Abstract:
This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

Description:
FIELD OF THE INVENTION 
     This invention generally relates to the derivatives of novel 3,6-disubstituted azabicyclo[3.1.0]hexanes. 
     The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. 
     The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors. 
     BACKGROUND OF THE INVENTION 
     Muscarinic receptors as members of the G Protein Coupled Receptors (GPCRS) are composed of a family of 5 receptor sub-types (M 1 , M 2 , M 3 , M 4  and M 5 ) and are activated by the neurotransmitter acetylcholine. These receptors are widely distributed on multiple organs and tissues and are critical to the maintenance of central and peripheral cholinergic neurotransmission. The regional distribution of these receptor sub-types in the brain and other organs has been documented. For example, the M 1  subtype is located primarily in neuronal tissues such as cereberal cortex and autonomic ganglia, the M 2  subtype is present mainly in the heart where it mediates cholinergically induced bradycardia, and the M 3  subtype is located predominantly on smooth muscle and salivary glands ( Nature , 1986; 323: 411; Science, 1987; 237: 527). 
     A review in Current opinions in Chemical Biology, 1999; 3: 426, as well as in Trends in Pharmacological Sciences, 2001; 22: 409 by Eglen et. al., describe the biological potentials of modulating muscarinic receptor subtypes by ligands in different disease conditions like Alzheimer&#39;s disease, pain, urinary disease condition, chronic obstructive pulmonary disease etc. 
     A review in J. Med. Chem., 2000; 43: 4333 by Christian C. Felder et. al. describes therapeutic opportunities for muscarinic receptors in the central nervous system and elaborates on muscarinic receptor structure and function, pharmacology and their therapeutic uses. 
     The pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists are presented in a review in Molecules, 2001, 6: 142. 
     N. J. M. Birdsall et. al. in Trends in Pharmacological Sciences, 2001; 22: 215 have also summarized the recent developments on the role of different muscarinic receptor subtypes using different muscaranic receptor of knock out mice. 
     Muscarinic agonists such as muscarine and pilocarpine and antagonists such as atropine have been known for over a century, but little progress has been made in the discovery of receptor subtype-selective compounds making it difficult to assign specific functions to the individual receptors. Although classical muscarinic antagonists such as atropine are potent bronchodilators, their clinical utility is limited due to high incidence of both peripheral and central adverse effects such as tachycardia, blurred vision, dryness of mouth, constipation, dementia, etc. Subsequent development of the quarterly derivatives of atropine such as ipratropium bromide are better tolerated than parenterally administered options but most of them are not ideal anti-cholinergic bronchodilators due to lack of selectivity for muscarinic receptor sub-types. The existing compounds offer limited therapeutic benefit due to their lack of selectivity resulting in dose limiting side-effects such as thirst, nausea, mydriasis and those associated with the heart such as tachycardia mediated by the M 2  receptor. 
     Annual review of Pharmacological Toxicol., 2001; 41: 691, describes the pharmacology of the lower urinary tract infections. Although anti muscarinic agents such as oxybutynin and tolterodine that act non-selectively on muscarinic receptors have been used for many years to treat bladder hyperactivity, the clinical effectiveness of these agents has been limited due to the side effects such as dry mouth, blurred vision and constipation. Tolterodine is considered to be generally better tolerated than oxybutynin. (W. D. Steers et. al. in Curr. Opin. Invest. Drugs, 2: 268, C. R. Chapple et. al. in Urology, 55: 33), Steers W D, Barrot D M, Wein A J, 1996, Voiding dysfunction: diagnosis classification and management. In Adult and Pediatric Urology, ed. J Y Gillenwatter, J T Grayhack, S S Howards, J W Duckett, pp 1220-1325, St. Louis, Mo.; Mosby. 3 rd  edition.) 
     Despite these advances, there remains a need for development of new highly selective muscarinic antagonists which can interact with distinct subtypes, thus avoiding the occurrence of adverse effects. 
     Compounds having antagonistic activity against muscarinic receptors have been described in Japanese patent application Laid. Open Number 92921/1994 and 135958/1994; WO 93/16048; U.S. Pat. No. 3,176,019; GB 940,540; EP 0325 571; WO 98/29402; EP 0801067; EP 0388054; WO 9109013; U.S. Pat. No. 5,281,601. U.S. Pat. Nos. 6,174,900, 6,130,232 and 5,948,792; WO 97/45414 are related to 1,4-disubstituted piperidine derivatives; WO 98/05641 describes fluorinated, 1,4-disubstitued piperidine derivatives; WO 93/16018 and WO96/33973 are other close art references. 
     A report in J. Med. Chem., 2002; 44:984, describes cyclohexylmethyl piperidinyl triphenylpropioamide derivatives as selective M 3  antagonist discriminating against the other receptor subtypes. 
     SUMMARY OF THE INVENTION 
     The present invention provides novel 3,6-disubstituted azabicyclo[3.1.0]hexanes as muscarinic receptor antagonists which are useful as safe and effective therapeutic or prophylactic agents for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems, and process for the synthesis of the novel compounds. 
     The invention also provides pharmaceutical compositions containing the novel compounds together with acceptable carriers, excipients or diluents which are useful for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems. 
     The present invention also includes within its scope prodrugs of the novel compounds. In general, such prodrugs will be functionalized derivatives of these compounds which readily get converted in vivo into the defined compounds. Conventional procedures for the selection and preparation of suitable prodrugs are known to the artisan skilled in the art. 
     The invention also includes the enantiomers, diastereomers, N-oxides, polymorphs, pharmaceutically acceptable salts and pharmaceutically acceptable solvates of these compounds as well as metabolites having the same type of activity. 
     The invention further includes pharmaceutical compositions comprising the compounds of the present invention, their prodrugs, metabolites, enantiomers, diastereomers, N-oxides, polymorphs, solvates or pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable carrier and optionally included excipients. 
     Other advantages of the invention will be set forth in the description which follows, and in part will be apparent from the description or may be learnt by the practice of the invention. The objects and the advantages of the invention may be realized and obtained by means of the mechanisms and combinations pointed out in the appended claims. 
     In accordance with one aspect of the present invention, there is provided a compound having the structure of Formula I: 
                                
and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, prodrugs, metabolites, wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) amino or N-lower alkyl (C 1 -C 4 ) amino carbonyl;
     R 1  represents a hydrogen, hydroxy, hydroxy methyl, amino, alkoxy, carbamoyl or halogen (e.g. fluorine, chlorine, bromine and iodine);   R 2  represents aLkyl, C 3 -C 7  cycloalkyl ring, a C 3 -C 7  cyclo alkenyl ring, an aryl or a heteroaryl ring having 1 to 2 hetero atoms selected from a group consisting of oxygen, sulphur and nitrogen atoms; the aryl or a heteroaryl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ), N-lower alkylamino carbonyl (C 1 -C 4 );   W represents (CH 2 ) p , where p represents 0 to 1;   X represents an oxygen, sulphur, nitrogen or no atom;   Y represents CHR 5 CO wherein R 5  represents hydrogen or methyl or (CH 2 )q wherein q represents 0 to 4;   Z represents oxygen, sulphur, NR 10 , wherein R 10  represents hydrogen, C 1-6  alkyl;   Q represents (CH 2 ) n  wherein n represents 0 to 4, or CHR 8  wherein R 8  represents H, OH, C 1-6 , alkyl, alkenyl alkoxy or CH 2 CHR 9  wherein R 9  represents H, OH, lower alkyl (C 1 -C 4 ) or lower alkoxy (C 1 -C 4 );   R 6  and R 7  are independently selected from COOH, H, CH 3 , CONH 2 , NH 2 , CH 2 NH 2 ;   R 4  represents C 1 -C 15  saturated or unsaturated aliphatic hydrocarbon groups in which any 1 to 6 hydrogen atoms may be substituted with the group independently selected from halogen, arylalkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl having 1 to 2 hetero atoms selected from a group consisting of nitrogen, oxygen and sulphur atoms with option that any 1 to 3 hydrogen atoms on the ring in said arylalkyl, arylalkenyl, hetero arylalkenyl group may be substituted with lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxyl, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhaloalkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ), N-lower alkylamino carbonyl (C 1 -C 4 ).   
     In accordance with a second aspect of the present invention, there is provided a compound having the structure of Formula II (Formula I, when R 6  and R 7 ═H) and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, prodrugs, metabolites, wherein Ar, R 1 , R 2 , W, X, Y, Z, Q, and R 4  are as defined for Formula I. 
     
       
                 
         
             
             
         
      
     
     In accordance with a third aspect of the present invention, there is provided a compound having the structure of Formula III (Formula I wherein W is (CH 2 )p where p=0, X is no atom and Y is (CH 2 )q where q=0, R 6 ═H, R 7 ═H) and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, prodrugs, metabolites, wherein Ar, R 1 , R 2 , Z, Q and R 4  are as defined for Formula I. 
     
       
                 
         
             
             
         
      
     
     In accordance with a fourth aspect of the present invention, there is provided a compound having the structure of Formula IV (Formula I wherein W is (CH 2 )p where p=0, X is no atom and Y is (CH 2 )q where q=0, R 6 ═H, R 7 ═H, 
                                
and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, prodrugs, metabolites, wherein Ar, R 1 , Z, Q and R 4  are as defined for Formula I and r is 1 to 4.
 
     
       
                 
         
             
             
         
      
     
     In accordance with a fifth aspect of the present invention, there is provided a compound having the structure of Formula V (Formula I wherein W is (CH 2 )p where p=0, X is no atom and Y is (CH 2 )q where q=0, R 6 ═H, R 7 ═H, 
                                
R 1  is hydroxy, Ar is phenyl), and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, esters, enantiomers, diastereomers, N-oxides, polymorphs, prodrugs, metabolites, wherein R 4 , Z and Q are the same as defined for Formula I, s represents 1 to 2.
 
