer that may have occurred during the prosecution of the above-referenced applications is hereby expressly rescinded, and reconsideration of all relevant art is respectfully requested. 
     
    
     FIELD OF THE INVENTION 
       [0002]    The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. 
       BACKGROUND OF THE INVENTION 
       [0003]    Currently, there are a number of approved devices for the inhalation delivery of drugs, including dry powder inhalers, nebulizers, and pressurized metered dose inhalers. The aerosols produced by the devices, however, typically contain an excipient. 
         [0004]    It is desirable to provide a method that can produce aerosols in the absence of excipients. The provision of such a device is an object of the present invention. 
       SUMMARY OF THE INVENTION 
       [0005]    The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. 
         [0006]    In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. Preferably, the substrate is heated at a rate greater than 2,000° C./s, 5,000° C./s, 7,500° C./s, or 10,000° C./s. 
         [0007]    In certain cases, the substrate is heated at a rate of about 2,000° C./s. 
         [0008]    Typically, the composition is coated on the substrate as a film that is less than 10μ thick. Preferably, the film thickness is less than 5μ, 4μ, 3μ, 2μ, or 1μ thick. 
         [0009]    Typically, the composition is coated on the substrate as a film that is between 10μ and 10 nm in thickness. Preferably, the film thickness is between 5μ and 10 nm, 4μ and 10 nm, 3μ and 10 nm, 2μ and 10 nm, or 1μ and 10 nm in thickness. 
         [0010]    Typically, greater than 0.1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating. Preferably, 0.25 mg, 0.5 mg, 0.75 mg, or 1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating. More preferably, the same amount of composition list above is vaporized in less than 75 milliseconds, 50 milliseconds, 25 milliseconds, or 10 milliseconds from the start of heating. 
         [0011]    Typically, the formed aerosol is greater than 10 percent by weight of the drug. Preferably, it is greater than 20 percent by weight of the drug. More preferably, it is greater than 30 percent, 40 percent, 50 percent, 60 percent, 70 percent, 80 percent, 90 percent, 95 percent or 97 percent by weight of the drug. 
         [0012]    Typically, the formed aerosol contains less than 10 percent by weight of drug decomposition products. Preferably, it contains less than 5 percent by weight of drug decomposition products. More preferably, it contains less than 3 percent, 2 percent or 1 percent by weight of drug decomposition products. 
         [0013]    Typically, the drug has a decomposition index less than 0.15. Preferably, the drug has a decomposition index less than 0.10. More preferably, the drug has a decomposition index less than 0.05. 
         [0014]    Typically, the drug of the composition is of one of the following classes: antibiotics, anticonvulsants, antidepressants, antiemetics, antihistamines, antiparkisonian drugs, antipsychotics, anxiolytics, drugs for erectile dysfunction, drugs for migraine headaches, drugs for the treatment of alcoholism, drugs for the treatment of addiction, muscle relaxants, nonsteroidal anti-inflammatories, opioids, other analgesics and stimulants. 
         [0015]    Typically, where the drug is an antibiotic, it is selected from one of the following compounds: cefmetazole; cefazolin; cephalexin; cefoxitin; cephacetrile; cephaloglycin; cephaloridine; cephalosporins, such as cephalosporin C; cephalotin; cephamycins, such as cephamycin A, cephamycin B, and cephamycin C; cepharin; cephradine; ampicillin; amoxicillin; hetacillin; carfecillin; carindacillin; carbenicillin; amylpenicillin; azidocillin; benzylpenicillin; clometocillin; cloxacillin; cyclacillin; methicillin; nafcillin; 2-pentenylpenicillin; penicillins, such as penicillin N, penicillin O, penicillin S, penicillin V; chlorobutin penicillin; dicloxacillin; diphenicillin; heptylpenicillin; and metampicillin. 
         [0016]    Typically, where the drug is an anticonvulsant, it is selected from one of the following compounds: gabapentin, tiagabine, and vigabatrin. 
         [0017]    Typically, where the drug is an antidepressant, it is selected from one of the following compounds: amitriptyline, amoxapine, benmoxine, butriptyline, clomipramine, desipramine, dosulepin, doxepin, imipramine, kitanserin, lofepramine, medifoxamine, mianserin, maprotoline, mirtazapine, nortriptyline, protriptyline, trimipramine, viloxazine, citalopram, cotinine, duloxetine, fluoxetine, fluvoxamine, milnacipran, nisoxetine, paroxetine, reboxetine, sertraline, tianeptine, acetaphenazine, binedaline, brofaromine, cericlamine, clovoxamine, iproniazid, isocarboxazid, moclobemide, phenyhydrazine, phenelzine, selegiline, sibutramine, tranylcypromine, ademetionine, adrafinil, amesergide, amisulpride, amperozide, benactyzine, bupropion, caroxazone, gepirone, idazoxan, metralindole, milnacipran, minaprine, nefazodone, nomifensine, ritanserin, roxindole, S-adenosylmethionine, tofenacin, trazodone, tryptophan, venlafaxine, and zalospirone. 
         [0018]    Typically, where the drug is an antiemetic, it is selected from one of the following compounds: alizapride, azasetron, benzquinamide, bromopride, buclizine, chlorpromazine, cinnarizine, clebopride, cyclizine, diphenhydramine, diphenidol, dolasetron methanesulfonate, droperidol, granisetron, hyoscine, lorazepam, metoclopramide, metopimazine, ondansetron, perphenazine, promethazine, prochlorperazine, scopolamine, triethylperazine, trifluoperazine, triflupromazine, trimethobenzamide, tropisetron, domeridone, and palonosetron. 
         [0019]    Typically, where the drug is an antihistamine, it is selected from one of the following compounds: azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexmedetomidine, diphenhydramine, doxylamine, hydroxyzine, cetrizine, fexofenadine, loratidine, and promethazine. 
         [0020]    Typically, where the drug is an antiparkisonian drug, it is selected one of the following compounds: amantadine, baclofen, biperiden, benztropine, orphenadrine, procyclidine, trihexyphenidyl, levodopa, carbidopa, selegiline, deprenyl, andropinirole, apomorphine, benserazide, bromocriptine, budipine, cabergoline, dihydroergokryptine, eliprodil, eptastigmine, ergoline pramipexole, galanthamine, lazabemide, lisuride, mazindol, memantine, mofegiline, pergolike, pramipexole, propentofylline, rasagiline, remacemide, spheramine, terguride, entacapone, and tolcapone. 
         [0021]    Typically, where the drug is an antipsychotic, it is selected from one of the following compounds: acetophenazine, alizapride, amperozide, benperidol, benzquinamide, bromperidol, buramate, butaperazine, carphenazine, carpipramine, chlorpromazine, chlorprothixene, clocapramine, clomacran, clopenthixol, clospirazine, clothiapine, cyamemazine, droperidol, flupenthixol, fluphenazine, fluspirilene, haloperidol, mesoridazine, metofenazate, molindrone, penfluridol, pericyazine, perphenazine, pimozide, pipamerone, piperacetazine, pipotiazine, prochlorperazine, promazine, remoxipride, sertindole, spiperone, sulpiride, thioridazine, thiothixene, trifluperidol, triflupromazine, trifluoperazine, ziprasidone, zotepine, zuclopenthixol, amisulpride, butaclamol, clozapine, melperone, olanzapine, quetiapine, and risperidone. 
         [0022]    Typically, where the drug is an anxiolytic, it is selected from one of the following compounds: mecloqualone, medetomidine, metomidate, adinazolam, chlordiazepoxide, clobenzepam, flurazepam, lorazepam, loprazolam, midazolam, alpidem, alseroxlon, amphenidone, azacyclonol, bromisovalum, buspirone, calcium N-carboamoylaspartate, captodiamine, capuride, carbcloral, carbromal, chloral betaine, enciprazine, flesinoxan, ipsapiraone, lesopitron, loxapine, methaqualone, methprylon, propanolol, tandospirone, trazadone, zopiclone, and zolpidem. 
         [0023]    Typically, where the drug is a drug for erectile dysfunction, it is selected from one of the following compounds: cialis (IC351), sildenafil, vardenafil, apomorphine, apomorphine diacetate, phentolamine, and yohimbine. 
         [0024]    Typically, where the drug is a drug for migraine headache, it is selected from one of the following compounds: almotriptan, alperopride, codeine, dihydroergotamine, ergotamine, eletriptan, frovatriptan, isometheptene, lidocaine, lisuride, metoclopramide, naratriptan, oxycodone, propoxyphene, rizatriptan, sumatriptan, tolfenamic acid, zolmitriptan, amitriptyline, atenolol, clonidine, cyproheptadine, diltiazem, doxepin, fluoxetine, lisinopril, methysergide, metoprolol, nadolol, nortriptyline, paroxetine, pizotifen, pizotyline, propanolol, protriptyline, sertraline, timolol, and verapamil. 
         [0025]    Typically, where the drug is a drug for the treatment of alcoholism, it is selected from one of the following compounds: naloxone, naltrexone, and disulfuram. 
         [0026]    Typically, where the drug is a drug for the treatment of addiction it is buprenorphine. 
         [0027]    Typically, where the drug is a muscle relaxant, it is selected from one of the following compounds: baclofen, cyclobenzaprine, orphenadrine, quinine, and tizanidine. 
         [0028]    Typically, where the drug is a nonsteroidal anti-inflammatory, it is selected from one of the following compounds: aceclofenac, alminoprofen, amfenac, aminopropylon, amixetrine, benoxaprofen, bromfenac, bufexamac, carprofen, choline, salicylate, cinchophen, cinmetacin, clopriac, clometacin, diclofenac, etodolac, indoprofen, mazipredone, meclofenamate, piroxicam, pirprofen, and tolfenamate. 
         [0029]    Typically, where the drug is an opioid, it is selected from one of the following compounds: alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, carbiphene, cipramadol, clonitazene, codeine, dextromoramide, dextropropoxyphene, diamorphine, dihydrocodeine, diphenoxylate, dipipanone, fentanyl, hydromorphone, L-alpha acetyl methadol, lofentanil, levorphanol, meperidine, methadone, meptazinol, metopon, morphine, nalbuphine, nalorphine, oxycodone, papavereturn, pethidine, pentazocine, phenazocine, remifentanil, sufentanil, and tramadol. 
         [0030]    Typically, where the drug is an other analgesic it is selected from one of the following compounds: apazone, benzpiperylon, benzydramine, caffeine, clonixin, ethoheptazine, flupirtine, nefopam, orphenadrine, propacetamol, and propoxyphene. 
         [0031]    Typically, where the drug is a stimulant, it is selected from one of the following compounds: amphetamine, brucine, caffeine, dexfenfluramine, dextroamphetamine, ephedrine, fenfluramine, mazindol, methyphenidate, pemoline, phentermine, and sibutramine. 
         [0032]    In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. Preferably, the film thickness is less than 5μ, 4μ, 3μ, 2μ, or 1μ thick. 
         [0033]    Typically, the composition is coated on the substrate as a film that is between 10μ and 10 nm in thickness. Preferably, the film thickness is between 5μ, and 10 nm, 4μ, and 10 nm, 3μ and 10 nm, 2μ and 10 nm, or 1μ and 10 nm in thickness. 
