Abstract:
The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

Description:
RELATED APPLICATIONS 
   This application is a division of U.S. Ser. No. 09/779,078 filed Feb. 8, 2001 now U.S. Pat. No. 6,596,022, which is a division of U.S. Ser. No. 09/561,098 filed Apr. 28, 2000 now U.S. Pat. No. 6,309,412, which is a division of U.S. Ser. No. 09/135,222 filed Aug. 17, 1998 now U.S. Pat. No. 6,056,776, which is a division of U.S. Ser. No. 09/055,582 filed Apr. 6, 1998 now U.S. Pat. No. 6,066,168, which is a division of U.S. Ser. No. 08/783,097 filed Jan. 14, 1997, now U.S. Pat. No. 5,735,893, which is a division of U.S. Ser. No. 08/556,516, filed Nov. 13, 1995, now U.S. Pat. No. 5,603,721, which is a division of U.S. Ser. No. 08/281,790, filed Jul. 28, 1994, now U.S. Pat. No. 5,514,154, which is a continuation in part of U.S. Ser. No. 08/164,986 filed Dec. 9, 1993, now abandoned, which is a continuation of Ser. No. 07/783,558, filed Oct. 28, 1991, now abandoned. 

   BACKGROUND OF THE INVENTION 
   This invention relates to expandable endoprosthesis devices, generally called stents, which are adapted to be implanted into a patient&#39;s body lumen, such as blood vessel, to maintain the patency thereof. These devices are very useful in the treatment of atherosclerotic stenosis in blood vessels. 
   Stents are generally tubular-shaped devices which function to hold open a segment of a blood vessel or other anatomical lumen. They are particularly suitable for use to support and hold back a dissected arterial lining which can occlude the fluid passageway therethrough. 
   Further details of prior art stents can be found in U.S. Pat. No. 3,868,956 (Alfidi et al.); U.S. Pat. No. 4,512,338 (Balko et al.); U.S. Pat. No. 4,553,545 (Maass et al.); U.S. Pat. No. 4,733,665 (Palmaz); U.S. Pat. No. 4,762,128 (Rosenbluth); U.S. Pat. No. 4,800,882 (Gianturco); U.S. Pat. No. 4,856,516 (Hillstead); and U.S. Pat. No. 4,886,062 (Wiktor), which are hereby incorporated herein in their entirety by reference thereto. 
   Various means have been described to deliver and implant stents. One method frequently described for delivering a stent to a desired intraluminal location includes mounting the expandable stent on an expandable member, such as a balloon, provided on the distal end of an intravascular catheter, advancing the catheter to the desired location within the patient&#39;s body lumen, inflating the balloon on the catheter to expand the stent into a permanent expanded condition and then deflating the balloon and removing the catheter. One of the difficulties encountered using prior stents involved maintaining the radial rigidity needed to hold open a body lumen while at the same time maintaining the longitudinal flexibility of the stent to facilitate its delivery. 
   What has been needed and heretofore unavailable is a stent which has a high degree of flexibility so that it can be advanced through tortuous passageways and can be readily expanded and yet have the mechanical strength to hold open the body lumen into which it expanded. The present invention satisfies this need. 
   SUMMARY OF THE INVENTION 
   The present invention is directed to an expandable stent which is relatively flexible along its longitudinal axis to facilitate delivery through tortuous body lumens, but which is stiff and stable enough radially in an expanded condition to maintain the patency of a body lumen such as an artery when implanted therein. 
   The stent of the invention generally includes a plurality of radially expandable cylindrical elements which are relatively independent in their ability to expand and to flex relative to one another. The individual radially expandable cylindrical elements of the stent are dimensioned so as to be longitudinally shorter than their own diameters. Interconnecting elements or struts extending between adjacent cylindrical elements provide increased stability and a preferable position to prevent warping of the stent upon the expansion thereof. The resulting stent structure is a series of radially expandable cylindrical elements which are spaced longitudinally close enough so that small dissections in the wall of a body lumen may be pressed back into position against the lumenal wall, but not so close as to compromise the longitudinal flexibilities of the stent. The individual cylindrical elements may rotate slightly relative to adjacent cylindrical elements without significant deformation, cumulatively giving a stent which is flexible along its length and about its longitudinal axis but is still very stiff in the radial direction in order to resist collapse. 