     
       
                 
         
             
             
         
      
     
     In accordance with a sixth aspect of the present invention, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder of the respiratory, urinary and gastrointestinal systems, wherein the disease or disorder is mediated through muscarinic receptors. 
     In accordance with a seventh aspect of the present invention, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder associated with muscarinic receptors, comprising administering to a patient in need thereof, an effective amount for muscarinic receptor antagonist compound as described above. 
     In accordance with an eighth aspect of the present invention, there is provided a method for treatment or prophylaxis of an animal or a human suffering from a disease or disorder of the respiratory system such as bronchial asthma, chronic obstructive pulmonary disorders (COPD), pulmonary fibrosis, etc.; urinary system which induce such urinary disorders as urinary incontinence, lower urinary tract symptoms (LUTS), etc.; and gastrointestinal system such as irritable bowel syndrome, obesity, diabetes and gastrointestinal hyperkinesis with compounds as described above, wherein the disease or disorder is associated with muscarinic receptors. 
     In accordance with a ninth aspect of the present invention, there are provided processes for preparing the compounds as described above. 
     The compounds of the present invention are novel and exhibit significant potency in terms of their activity, which was determined by in vitro receptor binding and functional assays and in vivo experiments using anaesthetized rabbit. The compounds that were found active in in vitro assay were tested in vivo. Some of the compounds of the present invention were found to be potent muscarinic receptor antagonists with high affinity towards M 3  receptors. Therefore, the present invention provides the pharmaceutical compositions for the possible treatment for the disease or disorders associated with muscarinic receptors. In addition, the compounds of the present invention can be administered orally or parenterally. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The compounds of the present invention may be prepared by techniques well known in the art and familiar to the average synthetic organic chemist. In addition, the compounds of the present invention may be prepared by the following novel and inventive reaction sequences: 
     
       
                 
         
             
             
         
      
     
     The compounds of Formula I of the present invention may be prepared by the reaction sequence as shown in Scheme I. The preparation comprises condensing a compound of Formula VII with the compound of Formula VI wherein Ar represents an aryl or a heteroaryl ring having 1-2 hetero atoms selected from the group consisting of oxygen, sulphur and nitrogen atoms, the aryl or heteroaryl rings may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkyl (C 1 -C 4 ) amino or N-lower alkyl (C 1 -C 4 ) amino carbonyl;
     R 1  represents a hydrogen, hydroxy, hydroxy methyl, amino, alkoxy, carbamoyl or halogen (e.g. fluorine, chlorine, bromine and iodine);   R 2  represents alkyl, C 3 -C 7  cycloalkyl ring, a C 3 -C 7  cyclo alkenyl ring, an aryl or a heteroaryl ring having 1 to 2 hetero atoms selected from a group consisting of oxygen, sulphur and nitrogen atoms; the aryl or a heteroaryl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl (C 1 -C 4 ), lower perhalo alkyl (C 1 -C 4 ), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C 1 -C 4 ), lower perhalo alkoxy (C 1 -C 4 ), unsubstituted amino, N-lower alkylamino (C 1 -C 4 ), N-lower alkylamino carbonyl (C 1 -C 4 );   W represents (CH 2 ) p , where p represents 0 to 1;   X represents an oxygen, sulphur, nitrogen or no atom;   Y represents CHR 5 CO wherein R 5  represents hydrogen or methyl or (CH 2 )q wherein q represents 0 to 4;   Z represents oxygen, sulphur, NR 10 , wherein R 10  represents hydrogen, C 1-6 alkyl;   Q represents (CH 2 ) n  wherein n represents 0 to 4, or CHR 8  wherein R 8  represents H, OH, C 1-6 , alkyl, alkenyl alkoxy or CH 2 CHR 9  wherein R 9  represents H, OH, lower alkyl (C 1 -C 4 ) or lower alkoxy (C 1 -C 4 );   R 6  and R 7  are independently selected from COOH, H, CH 3 , CONH 2 , NH 2 , CH 2 NH 2 ;   P is any protecting group for an amino group, in the presence of a condensing agent to give a protected compound of Formula VIII which on deprotection in the presence of a deprotecting agent in an organic solvent gives an unprotected intermediate of Formula IX which is finally N-alkylated or benzylated with a suitable alkylating or benzylating agent L-R 4  to give a compound of Formula I wherein L is any leaving group and R 4  is as defined above.   P is any protecting group for an amino group for a compound of Formula VI and is selected from benzyl and t-butyloxy carbonyl groups.   

     The reaction of the compound of Formula VII with a compound of Formula VI to give a compound of Formula VIII is carried out in the presence of a condensing agent which is selected from the group consisting of 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDC) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). 
     The reaction of the compound of Formula VII with a compound of Formula VI to give a compound of Formula VIII is carried out in a suitable solvent selected from the group consisting of N,N-dimethylformamide, dimethylsulfoxide, toluene, and xylene at a temperature ranging from about 0-140° C. 
     The deprotection of the compound of Formula VIII to give a compound of Formula IX is carried out with a deprotecting agent which is selected from the group consisting of palladium on carbon, trifluoroacetic acid (TFA) and hydrochloric acid. 
     The deprotection of the compound of Formula VIII to give a compound of Formula IX is carried out in a suitable organic solvent selected from the group consisting of methanol, ethanol, tetrahydrofuran and acetonitrile at temperatures ranging from about 10-50° C. 
     The N-alkylation or benzylation of the compound of Formula IX to give a compound of Formula I is carried out with a suitable alkylating or benzylating agent, L-R 4  wherein L is any leaving group, known in the art, preferably selected from halogen, O-mestyl and O-tosyl group. 
     The N-alkylation or benzylation of the compound of Formula IX to give a compound of Formula I is carried out in a suitable organic solvent such as N,N-dimethylformamide, dimethyl sulfoxide, tetrahydrofuran and acetonitrile, at temperatures ranging from about 25-100° C. 
     In the above scheme, where specific bases, condensing agents, protecting groups, deprotecting agents, N-alkylating/benzylating agents, solvents, catalysts etc. are mentioned, it is to be understood that other bases, condensing agents, protecting groups, deprotecting agents, N-alkylating/benzylating agents, solvents, catalysts etc. known to those skilled in the art may be used. Similarly, the reaction temperature and duration may be adjusted according to the desired needs. 
     Alternatively, the compounds of the invention may be prepared by condensing compounds of formula VI with an aryl alpha keto ester (Ar(CO)COOR′ wherin R′ denotes a lower alkyl group) and the compounds thus formed may be subsequently reacted with the condensate R″M, wherein R″ groups include groups such as phenyl, C4-6 alkyl etc. and M may be alkali metal or MgX, wherein x is a halogen atom. Alpha keto esters may in turn be prepared by following J.O.C., 46, 213(1981), or synthetic communication, 11, 943(1981). 
     The compounds of the invention may also be prepared by reacting R″M (wherein M and R″ have the same as described above) with the aryl alpha keto ester (Ar(CO)COOR′ wherin R′ denotes a lower alkyl group) to form an alpha hydroxy ester. This product is further reacted with compound of formula VI and then the protecting group is removed to give compounds of formula VIII. 
     Suitable salts of the compounds represented by the Formula I were prepared so as to solubilize the compound in aqueous medium for biological evaluations. Examples of such salts include pharmacologically acceptable salts such as inorganic acid salts (e.g. hydrochloride, hydrobromide, sulphate, nitrate and phosphorate), organic acid salts(e.g. acetate, tartarate, citrate, fumarate, maleate, tolounesulphonate and methanesulphonate). When carboxyl group is included in the Formula I as a substituent, it may be an alkali metal salt(e.g. sodium, potassium, calcium, magnesium, and the like). These salts may be prepared by the usual prior art techniques, such as treating the compound with an equivalent amount of inorganic or organic, acid or base in a suitable solvent. 
     Preferred compounds according to the invention and capable of being produced by Scheme I as shown in Table-I include: 
     
       
         
               
               
             
               
               
             
           
               
                   
               
               
                 Compound 
                   
               
               
                 No. 
                 Chemical Name 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 1. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide 
               
               
                 2. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2- 
               
               
                   
                 phenyl acetamide 
               
               
                 3. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2- 
               
               
                   
                 phenyl acetamide 
               
               
                 4. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2,2-diphenyl acetate 
               
               
                 5. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 6. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetate 
               
               
                 7. 
                 (1α,5α,6α)-[3-(2-(2,3-dihydrobenzofuran- 
               
               
                   
                 5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 8. 
                 (1α,5α,6α)-[3-(2-(2,3-dihydrobenzofuran- 
               
               
                   
                 5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 9. 
                 (1α,5α,6α)-N-[3-(2-(2,3-dihydrobenzofuran- 
               
               
                   
                 5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 10. 
                 (1α,5α,6α)-N-[3-(2-(2,3-dihydrobenzofuran- 
               
               
                   
                 5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 11. 
                 (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclopentyl-2-phenyl acetate 
               
               
                 12. 
                 (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclohexyl-2-phenyl acetate 
               
               
                 13. 
                 (1α,5α,6α)-N-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 14. 
                 (1α,5α,6α)-N-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 15. 
                 (1α,5α,6α)-N-[3-(4-methyl-3-pentenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 16. 
                 (1α,5α,6α)-N-[3-(4-methyl-3-pentenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 17. 
                 (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 18. 
                 (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 19. 
                 (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 20. 
                 (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 21. 
                 (1α,5α,6α)-N-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 22. 
                 (1α,5α,6α)-N-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 23. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(1-aminoethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide 
               
               
                 24. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(1-aminoethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 25. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(1-aminoethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 26. 
                 (1α,5α,6α)-[3-(3-methyl-2-butenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 27. 
                 (1α,5α,6α)-[3-(3-methyl-2-butenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 28. 
                 (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 29. 
                 (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 30. 
                 (2R)(+)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate 
               
               
                 31. 
                 (2R)(+)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 32. 
                 (2S)-(−)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 33. 
                 (2S)-(−)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate 
               
               
                 34. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamide L-(+)-tartrate salt 
               
               
                 35. 
                 (2S)-(−)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamine. L-(+)-tartrate salt 
               
               
                 36. 
                 (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetamide. L-(+)-tartrate salt 
               
               
                 37. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclobutyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 38. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(aminomethyl)-yl]-2-hydroxy-2-cyclopropyl-2-phenyl 
               
               
                   
                 acetamide 
               
               
                 39. 
                 (1α,5α,6α)-N-[3-(3-methyl-2-butenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-hexyl-2-phenyl acetamide 
               
               
                 40. 
                 (1α,5α,6α)-[3-(3,4-methylenedioxyphenyl)methyl- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclopentyl-2-phenyl acetate 
               
               
                 41. 
                 (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclopentyl-2-phenyl acetate. L-(+)-tartrate salt 
               
               
                 42. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2,2 diphenyl acetate L(+)- 
               
               
                   
                 tartrate salt 
               
               
                 43. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl 
               
               
                   
                 acetate L(+)-tartrate salt 
               
               
                 44. 
                 (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl- 
               
               
                   
                 6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl 
               
               
                   
                 acetate L(+)-tartrate salt. 
               
