Abstract:
The present invention encompasses structures of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted phenyl; 
     X is hydrogen, hydroxy or lower alkyl; 
     T is hydrogen, halogen, hydroxy, nitro, amino or alkyl; 
     R 3  is hydrogen or an organic group; 
     R 4  is hydrogen or substituted or unsubstituted organic substituent; 
     R 5  and R 6  represent organic, and inorganic substituents; and 
     n is 1, 2, 3, or 4, 
     which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

Description:
This application is a continuation-in-part of U.S. application Ser. No. 08/473,509, filed Jun. 7, 1995, now U.S. Pat. No. 5,608,079, which is a continuation of U.S. application Ser. No. 08/144,138, filed Oct. 27, 1993, now U.S. Pat. No. 5,484,944, the disclosures of which are incorporated herein in their entirety; this application is also a continuation-in-part of International Application No. PCT/US94/12300, filed Oct. 26, 1994, the disclosure of which is incorporated herein in its entirety, which is a continuation-in-part of U.S. application Ser. No. 08/144,138, filed Oct. 27, 1993, now U.S. Pat. No. 5,484,944. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     This invention relates to certain fused pyrrolecarboxanilides which selectively bind to GABAa receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating anxiety, sleep and seizure disorders, and overdoses of benzodiazepine-type drugs, and enhancing alertness. The interaction of fused pyrrolecarboxanilides of the invention with a GABA binding site, the benzodiazepine (BDZ) receptor, is described. This interaction results in the pharmacological activities of these compounds. 
     2. Description of the Related Art 
     γ-Aminobutyric acid (GABA) is regarded as one of the major inhibitory amino acid transmitters in the mammalian brain. Over 30 years have elapsed since its presence in the brain was demonstrated (Roberts &amp; Frankel, J. Biol. Chem 187: 55-63, 1950; Udenfriend, J. Biol. Chem. 187: 65-69, 1950). Since that time, an enormous amount of effort has been devoted to implicating GABA in the etiology of seizure disorders, sleep, anxiety and cognition (Tallman and Gallager, Ann. Rev. Neuroscience 8: 21-44, 1985). Widely, although unequally, distributed through the mammalian brain, GABA is said to be a transmitter at approximately 30% of the synapses in the brain. In most regions of the brain, GABA is associated with local inhibitory neurons and only in two regions is GABA associated with longer projections. GABA mediates many of its actions through a complex of proteins localized both on cell bodies and nerve endings; these are called GABAa receptors. Postsynaptic responses to GABA are mediated through alterations in chloride conductance that generally, although not invariably, lead to hyperpolarization of the cell. Recent investigations have indicated that the complex of proteins associated with postsynaptic GABA responses is a major site of action for a number of structurally unrelated compounds capable of modifying postsynaptic responses to GABA. Depending on the mode of interaction, these compounds are capable of producing a spectrum of activities (either sedative, anxiolytic, and anticonvulsant, or wakefulness, seizures, and anxiety). 
     1,4-Benzodiazepines continue to be among the most widely used drugs in the world. Principal among the benzodiazepines marketed are chlordiazepoxide, diazepam, flurazepam, and triazolam. These compounds are widely used as anxiolytics, sedative-hypnotics, muscle relaxants, and anticonvulsants. A number of these compounds are extremely potent drugs; such potency indicates a site of action with a high affinity and specificity for individual receptors. Early electrophysiological studies indicated that a major action of benzodiazepines was enhancement of GABAergic inhibition. The benzodiazepines were capable of enhancing presynaptic inhibition of a monosynaptic ventral root reflex, a GABA-mediated event (Schmidt et al., 1967, Arch. Exp. Path. Pharmakol. 258: 69-82). All subsequent electrophysiological studies (reviewed in Tallman et al. 1980, Science 207: 274-81, Haefley et al., 1981, Handb. Exptl. Pharmacol. 33: 95-102) have generally confirmed this finding, and by the mid-1970s, there was a general consensus among electrophysiologists that the benzodiazepines could enhance the actions of GABA. 
     With the discovery of the &#34;receptor&#34; for the benzodiazepines and the subsequent definition of the nature of the interaction between GABA and the benzodiazepines, it appears that the behaviorally important interactions of the benzodiazepines with different neurotransmitter systems are due in a large part to the enhanced ability of GABA itself to modify these systems. Each modified system, in turn, may be associated with the expression of a behavior. 
     Studies on the mechanistic nature of these interactions depended on the demonstration of a high-affinity benzodiazepine binding site (receptor). Such a receptor is present in the CNS of all vertebrates phylogenetically newer than the boney fishes (Squires &amp; Braestrup 1977, Nature 166: 732-34, Mohler &amp; Okada, 1977, Science 198: 854-51, Mohler &amp; Okada, 1977, Br. J. Psychiatry 133: 261-68). By using tritiated diazepam, and a variety of other compounds, it has been demonstrated that these benzodiazepine binding sites fulfill many of the criteria of pharmacological receptors; binding to these sites in vitro is rapid, reversible, stereospecific, and saturable. More importantly, highly significant correlations have been shown between the ability of benzodiazepines to displace diazepam from its binding site and activity in a number of animal behavioral tests predictive of benzodiazepine potency (Braestrup &amp; Squires 1978, Br. J. Psychiatry 133: 249-60, Mohler &amp; Okada, 1977, Science 198: 854-51, Mohler &amp; Okada, 1977, Br. J. Psychiatry 133: 261-68). The average therapeutic doses of these drugs in man also correlate with receptor potency (Tallman et al. 1980, Science 207: 274-281). 
     In 1978, it became clear that GABA and related analogs could interact at the low affinity (1 mM) GABA binding site to enhance the binding of benzodiazepines to the clonazepam-sensitive site (Tallman et al. 1978, Nature, 274: 383-85). This enhancement was caused by an increase in the affinity of the benzodiazepine binding site due to occupancy of the GABA site. The data were interpreted to mean that both GABA and benzodiazepine sites were allosterically linked in the membrane as part of a complex of proteins. For a number of GABA analogs, the ability to enhance diazepam binding by 50% of maximum and the ability to inhibit the binding of GABA to brain membranes by 50% could be directly correlated. Enhancement of benzodiazepine binding by GABA agonists is blocked by the GABA receptor antagonist (+) bicuculline; the stereoisomer (-) bicuculline is much less active (Tallman et al., 1978, Nature, 274: 383-85). 
     Soon after the discovery of high affinity binding sites for the benzodiazepines, it was discovered that a triazolopyridazine could interact with benzodiazepine receptors in a number of regions of the brain in a manner consistent with receptor heterogeneity or negative cooperativity. In these studies, Hill coefficients significantly less than one were observed in a number of brain regions, including cortex, hippocampus, and striatum. In cerebellum, triazolopyridazine interacted with benzodiazepine sites with a Hill coefficient of 1 (Squires et al., 1979, Pharma. Biochem. Behav. 10: 825-30, Klepner et al. 1979, Pharmacol. Biochem. Behav. 11: 457-62). Thus, multiple benzodiazepine receptors were predicted in the cortex, hippocampus, striatum, but not in the cerebellum. 
     Based on these studies, extensive receptor autoradiographic localization studies were carried out at a light microscopic level. Although receptor heterogeneity has been demonstrated (Young &amp; Kuhar 1980, J. Pharmacol. Exp. Ther. 212: 337-46, Young et al., 1981 J. Pharmacol Exp. Ther 216: 425-430, Niehoff et al. 1982, J. Pharmacol. Exp. Ther. 221: 670-75), no simple correlation between localization of receptor subtypes and the behaviors associated with the region has emerged from the early studies. In addition, in the cerebellum, where one receptor was predicted from binding studies, autoradiography revealed heterogeneity of receptors (Niehoff et al., 1982, J. Pharmacol. Exp. Ther. 221: 670-75). 
     A physical basis for the differences in drug specificity for the two apparent subtypes of benzodiazepine sites has been demonstrated by Sieghart &amp; Karobath, 1980, Nature 286: 285-87. Using gel electrophoresis in the presence of sodium dodecyl sulfate, the presence of several molecular weight receptors for the benzodiazepines has been reported. The receptors were identified by the covalent incorporation of radioactive flunitrazepam, a benzodiazepine which can covalently label all receptor types. The major labeled bands have molecular weights of 50,000 to 53,000, 55,000, and 57,000 and the triazolopyridazines inhibit labeling of the slightly higher molecular weight forms (53,000, 55,000, 57,000) (Seighart et al. 1983, Eur. J. Pharmacol. 88: 291-99). 
