Abstract:
A method for manufacturing a needle tapered along the longitudinal direction by electroforming comprises: a step of immersing a core material ( 122 ) having an outer peripheral surface that is tapered along the longitudinal direction in an electrolyte and forming a first electroformed body ( 126 ) on an outer peripheral surface ( 124 ) of the core material ( 122 ); a step of immersing the first electroformed body ( 126 ) in an electrolyte to which particles having a prescribed particle size are added and forming a second electroformed body ( 134 ) having multiple protrusions ( 30 ) on an outer peripheral surface ( 128 ) of the first electroformed body ( 126 ); a step of cutting the first electroformed body ( 126 ) and second electroformed body ( 134 ) into a prescribed length and forming a needle ( 10 ) having a sharp needle tip ( 16 ); and a step of pulling out the core material ( 122 ) from the cut first electroformed body ( 126 ).

Description:
FIELD OF THE INVENTION 
       [0001]    The present invention relates to a needle having a tapered shape formed by electroforming, and a method for manufacturing the same. 
       BACKGROUND OF THE ART 
       [0002]    A tool that punctures a living body with a needle is used to inject a liquid medicine into the living body, or extract a body fluid of the living body. When the needle attached to such a tool has a large external diameter, it is said that large pain is caused because a resistance force from the living body increases. For this reason, painless needles have been developed with the external diameter of the needles formed as thin as possible in order to reduce the pain. 
         [0003]    In this case, because the needles formed in a thin shape have a small internal diameter, for example, the needles have a large flow resistance during injection of a liquid medicine into the living body. For this reason, a tapered needle has been presented (see Patent Literature 1). The tapered needle has a needle proximal portion having a diameter larger than the diameter of a needle distal portion, to reduce the flow resistance. 
         [0004]    For example, the conventional tapered painless needles are formed with a thin external diameter, by rolling up a stainless plate material or elongating a stainless cylindrical member. However, in the case of a needle formed by rolling up a plate material, the joined portion of the rolled plate material needs to be processed with high accuracy. In addition, in the case of a needle formed by elongating a cylindrical member, rust due to the elongation may occur on the internal peripheral surface, and therefore the processing is very difficult. Accordingly, manufacturing of these needles requires much time and great cost. 
         [0005]    To solve the above problems, a method for forming a needle by electroforming has been presented (Patent Literatures 2 and 3). In the method, a core material having a diameter corresponding to a passage of the needle is immersed in an electrolyte, an electroformed member is formed on an external peripheral surface of the core material, thereafter the core material is pulled out of the electroformed member, and an end portion of the electroformed member is ground to have an acute angle. 
       REFERENCE OF THE PRIOR ART 
       [0006]    Patent Reference 1: Japanese Patent Application Publication No. 2008-200528 
         [0007]    Patent Reference 2: Japanese Patent Application Publication No. 2012-5576 
         [0008]    Patent Reference 3: Japanese Patent Application Publication No. 2006-291345 
       DISCLOSURE OF THE INVENTION 
     Problems the Invention is Intended to Solve 
       [0009]    However, even with a thin needle formed by electroforming, the pain felt by the living body is not sufficiently reduced. For example, the human body has 100 to 200 pain spots per square centimeter as sensory regions to sense pain. Pain occurs by stimulation of pain spots with the needle. The probability that the needle stimulates the pain spot is reduced by reducing the external diameter of the needle. However, even with the very small external diameter, occurrence of pain is not entirely avoided, because the external peripheral surface can contact the pain spots when the needle is caused to puncture and be inserted into the body. 
         [0010]    An object of the present invention is to provide a needle that reduces pain during puncture, has small flow distance in a needle tube passage, and can be manufactured with high accuracy at low cost, and a method for manufacturing the same. 
       SUMMARY OF THE INVENTION 
       [0011]    In accordance with an aspect of the present invention, a needle comprises a needle tube formed by electroforming and having a tapered shape along a longitudinal direction, the needle tube being provided with a plurality of projections formed by electroforming on an external peripheral surface of the needle tube, the projections having intervals of 0.2 to 100 μm between adjacent top portions thereof, and a height of 0.1 to 50 μm from the external peripheral surface. 
         [0012]    In the needle, projections include particles including at least one selected from the group consisting of silicon carbide, sapphire, diamond, and alumina ceramics. 
         [0013]    In the needle, the tapered shape is a curved shape along the longitudinal direction. 
