Abstract:
The disclosure relates to methods of predicting the effects of therapy, designing/conducting a clinical trial, selecting a subject for a clinical trial, selecting a subject for therapy, monitoring a subject&#39;s responsiveness to therapy, treating a subject, and predicting effects of anti-CD25 therapy.

Description:
FIELD OF THE DISCLOSURE 
       [0001]    This disclosure relates to the diagnosis and treatment of disease. 
       BACKGROUND OF INVENTION 
       [0002]    Cytokines and their receptors are ubiquitous throughout the human immune system and play a vital role in coordinating and controlling the actions of the many different cell types that participate in an immune response. 
         [0003]    Not surprisingly, both agonists and antagonists for many of the cytokine receptors have been developed for medical applications ranging from suppression of the immune response during transplantation, asthma, or autoimmune disease, to enhancement of the immune response against cancer. 
         [0004]    Therapeutic strategies focused on modulating cytokine signaling have met with mixed success at best. Often, there is dramatic heterogeneity in response, with some patients deriving significant benefit and others experiencing toxicity in the absence of clinical activity. Despite extensive research aimed at discovering biomarkers to predict response to cytokine-related therapies, the ability to stratify patients by likelihood of response remains a long felt but unsolved need. 
         [0005]    Predicting clinical activity of cytokine-related therapies has proven challenging in part due to an incomplete or inaccurate understanding of their mechanism of action. Typically, these therapies are developed with the goal of enhancing or inhibiting the signaling of a single type of receptor on a single type of cell. For instance, aldesleukin (recombinant interleukin-2) was developed with the goal of enhancing interleukin (IL)-2 receptor signaling on CD8+ T cells. Similarly, reslizumab (a monoclonal antibody against IL-5) was developed with the goal of inhibiting IL-5 receptor signaling on eosinophils. 
       SUMMARY OF INVENTION 
       [0006]    Here we describe a novel approach to understanding the mechanism of action of cytokine-related therapies, identifying patients likely to respond, increasing response rates, and expanding use. Our approach is based on a principle that heretofore has not been applied to the development of cytokine-related therapies. 
         [0007]    Because many cytokine receptors share common subunits, it is important to understand the effect that a cytokine-receptor agonist or antagonist may have on cytokine receptors other than the targeted one. For instance, in the case of reslizumab, the IL-5 receptor shares a common beta receptor subunit with IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF). By reducing the amount of IL-5 available, reslizumab not only antagonizes IL-5 receptor signaling but may also enhance signaling of IL-3 and/or GM-CSF by increasing the availability of the common beta subunit. 
         [0008]    In addition, because virtually every cytokine receptor is expressed on more than one cell type, it is important to understand the effects of a cytokine-receptor agonist or antagonist on multiple cell types expressing the targeted receptor, and the relative effects of the therapy on different cell types. For instance, in the case of aldesleukin several other cell types (including regulatory T cells and CD56 bright  NK cells) express high affinity IL-2 receptors and in certain patients the aldesleukin may be more likely to affect these cells than the intended CD8 +  T cells. Daclizumab is a therapy designed to antagonize the CD25 subunit of the IL-2 receptor, which is currently in clinical trials for multiple sclerosis. Bielekova and colleagues at the National Institutes of Health (NIH) observed that CD56bright natural killer (NK) cells expand to different extents in different multiple sclerosis (MS) patients following treatment with an anti-CD25 antibody (Daclizumab), and that this expansion is correlated with response to the therapy. [Bielekova, 2006] Monti and colleagues found that Daclizumab enhances T cell responsiveness to IL-7 in vitro, hypothesizing that this effect is caused by an increase in the availability of CD132 [Monti, 2009] 
         [0009]    However, nobody has attempted to quantify or predict this effect, nor has anybody heretofore connected it with CD56bright NK cell expansion following Daclizumab treatment in MS. We identified a third set of findings that are extremely relevant. Hanna and colleagues [Hanna, 2004] found that CD56bright NK cells express CD127, and proliferate in response to IL-7 (unlike CD56dim NK cells). 
         [0010]    Taken together, these three studies strongly suggest that Daclizumab causes CD56bright NK cell expansion in some MS patients by increasing availability of CD132 for the IL-7 receptor. However it is not known and not obvious how to quantify or predict this effect and why it differs from subject to subject. The method described herein was developed to meet that need. 
         [0011]    According to one aspect of the disclosure, a method of predicting the effects of therapy on a subject prior to treatment is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) prior to treatment based on (i); and (iii) predicting the effects of therapy on a subject prior to treatment based on the results of (i)-(ii). 
         [0012]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0013]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0014]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0015]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0016]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0017]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0018]    Examples of cell type(s) include but are not limited to one or more of the following: natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0019]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0020]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0021]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0022]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0023]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligand(s) may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunit(s) and ligand(s) may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunit(s) further comprise IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0024]    In some embodiments, the therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0025]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0026]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0027]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0028]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0029]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0030]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0031]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0032]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0033]    According to another aspect of the disclosure, a method of designing and/or conducting a clinical trial is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) prior to treatment based on (i); and (iii) designing and/or conducting a clinical trial based on the results of (i)-(ii). 
         [0034]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0035]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0036]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0037]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0038]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0039]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0040]    Examples of cell type(s) include but are not limited to one or more of the following: natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0041]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0042]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0043]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0044]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0045]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligand(s) may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunit(s) and ligand(s) may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunit(s) further comprise IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0046]    In some embodiments, the he therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0047]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0048]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0049]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0050]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0051]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0052]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0053]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0054]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0055]    According to yet another aspect of the disclosure, a method of selecting a subject for a clinical trial is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) prior to treatment based on (i); and (iii) selecting a subject for a clinical trial based on the results of (i)-(ii). 
         [0056]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0057]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0058]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0059]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0060]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0061]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0062]    Examples of cell type(s) include but are not limited to one or more of the following natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0063]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0064]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0065]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0066]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0067]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligands may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunit(s) and ligand(s) may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunit(s) further comprise IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0068]    In some embodiments, the therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0069]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0070]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0071]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0072]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0073]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0074]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0075]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0076]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0077]    According to still another aspect of the disclosure, a method of selecting a therapy for a subject is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) prior to treatment based on (i); and (iii) selecting a therapy for a subject based on the results of (i)-(ii). 
         [0078]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0079]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0080]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0081]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0082]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0083]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0084]    Examples of cell type(s) include but are not limited to one or more of the following: natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0085]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0086]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0087]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0088]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0089]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligands may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunit(s) and ligand(s) may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunit(s) further comprise IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0090]    In some embodiments, the therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0091]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0092]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0093]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0094]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0095]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0096]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0097]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0098]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0099]    According to another aspect of the disclosure, a method of monitoring a subject&#39;s responsiveness to therapy is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) subsequent to the initiation of treatment based on (i); and (iii) monitoring a subject&#39;s responsiveness to therapy based on the results of (i)-(ii). 
         [0100]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0101]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0102]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0103]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0104]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0105]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0106]    Examples of cell type(s) include but are not limited to one or more of the following: natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0107]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0108]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0109]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0110]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0111]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligands may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunits and ligands considered may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunits considered further comprises IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0112]    In some embodiments, the he therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0113]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0114]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0115]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0116]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0117]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0118]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0119]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0120]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0121]    According to still another aspect of the disclosure, a method of treating a subject is provided. The method comprises (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of: (a) the therapy&#39;s target receptor subunit(s), (b) receptor subunit(s) that interact with the therapy&#39;s target receptor subunit(s), and/or (c) ligand(s) that interact with one or more of the receptor subunit(s) identified in (a) and (b); (ii) determining a first set of output values, representing the signaling on one or more receptor(s) subsequent to the initiation of treatment based on (i); and (iii) treating a subject based on the results of (i)-(ii). 
         [0122]    The method may further comprise (iv) providing a second set of input values, equal to the first set of input values but wherein the quantity or quantities that is/are expected to be directly altered by the therapy is/are changed to reflect the therapy&#39;s expected effect; (v) determining a second set of output values representing the signaling on one or more receptor(s) after administration of the therapy; and (vi) predicting the effects of therapy on a subject prior to treatment, based on the results of (i)-(v). 
         [0123]    In some embodiments, the therapy comprises an agonist or an antagonist of a receptor or receptor subunit, alters the quantity of ligand available to bind to a receptor or receptor subunit, and/or modulates a pathway triggered by a receptor or receptor subunit. 
         [0124]    In some embodiments, the target receptor subunit(s) comprises: (a) the subunit(s) of the receptor(s) for which the therapy is an agonist or an antagonist, (b) the receptor subunit(s) for which the therapy is an agonist or an antagonist and any subunit(s) that form complexes with that/those receptor subunits, (c) the subunit(s) of the receptor(s) that bind to the ligand whose quantity is altered by the therapy, or (d) receptor subunit(s) that trigger the signaling pathway which the therapy modulates. 
         [0125]    The first set of input values may further comprise receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0126]    In some embodiments, the first set of input values further comprises a receptor subunit(s) that binds to a ligand identified in (i) and/or receptor subunit(s) that interact with receptor subunit(s) identified in (i)(a) and/or (i)(b), and ligand(s) that bind to a receptor subunit(s) that interact with receptor subunits identified in (i)(a) and/or (i)(b). 
         [0127]    In some embodiments, the absolute or relative quantity of receptor subunit(s) is the absolute or relative quantity of receptor subunit(s) present on one or more cell type(s). In some embodiments, the signaling determined in (ii) is compared to the signaling determined in (v) to determine the therapy&#39;s effect on one or more cell type(s). In some embodiments, the effect of one or more cell type(s) comprises proliferation or a cytotoxic response of one or more cell type(s). 
         [0128]    Examples of cell type(s) include but are not limited to one or more of the following: natural killer cell, CD56bright natural killer cell, CD56dim natural killer cell, B cell, eosinophil, T cell, regulatory T cell, naïve regulatory T cell, or memory regulatory T cell. 
         [0129]    In some embodiments, the therapy is (a) an agonist or an antagonist of a cytokine receptor or cytokine receptor subunit, (b) alters the quantity of ligand available to bind to a cytokine receptor or cytokine receptor subunit, or (c) modulates a pathway triggered by a cytokine receptor or cytokine receptor subunit. 
         [0130]    The cytokine receptor or cytokine receptor subunit may comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0131]    In some embodiments, the therapy alters the quantity of ligand available to bind to one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0132]    In some embodiments, the ligand comprises: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. In some of the preferred embodiments, the therapy is a CD25 antagonist. In some of the preferred embodiments, the particular cell type is CD56bright natural killer. 
         [0133]    In some embodiments, the therapy&#39;s effect is proliferation. In some embodiments, the therapy&#39;s target receptor subunits comprise CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), and CD132 (gamma chain). The receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, and IL-21Ralpha (NILR). The ligands may comprise: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunit(s) and ligand(s) may further comprise TSLPR, IL-13Ralpha1 (CD213alpha1), TSLP, and IL-13. In some preferred embodiments, the receptor subunit(s) further comprise IL-13Ralpha2 (CD213alpha2). In some preferred embodiments, the therapy comprises one or more of the following: recombinant IL-2, recombinant IL-4, recombinant IL-7, recombinant IL-9, recombinant IL-15, recombinant IL-21, recombinant TSLP, or recombinant IL-13. 
         [0134]    In some embodiments, the he therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits comprise one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD124 (IL-4Ralpha), CD127 (IL-7Ralpha), CD129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0135]    In some preferred embodiments, the therapy comprises a JAK inhibitor. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise one or more of the following: CD25 (IL-2Ralpha), CD 122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). The ligands may comprise one or more of: IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, TSLP, or IL-13. 
         [0136]    In some preferred embodiments, the therapy (a) is an agonist or an antagonist of one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG or (b) alters the quantity of ligand available to bind to one or more of the following: BAFF-R (BR3), TACI, APRIL, or HSPG. The receptor subunit may comprise: BAFF-R (BR3), TACI, APRIL, or HSPG. The ligand may comprise: BAFF (BLys) or APRIL. 
         [0137]    In some embodiments, the therapy comprises a BAFF antagonist. The particular cell type may be a B cell. In some preferred embodiments, the therapy&#39;s effect is proliferation or antibody production. The therapy&#39;s target receptor subunit and receptor subunits that interact with the therapy&#39;s target receptor subunits may comprise: BAFF-R (BR-3), TACI, APRIL, or HSPG. The ligands may comprise: BAFF (BLyS) or APRIL. 
         [0138]    In some embodiments, the therapy is an agonist or antagonist of one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha or alters the quantity of ligand available to bind to one or more of the following: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, or GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0139]    In some preferred embodiments, the therapy is an anti-IL-5 antibody. The particular cell type may be an eosinophil. The therapy&#39;s effect may be proliferation. The therapy&#39;s target receptor subunits and receptor subunits that interact with the therapy&#39;s target receptor subunit may comprise: IL-5Ralpha, betac, IL-3Ralpha, GM-CSFRalpha. The ligand may comprise: IL-5, IL-3, or GM-CSF. 
         [0140]    In some embodiments, the signaling on one or more receptors comprises the number of receptor-ligand surface complexes. In some embodiments, determining the signaling on one or more receptors utilizes differential equations. In some embodiments, determining the signaling on one or more receptors utilizes binding affinities (dissociation constants). In some embodiments, the signaling on one or more receptors utilizes an analysis of receptor-ligand binding and trafficking dynamics. In some embodiments, determining the signaling on one or more receptors utilizes an analysis of assembly energetics. In some embodiments, determining the signaling on one or more receptors utilizes a computational analysis. In some embodiments, determining providing a set of values comprises assaying a sample from the subject to determine the values. 
         [0141]    Assaying the sample may be conducted using one or more of the following: flow cytometry, mRNA expression analysis, quantitative polymerase chain reaction (qPCR), immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), or radiolabeled binding assays. The sample may be one or more of the following: blood, serum, plasma, lymph, saliva, urine, sweat, mucus, cerebrospinal fluid, amniotic fluid, Pap smear, tissue, tumor, lymph node, biopsy sample, and/or peripheral blood mononuclear lymphocyte (PBMC). 
         [0142]    In some embodiments, the method comprises determining differences in the therapy&#39;s effect on different cell types. In some embodiments, the method comprises performing the method for two or more different cell types simultaneously. 
         [0143]    According to another aspect of the disclosure, a method of predicting the effects of anti-CD25 therapy on a subject prior to treatment is provided. The method comprises: (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) predicting the effects of therapy on a subject prior to treatment based on the results of (i). 
         [0144]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0145]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
         [0146]    According to yet another aspect of the disclosure, a method of designing and/or conducting a clinical trial is provided. The method comprises: (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) designing and/or conducting a clinical trial based on the results of (i). 
         [0147]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0148]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
         [0149]    According to still another aspect of the disclosure, a method of selecting a subject for a clinical trial is provided. The method comprises: (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) selecting a subject for a clinical trial based on the results of (i). 
         [0150]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0151]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
         [0152]    According to still another aspect of the disclosure, a method of selecting a therapy for a subject is provided. The method comprises: (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) selecting a therapy for a subject based on the results of (i). 
         [0153]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0154]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
         [0155]    According to still another aspect of the disclosure, a method of monitoring a subject&#39;s responsiveness to therapy is provided. The method comprises: (i) providing subsequent to initiation of treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) monitoring a subject&#39;s responsiveness to therapy based on the results of (i). 
         [0156]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0157]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
         [0158]    According to yet another aspect of the disclosure, a method of treating a subject is provided. The method comprises: (i) providing prior to treatment a first set of input values comprising the absolute or relative quantity of regulatory T cells in a sample from the subject; and (ii) treating a subject based on the results of (i). 
         [0159]    In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of anti-CD25 that will be administered to a subject. In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of IL-2 and/or IL-7 present in a sample from a subject. In some embodiments, (i) further comprises providing a set of values for the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells present in a sample from a subject. In some embodiments, (i) further comprises the absolute or relative quantity of CD25 and/or CD122 and/or CD 132 and/or CD 127 on one or more cell types. 
         [0160]    In some embodiments, the values provided in (i) are utilized to determine the absolute or relative quantity of memory Tregs and/or naïve Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are utilized to determine how the absolute or relative quantity of IL-2 and/or IL-7 will be distributed among the absolute or relative quantity of Tregs and/or CD56bright NK cells that will remain following a given dose of anti-CD25. In some embodiments, the values provided in (i) are further utilized to determine whether or not the CD56bright NK cells will receive sufficient IL-2 to proliferate. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0161]      FIG. 1  illustrates the receptor subunit and cytokine interactions upon which the model equations are based.  FIG. 1(   a ) shows the portion of the interactions involving the IL-9 receptor.  FIG. 1(   b ) shows the portion of the interactions involving the IL-21 receptor.  FIG. 1(   c ) shows the portion of the interactions involving the IL-4 and IL-13 receptors.  FIG. 1(   d ) shows the portion of the interactions involving the IL-7 and TSLP receptors.  FIG. 1(   e ) shows the portion of the interactions involving the IL-2 receptor.  FIG. 1(   f ) shows the portion of the interactions involving the IL-15 receptor. 
           [0162]      FIG. 2(   a ) shows an initial example of a subject represented by a certain set of input values, for whom the quantity of cytokine is the limiting factor in cytokine signaling. With concentrations of IL-2, IL-7, and IL-21 set to 0.1 nM each, the signaling plateaus occur when each cytokine runs out. When we provide a second set of values in which the amount of CD25 has been reduced to reflect the expected effect of the therapy, as shown in  FIG. 2(   b ), there is little effect on the level of IL-7 or IL-21 signaling, because the concentration of cytokine and not the receptor levels remain the limiting factor. 
           [0163]      FIG. 3(   a ) shows the out put of the model for a different set of input values representing a different patient, in which the concentrations of IL-2, IL-7, and IL-21 are significantly higher at 10 nM each. In this case, when a second set of input values is provided with the levels of CD25 reduced to reflect the effect of an anti-CD25 therapy, as shown in  FIG. 3(   b ), the level of IL-2 signaling drops as expected and the level of IL-7 signaling increases significantly. 
           [0164]      FIG. 4(   a ) illustrates a first subject before (left) and after (right) treatment with a BAFF inhibitor. The subject has lower initial APRIL levels, so the BAFF antagonist will NOT be effective because even after the addition of the BAFF antagonist (as represented by a reduction in BAFF concentration from 0.18 nM to 0.044 nM), the negative signaling (mediated by BAFF:TACI) still exceeds the positive signaling (mediated by APRIL:TACI). In contrast, the second subject (illustrated in  FIG. 4(   b )) has higher initial APRIL levels before treatment (left), so the BAFF antagonist WILL be effective because after the addition of the BAFF antagonist (as represented by a reduction in BAFF concentration from 0.18 nM to 0.044 nM) (right), the negative signaling (mediated by BAFF:TACI) NO LONGER exceeds the positive signaling (mediated by APRIL:TACI). 
       