         [0034]    Typically, greater than 0.1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating. Preferably, 0.25 mg, 0.5 mg, 0.75 mg, or 1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating. More preferably, the same amount of composition list above is vaporized in less than 75 milliseconds, 50 milliseconds, 25 milliseconds, or 10 milliseconds from the start of heating. 
         [0035]    Typically, the formed aerosol is greater than 10 percent by weight of the drug. Preferably, it is greater than 20 percent by weight of the drug. More preferably, it is greater than 30 percent, 40 percent, 50 percent, 60 percent, 70 percent, 80 percent, 90 percent, 95 percent or 97 percent by weight of the drug. 
         [0036]    Typically, the formed aerosol contains less than 10 percent by weight of drug decomposition products. Preferably, it contains less than 5 percent by weight of drug decomposition products. More preferably, it contains less than 3 percent, 2 percent or 1 percent by weight of drug decomposition products. 
         [0037]    Typically, the drug has a decomposition index less than 0.15. Preferably, the drug has a decomposition index less than 0.10. More preferably, the drug has a decomposition index less than 0.05. 
         [0038]    Typically, the drug of the composition is of one of the following classes: antibiotics, anticonvulsants, antidepressants, antiemetics, antihistamines, antiparkisonian drugs, antipsychotics, anxiolytics, drugs for erectile dysfunction, drugs for migraine headaches, drugs for the treatment of alcoholism, drugs for the treatment of addiction, muscle relaxants, nonsteroidal anti-inflammatories, opioids, other analgesics and stimulants. 
         [0039]    Typically, where the drug is an antibiotic, it is selected from one of the following compounds: cefmetazole; cefazolin; cephalexin; cefoxitin; cephacetrile; cephaloglycin; cephaloridine; cephalosporins, such as cephalosporin C; cephalotin; cephamycins, such as cephamycin A, cephamycin B, and cephamycin C; cepharin; cephradine; ampicillin; amoxicillin; hetacillin; carfecillin; carindacillin; carbenicillin; amylpenicillin; azidocillin; benzylpenicillin; clometocillin; cloxacillin; cyclacillin; methicillin; nafcillin; 2-pentenylpenicillin; penicillins, such as penicillin N, penicillin O, penicillin S, penicillin V; chlorobutin penicillin; dicloxacillin; diphenicillin; heptylpenicillin; and metampicillin. 
         [0040]    Typically, where the drug is an anticonvulsant, it is selected from one of the following compounds: gabapentin, tiagabine, and vigabatrin. 
         [0041]    Typically, where the drug is an antidepressant, it is selected from one of the following compounds: amitriptyline, amoxapine, benmoxine, butriptyline, clomipramine, desipramine, dosulepin, doxepin, imipramine, kitanserin, lofepramine, medifoxamine, mianserin, maprotoline, mirtazapine, nortriptyline, protriptyline, trimipramine, viloxazine, citalopram, cotinine, duloxetine, fluoxetine, fluvoxamine, milnacipran, nisoxetine, paroxetine, reboxetine, sertraline, tianeptine, acetaphenazine, binedaline, brofaromine, cericlamine, clovoxamine, iproniazid, isocarboxazid, moclobemide, phenyhydrazine, phenelzine, selegiline, sibutramine, tranylcypromine, ademetionine, adrafinil, amesergide, amisulpride, amperozide, benactyzine, bupropion, caroxazone, gepirone, idazoxan, metralindole, milnacipran, minaprine, nefazodone, nomifensine, ritanserin, roxindole, S-adenosylmethionine, tofenacin, trazodone, tryptophan, venlafaxine, and zalospirone. 
         [0042]    Typically, where the drug is an antiemetic, it is selected from one of the following compounds: alizapride, azasetron, benzquinamide, bromopride, buclizine, chlorpromazine, cinnarizine, clebopride, cyclizine, diphenhydramine, diphenidol, dolasetron methanesulfonate, droperidol, granisetron, hyoscine, lorazepam, metoclopramide, metopimazine, ondansetron, perphenazine, promethazine, prochlorperazine, scopolamine, triethylperazine, trifluoperazine, triflupromazine, trimethobenzamide, tropisetron, domeridone, and palonosetron. 
         [0043]    Typically, where the drug is an antihistamine, it is selected from one of the following compounds: azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexmedetomidine, diphenhydramine, doxylamine, hydroxyzine, cetrizine, fexofenadine, loratidine, and promethazine. 
         [0044]    Typically, where the drug is an antiparkisonian drug, it is selected one of the following compounds: amantadine, baclofen, biperiden, benztropine, orphenadrine, procyclidine, trihexyphenidyl, levodopa, carbidopa, selegiline, deprenyl, andropinirole, apomorphine, benserazide, bromocriptine, budipine, cabergoline, dihydroergokryptine, eliprodil, eptastigmine, ergoline pramipexole, galanthamine, lazabemide, lisuride, mazindol, memantine, mofegiline, pergolike, pramipexole, propentofylline, rasagiline, remacemide, spheramine, terguride, entacapone, and tolcapone. 
         [0045]    Typically, where the drug is an antipsychotic, it is selected from one of the following compounds: acetophenazine, alizapride, amperozide, benperidol, benzquinamide, bromperidol, buramate, butaperazine, carphenazine, carpipramine, chlorpromazine, chlorprothixene, clocapramine, clomacran, clopenthixol, clospirazine, clothiapine, cyamemazine, droperidol, flupenthixol, fluphenazine, fluspirilene, haloperidol, mesoridazine, metofenazate, molindrone, penfluridol, pericyazine, perphenazine, pimozide, pipamerone, piperacetazine, pipotiazine, prochlorperazine, promazine, remoxipride, sertindole, spiperone, sulpiride, thioridazine, thiothixene, trifluperidol, triflupromazine, trifluoperazine, ziprasidone, zotepine, zuclopenthixol, amisulpride, butaclamol, clozapine, melperone, olanzapine, quetiapine, and risperidone. 
         [0046]    Typically, where the drug is an anxiolytic, it is selected from one of the following compounds: mecloqualone, medetomidine, metomidate, adinazolam, chlordiazepoxide, clobenzepam, flurazepam, lorazepam, loprazolam, midazolam, alpidem, alseroxlon, amphenidone, azacyclonol, bromisovalum, buspirone, calcium N-carboamoylaspartate, captodiamine, capuride, carbcloral, carbromal, chloral betaine, enciprazine, flesinoxan, ipsapiraone, lesopitron, loxapine, methaqualone, methprylon, propanolol, tandospirone, trazadone, zopiclone, and zolpidem. 
         [0047]    Typically, where the drug is a drug for erectile dysfunction, it is selected from one of the following compounds: cialis (IC351), sildenafil, vardenafil, apomorphine, apomorphine diacetate, phentolamine, and yohimbine. 
         [0048]    Typically, where the drug is a drug for migraine headache, it is selected from one of the following compounds: almotriptan, alperopride, codeine, dihydroergotamine, ergotamine, eletriptan, frovatriptan, isometheptene, lidocaine, lisuride, metoclopramide, naratriptan, oxycodone, propoxyphene, rizatriptan, sumatriptan, tolfenamic acid, zolmitriptan, amitriptyline, atenolol, clonidine, cyproheptadine, diltiazem, doxepin, fluoxetine, lisinopril, methysergide, metoprolol, nadolol, nortriptyline, paroxetine, pizotifen, pizotyline, propanolol, protriptyline, sertraline, timolol, and verapamil. 
         [0049]    Typically, where the drug is a drug for the treatment of alcoholism, it is selected from one of the following compounds: naloxone, naltrexone, and disulfuram. 
         [0050]    Typically, where the drug is a drug for the treatment of addiction it is buprenorphine. 
         [0051]    Typically, where the drug is a muscle relaxant, it is selected from one of the following compounds: baclofen, cyclobenzaprine, orphenadrine, quinine, and tizanidine. 
         [0052]    Typically, where the drug is a nonsteroidal anti-inflammatory, it is selected from one of the following compounds: aceclofenac, alminoprofen, amfenac, aminopropylon, amixetrine, benoxaprofen, bromfenac, bufexamac, carprofen, choline, salicylate, cinchophen, cinmetacin, clopriac, clometacin, diclofenac, etodolac, indoprofen, mazipredone, meclofenamate, piroxicam, pirprofen, and tolfenamate. 
         [0053]    Typically, where the drug is an opioid, it is selected from one of the following compounds: alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, carbiphene, cipramadol, clonitazene, codeine, dextromoramide, dextropropoxyphene, diamorphine, dihydrocodeine, diphenoxylate, dipipanone, fentanyl, hydromorphone, L-alpha acetyl methadol, lofentanil, levorphanol, meperidine, methadone, meptazinol, metopon, morphine, nalbuphine, nalorphine, oxycodone, papavereturn, pethidine, pentazocine, phenazocine, remifentanil, sufentanil, and tramadol. 
         [0054]    Typically, where the drug is an other analgesic it is selected from one of the following compounds: apazone, benzpiperylon, benzydramine, caffeine, clonixin, ethoheptazine, flupirtine, nefopam, orphenadrine, propacetamol, and propoxyphene. 
         [0055]    Typically, where the drug is a stimulant, it is selected from one of the following compounds: amphetamine, brucine, caffeine, dexfenfluramine, dextroamphetamine, ephedrine, fenfluramine, mazindol, methyphenidate, pemoline, phentermine, and sibutramine. 
         [0056]    In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. Preferably, 0.25 mg, 0.5 mg, 0.75 mg, or 1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating. More preferably, the same amount of composition list above is vaporized in less than 75 milliseconds, 50 milliseconds, 25 milliseconds, or 10 milliseconds from the start of heating. 
         [0057]    Typically, the formed aerosol is greater than 10 percent by weight of the drug. Preferably, it is greater than 20 percent by weight of the drug. More preferably, it is greater than 30 percent, 40 percent, 50 percent, 60 percent, 70 percent, 80 percent, 90 percent, 95 percent or 97 percent by weight of the drug. 
         [0058]    Typically, the formed aerosol contains less than 10 percent by weight of drug decomposition products. Preferably, it contains less than 5 percent by weight of drug decomposition products. More preferably, it contains less than 3 percent, 2 percent or 1 percent by weight of drug decomposition products. 
         [0059]    Typically, the drug has a decomposition index less than 0.15. Preferably, the drug has a decomposition index less than 0.10. More preferably, the drug has a decomposition index less than 0.05. 
         [0060]    Typically, the drug of the composition is of one of the following classes: antibiotics, anticonvulsants, antidepressants, antiemetics, antihistamines, antiparkisonian drugs, antipsychotics, anxiolytics, drugs for erectile dysfunction, drugs for migraine headaches, drugs for the treatment of alcoholism, drugs for the treatment of addiction, muscle relaxants, nonsteroidal anti-inflammatories, opioids, other analgesics and stimulants. 
         [0061]    Typically, where the drug is an antibiotic, it is selected from one of the following compounds: cefmetazole; cefazolin; cephalexin; cefoxitin; cephacetrile; cephaloglycin; cephaloridine; cephalosporins, such as cephalosporin C; cephalotin; cephamycins, such as cephamycin A, cephamycin B, and cephamycin C; cepharin; cephradine; ampicillin; amoxicillin; hetacillin; carfecillin; carindacillin; carbenicillin; amylpenicillin; azidocillin; benzylpenicillin; clometocillin; cloxacillin; cyclacillin; methicillin; nafcillin; 2-pentenylpenicillin; penicillins, such as penicillin N, penicillin O, penicillin S, penicillin V; chlorobutin penicillin; dicloxacillin; diphenicillin; heptylpenicillin; and metampicillin. 