         [0014]    In the needle, the tapered shape is a straight shape along the longitudinal direction. 
         [0015]    In the needle, the needle is an injection needle. 
         [0016]    In accordance with an aspect of the present invention, a method for manufacturing a needle having a tapered shape along a longitudinal direction by electroforming, the method comprise
       a step of immersing a core material including an external peripheral surface having a tapered shape along the longitudinal direction in an electrolyte, to form a first electroformed member on the external peripheral surface of the core material;   a step of immersing the first electroformed member in an electrolyte to which particles of a certain grain size are added, to form a second electroformed member including a plurality of projections on the external peripheral surface of the first electroformed member;   a step of cutting the first electroformed member and the second electroformed member into a predetermined length, to form a needle including a needle distal portion in an acute-angled shape; and   a step of extracting the core material from the cut first electroformed member.       
 
         [0021]    In the method for manufacturing the needle, the method for manufacturing the needle comprises:
       a step of applying a masking agent at predetermined intervals on the external peripheral surface of the first electroformed member along the longitudinal direction of the first electroformed member, after the first electroformed member is formed, wherein   in the step of forming the second electroformed member, the second electroformed member is formed on the external peripheral surface of the first electroformed member on which the masking agent is not applied, and   in the step of cutting the first electroformed member and the second electroformed member, cutting is performed in a region where only the first electroformed member is formed, to form a needle proximal portion, and cutting is performed in a region where the second electroformed member is formed, to form a needle distal portion.       
 
         [0025]    In the method for manufacturing the needle, the electrolyte includes at least nickel sulfamate, boric acid, and nickel chloride,
       the particles includes at least one selected from the group consisting of silicon carbide, sapphire, diamond, and alumina ceramics, and   the first electroformed member and the second electroformed member are formed under electroforming conditions that a current is 1 to 3 A, a voltage is 1 to 3 V, a temperature of the electrolyte is 45 to 70° C., and an energization time is 1 to 20 minutes.       
 
         [0028]    In the method for manufacturing the needle, the energization time to form the first electroformed member is set longer than the energization time to form the second electroformed member. 
         [0029]    In the method for manufacturing the needle, the projections have intervals of 0.2 to 100 μm between adjacent top portions thereof, and heights of 0.1 to 50 μm from an external peripheral surface of the second electroformed member. 
         [0030]    In the method for manufacturing the needle, the tapered shape is a curved shape along the longitudinal direction. 
         [0031]    In the method for manufacturing the needle, the tapered shape is a straight shape along the longitudinal direction. 
         [0032]    In the method for manufacturing the needle, the needle is an injection needle. 
       Effects of the Invention 
       [0033]    The needle according to the present invention includes projections having intervals of 0.2 to 100 μm between top portions thereof and a height of 0.1 to 50 μm from the external peripheral surface. With this structure, when the living body is punctured with the needle, because the projections push the skin of the living body, there is a lower probability that the needle contacts the pain spots, and hence pain is reduced. 
         [0034]    In addition, according to a method for manufacturing the needle of the present invention, the external peripheral surface of the needle tube is formed in a tapered shape along the longitudinal direction, and the flow resistance in injection of a liquid medicine into the needle tube is reduced. Besides, the needle tube is formed using an electrolyte with added particles of a certain particle size. This structure enables manufacturing of the needle having projections that reduce pain on the external peripheral surface at low cost with high accuracy. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0035]      FIG. 1A  is a perspective view of a needle according to a present embodiment, and  FIG. 1B  is a cross-sectional view taken along line IB-IB of  FIG. 1A . 
           [0036]      FIG. 2  is a block diagram illustrating a manufacturing system for manufacturing the needle of the present embodiment. 
           [0037]      FIG. 3  is a flow chart illustrating a method for manufacturing the needle according to the present embodiment. 
           [0038]      FIG. 4  is a side view of a core material used for manufacturing the needle according to the present embodiment. 
           [0039]      FIG. 5A  and  FIG. 5B  are explanatory drawings illustrating a manufacturing step and a masking step for a first electroformed member in the present embodiment. 
           [0040]      FIG. 6A  to  FIG. 6C  are explanatory drawings of steps from a manufacturing step for a second electroformed member to a manufacturing step for the needle according to the present embodiment. 
           [0041]      FIG. 7A  is a side view of a core material used for manufacturing a needle according to another embodiment, and  FIG. 7B  is a perspective view of the needle manufactured by using the core material of  FIG. 7A . 
