Abstract:
An apparatus and method reduces the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of the lung. A lace, carried by the jacket, collapses the jacket about the lung portion. The jacket may further include a drawstring circumscribing the jacket at the base for closing the open base of the jacket about the lung portion. The collapsing of the jacket may be employed for both reducing the size of the lung and maintaining the lung in a reduced size condition or the lung portion may be deflated prior to the placement of the jacket over the lung portion, in which case, the jacket serves to prevent re-expansion of the lung portion.

Description:
BACKGROUND OF THE INVENTION  
         [0001]    The present invention is generally directed to an apparatus and method for treating Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to such an apparatus and method which may be implanted in the human body to provide lung size reduction by constricting at least a portion of a lung.  
           [0002]    Chronic Obstructive Pulmonary Disease (COPD) has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.  
           [0003]    The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991 COPD was the fourth leading cause of death in the United States and had increased 33% since 1979.  
           [0004]    COPD affects the patient&#39;s whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking up hill. Later, it may be noticed when simply walking in the kitchen. Overtime, it may occur with less and less effort until it is present all of the time.  
           [0005]    COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.  
           [0006]    The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary.  
           [0007]    Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled ∃-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, Ipratropium bromide may be indicated. Further, courses of steroids, such as corticosterocds, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pheumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.  
           [0008]    About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the procedure was abandoned.  
           [0009]    The lung volume reduction surgery (LVRS) was later revived. In the early 1990&#39;s, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor due to the fact that Medicare stopped remitting for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life.  
           [0010]    Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling.  
           [0011]    Lastly, lung tranplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.  
           [0012]    In view of the foregoing, there in a need in the art for a new and improved therapy for COPD. More specifically, there is a need for such a therapy which provides more permanent results than pharmacotherapy while being less traumatic than LVRS. The present invention is directed to an apparatus and method which provide such an improved therapy for COPD.  
         SUMMARY OF THE INVENTION  
         [0013]    The present invention provides an implantable apparatus for reducing the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of a lung and collapsing means carried by the jacket for collapsing the jacket about the lung portion.  
           [0014]    The invention still further provides a method of reducing the size of a lung. The method includes the steps of disposing a jacket of flexible fabric over at least a portion of a lung. The collapsing of the jacket may serve to both reduce the size of the lung and maintain it in its reduced size condition. Alternatively, the lung portion may first be deflated whereupon the collapsed jacket serves to maintain the lung portion in a deflated, reduced size condition. 
       
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       [0015]    The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify identical elements, and wherein:  
         [0016]    [0016]FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system;  
         [0017]    [0017]FIG. 2 is a sectional view similar to FIG. 1 but illustrating a respiratory system suffering from COPD;  
         [0018]    [0018]FIG. 3 is a perspective view illustrating a lung constriction apparatus embodying the present invention;  
         [0019]    [0019]FIG. 4 is a sectional view of the respiratory system of FIG. 2 with a lung constriction apparatus embodying the present invention being disposed over a lung portion to be reduced in size;  
         [0020]    [0020]FIG. 5 illustrates an initial step in collapsing the lung constricting apparatus about the lung portion;  
         [0021]    [0021]FIG. 6 illustrates a further step in collapsing the lung constriction apparatus;  
         [0022]    [0022]FIG. 7 illustrates the lung constricting apparatus being fully collapsed about the lung portion; and  
         [0023]    [0023]FIG. 8 illustrates the respiratory system after both left and right side lung portions have been reduced in size in accordance with the present invention. 
     
