Abstract:
An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.

Description:
FIELD OF THE INVENTION  
         [0001]    The present invention generally relates to a system and method to effect the mitral valve annulus of a heart. The present invention more particularly relates to a mitral valve annulus device, system, and method wherein the device is deployed and anchored in the coronary sinus of a heart adjacent the mitral valve annulus to reshape the mitral valve annulus.  
         BACKGROUND OF THE INVENTION  
         [0002]    The human heart generally includes four valves. Of these valves, a most critical one is known as the mitral valve. The mitral valve is located in the left atrial ventricular opening between the left atrium and left ventricle. The mitral valve is intended to prevent regurgitation of blood from the left ventricle into the left atrium when the left ventricle contracts. In preventing blood regurgitation the mitral valve must be able to withstand considerable back pressure as the left ventricle contracts.  
           [0003]    The valve cusps of the mitral valve are anchored to muscular wall of the heart by delicate but strong fibrous cords in order to support the cusps during left ventricular contraction. In a healthy mitral valve, the geometry of the mitral valve ensures that the cusps overlie each other to preclude regurgitation of the blood during left ventricular contraction.  
           [0004]    The normal functioning of the mitral valve in preventing regurgitation can be impaired by dilated cardiomyopathy caused by disease or certain natural defects. For example, certain diseases may cause dilation of the mitral valve annulus. This can result in deformation of the mitral valve geometry to cause ineffective closure of the mitral valve during left ventricular contraction. Such ineffective closure results in leakage through the mitral valve and regurgitation. Diseases such as bacterial inflammations of the heart or heart failure can cause the aforementioned distortion or dilation of the mitral valve annulus. Needless to say, mitral valve regurgitation must not go uncorrected.  
           [0005]    One method of repairing a mitral valve having impaired function is to completely replace the valve. This method has been found to be particularly suitable for replacing a mitral valve when one of the cusps has been severely damaged or deformed. While the replacement of the entire valve eliminates the immediate problem associated with a dilated mitral valve annulus, presently available prosthetic heart valves do not possess the same durability as natural heart valves.  
           [0006]    Various other surgical procedures have been developed to correct the deformation of the mitral valve annulus and thus retain the intact natural heart valve function. These surgical techniques involve repairing the shape of the dilated or deformed valve annulus. Such techniques, generally known as annuloplasty, require surgically restricting the valve annulus to minimize dilation. Here, a prosthesis is typically sutured about the base of the valve leaflets to reshape the valve annulus and restrict the movement of the valve annulus during the opening and closing of the mitral valve.  
           [0007]    Many different types of prostheses have been developed for use in such surgery. In general, prostheses are annular or partially annular shaped members which fit about the base of the valve annulus. The annular or partially annular shaped members may be formed from a rigid material, such as a metal, or from a flexible material.  
           [0008]    While the prior art methods mentioned above have been able to achieve some success in treating mitral regurgitation, they have not been without problems and potential adverse consequences. For example, these procedures require open heart surgery. Such procedures are expensive, are extremely invasive requiring considerable recovery time, and pose the concomitant mortality risks associated with such procedures. Moreover, such open heart procedures are particularly stressful on patients with a compromised cardiac condition. Given these factors, such procedures are often reserved as a last resort and hence are employed late in the mitral regurgitation progression. Further, the effectiveness of such procedures is difficult to assess during the procedure and may not be known until a much later time. Hence, the ability to make adjustments to or changes in the prostheses to obtain optimum effectiveness is extremely limited. Later corrections, if made at all, require still another open heart surgery.  
           [0009]    An improved therapy to treat mitral regurgitation without resorting to open heart surgery has recently been proposed. This is rendered possible by the realization that the coronary sinus of a heart is near to and at least partially encircles the mitral valve annulus and then extends into a venous system including the great cardiac vein. As used herein, the term “coronary sinus” is meant to refer to not only the coronary sinus itself but in addition, the venous system associated with the coronary sinus including the great cardiac vein. The therapy contemplates the use of a device introduced into the coronary sinus to reshape and advantageously effect the geometry of the mitral valve annulus.  
           [0010]    The device includes an elongated flexible member having a cross sectional dimension for being received within the coronary sinus of the heart. The device includes an anchor at each of its ends. When placed in the coronary sinus, anchored and drawn taught, the device exerts an inward pressure on the mitral valve. The inward pressure increases the radius of curvature of the mitral valve annulus, or at least a portion of it, to promote effective valve sealing action and eliminate mitral regurgitation.  