       
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Structure of Needle 
       [0042]      FIG. 1A  is a perspective view of a needle  10  according to the present embodiment, and  FIG. 1B  is a cross-sectional view taken along line IB-IB of  FIG. 1A . In the present embodiment, the needle  10  is an injection needle that injects a liquid medicine into the living body. 
         [0043]    The needle  10  includes a needle tube  12  having a tapered shape and formed by electroforming. The needle tube  12  is provided with a passage  14  having a circular cross section and through which a liquid medicine passes. The needle tube  12  includes a needle distal portion  16  and a needle proximal portion  18 . The needle distal portion  16  includes a puncture surface  20  that is cut in an acute-angled shape and a liquid medicine outlet  22 . The needle proximal portion  18  includes a liquid medicine injection port  24  that is cut perpendicularly to the axis of the needle tube  12 . An internal peripheral surface  26  of the needle distal portion  16  has a curved and tapered shape along the longitudinal direction of the needle tube  12 . A diameter d of the passage  14  gradually increases from the liquid medicine outlet  22  toward the liquid medicine injection port  24 . In the same manner, an external peripheral surface  28  of the needle distal portion  16  has a curved and tapered shape along the longitudinal direction of the needle tube  12 . The external peripheral surface  28  of the needle distal portion  16  is provided with a large number of projections  30 . An interval W between top portions of the adjacent projections  30  is 0.2 to 100 μm. A height H of each of the projections  30  from the external peripheral surface  28  is 0.1 to 50 μm. 
       Structure of Manufacturing System 
       [0044]      FIG. 2  is a block diagram of a manufacturing system  100  for manufacturing the needle  10  of the present embodiment.  FIG. 3  is a flow chart illustrating a method for manufacturing the needle  10  according to the present embodiment.  FIG. 4  is a side view of a core material  122  used for manufacturing the needle  10  according to the present embodiment.  FIG. 5A  and  FIG. 5B  are explanatory drawings illustrating a manufacturing step and a masking step for a first electroformed member in the present embodiment.  FIG. 6A  to  FIG. 6C  are explanatory drawings of steps from a manufacturing step for a second electroformed member to a manufacturing step for the needle according to the present embodiment. 
         [0045]    The manufacturing system  100  includes a plating device  104 , a first electroforming device  106 , a masking device  108 , a second electroforming device  110 , a removal device  112 , a laser processing device  114 , an extracting device  116 , a plating device  118 , and a molding device  120 . 
         [0046]    The plating device  104  deposits gold on an external peripheral surface  124  of the core material  122  forming the passage  14  of the needle tube  12 , to plate the external peripheral surface  124  with gold. The first electroforming device  106  forms a first electroformed member  126  obtained by depositing nickel on the gold-plated external peripheral surface  124  of the core material  122 . The masking device  108  applies a masking agent  130  at predetermined intervals on an external peripheral surface  128  of the first electroformed member  126  along the longitudinal direction of the first electroformed member  126 . The second electroforming device  110  forms a second electroformed member  134  by depositing nickel on a part of the external peripheral surface  128  of the first electroformed member  126  on which the masking agent  130  is not applied. The second electroformed member  134  includes the projections  30 . The removal device  112  removes the masking agent  130  from the external peripheral surface  128  of the first electroformed member  126 . The laser processing device  114  irradiates the first electroformed member  126  and the second electroformed member  134  with a laser beam, to cut the first electroformed member  126  and the second electroformed member  134  into a predetermined length and shape. The extracting device  116  extracts the core material  122  from the first electroformed member  126 . The plating device  118  deposits gold on the external peripheral surface  128  of the cut first electroformed member  126 , the external peripheral surface  136  of the cut second electroformed member  134 , and the internal peripheral surface  140  of a hollow portion  138  to perform gold plating. The molding device  120  molds a resin base  142  at the needle proximal portion  18  of the needle  10  formed of the gold-plated first electroformed member  126  and the second electroformed member  134 . 
       Method for Manufacturing Needle  10   
       [0047]    A method for manufacturing the needle  10  will be explained hereinafter with reference to  FIG. 3  to  FIG. 6 . 