     At that time, the possibility was raised that the multiple forms of the receptor represent &#34;isoreceptors&#34; or multiple allelic forms of the receptor (Tallman &amp; Gallager 1985, Ann. Rev. Neurosci. 8, 21-44). Although common for enzymes, genetically distinct forms of receptors have not generally been described. As we begin to study receptors using specific radioactive probes and electrophoretic techniques, it is almost certain that isoreceptors will emerge as important in investigations of the etiology of psychiatric disorders in people. 
     The GABAa receptor subunits have been cloned from bovine and human cDNA libraries (Schoenfield et al., 1988; Duman et al., 1989). A number of distinct cDNAs were identified as subunits of the GABAa receptor complex by cloning and expression. These are categorized into ∝, β, γ, δ, ε, and provide a molecular basis for the GABAa receptor heterogeneity and distinctive regional pharmacology (Shivvers et al., 1980; Levitan et al., 1989). The γ subunit appears to enable drugs like benzodiazepines to modify the GABA responses (Pritchett et al., 1989). The presence of low Hill coefficients in the binding of ligands to the GABAa receptor indicates unique profiles of subtype specific pharmacological action. 
     Drugs that interact at the GABAa receptor can possess a spectrum of pharmacological activities depending on their abilities to modify the actions of GABA. For example, the beta-carbolines were first isolated based upon their ability to inhibit competitively the binding of diazepam to its binding site (Nielsen et al., 1979, Life Sci. 25: 679-86). The receptor binding assay is not totally predictive about the biological activity of such compounds; agonists, partial agonists, inverse agonists, and antagonists can inhibit binding. When the beta-carboline structure was determined, it was possible to synthesize a number of analogs and test these compounds behaviorally. It was immediately realized that the beta-carbolines could antagonize the actions of diazepam behaviorally (Tenen &amp; Hirsch, 1980, Nature 288: 609-10). In addition to this antagonism, beta-carbolines possess intrinsic activity of their own opposite to that of the benzodiazepines; they become known as inverse agonists. 
     In addition, a number of other specific antagonists of the benzodiazepine receptor were developed based on their ability to inhibit the binding of benzodiazepines. The best studied of these compounds is an imidazodiazepine (Hunkeler et al., 1981, Nature 290: 514-516). This compound is a high affinity competitive inhibitor of benzodiazepine and beta-carboline binding and is capable of blocking the pharmacological actions of both these classes of compounds. By itself, it possesses little intrinsic pharmacological activity in animals and humans (Hunkeler et al., 1981, Nature 290: 514-16; Darragh et al., 1983, Eur. J. Clin. Pharmacol. 14: 569-70). When a radiolabeled form of this compound was studied (Mohler &amp; Richards, 1981, Nature 294: 763-65), it was demonstrated that this compound would interact with the same number of sites as the benzodiazepines and beta-carbolines, and that the interactions of these compounds were purely competitive. This compound is the ligand of choice for binding to GABAa receptors because it does not possess receptor subtype specificity and measures each state of the receptor. 
     The study of the interactions of a wide variety of compounds similar to the above has led to the categorizing of these compounds. Presently, those compounds possessing activity similar to the benzodiazepines are called agonists. Compounds possessing activity opposite to benzodiazepines are called inverse agonists, and the compounds blocking both types of activity have been termed antagonists. This categorization has been developed to emphasize the fact that a wide variety of compounds can produce a spectrum of pharmacological effects, to indicate that compounds can interact at the same receptor to produce opposite effects, and to indicate that beta-carbolines and antagonists with intrinsic anxiogenic effects are not synonymous. 
     A biochemical test for the pharmacological and behavioral properties of compounds that interact with the benzodiazepine receptor continues to emphasize the interaction with the GABAergic system. In contrast to the benzodiazepines, which show an increase in their affinity due to GABA (Tallman et al., 1978, Nature 274: 383-85, Tallman et al., 1980, Science 207: 274-81), compounds with antagonist properties show little GABA shift (i.e., change in receptor affinity due to GABA) (Mohler &amp; Richards 1981, Nature 294: 763-65), and the inverse agonists actually show a decrease in affinity due to GABA (Braestrup &amp; Nielson 1981, Nature 294: 472-474). Thus, the GABA shift predicts generally the expected behavioral properties of the compounds. 
     Various compounds have been prepared as benzodiazepine agonists and antagonists. For Example, U.S. Pat. Nos. 3,455,943, 4,435,403, 4,596,808, 4,623,649, and 4,719,210, German Patent No. DE 3,246,932, and Liebigs Ann. Chem. 1986, 1749 teach assorted benzodiazepine agonists and antagonists and related anti-depressant and central nervous system active compounds. U.S. Pat. No. 3,455,943 discloses compounds of the formula: ##STR3## wherein R 1  is a member of the group consisting of hydrogen and lower alkoxy; R 2  is a member of the group consisting of hydrogen and lower alkoxy; R 3  is a member of the group consisting of hydrogen and lower alkyl; and X is a divalent radical selected from the group consisting of ##STR4## and the non-toxic acid addition salts thereof. 
     U.S. Pat. No. 4,435,403 teaches compounds of the formula: ##STR5## wherein R C  is hydrogen, lower alkyl, alkoxyalkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms, arylalkyl of up to 8 C-atoms, or (CH 2 ) n  OR  18  wherein R 18  is alkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms or arylalkyl of up to 8 C-atoms and n is an integer of 1 to 3; Y is oxygen, two hydrogen atoms or NOR 1 , wherein R 1  is hydrogen, lower alkyl, aryl or arylalkyl of up to 6 C-atoms, COR 2 , wherein R 2  is lower alkyl of up to 6 C-atoms, or Y is CHCOOR 3 , wherein R 3  is hydrogen or lower alkyl or Y is NNR 4  R 5 , wherein R 4  and R 5  can be the same or different and each is hydrogen, lower alkyl, C 6-10  -aryl, C 7-10  -arylalkyl or CONR 6  R 7 , wherein R 6  and R 7  can be the same or different and each is hydrogen or lower alkyl, or R 4  and R 5  together with the connecting N-atom, form a 5- or 6-membered heterocyclic ring which optionally may also contain an O-atom or up to 3 N-atoms and which optionally may be substituted by a lower alkyl group; Z is hydrogen, or alkoxy or aralkoxy each of up to 10 C-atoms and each optionally substituted by hydroxy, or Z is alkyl of up to 6 C-atoms, C 6-10  -aryl or C 7-10  -arylalkyl each of which may optionally be substituted by a COOR 8  or a CONR 9  R 10  group, wherein R 8  is alkyl of up to 6 C-atoms, and R 9  and R 10  can be the same or different and each is hydrogen or alkyl of up to 6 C-atoms; or Z is NR 9  R 10 , wherein R 9  and R 10  are as defined above; or Z is NR 11  CHR 12  R 13 , wherein R 11  and R 12  each is hydrogen or together form a N═C double bond, wherein R 13  is C 1-10  -alkyl or NR 14  R 15 , wherein R 14  and R 15  are the same or different and each is hydrogen, OH or alkyl or alkoxy each of up to 6 C-atoms, or wherein R 12  and R 13  together are oxygen, in which case, R 11  is hydrogen; or Z is COOR 2  wherein R 2  is as defined above; or Y and Z, together with the connecting C-atom, may form a 5- or 6-membered heterocyclic ring which contains an O-atom, adjoining O- and N-atoms or up to 4 N atoms and which optionally may be substituted by a lower alkyl group, hydroxy or oxo. 
     U.S. Pat. No. 4,596,808 discloses compounds of the formula: ##STR6## wherein R A  is H, F, Cl, Br, I, NO 2 , CN, CH 3 , CF 3 , SCH 3 , NR 16  R 17  or NHCOR 16 , wherein R 16  of R 17  are the same or different and each is hydrogen or alkyl, alkenyl or alkynyl each of up to 6 C-atoms, arylalkyl or cycloalkyl each of up to 10 C-atoms, or wherein R 16  and R 17  together form a saturated or unsaturated 3-7 membered heterocyclic ring. 