           [0011]    The device may be implanted in the coronary sinus using only percutaneous techniques similar to the techniques used to implant cardiac leads such as pacemaker leads. One prior proposed system for implanting the device includes an elongated introducer configured for being releasably coupled to the device. The introducer is preferably flexible to permit it to advance the device into the heart and into the coronary sinus through the coronary sinus ostium. To promote guidance, an elongated sheath is first advanced into the coronary sinus. Then, the device and introducer are moved through a lumen of the sheath until the device is in position within the coronary sinus. Because the device is formed of flexible material, it conforms to the curvatures of the lumen as it is advanced through the sheath. The sheath is then partially retracted. The distal end of the device is then anchored. Then, the sheath is retracted proximally past the proximal end of the device. The introducer is then drawn proximally to place the device in tension, where upon the proximal anchor is set. The procedure is then completed by the release of the introducer from the device and retraction of the introducer and sheath. As a result, the device is left, within the coronary sinus to exert the inward pressure on the mitral valve annulus.  
           [0012]    While the foregoing represents great adjunctment in the art, further improvement is possible. For example, in the prior delivery system, described hereinbefore, release of the introducer from the device is difficult. The device and introducer carried interlocking couplers which required an uncoupling action to be applied to the introducer to unlock the device from the introducer. This action could cause the device position to change and adversarily alter its effectiveness. Still further, neither the device nor the introducer were well suited for recapturing the device for removal. Recapture and removal of the device may be advisable if exchange to a device of different dimension is considered to be more appropriate for a given patient.  
           [0013]    Hence, there is a need for a more effective device, delivery assembly, and method to deliver a mitral valve annulus therapy device into the coronary sinus adjacent the mitral valve annulus and to release the device in a manner which leaves the device positioning unaffected. Still further, there is a need for such a device and assembly which provides recapture of the device should such recapture be required for removal of the device. The present invention addresses these needs.  
         SUMMARY OF THE INVENTION  
         [0014]    The invention provides an assembly for effecting the condition of a mitral valve annulus of a heart. The assembly includes a mitral valve therapy device that reshapes the mitral valve annulus of the heart when placed within the coronary sinus of the heart adjacent the mitral valve annulus. The mitral valve therapy device has a proximal end including a coupling structure. The assembly further includes a catheter having a lumen that directs the mitral valve therapy device into the coronary sinus of the heart, a second coupling structure that is lockable on the device coupling structure, and a locking member that locks the device coupling structure to the second coupling structure and that releases the device coupling structure from the second coupling structure.  
           [0015]    The assembly may further include a pusher member that pushes the device through the catheter lumen. The pusher member has a distal end that engages the device proximal end. The pusher member may carry the second coupling structure at the distal end of the pusher member.  
           [0016]    The device coupling structure may comprise a hoop structure. The second coupling structure may also comprise a hoop structure. The locking member comprises a pin that extends through the hoop structures to lock the coupling structures together and that is retractable to release the hoop structures. The catheter has a distal end and the pin is preferably long enough to extend through the distal end of the catheter. The pusher member may be an elongated coil.  
           [0017]    The device coupling structure and the second coupling structure may alternatively comprise a pair of interlocking structures and the locking member may comprise a slide-lock sheath closely fitted to the interlocking structures. The interlocking structures and the slide-lock sheath may be tubular. The pusher member has a distal end that engages the device proximal end, and carries the second coupling structure. The locking member may further include a tether that extends from the slide-lock sheath to and through the catheter lumen to permit the tether to pull proximally on the slide-lock sheath for releasing the interlocking structures.  
           [0018]    The assembly may further include a retractor configured to extend through the catheter lumen and grip the device coupler. This permits retraction of the device through the catheter.  
           [0019]    The invention further provides an assembly for effecting the condition of a mitral valve annulus of a heart comprising device means for reshaping the mitral valve annulus of the heart when placed within the coronary sinus of the heart adjacent the mitral valve annulus. The device means has a proximal end including a coupling means for coupling the device means. The assembly further comprises catheter means having a lumen that directs the mitral valve therapy device into the coronary sinus of the heart, second coupling means for locking with the device coupling means, and locking means for locking the device coupling means to the second coupling means and releasing the device coupling means from the second coupling means.  
           [0020]    The present invention further provides a method of implanting a mitral valve therapy device to effect the condition of a mitral valve annulus of a heart. The method includes the steps of feeding a catheter having a lumen into the coronary sinus of the heart, locking the device to a deployment member with a locking member, and directing the mitral valve therapy device through the catheter lumen into the coronary sinus with the deployment member. The method further includes the steps of positioning the mitral valve therapy device in the coronary sinus with the deployment member, releasing the locking member from the device and the deployment member coupler, removing the deployment member and the locking member from the catheter lumen, and removing the catheter from the coronary sinus.  