   The stent embodying features of the invention can be readily delivered to the desired lumenal location by mounting it on an expandable member of a delivery catheter, for example a balloon, and passing the catheter-stent assembly through the body lumen to the implantation site. A variety of means for securing the stent to the expandable member on the catheter for delivery to the desired location are available. It is presently preferred to compress the stent onto the balloon. Other means to secure the stent to the balloon include providing ridges or collars on the inflatable member to restrain lateral movement, or using bioresorbable temporary adhesives. 
   The presently preferred structure for the expandable cylindrical elements which form the stents of the present invention generally circumferential undulating pattern, e.g. serpentine. The transverse cross-section of the undulating component of the cylindrical element is relatively small and preferably has an apect ratio of about two to one to about 0.5 to one. A one to one apect ratio has been found particularly suitable. The open reticulated structure of the stent allows for the perfusion of blood over a large portion of the arterial wall which can improve the healing and repair of a damaged arterial lining. 
   The radial expansion of the expandable cylinder deforms the undulating pattern thereof similar to changes in a waveform which result from decreasing the waveform&#39;s amplitude and the frequency. Preferably, the undulating patterns of the individual cylindrical structures are in phase with each other in order to prevent the contraction of the stent along its length when it is expanded. The cylindrical structures of the stent are plastically deformed when expanded (except with NiTi alloys) so that the stent will remain in the expanded condition and therefore they must be sufficiently rigid when expanded to prevent the collapse thereof in use. During expansion of the stent, portions of the undulating pattern will tip outwardly resulting in projecting members on the outer surface of the expanded stent. These projecting members tip radially outwardly from the outer surface of the stent and embed in the vessel wall and help secure the expanded stent so that it does not move once it is implanted. 
   With superelastic NiTi alloys, the expansion occurs when the stress of compression is removed so as to allow the phase transformation from austenite back to martensite and as a result the expansion of the stent. 
   The elongated elements which interconnect adjacent cylindrical elements should have a transverse cross-section similar to the transverse dimensions of the undulating components of the expandable cylindrical elements. The interconnecting elements may be formed in a unitary structure with the expandable cylindrical elements from the same intermediate product, such as a tubular element, or they may be formed independently and connected by suitable means, such as by welding or by mechanically securing the ends of the interconnecting elements to the ends of the expandable cylindrical elements. Preferably, all of the interconnecting elements of a stent are joined at either the peaks or the valleys of the undulating structure of the cylindrical elements which for the stent. In this manner there is no shortening of the stent upon expansion. 
   The number and location of elements interconnecting adjacent cylindrical elements can be varied in order to develop the desired longitudinal flexibility in the stent structure both in the unexpanded as well as the expanded condition. These properties are important to minimize alteration of the natural physiology of the body lumen into which the stent is implanted and to maintain the compliance of the body lumen which is internally supported by the stent. Generally, the greater the longitudinal flexibility of the stent, the easier and the more safely it can be delivered to the implantation site. 
   In a presently preferred embodiment of the invention the stent is conveniently and easily formed by coating stainless steel tubing with a material resistant to chemical etching, removing portions of the coating to expose portions of underlying tubing which are to be removed to develop the desired stent structure. The exposed portions of the tubing are removed by chemically etching from the tubing exterior leaving the coated portion of the tubing material in the desired pattern of the stent structure. The etching process develops smooth openings in the tubing wall without burrs or other artifacts which are characteristic of mechanical or laser machining processes in the small sized products contemplated. Moreover, a computer controlled laser patterning process to remove the chemical resistive coating makes photolithography technology adaptable to the manufacture of these small products. The forming of a mask in the extremely small sizes needed to make the small stents of the invention would be a most difficult task. A plurality of stents can be formed from one length of tubing by repeating the stent pattern and providing small webs or tabs to interconnect the stents. After the etching process, the stents can be separated by severing the small webs or tabs which connect them. 