    
     DETAILED DESCRIPTION  
       [0024]    Referring now to FIG. 1, it is a sectional view of a healthy respiratory system. The respiratory system  20  resides within the thorax  22  which occupies a space defined by the chest wall  24  and the diaphragm  26 .  
         [0025]    The respiratory system  20  includes the trachea  28 , the left mainstem bronchus  30 , the right mainstem bronchus  32 , and the bronchial branches  34 ,  36 ,  38 ,  40 , and  42 . The respiratory system  20  further includes left lung lobes  52  and  54  and right lung lobes  56 ,  58 , and  60 . Each bronchial branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.  
         [0026]    Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm  26 . As the individual inhales, the diaphragm  26  straightens to increase the volume of the thorax  22 . This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.  
         [0027]    In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the lung lobes  52 ,  54 ,  56 ,  58 , and  60  are enlarged and that the diaphragm  26  is not arched but substantially straight. Hence, this individual is incapable of breathing normally by moving the diaphragm  28 . Instead, in order to create the negative pressure in the thorax  22  required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.  
         [0028]    It has been found that the apex portion  62  and  66  of the upper lung lobes  52  and  56 , respectively, are most affected by COPD. Hence, the preferred embodiment will be described for treating the apex  66  of the right, upper lung lobe  56 . However, as will be appreciated by those skilled in the art, the present invention may be applied to any lung portion without departing from the present invention.  
         [0029]    The apparatus and method of the present invention treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing lung volume reduction surgery. As will be seen hereinafter, the present invention contemplates permanent collapse of a lung portion or lung portions most affected. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.  
         [0030]    Referring now to FIG. 3, it illustrates a lung constriction apparatus  70  embodying the present invention. The apparatus  70  takes the form of a jacket  72  formed of a flexible fabric such as an open mesh of polyester. The jacket includes an open base  74  and a curved surface  76  extending from the open base  74  and terminating in a closed, domed-shape end or apex  78 . The open base  74  is dimensioned to be applied over and to cover the lung portion to be reduced in size.  
         [0031]    The constriction apparatus  70  further includes at least one lace  80  extending from the apex  78  to the base  74 . The cord  82  forming the lace  80  has a pair of free ends  84  and  86  which are threaded through a guide tube  88  from the distal end  90  of the guide tube  88  to the proximal end  92  of the guide tube  88 .  
         [0032]    The guide tube  88  serves to maintain the free ends  84  and  86  of the cord  82  together. When the free ends  84  and  86  of the cord  82  are drawn while holding the guide tube distal end  90  adjacent the base  74 , the jacket  72  is collapsed to reduce the inner volume of the jacket. This constriction of the jacket serves to collapse the jacket about the lung portion to be reduced in size.  
         [0033]    As will be seen hereinafter, a plurality of laces may be carried by the jacket. As each lace is drawn, the jacket will be collapsed to a greater and controlled extent.  
         [0034]    The jacket  72  further includes a piping  94  at the base  74 . A draw string  96  is threaded through the piping to circumscribe the jacket  72  and the base  74 . The draw string has a pair of free ends  98  and  100 . As will be seen hereinafter, after the laces are drawn to collapse the jacket  72  about the lung portion, the free ends  98  and  100  of the draw string  96  may be pulled and drawn to close the open base  74  of the jacket  72  about the lung portion. This will provide additional constriction to assure that the lung portion does not reinflate. It also serves to cut off all blood circulation to the lung portion. This promotes infarction and fibrosis.  
         [0035]    Referring now to FIG. 4, it illustrates the constriction device  70  after it has been placed over the apex of the upper right lung lobe  56  to cover the lung portion  66  of the right upper lobe  56  referred to previously with respect to FIG. 2. The jacket  72  covers the lung portion  66 . At this point, the free ends  84  and  86  of the cord forming the lace  80  have not been drawn.  
         [0036]    Referring now to FIG. 5, here it may be seen that the lace  80  has been drawn by the pulling of the free ends  84  and  86  of the lace cord while holding the guide tube  88  such that its distal end  90  is closely adjacent the base  74  of the jacket  72 . As will be observed in FIG. 5, because the jacket  72  has been collapsed about the lung portion  66  of the upper lobe  56 , the lung portion  66  has been reduced in size due to the constriction of the jacket  72 .  
         [0037]    [0037]FIG. 6 illustrates the jacket  72  with additional laces  110  and  112  which have also been drawn. When the laces are drawn tightly, the free ends of the cords forming the laces may be tied off and then cut as illustrated. The lung portion  66  of the upper right lobe  56  is now more fully reduced in size by the constriction of the jacket  72 .  
         [0038]    [0038]FIG. 7 illustrates the further constriction provided by the drawstring after being pulled. The free ends of the drawstring after being pulled may be then tied together and cut as illustrated. As can be seen in FIG. 7, the lung portion  66  of the upper right lobe  56  has been drastically reduced in size. Further, the drawstring constriction will cut off circulation to the lung portion  66  to promote infarction and fibrosis.  
         [0039]    [0039]FIG. 8 illustrates the respiratory system after both the lung portion  66  of the upper right lobe  56  and the lung portion  62  of the upper left lobe  52  have been treated as described above. Here it can be seen that the volumes of the right upper lung lobe  56  and left upper lung lobe  52  have been reduced in size by the jacket  72 . This causes the lung lobes to occupy less volume within the thorax  22  to permit the diaphragm  26  to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.  
         [0040]    As can thus be seen from the foregoing, the present invention provides an apparatus and method for treating COPD by lung volume reduction. The lung volume reduction is achieved through the permanent collapsing of one or more lung portions, or lobes, or portions of lobes. The foregoing is achieved without the need for removing lung tissue. Following the treatment, the lung tissue within the thorax will occupy a lesser volume than previously occupied providing room for the diaphragm to assume its arcuate state to assist in normal breathing and to achieve the benefits of lung volume reduction.  
         [0041]    While particular embodiments of the present invention have been shown and described, modifications may be made. For example, while the jacket may be employed for reducing the size of a lung by constriction, the invention is not intended to be so limited. Rather, the lung portion may become deflated during surgery on its own or by other means known in the art. The jacket may then be placed on the lung portion while it is in a deflated condition. The jacket may then be collapsed about the lung portion to cinch down over the lung to maintain it in its deflated, reduced volume condition. The jacket would thus prevent re-expansion of the captured lung portion. The remaining portions of the lung may then be expanded, if necessary, by means known in the art. Hence, it is intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.