           [0021]    The invention still further provides a method of effecting the condition of a mitral valve annulus of a heart. The method includes the steps of feeding a catheter having a lumen into the coronary sinus of the heart, aligning a mitral valve therapy device coupler of a mitral valve therapy device to a deployment member coupler, and locking the device coupler to the deployment member coupler with a locking member. The method further includes directing the mitral valve therapy device through the catheter lumen into the coronary sinus with the deployment member, positioning the mitral valve therapy device in the coronary sinus with the deployment member, releasing the locking member from the device coupler and the deployment member coupler, removing the deployment member, the deployment member coupler and the locking member from the catheter lumen, and removing the catheter from the coronary sinus.  
           [0022]    The invention further provides an assembly for effecting the condition of a mitral valve annulus of a heart which includes a mitral valve therapy device that reshapes the mitral valve annulus of the heart when placed within the coronary sinus of the heart adjacent the mitral valve annulus, the mitral valve therapy device having a proximal end including a coupling structure and a guide member that directs the mitral valve therapy device into the coronary sinus of the heart. The assembly further includes a second coupling structure that is lockable on the device coupling structure, and a locking member that locks the device coupling structure to the second coupling structure and that releases the device coupling structure from the second coupling structure.  
           [0023]    The invention further provides an assembly for effecting the condition of a mitral valve annulus of a heart. The assembly includes device means for reshaping the mitral valve annulus of the heart when placed within the coronary sinus of the heart adjacent the mitral valve annulus, the device means having a proximal end including a coupling means for coupling the device means, guide means for directing the mitral valve therapy device into the coronary sinus of the heart, second coupling means for locking with the device coupling means, and locking means for locking the device coupling means to the second coupling means and releasing the device coupling means from the second coupling means.  
           [0024]    The invention still further provides a method of implanting a mitral valve therapy device to effect the condition of a mitral valve annulus of a heart. The method includes the steps of feeding a guide member into the coronary sinus of the heart, locking the device to a deployment member with a locking member, directing the mitral valve therapy device along the guide member into the coronary sinus with the deployment member, positioning the mitral valve therapy device in the coronary sinus with the deployment member, releasing the locking member from the device and the deployment member coupler, and removing the deployment member, the locking member, and the guide member from the coronary sinus. 
       
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       [0025]    The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further aspects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like reference numerals identify identical elements, and wherein:  
         [0026]    [0026]FIG. 1 is a superior view of a human heart with the atria removed;  
         [0027]    [0027]FIG. 2 is a superior view of a human heart similar to FIG. 1 illustrating a mitral valve therapy device embodying the present invention deployed therein and which may be by deployed an assembly embodying the present invention;  
         [0028]    [0028]FIG. 3 is a superior view similar to FIG. 1 with portions cut away illustrating the device of FIG. 2 being deployed by a deployment assembly embodying the present invention;  
         [0029]    [0029]FIG. 4 is a partial perspective view to an enlarged scale illustrating the coupling members and locking member of a first embodiment of the present invention;  
         [0030]    [0030]FIG. 5 is a view similar to FIG. 4 illustrating the release of the coupling structures;;  
         [0031]    [0031]FIG. 6 is a superior view similar to FIG. 1 illustrating recapture of the deployed device;  
         [0032]    [0032]FIG. 7 is a partial perspective view to an enlarged scale illustrating the recapture of the device;  
         [0033]    [0033]FIG. 8 is a superior view similar to FIG. 1 illustrating a further embodiment of the present invention;  
         [0034]    [0034]FIG. 9 is a partial perspective view of the coupling and locking arrangement of FIG. 8; and  
         [0035]    [0035]FIG. 10 is a partial perspective view illustrating the release of the coupling members of FIG. 8. 
     
    
     DETAILED DESCRIPTION OF THE INVENTION  
       [0036]    Referring now to FIG. 1, it is a superior view of a human heart  10  with the atria removed to expose the mitral valve  12 , and the coronary sinus  14  of the heart  10 . Also generally shown in FIG. 1 are the pulmonary valve  22 , the aortic valve  24 , and the tricuspid valve  26  of the heart  10 .  
         [0037]    The mitral valve  12  includes an anterior cusp  16 , a posterior cusp  18  and an annulus  20 . The annulus encircles the cusps  16  and  18  and maintains their spacing to provide a complete closure during a left ventricular contraction. As is well known, the coronary sinus  14  partially encircles the mitral valve  12  adjacent to the mitral valve annulus  20 . As is also known, the coronary sinus is part of the venus system of the heart and extends along the AV groove between the left atrium and the left ventricle. This places the coronary sinus essentially within the same plane as the mitral valve annulus making the coronary sinus available for placement of the mitral valve therapy device of the present invention therein.  
