Abstract:
The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a divisional of application Ser. No. 11/821,327, entitled “Biocompatible Electroplated Interconnection Bonding Method and Electronics Package Suitable for Implantation”, filed Jun. 21, 2007. 
    
    
     FEDERALLY SPONSORED RESEARCH 
     This invention was made with government support under grant No. R24EY12893-01, awarded by the National Institutes of Health. The government has certain rights in the invention. 
    
    
     FIELD OF THE INVENTION 
     This invention relates to an electrode array or flexible circuit, electronics package and a method of bonding a flexible circuit or electrode array to an integrated circuit or electronics package. 
     BACKGROUND OF THE INVENTION 
     Arrays of electrodes for neural stimulation are commonly used for a variety of purposes. Some examples include U.S. Pat. No. 3,699,970 to Brindley, which describes an array of cortical electrodes for visual stimulation. Each electrode is attached to a separate inductive coil for signal and power. U.S. Pat. No. 4,573,481 to Bullara describes a helical electrode to be wrapped around an individual nerve fiber. U.S. Pat. No. 4,837,049 to Byers describes spike electrodes for neural stimulation. Each spike electrode pierces neural tissue for better electrical contact. U.S. Pat. No. 5,215,088 to Norman describes an array of spike electrodes for cortical stimulation. U.S. Pat. No. 5,109,844 to de Juan describes a flat electrode array placed against the retina for visual stimulation. U.S. Pat. No. 5,935,155 to Humayun describes a retinal prosthesis for use with a flat retinal array. 
     Packaging of a biomedical device intended for implantation in the eye, and more specifically for physical contact with the retina, presents a unique interconnection challenge. Biocompatible bonding method and electronics package suitable for implantation are described in U.S. Pat. Nos. 7,211,103 and 7,142,909 as well as in U.S. Patent applications Nos. 2007/0021787 and 2007/0005112. The consistency of the retina is comparable to that of wet tissue paper and the biological media inside the eye is a corrosive saline liquid environment. 
     Thus, the device to be placed against the retina, in addition to being comprised of biocompatible, electrochemically stable materials, must appropriately conform to the curvature of the eye, being sufficiently flexible and gentle in contact with the retina to avoid tissue damage, as discussed in Andreas Schneider, Thomas Stieglitz, Werner Haberer, Hansjörg Beutel, and J.-Uwe Meyer, “Flexible Interconnects for Biomedical Microsystems Assembly, IMAPS Conference, Jan. 31, 2001. It is also desirable that this device, an electrode array, provides a maximum density of stimulation electrodes. A commonly accepted design for an electrode array is a very thin, flexible conductor cable. It is possible to fabricate a suitable electrode array using discrete wires, but with this approach, a high number of stimulation electrodes cannot be achieved without sacrificing cable flexibility (to a maximum of about 16 electrodes). 
     A lithographically fabricated thin film flex circuit electrode array overcomes such limitations. A thin film flex circuit electrode array can be made as thin as 10 um (0.0004 inches) while accommodating about 60 electrodes in a single circuit routing layer. The flex circuit electrode array is essentially a passive conductor ribbon that is an array of electrode pads, on one end, that contact the retina and on the other end an array of bond pads that must individually mate electrically and mechanically to the electrical contacts of a hermetically sealed electronics package. These contacts may emerge on the outside of the hermetic package as an array of protruding pins or as vias flush to a package surface. A suitable interconnection method must not only serve as the interface between the two components, but must also provide electrical insulation between neighboring pathways and mechanical fastening between the two components. 
     Many methods exist in the electronics industry for attaching an integrated circuit to a flexible circuit. Commonly used methods include wire-bonding, anisotropic-conductive films, and “flip-chip” bumping. However, none of these methods results in a biocompatible connection. Common materials used in these connections are tin-lead solder, indium and gold. Each of these materials has limitations on its use as an implant. Lead is a known neurotoxin. Indium corrodes when placed in a saline environment. 
     In many implantable devices, the package contacts are feedthrough pins to which discrete wires are welded and subsequently encapsulated with polymer materials. Such is the case in heart pacemaker and cochlear implant devices. Flexible circuits are not commonly used, if at all, as external components of proven implant designs. The inventor is unaware of prior art describing the welding of contacts to flex circuits. 
     Attachment by gold ball bumping has been demonstrated by the Fraunhofer group (see Hansjoerg Beutel, Thomas Stieglitz, Joerg Uwe Meyer, “Versatile ‘Microflex’-Based Interconnection Technique,” Proc. SPIE Conf on Smart Electronics and MEMS, San Diego, Calif., March 1998, vol 3328, pp 174-82) to rivet a flex circuit onto an integrated circuit. A robust bond can be achieved in this way. However, encapsulation proves difficult to effectively implement with this method. Because the gap between the chip and the flex circuit is not uniform, under fill with epoxy is not practical. Thus, electrical insulation cannot be achieved with conventional under fill technology. 
     Widespread use of flexible circuits can be found in high volume consumer electronics and automotive applications, such as stereos. These applications are not constrained by a biological environment. Component assembly onto flex circuits is commonly achieved by solder attachment. These flex circuits are also much more robust and bulkier than a typical implantable device. The standard flex circuit on the market is no less than 0.002 inches in total thickness. The trace metallization is etched copper foil, rather than thin film metal. Chip-scale package (CSP) assembly onto these flex circuits is done in ball-grid array (BGA) format, which uses solder balls attached to input-output contacts on the package base as the interconnect structures. The CSP is aligned to a corresponding metal pad array on the flex circuit and subjected to a solder reflow to create the interconnection. A metallurgical interconnect is achieved by solder wetting. The CSP assembly is then underfilled with an epoxy material to insulate the solder bumps and to provide a pre-load force from the shrinkage of the epoxy. 