     U.S. Pat. No. 4,623,649 teaches compounds of the formula: ##STR7## wherein R 3  is an oxadiazolyl residue of the formula ##STR8## wherein R 5  stands for lower alkyl of up to 3 carbon atoms or an ester --CO 2  R 6  with R 6  being hydrogen or lower alkyl of up to 3 carbon atoms, R 4  is hydrogen, lower alkyl of up to 3 carbon atoms, or CH 2  OR 9  wherein R 9  is lower alkyl of up to 3 carbon atoms, R A  is phenyl or a hydrocarbon residue containing 2-10 carbon atoms which can be cyclic or acyclic, saturated or unsaturated, branched or unbranched, and which can optionally be substituted by oxo, formyl OH, O-alkyl of up to 3 carbon atoms or phenyl, and wherein in a cyclic hydrocarbon residue, a CH 2  -group can be replaced by oxygen. 
     U.S. Pat. No. 4,719,210 discloses compounds of the formula: ##STR9## wherein R 1  is hydrogen or a protecting group, R 2  is --CH═CR 4  or --C═CR 4 , R 4  is hydrogen or halogen, R 3  is hydrogen, lower alkyl or lower alkoxyalkyl, R A  is, inter alia, hydrogen, OR 7 , lower alkyl, which optionally is substituted with aryl, lower alkoxy or NR 5  R 6 , R 5  and R 6  can be the same or different and in each case is hydrogen, lower alkyl or together with the nitrogen atom a 5-6 member ring, which can contain another heteroatom. R 7  is lower alkyl, optionally substituted aryl or arylalkyl, and each compound can contain one or more R A  radicals which are not hydrogen. 
     German Patent No. DE 3,246,932 discloses compounds of the formula: ##STR10## wherein R=halogen, NO 2 , CO 2  H, modified CO 2  H, R 2  O, R 2  S(O) n  ; n=0-2; and R 1  =H, alkyl, cycloalkyl, arylalkyl, aryl, CO 2  H, amino, R 2  O, R 2  S(O) n . 
     Liebigs Ann. Chem. 1986, 1749-1764 teaches compounds of the formula: ##STR11## where R X  is hydrogen, methyl, benzyloxy, or methoxy, and R 3  is carboethoxy. 
     None of these compounds are indole-3-carboxamides and no such compounds displaying activity at GABA receptors have been described. 
     A variety of indole-3-carboxamides are described in the literature. For example, J. Org. Chem., 42: 1883-1885 (1977) discloses the following compounds. ##STR12## 
     J. Heterocylic Chem., 14: 519-520 (1977) discloses a compound of the following formula: ##STR13## 
     None of these indole-3-carboxamides includes an oxy substiuent at the 4-position of the indole ring. 
     SUMMARY OF THE INVENTION 
     This invention provides novel compounds of Formula I which interact with a GABAa binding site, the benzodiazepine receptor. 
     The invention provides pharmaceutical compositions comprising compounds of Formula I. The invention also provides compounds useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Accordingly, a broad embodiment of the invention is directed to compounds of general Formula I: ##STR14## or the pharmaceutically acceptable non-toxic salts thereof wherein: T is halogen, hydrogen, hydroxy, nitro, amino or lower alkoxy; 
     X is hydrogen, hydroxyl or lower alkyl; 
     W is phenyl or phenylalkyl where each phenyl is optionally substututed with up to 5 groups independently selected from halogen, hydroxy, lower alkyl, cycloalkyl having 3-7 carbon atoms, amino, mono- or dialkylamino where each alkyl is independently lower alkyl or cycloalkyl having 3-7 carbon atoms, lower alkoxy, cycloalkyl alkoxy having 3-7 carbon atoms, alkylenedioxy, or NR 1  COR 2 , COR 2 , or CONR 1  R 2  where R 1  and R 2  are the same or different and represent hydrogen, lower alkyl or cycloalkyl having 3-7 carbon atoms; and ##STR15## wherein: Y represents nitrogen or C--R 4  ; 
     Z represents N--R 7  or a carbon atom substituted with R 8  and R 9 , i.e., C(R 8 )(R 9 ); 
     n is 1, 2, 3, or 4; 
     R 3  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; 
     R 4  is halogen or trifluoromethyl; or 
     --OR 10 , --COR 10 , --CO 2  R 10 , --OCOR 10 , or --R 10 , where R 10  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; or 
     --CONR 11  R 12  or --(CH 2 ) m  NR 11  R 12 , where m is 0, 1, or 2; R 11  represents hydrogen, lower alkyl; and R 12  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; or NR 11  R 12  forms a heterocyclic group which is morpholinyl, piperidinyl, pyrrolidinyl, or N-alkyl piperazinyl; 
     R 5  and R 6  are the same or different and represent hydrogen, halogen, lower alkyl, or lower alkoxy; 
     R 7  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; 
     R 8  is hydrogen or lower alkyl; and 
     R 9  is --COR 13 , --CO 2  R 13  or --R 13 , where R 13  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; or 
     R 9  is --CONR 14  R 15  or --(CH 2 ) k  NR 14  R 15 , where k is 0, 1, or 2; R 14  represents hydrogen, lower alkyl; and R 15  is hydrogen, phenyl, 2-, 3-, or 4-pyridyl, lower alkyl, or phenylalkyl or 2-, 3-, or 4-pyridylalkyl where each alkyl is lower alkyl; or NR 14  R 15  forms a heterocyclic group which is morpholinyl, piperidinyl, pyrrolidinyl, or N-alkyl piperazinyl. 
     These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. In other words, while the compounds of the invention all interact with GABAa brain receptors, they do not display identical physiologic activity. Thus, these compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. For example, these compounds can easily be used to treat overdoses of benzodiazepine-type drugs as they would competitively bind to the benzodiazepine receptor. 
     DETAILED DESCRIPTION OF THE INVENTION 
     The novel compounds encompassed by the instant invention can be described by general formula I set forth above or the pharmaceutically acceptable non-toxic salts thereof. 
     In addition, the present invention encompasses compounds of Formula II. ##STR16## or the pharmaceutically acceptable non-toxic salts thereof wherein W, T, R 8  and R 9  are as defined above. 
     The present invention also encompasses compounds of Formula IIIa and IIIb: ##STR17## or the pharmaceutically acceptable non-toxic salts thereof wherein W, R 3 , and R 5  are as defined above. 
     Preferred compounds of Formula IIIb are those where R 3  is hydrogen or alkyl; and R 5  is hydrogen. 
     The present invention also encompasses compounds of Formula IV: ##STR18## or the pharmaceutically acceptable non-toxic salts thereof wherein W, Y, R 3 , and R 5  are defined above. 
     The present invention also encompasses compounds of Formula V: ##STR19## or the pharmaceutically acceptable non-toxic salts thereof wherein W, R 4 , and R 5  are defined above. 
     The invention further encompasses compounds of Formula VI: ##STR20## or the pharmaceutically acceptable non-toxic salts thereof wherein: R 16  is hydrogen, benzyl or lower alkyl; 
     R 17  is hydrogen, halogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl having 1-6 carbon atoms; 
     R 18  is hydrogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl, NR 1  COR 2 , COR 2 , CO 2  R 2  where R 1  and R 2  are as defined above, cyano, or halogen; and 
     R 19  is hydrogen, hydroxyl, or halogen. 
     The invention additionally encompasses compounds of Formula VII: ##STR21## or the pharmaceutically acceptable non-toxic salts thereof where R 17 , R 18  and R 19  are defined above. 
     The invention further encompasses compounds of Formula VIII: ##STR22## where R 17 , R 18 , and R 19  are defined above and R 20  is hydrogen or alkyl. 
     The invention further encompasses compounds of Formula IX: ##STR23## where R 17 , R 18 , and R 19  are defined above. 
     The invention further encompasses compounds of Formula X: ##STR24## where R 16 , R 17 , R 18 , and R 19  are defined above. 
     The invention further encompasses compounds of Formula XI: ##STR25## where R 4 , R 5 , R 17 , R 18 , and R 19  are defined above. 
     The invention further encompasses compounds of Formula XII: ##STR26## wherein W represents phenyl, 2- or 3-thienyl, 2-, 3-, or 4-pyridyl or 6-quinolinyl, each of which may be mono or disubstituted with halogen, cyano, hydroxy, lower alkyl, amino, mono or dialkylamino where each alkyl is independently lower alkyl, lower alkoxy, or NR 1  COR 2 , COR 2 , CONR 1  R 2  or CO 2  R 2  where R 1  and R 2  are the same or different and represent hydrogen or lower alkyl. 
