Abstract:
A method and system for producing tomosynthesis images of a breast specimen in a cabinet x-ray system. An X-ray source delivers X-rays through a specimen of excised tissue and forms an image at a digital X-ray detector. Multiple X-ray images are taken as the X-ray source moves relative to the stationary breast specimen. In the preferred embodiment, the X-ray source moves in a range from about 350° to and including about 10°. The source may travel substantially along a path that generally defines an arc, or linearly, while the detector remains stationary throughout and the source remains substantially equidistant from the specimen platform. The set of X-ray image data taken at the different points are combined to form a tomosynthesis image that can be viewed in different formats, alone or as an adjunct to conventional specimen radiography.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application claims priority to and the benefit of U.S. Provisional Patent Application Ser. No. 61/902,878, filed on 12 Nov. 2013, the disclosure of which is incorporated herein by reference in its entirety. 
     
    
     BACKGROUND 
       [0002]    1. Field of the Present Disclosure 
         [0003]    The aspects of the disclosed embodiments are directed to the field of cabinet X-ray imaging of excised human tissue, and more specifically, to a system and method for obtaining and processing cabinet X-ray image data for tomosynthesis reconstruction allowing for a three-dimensional image of the specimen. 
         [0004]    2. Description of the Related Art 
         [0005]    Imaging of a patient&#39;s tissue has become a common screening tool and/or diagnostic aid in modern medicine. Breast cancer remains a significant threat to women&#39;s health and is considered the most common cancer among women today. One strategy for dealing with breast cancer is early detection of the cancer so that it may be treated prior to the cancer metastasizing throughout the body. This causes an increase in the number of surgical procedures performed involving excision of cancerous tissue or calcifications, such as ductal carcinoma in situ (DCIS). 
         [0006]    The excision of DCIS is a challenging task. In order to assure that the complete DCIS lump including a cancer-free margin has been excised, the following steps may be undertaken. A pre-operational planning based on mammograms is performed carefully in order to assess the size and the location of the lump. The location of the lump is marked utilizing guide wires/markers. During the lumpectomy, the excised tissue is examined using X-ray imaging in order to assess whether its margin is cancer-free. If it is found that the excised specimen has an insufficient margin of cancer-free tissue, the surgeon removes more tissue. 
         [0007]    Currently, X-ray images obtained are only available in two-dimensional mode, and as such, orthogonal views of the sample must be obtained by physically rotating the specimen to verify the margins. The breast surgeon relies on the radiogram to verify removal of the complete lump. If necessary, the breast surgeon may have to identify additional breast tissue that must be excised to ensure a clear margin. This is an error prone and time consuming task that is performed under significant time pressure whilst the anesthetized patient is still lying on the operating table. 
         [0008]    In typical X-ray imaging, a patient&#39;s breast sample is immobilized and contained in a specimen container. The sample is placed between an X-ray source and a digital imaging device (detector) to create a two-dimensional radiographic image of the sample. To ensure that margins are attained, at least 2 orthogonal images must be taken of the sample (90 degrees apart). The problem that arises with the above scenario is that the tissue, being somewhat fluid, may displace when it is imaged in either position, which may cause and provide a false measurement to the breast surgeon. It would be advantageous to be able to image the sample from a greater number of different positions of the source and receptor relative to the sample while maintaining the sample stationary or in a fixed position. 
         [0009]    Digital tomosynthesis combines digital image capture and processing with simple tube/detector motion as used in conventional radiographic tomography. Although there are some similarities to CT, it is a separate technique. In CT, the source/detector makes a complete 360-degree rotation about the subject obtaining a complete set of data from which images may be reconstructed. In digital tomosynthesis, a small change of flux created by only a small rotation angle with a small number of exposures are used. This set of data can be digitally processed to yield images similar to conventional tomography with a limited depth of field. However, because the image processing is digital, a series of slices at different depths and with different thicknesses can be reconstructed from the same acquisition, saving time. 
         [0010]    Image data taken at the different imaging positions can be processed to generate tomosynthetic images of selected slices of the sample. The images can be of thin slices, essentially planar sections through the specimen, as in CT slices. Alternatively, they can be varying thickness. 
         [0011]    The isocenter of the image acquisition geometry is located below the sample, on the surface of the detector. The phase shifts created as a result of this arrangement are compensated for, while processing the resultant dataset. The tomosynthetic images are then generated from the generated data set. 