   Other features and advantages of the present invention will become more apparent from the following detailed description of the invention. When taken in conjunction with the accompanying exemplary drawings. 

   
     BRIEF DESCRIPTION OF THE DRAWINGS 
       FIG. 1  is an elevational view, partially in section, of a stent embodying features of the invention which is mounted on a delivery catheter and disposed within a damaged artery. 
       FIG. 2  is an elevational view, partially in section, similar to that shown in  FIG. 1  wherein the stent is expanded within a damaged artery, pressing the damaged lining against the arterial wall. 
       FIG. 3  is an elevational view, partially in section showing the expanded stent within the artery after withdrawal of the delivery catheter. 
       FIG. 4  is a perspective view of a stent embodying features of the invention in an unexpanded state, with one end of the stent being shown in an exploded view illustrate the details thereof. 
       FIG. 5  is a plan view of a flattened section of a stent of the invention which illustrates the undulating pattern of the stent shown in FIG.  4 . 
       FIG. 6  is a schematic representation of equipment for selectively removing coating applied to tubing in the manufacturing of the stents of the present invention. 
       FIGS. 7 through 10  are perspective views schematically illustrating various configurations of interconnective element placement between the radially expandable cylindrical elements of the stent. 
       FIG. 11  is a plan view of a flattened section of a stent illustrating an alternate undulating pattern in the expandable cylindrical elements of the stent which are out of phase. 
       FIG. 12  is an enlarged partial view of the stent of  FIG. 5  with the various members slightly expanded. 
       FIG. 13  is a perspective view of the stent of  FIG. 4  after it is fully expanded depicting some members projecting radially outwardly. 
       FIG. 14  is an enlarged, partial perspective view of one U-shaped member with its tip projecting outwardly after expansion. 
   

   DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     FIG. 1  illustrates a stent  10  incorporating features of the invention which is mounted onto a delivery catheter  11 . The stent generally comprises a plurality of radially expandable cylindrical elements  12  disposed generally coaxially and interconnected by elements  13  disposed between adjacent cylindrical elements. The delivery catheter  11  has an expandable portion or balloon  14  for expanding of the stent  10  within an artery  15 . The artery  15 , as shown in  FIG. 1  has a dissected lining  16  which has occluded a portion of the arterial passageway. 
   The delivery catheter  11  onto which the stent  10  is mounted, is essentially the same as a conventional balloon dilatation catheter for angioplasty procedures. The balloon  14  may be formed of suitable materials such as polyethylene, polyethylene terephthalate, polyvinyl chloride, nylon and ionomers such as Surlyn® manufactured by the Polymer Products Division of the Du Pont Company. Other polymers may also be used. In order for the stent  10  to remain in place on the balloon  14  during delivery to the site of the damage within the artery  15 , the stent  10  is compressed onto the balloon. A retractable protective delivery sleeve  20  as described in co-pending applications Ser. No. 07/647,464 filed on Apr. 25, 1990 and entitled STENT DELIVERY SYSTEM may be provided to further ensure that the stent stays in place on the expandable portion of the delivery catheter  11  and prevent abrasion of the body lumen by the open surface of the stent  20  during delivery to the desired arterial location. Other means for securing the stent  10  onto the balloon  14  may also be used, such as providing collars or ridges on the ends of the working portion, i.e. the cylindrical portion, of the balloon. 
   Each radially expandable cylindrical element  12  of the stent  10  may be independently expanded. Therefore, the balloon  14  may be provided with an inflated shape other than cylindrical, e.g. tapered, to facilitate implantation of the stent  10  in a variety of body lumen shapes. 