         [0038]    [0038]FIG. 2 shows a mitral valve therapy device  30  embodying the present invention shown deployed in the coronary sinus  14  of the heart  10  adjacent the mitral valve annulus  20  for effecting the geometry of the mitral valve annulus. The device  30  takes the form of an elongated body  32  which includes a distal anchor  34  and a proximal anchor  36 .  
         [0039]    The anchors  34  and  36  are shown in FIG. 2 in their deployed configuration. A more complete description of the anchors  34  and  36  may be had in copending application Ser. No. 10/142,637, filed May 8, 2002 for BODY LUMEN DEVICE ANCHOR, DEVICE AND ASSEMBLY which is assigned to the assignee of the present invention and hereby incorporated herein by reference. In deploying the device  30  in the coronary sinus, the distal anchor  34  is first deployed to anchor the distal end of the device  30 . In the anchoring process, the anchor  34  is expanded outwardly to anchor the device in the coronary sinus against both bi-directional longitudinal and rotational movement. This allows the device  30  to be tightened within the coronary sinus by pulling of the device&#39;s proximal end. Then, the proximal anchor  36  is deployed. The device  30 , which may be formed from Nitinol or stainless steel, for example, now exerts an inward pressure on the mitral valve annulus  20  to advantageously effect its geometry.  
         [0040]    The device  30  along with its deployment system  50  is illustrated in FIG. 3. As shown, the device is in the process of being implanted in the coronary sinus  14  of the heart  10 . Its proximal anchor  36  and distal anchor  34  have yet been deployed. The deployment system  50  includes an elongated catheter  52 , an elongated pusher  54 , a coupling structural member  56  and a locking pin  58 . As may be noted in FIG. 4, the proximal end of the device  30  includes a coupling loop  38 . The pusher  54  is preferably an elongated coil having a center lumen  55 . The coupling member  56  is formed from a cable that is provided with a loop  57 . The legs or ends  59  of the loop  57  extend proximally through the lumen  55  and out the proximal end of the pusher  54 .  
         [0041]    The locking pin  58  also extends proximally out of the proximal end of the pusher  54 . As shown in FIG. 4, the coupling loops  38  and  57  are aligned to overlap and the locking pin  58  is extended through the overlapping loops. This causes the device  30  to be releasably locked to the pusher  54 .  
         [0042]    In deploying the device  30 , the catheter  52  is first fed into the coronary sinus  14  adjacent the mitral valve annulus  20 . The device  30  and pusher  54  are then releasably locked together as shown in FIG. 4. The device is then loaded into the catheter  52 . The pusher  54  follows the device into the catheter  52  and is then advanced along the catheter to push the device  30  distally down the catheter to a predetermined position adjacent the mitral valve annulus  14  at the distal end of the catheter  52 . Thereafter, the device is maintained in a stationary position by the pusher  54  as the catheter  52  is partially withdrawn to expose the distal anchor  34 . Once the distal anchor  34  is exposed, it is deployed in a manner as fully described in the aforementioned copending application Ser. No. 10/142,637. Once the distal anchor  34  is deployed, the catheter  50  is then retracted proximally of the proximal anchor  36 . This exposes the proximal anchor  36 . Once the proximal anchor is exposed, the pusher  54  is pulled proximally for tightening the device within the coronary sinus and to an extent which results in the desired effect on the geometry of the mitral valve annulus  20 . During this adjustment process, mitral regurgitation may be monitored and the device adjusted for optimal results. When the device  30  is in its final position within the coronary sinus  14 , the proximal anchor  36  may then be deployed. The beneficial effect of the device may now again be evaluated. Once the device is ready for chronic implant, the locking pin  58  may be pulled proximally from the proximal end of the pusher  54  as shown in FIG. 5 to disengage the coupling members  38  and  56 . With the pusher  54  now free from the device  30 , the pusher  54 , catheter  52 , coupling member  56  and locking pin  58  may then be removed from the heart.  
         [0043]    As can be appreciated by those skilled in the art, guide members, other than a guide catheter as shown herein, may be used to direct the device into the coronary sinus. For example, a guide wire, of the type well known in the art may alternatively be employed to guide the device there along into the coronary sinus without departing from the present invention.  