    
    
     DETAILED DESCRIPTION OF INVENTION 
       [0165]    Aspects of the disclosure relate to predicting the effect of a therapy on a subject prior to treatment. In some embodiments, the effect of a therapy is a binary outcome, i.e. the subject will respond or will not respond to a given therapy. In some embodiments, the effect of a therapy comprises a likelihood of response to a particular therapy, expressed as a percentage or in another format. Alternately, the effect of a therapy may comprise a number expressed in arbitrary units such as a “score.” For instance, a subject has a 50% chance of responding to therapy. As another example, a subject has a score of 40. As another example, said score may be reported in connection with a likelihood of response—for instance, subject has a score of 40, and in clinical trials subjects with a score of 40 had a 70% chance of responding to therapy. The term respond or responsiveness, may refer to partial or complete responses. Responsiveness depends on the condition being treated. In some embodiments, responsiveness comprises the extent to which the therapy is achieving its intended effect, such as, for example, ameliorating the subject from the disease. Responsiveness may be based, for example, on reduction in tumor size, progression free survival, complete and durable response, or any basis known to one of ordinary skill in the art. 
         [0166]    The term therapy is intended to include prophylaxis, amelioration, prevention or cure from the condition being treated. The subject may have not received any therapy before or may have undergone a prior therapy. Treatment comprises administering one or more therapies. 
         [0167]    In some embodiments, the therapy is a single therapeutic/agent, or a therapeutic regimen consisting of multiple therapies/agents. In one embodiment, the therapy comprises a particular therapeutic molecule or molecules to be administered. In some embodiments, therapy comprises a particular molecule, as well as dosing, timing, and other parameters related to the therapy or its administration. In some embodiments, the therapy comprises a therapy already approved by a regulatory agency. In some embodiments, the therapy comprises a therapy under investigation in clinical trials. In some embodiments, the therapy comprises an agonist or an antagonist of a cytokine receptor or a cytokine receptor subunit. In some embodiments, an agonist for a cytokine receptor is a therapy that binds to a cytokine receptor and causes it to generate a signal. In some embodiments, an antagonist for a cytokine receptor is a therapy that blocks the effective functioning of the cytokine receptor, preventing it from generating a signal. 
         [0168]    In some embodiments, the therapy alters the quantity of ligand available to bind to a cytokine receptor or a cytokine receptor subunit. The subunit may be a protein that comprises all or part of a receptor. Often, a subunit is one protein that assembles with one or two other proteins to form a complex that together comprises a receptor. For instance, CD122 is a subunit that assembles with CD132 to form a complex that is the intermediate-affinity IL-2 receptor. 
         [0169]    In some embodiments, the therapy modulates a pathway triggered by a cytokine receptor or a cytokine receptor subunit. In some embodiments, the cytokine receptor or cytokine receptor subunit comprises one or more of the following: CD25 (IL-2Ralpha), CD122 (IL-2Rbeta), CD132 (gamma chain), CD 124 (IL-4Ralpha), CD 127 (IL-7Ralpha), CD 129 (IL-9Ralpha), IL-15Ralpha, IL-21Ralpha (NILR), TSLPR, IL-13Ralpha1 (CD213alpha1), or IL-13Ralpha2 (CD213alpha2). 
         [0170]    In embodiments where the therapy antagonizes a receptor subunit, the expected effect of the therapy comprises a reduction in the quantity of that subunit available to form complexes with other subunits, or to bind to ligand. In embodiments where the therapy alters the quantity of one or more ligands, the expected effect of the therapy comprises an increase or decrease in the quantity of available ligand. 
         [0171]    In some embodiments, input values are numbers that represent something about a subject before he or she is treated. In other words, numbers that correspond to some characteristic of the subject prior to the administration of therapy. For instance, input values could refer to the quantity of a particular receptor subunit on a particular cell type in a subject. In one example, the input values are used by a computer to determine output values. In some embodiments, providing input values are obtained from or provided by a third party. The third party may provide the values in an electronic format such, for example, as a spreadsheet. 
         [0172]    In some embodiments, output values are numbers that are determined using the input values, but that represent a different characteristic of the subject than the input values represent. In other words, numbers that represent something about a subject that is different from what the input values represent, but which depends in some way on the input values. For instance, output values could refer to the number of receptor-ligand surface complexes between IL-7 and the IL-7 receptor, when the input values were the concentration of IL-7 in a subject&#39;s serum, and the number of CD127 receptor subunits on a patient&#39;s CD56bright NK cells. In some embodiments, output values are obtained from or provided by a third party. The third party may provide the values in an electronic format such, for example, as a spreadsheet. 
         [0173]    In some embodiments, signaling on one or more receptor(s) comprises the extent to which a receptor activates a chain or cascade of molecular interactions within a cell in response to the binding of a particular ligand to that receptor. In one embodiment, this is represented by the number of receptor-ligand complexes at a given time. In another embodiment, this is represented as the number of receptor-ligand complexes internalized during a given time interval. 
         [0174]    For a therapy that antagonizes a receptor subunit, in some embodiments, a therapy&#39;s expected expect is a reduction in the quantity of that subunit. For a therapy that alters the quantity of one or more ligands, in some embodiments, a therapy&#39;s expected expect is an increase or decrease in the quantity of available ligand. 
         [0175]    In some embodiments, the therapy alters the quantity of ligand available. In some embodiments, the therapy increases the amount of ligand that is able to bind to receptors on a subject&#39;s cell(s). In some embodiments, the therapy decreases the amount of ligand that is able to bind to receptors on a subject&#39;s cell(s). In some embodiments, decreasing the amount of ligand comprises reducing the amount of ligand by depleting it, or causing an agent to bind to it so that it is no longer able to bind to receptors, or applying a therapy that otherwise lessens the availability of the ligand. In some embodiments, increasing the amount comprises adding additional ligand directly (as in the case of a recombinant cytokine) or applying a therapy that otherwise increases the availability of the ligand. 
         [0176]    In some embodiments, the therapy modulates a pathway triggered by a cytokine receptor or by a cytokine receptor subunit. In some embodiments, the alteration changes the magnitude of signaling that is occurring in a cascade of events that involves a particular molecule. In one example, a JAK3 inhibitor would be considered to modulate the JAK3 pathway because it reduces the magnitude of signaling in the cascade of events that involves JAK3. 
         [0177]    In some embodiments, a signaling pathway comprises a chain or cascade of molecular interactions occurring within a cell in response to the binding of a particular ligand to a particular receptor. If a therapy is designed to interfere with this chain or interactions, then the subunits of the receptor that initiate that chain of interactions comprise the targeted receptor subunits. For instance, if the therapy is a JAK inhibitor, then it targets the JAK signaling pathway which is triggered by the CD 132 receptor subunit, and so the targeted receptor subunits would comprise CD132 and any receptor subunits that form complexes with it. 
         [0178]    In some embodiments, analysis of receptor-ligand binding and trafficking dynamics comprises calculating the extent of signaling that is occurring or will occur on a given receptor as represented by the number of receptor-ligand surface complexes, using measurable input values such as, for example, the number of receptors, the concentration of ligand, and the binding affinity of the ligand for the receptor. Such calculations take into account the forward and reverse rates at which a ligand binds to a receptor, as well as the rates at which ligands, receptors, and their complexes move between the cell surface and endosomes. In other words, generating a set of output values from a set of input values whereby the output values are a number of receptor ligand surface complexes, and the process of generating the output values takes into account the association and dissociation rates of ligand and receptor, and the movement of receptors and complexes between the cell surface and endosomes. 
         [0179]    In some embodiments, analysis assembly dynamics comprises calculating the extent to which receptor subunits come together to form complexes, taking into account the association and dissociation rates with which the various receptor subunits come together to form complexes. In other words, generating a set of output values from a set of input values whereby the output values are a number of receptors composed of two or more particular subunits, and the process of generating the output values takes into account the association and dissociation rates of the various receptor subunits. 
         [0180]    Aspects of the disclosure comprise providing input values for a therapy&#39;s target receptor subunit(s). For a therapy that agonizes or antagonizes a receptor subunit, a therapy&#39;s target receptor subunit comprises the receptor subunit(s) that it agonizes or antagonizes and any receptor subunit(s) that form(s) complexes with that receptor unit. In one embodiment, for an anti-CD25 therapy, the target receptor subunits comprises CD25, CD122, and CD132. For a therapy that alters the quantity of one or more ligands, a therapy&#39;s target receptor subunit comprises the receptor subunit(s) that bind to said ligand(s). For a therapy that modulates a pathway triggered by a receptor or receptor subunit, a therapy&#39;s target receptor subunit comprises the receptor subunit(s) that trigger said pathway. 
         [0181]    Aspects of the disclosure comprise providing input values comprising the absolute or relative quantity of receptor units that interact with the therapy&#39;s target receptor unit. In some embodiments, the interaction comprises binding, allosterically modifying, forming complexes with, or causing conformation change(s). 
         [0182]    The methods described herein have important implications for treating subjects and also for the clinical development of new treatments. Determining whether a subject will benefit from continued treatment or would benefit from a change in treatment is clinically useful. One example of clinical usefulness of the methods of this invention includes identifying subjects who are less likely or more likely to respond to a treatment. The methods are also useful in predicting or determining that a subject would benefit from continued treatment or would benefit from a change in treatment. Health care practitioners and providers select treatment regimens based upon the expected net benefit to the subject. The net benefit is derived from the risk to benefit ratio. The present disclosure permits the determination of whether a subject will benefit from continued treatment or would benefit from a change in treatment, thereby aiding a physician in selecting a treatment. 
         [0183]    Another example of clinical usefulness, in the case of human subjects for example, includes aiding clinical investigators in the selection for clinical trials of subjects with a high likelihood of obtaining a net benefit. It is expected that clinical investigators now will use the present disclosure for determining entry criteria for clinical trials. 
       EXAMPLES 
     Example 1 
     Predicting the Effects of an Anti-CD25 Therapy on a Subject Prior to Treatment 
       [0184]    In one embodiment, the therapy is an antibody against CD25. The therapy&#39;s target receptor subunits are CD25, CD122, and CD132. The ligand that interacts with the therapy&#39;s target receptor subunits is IL-2. The receptor subunits that interact with the therapy&#39;s target receptor subunits are CD124, CD127, CD129, IL-15Ralpha, and IL-21Ralpha. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunits and ligands considered further include TSLPR, IL-13Ralpha1, TSLP, and IL-13. The receptor subunits considered further include IL-13Ralpha2. 
       Methods and Methods: 
       [0185]    In one embodiment, assaying a sample further comprises utilizing the following protocol adapted from [Cesana, 2006], [Venken, 2008], [Hatjiharissi, 2007] 
         [0186]    Blood Collection: Whole blood is collected in heparin-containing Vacutainer tubes (BD or equivalent). 
         [0187]    Determining absolute cell counts: TruCount Tubes (BD Biosciences or equivalent) are utilized to determine accurate cell counts. Cells are stained with fluorescently labeled antibodies against the following eight makers (human): CD3, CD4, CD25, CD127, CD45RA, CD56, CD16, and CD19. Define the five key subsets as follows: 
         [0000]    nTregs: CD4 + CD25 high CD127 low CD45RA − 
 
mTregs: CD4 + CD25 high CD127 low CD45RA + 
 
       CD56 bright  NK: CD56 bright CD16 dim    
     CD56 dim  NK: CD56 dim CD16 bright    
     B Cells: CD 19 +   
       [0188]    Cell counts for each subset are determined using a FACS Aria or FACS Calibur (BD Biosciences or equivalent). 
         [0189]    Isolating peripheral blood mononuclear cells (PBMCs): PBMCs are isolated from whole blood using Ficoll density gradient centrifugation (Histopaque, Sigma-Aldrich; Amersham; or equivalent). 
         [0190]    Cell sorting: Relevant subsets are separated. Cells are stained with fluorescently labeled antibodies against the following eight makers (human): CD3, CD4, CD25, CD127, CD45RA, CD56, CD 16, and CD 19. The five key subsets are defined as follows: 
         [0000]    nTregs: CD4 + CD25 high CD127 low CD45RA − 
 
mTregs: CD4 + CD25 high CD127 low CD45RA + 
 
       CD56 bright  NK: CD56 bright CD16 dim    
     CD56 dim  NK: CD56 dim CD16 bright    
     B Cells: CD 19 +   
       [0191]    Each subset is isolated using a FACS Aria, FACS Calibur (BD Biosciences) or equivalent. 
         [0192]    CELL SURFACE Receptor Quantification: Each of the four FACS-sorted cell subsets collected above is stained with phycoerythrin (PE) conjugated antibodies against one or more of the following targets: CD25, CD122, CD132, CD124, CD127, CD129, IL-15Ralpha, IL-21Ralpha, TSLPR, IL-13Ralpha1, and IL-13Ralpha2. 
         [0193]    One or more of the following reagents (or equivalent) is utilized: 
         [0194]    Monoclonal Anti-Human CD25 Phycoerythrin (Catalog Number FAB1020P: R&amp;D Systems, Minneapolis, Minn. USA) or PE Mouse Anti-Human CD25 (Catalog Number 555432 Becton Dickinson Biosciences, San Jose, Calif. USA) 
         [0195]    Monoclonal Anti-human IL-2Rβ (CD122)-Phycoerythrin (Catalog Number: FAB224P R&amp;D Systems, Minneapolis, Minn. USA) or PE Mouse Anti-Human CD122 (Catalog Number: 554522 Becton Dickinson Biosciences, San Jose, Calif. USA) 
         [0196]    Anti-human CD 132/Common γ chain-Phycoerythrin Monoclonal Antibody (Catalog Number: IC2841P R&amp;D Systems, Minneapolis, Minn. USA) or PE Rat Anti-Human CD132 (Catalog Number 555898 Becton Dickinson Biosciences, San Jose, Calif. USA) or PE Mouse Anti-Human CD132 (Catalog Number 555900 Becton Dickinson Biosciences, San Jose, Calif. USA) 
         [0197]    Monoclonal Anti-human IL-4 Rα (CD124)-Phycoerythrin (Catalog Number: FAB230P R&amp;D Systems, Minneapolis, Minn. USA) or PE Mouse Anti-Human CD124 (Catalog Number 552178 Becton Dickinson Biosciences, San Jose, Calif. USA). 
         [0198]    Monoclonal Anti-human IL-7 Rα/CD127-Phycoerythrin (Catalog Number: FAB306P R&amp;D Systems, Minneapolis, Minn. USA) or PE Mouse Anti-Human CD127 (Catalog Number 557938 Becton Dickinson Biosciences, San Jose, Calif. USA). 
         [0199]    Monoclonal Anti-human IL-9 R-Phycoerythrin (Catalog Number: FAB290P R&amp;D Systems, Minneapolis, Minn. USA) or PE Anti-Human IL-9 Receptor (CD129) (Catalog Number 310403 BioLegend, San Diego, Calif. USA). 
         [0200]    Monoclonal Anti-human IL-15 Rα-Phycoerythrin (Catalog Number: FAB1471P R&amp;D Systems, Minneapolis, Minn. USA) or PE Anti-human CD359 (IL-15Ra) Antibody (Catalog Number 330207 BioLegend, San Diego, Calif. USA). 
         [0201]    Monoclonal Anti-human IL-21 R-Phycoerythrin (Catalog Number: FAB9911P R&amp;D Systems, Minneapolis, Minn. USA) or PE Mouse Anti-Human IL-21R (Catalog Number 560264 Becton Dickinson Biosciences, San Jose, Calif. USA) or PE Anti-human CD360 (IL-21R) Antibody (Catalog Number 347805, BioLegend, San Diego, Calif. USA). 
         [0202]    PE Anti-human TSLPR (TSLP-R) Antibody (Catalog Number 322805, BioLegend, San Diego, Calif. USA) or Phycoerythrin (PE) anti-human TSLP Receptor (TSLPR, thymic stromal derived lymphopoietin receptor) (Catalog Number 12-5499, eBioscience, San Diego, Calif. USA). 
         [0203]    Monoclonal Anti-human IL-13 Rα1-Phycoerythrin (Catalog Number: FAB1462P R&amp;D Systems, Minneapolis, Minn. USA). 
         [0204]    IL13 receptor alpha 2 antibody [B-D13] (Phycoerythrin) (Catalog Number: ab27415 or ab34931, Abcam, Cambridge, Mass. USA) 
         [0205]    The number of receptors per cell for each receptor type are quantified in each cell subset, calibrating using QuantiBRITE PE Phycoerythrin Fluorescence Quantitation Beads (Catalog Number 340495: Becton Dickinson Immunocytometry Systems, San Jose, Calif. USA) using techniques described in [Pannu, 2001] and [Hatjiharissi, 2007]. 
         [0206]    Alternately, a technique that determines molecules of equivalent soluble fluorescein (MESF) is used to determine receptor quantities. 
         [0207]    Intracellular and Cell Surface Receptor Quantification: After quantifying only the cell surface receptors using the above procedure, the cells are permeabilized using CytoFix/Cytoperm (Catalog Number 554722, Becton Dickinson Biosciences, San Jose, Calif. USA) or equivalent. Then the above “Cell Surface Receptor Quantification” procedure is repeated, but in this case will yield the total (intracellular+cell surface) receptor levels. The intracellular levels is then calculated for each receptor by subtracting the surface levels from the total levels as in [Hodge, 2000]. 
         [0208]    Measure Cytokine Levels: Serum cytokine levels are determined as in [Sabatino, 2008] using a SearchLight multiplex array (Aushon Biosystems, Billerica, Mass. USA) to measure the concentrations of IL-2, IL-4, IL-7, IL-9, IL-15, IL-21, IL-13, and TSLP in the patient&#39;s serum. While IL-21 is not currently available, it can be measured separately using an ELISA kit such as the Human IL-21 ELISA MAX™ Deluxe (Catalog Number 433804, BioLegend, San Diego, Calif. USA) or the Human IL-21 ELISA Ready-SET-Go! Set (Catalog Number 88-7216, eBioscience, San Diego, Calif. USA). 
         [0209]    In one embodiment, the measurements resulting from the above protocols comprise the initial conditions that are input into the computational model as defined in the table below. In this example, Cell Type A is defined to be CD56bright NK cells, but in other embodiments it could be other cell types, or repeated for multiple cell types. 
         [0000]    
       
         
               
             
               
               
             
           
               
                   
               
               
                 Table of Measured Parameters: Initial Conditions (t = 0) 
               
             
          
           
               
                 parameter 
                 Definition 
               
               
                   
               
               
                 R S   CellTypeA:CD25 [t = 0] 
                 Surface CD25 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:CD122 [t = 0] 
                 Surface CD122 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:CD132 [t = 0] 
                 Surface CD132 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:IL4RA [t = 0] 
                 Surface CD124 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:CD127 [t = 0] 
                 Surface CD127 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:IL9R [t = 0] 
                 Surface CD129 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:IL15RA [t = 0] 
                 Surface IL-15Ralpha (CD359) receptor 
               