   In a preferred embodiment, the delivery of the stent  10  is accomplished in the following manner. The stent  10  is first mounted onto the inflatable balloon  14  on the distal extremity of the delivery catheter  11 . The balloon  14  is slightly inflated to secure the stent  10  onto the exterior of the balloon. The catheter-stent assembly is introduced within the patient&#39;s vasculature in a conventional Seldinger technique through a guiding catheter (not shown). A guidewire  18  is disposed across the damaged arterial section with the detached or dissected lining  16  and then the catheter-stent assembly is advanced over a guidewire  18  within the artery  15  until the stent  10  is directly under the detached lining  16 . The balloon  14  of the catheter is expanded, expanding the stent  10  against the artery  15 , which is illustrated in FIG.  2 . While not shown in the drawing, the artery  15  is preferably expanded slightly by the expansion of the stent  10  to seat or otherwise fix the stent  10  to prevent movement. In some circumstances during the treatment of stenotic portions of an artery, the artery may have to be expanded considerably in order to facilitate passage of blood or other fluid therethrough. 
   The stent  10  serves to hold open the artery  15  after the catheter  11  is withdrawn, as illustrated by FIG.  3 . Due to the formation of the stent  10  from elongated tubular member, the undulating component of the cylindrical elements of the stent  10  is relatively flat in transverse cross-section, so that when the stent is expanded, the cylindrical elements are pressed into the wall of the artery  15  and as a result do not interfere with the blood flow through the artery  15 . The cylindrical elements  12  of stent  10  which are pressed into the wall of the artery  15  will eventually be covered with endothelial cell growth which further minimizes blood flow interference. The undulating portion of the cylindrical sections  12  provide good tacking characteristics to prevent stent movement within the artery. Furthermore, the closely spaced cylindrical elements  12  at regular intervals provide uniform support for the wall of the artery  15 , and consequently are well adapted to tack up and hold in place small flaps or dissections in the wall of the artery  15  as illustrated in  FIGS. 2 and 3 . 
     FIG. 4  is an enlarged perspective view of the stent  10  shown in  FIG. 1  with one end of the stent shown in an exploded view to illustrate in greater detail the placement of interconnecting elements  13  between adjacent radially expandable cylindrical elements  12 . Each pair of the interconnecting elements  13  on one side of a cylindrical element  12  are preferably placed to achieve maximum flexibility for a stent. In the embodiment shown in  FIG. 4  the stent  10  has three interconnecting elements  13  between adjacent radially expandable cylindrical elements  12  which are 120 degrees apart. Each pair of interconnecting elements  13  on one side of a cylindrical element  12  are offset radially 60 degrees from the pair on the other side of the cylindrical element. The alternation of the interconnecting elements results in a stent which is longitudinally flexible in essentially all directions. Various configurations for the placement of interconnecting elements are possible, and several examples are illustrated schematically in  FIGS. 7-10 . However, as previously mentioned, all of the interconnecting elements of an individual stent should be secured to either the peaks or valleys of the undulating structural elements in order to prevent shortening of the stent during the expansion thereof. 
     FIG. 10  illustrates a stent of the present invention wherein three interconnecting elements  12  are disposed between radially expandable cylindrical elements  11 . The interconnecting elements  12  are distributed radially around the circumference of the stent at a 120-degree spacing. Disposing four or more interconnecting elements  13  between adjacent cylindrical elements  12  will generally give rise to the same considerations discussed above for two and three interconnecting elements. 
   The properties of the stent  10  may also be varied by alteration of the undulating pattern of the cylindrical elements  13 .  FIG. 11  illustrates an alternative stent structure in which the cylindrical elements are in serpentine patterns but out of phase with adjacent cylindrical elements. The particular pattern and how many undulations per unit of length around the circumference of the cylindrical element  13 , or the amplitude of the undulations, are chosen to fill particular mechanical requirements for the stent such as radial stiffness. 