               
                 45. 
                 (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 46. 
                 (1α,5α,6α)-N-[3-(4-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclohexyl-2-phenyl acetatamide 
               
               
                 47. 
                 (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 48. 
                 (1α,5α,6α)-N-[3-(4-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 49. 
                 (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2,2-diphenyl acetamide 
               
               
                 50. 
                 (1α,5α,6α)-N-[3-(4-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2,2-diphenyl acetamide 
               
               
                 51. 
                 (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2,2-diphenyl acetamide 
               
               
                 52. 
                 (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 53. 
                 (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]- 
               
               
                   
                 2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 54. 
                 (1α,5α,6α)-N-[3-(3-methyl-2-butenyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)- 
               
               
                   
                 yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 55. 
                 (1α,5α,6α)-N-[3-(3,4-methylenedioxyphenyl)methyl- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclopentyl-2-phenyl acetamide 
               
               
                 56. 
                 (1α,5α,6α)-N-[3-(3,4-methylenedioxyphenyl)methyl- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2- 
               
               
                   
                 hydroxy-2-cyclohexyl-2-phenyl acetamide 
               
               
                 57. 
                 (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2- 
               
               
                   
                 cyclohexyl-2-phenyl acetate-L-(+) tartrate salt 
               
               
                 58. 
                 (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)- 
               
               
                   
                 3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclohexyl-2-phenyl acetate. L-(+) tartrate salt 
               
               
                 59. 
                 (1α,5α,6α)-[3-(1-phenylethyl)-3- 
               
               
                   
                 azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy- 
               
               
                   
                 2-cyclopentyl-2-phenyl acetate. L-(+) tartrate salt 
               
               
                 60. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo [3.1.0]- 
               
               
                   
                 hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl- 
               
               
                   
                 2-phenyl acetamide hydrochloride salt 
               
               
                 61. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo [3.1.0]- 
               
               
                   
                 hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl- 
               
               
                   
                 2-phenyl acetamide L-(−) malic acid salt 
               
               
                 62. 
                 (1α,5α,6α)-N-[3-benzyl-3-azabicyclo [3.1.0]- 
               
               
                   
                 hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl- 
               
               
                   
                 2-phenyl acetamide maleate salt 
               
               
                   
               
             
          
         
       
     
     
       
         
               
               
             
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
               
               
             
               
               
               
               
               
               
               
             
               
               
             
               
               
               
               
               
               
               
             
               
               
             
           
               
                 TABLE I 
               
             
             
               
                   
               
               
                   
                 Formula III 
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 (Formula I, wherein W = (CH 2 )p where p = 0, X is no atom and 
               
               
                 Y = (CH 2 )q, where q = 0, R 6  = R 7  = H) 
               
             
          
           
               
                 Compound 
                   
                   
                   
                   
                   
                   
               
               
                 No. 
                 Ar 
                 R 1   
                 R 2   
                 Z 
                 Q 
                 R 4   
               
               
                   
               
             
          
           
               
                 1. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 2. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 3. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 4. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 5. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 6. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 7. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 8. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 9. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 10. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 11. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 12. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 13. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 14. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 15. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 16. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 17. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 18. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 19. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 20. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 21. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 22. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 23. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CHCH 3   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 24. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CHCH 3   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 25. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CHCH 3   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 26. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 27. 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 28 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 29 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 30 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 31 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 32 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 33 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 34 
                 L-(+) Tartaric acid salt of compound shown in Compound Number 3 in this 
               
               
                   
                 table 
               
               
                 35 
                 L-(+) Tartaric acid salt of compound shown in Compound Number 32 in 
               
               
                   
                 this table 
               
               
                 36 
                 L-(+) Tartaric acid salt of compound shown in Compound Number 29 in 
               
               
                   
                 this table 
               
               
                   
               
             
          
           
               
                 37 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 38 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 39 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 40 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 O 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 41 
                 L (+)-Tartrate salt of compound shown in Compound Number 11 of this 
               
               
                   
                 table 
               
               
                 42 
                 L (+)-Tartrate salt of compound shown in Compound Number 4 of this 
               
               
                   
                 table 
               
               
                 43 
                 L (+)-Tartrate salt of compound shown in Compound Number 5 of this 
               
               
                   
                 table 
               
               
                 44 
                 L (+)-Tartrate salt of compound shown in Compound Number 6 of this 
               
               
                   
                 table 
               
               
                   
               
             
          
           
               
                 45 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 46 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 47 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 48 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 49 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 50 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 51 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 52 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 53 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 54 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 55 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 56 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 OH 
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 NH 
                 CH 2   
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 57 
                 L-(+) Tartaric salt of compound 17 
               
               
                 58 
                 L-(+) Tartaric salt of compound 12 
               
               
                 59 
                 L-(+) Tartrate salt of compound No. 19 
               
               
                 60 
                 Hydrochloride salt of compound No. 3 
               
               
                 61 
                 L-(−) Malic acid salt of compound No. 3 
               
               
                 62 
                 Maleate salt of compound No. 3 
               
               
                   
               
             
          
         
       
     