               
                   
                 subunits per Cell Type A 
               
               
                 R S   CellTypeA:IL21R [t = 0] 
                 Surface IL-21R (CD360) receptor subunits per 
               
               
                   
                 Cell Type A 
               
               
                 R S   CellTypeA:TSLPR [t = 0] 
                 Surface TSLP receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R S   CellTypeA:IL13Ra1 [t = 0] 
                 Surface IL-13Ralpha1 receptor subunits per 
               
               
                   
                 Cell Type A 
               
               
                 R S   CellTypeA:IL13Ra2 [t = 0] 
                 Surface IL-13Ralpha2 receptor subunits per 
               
               
                   
                 Cell Type A 
               
               
                 R i   CellTypeA:CD25 [t = 0] 
                 Intracellular CD25 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:CD122 [t = 0] 
                 Intracellular CD122 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:CD132 [t = 0] 
                 Intracellular CD132 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:IL4RA [t = 0] 
                 Intracellular CD124 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:CD127 [t = 0] 
                 Intracellular CD127 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:IL9R [t = 0] 
                 Intracellular CD129 receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:IL15RA [t = 0] 
                 Intracellular IL-15Ralpha (CD359) receptor 
               
               
                   
                 subunits per Cell Type A 
               
               
                 R i   CellTypeA:IL21R [t = 0] 
                 Intracellular IL-21R (CD360) receptor subunits 
               
               
                   
                 per Cell Type A 
               
               
                 R i   CellTypeA:TSLPR [t = 0] 
                 Intracellular TSLP receptor subunits per Cell 
               
               
                   
                 Type A 
               
               
                 R i   CellTypeA:IL13Ra1 [t = 0] 
                 Intracellular IL-13Ralpha1 receptor subunits 
               
               
                   
                 per Cell Type A 
               
               
                 R i   CellTypeA:IL13Ra2 [t = 0] 
                 Intracellular IL-13Ralpha2 receptor subunits 
               
               
                   
                 per Cell Type A 
               
               
                 L IL2 [t = 0] 
                 Concentration of IL-2 in serum 
               
               
                 L IL4 [t = 0] 
                 Concentration of IL-4 in serum 
               
               
                 L IL7 [t = 0] 
                 Concentration of IL-7 in serum 
               
               
                 L IL9 [t = 0] 
                 Concentration of IL-9 in serum 
               
               
                 L IL15 [t = 0] 
                 Concentration of IL-15 in serum 
               
               
                 L IL21 [t = 0] 
                 Concentration of IL-21 in serum 
               
               
                 L IL13 [t = 0] 
                 Concentration of IL-13 in serum 
               
               
                 L ILTSLP [t = 0] 
                 Concentration of TSLP in serum 
               
               
                 Y CellTypeA [t = 0] 
                 Cell Type A starting cell count 
               
               
                   
               
             
          
         
       
     
         [0210]    In one embodiment, the method comprises assessing these measured values using a computational model. Here we discuss the background for said model. 
         [0211]    Careful work by Smith, beginning with a key study in 1984 [Cantrell, 1984] and continuing to today, has led to the quantal theory of immunology. This theory predicts that T cells or other lymphocytes will proliferate once the number of formed receptor-ligand complexes, integrated over time, crosses a certain threshold. In the quantal theory, the parameters having the most impact on proliferation time are the number of receptors per cell, the binding affinity of those receptors, and the number of cells present. In addition, the binding and trafficking dynamics have a significant impact. This includes internalization rates, degradation rates, recycling rates, and so forth. 
         [0212]    Lauffenburger and colleagues developed computational models of these binding and trafficking dynamics, and demonstrated the ability to predict CD8+ T cell proliferation in vitro in response to IL-2 [Fallon, 2000]. While Lauffenburger references Smith&#39;s work, he uses a proliferation rate that is based on the instantaneous number of receptor-ligand surface complexes, rather than the integral of these complexes over time. This was a reasonable approximation for the situation that Lauffenburger was modeling, in which proliferation had little effect on the outcome, but for modeling cell proliferation following high dose IL-2-induced lymphopenia it is critical to capture Smith&#39;s findings more directly. We therefore substitute a zero proliferation rate, solve for the instantaneous number of receptor-ligand complexes for each receptor type, sum this value over time, and determine which receptor type first reaches the threshold number of complexes, and when. 
         [0213]    Lauffenburger&#39;s model focuses on a single receptor type (IL-2). We made the non-obvious decision to build a model of multiple receptor types competing for the same CD 132 subunit. It is highly non-obvious that such an approach would result in an effective means to predict response to therapy. 
         [0214]      FIG. 1  illustrates the receptor subunit and cytokine interactions upon which the model equations are based.  FIG. 1(   a ) shows the portion of the interactions involving the IL-9 receptor.  FIG. 1(   b ) shows the portion of the interactions involving the IL-21 receptor.  FIG. 1(   c ) shows the portion of the interactions involving the IL-4 and IL-13 receptors.  FIG. 1(   d ) shows the portion of the interactions involving the IL-7 and TSLP receptors.  FIG. 1(   e ) shows the portion of the interactions involving the IL-2 receptor.  FIG. 1(   f ) shows the portion of the interactions involving the IL-15 receptor. 
         [0215]    In one particular embodiment, the following format is used to define relevant parameters to represent interactions: 
         [0000]    kf_X_Y is defined as the surface forward rate constant of X binding to Y.
 
kr_X_Y is defined as the surface reverse rate constant of X binding to Y.
 
kfe_X_Y is defined as the internal forward rate constant of X binding to Y.
 
kre_X_Y is defined as the internal reverse rate constant of X binding to Y.
 
ksyn_X_Y is defined as the rate at which X in synthesized in response to the binding event indicated in Y.
 
kt_celltypea_X is defined as the constitutive internalization rate of X on cell type a.
 
ke_celltypea_X is defined as the internalization rate of X on cell type a.
 
kh_celltypea_X is defined as the degradation rate of X on cell type a.
 
kx_celltypea_X is defined as the recycling rate of X on cell type a.
 
vs_celltypea_X is defined as the rate at which X is synthesized on cell type a.
 
ve is defined as the total endosomal volume.
 
na is defined as Avogadro&#39;s Number in nM.
 
veff is defined as an effective volume in order to modify the three dimensional equations to properly represent the two dimensional interactions between receptor subunits in a membrane.
 
         [0216]    In one particular embodiment, using the above format to define parameters, the following parameters are provided from literature values as indicated, although in other embodiments other values may be used or the values may be measured: 
         [0217]    ve=10̂-14;% L/cell [Fallon, 2000]total endosomal volume 
         [0218]    na=6.02e23/(10̂9); % Avogadro&#39;s Number, units in nM 
         [0219]    veff=(4*pi*(5e-6)̂2)*(1e-9)*1000;% effective volume (liters per cell) for 2D 1000 L/m̂3. 5 um radius. 10 nm height. 
         [0220]    kf_il2_cd132=0;% “Not detectable” [Taniguchi, 1993] “No interaction” [Rickert, 2004]
       kr_il2_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il2_cd132=0;%   kre_il2_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0224]    kr_cd25_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd25_cd122=(1/(na*veff)*kr_cd25_cd122/278;% nM̂-1 min ̂-1 [Rickert, 2004]   kfe_cd25_cd122=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_cd25_cd122=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates       
 
         [0228]    kf_cd122_cd132=(1/(na*veff))*0;% No binding detected by [Rickert, 2004]
       kr_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd122_cd132=0;%   kre_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0232]    kr_il2_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il2_cd122_cd132=kr_il2_cd122_cd132/1.1;% Exact number scaled from [Fallon, 2000]. Range confirmed by [Voss, 1992]   kre_il2_cd122_cd132=8*kr_il2_cd122_cd132;% [Fallon, 2000]   kfe_il2_cd122_cd132=kre_il2_cd122_cd132/1;%[Fallon, 2000] expressed in nM instead of pM       
 
         [0236]    kr_il2_cd25_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il2_cd25_cd122_cd132=kr_il2_cd25_cd122_cd132/0.011;% Exact number from [Fallon, 2000]. Range confirmed by [Voss, 1992]   kfe_il2_cd25_cd122_cd132=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_il2_cd25_cd122_cd132=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates       
 
         [0240]    kf_cd25_cd122_cd132=(1/(na*veff))*0;% Not discussed by [Rickert, 2004]—assume not favorable
       kr_cd25_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd25_cd122_cd132=0;%   kre_cd25_cd122_cd132=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates       
 
         [0244]    kr_il2_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il2_cd122=kr_il2_cd122/144;% nMA-1 min ̂-1 [Rickert, 2004] BUT [Myszka, 1996] says 450 nM—2 citations   kre_il2_cd122=8*kr_il2_cd122;% Use same proportions as IL-2 binding to CD122/CD132 complex from [Fallon, 2000]   kfe_il2_cd122=kre_il2_cd122/1;% Use same proportions as IL-2 binding to CD122/CD132 complex from [Fallon, 2000]       
 
         [0248]    kr_cd122_il2_cd25=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]=0;%
       kf_cd122_il2_cd25=(1/(na*veff)*kr_cd122_il2_cd25/63;% nMA-1 min ̂-1 [Rickert, 2004]   kfe_cd122_il2_cd25=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_cd122_il2_cd25=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates, so no complexes       
 
         [0252]    kr_il2_cd25=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il2_cd25=kr_il2_cd25/10;% nMA-1 min ̂-1 [Rickert, 2004] [Myszka, 1996] agrees   kfe_il2_cd25=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_il2_cd25=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates, so no complexes       
 
         [0256]    kf_cd25_il2_cd122_cd132=(1/(na*veff)*kf_il2_cd25;% Assume same binding affinity as CD25 to free IL-2. Stickiest interaction, and assume CD122/CD132 doesn&#39;t significantly add or interfere.
       kr_cd25_il2_cd122_cd132=kr_il2_cd25;% min ̂-1, Assume same binding affinity as CD25 to free IL-2   kfe_cd25_il2_cd122_cd132=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_cd25_il2_cd122_cd132=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates, so no complexes       
 
         [0260]    kr_il2_cd25_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il2_cd25_cd122=kr_il2_cd25_cd122/0.4;% nM̂-1 min ̂-1, [Myska, 1996]—0.2-0.6 nM   kfe_il2_cd25_cd122=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_il2_cd25_cd122=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates, so no complexes       
 
         [0264]    kf_cd25_il2_cd122=(1/(na*veff)*kf_il2_cd25;% Assume same binding affinity as IL-2 to free CD25. Stickiest interaction, and assume CD122 doesn&#39;t significantly add or interfere.
       kr_cd25_il2_cd122=kr_il2_cd25;% min ̂-1, Assume same binding affinity as IL-2 to free CD25. Stickiest interaction, and assume CD122 doesn&#39;t significantly add or interfere.   kfe_cd25_il2_cd122=0;% Does not occur—[Fallon, 2000]—all CD25 dissociates   kre_cd25_il2_cd122=1000000;% Set arbitrarily high because—[Fallon, 2000]—all CD25 dissociates, so no complexes       
 
         [0268]    kf_il15_cd122=kf_il2_cd122;% Assume similar to IL-2
       kr_il15_cd122=kr_il2_cd122;% min ̂-1, Assume similar to IL-2   kfe_il15_cd122=kfe_il2_cd122;% Assume similar to IL-2   kre_il15_cd122=kre_il2_cd122;% Assume similar to IL-2       
 
         [0272]    kf_il15_cd122_cd132=kf_il2_cd122_cd132;% CRUCIAL INTERACTION—PRESENTED IN TRANS FROM OTHER CELLS. 1.1 nm Similar affinity to IL-2 for CD122/CD132 [Vamosi, 2004]
       kr_il15_cd122_cd132=kr_il2_cd122_cd132;% 0.0138 min ̂-1   kfe_il15_cd122_cd132=kfe_il2_cd122_cd132;%   kre_il15_cd122_cd132=kre_il2_cd122_cd132;%       
 
         [0276]    kr_il15_il15r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il15_il5r=kr_il15_il5r/0.05;% nMA-1 min ̂-1 (KD=5×10̂-11) [Mortier, 2008]   kre_il15_il5r=8*kr_il15_il15r;% min ̂-1, Use same proportions as IL-2 binding to CD122/CD132 complex from [Fallon, 2000]   kfe_il15_il15r=kre_il15_il15r/1;% Use same proportions as IL-2 binding to CD122/CD132 complex from [Fallon, 2000]       
 
         [0280]    kf_il15il15r_cd122_cd132=kf_il15_il15r;% Same for Trimeric and IL-15Ralpha [Vamosi, 2004]
       kr_il15_il15r_cd122_cd132=kr_il15_il15r;% min ̂-1   kfe_il15_il15r_cd122_cd132=kfe_il15_il15r;%   kre_il15_il15r_cd122_cd132=kre_il15_il15r;% min ̂-1       
 
         [0284]    kf_cd122_cd132_il15_il15r=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd122_cd132_il15_il15r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd122_cd132_il15_il15r=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd122_cd132_il15_il15r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0288]    kf_il15r_cd122_cd132=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il15r_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il15r_cd122_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il15r_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0292]    kf_il15r_cd122=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0296]    kf_il15il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il15_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il15_il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il15_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0300]    kf_cd122_il15_il15r=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd122_il15_il15r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd122_il15_il15r=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd122_il15il15r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0304]    kf_il15r_il15_cd122=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il15r_il15_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il15r_il15_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il15r_il15_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0308]    kf_il15r_il15_cd122_cd132=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il15r_il15_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il15r_il15_cd122_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il15r_il15_cd122_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0312]    kf_il15_cd132=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006] 
         [0313]    kr_il15_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0314]    kfe_il15_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006] 
         [0315]    kre_il15_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0316]    %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% IL-7/TSLP 
         [0317]    %kf_cd127_cd132=1;% nM̂-1 min ̂-1 [Palmer, 2008] 
         [0318]    kf_cd127_cd132=(1/(na*veff))*0;% nMA-1 min ̂-1 ASSUME UNLIKELY (temp)
       kr_cd127_cd132=0.1;% min ̂-1, [Palmer, 2008]   %kr_cd127_cd132=0.1;% min ̂-1, [Palmer, 2008]   kfe_cd127_cd132=0;%   kre_cd127_cd132=0;%       
 
         [0323]    kr_il7_cd127_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il7_cd127_cd132=kr_il7_cd127_cd132/0.08;% nMA-1 min ̂-1 80 pM [Olosz, 2000]—   kfe_il7_cd127_cd132=0;%   kre_il7_cd127_cd132=0;%       
 
         [0327]    kf_cd127_tslpr=(1/(na*veff))*0;%
       kr_cd127_tslpr=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd127_tslpr=0;%   kre_cd127_tslpr=0;%       
 
         [0331]    kr_tslp_cd127_tslpr=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_tslp_cd127_tslpr=kr_tslp_cd127_tslpr/13;% nM̂-1 min ̂-1 [Pandey, 2000]   kfe_tslp_cd127_tslpr=0;%   kre_tslp_cd127_tslpr=0;%       
 
         [0335]    kr_il7_cd127=60*(1e-1)*(4e-3)/(2.5e-3+4.1e-3);% min ̂-1 [McElroy, 2010] GLYCOSYLATED, OTHERWISE=kr_il7_cd127=60*(1.7e-2)*(1.2e-3)/(4.2e-3+1.2e-3) unglycosylated
       kf_il7_cd127=kr_il7_cd127/56;% nM̂-1 min ̂-1 GLYCOSYLATED, OTHERWISE=kr_il7_cd127/18000 (18 uM) unglycosylated—[Olosz, 2000]: 200 pM   kfe_il7_cd127=0;%   kre_il7_cd127=0;%       
 
         [0339]    kr_cd127_tslp_tslpr=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd127_tslp_tslpr=(1/(na*veff))*0;%   kfe_cd127_tslp_tslpr=0;%   kre_cd127_tslp_tslpr=0;%       
 
         [0343]    kf_tslp_tslpr=0;% [Pandey, 2000]
       kr_tslp_tslpr=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_tslp_tslpr=0;%   kre_tslp_tslpr=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0347]    %%%%%%%%%%%%%%%%% IL-4/IL-13 
         [0348]    kf_il4ra_cd132=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_il4ra_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il4ra_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il4ra_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0352]    kf_cd124_cd132=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd124_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd124_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd124_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0356]    kf_cd124_cd213=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd124_cd213=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd124_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd124_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0360]    kr_il4_cd124_cd132=6.6;% min ̂-1, (0.11 ŝ-1 [Andrews, 2006])
       kf_il4_cd124_cd132=kr_il4_cd124_cd132/1100;% nMA-1 min ̂-1 (KD=1.1 uM: [Andrews, 2006])   kfe_il4_cd124_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il4_cd124_cd132=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0364]    kr_il13_cd213=(60*1.41e-3);% min ̂-1, IL-13 for shIL 13-Ra1 [Andrews, 2002]
       kf_il13_cd213=kr_il13_cd213/37.8;% nMA-1 min ̂-1, [Andrews, 2002] [Kraich, 2006 agrees]   kfe_il13_cd213=0;%   kre_il13_cd213=0;%       
 
         [0368]    kf_il13_cd124_cd213=kf_il13_cd213;% “The ka value obtained . . . was similar to that obtained for the binding of 1′-13 to IL-13Ra1 [Andrews, 2002]
       kr_il13_cd124_cd213=(0.495)*kf_il13_cd124_cd213;% min ̂-1, 495 pM [Andrews, 2002]   kfe_il13_cd124_cd213=0;%   kre_il13_cd124_cd213=0;%       
 
         [0372]    kr_il4_cd124=(60*1.67e-3);% min ̂-1, (1.67e-3 5̂-1 [Andrews, 2006])
       kf_il4_cd124=kr_il4_cd124/(0.150);% nMA-1 min ̂-1, (Zhang, 2003 says 150 pM, Kraich, 2006 agrees) ([Andrews, 2006] says 382 pM)   kfe_il4_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il4_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0376]    kf_il4_cd124_cd213=kf_il4_cd124;% “presence of IL-13Ra1 had no detectable effect on the binding of IL-4 to IL-4Ra” [Andrews, 2002]
       kr_il4_cd124_cd213=kr_il4_cd124;% min ̂-1, “presence of IL-13Ra1 had no detectable effect on the binding of IL-4 to IL-4Ra” [Andrews, 2002]   kfe_il4_cd124_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il4_cd124_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0380]    kf_il13_cd124=0;% NO DIRECT BINDING OBSERVED [Andrews, 2002]
       kr_il13_cd124=1;% min ̂-1, Placeholder, no direct binding observed [Andrews, 2002]   kfe_il13_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_il13_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0384]    kf_cd124_il4_cd213=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd124_il4_cd213=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd124_il4_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd124_il4_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0388]    kr_cd124_il13_cd213=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd124_il13_cd213=(1/(na*veff)*kr_cd124_il13_cd213/150;% [Kraich, 2006]   kfe_cd124_il13_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd124_il13_cd213=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0392]    kf_il4_cd213=0;% NO DIRECT BINDING OBSERVED [Andrews, 2006] or KD=2500 nm [Kraich, 2006]
       kr_il4_cd213=1;% min ̂-1, Placeholder, no direct binding observed [Andrews, 2006]   kfe_il4_cd213=0;%   kre_il4_cd213=0;%       
 