     Direct chip attach methods are referred to as chip-on-flex (COF) and chip-on-board (COB). There have been some assemblies that utilize gold wirebonding to interconnect bare, integrated circuits to flexible circuits. The flipchip process is becoming a reliable interconnect method. Flipchip technology originates from IBM&#39;s Controlled Collapse Chip Connection (C4) process, which evolved to solder reflow technique. Flipchip enables minimization of the package footprint, saving valuable space on the circuit, since it does not require a fan out of wirebonds. While there are a variety of flipchip configurations available, solder ball attach is the most common method of forming interconnects. A less developed approach to flipchip bonding is the use of conductive adhesive, such as epoxy or polyimide, bumps to replace solder balls. These bumps are typically silver-filled epoxy or polyimide, although electrically conductive particulate of select biocompatible metal, such as platinum, iridium, titanium, platinum alloys, iridium alloys, or titanium alloys in dust, flake, or powder form, may alternatively be used. This method does not achieve a metallurgical bond, but relies on adhesion. Polymer bump flip chip also requires underfill encapsulation. Conceivably, polymer bump attachment could be used on a chip scale package as well. COB flipchip attach can also be achieved by using gold stud bumps, as an alternative to solder balls. The gold bumps of the chip are bonded to gold contacts on the hard substrate by heat and pressure. A recent development in chip-to-package attachment was introduced by Intel Corporation as Bumpless Build Up Layer (BBUL) technology. In this approach, the package is grown (built up) around the die rather than assembling the die into a pre-made package. BBUL presents numerous advantages in reliability and performance over flipchip. 
     Known technologies for achieving a bond between a flexible circuit and an electronics package suffer from biocompatibility issues. Novel applications of a biomedical implant that utilize a flexible circuit attached to a rigid electronics package require excellent biocompatibility coupled with long term mechanical attachment stability, to assure long lived reliable electrical interconnection. 
     Known deposition techniques for a bond, such as an electrically conductive metal bond or “rivet” are limited to thin layers. Plating is one such known method that does not result in an acceptable bond. It is not known how to plate shiny platinum in layers greater than approximately 1 to 5 microns because the dense platinum layer peels off, probably due to internal stresses. Black platinum lacks the strength to be a good mechanical attachment, and also lack good electrical conductivity. 
     Known techniques for bonding an electronic package to a flex circuit do not result in a hermetic package that is suitable for implantation in living tissue. Therefore, it is desired to have a method of attaching a substrate to a flexible circuit that ensures that the bonded electronic package and flex circuit will function for long-term implant applications in living tissue. 
     SUMMARY OF THE INVENTION 
     An implantable electronic device comprising a hermetic electronics control unit, which is typically mounted on a substrate which is bonded to a flexible circuit by an electroplated platinum or gold interconnection bonding. The resulting electronics assembly is biocompatible and long-lived when implanted in living tissue, such as in an eye or ear. 
     The novel features of the invention are set forth with particularity in the appended claims. The invention will be best understood from the following description when read in conjunction with the accompanying drawings. 
     OBJECTS OF THE INVENTION 
     It is an object of the invention to provide a hermetic, biocompatible electronics package that is attached to a flexible circuit. 
     It is an object of the invention to attach a hermetically sealed electronics package to a flexible circuit for implantation in living tissue. 
     It is an object of the invention to attach a hermetically sealed electronics package to a flexible circuit for implantation in living tissue to transmit electrical signals to living tissue, such as the retina. 
     It is an object of the invention to provide a hermetic, biocompatible electronics package that is attached directly to a substrate. 
     It is an object of the invention to provide a method of bonding a flexible circuit to a substrate with an electroplated interconnection bonding. 
     It is an object of the invention to provide a method of plating platinum or gold as an interconnection bonding. 
     Other objects, advantages and novel features of the present invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawing. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  illustrates a perspective cutaway view of an eye containing a flexible circuit electrode array; 
         FIG. 2  is a side view of an electronics package; 
         FIG. 3  illustrates a cutaway side view of an electronics package; 
         FIG. 4  is a top view of a flex circuit without the electronics package; 
         FIG. 5  presents a side view of a flex circuit with the electronics package; 
         FIG. 6  is a series of illustrations of a flexible circuit being connected to a hybrid substrate using electroplated interconnection bonding; 
         FIG. 7  is an electroplating equipment schema; 
         FIG. 8   a  is a three-electrode electroplating cell schema; 
         FIG. 8   b  is a cross sectional view of an electroplating cell for electroplated interconnecting; 
         FIG. 9  is a plot showing electroplating current density variations of contact pads opening diameters during Au electroplating; 
         FIG. 10  is a plot of showing response current density variation with applied constant electrode voltage during Au electroplating; 
         FIG. 11  is a thickness v. time plot of showing gold electrodeposition rate is constant; 
         FIG. 12  is an optical image of gold electroplated polyimide surface; 
         FIG. 13   a  is a scanning electron micrograph of a polyimide surface before plating magnified 400 times; 
         FIG. 13   b  is a scanning electron micrograph of electrochemically deposited interconnection pads magnified 400 times. 
     