     Because of their valuable pharmacological properties, the compounds of the present invention may be administered to an animal for treatment orally, or by parenteral route. The pharmaceutical compositions of the present invention are preferably produced and administered in dosage units, each unit containing a certain amount of at least one compound of the invention and/or at least one physiologically acceptable addition salt thereof. The dosage may be varied over extremely wide limits as the compounds are effective at low dosage levels and relatively free of toxicity. The compounds may be administered in the low micromolar concentration, which is therapeutically effective, and the dosage may be increased as desired up to the maximum dosage tolerated by the patient. 
     The present invention also includes within its scope prodrugs of the compounds of Formulae I, II, III, IV and V. In general, such prodrugs will be functional derivatives of these compounds, which readily are converted in vivo into the defined compounds. Conventional procedures for the selection and preparation of suitable prodrugs are known. 
     The present invention also includes the enantiomers, diastereomers, N-Oxides, polymorphs, solvates and pharmaceutically acceptable salts of these compounds as well as metabolites having the same type of activity. The present invention further includes pharmaceutical composition comprising the molecules of Formulae I, II, III, IV and V or prodrugs, metabolites, enantiomers, diastereomers, N-oxides, polymorphs, solvates or pharmaceutically acceptable salts thereof, in combination with pharmaceutically acceptable carrier and optionally included excipient. 
     The examples mentioned below demonstrate the general synthetic procedure as well as the specific preparation of the preferred compound. The examples are provided to illustrate the details of the invention and should not be constrained to limit the scope of the present invention. 
     Experimental Details 
     Various solvents, such as acetone, methanol, pyridine, ether, tetrahydrofuran, hexanes, and dichloromethane, were dried using various drying reagents according to the procedure described in the literature. IR spectra were recorded as nujol mulls or a thin neat film on a Perkin Elmer Paragon instrument, Nuclear Magnetic Resonance (NMR) were recorded on a Varian XL-300 MHz instrument using tetramethylsilane as an internal standard. 
     EXAMPLE 1 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide (Compound No. 1) 
     Step a: Preparation of 2-hydroxy-2,2-diphenyl acetic acid 
     Synthesized as per reported procedures in Vogel&#39;s textbook of practical organic chemistry page 1046 (5 th  Ed);  J. Am. Chem. Soc ., 75, 2654(1953) and EP 613232. 
     Step b: Preparation of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane 
     Synthesized as per reported procedures described in EP 0 413 455; U.S. Pat. No. 2,490,714 and Synlett, 1097-1102 (1996). 
     Step c: To a solution of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane (1 mmol, 0.202 gm) in dimethyl formamide, DMF (5 ml) was added 2-hydroxy-2,2-diphenyl acetic acid (1 mmol, 0.225 gm) and cooled to 0° C. The reaction mixture was treated with hydroxy benzotriazole (1 mmol, 0.135 g) followed by N-methyl morpholine (2 mmol, 0.202 gm) and stirred at 0° C. for 0.5 hrs. EDC (1-[3-(dimethylamino)propyl]-3-ethyl carbodiimide hydrochloride (1 mmol, 0.192 gms) was added and the reaction mixture (RM) was stirred at 0° C. for 1 hour and at room temperature (RT) overnight. The RM was then poured into cold water and extracted with ethyl acetate. The combined organic layers were washed with water and dried over sodium sulphate. The crude compound obtained after removing the solvent was purified by column chromatography (silicagel 100-200 mesh), eluting the compound with 30-70 ethyl acetate-hexane mixture. 
       1 H-NMR (CDCl 3 ) δ—values:7.47-7.17 (m, arom, 15H), 3.58 (s, 2H, benzylic), 3.18-3.14 (t, 2H), 2.95-2.92 (d, 2H), 2.35-2.32 (m, 2H ), 2.04 (s, 1H) 1.28-1.23 (m, 1H), 0.94-0.91 (m, 2H) 
     IR (DCM): 1658 cm −1  (amide carbonyl) 
     EXAMPLE 2 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 2) 
     Step a: Preparation of 2-hydroxy-2-cyclohexyl phenyl acetic acid: 
     This was prepared following the procedure described in J. Amer. Chem. Soc. 75, 2654 (1953). 
     Step b: Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide 
     To a solution of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane (1 mmol, 0.202 gm) in dimethyl formamide (5 ml) was added 2-hydroxy-2-cyclohexyl-2-phenylacetic acid (1 mmol, 0.234 gm) and cooled to 0° C. The reaction mixture was treated with hydroxy benzotriazole (1 mmol, 0.135 g) followed by N-methyl morpholine (2 mmol, 0.202 gm) and stirred at 0° C. for 0.5 hours. EDC (1 mmol, 0.192 gm) was then added. The reaction mixture (RM) after being stirred at 0° C. for 1 hour was later stirred at RT overnight. The RM was poured into cold water and extracted with ethyl acetate. The organic layer was dried and the crude product obtained after removing the solvent was purified by column chromatography (Silicagel 100-200 mesh) eluting the compound with 30-70 ethyl acetate-hexane mixture. 
       1 H-NMR: (CDCl 3 ) δ—values: 7.61-7.11 (m, 10H), 3.55 (s, 2H), 2.92-2.88 (m, 4H), 2.32-2.29 (m, 2H), 1.37-1.16 (m, 14H) 
     IR (DCM):1653 cm −1    
     EXAMPLE 3 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 3) 
     Step a: Preparation of 2-hydroxy-2-cyclopentyl phenyl acetic acid: 
     This was prepared following the procedure described in J. Amer. Chem. Soc. 75, 2654 (1953). 
     Step b: Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
     To a solution of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane (29.9 mmol, 6.05 gm) in dimethyl formamide (100 ml) was added 2-hydroxy-2-cyclopentyl-2-phenyl acetic acid (27.2 mmol, 6.0 gm) and cooled to 0° C. The reaction mixture was treated with hydroxy benzotriazole (29.9 mmol, 4.04 gm) followed by N-methyl morpholine (54.4 mmol, 5.2 gm) and was stirred at 0° C. for 0.5 hrs. The reaction mixture was poured into saturated bicarbonate solution and extracted with ethyl acetate. The organic layers were washed with water and dried over sodium sulphate and concentrated under reduced pressure. The residue was purified by column chromatography (silicagel 100-200 mesh) eluting compound with 20-80 to 25-75 ethyl acetate-hexane mixture. It gave a compound in 93-95% purity. To obtain higher purity (about 99%) of the compound it was triturated with toluene and filtered. 
       1 H-NMR: (CDCl 3 ) δ—values: 7.61-7.23 (m, 10H), 6.45 (bs,1H), 3.57 (s, 2H), 3.11-2.90 (m, 4H), 2.34-2.31 (m, 2H), 1.68-1.48 (m, 10H), 1.23 (m,2H). 
     MS: (M+1)=405.3 
     m.pt. 131-134° C. 
     IR (DCM): 1647, 1522, 1265 cm −1    
     EXAMPLE 4 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2,2-diphenyl acetate (Compound No. 4) 
     Step-a: Preparation of (1α,5α,6α)-3-benzyl-6-hydroxymethyl-3-azabicyclo[3.1.0]hexane synthesized as per reported procedure of EP 0 413 455 A2. 
     Step b: Preparation of (1α,5α,6α)-3-benzyl-6-(methanesulfonyloxy)methyl-3-azabicyclo[3.1.0]hexane: 
     A solution of the title compound of preparation of Step a of Compound 4 (0.203 g; 1 mmol) and triethylamine (0.21 gms, 2 mmol) in ethyl acetate (25 ml) was cooled to −10° C. and treated with methanesulfonyl chloride (0.17 gms, 1.5 mmol). After stirring for one hour at −10° C., the reaction was poured into a saturated aqueous sodium bicarbonate solution. The organic layer was dried over sodium sulphate. Filtration and removal of the solvent in vacuo provided the title compound as a yellow oil, which was used as such in the following step without further purification. 
       1 H-NMR (CDCl 3 ) δ—values: 7.45 (m, 5 H, arom.), 4.29 (s, 2H), 3.81 (m, 2H), 3.13 (m, 4H), 2.84 (s, 3H), 1.38 (m, 3H) 
     Step c: Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2,2-diphenyl acetate: 
     To a solution of 2-hydroxy-2,2-diphenyl acetic acid (1 mmol, 0.228 gms) in xylene was added, (1α,5α,6α)-3-benzyl-6-(methanesulfonyloxy)methyl-3-azabicyclo[3.1.0]hexane: (0.28 gms, 1 mmol) followed by DBU (1,8-diazabicyclo[5,4,0]undec-7-ene, (2 mmol, 0.305 gms) and the reaction mixture refluxed for 6 hrs. The reaction mixture was then washed with water, brine and dried over sodium sulphate. The solvents were evaporated and the crude compound thus obtained was purified by column chromatography (silicagel, 100-200 mesh) eluting the compound with 20-80, ethyl acetate hexane mixture. 
       1 H-NMR (CDCl 3 ) δ—values: 7.46-7.22 (m, 15 H. arom.), 4.24 (s, 1H), 4.11-4.09 (d, 2H), 3.56 (s, 2H), 2.91-2.89 (d, 2H), 2.31-2.29 (d, 2H), 1.67-1.62 (m, 1H) 1.3 (s, 2H) 
     IR (DCM): 1724 cm −1    
     EXAMPLE 5 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 5) 
     This compound was prepared following the procedure as in Example 4, step c using 2-hydroxy-2-cyclohexyl phenyl acetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.21 (m, 10 H, arom.), 4.09-3.92 (dd, 2H), 3.69 (s,2H), 2.93-2.89 (m, 2H), 2.33-2.30 (m, 3H), 1.65-1.12 (m, 13H) 
     IR (DCM): 1720 cm −1    
     EXAMPLE 6 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 6) 
     This compound was prepared following the procedure as in Example 4, step c using 2 hydroxy-2-cyclopentyl phenyl acetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.20 (m, 10 H, arom.), 4.06-3.93 (dd, 2H), 3.57 (s,2H), 2.94-2.89 (m, 3H), 2.34-2.30 (m, 2H), 1.63-1.27 (m, 11H) 
     IR (DCM): 1718 cm −1    
     EXAMPLE 7 
     Preparation of (1α,5α,6α)-[3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl-3-azabicyclo[3.1.0]hexyl-6(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 7) 
     The compound obtained as in Example 5 was debenzylated and then N-alkylated as given below: 
     Step a: Preparation of (1α,5α,6α)-[3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate 
     A solution of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (1 mmol) in methanol (50 ml), was added to a suspension of Pd/C (10%, 0.1 gm) and the reaction mixture was hydrogenated in Parr apparatus at 45 psi for 3 hrs. The reaction mixture was filtered and concentrated to afford the title compound. 
       1 H-NMR (CDCl 3 ) δ—values: 7.65-7.15 (m, 5 H, arom.), 4.14-4.02 (dd, 2H), 3.14-2.94-(m, 3H), 2.29-2.21 (m, 2H), 1.46-1.11 (m, 13H) 
     IR (KBr): 1723 cm −1    
     Step b: Preparation of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran Synthesized as per reported procedure of EP 0 388 054 A1, 
     Step c: To a solution of (1α,5α,6α)-[3-azabicyclo[3.1.0]hexyl-6-methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (0.329 gms, 1 mmol) in dimethyl formamide (5 ml) was added potassium carbonate (2 mmol 0.276 gms), potassium iodide (1 mmol 0.166 gms) and 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran (0.275 gms, 1.2 mmol). The reaction mixture was stirred at room temperature overnight, poured into water and extracted with ethyl acetate. The combined organic layer was washed with water, brine and dried over sodium sulphate. The crude compound obtained after evaporation of the solvent under vacuum was purified by column chromatography (silica gel 100-200 mesh) eluting the compound with 20:80 ethyl acetate:hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-6.67 (m, 8 H, arom.), 4.56-4.50 (m, 2H), 4.09-3.7-(dd, 2H), 3.19-3.01 (m, 4H), 2.62-2.60 (m, 3H), 2.33-2.30 (m, 4H), 1.65-1.11 (m, 13H) 
     IR (DCM): 1721 cm −1    
     EXAMPLE 8 
     Preparation of (1α,5α,6α)-[3-(2-(2,3-dihydrobenzofuran-5yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 8) 
     The compound obtained as in Example 6 was debenzylated and then N-alkylated as given below: 
     Step a: Preparation of (1α,5α,6α)-[3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate 
     A solution of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (1 mmol) in methanol (50 ml), was added to a suspension of Pd/C (10%, 0.1 gm) and the reaction mixture was hydrogenated in Parr apparatus at 45 psi for 3 hrs. The reaction mixture was filtered and concentrated to afford the title compound. 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.26 (m, 5 H, arom.), 4.15-4.01 (dd, 2H), 3.06-2.92-(m, 3H), 2.43-2.36 (m, 2H), 1.61-1.02 (m, 11H) 
     IR (KBr): 1721 cm −1    
     Step b: To a solution of compound (1α,5α,6α)-[3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetate (0.315 g, 1 mmol) in dimethyl formamide (5 ml) was added potassium carbonate (2 mmol, 0.276 gms), potassium iodide (1 mmol 0.166 gms) and 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran (0.275 gms, 1.2 mmol). The reaction mixture was stirred at room temperature overnight, poured into water and extracted with ethyl acetate. The combined organic layer was washed with water, brine and dried over sodium sulphate. The crude compound obtained after evaporation of the solvent under vacuum was purified by column chromatography (silica gel 100-200 mesh) eluting the compound with 20:80 ethyl acetate:hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.68-6.67 (m, 8 H, arom.), 4.56-4.50 (m, 2H), 4.07-3.97-(dd, 2H), 3.19-3.02 (m, 4H), 2.33-2.30 (m, 6H), 1.37-1.25 (m, 11H) 