         [0012]    It is believed that no cabinet specimen tomosynthesis systems are commercially available currently for clinical use in specimen imaging, and that improvements in X-ray imaging and tomosynthesis are a desired goal. Accordingly, it is believed that there is a need for improved and practical tomosynthesis of breast specimens. 
         [0013]    It would be advantageous to have a cabinet X-ray system for specimen imaging that could create, via digital tomosynthesis, a three-dimensional image for the breast surgeon to ensure that a proper margin around the diseased tissue has been excised in an expedient manner. 
       SUMMARY 
       [0014]    As described herein, the exemplary embodiments overcome one or more of the above or other disadvantages known in the art. 
         [0015]    In one embodiment, the aspects of the present disclosure are directed to a method and system for obtaining breast specimen x-ray images, projection tomosynthesis x-ray images, and reconstructed tomosynthesis x-ray images of a patient&#39;s breast specimen (also referred to herein as a “sample”) and or performing digital tomosynthesis on an object. In one embodiment, the method and system includes an x-ray source, a flat panel digital x-ray detector, a specimen platform or container and a motion control mechanism configured for moving the source relative to the specimen (collectively referred to herein as the “unit”). The x-ray source is selectively energized to emit x-rays through the sample to the detector at selected positions of the source relative to the sample. The detector is controlled to collect projection x-ray images of the sample when the source is energized at the selected positions. One of the projection images is a two-dimensional image taken at standard imaging angle of 0°, and a tomosynthetic image reconstructed from a collection of tomosynthesis projection images is created. 
         [0016]    In accordance with the aspects of the disclosed embodiments, the x-ray source moves around the stationary sample, typically, but not necessarily, in an arc. While the detector may rotate, in accordance with one aspect of the present disclosure, the detector remains stationary to maintain an equidistant center point. The x-ray data taken at each of a number of positions of the source relative to the sample is processed to form images, where two or more of the differing imaging positions are utilized to form a digital tomosynthesis image. 
         [0017]    The collection of the tomosynthesis projection images is processed, typically using a computing device or other processor, into one or more reconstructed images representing a volume of the sample and relating to one or more image planes that are selectively the same or different from that of the 2-D image. The 2-D image and the reconstructed tomosynthesis images are selectively displayed. 
         [0018]    The above allows the clinician verification via a display of either a three-dimensional or slice/multiplanar view of the sample that margins have been attained by the surgeon. 
         [0019]    In a further aspect, the disclosed embodiments are directed to method and system for selectively using the same x-ray equipment to take, process and display a 2-D specimen radiography image and projection tomosynthesis images. In one embodiment, this includes an x-ray source, a flat panel digital x-ray detector, and a specimen platform or container and a motion control mechanism configured for moving the source relative to the specimen (collectively referred to herein as the “unit”). The x-ray source is selectively energized to emit x-rays through the sample or specimen to the detector at selected positions of the source relative to the sample. The detector is controlled to collect projections x-ray images of the sample when the source is energized at the selected positions. One of the projection images is a two-dimensional image taken at standard imaging angle of 0°. A tomosynthetic image reconstructed from a collection of projection images is created. 
         [0020]    The above aspects of the disclosed embodiments overcome the deficiencies of the prior art by advantageously allowing the operator to be able to view the sample in a three-dimensional mode and take varying slices to ensure that the surgeon has attained a correct margin in an expedient manner without having to manipulate the excised sample. 
         [0021]    In one aspect, the present disclosure is directed to a cabinet X-ray system. In one embodiment, the system includes an X-ray source, a flat panel digital X-ray detector, a specimen platform and a motion control mechanism configured for moving the source relative to the specimen or sample (collectively referred to herein as the “imaging unit”). The components of the system described above are disposed or contained in a cabinet. 
         [0022]    In one embodiment, the X-ray source is selectively energized to emit X-rays through the sample to the detector at selected positions of the source relative to the sample. In one embodiment, a control unit or X-ray controller can be used to selective energize the X-ray source. 
         [0023]    The detector is controlled to collect projection X-ray images of the sample when the source is energized at the selected positions. Preferably, one of the projection images is a two-dimensional image taken at a standard imaging angle of 0°. A tomosynthetic image reconstructed from a collection of tomosynthesis projection images is created. 