         [0396]    kf_cd213_il13_cd124=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd213_il13_cd124=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd213_il13_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd213_il13_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0400]    kr_cd213_il4_cd124=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd213_il4_cd124=(1/(na*veff)*kr_cd213_il4_cd124/(1200);% [Kraich, 2006]   kfe_cd213_il4_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd213_il4_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0404]    kr_il13_il3ra2=(60*1.39e-4);% min ̂-1, IL13 to shIl-13Ra2 [Andrews, 2002]
       kf_il13il13ra2=kr_il13_il3ra2/2.49;% nMA-1 min ̂-1 [Andrews, 2002]   kfe_il13_il3ra2=0;%   kre_il13_il3ra2=0;%       
 
         [0408]    %%%%%%%%%%%%%%%%%%%% IL-9 
         [0409]    %kf_il9r_cd132=0;% 
         [0410]    %kr_il9r_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0411]    %kfe_il9r_cd132=0;% 
         [0412]    %kre_il9r_cd132=0;% 
         [0413]    kf_cd129_cd132=(1/(na*veff))*0;%
       kr_cd129_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd129_cd132=0;%   kre_cd129_cd132=0;%       
 
         [0417]    kr_il9_cd129_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_il9_cd129_cd132=kr_il9_cd129_cd132/0.1;% nM̂-1 min ̂-1 Kd=100 pM [De Smedt, 2000]   kfe_il9_cd129_cd132=0;%   kre_il9_cd129_cd132=0;%       
 
         [0421]    kf_il9_cd129=0;%
       kr_il9_cd129=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il9_cd129=0;%   kre_il9_cd129=0;%       
 
         [0425]    %%%%%%%%%%%%%%%%%%%%IL-21 
         [0426]    kf_il21_il21r_cd132=0;%
       kr_il21_il21r_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il21_il21r_cd132=0;%   kre_il21_il21r_cd132=0;%       
 
         [0430]    kf_il21r_cd132=(1/(na*veff))*0;%
       kr_il21r_cd132=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_il21r_cd132=0;%   kre_il21r_cd132=0;%       
 
         [0434]    kr_il21_il21r=(60*0.003);% min ̂-1, [Zhang, 2003]
       kf_il21_il21r=kr_il21_il21r/(0.070);% nM̂-1 min ̂-1 70 pM [Zhang 2003]   kfe_il21_il21r=0;%   kre_il21_il21r=0;%       
 
         [0438]    %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% %%% COMPETITION FOR FREE CD132 
         [0439]    %kf_cd132_il9_il9r=0;% 
         [0440]    %kr_cd132_il9_il9r=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0441]    %kfe_cd132_il9_il9r=0;% 
         [0442]    %kre_cd132_il9_il9r=0;% 
         [0443]    kf_cd132_il9_cd129=(1/(na*veff))*0;%
       kr_cd132_il9_cd129=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd132_il9_cd129=0;%   kre_cd132_il9_cd129=0;%       
 
         [0447]    kf_cd132_il4_il4ra=(1/(na*veff))*0;%TEMP leave as zero [Bielekova, 2006]
       kr_cd132_il4_il4ra=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd132_il4_il4ra=0;%TEMP leave as zero [Bielekova, 2006]   kre_cd132_il4_il4ra=0;%TEMP leave as zero b/c [Bielekova, 2006]       
 
         [0451]    kr_cd132_il21_il21r=(60*0.01);% min ̂-1, [Zhang, 2003]
       kf_cd132_il21_il21r=(1/(na*veff)*kr_cd132_il21_il21r/200;% nMA-1 min ̂-1 [Zhang, 2003]   kfe_cd132_il21_il21r=0;% kre_cd132_il21_il21r=0;%   %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%       
 
         [0455]    kr_cd132_il7_cd127=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd132_il7_cd127=(1/(na*veff)*kr_cd132_il7_cd127/12;% nM̂-1 min ̂-1 TEMP—assume same as IL-2[Rickert, 2004]   kfe_cd132_il7_cd127=0;%   kre_cd132_il7_cd127=0.0138;%       
 
         [0459]    kr_cd132_il2_cd25_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd132_il2_cd25_cd122=(1/(na*veff)*kr_cd132_il2_cd25_cd122/12;%nM̂-1 min ̂-1 [Rickert, 2004]   kfe_cd132_il2_cd25_cd122=0;%   kre_cd132_il2_cd25_cd122=0.0138;%       
 
         [0463]    kr_cd132_il2_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd132_il2_cd122=(1/(na*veff)*kr_cd132_il2_cd122/1.5;% nMA-1 min ̂-1 [Rickert, 2004]   kfe_cd132_il2_cd122=0;%   kre_cd132_il2_cd122=0.0138;%%%%%CHANGE   kf_cd132_cd25_cd122=(1/(na*veff))*0;% [Rickert, 2004]       
 
         [0468]    kr_cd132_cd25_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kfe_cd132_cd25_cd122=0;%   kre_cd132_cd25_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]       
 
         [0471]    kr_cd132_il4_cd124=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]
       kf_cd132_il4_cd124=(1/(na*veff)*kr_cd132_il4_cd124/4000;% 4 uM [Zhang, 2003]—no on/off rates given   kfe_cd132_il4_cd124=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd132_il4_cd124=0.0138;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0475]    kf_cd132_il15r_cd122=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd132_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd132_il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd132_il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0479]    kf_cd132_il15_il15r_cd122=(1/(na*veff))*0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]
       kr_cd132_il15_il15r_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd132_il15_il15r_cd122=0;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]   kre_cd132_il5il15r_cd122=0.0138;%TEMP leave as zero b/c “Neither population expressed IL-4RA and IL-15RA chains” [Bielekova, 2006]       
 
         [0483]    kf_cd132_il15_cd122=(1/(na*veff))*0;%
       kr_cd132_il15_cd122=0.0138;% min ̂-1, TEMP IL-2 [Fallon, 2000]   kfe_cd132_il15_cd122=0;%   kre_cd132_il15_cd122=0.0138;%       
 
         [0487]    %FACTORS AFFECTING 
       SYNTHESIS %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% &amp;&amp;&amp;&amp;&amp;&amp; 
       [0488]    ksyn_tslpr_il2_CD25=0;% 
         [0489]    ksyn_tslpr_il2_CD 122=0; % 
         [0490]    ksyn_tslpr_il4 — 213=0;% 
         [0491]    ksyn_tslpr_il4 — 132=0;% 
         [0492]    ksyn_tslpr_il7=0;% 
         [0493]    ksyn_tslpr_il9=0;% 
         [0494]    ksyn_tslpr_il13=0;% 
         [0495]    ksyn_tslpr_il15=0;% 
         [0496]    ksyn_tslpr_tslp=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0497]    ksyn_tslpr_il21=0;% 
         [0498]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0499]    ksyn_cd127_il2_CD25=-0.011;% direction: [Xue, 2002] 
         [0500]    ksyn_cd127_il2_CD122=-0.011;% direction: [Xue, 2002] 
         [0501]    ksyn_cd127_il4 — 213=0;% 
         [0502]    ksyn_cd127_il4 — 132=0;% 
         [0503]    ksyn_cd127_il7=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0504]    ksyn_cd127_il9=0;% 
         [0505]    ksyn_cd127_il3=0;% 
         [0506]    ksyn_cd127_il5=0;% 
         [0507]    ksyn_cd127_tslp=0;% 
         [0508]    ksyn_cd127_il21=0;% 
         [0509]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0510]    ksyn_cd124_il2_CD25=0;% 
         [0511]    ksyn_cd124_il2_CD122=0;% 
         [0512]    ksyn_cd124_il4 — 213=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0513]    ksyn_cd124_il4 — 132=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0514]    ksyn_cd124_il7=0;% 
         [0515]    ksyn_cd124_il9=0;% 
         [0516]    ksyn_cd124_il3=0;% 
         [0517]    ksyn_cd124_il5=0;% 
         [0518]    ksyn_cd124_tslp=0;% 
         [0519]    ksyn_cd124_il21=0;% 
         [0520]    %%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0521]    ksyn_cd213_il2_CD25=0;% 
         [0522]    ksyn_cd213_il2_CD122=0;% 
         [0523]    ksyn_cd213_il4 — 213=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0524]    ksyn_cd213_il4 — 132=0;% 
         [0525]    ksyn_cd213_il7=0;% 
         [0526]    ksyn_cd213_il9=0;% 
         [0527]    ksyn_cd213_il3=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0528]    ksyn_cd213_il5=0;% 
         [0529]    ksyn_cd213_tslp=0;% 
         [0530]    ksyn_cd213_il21=0;% 
         [0531]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0532]    ksyn_il21r_il2_CD25=0;% 
         [0533]    ksyn_il21r_il2_CD122=0;% 
         [0534]    ksyn_il21r_il4 — 213=0;% 
         [0535]    ksyn_il21r_il4 — 132=0;% 
         [0536]    ksyn_il21r_il7=0;% 
         [0537]    ksyn_il21r_il9=0;% 
         [0538]    ksyn_il21r_il13=0;% 
         [0539]    ksyn_il21r_il15=0;% 
         [0540]    ksyn_il21r_tslp=0;% 
         [0541]    ksyn_il21r_il21=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0542]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0543]    ksyn_cd129_il2_CD25=0;% 
         [0544]    ksyn_cd129_il2_CD122=0;% 
         [0545]    ksyn_cd129_il4 — 213=0;% 
         [0546]    ksyn_cd129_il4 — 132=0;% 
         [0547]    ksyn_cd129_il7=0;% 
         [0548]    ksyn_cd129_il9=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0549]    ksyn_cd129_il13=0;% 
         [0550]    ksyn_cd129_il5=0;% 
         [0551]    ksyn_cd129_tslp=0;% 
         [0552]    ksyn_cd129_il21=0;% 
         [0553]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0554]    ksyn_il15r_il2_CD25=0;% 
         [0555]    ksyn_il15r_il2_CD122=0;% 
         [0556]    ksyn_il15r_il4 — 213=0;% 
         [0557]    ksyn_il15r_il4 — 132=0;% 
         [0558]    ksyn_il15r_il7=0;% 
         [0559]    ksyn_il15r_il9=0;% 
         [0560]    ksyn_il15r_il13=0;% 
         [0561]    ksyn_il15r_il15=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0562]    ksyn_il15r_tslp=0;% 
         [0563]    ksyn_il15r_il21=0;% 
         [0564]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0565]    ksyn_cd25_il2_CD25=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000]%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0566]    ksyn_cd25_il2_CD122=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0567]    ksyn_cd25_il4 — 213=0;% 
         [0568]    ksyn_cd25_il4 — 132=0;% 
         [0569]    ksyn_cd25_il7=0;% 
         [0570]    ksyn_cd25_il9=0;% 
         [0571]    ksyn_cd25_il13=0;% 
         [0572]    ksyn_cd25_il15=0;% 
         [0573]    ksyn_cd25_tslp=0;% 
         [0574]    ksyn_cd25_il21=0.011;% [Arai, 2010] direction, number Temp from IL-2% 
         [0575]    %%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0576]    ksyn_il13ra2_il2_CD25=0;% 
         [0577]    ksyn_il13ra2_il2_CD122=0;% 
         [0578]    ksyn_il13ra2il4 — 213=0;% 
         [0579]    ksyn_il13ra2il4 — 132=0;% 
         [0580]    ksyn_il13ra2_il7=0;% 
         [0581]    ksyn_il13ra2_il9=0;% 
         [0582]    ksyn_il13ra2_il13=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0583]    ksyn_il13ra2 — 1115=0;% 
         [0584]    ksyn_il13ra2_tslp=0;% 
         [0585]    ksyn_il13ra2_il21=0;% 
         [0586]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0587]    ksyn_cd122_il2_CD25=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0588]    ksyn_cd122_il2_CD122=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0589]    ksyn_cd122_il4 — 213=0;% 
         [0590]    ksyn_cd122_il4 — 132=0;% 
         [0591]    ksyn_cd122 — 117=0;% 
         [0592]    ksyn_cd122_il9=0;% 
         [0593]    ksyn_cd122 — 1113=0;% 
         [0594]    ksyn_cd122 — 1115=0;% 
         [0595]    ksyn_cd122_tslp=0;% 
         [0596]    ksyn_cd122_il21=0;% 
         [0597]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0598]    ksyn_cd132_il2_CD25=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0599]    ksyn_cd132_il2_CD122=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0600]    ksyn_cd132_il4 — 213=0;% 
         [0601]    ksyn_cd132_il4 — 132=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0602]    ksyn_cd132 — 117=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0603]    ksyn_cd132_il9=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0604]    ksyn_cd132_il13=0;% 
         [0605]    ksyn_cd132 — 1115=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0606]    ksyn_cd132_tslp=0;% 
         [0607]    ksyn_cd132_il21=0.011;% min ̂-1, TEMP IL-2 [Fallon, 2000] 
         [0608]    %%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0609]    kt_celltypea_cd127_tslpr=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0610]    kt_celltypea_cd124=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0611]    kt_celltypea_tslpr=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0612]    kt_celltypea_cd127=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0613]    kt_celltypea_cd124_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0614]    kt_celltypea_cd213=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0615]    kt_celltypea_cd124_cd213=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] kt_celltypea_il21r=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0616]    kt_celltypea_cd129=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0617]    kt_celltypea_il21r_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0618]    kt_celltypea_cd129_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0619]    kt_celltypea_il15r_cd122_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0620]    kt_celltypea_il15r=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0621]    kt_celltypea_cd25=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0622]    kt_celltypea_cd25_cd122_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0623]    kt_celltypea_cd25_cd122=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0624]    kt_celltypea_il15r_cd122=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0625]    kt_celltypea_il3ra2=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0626]    kt_celltypea_cd122_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0627]    kt_celltypea_cd122=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0628]    kt_celltypea_cd127_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0629]    kt_celltypea_cd132=0.007;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0630]    ke_celltypea_il9_cd129_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0631]    ke_celltypea_il21_il21r_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0632]    ke_celltypea_il13_cd124_cd213=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0633]    ke_celltypea_il4_cd124_cd213=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0634]    ke_celltypea_il4_cd124_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0635]    ke_celltypea_tslp_cd127_tslpr=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0636]    ke_celltypea_il7_cd127_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0637]    ke_celltypea_il2_cd122_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0638]    ke_celltypea_il15_il15r_cd122_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] ke_celltypea_il2_cd25_cd122_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0639]    ke_celltypea_il15_cd122_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0640]    ke_celltypea_il15_il15r_cd122=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0641]    ke_celltypea_il15_cd122=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0642]    ke_celltypea_il2_cd122=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0643]    ke_celltypea_il9_cd129=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0644]    ke_celltypea_il21_il21r=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0645]    ke_celltypea_il4_cd124=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0646]    ke_celltypea_il4_cd213=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0647]    ke_celltypea_il13_cd213=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0648]    ke_celltypea_il13_cd124=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0649]    ke_celltypea_il7_cd127=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0650]    ke_celltypea_tslp_tslpr=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0651]    ke_celltypea_il2_cd25=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0652]    %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% %%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0653]    ke_celltypea_il2_cd25_cd122=0.0;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0654]    %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% %%%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0655]    ke_celltypea_il13_il3ra2=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0656]    ke_celltypea_il2_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0657]    ke_celltypea_il15_il15r=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0658]    ke_celltypea_il15_cd132=0.04;% min ̂-1 TEMP IL-2 [Fallon, 2000] 
         [0659]    kh_celltypea_cd132=0.035;% minA-1 TEMP Fallon il-2%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0660]    kh_celltypea_il2_cd132=0.035;% minA-1 TEMP Fallon il-2% 
         [0661]    %%%%%%%%%%%%%%%%%% KEY!!! 
         [0662]    kh_celltypea_il2_cd25_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0663]    kh_celltypea_il15_il15r_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0664]    kh_celltypea_cd25_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0665]    kh_il15_il15r_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0666]    kh_il7_cd127_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0667]    kh_tslp_cd127_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0668]    kh_il4_cd124_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0669]    kh_il4_cd124_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0670]    kh_il13_cd124_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0671]    kh_celltypea_cd122_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0672]    kh_celltypea_cd122=0.035;% min ̂-1 TEMP Fallon il-2%%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0673]    kh_celltypea_cd127_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0674]    kh_celltypea_cd127=0.035;% min ̂-1 TEMP Fallon il-2 
         [0675]    kh_celltypea_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0676]    kh_celltypea_cd127_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0677]    kh_celltypea_cd124=0.035;% min ̂-1 TEMP Fallon il-2 
         [0678]    kh_celltypea_cd124_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0679]    kh_celltypea_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0680]    kh_celltypea_cd124_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0681]    kh_celltypea_il21r=0.035;% min ̂-1 TEMP Fallon il-2 
         [0682]    kh_celltypea_cd129=0.035;% min ̂-1 TEMP Fallon il-2 
         [0683]    kh_celltypea_il21r_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0684]    kh_celltypea_cd129_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0685]    kh_celltypea_il9_cd129_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0686]    kh_celltypea_il21_il21r_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0687]    kh_celltypea_il13_cd124_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0688]    kh_celltypea_il4_cd124_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0689]    kh_celltypea_il4_cd124_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0690]    kh_celltypea_il7_cd127_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0691]    kh_celltypea_tslp_cd127_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0692]    kh_celltypea_il2_cd122_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0693]    kh_celltypea_il15r_cd122_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0694]    kh_celltypea_il15r=0.035;% min ̂-1 TEMP Fallon il-2 
         [0695]    kh_celltypea_cd25=0.035;% min ̂-1 TEMP Fallon il-2%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 
         [0696]    kh_il21_il21r_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0697]    kh_il9_cd129_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0698]    kh_il2_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0699]    kh_il2_cd122_cd132=0.035;% min ̂-1 TEMP Fallon il-2 
         [0700]    kh_il2_cd25_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0701]    kh_il2_cd25=0.035;% min ̂-1 TEMP Fallon il-2 
         [0702]    kh_il15_il15r=0.035;% min ̂-1 TEMP Fallon il-2 
         [0703]    kh_il7_cd127=0.035;% min ̂-1 TEMP Fallon il-2 
         [0704]    kh_tslp_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0705]    kh_il4_cd124=0.035;% min ̂-1 TEMP Fallon il-2 
         [0706]    kh_il4_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0707]    kh_il13_cd213=0.035;% min ̂-1 TEMP Fallon il-2 
         [0708]    kh_il13_cd124=0.035;% min ̂-1 TEMP Fallon il-2 
         [0709]    kh_il21_il21r=0.035;% min ̂-1 TEMP Fallon il-2 
         [0710]    kh_il9_cd129=0.035;% min ̂-1 TEMP Fallon il-2 
         [0711]    kh_il2_cd122=0.035;% min ̂-1 TEMP Fallon il-2 
         [0712]    kh_il2_cd25_cd122=0.035;% min ̂-1 TEMP Fallon il-2 
         [0713]    kh_celltypea_il9_cd129=0.035;% minA-1 TEMP Fallon il-2 
         [0714]    kh_celltypea_il21_il21r=0.035;% minA-1 TEMP Fallon il-2 
         [0715]    kh_celltypea_il4_cd124=0.035;% minA-1 TEMP Fallon il-2 
         [0716]    kh_celltypea_il4_cd213=0.035;% minA-1 TEMP Fallon il-2 
         [0717]    kh_celltypea_il13_cd213=0.035;% minA-1 TEMP Fallon il-2 
         [0718]    kh_celltypea_il13_cd124=0.035;% minA-1 TEMP Fallon il-2 
         [0719]    kh_celltypea_il7_cd127=0.035;% min ̂-1 TEMP Fallon il-2 
         [0720]    kh_celltypea_tslp_tslpr=0.035;% min ̂-1 TEMP Fallon il-2 
         [0721]    kh_celltypea_cd25_cd122=0.035;% minA-1 TEMP Fallon il-2 
         [0722]    kh_celltypea_il2_cd25=0.035;% minA-1 TEMP Fallon il-2 
         [0723]    kh_celltypea_il2_cd25_cd122=0.035;% minA-1 TEMP Fallon il-2 
         [0724]    kh_celltypea_il2_cd122=0.035;% min ̂-1 TEMP Fallon il-2 
         [0725]    kh_celltypea_il15r_cd122=0.035;% minA-1 TEMP Fallon il-2 
         [0726]    kh_celltypea_il15_il15r_cd122=0.035;% minA-1 TEMP Fallon il-2 
         [0727]    kh_celltypea_il15_cd122_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0728]    kh_celltypea_il15_il15r=0.035;% min ̂-1 TEMP Fallon il-2 
         [0729]    kh_celltypea_il15_cd122=0.035;% min ̂-1 TEMP Fallon il-2 
         [0730]    kh_celltypea_il13_il3ra2=0.035;% min ̂-1 TEMP Fallon il-2 
         [0731]    kh_celltypea_il3ra2=0.035;% min ̂-1 TEMP Fallon il-2 
         [0732]    kh_celltypea_il15_cd132=0.035;% minA-1 TEMP Fallon il-2 
         [0733]    kx_celltypea_il15=0.15;% min ̂-1 TEMP Fallon il-2 
         [0734]    kx_celltypea_il7=0.15;% min ̂-1 TEMP Fallon il-2 
         [0735]    kx_celltypea_tslp=0.15;% min ̂-1 TEMP Fallon il-2;% 
         [0736]    kx_celltypea_il4=0.15;% min ̂-1 TEMP Fallon il-2 
         [0737]    kx_celltypea_il13=0.15;% min ̂-1 TEMP Fallon il-2 
         [0738]    kx_celltypea_il21=0.15;% min ̂-1 TEMP Fallon il-2 
         [0739]    kx_celltypea_il9=0.15;% min ̂-1 TEMP Fallon il-2 
         [0740]    kx_celltypea_il2=0.15;% min ̂-1 Fallon il-2 
         [0741]    kx_celltypea_cd25=0.15;% min ̂-1 Fallon il-2 
         [0742]    In one embodiment, the method for assessing the provided values comprises the following equations: 
         [0000]    
       