         [0062]    Typically, where the drug is an anticonvulsant, it is selected from one of the following compounds: gabapentin, tiagabine, and vigabatrin. 
         [0063]    Typically, where the drug is an antidepressant, it is selected from one of the following compounds: amitriptyline, amoxapine, benmoxine, butriptyline, clomipramine, desipramine, dosulepin, doxepin, imipramine, kitanserin, lofepramine, medifoxamine, mianserin, maprotoline, mirtazapine, nortriptyline, protriptyline, trimipramine, viloxazine, citalopram, cotinine, duloxetine, fluoxetine, fluvoxamine, milnacipran, nisoxetine, paroxetine, reboxetine, sertraline, tianeptine, acetaphenazine, binedaline, brofaromine, cericlamine, clovoxamine, iproniazid, isocarboxazid, moclobemide, phenyhydrazine, phenelzine, selegiline, sibutramine, tranylcypromine, ademetionine, adrafinil, amesergide, amisulpride, amperozide, benactyzine, bupropion, caroxazone, gepirone, idazoxan, metralindole, milnacipran, minaprine, nefazodone, nomifensine, ritanserin, roxindole, S-adenosylmethionine, tofenacin, trazodone, tryptophan, venlafaxine, and zalospirone. 
         [0064]    Typically, where the drug is an antiemetic, it is selected from one of the following compounds: alizapride, azasetron, benzquinamide, bromopride, buclizine, chlorpromazine, cinnarizine, clebopride, cyclizine, diphenhydramine, diphenidol, dolasetron methanesulfonate, droperidol, granisetron, hyoscine, lorazepam, metoclopramide, metopimazine, ondansetron, perphenazine, promethazine, prochlorperazine, scopolamine, triethylperazine, trifluoperazine, triflupromazine, trimethobenzamide, tropisetron, domeridone, and palonosetron. 
         [0065]    Typically, where the drug is an antihistamine, it is selected from one of the following compounds: azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexmedetomidine, diphenhydramine, doxylamine, hydroxyzine, cetrizine, fexofenadine, loratidine, and promethazine. 
         [0066]    Typically, where the drug is an antiparkisonian drug, it is selected one of the following compounds: amantadine, baclofen, biperiden, benztropine, orphenadrine, procyclidine, trihexyphenidyl, levodopa, carbidopa, selegiline, deprenyl, andropinirole, apomorphine, benserazide, bromocriptine, budipine, cabergoline, dihydroergokryptine, eliprodil, eptastigmine, ergoline pramipexole, galanthamine, lazabemide, lisuride, mazindol, memantine, mofegiline, pergolike, pramipexole, propentofylline, rasagiline, remacemide, spheramine, terguride, entacapone, and tolcapone. 
         [0067]    Typically, where the drug is an antipsychotic, it is selected from one of the following compounds: acetophenazine, alizapride, amperozide, benperidol, benzquinamide, bromperidol, buramate, butaperazine, carphenazine, carpipramine, chlorpromazine, chlorprothixene, clocapramine, clomacran, clopenthixol, clospirazine, clothiapine, cyamemazine, droperidol, flupenthixol, fluphenazine, fluspirilene, haloperidol, mesoridazine, metofenazate, molindrone, penfluridol, pericyazine, perphenazine, pimozide, pipamerone, piperacetazine, pipotiazine, prochlorperazine, promazine, remoxipride, sertindole, spiperone, sulpiride, thioridazine, thiothixene, trifluperidol, triflupromazine, trifluoperazine, ziprasidone, zotepine, zuclopenthixol, amisulpride, butaclamol, clozapine, melperone, olanzapine, quetiapine, and risperidone. 
         [0068]    Typically, where the drug is an anxiolytic, it is selected from one of the following compounds: mecloqualone, medetomidine, metomidate, adinazolam, chlordiazepoxide, clobenzepam, flurazepam, lorazepam, loprazolam, midazolam, alpidem, alseroxlon, amphenidone, azacyclonol, bromisovalum, buspirone, calcium N-carboamoylaspartate, captodiamine, capuride, carbcloral, carbromal, chloral betaine, enciprazine, flesinoxan, ipsapiraone, lesopitron, loxapine, methaqualone, methprylon, propanolol, tandospirone, trazadone, zopiclone, and zolpidem. 
         [0069]    Typically, where the drug is a drug for erectile dysfunction, it is selected from one of the following compounds: cialis (IC351), sildenafil, vardenafil, apomorphine, apomorphine diacetate, phentolamine, and yohimbine. 
         [0070]    Typically, where the drug is a drug for migraine headache, it is selected from one of the following compounds: almotriptan, alperopride, codeine, dihydroergotamine, ergotamine, eletriptan, frovatriptan, isometheptene, lidocaine, lisuride, metoclopramide, naratriptan, oxycodone, propoxyphene, rizatriptan, sumatriptan, tolfenamic acid, zolmitriptan, amitriptyline, atenolol, clonidine, cyproheptadine, diltiazem, doxepin, fluoxetine, lisinopril, methysergide, metoprolol, nadolol, nortriptyline, paroxetine, pizotifen, pizotyline, propanolol, protriptyline, sertraline, timolol, and verapamil. 
         [0071]    Typically, where the drug is a drug for the treatment of alcoholism, it is selected from one of the following compounds: naloxone, naltrexone, and disulfuram. 
         [0072]    Typically, where the drug is a drug for the treatment of addiction it is buprenorphine. 
         [0073]    Typically, where the drug is a muscle relaxant, it is selected from one of the following compounds: baclofen, cyclobenzaprine, orphenadrine, quinine, and tizanidine. 
         [0074]    Typically, where the drug is a nonsteroidal anti-inflammatory, it is selected from one of the following compounds: aceclofenac, alminoprofen, amfenac, aminopropylon, amixetrine, benoxaprofen, bromfenac, bufexamac, carprofen, choline, salicylate, cinchophen, cinmetacin, clopriac, clometacin, diclofenac, etodolac, indoprofen, mazipredone, meclofenamate, piroxicam, pirprofen, and tolfenamate. 
         [0075]    Typically, where the drug is an opioid, it is selected from one of the following compounds: alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, carbiphene, cipramadol, clonitazene, codeine, dextromoramide, dextropropoxyphene, diamorphine, dihydrocodeine, diphenoxylate, dipipanone, fentanyl, hydromorphone, L-alpha acetyl methadol, lofentanil, levorphanol, meperidine, methadone, meptazinol, metopon, morphine, nalbuphine, nalorphine, oxycodone, papavereturn, pethidine, pentazocine, phenazocine, remifentanil, sufentanil, and tramadol. 
         [0076]    Typically, where the drug is an other analgesic it is selected from one of the following compounds: apazone, benzpiperylon, benzydramine, caffeine, clonixin, ethoheptazine, flupirtine, nefopam, orphenadrine, propacetamol, and propoxyphene. 
         [0077]    Typically, where the drug is a stimulant, it is selected from one of the following compounds: amphetamine, brucine, caffeine, dexfenfluramine, dextroamphetamine, ephedrine, fenfluramine, mazindol, methyphenidate, pemoline, phentermine, and sibutramine. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0078]    Further features and advantages will become apparent from the following description of various examples of the invention, as illustrated in the accompanying drawings in which: 
           [0079]      FIG. 1  is a schematic diagram of the overall system for conducting experiments using a laboratory example of a device of the present invention; 
           [0080]      FIG. 2  is a top, right end and front perspective view of the example depicted in  FIG. 1 ; 
           [0081]      FIG. 3  is a partial cross-sectional and partial schematic side view of the example shown in  FIG. 2 ; 
           [0082]      FIG. 4  is a partial cross-sectional and partial schematic end view of the example shown in  FIG. 2 ; 
           [0083]      FIG. 5  is a partial cross-sectional and partial schematic top view of the example shown in  FIG. 2 ; 
           [0084]      FIG. 6  is a schematic cross-sectional side view of an alternate example of the device of the present invention using an annunciating device; 
           [0085]      FIG. 7  is a top, left end and front perspective views of the removable sub-assembly containing the compound and a movable slide of the example shown in  FIG. 2  showing the sub-assembly being mounted within the slide; 
           [0086]      FIG. 8  is a schematic view of the heating element of the example shown in  FIG. 2  showing the electric drive circuit; 
           [0087]      FIG. 9  is a schematic side view of a second example of the present invention using a venturi tube; 
           [0088]      FIG. 10  is a schematic side view of a fourth example of the present invention using a thin-walled tube coated with the compound; 
           [0089]      FIG. 11  is a schematic side end view of the example shown in  FIG. 10 ; 
           [0090]      FIG. 12  is a schematic side end view of the example shown in  FIG. 10  showing an inductive heating system generating an alternating magnetic field; 
           [0091]      FIG. 13  is a schematic side view of an alternate example of that shown in  FIG. 10  using a flow restrictor within the thin-walled tube; 
           [0092]      FIG. 14  is a schematic side view of a fifth example of the present invention using an expandable container for the compound; 
           [0093]      FIG. 15  is a schematic side view of a sixth example of the present invention using a container for the compound in an inert atmosphere; 
           [0094]      FIG. 16  is a schematic side view of the example shown in  FIG. 15  using a re-circulation of the inert atmosphere over the compound&#39;s surface; 
           [0095]      FIG. 17  is a schematic side view of a seventh example of the present invention using a tube containing particles coated with the compound; 
           [0096]      FIG. 18  is a schematic side view of the example shown in  FIG. 17  using a heating system to heat the gas passing over the coated particles; 
           [0097]      FIG. 19  is a schematic side view of an eighth example of the present invention referred to herein as the “oven device”; 
           [0098]      FIG. 20  is a schematic side view of an ninth example of the present invention using gradient heating; 
           [0099]      FIG. 21  is a schematic side view of a tenth example of the present invention using a fine mesh screen coated with the compound; 
           [0100]      FIG. 22  is a top, right end and front perspective view of the example shown in  FIG. 21 ; 
           [0101]      FIG. 23  is a plot of the rate of aggregation of smaller particles into larger ones; 
           [0102]      FIG. 24  is a plot of the coagulation coefficient (K) versus particle size of the compound; 
           [0103]      FIG. 25  is a plot of vapor pressure of various compounds, e.g., diphenyl ether, hexadecane, geranyl formate and caproic acid, versus temperature; 
           [0104]      FIG. 26  is a plot of blood levels for both the IV dose and the inhalation dose administered to various dogs during the experiments using the system shown in  FIG. 1 ; 
           [0105]      FIG. 27  is a plot of calculated and experimental mass median diameter (MMD) versus compound mass in the range of 10 to 310 μg; 
           [0106]      FIG. 28  is a plot of calculated and experimental MMD versus compound mass in the range of 10 to 310 μg; and 
           [0107]      FIG. 29  is a plot of the theoretical size (diameter) of an aerosol as a function of the ratio of the vaporized compound to the volume of the mixing gas. 
       