         [0048]    First, a core material  122  having a shape corresponding to the passage  14  of the needle  10  is prepared ( FIG. 4 ). The shape of the external peripheral surface  124  in ranges  144  and  146  of the core material  122  is point-symmetrical with respect to the center of a cut surface  148 . The external peripheral surface  124  has a curved tapered shape along the longitudinal direction. Broken lines indicates cut surfaces  148  and  150  produced by the laser processing device  114 . The diameter d of the core material  122  gradually increases from the cut surface  148  toward the cut surfaces  150 . The core material  122  is formed of, for example, stainless. The core material  122  is immersed in a non-ferrous alkaline detergent of 50 g/L and degreased (Step S 1 ). 
         [0049]    In the plating device  104 , gold is deposited on the external peripheral surface  124  of the degreased core material  122 , and the core material  122  is plated with gold (Step S 2 ). The core material  122  is cleaned, and the plating solution is removed from the core material  122  (Step S 3 ). 
         [0050]    In the first electroforming device  106 , the gold-plated core material  122  is immersed in an electrolyte, and a first electroformed member  126  is formed on the external peripheral surface  124  of the core material  122  under certain electroforming conditions (Step S 4 ,  FIG. 5A ). 
         [0051]    The electrolyte at least includes 450 g/L of nickel sulfamate, 20 to 30 g/L of boric acid, 10 to 20 g/L of a nickel chloride, 5 to 10 cc/L of a sulfonate benzoate imide salt, and 5 to 10 cc/L of saccharin. The electrolyte may also include a sodium lauryl sulfate supersaturated solution, a hardening agent (NSF-E (Nippon Chemical Industrial Co., Ltd.)), sodium naphthalene sulfonate, acetyl cyanamide, Thiourea, and para-tluenesulfonamide. The electrolyte including these substances enables reduction in time required for electroforming. As the certain electroforming conditions, the voltage is 1 to 3 V, the current is 1 to 3 A, the energization time is 1 to 20 minutes, and the temperature of the electrolyte is 45 to 70° C. 
         [0052]    In the first electroforming device  106 , the core material  122  of a cathode is energized, and the nickel material including sulfur of an anode is energized. The nickel material including sulfur easily dissolves into the electrolyte. The nickel material is formed of, for example, nickel spheres. The nickel spheres are contained in a titanium wire netting. When a voltage of 1 to 3 V and a current of 1 to 3 A are applied between the cathode and the anode, nickel in the anode is ionized and dissolves into the electrolyte. The nickel ions in the electrolyte are deposited as nickel on the core material  122  of the cathode. As a result, the first electroformed member  126  of nickel is formed on the external peripheral surface  124  of the core material  122 . The first electroformed member  126  is cleaned, and the electrolyte is removed from the first electroformed member  126  (Step S 5 ). 
         [0053]    In the masking device  108 , the masking agent  130  is applied at predetermined intervals on the external peripheral surface  128  of the first electroformed member  126  along the longitudinal direction of the first electroformed member  126  formed on the core material  122  (Step S 6 ,  FIG. 5B ). The regions on which the masking agent  130  of the first electroformed member  126  is applied are portions corresponding to the needle proximal portion  18  of the needle  10  illustrated in  FIG. 1A  and  FIG. 1B . 
         [0054]    In the second electroforming device  110 , an electrolyte is prepared by including particles of a certain grain size in the electrolyte of the first electroforming device  106 . The electrolyte of the second electroforming device  110  may include a sodium lauryl sulfate supersaturated solution, a hardening agent (NSF-E (Nippon Chemical Industrial Co., Ltd.)), sodium naphthalene sulfonate, acetyl cyanamide, Thiourea, and para-tluenesulfonamide. In the same manner as in Step S 4 , the electrolyte including these substances enables reduction in time required for electroforming. The particles included in the electrolyte includes at least one selected from the group consisting of silicon carbide, sapphire, diamond, and alumina ceramics. The grain size of the particles is 0.2 to 100 μm. The concentration of the particles in the electrolyte is, for example, approximately 10 g/L in the case of sapphire. 
         [0055]    In the second electroforming device  110 , the first electroformed member  126  with the applied masking agent  130  is immersed in the electrolyte, and the second electroformed member  134  is formed on the part of the external peripheral surface  128  of the first electroformed member  126  that is not masked, under certain electroforming conditions (Step S 7 ,  FIG. 6A ). As the certain electroforming conditions, the voltage is 1 to 3 V, the current is 1 to 3 A, the energization time is 1 to 20 minutes, and the temperature of the electrolyte is 45 to 70° C. The energization time is set shorter than the energization time for forming the first electroformed member  126 . Accordingly, the second electroformed member  134  is formed with a thickness smaller than the thickness of the first electroformed member  126 , and with a shorter time. 