     Further, the present invention provides compounds of Formula XIII: ##STR27## wherein W, R 8  and R 9  are as defined above; 
     T represents hydrogen, amino, or nitro; 
     X is alkyl or hydrogen; and 
     n is 1 or 2. 
     A preferred group of compounds of Formula XIII are those where R 8  and R 9  are independently alkyl or hydrogen; and n is 1. Another preferred group of compounds of Formula XIII are those where R 8  and R 9  are independently alkyl or hydrogen; and n is 2. Particularly preferred compounds of Formula XIII where n is 2 are those where R 8  and R 9  are hydrogen; and X and T are both hydrogen. 
     The invention also provides compounds of Formula XIV: ##STR28## wherein W is as defined above; 
     R 8  and R 9  are independently alkyl or hydrogen; and 
     X is hydrogen, methyl, or ethyl. 
     Preferred compounds of Formula XIV are those where R 8  and R 9  are both hydrogen and X is hydrogen. 
     The present invention further provides compounds of Formula XV. ##STR29## R 8  and R 9  are as defined above; A represents an alkylene group of 1-6 carbon atoms optionally substituted with up to two alkyl groups independently having 1-3 carbon atoms; 
     R 17  is hydrogen, halogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl having 1-6 carbon atoms; 
     R 18  is hydrogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl, NR 1  COR 2 , COR 2 , CO 2  R 2  where R 1  and R 2  are as defined above, cyano, or halogen; and 
     R 19  is hydrogen, hydroxyl, or halogen. 
     The present invention also encompasses compounds of Formula XVI. ##STR30## R 8  and R 9  are as defined above; A represents an alkylene group of 1-6 carbon atoms optionally substituted with up to two alkyl groups independently having 1-3 carbon atoms; 
     n is 1 or 2; 
     R 17  is hydrogen, halogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl having 1-6 carbon atoms; 
     R 18  is hydrogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl, NR 1  COR 2 , COR 2 , CO 2  R 2  where R 1  and R 2  are as defined above, cyano, or halogen; and 
     R 19  is hydrogen, hydroxyl, or halogen. 
     Further, the present invention provides compounds of Formula XVII. ##STR31## A represents an alkylene group of 1-6 carbon atoms optionally substituted with up to two alkyl groups independently having 1-3 carbon atoms; 
     R 16  is hydrogen, benzyl, or lower alkyl; 
     R 17  is hydrogen, halogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl having 1-6 carbon atoms; 
     R 18  is hydrogen, hydroxyl, lower alkyl, lower alkoxy, amino, mono or dialkylamino where each alkyl is independently striaght or branched chain lower alkyl, NR 1  COR 2 , COR 2 , CO 2  R 2  where R 1  and R 2  are as defined above, cyano, or halogen; and 
     R 19  is hydrogen, hydroxyl, or halogen. 
     Representative compounds of the invention are shown below in Table 1. 
     
                       TABLE 1______________________________________ ##STR32## ##STR33## ##STR34## ##STR35## ##STR36## ##STR37## ##STR38## ##STR39## ##STR40## ##STR41## ##STR42## ##STR43## ##STR44## ##STR45## ##STR46## ##STR47## ##STR48## ##STR49## ##STR50##______________________________________ 
    
     Representative compounds of the present invention, which are encompassed by Formula I, include, but are not limited to the compounds in Table I and their pharmaceutically acceptable salts. Non-toxic pharmaceutically acceptable salts include salts of acids such as hydrochloric, phosphoric, hydrobromic, sulfuric, sulfinic, formic, toluenesulfonic, methanesulfonic, nitric, benzoic, citric, tartaric, maleic, hydroiodic, alkanoic such as acetic, HOOC--(CH 2 ) n  --COOH where n is 0-4, and the like. Those skilled in the art will recognize a wide variety of non-toxic pharmaceutically acceptable addition salts. 
     The present invention also encompasses the prodrugs, preferably acylated prodrugs, of the compounds of Formula I. Those skilled in the art will recognize various synthetic methodologies which may be employed to prepare non-toxic pharmaceutically acceptable addition salts and acylated prodrugs of the compounds encompassed by Formula I. 
     By &#34;alkyl&#34; and &#34;lower alkyl&#34; in the present invention is meant straight or branched chain alkyl groups having 1-6 carbon atoms, such as, for example, methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, pentyl, 2-pentyl, isopentyl, neopentyl, hexyl, 2-hexyl, 3-hexyl, and 3-methylpentyl. 
     By &#34;phenylalkyl&#34; as used herein is meant a phenyl group covalently bonded to an alkyl group as defined above and the alkyl group is covalently bonded to another moiety, such as, for example, a nitrogen atom. 
     By &#34;alkoxy&#34; and &#34;lower alkoxy&#34; in the present invention is meant straight or branched chain alkoxy groups having 1-6 carbon atoms, such as, for example, methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentoxy, 2-pentyl, isopentoxy, neopentoxy, hexoxy, 2-hexoxy, 3-hexoxy, and 3-methylpentoxy. 
     By the term &#34;halogen&#34; in the present invention is meant fluorine, bromine, chlorine, and iodine. 
     By &#34;N-alkylpiperazyl&#34; in the invention is meant radicals of the formula: ##STR51## 
     where R is a lower alkyl as defined above. 
     By &#34;monoalkylamino&#34; as used herein is meant an amino substitutent substituted with one (1) alkyl group where the alkyl group is lower alkyl as defined above. 
     By &#34;dialkylamino&#34; as used herein is meant an amino substitutent substituted with two (2) alkyl groups where the alkyl groups are independently lower alkyl groups as defined above. 
     By &#34;alkylenedioxy&#34; as used herein is meant a group of the formula --O--A--O-- where A represents C 1  -C 3  alkylene optinally substituted with up to two C 1  -C 2  alkyl groups and each oxygen atom is covalently bound to the aromatic ring, i.e., the phenyl group. The oxygen atoms of such alkylenedioxy groups are typically attached to adjacent carbon atoms of the aromatic ring. 
     The pharmaceutical utility of compounds of this invention are indicated by the following assay for GABAa receptor binding activity. 
     Assays are carried out as described in Thomas and Tallman (J. Bio. Chem. 156: 9838-9842 J. Neurosci. 3: 433-440, 1983). Rat cortical tissue is dissected and homogenized in 25 volumes (w/v) of 0.05M Tris HCl buffer (pH 7.4 at 4° C.). The tissue homogenate is centrifuged in the cold (4°) at 20,000×g for 20&#39;. The supernatant is decanted and the pellet is rehomogenized in the same volume of buffer and again centrifuged at 20,000×g. The supernatant is decanted and the pellet is frozen at -20° C. overnight. The pellet is then thawed and rehomogenized in 25 volume (original wt/vol) of buffer and the procedure is carried out twice. The pellet is finally resuspended in 50 volumes (w/vol of 0.05M Tris HCl buffer (pH 7.4 at 40° C.). 
     Incubations contain 100 ml of tissue homogenate, 100 ml of radioligand 0.5 nM ( 3  H-RO15-1788   3  H-Flumazenil! specific activity 80 Ci/mmol), drug or blocker and buffer to a total volume of 500 ml. Incubations are carried for 30 min at 4° C. then are rapidly filtered through GFB filters to separate free and bound ligand. Filters are washed twice with fresh 0.05M Tris HCl buffer (pH 7.4 at 4° C.) and counted in a liquid scintillation counter. 1.0 mM diazepam is added to some tubes to determine nonspecific binding. Data are collected in triplicate determinations, averaged and % inhibition of total specific binding is calculated. Total Specific Binding=Total-Nonspecific. In some cases, the amounts of unlabeled drugs is varied and total displacement curves of binding are carried out. Data are converted to K i  values. Representative data for compounds of this invention are listed in Tables 2 and 3. 
     
                       TABLE 2______________________________________Compound Number  K.sub.i (nM)______________________________________1                42                4306                18                2512               2814               133______________________________________ 
    
     
                       TABLE 3______________________________________Compound Number  K.sub.i (nM)______________________________________22               5326               330               1035               246               362               0.872               2674               1880               3181               1486               293               696               29102              37______________________________________ 
    
     The compounds of general Formula I may be administered orally, topically, parenterally, by inhalation or spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. In addition, there is provided a pharmaceutical formulation comprising a compound of general Formula I and a pharmaceutically acceptable carrier. One or more compounds of general Formula I may be present in association with one or more non-toxic pharmaceutically acceptable carriers and/or diluents and/or adjuvants and if desired other active ingredients. The pharmaceutical compositions containing compounds of general Formula I may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsion, hard or soft capsules, or syrups or elixirs. 
     Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, corn starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monosterate or glyceryl distearate may be employed. 
     Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin or olive oil. 
     Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydropropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide, for example, lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl p-hydroxybenzoate, one or more coloring agents, one or more flavoring agents, and one or more sweetening agents, such as sucrose or saccharin. 
     Oily suspensions may be formulated by suspending the active ingredients in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavoring agents may be added to provide palatable oral preparations. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid. 
     Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example sweetening, flavoring and coloring agents, may also be present. 
     Pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol, anhydrides, for example sorbitan monoleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monoleate. The emulsions may also contain sweetening and flavoring agents. 
     Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitor or sucrose. Such formulations may also contain a demulcent, a preservative and flavoring and coloring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be sterile injectable solution or suspension in a non-toxic parentally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer&#39;s solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono-or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. 
     The compounds of general Formula I may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter and polyethylene glycols. 
     Compounds of general Formula I may be administered parenterally in a sterile medium. The drug, depending on the vehicle and concentration used, can either be suspended or dissolved in the vehicle. Advantageously, adjuvants such as local anaesthetics, preservatives and buffering agents can be dissolved in the vehicle. 
     Dosage levels of the order of from about 0.1 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the above-indicated conditions (about 0.5 mg to about 7 g per patient per day). The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient. 
     It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, and rate of excretion, drug combination and the severity of the particular disease undergoing therapy. 
     An illustration of the preparation of compounds of the present invention is given in Schemes I and II. ##STR52## where W, Z, and n are as defined above. ##STR53## 
     W, R 3 , Y, R 5 , and R 6  are as defined above. 
     Those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce compounds encompassed by the present invention, as demonstrated by the following examples. In some cases protection of certain reactive functionalities may be necessary to achieve some of the above transformations. In general the need for such protecting groups will be apparent to those skilled in the art of organic synthesis as well as the conditions necessary to attach and remove such groups. 
    
    
     The invention is illustrated further by the following examples which are not to be construed as limiting the invention in scope or spirit to the specific procedures described in them. 
     EXAMPLE 1 
     Preparation of Starting Materials and Intermediates 
     The starting materials and various intermediates may be obtained from commercial sources, prepared from commercially available organic compounds, or prepared using well known synthetic methods. 
     Representative examples of methods for preparing intermediates of the invention are set forth below. 
     1. 4-Oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylic Acid ##STR54## 
     4-Oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylic acid was prepared as follows: To a stirred solution of potassium hydroxide (28.06 g, 0.5 mol) in methyl alcohol (100 mL) under nitrogen at 0° C. was added dropwise a solution of cyclohexanedione (56.07 g, 0.5 mol) in methyl alcohol (100 mL). The mixture was stirred at 0° C. for 0.5 h, then a solution of ethyl bromopyruvate (66 mL, 0.525 mol) in methyl alcohol(100 mL) was added dropwise. After allowing the mixture to stir at ambient temperature for 17 h, a 50% aqueous sodium hydroxide solution (60 mL) was added dropwise and stirring continued an additional 7 h. After dilution with water, the solution was acidified and the methanol removed in vacuo. Ice water was added and the precipitate filtered and dried in vacuo to afford 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylic acid. m.p. 137°-138° C. 
     2. 4-Oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic Acid ##STR55## 
     To a stirred suspension of 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylic acid (28.2 g, 157 mmol) in ethyl alcohol (500 mL) under nitrogen at ambient temperature was added acetyl chloride(56 mL, 783 mmol) dropwise. After stirring 1 h, the solution was then heated at reflux for 1 h. The solution was cooled and concentrated in vacuo. The residue was taken up into dichloromethane, washed with aqueous sodium bicarbonate, washed quickly with 1N sodium hyroxide, dried over magnesium sulfate, filtered, and concentrated in vacuo to afford ethyl 4-oxo-4,5,6,7-tetrahydrobenzofuran-3-carboxylate as an oil. A mixture of this ester (24.46 g, 117 mmol) and ammonium acetate (15.85 g, 206 mmol) in N,N-dimethylformamide (225 mL) was heated at 100° C. under nitrogen for 1.25 h. The mixture was cooled, poured into ice water, and extracted two times with dichloromethane. The combined organic extracts were washed with water, dried over magnesium sulfate, filtered, concentrated in vacuo, and the residue triturated with ether to give ethyl 4-oxo-4,5,6,7-tetrahydroindole-3-carboxylate. A mixture of this ester (11.31 g, 55 mmol) in 5N sodium hydroxide (200 mL) and ethanol (20 mL) was heated at reflux for 1 h. After cooling in an ice bath, the mixture was acidified with concentrated hydrochloric acid, the precipitate filtered, rinsed with ice water, and dried in vacuo to afford 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid. m.p. 269°-270° C. 
     3. 4-Oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (m.p. 225°-228° C.) is prepared essentially according to the procedure set forth in Example 1 and part 1 of this example. 
     4. 4-Methoxy-1H-indole ##STR56## 
     A solution of 2-methyl-3-nitroanisole (9.96 g, 60 mmol) and tris(dimethylamino)methane (15.5 mL, 89 mmol) in dimethylformamide (30 mL) was heated at 115° C. under nitrogen for 3 h. After cooling to ambient temperature a solution of semicarbazide hydrochloride (6.98 g, 63 mmol) and concentrated hydrochloric acid (5.3 mL) in water (75 mL) was added dropwise with vigorous stirring. The mixture was cooled further in an ice bath and the precipitate filtered, rinsed with ice water followed by, in sequence, cold 50% aqueous ethanol, cold ethanol, and ether, then dried to give a semicarbazone. The semicarbazone was suspended with 10% palladium on carbon (3 g) in ethanol (120 mL) in a Parr shaker and placed under a hydrogen atmosphere (50 psi) for 16 h. The mixture was filtered through Celite and concentrated in vacuo. The residue was triturated with ice water, filtered and dried to give the title compound. 
     5. 4-Benzyloxy-1H-indole ##STR57## 
     A solution of 2-nitro-6-benzyloxytoluene (13.0 g, 53 mmol) and tris(dimethylamino)methane (13.9 mL, 80 mmol) in dimethylformamide (30 mL) was heated at 115° C. under Nitrogen for 3 h. Upon cooling to ambient temperature, a solution of semicarbazide hydochloride (6.26 g, 56 mmol) and concentrated hydrochloric acid (4.8 mL) in water (70 mL) was added dropwise with vigorous stirring. Ethanol (25 mL) was added and the heterogeneous mixture stirred for 2 h. After cooling in an ice bath, the precipitate was filtered, rinsed with, in sequence, ice water, cold 50% aqueous ethanol, cold ethanol, then ether and dried to give a semicarbazone. A slurry of this semicarbazone (17.64 g, 54 mmol), Raney nickel (18 g of a 50% aqueous slurry) in 1:1 tetrahydrofuran:methanol (145 mL) was heated to 55° C. Hydrazine monohydrate was added in four equal portions (2.7 mL each) at 0.5 h intervals. The mixture was cooled, then filtered through a small pad of silica gel using ether. The filtrate was dried over magnesium sulfate, filtered, concentrated in vacuo, and the residue purified by flash chromatography to afford 4-benzyloxy-1H-indole as a low melting solid. 
     6a. 4-Methoxy-1H-indole-3-carboxylic Acid ##STR58## 
     To a solution of 4-methoxy-1H-indole (7.15 g, 49 mmol) and pyridine (19.7 mL, 243 mmol) in dichloromethane (50 mL) at 0° C. under nitrogen was added dropwise a solution of trichloroacetyl chloride (27.1 mL, 243 mmol) in dichloromethane (50 mL). After stirring at 0° C. for an additional 1.5 h, the mixture was concentrated in vacuo. The residue was taken up in the minimal volume of methanol necessary and placed in a freezer overnight. The precipitate was filtered, rinsed well with methanol, and dried to yield 4-methoxy-3-trichloroacetyl-1H-indole. To a stirring solution of sodium methoxide (3.5 mL of a 25 weight % solution in methanol) in methanol (200 mL) at ambient temperature was added 4-methoxy-3-trichloroacetyl-1H-indole (9.07 g, 31.0 mmol) in portions over 0.75 h. After stirring an additional 0.75 h, the mixture was cooled in an ice bath, diluted with ice water, acidified with concentrated hydrochloric acid, and the methanol removed in vacuo. The resulting heterogeneous mixture was cooled in an ice bath, the precipitate filtered, rinsed with water, and dried to afford methyl 4-methoxy-1H-indole-3-carboxylic ester. A slurry of this ester (5.6 g 27 mmol) in 50% aqueous sodium hydroxide (50 mL) and methanol (50 mL) was stirred at ambient temperature for 19 h. The mixture was cooled in an ice bath, acidified with concentrated hydrochloric acid, the precipitate filtered, rinsed with ice water, and dried to afford 4-methoxy-1H-indole-3-carboxylic acid. 