    
    
     DETAILED DESCRIPTION 
     Definitions 
       [0108]    “Aerodynamic diameter” of a given particle refers to the diameter of a spherical droplet with a density of 1 g/mL (the density of water) that has the same settling velocity as the given particle. 
         [0109]    “Aerosol” refers to a suspension of solid or liquid particles in a gas. 
         [0110]    “Decomposition index” refers to a number derived from an assay described in Example 9. The number is determined by subtracting the percent purity of the generated aerosol from 1. 
         [0111]    “Drug” refers to any chemical compound that is used in the prevention, diagnosis, treatment, or cure of disease, for the relief of pain, or to control or improve any physiological or pathological disorder in humans or animals. Such compounds are oftentimes listed in the Physician&#39;s Desk Reference (Medical Economics Company, Inc. at Montvale, N.J., 56 th  edition, 2002), which is herein incorporated by reference. 
         [0112]    Exemplary drugs include the following: cannabanoid extracts from cannabis, THC, ketorolac, fentanyl, morphine, testosterone, ibuprofen, codeine, nicotine, Vitamin A, Vitamin E acetate, Vitamin E, nitroglycerin, pilocarpine, mescaline, testosterone enanthate, menthol, phencaramkde, methsuximide, eptastigmine, promethazine, procaine, retinol, lidocaine, trimeprazine, isosorbide dinitrate, timolol, methyprylon, etamiphyllin, propoxyphene, salmetrol, vitamin E succinate, methadone, oxprenolol, isoproterenol bitartrate, etaqualone, Vitamin D3, ethambutol, ritodrine, omoconazole, cocaine, lomustine, ketamine, ketoprofen, cilazaprol, propranolol, sufentanil, metaproterenol, prentoxapylline, testosterone proprionate, valproic acid, acebutolol, terbutaline, diazepam, topiramate, pentobarbital, alfentanil HCl, papaverine, nicergoline, fluconazole, zafirlukast, testosterone acetate, droperidol, atenolol, metoclopramide, enalapril, albuterol, ketotifen, isoproterenol, amiodarone HCl, zileuton, midazolam, oxycodone, cilostazol, propofol, nabilone, gabapentin, famotidine, lorezepam, naltrexone, acetaminophen, sumatriptan, bitolterol, nifedipine, Phenobarbital, phentolamine, 13-cis retinoic acid, droprenilamin HCl, amlodipine, caffeine, zopiclone, tramadol HCl, pirbuterol naloxone, meperidine HCl, trimethobenzamide, nalmefene, scopolamine, sildenafil, carbamazepine, procaterol HCl, methysergide, glutathione, olanzapine, zolpidem, levorphanol, buspirone and mixtures thereof. 
         [0113]    Typically, the drug of the composition is of one of the following classes: antibiotics, anticonvulsants, antidepressants, antiemetics, antihistamines, antiparkisonian drugs, antipsychotics, anxiolytics, drugs for erectile dysfunction, drugs for migraine headaches, drugs for the treatment of alcoholism, drugs for the treatment of addiction, muscle relaxants, nonsteroidal anti-inflammatories, opioids, other analgesics, cannabanoids, and stimulants. 
         [0114]    Typically, where the drug is an antibiotic, it is selected from one of the following compounds: cefmetazole; cefazolin; cephalexin; cefoxitin; cephacetrile; cephaloglycin; cephaloridine; cephalosporins, such as cephalosporin C; cephalotin; cephamycins, such as cephamycin A, cephamycin B, and cephamycin C; cepharin; cephradine; ampicillin; amoxicillin; hetacillin; carfecillin; carindacillin; carbenicillin; amylpenicillin; azidocillin; benzylpenicillin; clometocillin; cloxacillin; cyclacillin; methicillin; nafcillin; 2-pentenylpenicillin; penicillins, such as penicillin N, penicillin O, penicillin S, penicillin V; chlorobutin penicillin; dicloxacillin; diphenicillin; heptylpenicillin; and metampicillin. 
         [0115]    Typically, where the drug is an anticonvulsant, it is selected from one of the following compounds: gabapentin, tiagabine, and vigabatrin. 
         [0116]    Typically, where the drug is an antidepressant, it is selected from one of the following compounds: amitriptyline, amoxapine, benmoxine, butriptyline, clomipramine, desipramine, dosulepin, doxepin, imipramine, kitanserin, lofepramine, medifoxamine, mianserin, maprotoline, mirtazapine, nortriptyline, protriptyline, trimipramine, viloxazine, citalopram, cotinine, duloxetine, fluoxetine, fluvoxamine, milnacipran, nisoxetine, paroxetine, reboxetine, sertraline, tianeptine, acetaphenazine, binedaline, brofaromine, cericlamine, clovoxamine, iproniazid, isocarboxazid, moclobemide, phenyhydrazine, phenelzine, selegiline, sibutramine, tranylcypromine, ademetionine, adrafinil, amesergide, amisulpride, amperozide, benactyzine, bupropion, caroxazone, gepirone, idazoxan, metralindole, milnacipran, minaprine, nefazodone, nomifensine, ritanserin, roxindole, S-adenosylmethionine, tofenacin, trazodone, tryptophan, venlafaxine, and zalospirone. 
         [0117]    Typically, where the drug is an antiemetic, it is selected from one of the following compounds: alizapride, azasetron, benzquinamide, bromopride, buclizine, chlorpromazine, cinnarizine, clebopride, cyclizine, diphenhydramine, diphenidol, dolasetron methanesulfonate, dronabinol, droperidol, granisetron, hyoscine, lorazepam, metoclopramide, metopimazine, ondansetron, perphenazine, promethazine, prochlorperazine, scopolamine, triethylperazine, trifluoperazine, triflupromazine, trimethobenzamide, tropisetron, domeridone, and palonosetron. 
         [0118]    Typically, where the drug is an antihistamine, it is selected from one of the following compounds: azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexmedetomidine, diphenhydramine, doxylamine, hydroxyzine, cetrizine, fexofenadine, loratidine, and promethazine. 
         [0119]    Typically, where the drug is an antiparkisonian drug, it is selected one of the following compounds: amantadine, baclofen, biperiden, benztropine, orphenadrine, procyclidine, trihexyphenidyl, levodopa, carbidopa, selegiline, deprenyl, andropinirole, apomorphine, benserazide, bromocriptine, budipine, cabergoline, dihydroergokryptine, eliprodil, eptastigmine, ergoline pramipexole, galanthamine, lazabemide, lisuride, mazindol, memantine, mofegiline, pergolike, pramipexole, propentofylline, rasagiline, remacemide, spheramine, terguride, entacapone, and tolcapone. 
         [0120]    Typically, where the drug is an antipsychotic, it is selected from one of the following compounds: acetophenazine, alizapride, amperozide, benperidol, benzquinamide, bromperidol, buramate, butaperazine, carphenazine, carpipramine, chlorpromazine, chlorprothixene, clocapramine, clomacran, clopenthixol, clospirazine, clothiapine, cyamemazine, droperidol, flupenthixol, fluphenazine, fluspirilene, haloperidol, mesoridazine, metofenazate, molindrone, penfluridol, pericyazine, perphenazine, pimozide, pipamerone, piperacetazine, pipotiazine, prochlorperazine, promazine, remoxipride, sertindole, spiperone, sulpiride, thioridazine, thiothixene, trifluperidol, triflupromazine, trifluoperazine, ziprasidone, zotepine, zuclopenthixol, amisulpride, butaclamol, clozapine, melperone, olanzapine, quetiapine, and risperidone. 
         [0121]    Typically, where the drug is an anxiolytic, it is selected from one of the following compounds: mecloqualone, medetomidine, metomidate, adinazolam, chlordiazepoxide, clobenzepam, flurazepam, lorazepam, loprazolam, midazolam, alpidem, alseroxlon, amphenidone, azacyclonol, bromisovalum, buspirone, calcium N-carboamoylaspartate, captodiamine, capuride, carbcloral, carbromal, chloral betaine, enciprazine, flesinoxan, ipsapiraone, lesopitron, loxapine, methaqualone, methprylon, propanolol, tandospirone, trazadone, zopiclone, and zolpidem. 
         [0122]    Typically, where the drug is a drug for erectile dysfunction, it is selected from one of the following compounds: cialis (IC351), sildenafil, vardenafil, apomorphine, apomorphine diacetate, phentolamine, and yohimbine. 
         [0123]    Typically, where the drug is a drug for migraine headache, it is selected from one of the following compounds: almotriptan, alperopride, codeine, dihydroergotamine, ergotamine, eletriptan, frovatriptan, isometheptene, lidocaine, lisuride, metoclopramide, naratriptan, oxycodone, propoxyphene, rizatriptan, sumatriptan, tolfenamic acid, zolmitriptan, amitriptyline, atenolol, clonidine, cyproheptadine, diltiazem, doxepin, fluoxetine, lisinopril, methysergide, metoprolol, nadolol, nortriptyline, paroxetine, pizotifen, pizotyline, propanolol, protriptyline, sertraline, timolol, and verapamil. 
         [0124]    Typically, where the drug is a drug for the treatment of alcoholism, it is selected from one of the following compounds: naloxone, naltrexone, and disulfuram. 
         [0125]    Typically, where the drug is a drug for the treatment of addiction it is buprenorphine. 
         [0126]    Typically, where the drug is a muscle relaxant, it is selected from one of the following compounds: baclofen, cyclobenzaprine, orphenadrine, quinine, and tizanidine. 
         [0127]    Typically, where the drug is a nonsteroidal anti-inflammatory, it is selected from one of the following compounds: aceclofenac, alminoprofen, amfenac, aminopropylon, amixetrine, benoxaprofen, bromfenac, bufexamac, carprofen, choline, salicylate, cinchophen, cinmetacin, clopriac, clometacin, diclofenac, etodolac, indoprofen, mazipredone, meclofenamate, piroxicam, pirprofen, and tolfenamate. 
         [0128]    Typically, where the drug is an opioid, it is selected from one of the following compounds: alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, carbiphene, cipramadol, clonitazene, codeine, dextromoramide, dextropropoxyphene, diamorphine, dihydrocodeine, diphenoxylate, dipipanone, fentanyl, hydromorphone, L-alpha acetyl methadol, lofentanil, levorphanol, meperidine, methadone, meptazinol, metopon, morphine, nalbuphine, nalorphine, oxycodone, papavereturn, pethidine, pentazocine, phenazocine, remifentanil, sufentanil, and tramadol. 
         [0129]    Typically, where the drug is an other analgesic it is selected from one of the following compounds: apazone, benzpiperylon, benzydramine, caffeine, clonixin, ethoheptazine, flupirtine, nefopam, orphenadrine, propacetamol, and propoxyphene. 
         [0130]    Typically, where the drug is a cannabanoid, it is tetrahydrocannabinol (e.g., delta-8 or delta-9). 
         [0131]    Typically, where the drug is a stimulant, it is selected from one of the following compounds: amphetamine, brucine, caffeine, dexfenfluramine, dextroamphetamine, ephedrine, fenfluramine, mazindol, methyphenidate, pemoline, phentermine, and sibutramine. 
         [0132]    “Drug degradation product” refers to a compound resulting from a chemical modification of a drug. The modification, for example, can be the result of a thermally or photochemically induced reaction. Such reactions include, without limitation, oxidation and hydrolysis. 
         [0133]    “Mass median aerodynamic diameter” or “MMAD” of an aerosol refers to the aerodynamic diameter for which half the particulate mass of the aerosol is contributed by particles with an aerodynamic diameter larger than the MMAD and half by particles with an aerodynamic diameter smaller than the MMAD. 
         [0134]    “Stable aerosol” refers to an aerosol where the MMAD of its constituent particles does not vary by more than 50% over a set period of time. For example, an aerosol with an MMAD of 100 nm is stable over 1 s, if at a time 1 second later it has an MMAD between 50 nm and 150 nm. Preferably, the MMAD does not vary by more than 25% over a set period of time. More preferably, the MMAD does not vary by more than 20%, 15%, 10% or 5% over time. 
       Aerosolization Device 
       [0135]    Example  1  is described in terms of an in vivo dog experiment. The example, however, is easily modified to suit human inhalation primarily through increasing airflow through it. 
         [0136]    Referring to  FIGS. 1-8 , a first example ( 1 ) of an aerosolization device of the present invention will be described. The device  1  as shown in  FIG. 1  is operably connected to flow meter  4  (e.g., a TSI  4100  flow meter). The readings from flow meter  4  are fed to the electronics within chassis  8  shown in  FIG. 2 . Flow meter  4  is shown in  FIG. 1  within a dotted line to indicate housing  10 . Device controller  20  includes Chembook model # N30W laptop computer having actuator switch  22  ( FIG. 3 ) and National Instruments I/O Board (model #SC2345) (not shown) that interfaces with computer  20  to control device  1  and to control the recording of all data collected during the experiments. A software program to carry out these functions was developed using National Instruments&#39; Labview software program. 
         [0137]    Connection between device  1  and the I/O board is accomplished with a cable (e.g., DB25, not shown). A standard power supply (e.g., Condor F15-15-A+ not shown) delivers power to device  1 . Inhalation controller  30  is used to control the rate and volume of inhalation through device  1  into an anesthetized dog through an endotracheal tube  34 . Controller  30  has a programmable breath hold delay, at the end of which, exhaust valve  40  in exhaust line  42  opens and the dog is allowed to exhale. Filter  50  in line  42  measures the amount of exhaust and its composition to monitor any exhaled drug. The source air through inlet line  54 , inlet valve  58 , flow meter  4  and inlet orifice  59  is from a compressed air cylinder (not shown). 
         [0138]    Now referring to  FIGS. 3-5  and  7 , a dose of compound  60  is deposited onto thin, stainless steel foil  64  so that the thickness of compound  60  is less than 10 microns. In most cases, compound  60  is deposited by making a solution of the compound with an organic solvent. This mixture is then applied to the foil substrate with an automated pump system. As shown, the size of the entire foil  64  (e.g., alloy of  302  or  304  with 0.004 in. thickness) is 0.7 by 2.9 inches and the area in which compound  60  is deposited is 0.35 by 1.6 inches. Other foil materials can be used but stainless steel has an advantage over other materials like aluminum in that it has a much lower thermal conductivity value, while not appreciably increasing the thermal mass. A low thermal conductivity is helpful because the heat generated in foil  64  should stay in the area of interest (i.e., the heating/vaporization zone  70 ). Foil  64  should have a constant cross section, because otherwise the electrical currents induced by the heater will not be uniform. Foil  64  is held in frame  68 , made so that the trailing edge of foil  64  has no lip on movable slide  78  and so compound  60 , once mixed with the air, is free in a downstream direction as indicated by arrow  127  of  FIG. 3 . Frame  68  is typically made of a non-conductive material to withstand moderate heat (e.g., 200° C.) and to be non-chemically reactive with the compound (e.g., DELRIN AF®, a copolymer of acetal and TEFLON®). 
         [0139]    Sub-assembly  80 , shown in  FIG. 7 , consists of frame  68  having compound ( 60 ) coated foil  64  mounted therein. Sub-assembly  80  is secured within movable slide  78  by setting each of the downstream, tapered ends of frame  68  to abut against small rods  86  protruding from each downstream end of slide  78 , as shown in  FIG. 7 . Slide  78  is driven by stepper motor  88 , shown in  FIG. 3 , that moves sub-assembly  80  containing compound  60  along the longitudinal axis of example  1 . This, in turn, moves stainless steel foil  64  through an alternating magnetic field. (It is preferable for the magnetic field to be confined within heating/vaporization zone  70 , shown in  FIG. 5 , as in this laboratory example.) Ferrite toroid  90  is used to direct the magnetic field and is placed below foil  64  (e.g., approximately 0.05 inches below). As shown in  FIG. 5 , heated area  70  is approximately 0.15 by 0.4 inches, with the smaller dimension along the direction of travel from left to right (i.e., from the upstream to the downstream ends of device  1 ) and the large dimension across the direction of travel (i.e., the width of device  1 ). 
         [0140]    Foil  64  functions as both a substrate for the drug to be delivered to the subject and the heating element for the vaporization of the drug. Heating element  64  is heated primarily by eddy currents induced by an alternating magnetic field. The alternating magnetic field is produced in ferrite toroid  90  (e.g., from Fair-Rite Company) with slit  94  (e.g., 0.10 in. wide), which was wrapped with coil  98  of copper magnet wire. When an alternating current is passed through coil  98 , an alternating magnetic field is produced in ferrite toroid  90 . A magnetic field fills the gap formed by slit  94  and magnetic field fringe lines  100 , shown in  FIGS. 5 and 6 , extend out from toroid  90 . The magnetic field line fringe lines  100  intersect heating element  64 . When using a ferrite core, the alternating frequency of the field is limited to below 1 MHz. In this device, a frequency between 100 and 300 kHz is typically used. 