         [0056]    The cathode and the anode of the second electroforming device  110  are formed in the same manner as the cathode and the anode of the first electroforming device  106 . When a current of 1 to 3 A with a voltage of 1 to 3 V is applied between the cathode and the anode, nickel in the anode is ionized and dissolves into the electrolyte. The nickel ions in the electrolyte are deposited as nickel on the first electroformed member  126  of the cathode. As a result, the second electroformed member  134  of nickel including the particles is formed on the part of the external peripheral surface  128  of the first electroformed member  126  on which the masking agent  130  is not applied. The projections  30  of the particles included in the electrolyte is formed on the external peripheral surface  136  of the second electroformed member  134 . No second electroformed member  134  is formed on the external peripheral surface  128  of the first electroformed member  126  with the applied masking agent  130 . The second electroformed member  134  is cleaned, and the electrolyte is removed from the second electroformed member  134  (Step S 8 ). 
         [0057]    The interval W between the top portions of the adjacent projections  30  formed on the external peripheral surface  136  of the second electroformed member  134  is easily controlled according to the concentration of the particles included in the electrolyte and the energization time. In addition, the height H of the projections  30  from the external peripheral surface  136  (corresponding to the external peripheral surface  28  of the needle  10 ) of the second electroformed member  134  is easily controlled according to the grain size of the particles included in the electrolyte. The external peripheral surface  136  of the second electroformed member  134  is provided with projections  30  with the interval W of 0.2 to 100 μm and the height H of 0.1 to 50 μm. 
         [0058]    In the removal device  112 , the masking agent  130  applied in Step S 6  is removed from the external peripheral surface  128  of the first electroformed member  126  (Step S 9 ). 
         [0059]    In the laser processing device  114 , the first electroformed member  126  and the second electroformed member  134  are cut into a predetermined length and shape, in accordance with the size (length) of the needle  10  and the shape of the puncture surface  20  (Step S 10 ,  FIG. 6B ). Specifically, in the laser processing device  114 , the cut surface  148  in the center of the second electroformed member  134  provided with the projections  30  is formed in an acute-angled shape, in accordance with the shape of the puncture surface  20  of the needle  10 . In addition, in the laser processing device  114 , the cut surface  150  in the center of the first electroformed member  126  without the projections  30  is formed at right angles to agree with the shape of the liquid medicine injection port  24 . 
         [0060]    In the extracting device  116 , the core material  122  is extracted from the first electroforming member  126  (Step S 11 ). Extraction of the core material  122  forms a hollow portion  138  corresponding to the passage  14  of the needle  10  ( FIG. 6C ). 
         [0061]    In the plating device  118 , gold plating is performed on the external peripheral surface  128  of the first electroformed member  126 , the external peripheral surface  136  of the second electroformed member  134 , the internal peripheral surface  140  of the hollow portion  138 , and the cut surfaces  148  and  150  (Step S 12 ). The first electroformed member  126  and the second electroformed member  134  are subjected to cleaning, and the plating solution is removed therefrom (Step S 13 ), to obtain the needle  10 . The main reason for plating the first electroformed member  126  and the second electroformed member  134  with gold is to prevent an allergic reaction in the living body to the nickel forming the needle  10 . 
         [0062]    In the molding device  120 , the base  142  formed of resin is formed as one unitary piece with the needle proximal portion  18  of the needle  10  (Step S 14 ,  FIG. 6C ). In this case, no projections  30  are formed on the external peripheral surface  128  of the first electroformed member  126  serving as the needle proximal portion  18 . Accordingly, the base  142  is in close contact with the external peripheral surface  128  of the first electroformed member  126 . The base  142  integrated with the needle  10  is attached to an injection needle main body  152  that supplies liquid medicine. 
         [0063]      FIG. 7A  is a side view of a core material  156  used for manufacturing a needle  164  according to another embodiment, and  FIG. 7B  is a perspective view of the needle  164  manufactured from the core material  156  of  FIG. 7A . 
         [0064]    The shape of the external peripheral surface  162  in ranges  158  and  160  of the core material  156  is point-symmetrical with respect to the center of the cut surface  148 . The external peripheral surface  162  has a straight tapered shape along the longitudinal direction. 