     6b. 4-Benzyloxy-1H-indole-3-carboxylic acid was prepred in the same manner as 4-methoxy-1H-indole-3-carboxylic acid in 6a above. 
     7. 2-Cycloheptenone Ethylene Ketal ##STR59## 
     Bromine (44.8 g, 0.28 mol) was added dropwise to a stirred solution of cycloheptanone (28.5 g, 0.25 mol) in a 1:1 solution (300 mL) of ethylene glycol and tetrahydrofuran at room temperature. The mixture was stirred for 5 hours, then poured into aqueous sodium bicarbonate and extracted 3X with diethyl ether. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 2-bromocycloheptanone ethylene ketal(60 g). A mixture of this crude bromo ketal and a methanolic solution of sodium methoxide (250 mL, 25 wt. % solution) was heated at reflux overnight. The mixture was cooled to ambient temperature, poured into water, and extracted with hexanes. The organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to afford 2-cycloheptenone ethylene ketal (39 g). 
     8. 1,3-Cycloheptadione ##STR60## 
     Mercury (II) acetate (80.7 g, 0.25 mol) was dissolved in water (150 mL), then tetrahydrofuran (150 mL) was added to give a suspension. To this stirring suspension was added 2-cycloheptenone ethylene ketal (39 g, 0.25 mol). After stirring at ambient temperature for 3 hours, the mixture was cooled in an ice water bath. A 10% aqueous sodium hydroxide solution (150 mL) was added, followed by a solution of sodium borohydride (4.8 g, 0.13 mol) in 10% aqueous sodium hydroxide (150 mL). The mixture was allowed to reach ambient temperature and stirred overnight. The mixture was saturated with sodium chloride, stirred for 30 minutes, then allowed to settle; the solution was decanted into brine and extracted with ethyl acetate, dried over sodium sulfate, filtered, and concentrated in vacuo to give 3-Hydroxycycloheptanone ethylene ketal (36 g). 
     To a solution of this crude hydroxy ketal and triethylamine (88.3 mL, 0.63 mol) in dichloromethane (250 mL) at 0° C. was added, in one portion, sulfur trioxide pyridine complex (98.4 g, 0.63 mol) in methyl sulfoxide (250 mL). The mixture was allowed to ambient temperature, stirred for 1 hour, then cooled in an ice water bath. Brine was added, and the mixture extracted with diethyl ether. The organic layer was washed with aqueous 2N hydrochloric acid then brine, dried over magnesium sulfate, filtered, and concentrated in vacuo to give 1,3-cycloheptadione monoethylene ketal (32 g). A solution of this crude ketal in aqueous 2N hydrochloric acid (200 mL) and tetrahydrofuran (200 mL) was stirred at ambient temperature for 20 hours. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate then brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 1,3-cycloheptadione (16 g). 
     9. Ethyl 3-hydroxy-4-oxo-2,3,5,6,7,8-hextahydro-4H-cyclohepta b!furan-3-carboxylate ##STR61## 
     Ethyl bromopyruvate (26 g, 0.13 mol) was added dropwise to a stirred mixture of 1,3-cycloheptadione (16 g, 0.13 mol) and potassium carbonate (35 g, 0.25 mol) in dichloromethane (200 mL). After stirring overnight at ambient temperature, the solvent was removed in vacuo, diethyl ether was added and the mixture filtered through Celite. The filtrate was concentrated in vacuo to give the title compound (17 g). 
     10. Ethyl 4-oxo-5,6,7,8-tetrahydro-4H-cyclohepta b!furan-3-carboxylate ##STR62## 
     Methanesulfonyl chloride (9.7 g, 0.08 mol) was added dropwise to a stirring solution of ethyl 3-hydroxy-4-oxo-2,3,5,6,7,8-hexahydro-4H-cyclohepta b!furan-3-carboxylate (17 g, 0.07 mol) and triethylamine (30 mL, 0.21 mol) in dichloromethane (100 mL) at 0° C. The mixture was allowed to reach ambient temperature, stirred for 2 hours, then poured into water and extracted with dichloromethane. The organic layer was washed sequentially with aqueous 2N sodium hydroxide, saturated aqueous sodium bicarbonate, and brine, then dried over magnesium sulfate, filtered, concentrated in vacuo, and purified on Silica gel (1:1 ethyl acetate/hexanes) to give the title compound. 
     11. 4-Oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxylic Acid ##STR63## 
     A mixture of ethyl 4-oxo-5,6,7,8-tetrahydro-4H-cyclohepta b!furan-3-carboxylate (3.48 g,15.7 mmol) and ammonium acetate (2.41 g, 31.3 mmol) in N,N-dimethylformamide (25 mL) was heated at 115° C. for 6 hours. The mixture was concentrated in vacuo, ice water was added, and extracted 2X with dichloromethane. The combined organic layers were washed with saturated aqueous sodium bicarbonate then brine, dried over sodium sulfate, filtered through a small pad of Silica gel (5% methyl alcohol/dichloromethane), and the filtrate concentrated in vacuo to give ethyl 4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxylate (1.76 g). A solution of this ester in aqueous 5N sodium hydroxide (30 mL) and ethyl alcohol(6 mL) was heated at reflux for 1 hour, then cooled in an ice bath. The mixture was acidified with hydrochloric acid; the resulting precipitate was collected, rinsed with water followed by diethyl ether and allowed to dry to give 4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxylic acid (1.17 g). m.p.  225 °-227° C. 
     12. Ethyl N-ethyl, N-(3-methoxycarbonyl)propyl Malonamide ##STR64## 
     A solution of methyl acrylate (54 mL, 0.6 mol) in methyl alcohol (500 mL) was added dropwise to a stirred solution of ethylamine (340 mL, 6 mol) in methyl alcohol (1.5 L) at 0° C. After stirring an additional 45 minutes, the mixture was distilled in vacuo into one pot, then the solvent removed in vacuo (temperature &lt;35° C.). To the residue dissolved in dichloromethane (400 mL) at 0° C. was added triethylamine (62.5 mL, 448 mmol) followed by a solution of ethyl malonyl chloride (54.4 mL, 427 mmol) in dichloromethane (100 mL). The mixture was stirred for 1 hour, then poured into saturated aqueous ammonium chloride and extracted with dichloromethane. The organic layer was washed with saturated aqueous sodium bicarbonate then water, dried over magnesium sulfate, filtered, and concentrated in vacuo to give the title compound (87.55 g). 
     13. N-Ethyl-2,4-piperidione ##STR65## 
     A solution of ethyl N-ethyl, N-(3-methoxycarbonyl)propyl malonamide (87.55 g, 357 mmol) in methyl alcohol (350 mL) was added dropwise to a methanolic solution of sodium methoxide (25 wt. %, 163 mL) at ambient temperature. After heating at reflux for 1.5 hours, the reaction mixture was allowed to cool and concentrated in vacuo. After cooling the residue in an ice water bath, aqueous hydrochloric acid was added and extracted 2X with ethyl acetate, dried over magnesium sulfate, filtered, and concentrated in vacuo to give N-ethyl-3-methoxycarbonyl-2,4-piperidione (64.4 g). Some of this dione (57 g, 286 mmol) was heated at reflux in a mixture of hydrochloric acid (36 mL) and water (364 mL) for 3.5 hours. After cooling to ambient temperature, the solution was extracted 3X with ethyl acetate, the combined organic layer dried over magnesium sulfate, filtered, and concentrated in vacuo to give the title compound (9.54 g). 