     IR (DCM): 1719 cm −1    
     EXAMPLE 9 
     Preparation of (1α,5α,6α)-N-[3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(amino methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 9) 
     The compound obtained as in Example 2 was debenzylated and then N-alkylated as given below: 
     Step a: Preparation of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide. 
     A solution of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (1 mmol) in methanol (50 ml), was added to a suspension of Pd/C (10%, 0.1 gm) and the reaction mixture was hydrogenated in Parr apparatus at 45 psi for 3 hrs. The reaction mixture was filtered and concentrated to afford the title compound. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-7.26 (m, 5 H, arom.), 3.15-3.09 (m, 3H), 2.95-2.81-(m, 4H), 1.71-1.2 (m, 13H) 
     IR (KBr): 1656 cm −1    
     Step b: To solution of compound (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexylphenyl acetamide (0.328, 1 mmol) in dimethyl formamide (5 ml) was added potassium carbonate (2 mmol 0.276 gms), potassium iodide (1 mmol 0.166 gms) and 5-2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran (0.275 gms, 1.2 mmol). The reaction mixture was stirred at room temperature overnight, poured into water and extracted with ethyl acetate. The combined organic layer was washed with water, brine and dried over sodium sulphate. The crude compound obtained after evaporation of the solvent under vacuum was purified by column chromatography (silica gel 100-200 mesh) eluting the compound with 20:80 ethyl acetate:hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-6.64 (m, 8H, arom.), 4.56-4.51 (t, 2H), 3.19-2.31 (m, 12H), 1.70-1.13 (m, 14H) 
     IR (DCM): 1654 cm −1  (amide carbonyl) 
     EXAMPLE 10 
     Preparation of (1α,5α,6α)-N-[3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 10) 
     The compound obtained as in Example 3 was debenzylated and then N-alkylated as given below: 
     Step a: Preparation of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide 
     A solution of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (1 mmol) in methanol (50 ml), was added to a suspension of Pd/C (10%, 0.1 gm) and the reaction mixture was hydrogenated in Parr apparatus at 45 psi for 3 hrs. The reaction mixture was filtered and concentrated to afford the title compound. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-7.23 (m, 5 H, arom.), 3.13-3.07 (m, 2H), 2.95-2.81 (m, 5H), 1.34-0.87 (m, 11H) 
     IR (KBr): 1655 cm −1    
     Step b: To a solution of compound (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (0.314 g, 1 mmol) in dimethyl formamide(5 ml) was added potassium carbonate (2 mmol 0.276 gms), potassium iodide (1 mmol 0.166 gms) and 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran (0.275 gms, 1.2 mmol). The reaction mixture was stirred at room temperature overnight, poured into water and extracted with ethyl acetate. The combined organic layer was washed with water, brine and dried over sodium sulphate. The crude compound obtained after evaporation of the solvent under vacuum was purified by column chromatography (silica gel 100-200 mesh) eluting the compound with 20:80 ethyl acetate:hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-6.67 (m, 8H, arom.), 4.56-4.51 (t, 2H), 3.19-2.29 (m, 12H), 1.70-1.11 (m, 12H) 
     IR (KBr): 1657 cm −1    
     EXAMPLE 11 
     Preparation of (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 11) 
     Step a: Preparation of 3,4-methylenedioxyphenethyl bromide 
     Synthesized as Per Reported Procedure of EP 0 388 054 A1 
     Step b: This compound was prepared following the procedure as in Example 8, step b, using 3,4-methylenedioxyphenethyl bromide instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.8-6.6 (m, 8H, arom.), 6.0 (s, 2M), 4.2-3.9 (dd, 2H), 3.2-2.3 (m, 9H), 1.7-1.1 (m, 11H) 
     IR (DCM): 1720 cm −1    
     EXAMPLE 12 
     Preparation of (1α,5α,6α)-[3-(2-(3,4methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 12) 
     This compound was prepared following the procedure as in Example 7, step c, using 3,4-methylenedioxyphenethyl bromide instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-6.6 (m, 8H, arom.), 5.91 (s, 2H), 4.09-3.92 (dd, 2H), 3.03-2.99 (m, 2H), 2.61-2.59 (m, 4H), 2.32-2.28 (m, 4H) 1.65-1.1 (m, 12H). 
     IR (DCM): 1721 cm −1    
     EXAMPLE 13 
     Preparation of (1α,5α,6α)-N-[3-(2-(3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 13) 
     This compound was prepared following the procedure as in Example 10, Step b using 3,4-methylenedioxyphenethyl bromide instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-6.59 (m, 8H, arom.), 5.91 (s, 2H), 3.05-2.27 (m, 11H), 1.66-1.24 (m, 11H) 
     IR (KBr): 1657 cm −1    
     EXAMPLE 14 
     Preparation of (1α,5α,6α)-N-[3-(2-(3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 14) 
     This compound was prepared following the procedure as in Example 9, Step b using 3,4-methylenedioxyphenethyl bromide instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-6.59 (m, 8H, arom.), 5.91 (s, 2H), 3.10-2.33 (m, 11H), 1.70-1.17 (m, 13H) 
     IR (DCM): 1653 cm −1    
     EXAMPLE 15 
     Preparation of (1α,5α,6α)-N-[3-(4-methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 15) 
     This compound was prepared following the procedure as in Example 9, Step b using 5-bromo-2-methyl-2-pentene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-6.26 (m, 5H, arom.), 5.06 (t, 1H), 2.99-2.04 (m, 12H), 1.67-1.22 (m, 19H) 
     IR (DCM): 1656 cm −1    
     EXAMPLE 16 
     Preparation of (1α,5α,6α)-N-[3-(4-methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 16) 
     This compound was prepared following the procedure as in Example 10, Step b using 5-bromo-2-methyl-2-pentene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.25 (m, 5H, arom.), 5.06 (t, 1H), 3.06-2.04 (m, 12H), 1.67-1.1 (m, 16H) 
     IR (DCM): 1652 cm −1    
     EXAMPLE 17 
     Preparation of (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 17) 
     This compound was prepared following the procedure as in Example 7, Step c using 5-bromo-2-methyl-2-pentene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.22 (m, 5H, arom.), 5.08 (t, 1H), 4.1-3.92 (dd, 2H), 3.0-2.97 (m, 2H), 2.27-2.08 (m, 7H), 1.65-1.11 (m, 19H) 
     IR (DCM): 1721 cm −1    
     EXAMPLE 18 
     Preparation of (1α,5α,6α)-[3-(4methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 18) 
     This compound was prepared following the procedure as in Example 8, Step b using 5-bromo-2-methyl-2-pentene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.26 (m, 5H, arom.), 5.07 (t, 1H), 4.09-3.94 (dd, 2H), 3.01-2.08 (m, 9H), 1.68-0.97 (m, 17H) 
     IR (DCM): 1720 cm −1    
     EXAMPLE 19 
     Preparation of (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 19) 
     This compound was prepared following the procedure as in Example 8, Step b using (1-bromoethyl)benzene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.25 (m, 10H, arom.), 4.06-3.93 (dd, 2H), 3.24-2.08 (m, 6H), 1.6-1.23 (m, 15H) 
     IR (DCM): 1719 cm −1    
     EXAMPLE 20 
     Preparation of (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl-]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 20) 
     This compound was prepared following the procedure as in Example 7, Step c using (1-bromoethyl)benzene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.18 (m, 10H, arom.), 4.09-3.7 (dd, 2H), 3.24-2.11 (m, 4H), 2.63-2.37 (m, 8H), 1.64-1.1 (m, 11H) 
     IR (DCM): 1720 cm −1    
     EXAMPLE 21 
     Preparation of (1α,5α,6α)-N-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 21) 
     This compound was prepared following the procedure as in Example 9, Step b using (1-bromoethyl)benzene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.20 (m, 10H, arom.), 3.29-2.09 (m, 9H), 1.69-0.88 (m, 16H) 
     IR (KBr): 1653 cm −1    
     EXAMPLE 22 
     Preparation of (1α,5α,6α)-N-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 22) 
     This compound was prepared following the procedure as in Example 10, Step b using (1-bromoethyl)benzene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.26 (m, 10H, arom.), 3.26-2.07 (m, 9H), 1.67-1.15 (m, 13H) 
     IR (DCM): 1651 cm −1    
     EXAMPLE 23 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(1-aminoethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide (Compound No. 23) 
     Step a: Preparation of (1α,5α,6α)-6-(1-hydroxyethyl)-3-benzyl-3-azabicyclo[3.1.0]hexane: (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-6-carboxaldehyde (synthesized as per reported procedure of EP 0 413 455 A2, 2 gm, 100 mmol) was dissolved in tetrahydrofuran (400 ml) and cooled to −70° C. Methyllithium (105 mL of a 0.98 M solution in ether, 102 mmol) was added dropwise, stirred for one hour and later allowed to attain room temperature. Saturated aqueous ammonium chloride was added to the reaction mixture, the mixture was then extracted with ethyl acetate. The combined organic layers were dried over sodium sulphate, filtered and concentrated in vacuo to provide the product as a brown oil (yield 1.68 gm). 
       1 H-NMR (CDCl 3 ) δ—values: 7.26 (m, 5H, arom.), 3.59 (s, 2H), 3.16 (m, 1H), 2.97 (m, 2H), 2.35 (m, 2H), 1.39 (m, 1H), 1.24 (m, 5H) 
     Step b: Preparation of (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-6-methylketone 
     Dimethylsulphoxide (1.65 ml, 23 mmol) was added to a solution of oxalyl chloride (1.1 ml, 12.65 mmol) in methylene chloride (350 ml) maintained at −70° C. A solution of the title compound of preparation step a (2.5 gm, 11.5 mmol) in methylene chloride (50 ml) was then added to the reaction mixture at −70° C. After the addition of triethylamine (6.4 ml, 46 mmol), the mixture was allowed to warm to room temperature, water was added and the organic layer was collected, dried over sodium sulphate, filtered and concentrated to provide a light brown oil. Column chromatography (eluant: 20% ethyl acetate in hexane) provided the title compound (yield 1.4 gms). 
       1 H-NMR (CDCl 3 ) δ—values: 7.27 (m, 5H, arom.), 3.6 (s, 2H), 3.016 (m, 2H), 2.41 (m, 3H), 2.23 (s, 3H), 1.17 (m, 2H) 
     IR (DCM): 1694 cm −1    
     Step c: Preparation of (1α,5α,6α)-6-(1-aminoethyl)-3-benzyl-3-azabicyclo[3.1.0]hexane 
     To a stirred solution of the title compound of preparation step b (1.2 gms, 5.5 mmol) and ammonium acetate (1.28 gms, 16.6 mmol) in methanol (50 ml) was added sodium cyanoborohydride (0.87 gms, 43.75 mmol) at room temperature. The mixture was stirred for 18 hours at the same temperature. After the addition of saturated aqueous sodium bicarbonate, methanol was evaporated and the mixture was extracted three times with dichloromethane (100 ml). The combined organic extract was dried over sodium sulphate, filtered and concentrated under vacuo to obtain the crude compound (yield: 0.8 gms) which was used in the next step without purification. 
       1 H-NMR (CDCl 3 ) δ—values: 7.26 (m, 5H, arom.), 3.57 (s, 2H), 2.97 (m, 2H), 2.33 (m, 2H), 2.2 (m, 1H), 1.29 to 1.13 (m, 6H) 
     IR (DCM): 1654 cm −1    
     Step d: Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(1-aminoethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide: 
     The compound of Step-d was prepared by following the procedure described in step-c of Example 1 using (1α,5α,6α)-6-(1-aminoethyl)-3-benzyl-3-azabicyclo[3.1.0]hexane instead of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.33 (m, 15H. arom.), 6.16 (m, 1H), 3.56 (m, 2H), 3.43 (m, 1H), 2.88 (m, 2H), 2.31 (m, 2H), 1.40 (m, 1H), 1.29 to 1.13 (m, 5H) 
     IR (DCM): 1656 cm −1    
     EXAMPLE 24 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(1-aminoethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 24) 
     This compound was prepared by following the procedure described in Step-b of Example 2, using (1α,5α,6α)-6-(1-aminoethyl)-3-benzyl-3-azabicyclo[3.1.0]hexane instead of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.59 to 7.09 (m, 10H, arom.), 6.52 (m, 1H), 3.55 (m, 2H), 3.25 (m, 1H), 2.90 (m, 2H), 2.25 (m, 3H), 1.37 to 0.85 (m, 16H) 
     IR (DCM): 1651 cm −1    
     EXAMPLE 25 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(1-aminoethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 25) 
     This compound was prepared by following the procedure described in Step-b of Example 3, using (1α,5α,6α)-6-(1-aminoethyl)-3-benzyl-3-azabicyclo[3.1.0]hexane instead of (1α,5α,6α)-6-aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 7.59 to 7.23 (m, 10H, arom.), 6.30 (m, 1H), 3.54 (s, 2H), 3.29 (m, 1H), 2.93 to 2.79 (m, 3H), 2.27 (m, 3H), 1.40 (m, 1H), 1.28 to 1.0 (m, 14H) 
     IR (DCM): 1651 cm −1    
     EXAMPLE 26 
     Preparation of (1α,5α,6α)-[3-(3-methyl-2-butenyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 26) 
     This compound was prepared following the procedure as in Example 7, Step c using 1-bromo-3-methylbut-2-ene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.23 (m, 5H, arom.), 5.19 (t, 1H), 4.08-3.89 (dd, 2H), 3.7 (s, 1H), 3.029-2.94 (m, 4H), 2.3-2.27 (m, 3H), 1.71-1.11 (m, 19H) 