         [0065]    The needle  164  is manufactured using the core material  156 , in the same manner as the needle  10 . In this case, a passage  168  formed in a needle tube  166  of the needle  164  has a straight tapered shape with a diameter gradually increasing from a needle distal portion  170  toward a needle proximal portion  172 . In the same manner, an external peripheral surface  174  of the needle tube  166  has a straight tapered shape with a diameter gradually increasing from the needle distal portion  170  toward the needle proximal portion  172 . The external peripheral surface  174  of the needle distal portion  170  is provided with a large number of projections  176 , in the same manner as the needle  10 . 
         [0066]    Because the needles  10  and  164  manufactured as described above are provided with the projections  30  and  176  on the external peripheral surfaces  28  and  174 , respectively, for example, when the living body is punctured with the needle  10  or  164 , the projections  30  or  176  push the skin of the living body. This structure markedly reduces the probability that the external peripheral surface  28  or  174  contact pain spots. As a result, pain spots are only slightly stimulated by the projections  30  or  176 , and this structure markedly reduces pain caused by puncture. In addition, the passages  14  and  168  of the needles  10  and  164  have a curved or straight tapered shape with a diameter gradually increasing from the needle distal portions  16  and  170  toward the needle proximal portions  18  and  172 . This structure reduces flow resistance when a liquid medicine is injected into the living body from the needle distal portions  16  and  170 . The electroforming step is divided into a step of forming the first electroformed member  126  using an electrolyte including no particles, and a step of forming the second electroformed member  134  using an electrolyte including particles. Accordingly, no projections  30  and  176  are formed on the internal peripheral surfaces  140  of the first electroformed members  126  serving as the passages  14  and  168  of the needles  10  and  164 , respectively. Consequently, a liquid medicine can be smoothly injected into the passages  14  and  168 . In addition, because the needles  10  and  164  are obtained by cutting the first electroformed member  126  and the second electroformed member  134  into ones of predetermined lengths, a large number of needles  10  and  164  can be manufactured in a short time. 
         [0067]    The present invention is not limited to the above embodiments, but can be varied within a range not departing from the gist of the present invention. 
         [0068]    The needles  10  and  164  are explained as injection needles in the present embodiment, but the present invention is not limited thereto, as long as the needle is used for puncturing the living body. For example, the needle may be a sampling needle to sample a body fluid from the living body. 
         [0069]    The manufacturing process of the present embodiment is a process in which, after the first electroformed member  126  is formed, the masking agent  130  is applied, and thereafter the second electroformed member  134  is formed, but the present invention is not limited thereto, as long as the needle  10  or  164  including the projections  30  or  176  can be formed. For example, as a modification of the manufacturing process, the step of applying the masking agent  130  may be omitted, and, after the first electroformed member  126  is formed, the second electroformed member  134  may be formed on the whole external peripheral surface  128  of the first electroformed member  126 . The needle  10  or  164  formed as described above has a structure in which the projections  30  or  176  are formed on the whole external peripheral surface  28 , and the base  142  is formed at the needle proximal portion  18  or  172  including the projections  30  or  176 . 
       KEY TO SYMBOL 
       [0070]      10 , 164 : needle 
         [0071]      12 , 166 : needle tube 
         [0072]      14 , 168 : passage 
         [0073]      16 , 170 : needle distal portion 
         [0074]      18 , 172 : needle proximal portion 
         [0075]      20 : puncture surface 
         [0076]      22 : liquid medicine outlet 
         [0077]      24 : liquid medicine injection port 
         [0078]      26 , 140 : internal peripheral surface 
         [0079]      28 , 124 , 128 , 136 , 162 , 174 : external peripheral surface 
         [0080]      30 , 176 : projection 
         [0081]      100 : manufacturing system 
         [0082]      104 , 118 : plating device 
         [0083]      106 : first electroforming device 
         [0084]      108 : masking device 
         [0085]      110 : second electroforming device 
         [0086]      112 : removal device 
         [0087]      114 : laser processing device 
         [0088]      116 : extracting device 
         [0089]      120 : molding device 
         [0090]      122 , 156 : core material 
         [0091]      126 : first electroformed member 
         [0092]      130 : masking agent 
         [0093]      134 : second electroformed member 
         [0094]      138 : hollow portion 
         [0095]      142 : base 
         [0096]      144 , 146 , 158 , 160 : range 
         [0097]      148 , 150 : cut surface 
         [0098]      152 : injection needle main body