   The number of undulations may also be varied to accommodate placement of interconnecting elements  13 , e.g. at the peaks of the undulations or along the sides of the undulations as shown in  FIGS. 5 and 11 . 
   In keeping with the invention, and with reference to FIGS.  4  and  12 - 14 , cylindrical elements  12  are in the form of a serpentine pattern  30 . As previously mentioned, each cylindrical element  12  is connected by interconnecting elements  13 . Serpentine pattern  30  is made up of a plurality of U-shaped members  31 , W-shaped members  32 , and Y-shaped members  33 , each having a different radius so that expansion forces are more evenly distributed over the various members. 
   As depicted in  FIGS. 13 and 14 , after cylindrical elements  12  have been radially expanded, outwardly projecting edges  34  are formed. That is, during radial expansion U-shaped members  31  will tip outwardly thereby forming outwardly projecting edges. These outwardly projecting edges provide for a roughened outer wall surface of stent  10  and assist in implanting the stent in the vascular wall by embedding into the vascular wall. In other words, outwardly projecting edges embed into the vascular wall, for example artery  15 , as depicted in FIG.  3 . Depending upon the dimensions of stent  10  and the thickness of the various members making up the serpentine pattern  30 , any of the U-shaped members  31 , W-shaped members  32 , and Y-shaped members  33  can tip radially outwardly to form a projecting edge  34 . It is most likely and preferred that U-shaped members  31  tip outwardly since they do not join with any connecting member  13  to prevent them from expanding outwardly. 
   The stent  10  of the present invention can be made in many ways. However, the preferred method of making the stent is to coat a thin-walled tubular member, such as stainless steel tubing, with a material which is resistive to chemical etchants, remove portions of the coating to expose underlying tubing which is to be removed but to leave coated portions of the tubing in the desired pattern for the stent so that subsequent etching will remove the exposed portions of the metallic tubing, but will leave relatively untouched the portions of the metallic tubing which are to form the stent. The coated portion of the metallic tube is in the desired shape for the stent. An etching process avoids the necessity of removing burrs or slag inherent in conventional or laser machining process. It is preferred to remove the etchant-resistive material by means of a machine-controlled laser as illustrated schematically in FIG.  6 . 
   A coating is applied to a length of tubing which, when cured, is resistive to chemical etchants. “Blue Photoresist” made by the Shipley Company in San Jose, Calif., is an example of suitable commercially available photolithographic coatings. The coating is preferably applied by electrophoretic deposition. 
   To ensure that the surface finish is reasonably uniform, one of the electrodes used for the electrochemical polishing is a doughnut-shaped electrode which is placed about the central portion of the tubular member. 
   The tubing may be made of suitable biocompatible material such as stainless steel, titanium, tantalum, superelastic NiTi alloys and even high strength thermoplastic polymers. The stent diameter is very small, so the tubing from which it is made must necessarily also have a small diameter. Typically the stent has an outer diameter on the order of about 0.06 inch in the unexpanded condition, the same outer diameter of the tubing from which it is made, and can be expanded to an outer diameter of 0.1 inch or more. The wall thickness of the tubing is about 0.003 inch. In the instance when the stent was plastic, it would have to be heated within the arterial site where the stent is expanded to facilitate the expansion of the stent. Once expanded, it would then be cooled to retain its expanded state. The stent may be conveniently heated by heating the fluid within the balloon or the balloon directly by a suitable system such as disclosed in a co-pending application Ser. No. 07/521,337, filed Jan. 26, 1990 entitled DILATATION CATHETER ASSEMBLY WITH HEATED BALLOON which is incorporated herein in its entirety by reference. The stent may also be made of materials such as superelastic NiTi alloys such as described in co-pending application Ser. No. 07/629,381, filed Dec. 18, 1990, entitled SUPERELASTIC GUIDING MEMBER which is incorporated herein in its entirety by reference. In this case the stent would be formed full size but deformed (e.g. compressed) into a smaller diameter onto the balloon of the delivery catheter to facilitate transfer to a desired intraluminal site. The stress induced by the deformation transforms the stent from a martensite phase to an austenite phase and upon release of the force, when the stent reaches the desired intraluminal location, allows the stent to expand due to the transformation back to the martensite phase. 