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     The present invention provides a flexible circuit electronics package and a method of bonding a flexible circuit to a hermetic integrated circuit which is useful for a number of applications, including implantation in living tissue as a neural interface, such as a retinal electrode array or an electrical sensor. The device comprises a substrate containing at least one routing (contact), a flexible assembly containing at least one pad, and electroplated bonding between said routing and said pad that bonds said substrate and said flexible assembly together. 
     The tissue paper thin flexible circuit  18 ,  FIG. 1 , transmits electrical signals to the eye by means of electrodes, that are located in a stimulating electrode array  10 , that are in contact with the retina. It is obvious that in addition to a stimulating electrode array or sensing electrode, the electrodes may be contacts connecting to remote electrodes.  FIG. 1  illustrates the electronics control unit  20  connected to a flexible circuit cable  12 . The flexible circuit cable  12  connects the electronics control unit  20  to the stimulating electrode array  10 . The electronics control unit  20  is hermetically sealed. The electronics control unit  20  may be a hermetic ceramic case with electronics inside, or it may be a hermetically sealed integrated circuit sealed by a hermetic coating such as ultra-nano crystalline diamond or deposited ceramic, or any other environmentally sealed electronics package. The stimulating electrode array  10  is implanted on the retina. 
     The flexible circuit ribbon  12  preferably passes through the sclera of the eye. Another embodiment of the invention is the flexible circuit ribbon  12  replaced by alternative means of electrical interconnection, such as fine wires or thin cable. A coil  16 , which detects electronic signals such as of images or to charge the electronics control unit  20  power supply, located outside the eye, near the lens, is connected to the electronics control unit  20 . 
       FIG. 2  illustrates a side view of the hermetic electronics control unit  20  and the input/output contacts  22  that are located on the bottom of the unit  20 . The input/output contacts  22  are bonded in the completed assembly to the flexible circuit  18 . Thick film pad  23  is formed by known thick film technology, such as silk screening or plating. 
       FIG. 3  illustrates a cutaway side view of the hermetic electronics control unit  20 . The pad  23  facilitates attachment of wire  30 , and is preferably comprised of a biocompatible material such as platinum, iridium, or alloys thereof, and is preferably comprised of platinum paste. Wire  30  is preferably bonded to pad  23  by welding. The microelectronics assembly  48  is mounted on the hybrid substrate  44 . Vias  46  pass through the substrate  44  to input/output contacts  22 . Electrical signals arrive by wire  30  and exit the electronics control unit  20  by input/output contacts  22 . 
     A top view of the flexible circuit  18  is illustrated in  FIG. 4 . Electrical signals from the electronics control unit  20  (see  FIG. 3 ) pass into bond pads  32 , which are mounted in bond pad end  33 . Flexible electrically insulating substrate  38  is preferably comprised of polyimide. The signals pass from the bond pads  32  along traces  34 , which pass along flexible circuit ribbon  12  to the stimulating electrode array  10 . The array  10  contains the electrodes  36 , which are implanted to make electrical contact with the retina of the eye, illustrated in  FIG. 1 . An alternative bed of nails embodiment for the electrodes  36  is disclosed by Byers, et al. in U.S. Pat. No. 4,837,049. 
     In  FIG. 5 , the hermetic electronics control unit  20  is illustrated mounted to flexible circuit  18 . In order to assure electrical continuity between the electronics control unit  20  and the flexible circuit  18 , the electrical control unit  20  must be intimately bonded to the flexible circuit  18  on the bond pad end  33 . A cutaway of the electronics control unit  20  ( FIG. 5 ) illustrates a bonded connection  42 . The flexible electrically insulating substrate  38  is very thin and flexible and is able to conform to the curvature of the retina, when implanted thereon. 
     Methods of bonding the flexible insulating substrate  18  to the hermetic electronics control unit  20  are discussed next. 
     Interconnection Bonding by Electroplating Platinum or Gold 