         [0044]    [0044]FIGS. 6 and 7 illustrate the manner in which the device  30  may be removed from the coronary sinus  14  if necessary in accordance with further aspects of the present invention. As may be seen in FIGS. 6 and 7, the device  30  may be removed from the coronary sinus  14  with a retractor assembly  60 . The retractor assembly includes the catheter  62 , and a retractor  64  comprising an elongated coil  65  and a coupling member  66 . The elongated coil  65  of the retractor  64  is essentially identical to the pusher  54  as illustrated in FIGS.  3 - 5 . The coupling member  66  may be a cable which extends down the center lumen of the elongated coil  65  to form a loop structure  66  and which then returns through the center lumen of the elongated coil  65  such that the free ends  69  of the cable  63  extend out the proximal end of the elongated coil  65 . As also seen in FIGS. 6 and 7, if the device  30  is to be removed from the coronary sinus  14 , the cable  63  is threaded into the elongated coil  65  to form the loop structure  66 . With the retractor  64  thus formed, the retractor is then guided down the catheter  62  to the proximal end of the device  30  and more specifically to the coupling loop member  38  of the device  30 . The loop  66  of the cable  63  is then wrapped about the loop coupling member  38  of the device  30  and the free ends  69  of the cable are drawn proximally to tighten the loop structure  66  about the loop coupling member  38 . The retractor  64  now has a grip on the device  30 . With the device  30  now being firmly held by the retractor  64 , the retractor  64  may be pulled proximally within the catheter  62  to impart proximal movement to the device  30 . When the anchors  34  and  36  of the device  30  engage the distal end of the catheter  62 , they will be collapsed to disengage from the coronary sinus. The device may now be removed by pulling on the retractor  64  proximally within the catheter  62  until the device is fully removed from the heart and the patient. Alternatively, the device may be drawn into the catheter. The catheter and the device may then be withdrawn together from the patient.  
         [0045]    FIGS.  8 - 10  illustrate a further embodiment of the present invention for releasably locking a pusher member to a mitral valve therapy device for implanting the mitral valve therapy device adjacent the mitral valve annulus within the coronary sinus of the heart.  
         [0046]    As illustrated in FIG. 8, the mitral valve therapy device  70  is elongated and includes a distal anchor  74  and a proximal anchor  76 . The anchors are not yet deployed. The device  70  further includes, at its proximal end, a coupling structure  78 .  
         [0047]    For deploying the device  70 , a deployment system  90  is also illustrated. The deployment system includes a catheter  92 , a pusher member  94 , a coupling structure  96  at the distal end of the pusher  94 , and a locking member  98 . As will be best seen in FIG. 9, the coupling member  78  of the device  70  and the coupling member  96  of the pusher  94  form a pair of interlocking structures. The coupling structures  78  and  96  are tubular and the locking member  98  is also tubular.  
         [0048]    When it is desired to implant the device  70 , the device  70  is coupled to the pusher  98  by the interlocking structures of the coupling members  78  and  96  which are held together and in place by the locking member  98 . Then, as previously described in the previous embodiment, the device and pusher member are fed down the catheter  92  until the device reaches a desired position within the coronary sinus adjacent the mitral valve annulus  20 . Once in this position, the device is held stationary by the pusher member  94  while the catheter  92  is retracted to expose the distal anchor  74 . The distal anchor  74  may now be deployed in a manner as described in the aforementioned copending application Ser. No. 10/142,637. With the distal anchor  74  deployed, the catheter  92  is then retracted until it is proximal to the proximal anchor  76 . The pusher  94  may then be pulled to tighten the device within the coronary sinus. Once the device  70  has been tightened to a desired degree, as confirmed by device effectiveness evaluation, the device  70  is ready for chronic implant.  
         [0049]    When the device  70  is to be left within the coronary sinus  14 , the tether  99  is pulled to slide the locking member  98  off of the interlocking structures  78  and  96 . The coupling structures of the pusher  94  may be prestressed for disengaging the coupling structure  78  of the device  70  when the locking member  98  is pulled proximal to the interlocking structures. The device  70  is now free from the pusher member  94 . The pusher member  94  together with the tether, locking member, and catheter  92  may be removed from the heart. With the implant of the device  70  completed, the device  70  is left within the coronary sinus adjacent the mitral valve annulus  20  to treat the mitral valve such as by eliminating mitral regurgitation.  
         [0050]    As illustrated in FIG. 10, the coupling structure  96  is prestressed to deflect outwardly when the tubular locking member  98  is pulled proximally to disengage the device  70  from the pusher  94 . Alternatively, the coupling structure  96  may be prestressed inwardly with a locking pin (not shown) extending into coupling stricture  78  to maintain the locked arrangement. Here, proximal pulling of the pin would cause the coupling structure  96  to deflect inwardly to disengage the coupling structure  78  and  96 .  
         [0051]    While particular embodiments of the present invention have been shown and described, modifications may be made, and it is therefore intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.