   Referring to  FIG. 6 , the coated tubing  21  is put in a rotatable collet fixture  22  of a machine controlled apparatus  23  for positioning the tubing  21  relative to a laser  24 . According to machine-encoded instructions, the tubing  21  is rotated and moved longitudinally relative to the laser  24  which is also machine controlled. The laser selectively removes the etchant-resistive coating on the tubing by ablation and a pattern is formed such that the surface of the tube that is to be removed by a subsequent chemical etching process is exposed. The surface of the tube is therefore left coated in the discrete pattern of the finished stent. 
   A presently preferred system for removing the coating on the tubing includes the use an 80-watt CO 2  laser, such as a Coherent Model 44, in pulse mode (0.3 mS pulse length); 48 mA key current and 48 W key power with 0.75 W average power, at 100 Hz; Anorad FR=20; 12.5 Torr; with no assist gas. Low pressure air is directed through the fine focus head to ensure that no vapor contacts the lens. The assist gas jet assembly on the laser unit may be removed to allow a closer proximity of the fine focus head and the collet fixture. Optimum focus is set at the surface of the tubing. Cured photo-resist coating readily absorbs the energy of the CO 2  wavelength, so that it can be readily removed by the laser. A coated 4-inch length of 0.06 inch stainless steel tubing is preferred and four stents can be patterned on the length of tubing. Three tabs or webs between stents provide good handling characteristics for the tubing after the etching process. 
   The process of patterning the resistive coating on the stent is automated except for loading and unloading the length of tubing. Referring again to  FIG. 6  it may be done, for example, using a CNC-opposing collet fixture  22  for axial rotation of the length of tubing, in conjunction with a CNC X/Y table  25  to move the length of tubing axially relative to a machine-controlled laser as described. The entire space between collets can be patterned using the CO 2  laser set-up of the foregoing example. The program for control of the apparatus is dependent on the particular configuration used and the pattern to be ablated in the coating, but is otherwise conventional. 
   This process makes possible the application of present photolithography technology in manufacturing the stents. While there is presently no practical way to mask and expose a tubular photo-resist coated part of the small size required for making intravascular stents, the foregoing steps eliminate the need for conventional masking techniques. 
   After the coating is thus selectively ablated, the tubing is removed from the collet fixture  22 . Next, wax such at ThermoCote N-4 is heated to preferably just above its melting point, and inserted into the tubing under vacuum or pressure. After the wax has solidified upon cooling, it is reheated below its melting point to allow softening, and a smaller diameter stainless steel shaft is inserted into the softened wax to provide support. The tubing is then etched chemically in a conventional manner. After cutting the tabs connecting the stents any surface roughness or debris from the tabs is removed. The stents are preferably electrochemically polished in an acidic aqueous solution such as a solution of ELECTRO-GLO #300, sold by the ELECTRO-GLO CO., Inc. in Chicago, Ill., which is a mixture of sulfuric acid, carboxylic acids, phosphates, corrosion inhibitors and a biodegradable surface active agent. The bath temperature is maintained at about 110-135 degrees F. and the current density is about 0.4 to about 1.5 amps per in. 2  Cathode to anode area should be at least about two to one. The stents may be further treated if desired, for example by applying a biocompatible coating. 
   While the invention has been illustrated and described herein in terms of its use as an intravascular stent, it will be apparent to those skilled in the art that the stent can be used in other instances such as to expand prostatic urethras in cases of prostate hyperplasia. Other modifications and improvements may be made without departing from the scope of the invention. 
   Other modifications and improvements can be made to the invention without departing from the scope thereof.