     A preferred embodiment of the invention, illustrated in  FIG. 8   a  shows the method of bonding the hybrid substrate  44  to the flexible circuit  38  using electroplated metal interconnection bonding  37 . The metal of choices contains select biocompatible metal, such as platinum, gold, iridium, titanium, platinum alloys, gold alloys, iridium alloys, or titanium alloys. 
     Step a shows the hybrid substrate  44 , which is preferably a ceramic, such as alumina or silicon, having a total thickness of 0.010-0.015 inches, preferably about 0.012 inches, with patterned vias  46  therethrough. The vias  46  are preferably comprised of frit containing platinum. 
     A routing or contact  35  is patterned on one side of the hybrid substrate  44  by known techniques, such as photolithography or masked deposition. It is equally possible to form routing  35  on both sides of the substrate  44 . The hybrid substrate  44  has an inside surface  45  and an outside surface  49 . The routing  35  will carry electrical signals from the integrated circuit, that is to be added, to the vias  46 , and ultimately will stimulate the retina (not illustrated). The routing  35  is patterned by know processes, such as by masking during deposition or by post-deposition photolithography. The routing  35  is comprised of a biocompatible, electrically conductive, patternable material, such as platinum or gold. 
     Traces  34  on the outside surface  49  of the hybrid substrate  44  are deposited by a known process, such as physical vapor deposition or ion-beam assisted deposition. They may be patterned by a known process, such as by masking during deposition or by post-deposition photolithography. The traces  34  are comprised of an electrically conductive, biocompatible material, such as platinum, gold, platinum alloys, such as platinum-iridium, or titanium-platinum. The traces  34  conduct electrical signals along the flexible circuit  18  and to the stimulating electrode array  10 , which were previously discussed and are illustrated in  FIG. 4 . 
     Step b illustrates formation of the flexible electrically insulating substrate  38  by known techniques, preferably liquid precursor spinning. The flexible electrically insulating substrate  38  is preferably comprised of polyimide or silicone. The flexible electrically insulating substrate electrically insulates the traces  34 . It is also biocompatible when implanted in living tissue. The coating is 4 μm-6 μm, preferably about 5 μm thick. The liquid precursor is spun coated over the traces  34  and the entire outside surface  49  of the hybrid substrate  44 , thereby forming the flexible electrically insulating substrate  38 . The spun coating is cured by known techniques. 
     The contact pads  37  on the flexible substrate surface  38  are deposited by a known process, such as physical vapor deposition or ion-beam assisted deposition. They may be patterned by a known process, such as by masking during deposition or by post-deposition photolithography. The pads  37  are comprised of an electrically conductive, biocompatible material, such as platinum, gold, platinum alloys, such as platinum-iridium, or titanium-platinum. 
     Step c illustrates the flexible assembly  38  is placed closely next to the hybrid substrate  44  in preparation for bonding by electroplating. The pads  37  on the flexible substrate  38  are aligned with the trace contacts  35  on the hybrid substrate  44 . 
     Step d illustrates the bonding  39  which are formed between pads  37  and contacts  35  by electroplating of a biocompatible, electrically conductive material, such as platinum, gold, conducting polymers or platinum alloys, such as platinum-iridium. 
     Step e illustrates the bond area is then underfilled with an adhesive  80 , preferably epoxy. The hybrid substrate  44  preferably contains vias  46  that pass through the thickness of the hybrid substrate  44 , see  FIG. 8 , step (a). Vias  46  are not required to enable this invention. It is preferred that the hybrid substrate  44  be rigid, although alternatively it can a non-rigid substrate. 
     A flexible electrically insulating substrate  38  is preferably comprised of two layers of an electrically insulating material, such as a polymer. Known preferred polymer materials are polyimide, silicone or Parylene. Parylene refers to polyparaxylylene, a known polymer that has excellent implant characteristics. For example, Parylene, manufactured by Specialty Coating Systems (SCS), a division of Cookson Electronic Equipment Group, located in Indianapolis, Ind., is a preferred material. Parylene is available in various forms, such as Parylene C, Parylene D, and Parylene N, each having different properties. The preferred form is Parylene C. 