     14. Ethyl 4-oxo-5-ethyl-4,5,6,7-tetrahydrofuro 3,2-c!pyridine-3-carboxylate ##STR66## 
     To a stirred solution of potassium hydroxide (3.79 g, 67.6 mmol) in methyl alcohol (15 mL) under Nitrogen at 0° C. was added dropwise a solution of N-ethyl-2,4-piperidione (9.54 g, 67.6 mmol) in methyl alcohol (20 mL). The mixture was stirred at 0° C. for 1 hour, then a solution of ethyl bromopyruvate (8.9 mL, 71 mmol) in methyl alcohol(50 mL) was added dropwise. After allowing the mixture to stir at ambient temperature for 2.5 hours, a 50% aqueous sodium hydroxide solution (10 mL) was added dropwise and stirring continued an additional 17 hours. After cooling in an ice water bath, the solution was acididfied and the methanol removed in vacuo. Ice water was added and the precipitate filtered and dried in vacuo to afford 4-oxo-5-ethyl-4,5,6,7-tetrahydrofuro 3,2-c!pyridine-3-carboxylic acid (3.91 g). More acid (1.15 g) was obtained via extraction of the aqueous filtrate 2X wtih ethyl acetate, drying over magnesium sulfate, filtration, concentrating in vacuo, and purification on Silica gel (5% methyl alcohol/dichloromethane). A stirring mixture of 4-oxo-5-ethyl-4,5,6,7-tetrahydrofuro 3,2-c!pyridine-3-carboxylic acid (4.94 g, 23.6 mmol), potassium carbonate (9.79 g, 70.8 mmol), cesium carbonate (770 mg, 2.4 mmol), and iodoethane (9.4 mL, 118 mmol) in N,N-dimethylformamide was heated at 85° C. for 15.5 hours. The reaction mixture was cooled and concentrated in vacuo. Ethyl acetate was added, the mixture filtered, the filtrate washed with water, and the organic layer dried over magnesium sulfate, filtered, and concentrated in vacuo to give the title compound (4.5 g). 
     15. 4-Oxo-5-ethyl-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxylic Acid ##STR67## 
     A mixture of ethyl 4-oxo-5-ethyl-4,5,6,7-tetrahydrofuro 3,2-c!pyridine-3-carboxylate (3.66 g, 15.4 mmol) and ammonium acetate (5.94 g, 77.1 mmol) in N,N-dimethylformamide (30 mL) was heated at 115° C. for 23 hours. The mixture was cooled, concentrated in vacuo, ice water added, and the precipitate collected and dried to give ethyl 4-oxo-5-ethyl-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxylate (1.95 g). The aqueous filtrate was extracted 2X with ethyl acetate, the combined organic layers dried over magnesium sulfate, filtered, and concentrated in vacuo to afford additional ester (0.68 g). The combined materials were treated with aqueous 5N sodium hydroxide (75 mL) in dioxane (10 mL) at reflux for 2 hours. After cooling in an ice water bath, the mixture was acidified with aqueous hydrochloric acid, and concentrated in vacuo. Ethyl acetate was added, the mixture filtered, and the organic layer concentrated in vacuo. Trituration with ethyl acetate afforded 4-oxo-5-ethyl-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxylic acid (0.84 g). 
     16. 2-Nitro-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic Acid ##STR68## 
     4-Oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (179 mg, 1 mmol) was added in portions over 30 minutes to fuming nitric acid (2 mL) at 0° C. The mixture was stirred an additonal 1.25 hours, then allowed to stir at ambient temperature for 1.25 hours. The mixture was poured into ice water and extracted 2X with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated in vacuo to give the title compound(0.19 g). 
     17. 2-Bromo-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic Acid ##STR69## 
     To a solution of 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (886 mg, 5 mmol) and catalytic benzoyl peroxide in N,N-dimethylformamide (5 mL) at 0° C. was added N-bromosuccinimide (1.869 g, 10.5 mmol)in four equal portions over 1 hour. The mixture was stirred an additional hour, then poured into ice water, the precipitate collected and rinsed with water then diethyl ether and dried. Purification on Silica gel (5% methyl alcohol in 1:1:1 dichloromethane/ethyl acetate/hexanes) gave 2-bromo-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (376 mg). 
     EXAMPLE 2 ##STR70## 
     A mixture of 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (179 mg, 1 mmol), p-anisidine (616 mg, 5 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride  EDCI! (959 mg, 5 mmol) in 50% aqueous 1,4-dioxane (10 mL) was stirred at ambient temperature for 17 h. After concentrating in vacuo, the residue was taken up in 10% methanol in ethyl acetate, washed with 1.3M hydrochloric acid then with aqueous sodium bicarbonate, dried over magnesium sulfate, filtered, and concentrated in vacuo. Recrystallization from ethyl acetate afforded N-(4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 1); mp 219°-220° C. 
     EXAMPLE 3 ##STR71## 
     N-(2-Fluoro-4-methoxyphenyl)-4-benzyloxy-1H-indole-3-carboxamide (1.34 g, 3.4 mmol), prepared using the method above, was slurried with 10% palladium on carbon (134 mg) in ethanol (35 mL) in a Parr bottle and placed under a hydrogen atmosphere (50 psi) for 5 h. Methanol (5 ml) was added and the mixture returned to the Hydrogen atmosphere for an additional 18 h. The solution was filtered through Celite, concentrated in vacuo, and the residue purified by flash chromatography to afford N-(2-fluoro-4-methoxyphenyl)-4-hydroxy-1H-indole-3-carboxamide (Compound 2) as a beige solid; mp 259°-261° C. (d). 
     EXAMPLE 4 
     The following compounds were prepared essentially according to the procedures described in Examples 1-3: 
     (a) N-(4-Ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 3); mp 217°-218° C. 
     (b) N-(4-Ethoxyphenyl)-4-methoxy-1H-indole-3-carboxamide (Compound 4); mp 259°-261° C. (d). 
     (c) N-(3-Ethoxyphenyl)-4-methoxy-1H-indole-3-carboxamide (Compound 5). 
     (d) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 6). 
     (e) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 7). 
     (f) N-(4-Methoxyphenyl)-4-methoxy-1H-indole-3-carboxamide (Compound 8). 
     (g) N-(2-Fluoro-4-ethoxyphenyl)-4-methoxy-1H-indole-3-carboxamide (Compound 9). 
     (h) N-(4-Cyanophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 10); mp 287°-288° C. 
     (i) N-(3-Methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 11); mp 220°-223° C. 
     (j) N-(4-Acetamidophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 12); mp 339°-341° C. 
     (k) N-(4-Chlorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 13). 
     (l) N-(2-Fluoro-4-methoxyphenyl)-4-benzyloxy-1H-indole-3-carboxamide (Compound 14). 
     (m) N-(4-Acetylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 15). 
     (n) N-(2-Fluoro-5-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 16). 
     (o) N-(4-Carbomethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 17); mp 261°-262° C. 
     (p) N-(4-Carboxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 18). 
     (q) N-(4-Ethoxyphenyl)-4-hydroxy-1H-indole-3-carboxamide (Compound 19). 
     (r) N-(3-Ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 20). 
     (s) N-(2-Fluoro-4-methoxyphenyl)-4-benzyloxy-1H-indole-3-carboxamide (Compound 21). 
     (t) N-(4-Isopropoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 22). 
     (u) N-(4-Fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 23). 
     (v) N-(4-Hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 24). 
     (w) N-(4-Aminophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 25). 
     (x) N-(3-Fluoro-4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 26); mp: 230°-232° C. ##STR72## (z) N-(2-Fluoro-4-isopropoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 28). 
     (aa) N-( 4  -Fluorophenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 29). 
     (ab) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 30); mp 193°-194° C. 
     (ac) N-(4-Ethoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 31). 
     (ad) N-(4-Methoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 32). 
     (ae) N-(2-Methoxy-5-bromophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 33). 
     (af) N-(3,4-Dihydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 34). 
     (ag) N-Phenyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 35) (Also, see Example 5). 
     (ah) N-(2-Fluoro-4-hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 36). 
     (ai) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 37). 
     (aj) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 38). 
     (ak) N-(4-Ethoxyphenyl)-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 39). 
     (al) N-(4-Methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 40). 
     (am) N-(3-Methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 41). 
     (an) N-(2-Amino-4-methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 42). 
     (ao) N-(4-Methylaminophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 43). 
     (ap) N-Phenyl-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 44). 
     (aq) N-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 45). 
     (ar) N-(2-Fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 46). 