         
           
             
               
                 
                     
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             f 
                              
                             
                                 
                             
                           
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                              
                             
                               RA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                                  
                                 
                                     
                                 
                                  
                                 RA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                             
                           
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                    
                                   
                                     RA 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                        
                                       
                                         RA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                                 
                               
                                 
                                   
                                     k 
                                     f 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           R 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     k 
                                     r 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           
                                             R 
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                                 
                                   
                                     k 
                                     f 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       9 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                            
                                           R 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     k 
                                     r 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       9 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                            
                                           
                                             R 
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                                 
                                   
                                     k 
                                     t 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   V 
                                   S 
                                   
                                     
                                         
                                     
                                      
                                     
                                       CellTypeA 
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     k 
                                     syn 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             2 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   ( 
                                   
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     2 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     25 
                                                   
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     2 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       25 
                                                     
                                                     : 
                                                     
                                                       
                                                         CD 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         122 
                                                       
                                                       : 
                                                       
                                                         CD 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         132 
                                                       
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     2 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     2 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       122 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     4 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     213 
                                                   
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     4 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       124 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       213 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     4 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     132 
                                                   
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     4 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       124 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   7 
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     7 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       127 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   9 
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     9 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       129 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   13 
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     13 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       124 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       213 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     15 
                                                   
                                                   : 
                                                   
                                                     IL 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     15 
                                                      
                                                     
                                                       R 
                                                       : 
                                                       
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           122 
                                                         
                                                         : 
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           132 
                                                         
                                                       
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               syn 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                                 : 
                                                 TSLP 
                                               
                                             
                                             · 
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   TSLP 
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       127 
                                                     
                                                     : 
                                                     TSLPR 
                                                   
                                                 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             k 
                                             syn 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 21 
                                               
                                             
                                           
                                           · 
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   21 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   21 
                                                    
                                                   
                                                     R 
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                   ) 
                                 
                                 - 
                                 
                                   
                                     k 
                                     f 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                            
                                           R 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                              
                                             R 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                            
                                           R 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                              
                                             
                                               R 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                                 
                                   
                                     k 
                                     f 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                            
                                           RA 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                              
                                             RA 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     K 
                                     r 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                            
                                           RA 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                              
                                             
                                               RA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                                 
                                   
                                     
                                       k 
                                       f 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                              
                                             R 
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               21 
                                             
                                             : 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               21 
                                                
                                               R 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                    
                                   
                                       
                                     
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 2 
                                               
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 21 
                                                  
                                                 R 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   21 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   21 
                                                    
                                                   
                                                     R 
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 7 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 127 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   7 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   127 
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 7 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 127 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   7 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     127 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     132 
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 2 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   2 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 2 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   2 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     132 
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 2 
                                               
                                               : 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   25 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   2 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     25 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 2 
                                               
                                               : 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   25 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   2 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     25 
                                                   
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       122 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                               
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                                  
                                                 
                                                   R 
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                    
                                                   
                                                     R 
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       122 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                               
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                                  
                                                 
                                                   R 
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                                 : 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                    
                                                   
                                                     R 
                                                     : 
                                                     
                                                       
                                                         CD 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         122 
                                                       
                                                       : 
                                                       
                                                         CD 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         132 
                                                       
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               15 
                                                
                                               
                                                 R 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                                  
                                                 
                                                   R 
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               15 
                                                
                                               
                                                 R 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                                  
                                                 
                                                   R 
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       122 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   122 
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 15 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     122 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     132 
                                                   
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       - 
                                       
                                         
                                           k 
                                           f 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               15 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             L 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               15 
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                       + 
                                       
                                         
                                           k 
                                           r 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               15 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             C 
                                             S 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   15 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                       
                     
                   
                 
               
               
                 1 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             127 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             127 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                            
                           
                             RA 
                              
                             
                                 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                                
                               RA 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           
                             i 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                            
                           
                             RA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                                
                               
                                 RA 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           IL 
                            
                           
                               
                           
                            
                           9 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           9 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                                
                               RA 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                           
                       
                        
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                                  
                                 
                                   RA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 2 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTtypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 3 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 4 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                            
                           
                             RA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               RA 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                            
                           
                             RA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 RA 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         
                           t 
                            
                           
                               
                           
                         
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 RA 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 RA 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 Il 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 15 
                                  
                                 RA 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           
                             S 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   RA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 5 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             fe 
                              
                             
                                 
                             
                           
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               RA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 RA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               RA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   RA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             fe 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             
                               S 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   RA 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                       
                                   
                                    
                                   RA 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CelltypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   Il 
                                    
                                   
                                       
                                   
                                    
                                   14 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   RA 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     RA 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   6 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           s 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           25 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             25 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               122 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           7 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                            
                                           
                                             R 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       TSLP 
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   syn 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                     
                                 
                                  
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           s 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             s 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   7 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CelltypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   8 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   9 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           
                             k 
                             t 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                           · 
                           
                             
                               R 
                               
                                 S 
                                  
                                 
                                     
                                 
                               
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                         
                          
                         k 
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   10 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CelltypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             127 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     
                                       
                                         
                                           
                                             
                                               
                                                 
                                                   
                                                     
                                                       
                                                         
                                                           
                                                             k 
                                                             syn 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             127 
                                                             
                                                             : 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             2 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             25 
                                                             
                                                             
                                                             
                                                           
                                                           · 
                                                           
                                                             C 
                                                             S 
                                                             
                                                             CellTypeA 
                                                             : 
                                                             
                                                             IL 
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             2 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             25 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             122 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             132 
                                                             
                                                             
                                                             
                                                             
                                                             
                                                             
                                                           
                                                         
                                                         + 
                                                       
                                                     
                                                   
                                                   
                                                     
                                                       
                                                         
                                                           
                                                             k 
                                                             syn 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             127 
                                                             
                                                             : 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             2 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             122 
                                                             
                                                             
                                                             
                                                           
                                                           · 
                                                           
                                                             C 
                                                             S 
                                                             
                                                             CellTypeA 
                                                             : 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             2 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             122 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             132 
                                                             
                                                             
                                                             
                                                             
                                                           
                                                         
                                                         + 
                                                       
                                                     
                                                   
                                                 
                                               
                                             
                                             
                                               
                                                 
                                                   
                                                     
                                                       k 
                                                       syn 
                                                       
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           127 
                                                         
                                                         : 
                                                         
                                                           
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             4 
                                                           
                                                           : 
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                           
                                                         
                                                       
                                                     
                                                     · 
                                                     
                                                       C 
                                                       S 
                                                       
                                                         CellTypeA 
                                                         : 
                                                         
                                                           
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             4 
                                                           
                                                           : 
                                                           
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                             
                                                           
                                                         
                                                       
                                                     
                                                   
                                                   + 
                                                 
                                               
                                             
                                           
                                         
                                       
                                       
                                         
                                           
                                             
                                               
                                                 k 
                                                 syn 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     127 
                                                   
                                                   : 
                                                   
                                                     
                                                       IL 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       4 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                               · 
                                               
                                                 C 
                                                 
                                                   S 
                                                    
                                                   
                                                       
                                                   
                                                 
                                                 
                                                   CellTypeA 
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       124 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       132 
                                                     
                                                   
                                                 
                                               
                                             
                                             + 
                                           
                                         
                                       
                                     
                                   
                                 
                                 
                                   
                                     
                                       
                                         
                                           k 
                                           syn 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               127 
                                             
                                             : 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               7 
                                             
                                           
                                         
                                         · 
                                         
                                           C 
                                           
                                             S 
                                              
                                             
                                                 
                                             
                                           
                                           
                                             CellTypeA 
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 7 
                                               
                                               : 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   127 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                               
                                             
                                           
                                         
                                       
                                       + 
                                     
                                   
                                 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                            
                                           
                                             R 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       TSLP 
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLP 
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   syn 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   TSLP 
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   11 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSPLR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   TSLP 
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   12 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             TSLPR 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           TSLPR 
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           25 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTyeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             2 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               25 
                                             
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           7 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                            
                                           
                                             R 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       TSLPR 
                                       : 
                                       TSLP 
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   syn 
                                   
                                     TSLPR 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             L 
                             TSLP 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   13 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             TSLPR 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             h 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLP 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   14 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CelTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             TSLP 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   15 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLP 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLPR 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   16 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           25 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             25 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               122 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           7 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                            
                                           
                                             R 
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       TSLP 
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   syn 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               S 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     13 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                               
                                
                               
                                   
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   17 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             fe 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CelltypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   18 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                                
                               
                                   
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   19 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   20 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       V 
                       S 
                       
                         CellTypeA 
                         : 
                         
                           CD 
                            
                           
                               
                           
                            
                           213 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     129 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               TSLP 
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                       
                       ) 
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           s 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 21 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 22 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         s 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           s 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 23 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               Cd 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 24 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           f 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                     
                     + 
                     
                       V 
                       S 
                       
                         CellTypeA 
                         : 
                         
                           CD 
                            
                           
                               
                           
                            
                           213 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     129 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 TSLP 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                       
                       ) 
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 25 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           fe 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 26 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       V 
                       S 
                       
                         CellTypeA 
                         : 
                         
                           CD 
                            
                           
                               
                           
                            
                           129 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     129 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               TSLP 
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             syn 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                             
                           
                           · 
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                       
                       ) 
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 27 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         - 
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 28 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 29 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                            
                           
                             R 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 30 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 31 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             
                               CellTypeACD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 32 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           9 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   Cd 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   Cd 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 33 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 Il 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     129 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 34 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 35 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                     
                                 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 36 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           13 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               ellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 37 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                                
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 38 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 39 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 40 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 41 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 42 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           TSLP 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         TSLP 
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           TSLP 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             D 
                              
                             
                                 
                             
                              
                             127 
                           
                           : 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 43 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             TSLP 
                             : 
                             
                               
                                 D 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           TSLP 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           TSLP 
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           TSLP 
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             127 
                           
                           : 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 TSLPR 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 44 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           7 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 45 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                 : 
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 46 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           2 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 47 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellType 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                        
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 48 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                            
                           
                             R 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             R 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 49 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 CD122 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                            
                           
                             R 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         R 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             R 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           IL 
                            
                           
                               
                           
                            
                           15 
                            
                           
                             R 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                                 
                             
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                     
                                 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         t 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 50 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                         
                       
                         
                           
                             - 
                             
                               k 
                               f 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                           · 
                           
                             
                               R 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           · 
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         + 
                         
                           
                             k 
                             r 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                           · 
                           
                             
                               R 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                         
                         - 
                         
                           
                             k 
                             t 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                           · 
                           
                             
                               R 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                         
                         + 
                         
                           V 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         + 
                         
                           ( 
                           
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       7 
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       7 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       9 
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       9 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         129 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       
                                         R 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     TSLP 
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     TSLP 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       TSLPR 
                                     
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 syn 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                               
                               · 
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                           ) 
                         
                         - 
                         
                           
                             k 
                             f 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                           · 
                           
                             
                               R 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           · 
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                         + 
                         
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       R 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                             
                         
                       
                     
                   
                 
                 
                   51 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellType 
                                
                               
                                   
                               
                                
                               
                                 A 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   52 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                    
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   9 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     9 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       129 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     13 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     
                                       R 
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 TSLP 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 CellTypeA 
                                 : 
                                 
                                   TSLP 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                     : 
                                     TSLPR 
                                   
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               syn 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                 
                               
                             
                             · 
                             
                               C 
                               S 
                               
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                        
                                       
                                         R 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                     
                                 
                               
                             
                           
                         
                         ) 
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   53 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               CD 
                               : 
                               
                                 25 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   54 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   55 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   56 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   57 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                       
                                   
                                    
                                   R 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   58 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   59 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   60 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   f 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       
                                         R 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       
                                         R 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     
                                       R 
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                          
                                         
                                           R 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               122 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 f 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     R 
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       R 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     R 
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                          
                                         R 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 x 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                 
                               
                               · 
                               
                                 V 
                                 e 
                               
                               · 
                               
                                 N 
                                 A 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           
                             
                               Y 
                               CellTypeA 
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           
                             N 
                             A 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           repeat_above 
                            
                           _for 
                            
                           _additional 
                            
                           _cell 
                            
                           _types 
                         
                         ) 
                       
                     
                   
                 
                 
                   61 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   fe 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       
                                         R 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       
                                         R 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     
                                       R 
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                          
                                         
                                           R 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               122 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 fe 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     R 
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       15 
                                        
                                       R 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                   
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     15 
                                      
                                     R 
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                       : 
                                       
                                           
                                       
                                        
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                          
                                         R 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           1 
                           
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           x 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                       
                     
                   
                 
                 
                   62 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   63 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   f 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       7 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           127 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 f 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 x 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                 
                               
                               · 
                               
                                 V 
                                 e 
                               
                               · 
                               
                                 N 
                                 A 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           
                             
                               Y 
                               CellTypeA 
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           
                             N 
                             A 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           repeat_above 
                            
                           _for 
                            
                           _additional 
                            
                           _cell 
                            
                           _types 
                         
                         ) 
                       
                     
                   
                 
                 
                   64 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   fe 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       7 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           127 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 fe 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       127 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     7 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         127 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           1 
                           
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           x 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                         
                       
                     
                   
                 
                 
                   65 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               
                                 C 
                                  
                                 
                                     
                                 
                                  
                                 D 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   66 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           TSLP 
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 
                                   
                                     
                                       - 
                                       
                                         k 
                                         f 
                                         
                                           TSLP 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               127 
                                             
                                             : 
                                             TSLPR 
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               127 
                                             
                                             : 
                                             TSLPR 
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       TSLP 
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       r 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             TSLP 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 127 
                                               
                                               : 
                                               TSLPR 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                   
                                   - 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       f 
                                       
                                         TSLP 
                                         : 
                                         TSLPR 
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           TSLPR 
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       TSLP 
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       
                                         
                                           
                                             k 
                                             r 
                                             
                                               TSLP 
                                               : 
                                               TSLPR 
                                             
                                           
                                           · 
                                           
                                             
                                               C 
                                               S 
                                               
                                                 CellTypeA 
                                                 : 
                                                 
                                                   TSLP 
                                                   : 
                                                   TSLPR 
                                                 
                                               
                                             
                                              
                                             
                                               [ 
                                               t 
                                               ] 
                                             
                                           
                                         
                                         + 
                                         
                                           
                                             k 
                                             x 
                                             
                                               CellTypeA 
                                               : 
                                               TSLP 
                                             
                                           
                                           · 
                                         
                                       
                                     
                                   
                                   
                                     
                                       
                                         
                                           L 
                                           i 
                                           
                                             CellType 
                                             : 
                                             TSLP 
                                           
                                         
                                         · 
                                         
                                           V 
                                           e 
                                         
                                         · 
                                         
                                           N 
                                           A 
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           
                             
                               Y 
                               CellTypeA 
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           
                             N 
                             A 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           repeat_above 
                            
                           _for 
                            
                           _additional 
                            
                           _cell 
                            
                           _types 
                         
                         ) 
                       
                     
                   
                 
                 
                   67 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             TSLP 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 
                                   
                                     
                                       - 
                                       
                                         k 
                                         fe 
                                         
                                           TSLP 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               127 
                                             
                                             : 
                                             TSLPR 
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               127 
                                             