     Referring to  FIGS. 6 ,  7 ,  8   a  and  8   b , a method to produce plated platinum or gold according to the present invention is described comprising connecting a common electrode  402 , the anode, and a bonding assembly  70 , the cathode, to a voltage or current source, such as a potentiostat  406  with a wave form generator  430  and monitor  428 , preferably an oscilloscope. The common electrode  402 , bonding assembly  70 , a reference electrode  410 , for use as a reference in controlling the power source, which is comprised of a voltage or current source  406  and a waveform generator  430 , and an electroplating solution are placed in a electroplating cell  400  having a means for mixing  414  the electroplating solution. Power may be supplied to the electrodes with constant voltage, constant current, pulsed voltage, scanned voltage or pulsed current to drive the electroplating process. Depending on electrical connection methods, ether polymer substrate  38  or hybrid substrate  44  can be served as the cathode during electroplating. Alternatively, the polymer substrate  38  or hybrid substrate  44  can also be alternated as the cathode or both served as the cathode during electroplating. 
     Referring to  FIGS. 6 and 7 , the electroplating cell  400 , is preferably a 50 ml to 150 ml four neck glass flask or beaker, the common electrode  402 , or anode, is preferably a large surface area platinum wire or platinum sheet, the reference electrode  410  is preferably a Ag/AgCl electrode (silver, silver chloride electrode), the bonding assembly  70 , or cathode, can be any suitable material depending on the application and can be readily chosen by one skilled in the art. Preferable examples of the bonded assembly  70  include, but are not limited to, platinum, iridium, rhodium, gold, tantalum, titanium or niobium, preferably platinum. 
     The means for mixing  414  is preferably a magnetic stirrer ( FIG. 7 ). The plating solution is preferably 20 to 200 millimoles gold sulphite in 50 to 500 millimoles of support electrolyte such as disodium hydrogen phosphate, alkali sulfite or sulfuric acid, but may be derived from any gold salts or other electroplating solution. The preferable plating temperature is approximately 24° to 26° C. 
     The electroplating system for constant voltage control is shown in  FIGS. 6 and 7 . While constant voltage, constant current, pulsed voltage or pulsed current can be used to control the electroplating process, constant voltage control of the plating process is preferable for plating interconnection bonding. The preferable voltage range to produce plated gold of the present invention, which varies from about −0.7 volts to −1.25 volts. The preferable voltage range to produce plated gold is depended on the plating solution pH. At the same plating voltage, the response current density is slight higher for smaller pad openings (see  FIG. 9 ). Generally speaking, the response current density from 0.5 to 40 mA/cm 2 , is dependent on the electroplating voltages, see  FIG. 10 . Higher voltage will have a higher plating rate and a rougher surface. Applying power in this range with the above solution yields a plating rate in the range of about 0.01 μm per minute to 0.5 μm per minute, preferably 0.02 μm per minute to 0.3 μm per minute, which is the preferred range for plating rate of plated gold of the present invention. The average current density may be determined by the equation y=4E −5 e −11x  (R 2 =0.992) where y is the average current density in mA/cm 2  and x is the cathodic (negative) voltage in volts. Constant voltage control also allows an array of interconnection bonding to be plated simultaneously achieving uniform bonding properties. 
     Since low plating rate will give a dense gold layer and provide good adhesion to the seed layer, a step-wise voltage is applied during gold electroplating. A lower voltage is applied initially to plate a thin and dense gold layer. Higher voltage is used later to increased the deposition rate and provide a less dense gold layer to reduce internal stress. Therefore, a thicker layer can be achieved. This is even more critical when one of the seed layer is a thin-film metal. High stress in electroplated layer will lift up the seed layer and cause delaminating and adhesion failure. The plating rates at different voltages are attached are listed in Table 1 below. 
     