         [0141]    The location and geometry of the eddy currents determine where foil  64  will be heated. Since magnetic field fringe lines  100  pass through foil  64  twice, once leaving ferrite toroid  90  and once returning, two rings of current are produced, and in opposite directions. One of the rings is formed around magnetic field lines  100  that leave toroid  90  and the other ring forms around magnetic field lines  100  that return toroid  90 . The rings of current overlap directly over the center of slit  94 . Since they were in opposite directions, they sum together. The greatest heating effect is therefore produced over the center of slit  94 . 
         [0142]    Slide  78  and its contents are housed in airway  102  made up of upper airway section  104  and lower airway section  108  shown in  FIG. 3 . Upper airway section  104  is removable and allows the insertion of movable slide  78 , sub-assembly  80  and foil  64 . Lower airway section  108  is mounted on top of chassis  8  that houses the electronics (not shown), magnetic field generator  110 , stepper motor  88  and position sensors (not shown). Referring again to  FIG. 1 , mounted in upper airway section  104  is upstream passage  120  and inlet orifice  59  that couples upper airway section  104  to flow meter  4 . The readings from the flow meter  4  are fed to the electronics housed in chassis  8 . Additionally, at the downstream end of airway passage  102 , outlet  124  is connected to mouthpiece  126 . During administration of compound  60  to the dog, when joined to the system, air is forced through inlet line  54 , flow meter  4 , airway  102 , and outlet  124  into the dog. 
         [0143]    Additionally, a pyrometer at the end of TC2 line  130  is located within airway  102  and is used to measure the temperature of foil  64 . Because of the specific geometry of the example shown in  FIGS. 1-7 , the temperature reading of foil  64  is taken after heating zone  70 . Calibration of the thermal decay between heating zone  70  and the measurement area is required. Temperature data is collected and used for quality control and verification and not to control any heating parameters. A second temperature sensor is located at the end of TC1 line  132  in outlet  124  and is used to monitor the temperature of the air delivered to the dog. 
         [0144]    In a preferred example of the experimental device, removable block  140 , mounted on upper airway section  104 , restricts a cross-sectional area of airway  102  and provides a specific mixing geometry therein. In this preferred example, airway  140  lowers the roof of upper airway section  104  (e.g., to within 0.04 inch of) with respect to foil  64 . Additionally, block  140  contains baffles (e.g., 31 steel rods 0.04 in. in diameter, not shown). The rods are oriented perpendicular to the foil and extend from the top of upper airway section  104  to within a small distance of the foil (e.g., 0.004 in.). The rods are placed in a staggered pattern and have sharp, squared off ends, which cause turbulence as air passes around them. This turbulence assures complete mixing of vaporized compounds with air passing through the device. 
         [0145]    A second example ( 150 ) of an aerosolization device of the present invention, in which the cross-sectional area is also restricted along the gas/vapor mixing area, will be described in reference to  FIG. 9 . In this example, venturi tube  152  within housing  10  having inlet  154 , outlet  156  includes a throat  158  between inlet  154  and outlet  156 , which is used to restrict the gas flow through venturi tube  152 . Additionally, a controller  160  is designed to control the flow of air passing through a valve  164  based on readings from the thermocouple  168  of the temperature of the air, which can be controlled by heater  166 . 
         [0146]    Block  140  is located directly over heating zone  70  and creates a heating/vaporization/mixing zone. Prior to commencing aerosol generation, slide  78  is in the downstream position. Slide  78 , with its contents, is then drawn upstream into this heating/vaporization/mixing zone  70  as energy is applied to foil  64  through the inductive heater system described in detail below. 
         [0147]    The device of the present invention is optionally equipped with an annunciating device. One of the many functions for the annunciating device is to alert the operator of the device that a compound is not being vaporized or is being improperly vaporized. The annunciating device can also be used to alert the operator that the gas flow rate is outside a desired range.  FIG. 6  is a schematic diagram illustrating a third example of a hand held aerosolization device  180  of the present invention. As shown, device  180  includes many of the components of device  150 , discussed above, and additionally includes an annunciating device  170 . During the use of device  180  in which the patient&#39;s inhalation rate controls the airflow rate, a signal from annunciating device  170  would alert the patient to adjust the inhalation rate to the desired range. In this case, controller  160  would be connected to annunciating device  170  to send the necessary signal that the flow rate was not within the desired range. 
         [0148]    The induction drive circuit  190  shown in  FIG. 8  is used to drive the induction-heating element of device  1 . The purpose of circuit  190  is to produce an alternating current in drive coil  98  wrapped around ferrite core  90 . Circuit  190  consists of two P-channel transistors  200  and two N-channel MOSFET transistors  202  arranged in a bridge configuration. MOSFET transistors  200  and  202  connected to clock pulse generator  219  are turned on and off in pairs by D-type flip-flop  208  through MOSFET transistor drive circuit  210 . D-type flip-flop  208  is wired to cause the Q output of the flip-flop to alternately change state with the rising edge of the clock generation signal. One pair of MOSFET transistors  200  is connected to the Q output on D-type flip-flop  208  and the other pair,  202 , is connected to the Q-not output of flip-flop  208 . When Q is high (5 Volts), a low impedance connection is made between the D.C. power supply (not shown) and the series combination of drive coil  98  and the capacitor through the pair of MOSFET transistors  200  controlled by the Q output. When D-type flip-flop  208  changes state and Q-not is high, the low impedance connection from the power supply to the series combination drive coil  98  and capacitor  220  is reversed. Since flip-flop  208  changes state on the rising edge of the clock generation signal, two flip-flop changes are required for one complete drive cycle of the induction-heating element. The clock generation signal is typically set at twice the resonant frequency of the series combination of drive coil  90  and capacitor  220 . The clock signal frequency can be manually or automatically set. 
         [0149]    A second example ( 150 ) of an aerosolization device of the present invention, in which the cross-sectional area is also restricted along the gas/vapor mixing area, will be described in reference to  FIG. 9 . In this example, venturi tube  152  within housing  10  having inlet  154 , outlet  156  and throat  158  between inlet  154  and outlet  156  is used to restrict the gas flow through venturi tube  152 . Controller  160  is designed to control the flow of air passing through valve  164  based on readings from the thermocouple  168  of the temperature of the air as a result of heater  166 . 
         [0150]    A fourth example ( 300 ) of an aerosolization device of the present invention will be described in reference to  FIGS. 10 and 11 . A gas stream is passed into thin walled tube  302  having a coating ( 310 ) of compound  60  on its inside. The flow rate of the gas stream is controlled by valve  314 . The device of example  300 , as with others, allows for rapid heat-up using a resistive heating system ( 320 ) while controlling the flow direction of vaporized compound. After activating heating system  320  with actuator  330 , current is passed along tube  302  in the heating/vaporization zone  340  as the carrier gas (e.g., air, N 2  and the like) is passed through tube  302  and mixes with the resulting vapor. 
         [0151]      FIG. 12  shows an alternative heating system to resistive heating system  320  used in connection with the fourth example. In this case, inductive heating system  350  consists of a plurality of ferrites  360  for conducting the magnetic flux to vaporize compound  310 . 
         [0152]      FIG. 13  shows a variation on the fourth example in which flow restrictor  370  is mounted within thin-walled tube  302  by means of support  374  within a housing (not shown) to increase the flow of mixing gas across the surface of compound  310 . 
         [0153]    A fifth example  400  of an aerosolization device of the present invention will be described in reference to  FIG. 14 . For this example, compound  60  is placed within expandable container  402  (e.g., a foil pouch) and is heated by resistance heater  406 , which is activated by actuator  410  as shown in  FIG. 14 . The vaporized compound generated is forced into container  420  through outlet passage  440  and mixed with the gas flowing through tube  404 . Additional steps are taken, when necessary, to preclude or retard decomposition of compound  60 . One such step is the removal or reduction of oxygen around 60 during the heat up period. This can be accomplished, for example, by sealing the small container housing in an inert atmosphere. 
         [0154]    A sixth example  500  of an aerosolization device of the present invention will be described in reference to  FIG. 15 . Compound  60  is placed in an inert atmosphere or under a vacuum in container  502  within housing  10  and is heated by resistance heater  504  upon being activated by actuator  508  as shown in  FIG. 15 . Once compound  60  has become vaporized it can then be ejected through outlet passage  510  into the air stream passing through tube  520 . 
         [0155]      FIG. 16  shows a variation of device  500  in which fan  530  recirculates the inert atmosphere over the surface of compound  60 . The inert gas from a compressed gas cylinder (not shown) enters through inlet  540  and one-way valve  550  and exits through outlet passage  510  into tube  502 . 
         [0156]    A seventh example ( 600 ) of an aerosolization device of the present invention will be described in reference to  FIG. 17 . A compound (not shown), such as compound  60  discussed above, is deposited onto a substrate in the form of discrete particles  602  (e.g., aluminum oxide (alumina), silica, coated silica, carbon, graphite, diatomaceous earth, and other packing materials commonly used in gas chromatography). The coated particles are placed within first tube  604 , sandwiched between filters  606  and  608 , and heated by resistance heater  610 , which is activated by actuator  620 . The resulting vapor from tube  604  is combined with the air or other gas passing through second tube  625 . 
         [0157]      FIG. 18  shows a variation of device  600  in which resistance heater  630  heats the air prior to passing through first tube  604  and over discrete particles  602 . 
         [0158]    An eighth example  700  of an aerosolization device of the present invention will be described in reference to  FIG. 19 . Compound  60  is deposited into chamber  710  and is heated by resistance heater  715 , which is activated by actuator  720 . Upon heating, some of compound  60  is vaporized and ejected from chamber  710  by passing an inert gas entering housing  10  through inert gas inlet  725  and valve  728  across the surface of the compound. The mixture of inert gas and vaporized compound passes through passage  730  and is then mixed with a gas passing through tube  735 . 
         [0159]    A ninth example  800  of an aerosolization device of the present invention will be described in reference to  FIG. 20 . Thermally conductive substrate  802  is heated by resistance heater  810  at the upstream end of tube  820 , and the thermal energy is allowed to travel along substrate  802 . This produces, when observed in a particular location, a heat up rate that is determined from the characteristics of the thermally conductive substrate. By varying the material and its cross sectional area, it was possible to control the rate of heat up. The resistive heater is embedded in substrate  802  at one end. However, it could be embedded into both ends, or in a variety of positions along the substrate and still allow the temperature gradient to move along the carrier and/or substrate. 
         [0160]    A tenth example  900  of an aerosolization device of the present invention will be described in reference to  FIGS. 21 and 22 . Air is channeled through a fine mesh metal screen  902  on which drug is deposited. Screen  902  is positioned across airway passage  910  (e.g., constructed from 18 mm glass tubing). The two sides of the screen are electrically connected to charged capacitor  920  through silicon-controlled rectifier (SCR)  922  to make a circuit. The charge of the capacitor is calculated and set at a value such that, when actuator  930  closes SCR  922 , the energy from capacitor  920  is converted to a desired temperature rise in screen  902 . 
       General Considerations 
       [0161]    The device of the present invention utilizes a flow of gas (e.g., air) across the surface of a compound ( 60 ) to sweep away vaporized molecules. This process drives vaporization as opposed to condensation and therefore enables aerosol formation at relatively moderate temperatures. Nicotine (1 mg, by 247° C./745 mm), for example, vaporized in less than 2 s at about 130° C. in a device of the present invention. Similarly, fentanyl (bp&gt;300° C./760 mm) was vaporized around 190° C. in quantities up to 2 mg. 
         [0162]    Purity of an aerosol produced using a device of the present invention is enhanced by limiting the time at which a compound ( 60 ) is exposed to elevated temperatures. This is accomplished by rapidly heating a thin film of the compound to vaporize it. The vapors are then immediately cooled upon entry into a carrier gas stream. 
         [0163]    Typically, compound  60  is subjected to a temperature rise of at least 1,000° C./second. In certain cases, the compound is subjected to a temperature rise of at least 2,000° C./second, 5,000° C./second, 7,500° C. or 10,000° C./second. A rapid temperature rise within the compound is facilitated when it is coated as a thin film (e.g., less than 10μ, 5μ, 4μ, 3μ, 2μ, or 1μ in thickness). The compound is oftentimes coated as a film between 10μ and 10 nm, 5μ and 10 nm, 4μ and 10 nm, 3μ and 10 nm, 2μ and 10 nm, or even 1μ to 10 nm in thickness. 
         [0164]    Rapid temperature rises and thin coatings ensure that compounds are substantially vaporized in a short time. Typically, greater than 0.1 mg, 0.25 mg, 0.5 mg, 0.75 mg or 1 mg of a compound is vaporized in less than 100 milliseconds from the start of heating. Oftentimes, the same amount of compound is vaporized in less than 75 milliseconds, 50 milliseconds, 25 milliseconds, or 10 milliseconds from the start of heating. 
         [0165]    Examples of compounds that have benefited from rapid heating in a device of the present invention include lipophilic substance #87 and fentanyl. Lipophilic substance #87 decomposed by more than 90% when heated at 425° C. for 5 minutes, but only 20% when the temperature was lowered to 350° C. Decomposition of the substance was further lowered to about 12% when the heating time was decreased to 30 seconds and to less than 2% at 10-50 milliseconds. A fentanyl sample decomposed entirely when heated to 200° C. for 30 seconds, and only 15-30% decomposed when heated for 10 milliseconds. Vaporizing fentanyl in device  1  led to less than 0.1% decomposition. 
         [0166]      FIG. 23  is a plot of theoretical data calculated from a mathematical model. See “Aerosol Technology” W. C. Hinds, second edition 1999, Wiley, New York. It shows the time in seconds it takes for the number concentration of an aerosol to aggregate to half of its original value as a function of the particle concentration. For example, a 1.0 mg vaporized dose of a compound with a molecular weight of 200 that is mixed into 1 liter of aire will have approximately 3×10 18  molecules (particles) in the liter. This results in a number concentration of 3×10 15 /cc. Extrapolating from  FIG. 23 , one can see that it takes less than 10 milliseconds for the number of particles to halve in this example. Therefore, to insure uniform mixing of a vaporized compound, the mixing must occur in a very short time.  FIG. 23  also shows that when the number concentration of the mixture reaches approximately 10 9  particles/cc, the particle size is “stable” for the purpose of drug delivery by inhalation. 
         [0167]      FIG. 23  is for an aerosol having a Coagulation Coefficient (K) of 5×10 −16  meters 3 /second. This K value corresponds to a particle size of 200 nm. As the particle size changes, so can its K value. Table 1 below gives the K values for various particle sizes. As K increases, the time required for the aerosol to aggregate from a particular particle size to a larger particle size is reduced. As can be seen from Table 1 and  FIG. 24 , when the particle is in the 10 nm to 100 nm range, the effect of a changing K value tends to accelerate the coagulation process towards 100 nm in size. 
         [0000]    
       