                                             : 
                                             TSLPR 
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         TSLP 
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       re 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         i 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             TSLP 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 127 
                                               
                                               : 
                                               TSLPR 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                   
                                   - 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       fe 
                                       
                                         TSLP 
                                         : 
                                         TSLPR 
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         i 
                                         
                                           CellTypeA 
                                           : 
                                           TSLPR 
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         TSLP 
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       TSLP 
                                       : 
                                       TSLPR 
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           TSLP 
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           1 
                           
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           x 
                           
                             CellTypeA 
                             : 
                             TSLP 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             TSLP 
                           
                         
                       
                     
                   
                 
                 
                   68 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             TSLP 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             TSLP 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   69 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       ( 
                       
                         
                           
                             
                               
                                 
                                   
                                     
                                       
                                         
                                           
                                             
                                               
                                                 
                                                   
                                                     - 
                                                     
                                                       k 
                                                       f 
                                                       
                                                         
                                                           IL 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           4 
                                                         
                                                         : 
                                                         
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                           
                                                           : 
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             132 
                                                           
                                                         
                                                       
                                                     
                                                   
                                                   · 
                                                   
                                                     
                                                       R 
                                                       S 
                                                       
                                                         CellTypeA 
                                                         : 
                                                         
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                           
                                                           : 
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             132 
                                                           
                                                         
                                                       
                                                     
                                                      
                                                     
                                                       [ 
                                                       t 
                                                       ] 
                                                     
                                                   
                                                   · 
                                                   
                                                     L 
                                                     
                                                       IL 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       4 
                                                     
                                                   
                                                 
                                                 + 
                                               
                                             
                                           
                                           
                                             
                                               
                                                 
                                                   
                                                     k 
                                                     r 
                                                     
                                                       
                                                         IL 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         4 
                                                       
                                                       : 
                                                       
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           124 
                                                         
                                                         : 
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           132 
                                                         
                                                       
                                                     
                                                   
                                                   · 
                                                   
                                                     
                                                       C 
                                                       S 
                                                       
                                                         CellTypeA 
                                                         : 
                                                         
                                                           
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             4 
                                                           
                                                           : 
                                                           
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             132 
                                                             
                                                           
                                                         
                                                       
                                                     
                                                      
                                                     
                                                       [ 
                                                       t 
                                                       ] 
                                                     
                                                   
                                                 
                                                 - 
                                               
                                             
                                           
                                         
                                       
                                     
                                     
                                       
                                         
                                           
                                             
                                               k 
                                               f 
                                               
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   4 
                                                 
                                                 : 
                                                 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     124 
                                                   
                                                   : 
                                                   
                                                     CD 
                                                      
                                                     
                                                         
                                                     
                                                      
                                                     213 
                                                   
                                                 
                                               
                                             
                                             · 
                                             
                                               
                                                 R 
                                                 S 
                                                 
                                                   CellTypeA 
                                                   : 
                                                   
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       214 
                                                     
                                                     : 
                                                     
                                                       CD 
                                                        
                                                       
                                                           
                                                       
                                                        
                                                       213 
                                                     
                                                   
                                                 
                                               
                                                
                                               
                                                 [ 
                                                 t 
                                                 ] 
                                               
                                             
                                             · 
                                             
                                               L 
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 4 
                                               
                                             
                                           
                                           + 
                                         
                                       
                                     
                                   
                                 
                               
                               
                                 
                                   
                                     
                                       
                                         k 
                                         r 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               124 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                       · 
                                       
                                         
                                           C 
                                           S 
                                           
                                             CellTypeA 
                                             : 
                                             
                                               
                                                 IL 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 4 
                                               
                                               : 
                                               
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   124 
                                                 
                                                 : 
                                                 
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   132 
                                                 
                                               
                                             
                                           
                                         
                                          
                                         
                                           [ 
                                           t 
                                           ] 
                                         
                                       
                                     
                                     - 
                                   
                                 
                               
                             
                           
                         
                         
                           
                             
                               
                                 
                                   k 
                                   f 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     R 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                    
                                   
                                     [ 
                                     t 
                                     ] 
                                   
                                 
                                 · 
                                 
                                   L 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                 
                               
                               + 
                               
                                 
                                   k 
                                   r 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       124 
                                     
                                   
                                 
                                 · 
                               
                             
                           
                         
                         
                           
                             
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               - 
                             
                           
                         
                         
                           
                             
                               
                                 
                                   k 
                                   f 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     R 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                    
                                   
                                     [ 
                                     t 
                                     ] 
                                   
                                 
                                 · 
                                 
                                   L 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     4 
                                   
                                 
                               
                               + 
                               
                                 
                                   k 
                                   r 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                                 · 
                               
                             
                           
                         
                         
                           
                             
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               + 
                               
                                 
                                   k 
                                   x 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                   
                                 
                                 · 
                                 
                                   L 
                                   x 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                   
                                 
                                 · 
                               
                             
                           
                         
                         
                           
                             
                               
                                 V 
                                 e 
                               
                               · 
                               
                                 N 
                                 A 
                               
                             
                           
                         
                       
                       ) 
                     
                     · 
                     
                       
                         
                           Y 
                           CellTypeA 
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       
                         N 
                         A 
                       
                     
                   
                 
               
               
                 70 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     - 
                                     
                                       k 
                                       fe 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               124 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     fe 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               124 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               213 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     fe 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         4 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             4 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             123 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   re 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       4 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     C 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                    
                                   
                                     [ 
                                     t 
                                     ] 
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         1 
                         
                           
                             V 
                             e 
                           
                            
                           
                             N 
                             A 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         x 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                   
                 
               
               
                 71 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   4 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   72 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           13 
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     - 
                                     
                                       k 
                                       f 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               124 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               213 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     f 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           124 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         124 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     f 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         213 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     f 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                            
                                           Ra 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                              
                                             Ra 
                                              
                                             
                                                 
                                             
                                              
                                             2 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   x 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 · 
                                 
                                   L 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                   
                                 
                                 · 
                                 
                                   V 
                                   e 
                                 
                                 · 
                                 
                                   N 
                                   A 
                                 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         
                           
                             Y 
                             CellTypeA 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         
                           N 
                           A 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         repeat_above 
                          
                         _for 
                          
                         _additional 
                          
                         _cell 
                          
                         _types 
                       
                       ) 
                     
                   
                 
               
               
                 73 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     
                                       
                                         
                                           
                                             
                                               
                                                 
                                                   
                                                     
                                                       
                                                         
                                                           
                                                             - 
                                                             
                                                             k 
                                                             fe 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             13 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                             
                                                             
                                                             
                                                             
                                                           
                                                           · 
                                                           
                                                             
                                                             R 
                                                             i 
                                                             
                                                             CellTypeA 
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                             
                                                             
                                                             
                                                             
                                                              
                                                             
                                                             [ 
                                                             t 
                                                             ] 
                                                             
                                                           
                                                           · 
                                                           
                                                             L 
                                                             i 
                                                             
                                                             CellTypeA 
                                                             : 
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             13 
                                                             
                                                             
                                                           
                                                         
                                                         + 
                                                       
                                                     
                                                   
                                                   
                                                     
                                                       
                                                         
                                                           
                                                             k 
                                                             re 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             13 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                             
                                                             
                                                             
                                                           
                                                           · 
                                                           
                                                             
                                                             C 
                                                             
                                                             i 
                                                              
                                                             
                                                               
                                                             
                                                             
                                                             
                                                             CellTypeA 
                                                             : 
                                                             
                                                             
                                                             IL 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             13 
                                                             
                                                             : 
                                                             
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                             
                                                             : 
                                                             
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             213 
                                                             
                                                             
                                                             
                                                             
                                                             
                                                              
                                                             
                                                             [ 
                                                             t 
                                                             ] 
                                                             
                                                           
                                                         
                                                         - 
                                                       
                                                     
                                                   
                                                 
                                               
                                             
                                             
                                               
                                                 
                                                   
                                                     
                                                       k 
                                                       fe 
                                                       
                                                         
                                                           IL 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           13 
                                                         
                                                         : 
                                                         
                                                           CD 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           124 
                                                         
                                                       
                                                     
                                                     · 
                                                     
                                                       
                                                         R 
                                                         i 
                                                         
                                                           CellTypeA 
                                                           : 
                                                           
                                                             CD 
                                                              
                                                             
                                                               
                                                             
                                                              
                                                             124 
                                                           
                                                         
                                                       
                                                        
                                                       
                                                         [ 
                                                         t 
                                                         ] 
                                                       
                                                     
                                                     · 
                                                     
                                                       L 
                                                       i 
                                                       
                                                         CellTypeA 
                                                         : 
                                                         
                                                           IL 
                                                            
                                                           
                                                               
                                                           
                                                            
                                                           13 
                                                         
                                                       
                                                     
                                                   
                                                   + 
                                                 
                                               
                                             
                                           
                                         
                                       
                                       
                                         
                                           
                                             
                                               
                                                 k 
                                                 e 
                                                 
                                                   IL 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   13 
                                                    
                                                   CD 
                                                    
                                                   
                                                       
                                                   
                                                    
                                                   124 
                                                 
                                               
                                               · 
                                               
                                                 
                                                   C 
                                                   i 
                                                   
                                                     CellTypeA 
                                                     : 
                                                     
                                                       
                                                         IL 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         13 
                                                       
                                                       : 
                                                       
                                                         CD 
                                                          
                                                         
                                                             
                                                         
                                                          
                                                         124 
                                                       
                                                     
                                                   
                                                 
                                                  
                                                 
                                                   [ 
                                                   t 
                                                   ] 
                                                 
                                               
                                             
                                             - 
                                           
                                         
                                       
                                     
                                   
                                 
                                 
                                   
                                     
                                       
                                         
                                           k 
                                           fe 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               13 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               213 
                                             
                                           
                                         
                                         · 
                                         
                                           
                                             R 
                                             i 
                                             
                                               CellTypeA 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 213 
                                               
                                             
                                           
                                            
                                           
                                             [ 
                                             t 
                                             ] 
                                           
                                         
                                         · 
                                         
                                           L 
                                           i 
                                           
                                             CellTypeA 
                                             : 
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               13 
                                             
                                           
                                         
                                       
                                       - 
                                     
                                   
                                 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     fe 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                            
                                           Ra 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     
                                       re 
                                        
                                       
                                           
                                       
                                     
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             13 
                                              
                                             Ra 
                                              
                                             
                                                 
                                             
                                              
                                             2 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   re 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       213 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     C 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                    
                                   
                                     [ 
                                     t 
                                     ] 
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         1 
                         
                           
                             V 
                             e 
                           
                           · 
                           
                             N 
                             
                               A 
                                
                               
                                   
                               
                             
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         x 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                     
                   
                 
               
               
                 74 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                    
                                   Ra 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   75 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     - 
                                     
                                       k 
                                       f 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           
                                             R 
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                            
                                           
                                             R 
                                              
                                             
                                                 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                              
                                             
                                               R 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     
                                       f 
                                        
                                       
                                           
                                       
                                     
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         R 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           R 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     r 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         R 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       S 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                              
                                             R 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 + 
                                 
                                   
                                     k 
                                     x 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                     
                                   
                                   · 
                                 
                               
                             
                           
                           
                             
                               
                                 
                                   L 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                   V 
                                   e 
                                 
                                 · 
                                 
                                   N 
                                   A 
                                 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         
                           
                             T 
                             CellTypeA 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         
                           N 
                           A 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         repeat_above 
                          
                         _for 
                          
                         _additional 
                          
                         _cell 
                          
                         _types 
                       
                       ) 
                     
                   
                 
               
               
                 76 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     - 
                                     
                                       k 
                                       fe 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           
                                             R 
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             2 
                                           
                                           : 
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             21 
                                              
                                             
                                               R 
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                                 - 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     fe 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         R 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       R 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           R 
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   re 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                        
                                       R 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     C 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           21 
                                            
                                           R 
                                         
                                       
                                     
                                   
                                    
                                   
                                     [ 
                                     t 
                                     ] 
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         1 
                         
                           
                             V 
                             e 
                           
                           · 
                           
                             N 
                             A 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         x 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                       
                     
                   
                 
               
               
                 77 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   22 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   21 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   78 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 
                                   
                                     
                                       - 
                                       
                                         k 
                                         f 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               129 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               129 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       r 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               9 
                                             
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 129 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                   
                                   - 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       f 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           129 
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         S 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       r 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           129 
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         S 
                                         
                                           CelTypeA 
                                           : 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               9 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               129 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     k 
                                     x 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     L 
                                     i 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     V 
                                     e 
                                   
                                   · 
                                   
                                     N 
                                     A 
                                   
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           
                             
                               Y 
                               CellTypeA 
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           
                             N 
                             A 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           repeat_above 
                            
                           _for 
                            
                           _additional 
                            
                           _cell 
                            
                           _types 
                         
                         ) 
                       
                     
                   
                 
                 
                   79 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 
                                   
                                     
                                       - 
                                       
                                         k 
                                         fe 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               129 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         i 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               129 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       re 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         C 
                                         i 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             
                                               IL 
                                                
                                               
                                                   
                                               
                                                
                                               9 
                                             
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 129 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                   
                                   - 
                                 
                               
                             
                             
                               
                                 
                                   
                                     
                                       k 
                                       fe 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           129 
                                         
                                       
                                     
                                     · 
                                     
                                       
                                         R 
                                         i 
                                         
                                           CellTypeA 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                         
                                       
                                        
                                       
                                         [ 
                                         t 
                                         ] 
                                       
                                     
                                     · 
                                     
                                       L 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                       
                                     
                                   
                                   + 
                                 
                               
                             
                             
                               
                                 
                                   
                                     k 
                                     re 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         129 
                                       
                                     
                                   
                                   · 
                                   
                                     
                                       C 
                                       i 
                                       
                                         CellTypeA 
                                         : 
                                         
                                           
                                             IL 
                                              
                                             
                                                 
                                             
                                              
                                             9 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                         
                                       
                                     
                                      
                                     
                                       [ 
                                       t 
                                       ] 
                                     
                                   
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           1 
                           
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           x 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                           
                         
                       
                     
                   
                 
                 
                   80 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         d 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 81 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           2 
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
 
                   
                    
                   
                     
                       
                         ( 
                         
                           
                             
                               - 
                               
                                 k 
                                 f 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               f 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                           + 
                           
                             
                               k 
                               r 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 S 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           + 
                           
                             
                               k 
                               x 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                             · 
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                         ) 
                       
                       · 
                       
                         
                           
                             Y 
                             CellTypeA 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         
                           N 
                           A 
                         
                       
                     
                     + 
                     
                       ( 
                       
                         repeat_above 
                          
                         _for 
                          
                         _additional 
                          
                         _cell 
                          
                         _types 
                       
                       ) 
                     
                   
                 
               
               
                 82 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         ( 
                         
                           
                             
                               - 
                               
                                 k 
                                 fe 
                                 
                                   
                                     IL 
                                      
                                     
                                         
                                     
                                      
                                     2 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               fe 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               fe 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                       : 
                                       
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               fe 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               fe 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       25 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         25 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                           - 
                           
                             
                               k 
                               fe 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                             · 
                             
                               
                                 R 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                             · 
                             
                               L 
                               i 
                               
                                 CellTypeA 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                           + 
                           
                             
                               k 
                               re 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                             · 
                             
                               
                                 C 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                                
                               
                                 [ 
                                 t 
                                 ] 
                               
                             
                           
                         
                         ) 
                       
                       · 
                       
                         1 
                         
                           
                             V 
                             e 
                           
                           · 
                           
                             N 
                             A 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         x 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                     
                   
                 
               
               
                 83 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         L 
                         d 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             25 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         h 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             2 
                           
                           : 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 84 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         Y 
                         CellTypeA 
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     factors_affecting 
                      
                     _cell 
                      
                     _proliferation 
                   
                 
               
               
                 85 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           9 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 86 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             9 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             129 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   129 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               9 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               129 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 9 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 129 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 87 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           21 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 88 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             21 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               21 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 21 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 89 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 90 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             132 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 91 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           4 
                         
                       
                     
                     - 
                     
                       
                         l 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 92 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             4 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             1124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               C 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               4 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 4 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 93 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         
                           IL 
                            
                           
                               
                           
                            
                           13 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         r 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 94 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         fe 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         L 
                         i 
                         
                           CellTypeA 
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                     
                     - 
                     
                       
                         k 
                         re 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                           : 
                           
                             CD 
                              
                             
                                 
                             
                              
                             213 
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         fe 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         re 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             124 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   213 
                                 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         h 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 95 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             13 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   214 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   96 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                       
                       
                         
                            
                           t 
                         
                          
                         
                             
                         
                       
                     
                     = 
                     
                       
                         
                           k 
                           
                             fe 
                              
                             
                                 
                             
                           
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               124 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 213 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               213 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     124 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     213 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 124 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   124 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   97 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           
                             S 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           
                             k 
                             S 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             7 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   98 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               7 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 7 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   7 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   127 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   99 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           TSLP 
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   100 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TSLPR 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             TSLP 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             TSLP 
                             : 
                             TSLPR 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                   
                               
                                
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 127 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               127 
                             
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     127 
                                   
                                   : 
                                   TSLPR 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               TSLP 
                               : 
                               TSLPR 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 TSLP 
                                 : 
                                 TSLPR 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   101 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   102 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               i 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             h 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   103 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   104 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CelltypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               C 
                                
                               
                                   
                               
                                
                               D 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   105 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   24 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   106 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CelltypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               i 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   25 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   107 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CelltypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   108 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           
                             fe 
                              
                             
                                 
                             
                           
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               2 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             re 
                              
                             
                                 
                             
                           
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 25 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               25 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     25 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           
                             k 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   109 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             
                               S 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   110 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                   
                               
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                   
                               
                                
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             
                               i 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                     
                                 
                                  
                                 
                                   R 
                                   : 
                                   
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       132 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                   
                               
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                       
                                   
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   111 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
             
               
                 
                   
                     
                        
                       
                         C 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                     
                     
                        
                       t 
                     
                   
                   = 
                   
                     
                       
                         k 
                         f 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           L 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         r 
                         
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                           
                           : 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             R 
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                     
                                 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTtypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     + 
                     
                       
                         k 
                         f 
                         
                           
                             CD 
                              
                             
                                 
                             
                              
                             122 
                           
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 1 
                                  
                                 
                                     
                                 
                                  
                                 5 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 RCD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                     - 
                     
                       
                         k 
                         e 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                       
                       · 
                       
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                     
                   
                 
               
               
                 112 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               R 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           
                             e 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   113 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           
                             r 
                              
                             
                                 
                             
                           
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   114 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                                
                               
                                   
                               
                                
                               
                                 R 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   R 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 
                                   R 
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   115 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           
                             S 
                              
                             
                                 
                             
                           