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Plating rates at different Voltages 
               
             
          
           
               
                   
                 Voltage 
                 Plating rate 
               
               
                   
                 [volt] 
                 [μm/min] 
               
               
                   
                   
               
             
          
           
               
                   
                 −0.75 
                 0.02 
               
               
                   
                 −0.80 
                 0.03 
               
               
                   
                 −0.90 
                 0.05 
               
               
                   
                 −1.00 
                 0.15 
               
               
                   
                 −1.025 
                 0.26 
               
               
                   
                   
               
             
          
         
       
     
     As plating conditions, including but not limited to the plating solution, surface area of the electrodes, pH, metal concentration, support electrolyte and the presence of additives, are changed the optimal control parameters will change according to basic electroplating principles. 
     SEM micrographs record the surface appearance before plating. The surface is chemically and electrochemically cleaned before plating. 
     The electrodes in the test cell  400  are arranged, so that the bonding assembly  70  (cathode) is physically parallel with the common electrode  402  (anode). The reference electrode  410  is positioned beside the bonding assembly  70 . The plating solution is added to electroplating solution level  411 . The solution is comprised of about 80 millimoles ammonium gold sulfite in about 400 millimoles phosphate buffer solution. The amount of solution used depends on the number of interconnection bonding  39  to be plated. The means for mixing  414 , preferably a magnetic stirrer, is activated as shown in  FIGS. 7 and 8   b.    
     To use the thin-layer cell electroplating technique plating Pt or other metals connects the vias to a thin film electrode array (TFEA) pads. This technique will result in a direct connecting of Pt vias to Pt pads on TFEA without using conductive Pt epoxy. A schematic diagram of electroplating cell is shown in  FIG. 8   a . The assembly is carried out in three steps. 
     (1) Building up the height of Pt pads on TFEA and the height of vias on the ceramic (optional); 
     (2) Aligning the TFEA pads with the vias and keeping the TFEA in parallel with the ceramic and keeping the gap very small by using a spacer to control the gap if necessary; 
     (3) Immersing the assembly in plating solution and plating Pt or other metals to connect the pads with vias. 
     Electrode arrays on TFEA are covered with Cu or other active metals through electroplating or through thin-film process. Cu can be removed by electrochemical and/or chemical process after this process or after all production is completed. The Cu layer also protects the Pt electrode surface from fouling by silicone or other contaminates. Vias with on Ceramic are patterned with Cu or other active metals through the thick-film or thin-film processes. 
       FIG. 8   b  shows a schematic view of an electroplating cell  400  for interconnecting. The Pt electroplating can be controlled by current or potential. An external potentiostat and/or chip  503  can be used for controlling the electroplating processes. Depending on electrical connection methods, either TFEA pads  37  or vias will be served as the cathode during the electroplating. TFEA pads  37  and vias can also be alternated as the cathode or both served as the cathode. Electroplating can be under dc or ac (square-wave) control. A reference electrode  410  is used for potential control and measurements. A Pt common electrode  402  is used as the anode during Pt electro-deposition. Cu layer  501  is applied short-circuiting all electrodes. Glass or ceramic support  500  is provided for TFEA  38 . Substrate  44  is ceramic and contains Pt contacts  35  and is the bottom of the Nb Can with chip  503 . Bonding assembly  70  contains electroplated Pt  39  connecting pads Pt  37  on TFEA  38  and Pt contacts  35  on ceramic  44 . 