     IR (DCM): 1721 cm −1    
     EXAMPLE 27 
     Preparation of (1α,5α,6α)-[3-(3-methyl-2-butenyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 27) 
     This compound was prepared following the procedure as in Example 8, Step b using 1-bromo-3-methylbut-2-ene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.23 (m, 5H, arom.), 5.19 (t, 1H), 4.05-3.91 (dd, 2H), 3.76 (s, 1H), 3.039-2.96 (m, 4H), 2.31-2.28 (m, 3H), 1.71-1.25 (m, 17H) 
     IR (DCM): 1721 cm −1    
     EXAMPLE 28 
     Preparation of (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 28) 
     Step a: Preparation of (2R)-(−)-2-hydroxy-2-cyclohexyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287 
     Step b: The title compound was synthesised following the procedure as in step-b of Example 2, using (2R)-(−)-2-hydroxy-2-cyclohexyl-2-phenylacetic acid instead of 2-hydroxy-2-cyclohexyl-2-phenylacetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.22 (m, 10H, arom.), 6.62 (m, 1H), 3.55 (s, 2H), 3.26-2.07 (m, 9H), 1.67-1.15 (m, 13H) 
     [α] 25±3° C. =+3.85° (0.9846% MeOH) 
     IR (DCM): 1651 cm −1    
     EXAMPLE 29 
     Preparation of (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 29) 
     Step a: Preparation of (2R)-(−)-2-hydroxy-2-cyclopentyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287. 
     Step b: The title compound was synthesised following the procedure in step-b of Example 3, using (2R)-(−)-2hydroxy-2-cyclopentyl-2-phenyl acetic acid instead of 2-hydroxy-2-cyclopentyl-2-phenylacetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.26 (m, 10H, arom.), 3.26-2.07 (m, 9H), 1.67-1.15 (m, 13H) 
     IR (DCM): 1651 cm −1    
     [α] 25° C. =+3.95° (0.936% MeOH) 
     EXAMPLE 30 
     Preparation of (2R)(+)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate (Compound No. 30) 
     Step a: Preparation of (2R)(−)2-hydroxy-2-cyclohexyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287. 
     Step b: The title compound was synthesized following the procedure as in Example 4, step c using (2R)(−)-2-hydroxy-2-cyclohexyl-2-phenyl acetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.26 (m, 10H, arom.), 3.26-2.07 (m, 9H), 1.67-1.15 (m, 13H) 
     IR (DCM): 1651 cm −1    
     [α] 25° C. =+9.8° (1.09% MeOH) 
     EXAMPLE 31 
     Preparation of (2R)(+)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 31) 
     Step a: Preparation of (2R)(−)2-hydroxy-2-cyclopentyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287. 
     Step b: The title compound was synthesised following the procedure as in Example 4, step c using (2R)(−)-2-hydroxy-2-cyclopentyl-2-phenylacetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.2 (m, 10H, arom.), 4.06 (m, 1H), 3.93 (m, 1H), 3.74 (s, 2H), 2.94-2.89 (m, 3H), 2.33-2.3 (m,2H), 1.64-1.29 (m, 11H) 
     IR (DCM): 1719 cm −1    
     [α]=+14.8° (1% MeOH) 
     EXAMPLE 32 
     Preparation of (2S)-(−)(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 32) 
     Step a: Preparation of (2S)(+)2-hydroxy-2-cyclopentyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287. 
     Step b: The title compound was synthesised following the procedure in step-b of Example 3. 
       1 H-NMR (CDCl 3 ) δ—values: 7.62-7.25 (m, 10H. arom.), 6.45 (m, 1H), 3.58 (s, 2H), 3.07-2.92 (m, 5H), 2.35 (m, 2H), 1.77-1.24 (m, 11H) 
     IR (DCM): 1651 cm −1    
     [α]=−2.09° (1.1% MeOH) 
     EXAMPLE 33 
     Preparation of (2S)-(−)-(1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate (Compound No. 33) 
     Step a: Preparation of (2S)(+)2-hydroxy-2-cyclopentyl-2-phenyl acetic acid: 
     Synthesized as per reported procedure of Paul T. Grover, et. al. J. Org. Chem. 2000, 65, 6283-6287. 
     Step b: The title compound was synthesized following the procedure as in Example 4, Step c using 2S-(−)-2-hydroxy-2-cyclopentyl-2-phenylacetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-7.2 (m, 10H, arom.), 4.06 (m, 1H), 3.93 (m, 1H), 3.58 (s, 2H), 2.94-2.9 (m, 3H), 2.33-2.31 (m, 2H), 1.66-1.19 (m, 11H) 
     IR (DCM): 1720 cm −1    
     [α]=−14.9° (1.1% MeOH) 
     EXAMPLE 34 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide L-(+)-tartrate salt (Compound No. 34) 
     (1α,5α,6α)-N-[3-benzyl-3-bicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No 3, 1 mmol) was dissolved in ethanol (10 ml) and a solution of L-(+)-tartaric acid (1 mmol) in ethanol (5 ml) was added and stirred at 60° C. for 1 hr. The reaction mixture was then concentrated by the evaporation of solvents under reduced pressure. The resulting solid was triturated with diethyl ether and diethyl ether was removed under reduced pressure to afford the title compound as a white solid. 
       1 H-NMR (CDCl 3 ) δ—values: 7.86 (dd, 1H, Ar—H), 7.56 (dd, 2H, Ar—H), 7.33-7.16 (m, 7H,Ar—H), 5.5(bs,1H),3.76(s,2H,benzylic), 2.97-2.77 (m, 5H), 2.50-2.45 (m, 2H), 1.50-1.22 (m, 13H) 
     IR (KBr): 1735 cm −1 , 1653 cm −1    
     MS: [404.8]; HPLC (99% pure). 
     EXAMPLE 35 
     Preparation of (2R)-(+)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide. L(+)-tartrate salt (Compound No. 35) 
     2(R)-(+)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (Compound No. 29, 1 mmol) was dissolved in methanol (10 ml)and L(+)-tartaric acid was added and stirred at 60° C. for 1 hr. The reaction mixture was concentrated under reduced pressure, the resulting solid was triturated with diethylether and it was filtered off 
     m.p.: 95° C., starts decomposing 
     IR(KBr):1735 cm −1 ,1655 cm −1 . 
     HPLC:99% ee 
     [α] 25° C. =+10° (1.02% MeOH) 
     EXAMPLE 36 
     (2S)-(−)-(1α,5α,6α)-N-[3 -benzyl-3 -azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide.L(+)-tartrate salt (Compound No. 35 
     (2S)-(−)-(1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (Compound 32, 1 mmol) was dissolved in ethanol (10 ml) and a solution of L(+)tartaric acid (1 mmol) in ethanol was added and stirred at 60° C. for 1 hr. The reaction mixture was then concentrated by evaporation of solvents under reduced pressure. Dichloromethane was added to remove last traces of ethanol and to give a solid. 
     m.p.: −56° C. 
     IR (KBr):1739 cm −1 , 1653 cm −1    
     EXAMPLE 37 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2hydroxy-2-cyclobutyl-2-phenylacetamide (Compound No. 37) 
     Step a: Preparation of 2-hydroxy-2-cyclobutyl-2-phenyl acetic acid synthesised as per reported procedure of Saul B. Kadin and Joseph G. Cannon. J. Org. Chem., 1962, 27, 240-245. 
     Step b: Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclobutyl-2-phenylacetamide. 
     The compound of step b was prepared by following the procedure in step c of Example 1, using 2-hydroxy-2-cyclobutyl-2-phenyl acetic acid instead of 2-hydroxy-2,2-diphenyl acetic acid. 
       1 H NMR(CDCl 3 ) δ—values: 7.50-7.22 (m, 10H, Aromatic),6.22(s, 1H), 3.55-1.22 (m, 19H). 
     EXAMPLE 38 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopropyl-2-phenylacetamide (Compound No. 38) 
     Step a: Preparation of 2-hydroxy-2-cyclopropyl-2-phenyl acetic acid. 
     Synthesised as per reported procedure of Saul B. Kadin and Joseph G. Cannon. J. Org. Chem., 1962,27,240-245. 
     Step b: Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopropyl-2-phenylacetamide. 
     The title compound was prepared by following the procedure described in step-c of Example 1, using 2-hydroxy-2-cyclopropyl phenylacetic acid instead of 2-hydroxy-2,2-diphenylacetic acid. 
       1 H-NMR(CDCl 3 ) δ—values: 7.63-7.23(m, 10H, aromatic), 6.11(s,1H),3.56(s,2H), 3.14-2.04(m,6H),1.59-1.25(m,10H). 
     EXAMPLE 39 
     Preparation of (1α,5α,6α)-N-[3-(3-methyl-2-butenyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)yl]-2-hydroxy-2-cyclohexyl-2-phenylacetamide (Compound No. 39) 
     The compound was prepared by using the procedure in Example 9, step b, using 1-bromo-3-methylbut-2-ene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.66-7.02(m,5H,Aromatic),5.49(t,1H), 3.65-2.87 (m, 9H), 1.86-0.87 (m, 19H) 
     EXAMPLE 40 
     Preparation of (1α,5α,6α)-[3-(3,4-methylenedioxyphenyl)methyl-3-azabicyclo[3.1.0]hexyl-6(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetate (Compound No. 40) 
     Step a: Preparation of 3,4-methylenedioxy benzyl bromide. 
     Phosphorus tribromide (0.35 mmol) was added to a solution of 3,4-methylenedioxy benzyl alcohol (1 mmol) in 10 ml of carbon tetrachloride at room temperature. The reaction mixture was refluxed for 4 hrs., cooled to room temperature and washed with sodium carbonate solution (10 ml). The organic layer was dried and concentrated under reduced pressure to give the required product which was used as such for the next step. 
     Step b: (1α,5α,6α)-[3-(3,4-methylenedioxyphenyl)methyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetate. 
     The title compound was prepared using the procedure in Example 8, step b, using 3,4-methylenedioxy benzyl bromide instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.67-6.67(m, 8H, aromatic),5.94(s,2H),4.10-3.92(dd,2H), 3.71(s,1H),3.47(s,2H),2.91-2.87(m,2H),2.30-2.27(m,3H),1.64-1.12 (m, 13H) 
     IR (DCM): 1720 cm −1    
     EXAMPLE 41 
     Preparation of (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)yl]-2-hydroxy-2-cyclopentyl-2-phenylacetate. L(+)-tartrate salt (Compound No. 41). 
     The compound was prepared by using the procedure in Example 34 using (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate in place of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide. 
     m.p.:88-91° C. 
     IR(KBr): 1725 cm −1 ,1608 cm −1 . 
     EXAMPLE 42 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2,2 diphenyl acetate. L(+)-tartrate salt (Compound No. 42) 
     The compound was prepared by using the method of Example 34 using (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2,2diphenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide. 
     m.p.: 53-54° C. 
     IR(DCM): 1730 cm −1 . 
     EXAMPLE 43 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate. L(+)-tartrate salt (Compound No. 43) 
     The compound was prepared by using the method of Example 34 using (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide. 
     m.p.: 54° C. 
     IR(DCM): 1725 cm −1 . 
     EXAMPLE 44 
     Preparation of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate. L(+)-tartrate salt (Compound No. 44) 
     The compound was prepared by using the method of Example 34 using (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide. 
     m.p.: 55° C. 
     IR(DCM):1726 cm −1 . 
     EXAMPLE 45 
     Preparation of (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 45) 
     This compound was prepared following the procedure as in Example 9, Step b using 3-chloromethylpyridine hydrochloride instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 8.49-8.47 (m, 2H, aromatic); 7.62-7.21 (m, 7H, Aromatic); 6.66 (bs, 1H), 3.56 (s, 2H), 3.07-2.30 (m, 8H), 1.76-1.21 (m, 12H). 
     EXAMPLE 46 
     Preparation of (1α,5α,6α)-N-[3-(4pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenylacetamide (Compound No. 46) 
     This compound was prepared following the procedure as in Example 9, Step b using 4-chloromethylpyridine hydrochloride instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
     m.pt.: 61-62° C. 
       1 H-NMR (CDCl 3 ) δ—values: 8.52-8.50 (m, 2H, aromatic); 7.62-7.18 (m, 7H, Aromatic); 6.71 (bs, 1H), 3.56 (s, 2H), 3.08-2.30 (m, 7H), 1.70-1.17 (m, 13H). 
     IR(KBr): 1658 cm −1    
     EXAMPLE 47 
     Preparation of (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (Compound No. 47) 
     This compound was prepared following the procedure as in Example 10, Step b using 2-chloromethylpyridine hydrochloride instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
     m.pt.: 62-63° C. 
       1 H-NMR (CDCl 3 ) δ—values: 8.52-8.50 (m, 2H, aromatic); 7.65-7.12 (m, 7H, Aromatic); 6.68 (bs, 1H), 3.73 (s, 2H), 3.00-2.36 (m, 8H), 1.76-1.16 (m, 12H). 
     IR (KBr): 1654 cm −1    
     EXAMPLE 48 
     Preparation of (1α,5α,6α)-N-[3-(4-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (Compound No. 48) 
     This compound was prepared following the procedure as in Example-10, Step b using 4-chloromethyl pyridinehydrochloride instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 8.51-8.49 (m, 2H, Aromatic), 7.63-7.18 (m, 7H, aromatic), 6.64 (bs, 1H), 3.56 (s, 2H) 
     EXAMPLE 49 
     Preparation of (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenylacetamide (Compound No. 49) 
     The compound obtained as in Example-1 was debenzylated and then N-alkylated as given below: 
     Step-a: Preparation of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide: 
     This was synthesized using the same procedure as per Example 8, Step-a using (1α, 5α,6α)-N-3-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide instead of (1α,5α,6α)-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetate 
       1 H-NMR (CDCl 3 ) δ—values: 7.44-7.25 (m, 10H, Aromatic), 3.26-2.27 (m, 7H), 1.40-1.27 (m, 2H) 