         
               
               
               
             
               
               
               
             
           
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                   
                 Coagulation Coefficient (×e −15   
               
               
                   
                 Particle size (diameter in nm) 
                 meters 3 /second) 
               
               
                   
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 1 
                 3.11 
               
               
                   
                 5 
                 6.93 
               
               
                   
                 10 
                 9.48 
               
               
                   
                 20 
                 11.50 
               
               
                   
                 50 
                 9.92 
               
               
                   
                 100 
                 7.17 
               
               
                   
                 200 
                 5.09 
               
               
                   
                 500 
                 3.76 
               
               
                   
                 1000 
                 3.35 
               
               
                   
                 2000 
                 3.15 
               
               
                   
                 5000 
                 3.04 
               
               
                   
                 10000 
                 3.00 
               
               
                   
                   
               
             
          
         
       
     
         [0168]    In creating an aerosol of a particular particle size, the ratio of mass of vaporized compound to the volume of the mixing gas is the controlling condition. By changing this ratio, the particle size can be manipulated (see  FIG. 29 ). However, not all compounds and not all gases, with the same ratio will result in the same particle size distribution (PSD). Other factors must be known to be able to accurately predict the resultant particle size. A compound&#39;s density, polarity, and temperature are examples of some of these factors. Additionally, whether the compound is hydrophilic or hydrophobic will affect the eventual particle size, because this factor affects an aerosol&#39;s tendency to grow by taking on water from the surrounding environment. 
         [0169]    In order to simplify the approach used to predict the resulting particle size, the following assumptions were made: 
         [0170]    1. The compound is non polar (or has a weak polarity). 
         [0171]    2. The compound is hydrophobic or hydrophilic with a mixing gas that is dry. 
         [0172]    3. The resultant aerosol is at or close to standard temperature and pressure. 
         [0173]    4. The coagulation coefficient is constant over the particle size range and therefore the number concentration that predicts the stability of the particle size is constant. 
         [0174]    Consequently, the following variables are taken into consideration in predicting the resulting particle size: 
         [0175]    1. The amount (in grams) of compound vaporized. 
         [0176]    2. The volume of gas (in cc&#39;s) that the vaporized compound is mixed into. 
         [0177]    3. The “stable” number concentration in number of particles/cc. 
         [0178]    4. The geometric standard deviation (GSD) of the aerosol. 
         [0179]    Where the GSD is 1, all of the particle sizes are the same size and therefore the calculation of particle size becomes a matter of dividing a compound&#39;s mass into the number of particles given by the number concentration and from there calculating the particle size diameter using the density of the compound. The problem becomes different, though, if the GSD is other than 1. As an aerosol changes from a GSD of 1 to a GSD of 1.35, the mass median diameter (MMD) will increase. MMD is the point of equilibrium where an equal mass of material exists in smaller diameter particles as exists in larger diameter particles. Since total mass is not changing as the GSD changes, and since there are large and small particles, the MMD must become larger as the GSD increases because the mass of a particle goes up as the cube of its diameter. Therefore larger particles, in effect, carry more weight and the MMD becomes larger to “balance” out the masses. 
         [0180]    To determine the effect of a changing GSD, one can start with the formula for the mass per unit volume of an aerosol given a known MMD, GSD, density, and number concentration. The formula is from Finlay&#39;s “The Mechanics of Inhaled Pharmaceutical Aerosols” (2001, Academic press). Formula 2.39 states that the mass per unit volume of an aerosol is: 
         [0000]        M =(ρ Nπ/ 6)( MMD ) 3 exp[−9/2(ln σ g ) 2 ]
 
         [0181]    Where: 
         [0182]    ρ=density in gm/cc 
         [0183]    N=Number concentration in particles/cc 
         [0184]    MMD=mass median diameter (in cm) 
         [0185]    σ g =the GSD 
         [0186]    M=the mass per unit volume of the aerosol in gms/cc 
         [0187]    If the change in the MMD is considered as an aerosol changes from one GSD to another, while the density, number concentration, and the mass remain unchanged the following equality can be set up: 
         [0000]        pNπ/ 6( MMD   1 ) 3 exp[−9/2(ln σ g1 ) 2   ]=pNπ/ 6( MMD   2 ) 3 exp[−9/2(ln σ g2 ) 2 ]
 
         [0000]      simplifying: 
         [0000]      (MMD 1 ) 3 exp[−9/2(ln σ g1 ) 2 ]=(MMD 2 ) 3 exp[−9/2(ln σ g2 ) 2 ]
 
         [0000]      Or 
         [0000]      (MMD 1 ) 3 /(MMD 2 ) 3 =exp[−9/2(ln σ g2 ) 2 ]/exp[−9/2(ln σ g1 ) 2 ]
 
         [0000]    If one sets the GSD of case 1 to 1.0 then: 
         [0000]      exp[−9/2(ln σ g1 ) 2 =1
 
         [0000]      And therefore: 
         [0000]      ( MMD   1   /MMD   2 ) 3 =exp[−9/2 (ln σ g2 ) 2 ]
 
         [0000]      Or: 
         [0000]        MMD   1   /MMD   2 =exp[−3/2(ln σ g2 ) 2 ]
 
         [0188]    It is advantageous to calculate the change in the MMD as the GSD changes. Solving for MMD 2  as a function of MMD 1  and the new GSD 2  yields: 
         [0000]        MMD   2   =MMD   1 /exp[−3/2(ln σ g2 ) 2   ] for a σ   g1 =1
 
         [0189]    To calculate MMD 1, divide the compound&#39;s mass into the number of particles and then, calculate its diameter using the density of the compound. 
         [0000]        MMD   1 =(6 C/pNV ) 1/3  for an aerosol with a GSD of 1 
         [0190]    Where:
       C=the mass of the compound in gm&#39;s   ρ=Density in gm/cc (as before)   N=Number concentration in particles/cc (as before)   V=volume of the mixing gas in cc       
 
         [0195]    Insertion of MMD 1 into the above equation leads to: 
         [0000]        MMD   2 =(6 C/pNV π) 1/3  [exp[−3/2(ln σ g2 ) 2 ], measured in centimeters.
 