     A constant voltage is generated by a potentiostat  406  in the constant voltage plating. In the case of pulse voltage plating, the voltage waveform is generated, preferably with a 1 msec pulse width as a 500 Hz square wave. While for the pulse current plating, the pulse voltage waveform is converted to a current signal through a voltage to current converter  406 . 
     In the case of pulse current, the response electrode voltage versus Ag/AgCl reference electrode is monitored using an oscilloscope (Tektronix TDS220 Oscilloscope). The current amplitude is adjusted so that the cathodic peak voltage reaches about −1.0 volts versus the Ag/AgCl reference electrode  410 . During plating, the electrode voltage tends to decrease with plating time. The current amplitude is frequently adjusted so that the electrode voltage is kept within −0.9 to −1.1 v range versus Ag/AgCl reference electrode  410 . When the specified plating time is reached, the current is eliminated. The cathode is rinsed in deionized water thoroughly. Typical plating time is in the range of about 5 to 120 minutes, preferably 20 to 80 minutes. 
     The plated surface is examined under an optical microscope. Optical photomicrographs are taken at both low and high magnifications to record the image of the surface. The plated samples are profiled with a surface profilometer to measure the dimensions of the plated pads or bindings. The total plated pads or bonding has a total height of about 5 to 20 um and a diameter of 5 to 500 um. The deposition rate is a constant at a given voltage (see  FIG. 11 ). The deposition rate is determined on the gold electroplating of 200 μm openings under a constant voltage of −1.025 volts vs. a Ag/AgCl reference electrode. 
     After plating, the response current or pulsing current amplitudes are averaged for the total plating time and recorded. It has been demonstrated that the current density increases exponentially with increase in cathode electroplating voltages (See  FIG. 10 ). The smaller the sample holes, the higher the current density required (see  FIG. 9 ). 
     An illustrative example of a plated gold contact pads to the present invention are micrographs produced on a Nikon optical microscope (see  FIG. 12 ) and a Scanning Electron Microscope (SEM) at 850× taken by a JEOL JSM5910 microscope,  FIGS. 13   a  and  13   b.    
     The following example is illustrative of electroplating platinum as a contact pads and interconnection binding  37 , according to the present invention. 
     EXAMPLE 
     A flexible electrically insulating substrate comprised of a first substrate  38  and a second substrate  40  of polyimide having a total thickness of 6 μm. It had 16 first substrate holes  39  ( FIG. 6   b ). The pads  37  with 200 μm openings on flex substrate  38  were made out of platinum. 
     The assembly was cleaned by rinsing three times in 10% HCl. It was further prepared by bubbling for 30 seconds at −3.5 V and +4V for 3 cycles in 0.5 M sulphuric acid. Finally, it was rinsed in deionized water. 
     The electroplating set up according to  FIGS. 6 ,  7  and  8   b  was comprised of an electroplating cell  400  that was a 100 ml beaker with an electroplating solution level  411  at about the 75 ml level. The solution was comprised of about 80 millimoles ammonium gold sulfite in about 400 millimoles phosphate buffer solution. 
     The means for mixing  414  was a magnetic stirrer, which was activated. The constant voltage of −0.75 V to −1.025 V with different step time versus Ag/AgCl reference electrode  410  were generated by an EG&amp;G M273 potentiostat. The current is recorded and the current density and charge density were calculated. The response current amplitude was increased within the initial 20 seconds generating a current peak, and then reducing to a long flat current. The electroplating steps and response current densities and charge densities are listed in Table 2 below. 
     