     Step-b: To a solution of compound (1α,5α,6α)-N-[3-azabicyclo[3.1.0]-hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenylaceticamide (0.322 g, 1 mmol) in dimethyl formamide (5 ml) was added 3-chloromethylpyridine hydrochloride (0.246, 1.5 mmol) and potassium carbonate (2 mmol, 0.276 g), potassium iodide (1 mmol, 0.166 g)) and 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran (0.275 gms, 1.2 mmol). The reaction mixture was stirred at RT overnight, poured into water and extracted with ethyl acetate. The combined organic layer was washed with water, brine and dried over sodium sulphate. The crude compound obtained after evaporation of the solvent under vacuum was purified by column chromatography (silica gel 100-200 mesh) eluting the compound with 20:80 ethyl acetate:hexane. 
       1 H-NMR (CDCl 3 ) δ—values: 8.51-8.50 (m, 2H, aromatic), 7.64-7.25 (m, 12H, aromatic), 6.47 (bs, 1H), 3.61 (s, 2H), 3.23-3.18 (m, 2H), 2.96-2.88 (m, 2H), 2.10-2.03 (m, 2H), 1.48-1.14 (m, 3H). 
     IR (DCM): 1646 cm −1    
     EXAMPLE 50 
     Preparation of (1α,5α,6α)-N-[3-(4-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide (Compound No. 50) 
     This compound was prepared following the procedure as in Example 49, Step b using 4-chloromethyl pyridine hydrochloride instead of 3-chloromethyl pyridine hydrochloride. 
       1 H-NMR (CDCl 3 ) δ—values: 8.48-8.46 (m, 2H, Aromatic), 7.66-7.18 (m, 12H, Aromatic), 6.52 (bs, 1H), 3.57 (s, 2H), 3.20-3.16 (m, 2H), 2.96-2.93 (m, 2H), 2.35-2.30 (m, 2H), 1.60-1.25 (m, 3H). 
     IR (KBr): 1658 cm −1    
     EXAMPLE 51 
     Preparation of (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide (Compound No. 51) 
     A solution of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenylacetamide (0.322 g, 1 mmol), 2-pyridine carboxaldehyde (0.256 g, 2.4 mmol), sodium triacetoxy borohydride (0.678 g, 3.2 mmol) and acetic acid (0.228 g, 3.8 mmols) in tetrahydrofuran (25 ml) was stirred for 4 days. The reaction mixture was poured into saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulphate and concentrated under reduced pressure. The residue was purified by column chromatography (100×200 mesh, size silicagel) using 80:20 ethyl acetate:dichloromethane. 
       1 H-NMR (CDCl 3 ) δ—values: 8.53-8.52 (m, 1H, Aromatic), 7.67-7.14 (m, 13H, Aromatic), 6.39 (bs, 1H), 3.74 (s, 2H), 3.20-3.16 (m, 2H), 3.01-2.98 (m, 2H), 2.15-2.02 (m, 3H), 1.33-1.19 (m, 2H) 
     IR(KBr): 1658 cm −1    
     EXAMPLE 52 
     Preparation of (1α,5α,6α)-N-[3-(2-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 52) 
     This compound was synthesized following the procedure of Example 51 using (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide instead of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide. 
       1 H-NMR (CDCl 3 ) δ—values: 8.52 (m, 1H, Aromatic), 7.67-7.16 (m, 8H, Aromatic), 6.47 (bs, 1H), 3.74 (s, 2H), 3.08-2.02 (m, 9H), 1.66-0.88 (m, 10H) 
     IR (KBr): 1644 cm −1    
     EXAMPLE 53 
     Preparation of (1α,5α,6α)-N-[3-(3-pyridylmethyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 53) 
     This compound was synthesized using the procedure of Example 10, Step b but using 3-chloromethylpyridine hydrochloride instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b) benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 8.53-8.51 (m, 2H, Aromatic), 7.63-7.18 (m, 7H, Aromatic), 6.5 (bs, 1H), 3.57 (s, 2H), 3.12-3.91 (m, 6H), 2.33-2.31 (m, 2H), 1.40-1.17 (m, 10H) 
     IR (KBr): 1642 cm −1    
     EXAMPLE 54 
     Preparation of (1α,5α,6α)-N-[3-(3-methyl-2-butenyl)-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide (Compound No. 54) 
     This compound was synthesized by following the procedure of Example 10, Step b but using 1-bromo-3-methyl-but-2-ene instead of 5-(2-bromoethyl)-2,3-dihydrobenzo[2,3-b]benzofuran. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-7.26 (m, 5H, Aromatic), 6.43 (bs, 1H), 5.20 (t, 1H), 3.07-2.98 (m, 7H), 2.33-2.30 (m, 2H), 1.76-0.92 (m, 17H) 
     EXAMPLE 55 
     Preparation of (1α,5α,6α)-N-[3-(3,4-methylenedioxyphenyl)methyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenylacetamide (Compound No. 55) 
     This compound was synthesized by following the procedure of Example 51 but using 3,4-methylenedioxybenzaldehyde instead of 2-pyridine carboxaldehyde, and (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenyl acetamide instead of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenylacetamide. 
     m.p.: 148-150° C. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-6.66 (m, 8H, Aromatic), 6.42 (bs, 1H), 5.93 (s, 2H), 3.46 (s, 2H), 3.19-2.88 (m, 6H), 2.29-2.27 (m, 2H), 1.71-1.22 (m, 11H) 
     IR (KBr): 1652 cm −1    
     EXAMPLE 56 
     Preparation of (1α,5α,6α)-N-[3-(3,4-methylenedioxyphenyl)methyl-3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetamide (Compound No. 56) 
     This compound was synthesized by following the procedure of Example 51 but using (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenylacetamide instead of (1α,5α,6α)-N-[3-azabicyclo[3.1.0]hexyl-6-(aminomethyl)-yl]-2-hydroxy-2,2-diphenylacetamide and 3,4-methylenedioxybenzaldehyde instead of 2-pyridine carboxaldehyde. 
     m.p.: 130-133° C. 
       1 H-NMR (CDCl 3 ) δ—values: 7.61-6.68 (m, 8H) 5.93 (s, 2H), 3.45 (s, 2H), 2.92-2.84 (m, 5H), 2.28-2.26 (m, 2H), 1.34-1.17 (m, 13H) 
     IR (KBr): 1651 cm −1    
     EXAMPLE 57 
     Preparation of (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate. L(+) tartrate salt (Compound No. 57) 
     This compound was synthesized by following the procedure of Example 34 but using (1α,5α,6α)-[3-(4-methyl-3-pentenyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide. 
     m.p.: 87-89° C. 
     HPLC: 94.6% 
     EXAMPLE 58 
     Preparation of (1α,5α,6α)-[3-(2-3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate. L(+) tartrate salt (Compound No. 58) 
     This compound was synthesized by following the procedure of Example 34 but using (1α,5α,6α)-[3-(2-(3,4-methylenedioxyphenyl)ethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclohexyl-2-phenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide. 
     m.p.: 76° C. (starts decomposing) 
     HPLC: 97.48% 
     EXAMPLE 59 
     Preparation of (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-(methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate. L(+) tartrate salt (Compound No. 59) 
     This compound was synthesized following the procedure of Example 34 but using (1α,5α,6α)-[3-(1-phenylethyl)-3-azabicyclo[3.1.0]hexyl-6-methyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetate instead of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]hexyl-6(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide. 
     m.p.: 78° C. (starts decomposing) 
     HPLC:94.2% 
     EXAMPLE-60 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]-hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide hydrochloride salt (Compound No. 60) 
     This compound was synthesized by the following procedure: 
     Ethereal hydrochloric acid (10 ml) was added to a solution of compound 3 (1 mmol) in ethanol (5 ml). The reaction mixture was stirred at room temperature and then concentrated under reduced pressure. 
     HPLC:96.39% 
     EXAMPLE 61 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]-hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide. L(−) malic acid salt (Compound No. 61) 
     This compound was synthesised by following the procedure of Example 34 but using L(−) malic acid instead of L-(+) tartaric acid 
     HPLC:98.28% 
     EXAMPLE 62 
     Preparation of (1α,5α,6α)-N-[3-benzyl-3-azabicyclo[3.1.0]-hexyl-6-(aminomethyl)-yl]-2-hydroxy-2-cyclopentyl-2-phenyl acetamide. Maleate salt (Compound No. 62) 
     This compound was synthesized by following the procedure of Example 34 but using malic acid instead of L-(+) tartaric acid 
     HPLC:98.37% 
     Biological Activity 
     Radioligand Binding Assays: 
     The affinity of test compounds for M 2  and M 3  muscarinic receptor subtypes was determined by [ 3 H]-N-methylscopolamine binding studies using rat heart and submandibular gland respectively as described by Moriya et al., (Life Sci, 1999, 64 (25):2351-2358) with minor modifications. 
     Membrane preparation: Submandibular glands and heart were isolated and placed in ice cold homogenising buffer (HEPES 20 mM, 10 mM EDTA, pH 7.4) immediately after sacrifice. The tissues were homogenised in 10 volumes of homogenising buffer and the homogenate was filtered through two layers of wet gauze and filtrate was centrifuged at 500 g for 10 min. The supernatant was subsequently centriged at 40,000 g for 20 min. The pellet thus obtained was resuspended in same volume of assay buffer (HEPES 20 mM, EDTA 5 mM, pH 7.4) and were stored at −70° C. until the time of assay. 
     Ligand binding assay: The compounds were dissolved and diluted in DMSO. The membrane homogenates (150-250 μg protein) were incubated in 250 μl of assay buffer (HEPES 20 mM, pH 7.4) at 24-25° C. for 3 h. Non-specific binding was determined in the presence of 1 μM atropine . The incubation was terminated by vacuum filtration over GF/B fiber filters(Wallac). The filters were then washed with ice cold 50 mM Tris HCl buffer (pH 7.4). The filter mats were dried and bound radioactivity retained on filters was counted. The IC 50  &amp; Kd were estimated by using the non-linear curve fitting program using G Pad Prism software. The value of inhibition constant Ki was calculated from competitive binding studies by using Cheng &amp; Prusoff equation ( Biochem Pharmacol , 1973, 22: 3099-3108), Ki=IC 50 /(1+L/Kd), where L is the concentration of [ 3 H]NMS used in the particular experiment. 
     Functional Experiments using Isolated Rat Bladder: 
     Methodology: 
     Animals were euthanized by overdose of urethane and whole bladder was isolated and removed rapidly and placed in ice cold Tyrode buffer with the following composition (mMol/L) NaCl 137; KCl 2.7; CaCl 2  1.8; MgCl 2  0.1; NaHCO 3  11.9; NaH 2 PO 4  0.4; Glucose 5.55 and continuously gassed with 95% O 2  and 5% CO 2 . 
     The bladder was cut into longitudinal strips (3 mm wide and 5-6 mm long) and mounted in 10 ml organ baths at 30° C., with one end connected to the base of the tissue holder and the other end connected to a polygraph through a force displacement transducer. Each tissue was maintained at a constant basal tension of 2 g and allowed to equilibrate for 1 hour during which the PSS was changed every 15 min. At the end of equilibration period the stabilization of the tissue contractile response was assessed with 1 μmol/L of Carbachol consecutively for 2-3 times. Subsequently a cumulative concentration response curve to carbachol (10 −9  mol/L to 3×10 −5  mol/L) was obtained. After several washes, once the baseline was achieved, cumulative concentration response curve was obtained in presence of NCE (NCE added 20 min. prior to the second CRC). 
     The contractile results were expressed as % of control E max. ED50 values were calculated by fitting a non-linear regression curve (Graph Pad Prism). pKB values were calculated by the formula pKB=−log[(molar concentration of antagonist/(dose ratio−1))] 
     where, 
     dose ratio=ED50 in the presence of antagonist/ED50 in the absence of antagonist. 
     In Vivo Experiments Using Anaesthetized Rabbit 
     Methodology 
     Male rabbits were anaesthetized with urethane 1.5 g/kg intravenously. Trachea was cannulated to maintain the patency of airway. Femoral vein and femoral arteries of both sides were cannulated for the administration of vehicle or drug substances for the measurement of BP and administration of carbachol intra-arterially respectively. 
     Polyethylene tubing was introduced into the bladder through the urethra and tied at the neck of the bladder. The other end of the catheter was connected to the Grass polygraph through a Statham pressure transducer. The bladder was filled with warm (37° C.) saline. Both the ureters were ligated and cut proximally to drain the urine coming from kidneys. A stabilization period of 30-60 was allowed for stabilization of parameters from surgical procedures. 
     Salivary response was assessed by measuring the weight of a preweighted cotton gauze kept for 2 minutes in the buccal cavity immediately after the carbachol challenge. 
     At the end of stabilization period 2 control responses to carbachol (1.5 μg/kg intra-arterial) on bladder pressure and salivation were obtained and this response was considered as 100%. Subsequently, the effect of increasing dose of NCE (ranging from 3 μg/kg to 1 mg/kg) or vehicle (i.v., 15 min before carbachol challenge) was examined. 
     The change in bladder pressure and salivation were expressed as % change from pretreatment control averages. The ID 50  values for salivation and bladder pressure inhibition were calculated using Graph Pad Prism software, by fitting the values at dose into non-linear regression curve. Oxybutynin and Tolterodine were used as standards for comparison. 
     The bladder selectivity to salivation was calculated by using following formula and expressed as fold of selectivity of oxybutinin in the same model. 
     