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               S 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   116 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               CD 
                                
                               
                                   
                               
                                
                               122 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             
                               i 
                                
                               
                                   
                               
                             
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       CD 
                                        
                                       
                                           
                                       
                                        
                                       122 
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   117 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             IL 
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           f 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   118 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               15 
                             
                             : 
                             
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           fe 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 132 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             
                               CD 
                                
                               
                                   
                               
                                
                               132 
                             
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 CD 
                                  
                                 
                                     
                                 
                                  
                                 122 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                                  
                                 R 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             IL 
                              
                             
                                 
                             
                              
                             15 
                              
                             
                               R 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                    
                                   
                                     R 
                                     : 
                                     
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         122 
                                       
                                       : 
                                       
                                         CD 
                                          
                                         
                                             
                                         
                                          
                                         132 
                                       
                                     
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 15 
                               
                               : 
                               
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   122 
                                 
                                 : 
                                 
                                   CD 
                                    
                                   
                                       
                                   
                                    
                                   132 
                                 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   15 
                                 
                                 : 
                                 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     122 
                                   
                                   : 
                                   
                                     CD 
                                      
                                     
                                         
                                     
                                      
                                     132 
                                   
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   119 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                                  
                                 Ra 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                                  
                                 
                                     
                                 
                                  
                                 R 
                                  
                                 
                                     
                                 
                                  
                                 a 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                    
                                   Ra 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               R 
                                
                               
                                   
                               
                                
                               a 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                                  
                                 R 
                                  
                                 
                                     
                                 
                                  
                                 a 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                       
                       + 
                       
                         ( 
                         
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           25 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             25 
                                           
                                           : 
                                           
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               122 
                                             
                                             : 
                                             
                                               CD 
                                                
                                               
                                                   
                                               
                                                
                                               132 
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           122 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           2 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             122 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           213 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           CD 
                                            
                                           
                                               
                                           
                                            
                                           132 
                                         
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     
                                       S 
                                        
                                       
                                           
                                       
                                     
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           4 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         7 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           7 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         9 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           9 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             129 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           13 
                                         
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             124 
                                           
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             213 
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         15 
                                       
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                         
                                         : 
                                         
                                           IL 
                                            
                                           
                                               
                                           
                                            
                                           15 
                                            
                                           
                                             R 
                                             : 
                                             
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 122 
                                               
                                               : 
                                               
                                                 CD 
                                                  
                                                 
                                                     
                                                 
                                                  
                                                 132 
                                               
                                             
                                           
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   
                                     k 
                                     syn 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         13 
                                          
                                         Ra 
                                          
                                         
                                             
                                         
                                          
                                         2 
                                       
                                       : 
                                       TSLP 
                                     
                                   
                                   · 
                                   
                                     C 
                                     S 
                                     
                                       CellTypeA 
                                       : 
                                       
                                         TSLP 
                                         : 
                                         
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             127 
                                           
                                           : 
                                           TSLPR 
                                         
                                       
                                     
                                   
                                 
                                 + 
                               
                             
                           
                           
                             
                               
                                 
                                   k 
                                   syn 
                                   
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       13 
                                        
                                       Ra 
                                        
                                       
                                           
                                       
                                        
                                       2 
                                     
                                     : 
                                     
                                       IL 
                                        
                                       
                                           
                                       
                                        
                                       21 
                                     
                                   
                                 
                                 · 
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                       
                                       : 
                                       
                                         IL 
                                          
                                         
                                             
                                         
                                          
                                         21 
                                          
                                         
                                           R 
                                           : 
                                           
                                             CD 
                                              
                                             
                                                 
                                             
                                              
                                             132 
                                           
                                         
                                       
                                     
                                   
                                 
                               
                             
                           
                         
                         ) 
                       
                     
                   
                 
                 
                   120 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                                  
                                 Ra 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                                  
                                 Ra 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 IL 
                                  
                                 
                                     
                                 
                                  
                                 13 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                             
                             : 
                             
                               IL 
                                
                               
                                   
                               
                                
                               13 
                                
                               Ra 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                 
                                 : 
                                 
                                   IL 
                                    
                                   
                                       
                                   
                                    
                                   13 
                                    
                                   Ra 
                                    
                                   
                                       
                                   
                                    
                                   2 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
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         [0743]    Using our model, we determine the extent of signaling on various cytokine receptor types and examine the likelihood that each will reach a given threshold, based on the initial values provided above. 
         [0744]    The models enable us to address many unanswered questions. Relevant to the question of response to anti-CD25, we can quantitatively investigate whether blocking CD25 leads to the availability of more CD 132 for signaling from complexes between IL-7 and the IL-7 receptor. 
         [0745]    In one embodiment, the model is utilized to predict the effect of an anti-CD25 therapy on a subject prior to treatment. A first set of input values is provided, and the model is utilized to analyze the level of cytokine signaling prior to treatment. Then, a second set of input values is utilized in which the number of available CD25 receptors is reduced to reflect the therapy&#39;s effect, and the model is utilized to determine the level of signaling on various cytokine receptors after the administration of the therapy. In one embodiment, if IL-7 signaling increases significantly, then it is predicted that CD56bright NK cells will expand and the subject will respond to the therapy. 
         [0746]    For example, the modeling shows that for a subject represented by a certain set of input values, the quantity of cytokine will be the limiting factor in cytokine signaling.  FIG. 2(   a ) shows an initial example, with concentrations of IL-2, IL-7, and IL-21 set to 0.1 nM each. In this case, the signaling plateaus occur when each cytokine runs out. When we provide a second set of values in which the amount of CD25 has been reduced to reflect the expected effect of the therapy, as shown in  FIG. 2(   b ), there is little effect on the level of IL-7 or IL-21 signaling, because the concentration of cytokine and not the receptor levels remain the limiting factor. In one specific embodiment, this subject would be predicted to be a non-responder to anti-CD25. 
         [0747]    In contrast,  FIG. 3(   a ) shows the out put of the model for a different set of input values representing a different patient, in which the concentrations of IL-2, IL-7, and IL-21 are significantly higher at 10 nM each. In this case, when a second set of input values is provided with the levels of CD25 reduced to reflect the effect of an anti-CD25 therapy, as shown in  FIG. 3(   b ), the level of IL-2 signaling drops as expected and the level of IL-7 signaling increases significantly. In one specific embodiment, this patient would be predicted to respond to an anti-CD25 therapy. 
       Example 2 
     Predicting the Effects of a BAFF Antagonist on a Subject Prior to Treatment 
       [0748]    In one embodiment, the therapy is a BAFF antagonist. The therapy&#39;s target receptor subunits are BAFF-R, APRIL, and TACI. The ligands that interacts with the therapy&#39;s target receptor subunits are BAFF and APRIL. The receptor subunits that interact with the therapy&#39;s target receptor subunits are none. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are none. The receptor subunits that interact with receptor subunits and ligands that bind to receptor subunits that interact with receptor subunits are none. A receptor subunit that binds to a ligand is HSPG. 
       Methods and Methods 
       [0749]    In one embodiment, assaying a sample further comprises utilizing the following protocol adapted from [Cesana, 2006], [Venken, 2008], [Hatjiharissi, 2007] 
         [0750]    Blood Collection: Whole blood is collected in heparin-containing Vacutainer tubes (BD or equivalent). 
         [0751]    Determining absolute cell counts: TruCount Tubes (BD Biosciences or equivalent) are utilized to determine accurate cell counts. Cells are stained with fluorescently labeled antibodies against the following maker (human). CD19. 
         [0752]    B Cell counts are determined using a FACS Aria or FACS Calibur (BD Biosciences or equivalent). 
         [0753]    Isolating peripheral blood mononuclear cells (PBMCs): PBMCs are isolated from whole blood using Ficoll density gradient centrifugation (Histopaque, Sigma-Aldrich; Amersham; or equivalent). 
         [0754]    Cell sorting: Relevant subsets are separated. Cells are stained with fluorescently labeled antibodies against the following marker (human). CD19. The B Cells are defined as: CD 19 + . B cells are isolated using a FACS Aria, FACS Calibur (BD Biosciences) or equivalent. 
         [0755]    CELL SURFACE Receptor Quantification: The FACS-sorted B cells collected above are stained with phycoerythrin (PE) conjugated antibodies against one or more of the following targets: BAFF-R, APRIL, BCMA, and HSPG. 
         [0756]    One or more of the following reagents (or equivalent) is utilized: 
         [0757]    PE Anti-human CD268 (BAFF-R) Antibody (Catalog Number 316905, BioLegend, San Diego, Calif. USA) or PE Mouse Anti-Human BAFF Receptor (Catalog Number 558097 Becton Dickinson Biosciences, San Jose, Calif. USA) 
         [0758]    Polyclonal Anti-human BCMA/TNFRSF17-Phycoerythrin (Catalog Number: FAB193P, R&amp;D Systems, Minneapolis, Minn. USA). 
         [0759]    Monoclonal Anti-human TACI/TNFRSF13B/CD267-Phycoerythrin (Catalog Number: FAB1741P, R&amp;D Systems, Minneapolis, Minn. USA) or PE Rat anti-Human CD267 (Catalog Number 558414 Becton Dickinson Biosciences, San Jose, Calif. USA). 
         [0760]    Anti-HSPG antibody 3G10 (Seikagaku, Japan). 
         [0761]    INTRACELLULAR AND CELL SURFACE Receptor Quantification: After quantifying only the cell surface receptors using the above procedure, the cells can then be permeabilized using CytoFix/Cytoperm (Catalog Number 554722, Becton Dickinson Biosciences, San Jose, Calif. USA) or equivalent. Then the above “Cell Surface Receptor Quantification” procedure can be repeated, but in this case will yield the total (intracellular+cell surface) receptor levels. The intracellular levels can then be calculated for each receptor by subtracting the surface levels from the total levels as in [Hodge, 2000]. 
         [0762]    Measure Cytokine Levels: Serum levels of BAFF and APRIL can be determined using an ELISA kit such as the Quantikine Human BAFF/BLyS/TNFSF13B Immunoassay (Catalog Number DBLYS0, SBLYS0, or PDBLYS, R&amp;D Systems, Minneapolis, Minn. USA), and APRIL Human ELISA Kit (Catalog Number KHC3051, Invitrogen/Life Technologies, Carlsbad Calif. USA). 
         [0763]    In one embodiment, the measurements resulting from the above protocols comprise the initial conditions that are input into the computational model as defined in the table below. In this example, Cell Type A is defined to be B cells, but in other embodiments it could be other cell types, or repeated for multiple cell types. Note that BR3 is the BAFF receptor. 
         [0000]    
       
         
               
             
               
               
             
           
               
                   
               
               
                 Table of Measured Parameters: Initial Conditions (t = 0) 
               
             
          
           
               
                 parameter 
                 Definition 
               
               
                   
               
               
                 R S   CellTypeA:BR3 [t = 0] 
                 Surface BR3 receptor subunits per Cell Type A 
               
               
                 R S   CellTypeA:TACI [t = 0] 
                 Surface TACI receptors per Cell Type A 
               
               
                 R S   CellTypeA:BCMA [t = 0] 
                 Surface BCMA receptors per Cell Type A 
               
               
                 R S   CellTypeA:HSPG [t = 0] 
                 Surface HSPG per Cell Type A 
               
               
                 R i   CellTypeA:BR3 [t = 0] 
                 Internal BR3 receptor subunits per Cell Type A 
               
               
                 R i   CellTypeA:TACI [t = 0] 
                 Internal TACI receptors per Cell Type A 
               
               
                 R i   CellTypeA:BCMA [t = 0] 
                 Internal BCMA receptors per Cell Type A 
               
               
                 R i   CellTypeA:HSPG [t = 0] 
                 Internal HSPG per Cell Type A 
               
               
                 L BAFF [t = 0] 
                 Concentration of BAFF in serum 
               
               
                 L APRIL [t = 0] 
                 Concentration of APRIL in serum 
               
               
                 Y CellTypeA [t = 0] 
                 Cell count of Cell Type A 
               
               
                   
               
             
          
         
       
     
         [0764]    In one particular embodiment, the following format is used to define relevant parameters to represent interactions: 
         [0000]    kf_X_Y is defined as the surface forward rate constant of X binding to Y.
 
kr_X_Y is defined as the surface reverse rate constant of X binding to Y.
 
kfe_X_Y is defined as the internal forward rate constant of X binding to Y.
 
kre_X_Y is defined as the internal reverse rate constant of X binding to Y.
 
ksyn_X_Y is defined as the rate at which X in synthesized in response to the binding event indicated in Y.
 
kt_celltypea_X is defined as the constitutive internalization rate of X on cell type a.
 
ke_celltypea_X is defined as the internalization rate of X on cell type a.
 
kh_celltypea_X is defined as the degradation rate of X on cell type a.
 
kx_celltypea_X is defined as the recycling rate of X on cell type a.
 
vs_celltypea_X is defined as the rate at which X is synthesized on cell type a.
 
         [0765]    In one particular embodiment, using the above format to define parameters, the following parameters are provided from literature values as indicated, although in other embodiments other values may be used or the values may be measured: 
         [0766]    kr_baff_br3=(1.3e-2)*60;% min ̂-1 [Day, 2005] 
         [0767]    kf_baff_br3=kr_baff_br3/16;% nM, [Treml, 2009] 
         [0768]    kr_baff_taci=(1.3e-2)*60;% min ̂-1 TEMP: assume same as br3 
         [0769]    kf_baff_taci=kr_baff_taci/0.2;% nM, [Treml, 2009] 
         [0770]    kr_april_taci=(1.3e-2)*60;% min ̂-1 TEMP: assume same as br3 
         [0771]    kf_april_taci=kr_april_taci/6.4;% nM, [Treml, 2009] kr_baff_bcma=(1e-1)*60;% min ̂-1 [Day, 2005] 
         [0772]    kf_baff_bcma=kr_baff_bcma/1600;% nM, [Treml, 2009] kr_april_bcma=(5.6e-3)*60;% min ̂-1 [Day, 2005] 
         [0773]    kf_april_bcma=kr_april_bcma/16;% nM, [Treml, 2009] 
         [0774]    kr_april_hspg=(1.3e-2)*60;% min ̂-1 TEMP: assume same as br3 
         [0775]    kf_april_hspg=kr_april_hspg/1600;% nM TEMP: assume same as BAFF-BCMA 
         [0776]    kre_baff_br3=8*kr_baff_br3;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0777]    kfe_baff_br3=kre_baff_br3/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0778]    kre_baff_taci=8*kr_baff_taci;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0779]    kfe_baff_taci=kre_baff_taci/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0780]    kre_april_taci=8*kr_april_taci;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0781]    kfe_april_taci=kre_april_taci/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0782]    kre_baff_bcma=8*kr_baff_bcma;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0783]    kfe_baff_bcma=kre_baff_bcma/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0784]    kre_april_bcma=8*kr_april_bcma;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0785]    kfe_april_bcma=kre_april_bcma/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0786]    kre_april_hspg=8*kr_april_hspg;% min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0787]    kfe_april_hspg=kre_april_hspg/1000;% nM̂-1,min ̂-1 TEMP: same proportion as IL-2 [Fallon, 2000] 
         [0788]    %Constitutive Internalization 
         [0789]    kt_celltypea_br3=0.007;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0790]    kt_celltypea_taci=0.007;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0791]    kt_celltypea_bcma=0.007;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0792]    kt_celltypea_hspg=0.007;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0793]    %Constitutive Receptor Synthesis Rate 
         [0794]    vs_celltypea_taci=kt_celltypea_taci*Y0(3);%Balance internalization, maintain initial number 
         [0795]    vs_celltypea_br3=kt_celltypea_br3*Y0(1);% Balance internalization, maintain initial number 
         [0796]    vs_celltypea_bcma=kt_celltypea_bcma*Y0(5);% Balance internalization, maintain initial number 
         [0797]    vs_celltypea_hspg=kt_celltypea_hspg*Y0(7);% Balance internalization, maintain initial number 
         [0798]    %vs_celltypea_taci=11;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0799]    %vs_celltypea_br3=11;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0800]    %vs_celltypea_bcma=11;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0801]    %vs_celltypea_hspg=11;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0802]    %Induced Receptor Synthesis Rate 
         [0803]    ksyn_celltypea_baff_br3=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0804]    ksyn_celltypea_baff_taci=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0805]    ksyn_april_taci=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0806]    ksyn_celltypea_baff_bcma=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0807]    ksyn_celltypea_april_bcma=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0808]    ksyn_celltypea_april_hspg=0.0011;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0809]    %Degradation Rate Constant 
         [0810]    kh_celltypea_br3=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0811]    kh_celltypea_baff_br3=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0812]    kh_celltypea_taci=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0813]    kh_celltypea_bcma=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0814]    kh_celltypea_hspg=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0815]    kh_celltypea_baff_taci=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0816]    kh_celltypea_baff_bcma=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0817]    kh_celltypea_april_taci=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0818]    kh_celltypea_april_bcma=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0819]    kh_celltypea_april_hspg=0.035;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0820]    %Internalization Rate Constant 
         [0821]    ke_celltypea_baff_br3=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0822]    ke_celltypea_baff_taci=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0823]    ke_celltypea_baff_bcma=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0824]    ke_celltypea_april_taci=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0825]    ke_celltypea_april_bcma=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0826]    ke_celltypea_april_hspg=0.04;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0827]    other_factors_affecting_br3_synthesis=0;%TEMP 
         [0828]    other_factors_affecting_taci_synthesis=0;%TEMP 
         [0829]    other_factors_affecting_bcma_synthesis=0;%TEMP 
         [0830]    other_factors_affecting_hspg_synthesis=0;%TEMP 
         [0831]    %Recycling Rate Constant 
         [0832]    kx_celltypea_baff=0.15;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0833]    kx_celltypea_april=0.15;% min ̂-1 TEMP: same as IL-2 [Fallon, 2000] 
         [0834]    ye=10̂-14;% L/cell [Fallon, 2000]total endosomal volume 
         [0835]    na=6.02e23/(10̂9); % Avogadro&#39;s Number, units in nM 
         [0836]    In one embodiment, the method for assessing the provided values comprises the following equations: 
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             
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         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
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                             CellTypeA 
                             : 
                             
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         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             TACI 
                           
                         
                       
                       
                          
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                               : 
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                         · 
                         
                           
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                               : 
                               
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                            
                           
                             [ 
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                             ] 
                           
                         
                       
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                             : 
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                             [ 
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                         · 
                         
                           
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                               CellTypeA 
                               : 
                               
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                                 : 
                                 TACI 
                               
                             
                           
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                             [ 
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                             ] 
                           
                         
                       
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                             CellTypeA 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
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                               CellTypeA 
                               : 
                               TACI 
                             
                           
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                         V 
                         S 
                         
                           CellTypeA 
                           : 
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                       + 
                       
                         
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                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
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                         · 
                         
                           
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                               CellTypeA 
                               : 
                               