         [0196]    A resultant MMD can be calculated from the number concentration, the mass of the compound, the compound density, the volume of the mixing gas, and the GSD of the aerosol. 
         [0197]    The required vaporization rate depends on the particle size one wishes to create. If the particle size is in the 10 nm to 100 nm range, then the compound, once vaporized, must be mixed, in most cases, into the largest possible volume of air. This volume of air is determined from lung physiology and can be assumed to have a reasonable upper limit of 2 liters. If the volume of air is limited to below 2 liters (e.g., 500 cc), too large a particle will result unless the dose is exceedingly small (e.g., less than 50 μg). 
         [0198]    In the 10 nm to 100 nm range, doses of 1-2 mg are possible. If this dose is mixed into 2 liters of air, which will be inhaled in 1-2 seconds, the required, desired vaporization rate is in the range of about 0.5 to about 2 mg/second. 
         [0199]    The first example of the present invention is shown in  FIG. 1  and is the basic device through which the principles cited above have been demonstrated in the laboratory. This device is described in detail in the EXAMPLES. 
         [0200]    In the second example of the present invention shown in  FIG. 9 , the use of a reduced airway cross section increases the speed of the air across the compound&#39;s surface to about 10 meters/second. If complete mixing is to happen within 1 millisecond, then the distance the gas and vaporized mixture must travel to achieve complete mixing must be no longer than 10 millimeters. However, it is more desirable for complete mixing to happen before the compound has aggregated to a larger size, so a desirable mixing distance is typically about 1 millimeter or less. 
         [0201]    In the fourth example of the present invention shown in  FIGS. 10-13 , an aerosol having particles with an MMAD in the 10 nm to 100 nm range is generated by allowing air to sweep over a thin film of the compound during the heating process. This allows the compound to become vaporized at a lower temperature due to the lowering of the partial pressure of the compound near the surface of the film. 
         [0202]    The fifth example shown in  FIG. 14 , the sixth example shown in  FIGS. 15 and 16 , and the eighth example shown in  FIG. 19  overcome a problem with certain compounds that react rapidly with oxygen at elevated temperatures. To solve this problem, the compound is heated in an expandable container (fourth example), a small container housing under a vacuum or containing a small amount, e.g., about 1 to about 10 ml, of an inert gas (fifth example). Once a compound is vaporized and mixed with an inert gas while the gaseous mixture is maintained at a temperature sufficient to keep the compound in its vaporized state, the gaseous mixture is then injected into an air stream. The volume of inert gas can also be re-circulated over the surface of the heated compound to aid in its vaporization as shown in  FIG. 16 . In the seventh example, the compound is introduced into the gas as a pure vapor. This involves vaporizing the compound in an oven or other container and then injecting the vapor into an air or other gas stream through one or more mixing nozzles. 
         [0203]    In the sixth example shown in  FIGS. 17-18 , gas is passed through a first tube and over discrete substrate particles, having a large surface area to mass ratio, and coated with the compound. The particles are heated as shown in  FIG. 17  to vaporize the compound, or the gas is heated and the heated gas vaporizes the compound as shown in  FIG. 18 . The gaseous mixture from the first tube is combined with the gas passing through second tube to rapidly cool the mixture before administering it to a patient. 
         [0204]    The eighth example shown in  FIG. 20  is a thermal gradient device that is similar to device  1  used in the laboratory experiments. This example also has a moving heating zone without any moving parts, accomplished by establishing a heat gradient that transverses from one end of the device to the other over time. As the heating zone moves, exposed portions of the compound are sequentially heated and vaporized. In this manner the vaporized compound can be introduced into a gas stream over time. 
         [0205]    The ninth example shown in  FIGS. 21-22  is the screen device and is preferred for generating a aerosols containing particles with an MMAD greater than 100 nm. In this example, air is channeled through a fine mesh screen upon which the drug to be administered to the patient has been deposited. 
         [0206]    The examples above can create aerosols without significant drug decomposition. This is accomplished while maintaining a required vaporization rate for particle size control by employing a short duration heating cycle. An airflow over the surface of the compound is established such that when the compound is heated and reaches the temperature where vaporization is first possible, the resulting compound vapors will immediately cool in the air. In the preferred examples, this is accomplished by extending the increased velocity and mixing region over an area that is larger than the heating zone region. As a result, precise control of temperature is not necessary since the compound vaporizes the instant its vaporization temperature is reached. Additionally because mixing is also present at the point of vaporization, cooling is accomplished quickly upon vaporization. 
         [0207]    Application of the present invention to human inhalation drug delivery must accommodate constraints of the human body and breathing physiology. Many studies of particle deposition in the lung have been conducted in the fields of public health, environmental toxicology and radiation safety. Most of the models and the in vivo data collected from those studies, relate to the exposure of people to aerosols homogeneously distributed in the air that they breathe, where the subject does nothing actively to minimize or maximize particle deposition in the lung. The International Commission On Radiological Protection (ICRP) models are examples of this. (See James A C, Stahlhofen W, Rudolph G, Egan M J, Nixon W, Gehr P, Briant J K,  The respiratory tract deposition model proposed by the ICRP Task Group, Radiation Protection Dosimetry,  1991; vol. 38: pgs. 157-168). 
         [0208]    However, in the field of aerosol drug delivery, a patient is directed to breathe in a way that maximizes deposition of the drug in the lung. This kind of breathing usually involves a full exhalation, followed by a deep inhalation sometimes at a prescribed inhalation flow rate range, e.g., about 10 to about 150 liters/minute, followed by a breath hold of several seconds. In addition, ideally, the aerosol is not uniformly distributed in the air being inhaled, but is loaded into the early part of the breath as a bolus of aerosol, followed by a volume of clean air so that the aerosol is drawn into the alveoli and flushed out of the conductive airways, bronchi and trachea by the volume of clean air that follows. A typical deep adult human breath has a volume of about 2 to 5 liters. In order to ensure consistent delivery in the whole population of adult patients, delivery of the drug bolus should be completed in the first 1-1½ liters or so of inhaled air. 
         [0209]    As a result of the constraints of human inhalation drug delivery, a compound should be vaporized in a minimum amount of time, preferably no greater than 1 to 2 seconds. As discussed earlier, it is also advantageous, to keep the temperature of vaporization at a minimum. In order for a compound to be vaporized in 2 seconds or less and for the temperature to be kept at a minimum, rapid air movement, in the range of about 10 to about 120 liters/minute, should flow across the surface of the compound. 
         [0210]    The following parameters are optimal in using a device of the present invention, due to human lung physiology, the physics of particle growth, and the physical chemistry of the desirable compounds: 
         [0211]    (1) The compound should to be vaporized over approximately 1 to 2 seconds for creation of particles in the ultra fine range. 
         [0212]    (2) The compound should to be raised to the vaporization temperature as rapidly as possible. 
         [0213]    (3) The compound, once vaporized, should be cooled as quickly as possible. 
         [0214]    (4) The compound should be raised to the maximum temperature for a minimum duration of time to minimize decomposition. 
         [0215]    (5) The air or other gas should be moved rapidly across the surface of the compound to achieve the maximum rate of vaporization. 
         [0216]    (6) The heating of the air or other gas should be kept to a minimum, i.e., an increase of temperature of no greater than about 15° C. above ambient. 
         [0217]    (7) The compound should be mixed into the air or other gas at a consistent rate to have a consistent and repeatable particle size. 
         [0218]    (8) As the gas speed increases across the compound being vaporized, the cross sectional area through the device should decrease. Furthermore, as the surface area of the compound increases the heating of the gas increases. 
         [0219]    The parameters of the design for one of the examples shown in  FIGS. 2-5 ,  7  and  8  are the result of meeting and balancing the competing requirements listed above. One especially important requirement for an aerosol containing particles with an MMAD between 10 nm and 100 nm is that a compound, while needing to be vaporized within at least a 1-second period, also needs to have each portion of the compound exposed to a heat-up period that is as brief as possible. In this example, the compound is deposited onto a foil substrate and an alternating magnetic field is swept along a foil substrate heating the substrate such that the compound is vaporized sequentially over no more than about a one second period of time. Because of the sweeping action of the magnetic field, each segment of the compound has a heat-up time that is much less than one second. 
         [0220]    In the example noted directly above, the compound is laid down on a thin metallic foil. In one of the examples set forth below, stainless steel (alloy of  302 ,  304 , or  316 ) was used in which the surface was treated to produce a rough texture. Other foil materials can be used, but it is important that the surface and texture of the material is such that it is “wetted” by the compound when the compound is in its liquid phase, otherwise it is possible for the liquid compound to “ball” up which would defeat the design of the device and significantly change the volatilizing parameters. If the liquid compound “balls” up, the compound can be blown into and picked up by the airflow without ever vaporizing. This leads to delivery of a particle size that is uncontrolled and undesirable. 
         [0221]    Stainless steel has advantages over materials like aluminum because it has a lower thermal conductivity value, without an appreciable increase in thermal mass. Low thermal conductivity is helpful because heat generated by the process needs to remain in the immediate area of interest. 
       EXAMPLES 
       [0222]    The following examples further illustrate the method and various examples of the present invention. These examples are for illustrative purposes and are not meant to limit the scope of the claims in any way. 
       Example 1 
     In Vivo Results Using Example 1 
       [0223]    In this example, example 1, was designed to deliver an experimental dose of fentanyl between 20 μg and 500 μg, in a range of ultra fine particle sizes, in about 800 cc of air to a 10 kg dog. The lung volume of each dog under experimentation was approximately 600-700 cc and the device was designed to deliver the compound to the lung in the first half of the inhalation. Because of the value of these parameters, device  1  in this experiment can be considered a ¼ scale device for administering a dose to a human. It is believed that scaling the device to work for human subjects involves mainly increasing the airflow through the device. The time frame of the introduction of the compound into the heating/vaporization/mixing zone was set such that the compound vaporized into a volume of air that was suitable for both the volume required by dog lung anatomy (600-700 cc) and the volume needed to control the ratio of the compound to the air. 
         [0224]    The following was the sequence of events that took place during each operation: 
         [0225]    1. At the beginning of the run, the operator triggered inhalation controller  30  to start monitoring data from pressure transducer  240  and input flow meter  4 . 
         [0226]    2. Controller  30  signaled controller  20  to start example 1 and to begin collecting data from the two temperature sensors and flow meter  4 . 
         [0227]    3. After a pre-programmed delay, example 1 initiated the generation of the aerosol. (Note: there was a delay of about 0.4 seconds between the start of the controller  30  and the start of aerosol generation.) 
         [0228]    4. After an independent preprogrammed delay (from original trigger signal), controller  30  opened input valve  58  to start forced inhalation to a dog under experimentation. 
         [0229]    5. Example 1 completed the aerosol generation during the inhalation. 
         [0230]    6. Controller  30  monitored flow meter  4  and pressure transducer  240  throughout the inhalation and closed off flow at input valve  58  when a pre-specified volume or pressure was met. (Note: the pre-specified pressure is a safety feature to prevent injury to the subject animal. Termination of the breath at the pre-specified volume is the desirable occurrence of the experiment.) 
         [0231]    7. After a breath hold delay (5 seconds), exhaust valve  40  was opened and the dog was allowed to exhale. 
         [0232]    8. Exhaled aerosol was trapped on exhaust filter  40  for later analysis. Controller  30  recorded values for the following: volume dispensed, terminal pressure, duration of air pulse, and average flow rate. Controller  20  continuously recorded at millisecond resolution, input flow rate, exhaust flow rate, foil temperature, mouthpiece temperature, slide position, heater on/off time, and other internal diagnostic electrical parameters. 
         [0233]    Three weight-matched female beagle dogs received fentanyl at a 100 μg intravenous bolus dose. The same dogs received fentanyl UF for Inhalation (100 μg aerosolized and administered as two successive activations of device  1 , containing approximately 50 ng fentanyl base) at a particle size of  80  nm (MMAD). The aerosol was administered to anesthetized dogs via the system schematically represented in  FIG. 1 , with a target delivered volume of 600-700 ml air, followed by a 5 second breath hold. After dosing, plasma samples for pharmacokinetic analysis were obtained at various time points from 2 min to 24 hr. Fentanyl remaining in device  1  was recovered and measured. Fentanyl concentrations were measured by using a validated GC method, with a limit of detection of 0.2 ng/ml. 
         [0234]    Plasma pharmacokinetics from this example were compared to intravenous (IV) fentanyl (100 ng) in the same dogs. Inhalation of fentanyl resulted in rapid absorption (C max , maximum concentration in plasma, 11.6 ng/ml and T max , maximum time, 2 min.) and high bioavailability (84%). The time course of inhaled fentanyl was nearly identical to that of IV fentanyl. Thus, fentanyl UF for inhalation had an exposure profile that was similar to that of an IV injection. 
         [0235]    Standard non-compartmental pharmacokinetic methods were used to calculate pharmacokinetic parameters for each animal. The maximum concentration in plasma (C max ) and the maximum time it occurred (T max ) were determined by examination of the data. The area under the plasma concentration vs. time curve (AUC) was determined. The bioavailability (F) of inhaled fentanyl was determined as: 
         [0000]        F =( DIV/DINHAL )*( AUCINHAL/AUCIV ) 
         [0236]    where D was the dose and AUC was the AUC determined to the last measurable time point. 
         [0237]      FIG. 26  plots the data obtained on the blood levels, by dog, for both the IV doses and the inhalation doses using device  1  as described above under Example 1. 
         [0238]    The fentanyl aerosol was rapidly absorbed, with the same T max  (2 min, the earliest time point) observed for both routes of administration. The maximum plasma concentration of fentanyl aerosol (11.6±1.9 ng/ml) was nearly two-thirds that of IV fentanyl (17.6±3.6 ng/ml). Plasma concentrations fell below the assay limit of quantitation by 6-8 hr after IV administration and by 3-4 hr after aerosol inhalation. Bioavailability calculations were based on the AUC&#39;s observed to the last measurable time point for the inhalation administration. Bioavailability for the inhalation study was 84% based on the nominal (uncorrected) fentanyl dose. 
         [0239]    The mean plasma elimination half-life was similar after IV (75.4 min) and inhalation dose. Distribution phase half-lives (3-4 min) were also similar after both routes of administration. The inter-animal variability of pharmacokinetic parameters after the inhalation dose was low, with relative standard deviations (RSD&lt;25%) lower than those observed for IV administration. 
       Example 2 
     In Vitro Results Using Example 1 
       [0240]    Table 2 below summarizes the data collected from use of example 1 for in vitro testing of fentanyl. Particle size was measured with a Moudi cascade impactor. 
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
               