     (as) N-(3-Fluorophenyl)-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 47). 
     (at) N-(2-(4-Hydroxyphenyl)ethyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 48). 
     (au) N-(2-(4-Ethoxyphenyl)ethyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 49). 
     (av) N-(4-Ethoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 50). 
     (aw) N-(2-Fluorophenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 51). 
     (ax) N-Phenyl-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 52). 
     (ay) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 53). 
     (az) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 54). 
     (ba) N-(4-Fluoro-2-hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 55). 
     EXAMPLE 5 ##STR73## 
     A mixture of 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (179 mg, 1 mmol), aniline (0.46 mL, 5 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (959 mg, 5 mmol) in 50% aqueous dioxane (10 mL) was allowed to stir at ambient temperature for 17.5 hours, then concentrated in vacuo. The residue was cooled in an ice water bath, aqueous 3.6N hydrochloric acid was added, and the precipitate collected, rinsed with aqueous 3.6N hydrochloric acid then water and dried. Recrystallization from ethyl alcohol afforded N-phenyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 35) (164 mg). mp 225°-226° C. 
     EXAMPLE 6 ##STR74## 
     To a solution of 4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (538 mg, 3 mmol) and triethylamine (0.88 mL, 6.3 mmol) in N,N-dimethylformamide (15 mL) at 0° C. was added ethyl chloroformate (0.57 mL, 6 mmol). After stirring at 0° C. for 45 minutes, 2-fluoroaniline (0.58 mL, 6 mmol) wad added. The mixture was stirred for an additional 45 minutes, then allowed to stir at ambient temperature for 14 hours. The mixture was poured into aqueous 1.2N hydrochloric acid and extracted 2X with ethyl acetate. The combined organic layers were washed with water, dried over magnesium sulfate, filtered, and concentrated in vacuo. To the residue was added aqueous 1N sodium hydroxide (10 nL) and ethyl alcohol (2 mL) and the mixture heated at reflux for 4.5 hours. After cooling in an ice water bath, the mixture was acidified with aqueous hydrochloric acid, the precipitate collected, rinsed with water and dried. Recrystallization from ethyl alcohol afforded N-(2-fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 46) (530 mg). mp 238°-240° C. 
     EXAMPLE 7 ##STR75## 
     A mixture of 2-nitro-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (0.18 g, 0.8 mmol), p-phenetidine (0.52 mL, 4 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (767 mg, 4 mmol) in 50% aqueous dioxane (10 mL) was stirred for 67 hours, then concentrated in vacuo. Aqueous 3.6N hydrochloric acid was added, the mixture cooled in an ice water bath, and the precipitate collected, rinsed with water then diethyl ether, and dried. Purification on Silica gel (10% methyl alcohol/dichloromethane) gave N-(4-ethoxyphenyl)-2-nitro-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 56) (51 mg). 
     EXAMPLE 8 ##STR76## 
     N-(4-Ethoxyphenyl)-2-nitro-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (41 mg) was treated with 10% palladium on carbon (5 mg) in ethyl alcohol (10 mL) under hydrogen (50 PSI) in a Parr bottle for 1 hour. The mixture was filtered through Celite, concentrated in vacuo, and purified on Silica gel (5% methyl alcohol/dichloromethane) to afford N-(4-ethoxyphenyl)-2-amino-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 57) (12 mg). 
     EXAMPLE 9 ##STR77## 
     A mixture of N-(4-ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (204 mg, 0.7 mmol), potassium carbonate (188 mg, 1.4 mmol), cesium carbonate (22 mg, 0.1 mmol), and iodoethane (0.08 mL, 1 mmol) in N,N-dimethylformamide was heated at 85° C. for 1 hour. The mixture was cooled and filtered using ethyl acetate. The solid was set aside; the organic layer was washed with water, dried over magnesium sulfate, filtered, concentrated in vacuo, and triturated with diethyl ether to give N-(4-ethoxyphenyl)-1-ethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (73 mg). The set-aside solid was slurried in aqueous hydrochloric acid, the precipitate collected, rinsed with water and dried to give additional amide (Compound 58) (94 mg). mp. 209°-210° C. 
     EXAMPLE 10 
     The following compounds are prepared essentially according to the procedures described in Examples 1-9: 
     (a) N-(3-Fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 59); mp 235°-237° C. 
     (b) N-(4-Fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 60); mp259°-261° C. 
     (c) N-(2-Hydroxy-4-fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 61); mp 252°-254° C. 
     (d) N-(2-Hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 62); mp 215°-216° C. 
     (e) N-(4-Hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 63); mp 313°-315° C. 
     (f) N-(2-Fluoro-4-hydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 64); mp 335°-338° C. (d). 
     (g) N-(3,4-Dihydroxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 65). 
     (h) N-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 66 mp 328°-331° C. (d). 
     (i) N-(3-Ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 67); mp 227°-228° C. 
     (j) N-(2-Fluoro-4-isopropoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 68); mp 216°-217° C. 
     (k) N-(3-Methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 69). 
     (l) N-(2-Fluoro-5-methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 70); mp 223°-225° C. 
     (m) N-(4-Methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 71); mp 220°-222° C. 
     (n) N-(2-Fluoro-4-methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 72); mp 181°-183° C. 
     (o) N-(2-Hydroxy-4-methylphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 73); mp 238°-240° C. 
     (p) N- 4-(Methylamino)phenyl!-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 74); mp 242°-244° C. 
     (q) N-(4-Aminophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 75); mp 207°-210° C. 
     (r) N-(3-Chlorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 76). 
     (s) N-(2-Hydroxy-4-chlorophenyl)-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 77); mp 190°-195° C. 
     (t) N-(4-Ethoxyphenyl)-2-bromo-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 78). 
     (u) N-(4-Ethoxyphenyl)-2-chloro-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 79). 
     (v) N-Phenyl-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 80); mp 248°-251° C. 
     (w) N-(2-Fluorophenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 81); mp 214°-216° C. 
     (x) N-(3-Fluorophenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 82); mp 247°-249° C. 
     (y) N-(4-Fluorophenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 83). 
     (z) N-(3-Methoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 84). 
     (aa) N-(3-Methylphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 85); mp 233°-234° C. 
     (ab) N-(4-Hydroxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 86); mp 301°-303° C. 
     (ac) N-(2-Fluoro-4-hydroxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 87); mp 340° C. 
     (ad) N-(4-Methoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 88). 
     (ae) N-(2-Fluoro-5-methoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 89). 
     (af) N-(4-Ethoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 90). 
     (ag) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-5,5-dimethyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 91); mp 178°-180° C. 
     (ah) N-Phenyl-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 92); mp 218°-219° C. 
     (ai) N-(2-Fluorophenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 93). 
     (aj) N-(3-Fluorophenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 94). 
     (ak) N-(4-Fluorophenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 95). 
     (al) N-(3-Methoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 96); mp 190° C. 
     (am) N-(4-Hydroxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 97); mp 278°-280° C. 
     (an) N-(4-Methoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 98); mp 178°-179° C. 
     (ao) N-(4-Ethoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 99); mp 198°-201° C. 
     (ap) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 100); mp 158°-159° C. 
     (aq) N-(2-Fluoro-4-hydroxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 101); mp 305°-308° C. 
     (ar) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 102); mp 172°-174° C. 
     (as) N-(2-Fluoro-5-methoxyphenyl)-4-oxo-1,4,5,6,7,8-hexahydro-cyclohepta b!pyrrole-3-carboxamide (Compound 103). 
     (at) N-(2-Fluoro-4-methoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxamide (Compound 104); mp 150°-152° C. 
     (au) N-(4-Ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxamide (Compound 105); mp 145°-147° C. 
     (av) N-(2-Fluoro-4-ethoxyphenyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo 3,2-c!pyridine-3-carboxamide (Compound 106); mp 154°-155° C. 
     (aw) N-(4-Ethoxyphenyl)-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 107); mp 215°-216° C. 
     (ax) N-(4-Ethoxyphenyl)-1-ethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide (Compound 108); mp 209°-210° C. 
     The invention and the manner and process of making and using it, are now described in such full, clear, concise and exact terms as to enable any person skilled in the art to which it pertains, to make and use the same. It is to be understood that the foregoing describes preferred embodiments of the present invention and that modifications may be made therein without departing from the spirit or scope of the present invention as set forth in the claims. To particularly point out and distinctly claim the subject matter regarded as invention, the following claims conclude this specification.