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                                 : 
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                             [ 
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                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
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                         · 
                         
                           
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                               CellTypeA 
                               : 
                               
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                                 : 
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                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
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                         ( 
                         
                           other_factors 
                            
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                            
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                            
                           _synthesis 
                         
                         ) 
                       
                     
                   
                 
                 
                   3 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             TACI 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
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                               : 
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                         · 
                         
                           
                             L 
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                               CellTypeA 
                               : 
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                            
                           
                             [ 
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                               : 
                               
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                                 : 
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                               : 
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                            
                           
                             [ 
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                             : 
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                         · 
                         
                           
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                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
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                             ] 
                           
                         
                       
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                             CellTypeA 
                             : 
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                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
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                             ] 
                           
                         
                       
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                             CellTypeA 
                             : 
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                         · 
                         
                           
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                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   4 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             L 
                             BAFF 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           f 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             APRIL 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           V 
                           S 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                          
                         
                           [ 
                           t 
                           ] 
                         
                       
                       + 
                       
                         
                           k 
                           syn 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           syn 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           other_factors 
                            
                           _affecting 
                            
                           _BCMA 
                            
                           _synthesis 
                         
                         ) 
                       
                     
                   
                 
                 
                   5 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               BAFF 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           fe 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               APRIL 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   6 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           S 
                           
                             CellTypeA 
                             : 
                             HSPG 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             f 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             L 
                             APRIL 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           r 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         V 
                         S 
                         
                           CellTypeA 
                           : 
                           HSPG 
                         
                       
                       + 
                       
                         
                           k 
                           syn 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           other_factors 
                            
                           _affecting 
                            
                           _HSPG 
                            
                           _synthesis 
                         
                         ) 
                       
                     
                   
                 
                 
                   7 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           R 
                           i 
                           
                             CellTypeA 
                             : 
                             HSPG 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           - 
                           
                             k 
                             fe 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               APRIL 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           re 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           t 
                           
                             CellTypeA 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   8 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             BAFF 
                             : 
                             
                               BR 
                                
                               
                                   
                               
                                
                               3 
                             
                           
                         
                         · 
                         
                           
                             L 
                             BAFF 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             BAFF 
                             : 
                             
                               BR 
                                
                               
                                   
                               
                                
                               3 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   9 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             BAFF 
                             : 
                             
                               BR 
                                
                               
                                   
                               
                                
                               3 
                             
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               BAFF 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             BAFF 
                             : 
                             
                               BR 
                                
                               
                                   
                               
                                
                               3 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTyprA 
                             : 
                             
                               BAFF 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               
                                 BR 
                                  
                                 
                                     
                                 
                                  
                                 3 
                               
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   10 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               TACI 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             BAFF 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             L 
                             BAFF 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             BAFF 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   11 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               TACI 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             BAFF 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               BAFF 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             BAFF 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   12 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             BAFF 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   13 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               BAFF 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               BAFF 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   14 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               TACI 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             APRIL 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             L 
                             APRIL 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             APRIL 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   15 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               TACI 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             APRIL 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               APRIL 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               TACI 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             APRIL 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               TACI 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   16 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             APRIL 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   17 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               APRIL 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               BCMA 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             APRIL 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               BCMA 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   18 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           S 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           f 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             L 
                             APRIL 
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             S 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           r 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   19 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           C 
                           i 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           fe 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             L 
                             i 
                             
                               CellTypeA 
                               : 
                               APRIL 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                         · 
                         
                           
                             R 
                             i 
                             
                               CellTypeA 
                               : 
                               HSPG 
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           re 
                           
                             APRIL 
                             : 
                             HSPG 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           e 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             C 
                             S 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       - 
                       
                         
                           k 
                           h 
                           
                             CellTypeA 
                             : 
                             
                               APRIL 
                               : 
                               HSPG 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 APRIL 
                                 : 
                                 HSPG 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   20 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           BAFF 
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   f 
                                   
                                     BAFF 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 BAFF 
                               
                             
                             + 
                             
                               
                                 
                                   k 
                                   r 
                                   
                                     BAFF 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     C 
                                     S 
                                     
                                       
                                         CellTypeA 
                                         : 
                                         
                                           BAFF 
                                           : 
                                           
                                             BR 
                                              
                                             
                                                 
                                             
                                              
                                             3 
                                           
                                         
                                       
                                        
                                       
                                           
                                       
                                     
                                   
                                   [ 
                                     
                                 
                               
                                
                               
                                   
                               
                                
                               
                                   
                                 t 
                                 ] 
                               
                             
                              
                             
                                 
                             
                             - 
                             
                               
                                 k 
                                 f 
                                 
                                   BAFF 
                                   : 
                                   TACI 
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     TACI 
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 BAFF 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   BAFF 
                                   : 
                                   TACI 
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BAFF 
                                       : 
                                       TACI 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 f 
                                 
                                   BAFF 
                                   : 
                                   BCMA 
                                 
                               
                               · 
                               
                                 
                                   R 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     BCMA 
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 BAFF 
                               
                             
                             + 
                             
                               
                                 k 
                                 r 
                                 
                                   BAFF 
                                   : 
                                   BCMA 
                                 
                               
                               · 
                               
                                 
                                   C 
                                   S 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BAFF 
                                       : 
                                       BCMA 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 x 
                                 
                                   CellTypeA 
                                   : 
                                   BAFF 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   BAFF 
                                 
                               
                               · 
                               
                                 V 
                                 e 
                               
                               · 
                               
                                 N 
                                 A 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           
                             
                               Y 
                               CellTypeA 
                             
                              
                             
                               [ 
                               t 
                               ] 
                             
                           
                           
                             N 
                             A 
                           
                         
                       
                       + 
                       
                         ( 
                         
                           repeat_above 
                            
                           _for 
                            
                           _additional 
                            
                           _cell 
                            
                           _types 
                         
                         ) 
                       
                     
                   
                 
                 
                   21 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             BAFF 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
                                   fe 
                                   
                                     BAFF 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   BAFF 
                                 
                               
                             
                             + 
                             
                               
                                 
                                   k 
                                   re 
                                   
                                     BAFF 
                                     : 
                                     
                                       BR 
                                        
                                       
                                           
                                       
                                        
                                       3 
                                     
                                   
                                 
                                 · 
                                 
                                   
                                     C 
                                     i 
                                     
                                       
                                         CellTypeA 
                                         : 
                                         
                                           BAFF 
                                           : 
                                           
                                             BR 
                                              
                                             
                                                 
                                             
                                              
                                             3 
                                           
                                         
                                       
                                        
                                       
                                           
                                       
                                     
                                   
                                    
                                   
                                       
                                   
                                   [ 
                                     
                                 
                               
                                
                               
                                   
                                 t 
                                 ] 
                               
                             
                              
                             
                                 
                             
                             - 
                             
                               
                                 k 
                                 fe 
                                 
                                   BAFF 
                                   : 
                                   TACI 
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     TACI 
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   BAFF 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   BAFF 
                                   : 
                                   TACI 
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BAFF 
                                       : 
                                       TACI 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                             - 
                             
                               
                                 k 
                                 fe 
                                 
                                   BAFF 
                                   : 
                                   BCMA 
                                 
                               
                               · 
                               
                                 
                                   R 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     BCMA 
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                               · 
                               
                                 L 
                                 i 
                                 
                                   CellTypeA 
                                   : 
                                   BAFF 
                                 
                               
                             
                             + 
                             
                               
                                 k 
                                 re 
                                 
                                   BAFF 
                                   : 
                                   BCMA 
                                 
                               
                               · 
                               
                                 
                                   C 
                                   i 
                                   
                                     CellTypeA 
                                     : 
                                     
                                       BAFF 
                                       : 
                                       BCMA 
                                     
                                   
                                 
                                  
                                 
                                   [ 
                                   t 
                                   ] 
                                 
                               
                             
                           
                           ) 
                         
                         · 
                         
                           1 
                           
                             
                               V 
                               e 
                             
                             · 
                             
                               N 
                               A 
                             
                           
                         
                       
                       - 
                       
                         
                           k 
                           x 
                           
                             CellTypeA 
                             : 
                             BAFF 
                           
                         
                         · 
                         
                           L 
                           i 
                           
                             CellTypeA 
                             : 
                             BAFF 
                           
                         
                       
                     
                   
                 
                 
                   22 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           d 
                           
                             CellTypeA 
                             : 
                             BAFF 
                           
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           k 
                           h 
                           
                             BAFF 
                             : 
                             
                               BR 
                                
                               
                                   
                               
                                
                               3 
                             
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 
                                   BR 
                                    
                                   
                                       
                                   
                                    
                                   3 
                                 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             BAFF 
                             : 
                             TACI 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 TACI 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                       + 
                       
                         
                           k 
                           h 
                           
                             BAFF 
                             : 
                             BCMA 
                           
                         
                         · 
                         
                           
                             C 
                             i 
                             
                               CellTypeA 
                               : 
                               
                                 BAFF 
                                 : 
                                 BCMA 
                               
                             
                           
                            
                           
                             [ 
                             t 
                             ] 
                           
                         
                       
                     
                   
                 
                 
                   23 
                 
               
             
           
         
       
     
         [0000]    
       
         
           
               
             
               
                 
                   
                     
                       
                          
                         
                           L 
                           APRIL 
                         
                       
                       
                          
                         t 
                       
                     
                     = 
                     
                       
                         
                           ( 
                           
                             
                               
                                 - 
                                 
                                   k 
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         [0000]    In one embodiment, the therapy is a BAFF antagonist and the therapy&#39;s expected effect is to reduce the concentration of BAFF in serum In one embodiment, these equations are solved with MATLAB in order to examine the effect of a BAFF antagonist on the competition between BAFF and APRIL for binding to TACI. This is relevant because the “negative regulation is mediated via the BAFF:TACI interaction, while positive effects (e.g., IgA production, proliferation) are transmitted via APRIL:TACI/HSPG interactions.” [Salzer, 2007].  FIG. 4  shows the output of such a model.  FIG. 4(   a ) illustrates a first subject before (left) and after (right) treatment. The subject has lower initial APRIL levels, so the BAFF antagonist will NOT be effective because even after the addition of the BAFF antagonist (as represented by a reduction in BAFF concentration from 0.18 nM to 0.044 nM), the negative signaling (mediated by BAFF:TACI) still exceeds the positive signaling (mediated by APRIL:TACI). In contrast, the second subject (illustrated in  FIG. 4(   b )) has higher initial APRIL levels before treatment (left), so the BAFF antagonist WILL be effective because after the addition of the BAFF antagonist (as represented by a reduction in BAFF concentration from 0.18 nM to 0.044 nM) (right), the negative signaling (mediated by BAFF:TACI) NO LONGER exceeds the positive signaling (mediated by APRIL:TACI). 
       Example 3 
     Predicting the Effects of a JAK Inhibitor 
       [0837]    In one embodiment, the therapy is an inhibitor of a janus kinase (JAK). In another embodiment, the therapy is specifically an inhibitor of JAK3. The therapy&#39;s target receptor subunit is CD132. The ligands that interacts with the therapy&#39;s target receptor subunits are IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunits that interact with the therapy&#39;s target receptor subunits are CD25, CD122, CD124, CD127, CD129, IL-15Ralpha, and IL-21Ralpha. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The receptor subunits that interact with receptor subunits and ligands that bind to receptor subunits that interact with receptor subunits are TSLPR, IL-13Ralpha1, TSLP, and IL-13. A receptor subunit that binds to a ligand is IL-13Ralpha2. 
         [0838]    In one embodiment, the materials, methods, and model from Example 1 are used to determine the extent of signaling caused by each cytokine. The effects of the therapy are predicted based on which gamma chain cytokine signals are present in a given subject. For instance, rheumatoid arthritis (RA) is believed to be mediated by Th17 and/or Th1 cells [Lubberts, 2010]. IL-21 is shown to increase the likelihood that naïve CD4+ T cells will develop into Th17 cells, and consistent with the two aforementioned observations is the fact that IL-21/IL-21R pathway blockade ameliorates disease in animal models of RA [Young, 2007]. On the other hand, IL-2 and IL-4 together increase the likelihood that naïve CD4+ T cells will develop in to Th2 cells, and a transient rise in synovial fluid IL-2 and IL-4 levels in early RA [Raza, 2005]. We hypothesize that if the analysis described above determines that IL-21 signaling is the dominant gamma chain signaling in a given RA subject at a given time, then the Jak3 inhibitor is likely to be effective because it will reduce the likelihood that naïve CD4+ T cells will become disease-producing Th17 cells. On the other hand, if IL-2 and/or IL-4 is/are the dominant gamma chain signaling in a given RA subject at a given time, then the Jak3 inhibitor is NOT likely to be effective because it will NOT reduce the likelihood that Th17 or Th1 cells will be generated. 
       Example 4 
     Predicting the Effects of Anti-IL-5 
       [0839]    In one embodiment, the therapy comprises an antibody against interleukin-5 (IL-5). The therapy&#39;s target receptor subunits are IL-5 receptor alpha and the common beta (βc) subunit. The ligand that interacts with the therapy&#39;s target receptor subunits is IL-5. The receptor subunits that interact with the therapy&#39;s target receptor subunits are GM-CSF receptor alpha subunit and IL-3 receptor alpha subunit. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: GM-CSF and IL-3. 
         [0000]    In one embodiment, the concentration of GM-CSF, IL-3, and IL-5 are determined in serum using commercially available ELISA kits. The surface and intracellular levels of IL-5 receptor alpha, GM-CSF receptor alpha, IL-3 receptor alpha, and beta common are determined on one or more relevant cell types. In one embodiment, the relevant cell types include eosinophils. In another embodiment, the relevant cell type is eosinophils. 
         [0840]    In one embodiment, a computational model is then used to determine the effect of the anti-IL-5 in a given subject at a given time, taking into account not only its direct effect on IL-5 but also the effects on GM-CSF and IL-3 signaling caused by the increased availability of beta common. 
       Example 5 
     Predicting the Effects of IL-21 
       [0841]    In one embodiment, the therapy is a recombinant IL-21. The therapy&#39;s target receptor subunits are IL-21Ralpha and CD132. The ligands that interact with the therapy&#39;s target receptor subunits are IL-21. The receptor subunits that interact with the therapy&#39;s target receptor subunits are CD25, CD122, CD124, CD127, CD129, and IL-15Ralpha. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-2, IL-4, IL-7, IL-9, IL-15. The receptor subunits that interact with receptor subunits and ligands that bind to receptor subunits that interact with receptor subunits are TSLPR, IL-13Ralpha1, TSLP, and IL-13. A receptor subunit that binds to a ligand is IL-13Ralpha2. 
         [0842]    In one embodiment, the materials, methods, and model from Example 1 are used to determine the effect of IL-21 in a given patient at a given time, taking into account not only its direct effects but also the indirect effects caused by the decreased availability of CD132. 
       Example 6 
     Predicting the Effects of IL-7 
       [0843]    In one embodiment, the therapy is a recombinant IL-7. The therapy&#39;s target receptor subunits are CD 127 and CD 132. The ligands that interacts with the therapy&#39;s target receptor subunits are IL-7. The receptor subunits that interact with the therapy&#39;s target receptor subunits are CD25, CD122, CD124, CD129, IL-15Ralpha, and IL-21Ralpha. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-2, IL-4, IL-7, IL-9, IL-15. The receptor subunits that interact with receptor subunits and ligands that bind to receptor subunits that interact with receptor subunits identified in are TSLPR, IL-13Ralpha1, TSLP, and IL-13. A receptor subunit that binds to a ligand is IL-13Ralpha2. 
         [0844]    In one embodiment, the materials, methods, and model from Example 1 are used to determine the effect of IL-7 in a given subject at a given time, taking into account not only its direct effects but also the indirect effects caused by the decreased availability of CD132. 
       Example 7 
     Predicting the Effects of IL-15 
       [0845]    In one embodiment, the therapy is a recombinant IL-15. The therapy&#39;s target receptor subunits are IL-15Ralpha, CD122, and CD132. The ligands that interacts with the therapy&#39;s target receptor subunits are IL-15. The receptor subunits that interact with the therapy&#39;s target receptor subunits are CD25, CD124, CD127, CD129, and IL-21Ralpha. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-2, IL-4, IL-7, IL-9, IL-15. The receptor subunits that interact with receptor subunits and ligands that bind to receptor subunits that interact with receptor subunits are TSLPR, IL-13Ralpha1, TSLP, and IL-13. A receptor subunit that binds to a ligand is IL-13Ralpha2. 
         [0846]    In one embodiment, the materials, methods, and model from Example 1 are used to determine the effect of IL-21 in a given patient at a given time, taking into account not only its direct effects but also the indirect effects caused by the decreased availability of CD132. 
       Example 8 
     Predicting the Effects of GM-CSF 
       [0847]    In one embodiment, the therapy comprises a recombinant GM-CSF, such as sargramostim. The therapy&#39;s target receptor subunits are GM-CSF receptor alpha and the common beta (βc) subunit. The ligand that interacts with the therapy&#39;s target receptor subunits is GM-CSF. The receptor subunits that interact with the therapy&#39;s target receptor subunits are the IL-5 receptor alpha subunit and the IL-3 receptor alpha subunit. The ligands that interact with receptor subunits that interact with the therapy&#39;s target receptor subunits are: IL-5 and IL-3. 
         [0848]    In one embodiment, the concentration of GM-CSF, IL-3, and IL-5 are determined in serum using commercially available ELISA kits. The surface and intracellular levels of IL-5 receptor alpha, GM-CSF receptor alpha, IL-3 receptor alpha, and beta common are determined on one or more relevant cell types. In one embodiment, the relevant cell types include eosinophils. In another embodiment, the relevant cell type is eosinophils. 
         [0849]    In one embodiment, a computational model is then used to determine the effect of the GM-CSF in a given patient at a given time, taking into account not only its direct effect but also the effects on IL-5 and IL-3 signaling caused by the decreased availability of beta common. 
       Example 9 
     Anti-CD25 Alternate Approach 
       [0850]    In another embodiment, the effects of an anti-CD25 therapy on a given subject are predicted by determining the extent to which it makes additional IL-2 available to CD56bright NK cells. In subjects with Tregs levels above a certain threshold, even the maximum dose of anti-CD25 may still leave a sufficient number of CD25+ Tregs available to compete for IL-2, such that CD56bright NK cells still will not be able to obtain enough IL-2 to reach their proliferation thresholds. In one embodiment, it is determined whether or not this is the case using measurements of Treg levels, CD56bright NK cell levels, quantity of CD25, CD122, and CD132 on the Tregs, quantity of CD25, CD122, and CD132 on the CD56bright NK cells, concentration of IL-2, and maximum anticipated dose of anti-CD25. In another embodiment, Tregs are divided into memory and naïve Tregs for the purpose of this analysis. In one embodiment, the determination is made using a computational model of receptor-ligand binding and trafficking dynamics. 
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