                 Compound Mass (ug) 
                 Mixing air volume (cc) 
                 MMAD (nm) 
                 GSD 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 20 
                 400 
                 71 
                 1.9 
               
               
                 25 
                 400 
                 72-78 
                 1.7-1.8 
               
               
                 50 
                 400 
                 77-88 
                  1.7-185 
               
               
                 100 
                 400 
                 100-105 
                 1.4-1.8 
               
               
                 200 
                 400 
                 103-123 
                 1.6-1.9 
               
               
                 300 
                 400 
                 140-160 
                 1.8-2.1 
               
               
                   
               
             
          
         
       
     
       Example 3 
     Use of Example 1 to Make Fine Aerosol Particles 
       [0241]    In this example, example 1 was slightly modified and the flow rate changed, as discussed below, to make a fine aerosol in the 1 to 3 micron particle size range. 
         [0242]    Airway section  140  was removed and the air channel heating/vaporization zone  70  was changed. An airway insert (not shown) had a “roof” that was 0.25 inches above the foil. There were no mixing rods as rapid mixing was not desirable in this example. Because of these two device changes, there was much less mixing with the air, thus the vapor/aerosol cloud was mixed with less air and produced a larger particle size aerosol. The airflow rate was reduced 1 liter/minute in this example. Again, this allowed the vapor to be mixed with much less air, resulting in the larger particle size aerosol. 
         [0243]    Some operational problems with high compound loading on foil  64  in example 1 were encountered. The compound tested, dioctyl phthalate (DOP), was an oil and during the aerosolization process, a substantial quantity was blown downwind and not aerosolized. Three additional design alternatives were made to address this issue, involving changes to the substrate surface that the compound was deposited on. In the three alternatives, the substrate was made to “hold” the compound through the use of texture. They were: a) texturing the foil; b) adding a stainless steel screen on top of the foil; and, c) replacing the foil with a fine stainless steel screen. 
         [0244]    The results from this example are set forth below in Table 3 below: 
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                 Substrate Type 
                 MMAD, microns 
                 GSD 
                 Emitted Dose, ug 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Textured foil 
                 1.49 microns 
                 1.9 
                 97 
               
               
                 Textured foil 
                 2.70 microns 
                 1.95 
                 824 
               
               
                 Fine screen alone 
                 1.59 microns 
                 1.8 
                 441 
               
               
                 Fine screen alone 
                 1.66 microns 
                 1.8 
                 530 
               
               
                 Screen on Foil 
                 2.42 microns 
                 2.2 
                 482 
               
               
                   
               
             
          
         
       
     
         [0245]    As shown above, a fine particle size can be made with device  1  merely by changing the ratio of the compound to the mixing air. 
       Example 4 
     In Vitro Results Using Example  700   
       [0246]    A tank was partially filled with DOP and placed inside an oven (not shown) having an inlet and an outlet. DOP was used as the test compound. The tank was purged with helium prior to heating the tank and its contents to a temperature of 350° C. Helium was pumped through the tank and used to carry the DOP vapor out of the outlet. The gaseous mixture of helium and vaporized compound  60  was introduced into different size mixing tubes through a nozzle. Each of the tubes had air moving through them at 14 liters/minute. The nozzle was perpendicular to the flow direction. After this gaseous mixture was mixed with the air, the resulting aerosol was introduced into a parallel flow diffusion battery for particle size analysis. Results are set forth in Table 4 below. 
         [0000]                            TABLE 4               Mixing tube size (ID)   MMAD   GSD                   4.8 mm    65 nm   1.3        14 mm   516 nm   3.3                    
As can be seen above, as the tube diameter became larger so did the particle size. Additionally, as the diameter became larger, the GSD also became larger. As the tube becomes larger, it is believed that the vaporized gas is introduced into a smaller segment of the mixing gas because the gas is being introduced as a point source leading to uneven mixing, which results in a large GSD.
 
       Example 5 
     In Vitro Results Using Example  800   
       [0247]    To demonstrate effectiveness of example  800 , a 4-inch long piece of aluminum was fitted with a 150-watt cartridge heater at one end. The heater was powered with a variac AC power transformer. The thickness of the aluminum was designed to ensure that heat would transverse from one end of the aluminum to the other in approximately 30 seconds. 
         [0248]    On the topside of the aluminum, an indentation was machined to hold the compound and to hold one of two top covers. The indentation for the compound was approximately 3.5 inches long and 0.4 inches wide. The indentation was 0.025 inches deep, and was filled with 1 mg of DOP. 
         [0249]    The first top consisted of a sheet of flat glass placed 0.04 inches above the heated surface, creating an airway. At the exit end an outlet was fitted allowing the air to be drawn into an analytical measurement device. Air was made to flow through the airway at a rate of 15 liters/minute. 
         [0250]    In the second configuration, the top was replaced with a half cylinder made of glass. This increased the cross sectional area of the airway by an order of magnitude. 
         [0251]    Particle size was measured with both configurations and shown to be affected by the cross sectional area of the airway. 
         [0252]    Results from the thermal gradient test are set forth in Table 5 below: 
         [0000]    
       
         
               
               
               
               
             
           
               
                   
                 TABLE 5 
               
               
                   
                   
               
               
                   
                 Cover size and 
                   
                   
               
               
                   
                 cross-section 
                 MMAD 
                 GSD 
               
               
                   
                   
               
             
             
               
                   
                 Small 
                  92 nm 
                 1.4 
               
               
                   
                 Big 
                 650 nm 
                 unknown 
               
               
                   
                   
               
             
          
         
       
     
         [0253]    As shown above, the results confirm that as the cross section becomes larger, so does the particle size. 
       Example 6 
     In Vitro Results Using Example  900   
       [0254]    In this example for producing aerosols, airway passage  910  was constructed from 18 mm diameter glass tubing. However, the passage can be made in any shape with a comparable cross-sectional area and out of any suitable material. The screen size, mesh, and the amount of compound were chosen in this example so that a gas could pass through the screen without interference once the compound had been deposited on it. 
         [0255]    Because the internal resistance of the screen was low, i.e., between 0.01 and 0.2 ohms, the discharge rate (the RC time constant) of the capacitor was rapid, and on the order of a few milliseconds, i.e. less than 20 milliseconds, preferably in the range of about 2 to about 10 milliseconds. Upon discharge of capacitor  902  and the subsequent heating of screen  902 , the deposited compound was rapidly vaporized. Because air moved through screen  902 , the vaporized compound rapidly mixed with air and cooled. 
         [0256]    The compound was deposited onto the fine stainless steel screen, e.g., 200 mesh, made from 316 stainless steel, having measurements of 2.54 cm.×2.54 cm. The current from the capacitor was passed between one edge and another. It was not necessary to heat the screen to temperatures comparable to the thin foil in Example 1, because the compound vaporized at a lower temperature due to the rapid air movement. Rapid air movement allowed the compound to vaporize at a lower vapor pressure, since airflow constantly removed compound vapors from the surface as soon as they were formed. Thus, the compound vaporized at a lower temperature without decomposition. 
         [0257]    Deposition of the compound onto the screen was accomplished by mixing the compound with an organic solvent until the compound dissolved. The resulting solution was then applied to the fine stainless steel screen  902  and the solvent was allowed to evaporate. The screen was then inserted into holder  940  that electrically connected two sides of screen  902  to the power circuit described above. 
         [0258]    A 10,000 mF capacitor was discharged while the gas was passing through screen  902 . The rapid heat up of the screen resulted in a rapid vaporization of the compound into the gas. Thus the resulting vaporized compound was mixed into a small volume of the gas. Because the ratio of the mass of the compound to the volume of the mixing gas was large, a fine (1-3 micron diameter) particle aerosol was made. 
       Example 7 
     Flash Device for Forming Aerosols 
       [0259]    A high-power flashcube (GE or Sylvania), which can produce 300-400 J of energy, was inserted into an anodized aluminum tube. The flashcube/tube assembly was dipped into an organic solution containing a drug and quickly removed. Evaporation of residual solvent from the assembly was performed by placing it into a vacuum chamber for 30 min. This left a film of drug coated on the exterior surface of the aluminum tube. The flashbulb assembly was electrically connected to two 1.5 V batteries and a switch using copper wires and then enclosed in a sealed, glass vial. Ignition of the flashbulb was performed by momentarily turning on the switch between the flashbulb and batteries. After ignition, the vial was kept closed for 30 minutes such that particles of volatilized drug coagulated and condensed on the inside surface of the vial. Analysis of the aerosol involved rinsing the vial with 5 mL of acetonitrile and injecting a sample of the organic solution into an HPLC. 
         [0260]    Measurement with a fast thermocouple indicated that the aluminum tube heated up to 600° C. in 50 milliseconds. This translates into a heating rate of 12,000°/s. 
         [0261]    One of ordinary skill in the art would understand that the experimental device detailed above could be transformed into an inhalation delivery device by excluding the sealed vial and including a housing to contain the assembly and electrical components. The housing would contain an air inlet and a mouthpiece such that, when drug volatilization occurred, an inhaled breath would carry the formed aerosol into the lungs of a subject. 
       Example 8 
     Relationship Between Film Thickness and Aerosol Purity 
       [0262]    Sildenafil was dissolved in a minimal amount of dichloromethane. The resulting solution was coated onto a piece of pure aluminum foil, and the residual solvent was allowed to evaporate. The coated foil was placed on an aluminum block that had been preheated to 275° using a hot plate. A pyrex beaker was synchronously placed over the foil, and the coated material was allowed to vaporize for 1 min. The beaker was removed, and the adsorbed aerosol was extracted using dichloromethane. HPLC analysis (250 nm) of an aliquot of the extract provided purity data for the aerosol. Using this procedure the following data were obtained: 3.4μ thickness, 84.8% purity; 3.3μ thickness 80.1% purity; 1.6μ thickness, 89.8% purity; 0.8μ thickness, 93.8% purity; 0.78μ thickness, 91.6% purity; 0.36μ thickness, 98.0% purity; 0.34μ thickness, 98.6% purity; 0.29μ thickness, 97.6% purity; and, 0.1μ, 100% purity. 
       Example 9 
     General Procedure for Screening Drugs to Determine Aerosolization Preferability 
       [0263]    Drug (1 mg) is dissolved or suspended in a minimal amount of solvent (e.g., dichloromethane or methanol). The solution or suspension is pipetted onto the middle portion of a 3 cm by 3 cm piece of aluminum foil. The coated foil is wrapped around the end of a 1½ cm diameter vial and secured with parafilm. A hot plate is preheated to approximately 300° C., and the vial is placed on it foil side down. The vial is left on the hotplate for 10 s after volatilization or decomposition has begun. After removal from the hotplate, the vial is allowed to cool to room temperature. The foil is removed, and the vial is extracted with dichloromethane followed by saturated aqueous NaHCO 3 . The organic and aqueous extracts are shaken together, separated, and the organic extract is dried over Na 2 SO 4 . An aliquot of the organic solution is removed and injected into a reverse-phase HPLC with detection by absorption of 225 nm light. A drug is preferred for aerosolization where the purity of the drug isolated by this method is greater than 85%. Such a drug has a decomposition index less than 0.15. The decomposition index is arrived at by subtracting the percent purity (i.e., 0.85) from 1. 
         [0264]    One of ordinary skill in the art can combine the foregoing embodiments or make various other embodiments and aspects of the method and device of the present invention to adapt them to specific usages and conditions. As such, these changes and modifications are properly, equitably, and intended to be, within the full range of equivalents of the following claims.