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Parameters of Gold Electroplating on Platinum for 
               
               
                 Interconnection Bonding 
               
             
          
           
               
                 Voltage 
                 Voltage 
                 Time 
                 Average 
                 Average current 
               
               
                 Step 
                 [Volts] 
                 [minutes] 
                 Charge [mC] 
                 density [mA/cm 2 ] 
               
               
                   
               
             
          
           
               
                 1 
                 −0.75 
                 30 
                 −1.66 
                 0.20 
               
               
                 2 
                 −0.80 
                 20 
                 −1.49 
                 0.26 
               
               
                 3 
                 −0.85 
                 10 
                 −0.84 
                 0.30 
               
               
                 4 
                 −0.90 
                 10 
                 −1.33 
                 0.47 
               
               
                 5 
                 −0.95 
                 10 
                 −1.96 
                 0.69 
               
               
                 6 
                 −0.975 
                 10 
                 −2.65 
                 0.94 
               
               
                 7 
                 −1.00 
                 10 
                 −3.58 
                 1.27 
               
               
                 8 
                 −1.025 
                 50 
                 −29.0 
                 2.05 
               
               
                   
               
             
          
         
       
     
     The average current density was 660 mA/cm 2 , which generated response voltages of −0.5 to −0.7 volts, where the voltage was controlled by the current. A 1 msec pulse width square wave was generated by an HP 33120A Arbitrary Waveform Generator. The pulse was converted to a current signal through a voltage to current converter  406 . The pulse current was typically about 1 msec in pulse width as a 500 Hz square wave. The resulting plated gold bonding  39  was about 20 um high tall, with about 15 um of the height extending above the polyimide substrate. The plated platinum gold bonding was strong, and electrically conductive. A pull test on the adhesion of the plated gold layer was carried out. A gold wire is resistively welded on the plated gold surface. All pull tests resulted in the failure of the gold wire to gold surface which indicates that the adhesion of plated gold to the seed layer is good. 
     Scanning Electron Microscope (SEM)/energy dispersive analysis (EDAX™) analysis were performed on the electroplated substrate  38 . SEM micrographs of the plated surface were taken showing its as-plated surface,  FIG. 13   b . Energy dispersed analysis demonstrated that the plated  38  was pure gold, with no detectable oxygen. 
     Accordingly, what has been shown is an improved flexible circuit with an electronics control unit attached thereto, which is suitable for implantation in living tissue and to transmit electrical impulses to the living tissue. Obviously, many modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced other than as specifically described.