       
         
           
             
               
                 ID 
                 50 
               
               ⁢ 
               
                   
               
               ⁢ 
               Salivary 
               ⁢ 
               
                   
               
               ⁢ 
               response 
             
             
               
                 ID 
                 50 
               
               ⁢ 
               
                   
               
               ⁢ 
               Bladder 
               ⁢ 
               
                   
               
               ⁢ 
               pressure 
             
           
         
       
     
     The results of the in-vitro and in-vivo tests are listed in Tables II and III. 
     In-Vitro Tests 
                                                                             TABLE II                           Receptor Binding Assay   Functional                M 2     M 3     Selectivity   Assay           pKi   pKi   M 2 /M 3     pK B                          Compound No. 1   6.59   7.6   10   8.14       Compound No. 2   6.85   8.25   25   8.7       Compound No. 3   7.02   8.23   16   8.6       Compound No. 4   8.6   9.41   6   8.79       Compound No. 5   8.4   8.91   3   7.4       Compound No. 6   8.46   9.25   6   8.5       Compound No. 7   7.9   8.23   2   7.88       Compound No. 8   7.87   8.05   15       Compound No. 9   6.59   7.41   6.6   6.77       Compound No. 10   6.47   7.49   10.47   7.87       Compound No. 11   8.03   8.62   3.89   8.40       Compound No. 12   7.64   8.38   5.49   8.42       Compound No. 13   6.48   7.28   6.3   7.21       Compound No. 14   5.7   6.72   10.5       Compound No. 15   6.59   7.87   19   7.81       Compound No. 16   6.75   7.63   7.6   7.94       Compound No. 17   8.36   9.1   5.5   8.09       Compound No. 18   8.4   9.15   5.6   7.4       Compound No. 19   8.15   8.8   4.5   7.99       Compound No. 20   7.9   8.73   6.8   7.1       Compound No. 21   6.59   7.82   17   7.5       Compound No. 22   7.06   8.23   14.8   7.65       Compound No. 23   6.23   6.8   3.7       Compound No. 24   6.56   7.51   8.9   7.54       Compound No. 25   6.37   7.6   17   7.9       Compound No. 26   9.52   9.5   0.95   7.94       Compound No. 27   9.65   9.85   1.6   8.27       Compound No. 28   7.85   8.4   3.5   8.5       Compound No. 29   7.91   8.96   11.2   9.15       Compound No. 30   9.13   9.46   2   8.79       Compound No. 31   9.15   9.75   3.98   8.37       Compound No. 32   6.2   7.65   28   7.8       Compound No. 33   7.39   8.4   10.23       Compound No. 34   7.22   8.23   8   8.8       Compound No. 35   7.35   8.46   13   9.21       Compound No. 36   6.21   7.65       7.8       Compound No. 37   7.24   8.23   8       Compound No. 38   6.37   7.19   6.6       Compound No. 39   7.79   8.36   3.7       Compound No. 40   9.08   9.36   1.9       Compound No. 41   8.1   8.23   1.25   8.35       Compound No. 42   8.63   9.3   4.64   8.46       Compound No. 43   8.15   8.46   2.02   7.7       Compound No. 44   8.63   9.16   3.7   7.81       Compound No. 45   &lt;6   6.63       Compound No. 46   &lt;6   7.17       Compound No. 47   6.15   7.42       Compound No. 48   &lt;6   7.14       Compound No. 49   &lt;6   7.16       Compound No. 50   &lt;6   6.94       Compound No. 57   8.46   9.34       7.5       Compound No. 58   7.82   8.3       7.55       Compound No. 60   7.31   8.28       8.38       Compound No. 61   7.36   8.29       8.66       Compound No. 62   7.28   8.17       8.94       Tolterodine   8.4   8.3   0.98   9.05       Oxybutynin   8.3   9.2   7.34   8.93       Atropine   9   9.6   0.83   9.96                    
In-Vivo Tests
 
     
       
         
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE III 
               
               
                   
               
               
                   
                 IC 50  Bladder 
                 IC 50  Salivary 
                 Fold 
                 Fold of 
               
               
                 Compound 
                 Pressure 
                 Response 
                 Selectivity 
                 Oxybutynin 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Oxybutynin 
                  36.6 ± 12 
                 21.6 + 5 
                 0.58 + 0 
                 1.0 
               
               
                 Tolterodine 
                  26.9 + 4 
                 35.1 + 9 
                 1.76 + 0 
                 2.31 
               
               
                 Compound 
                 20.13 + 2 
                 15.41 + 1  
                 0.80 + 0 
                 1.38 
               
               
                 No. 42 
               
               
                 Compound 
                 53.81 + 2 
                 85.06 + 28 
                 1.94 + 0 
                 3.34 
               
               
                 No. 43 
               
               
                 Compound 
                 23.25 + 6 
                 18.62 + 4  
                 1.09 + 0 
                 1.88 
               
               
                 No. 44 
               
               
                 Compound 
                 15.84 
                 31.62 
                 — 
                 3.45 
               
               
                 No. 35 
               
               
                 Compound 
                 398.1 
                 501.2 
                 — 
                 2.17 
               
               
                 No. 36 
               
               
                   
               
             
          
         
       
     
     While the present invention has been described in terms of its specific embodiments, certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.