         [0024]    The collection of the tomosynthesis projection images is processed, typically using a computing device or other processor, into one or more reconstructed images. The reconstructed images represent a volume of the sample and relate to one or more image planes that are selectively the same or different from that of the 2-D image. The 2-D image and the reconstructed tomosynthesis images are selectively displayed. 
         [0025]    This allows the clinician verification via a display of either a three-dimensional or slice/multiplanar view of the sample that margins have been attained by the surgeon. 
         [0026]    In a further aspect, the disclosed embodiments are directed to method and system for selectively using the same X-ray equipment to take, process and display a 2-D specimen radiography image and projection tomosynthesis images. In one embodiment, this includes an X-ray source, a flat panel digital X-ray detector, and a specimen platform or container and a motion control mechanism configured for moving the source relative to the specimen or sample (collectively referred to herein as the “unit”). The X-ray source is selectively energized to emit X-rays through the sample or specimen to the detector at selected positions of the source relative to the sample. The detector is controlled to collect projections X-ray images of the sample when the source is energized at the selected positions. One of the projection images is a two-dimensional image taken at standard imaging angle of 0° and a tomosynthetic image reconstructed from a collection of projection images is created. 
         [0027]    The collection of the tomosynthesis projections images is processed by a computer or other processor into one or more reconstructed images representing a volume of the sample and relate to one or more image planes that are selectively the same or different from that of the 2-D specimen image. The 2-D specimen image and the reconstructed tomosynthesis images are selectively displayed. 
         [0028]    The above aspects of the disclosed embodiments overcome the deficiencies of the prior art by advantageously allowing the operator to be able to view the sample in a three-dimensional mode and take varying slices to ensure that the surgeon has attained a correct margin in an expedient manner without having to manipulate the excised sample. 
         [0029]    In a further aspect, the present disclosure relates to a cabinet system for performing X-ray digital Tomosynthesis on an object. In one embodiment, the cabinet system includes an imaging unit with an X-ray source; a digital X-ray detector; and a specimen platform positioned adjacent the digital X-ray detector and adapted to support an object thereon. 
         [0030]    In one embodiment, the system includes a motion control mechanism to which the X-ray source is mounted is configured for moving the X-ray source along a path within the cabinet to selected positions relative to the object. 
         [0031]    In one embodiment, the system includes an X-ray control unit configured to selectively energize the X-ray source to emit X-rays toward the object. 
         [0032]    In one embodiment, the system includes a computer system coupled to and for controlling the digital X-ray detector, the motion control mechanism and X-ray control unit; wherein the computer system is configured to control the digital X-ray detector, the motion control mechanism and X-ray control unit and collect 2-D X-ray images of the object from the digital X-ray detector when the X-ray source is energized at the selected positions to create a collection of 2-D X-ray projection images. The computer system is further configured to process the collection of 2-D X-ray images into at least one reconstructed 3-D tomosynthesis image. A display or monitor is coupled to the computer to display the at least one reconstructed 3-D tomosynthesis image. 
         [0033]    In another aspect, the present disclosure is directed to a method of cabinet X-ray digital imaging. In one embodiment, the method includes an imaging unit comprising an X-ray source, a digital X-ray detector, a specimen platform positioned adjacent the digital X-ray detector and adapted to support an imaging object thereon, a motion control mechanism to which the X-ray source is mounted that is configured for moving the X-ray source along a path to selected positions relative to the imaging, means of selectively energizing the X-ray source to emit X-rays toward the imaging object in communication with the X-ray source, a computer system in communication with the digital X-ray detector, the motion control mechanism and means of selectively energizing the X-ray source; wherein the computer system is configured to control the digital X-ray detector, the motion control mechanism and means of selectively energizing the X-ray source and collect 2-D X-ray images of the imaging object from the digital X-ray detector when the X-ray source is energized at the selected positions to create a collection of 2-D X-ray projection images. 
         [0034]    In one embodiment, the computer system is configured to process the collection of 2-D X-ray images into at least one reconstructed 3-D tomosynthesis image including a volume of the imaging object or an image plane of the imaging object. The at least one reconstructed 3-D tomosynthesis image can be displayed. 
         [0035]    These and other aspects and advantages of the exemplary embodiments will become apparent from the following detailed description considered in conjunction with the accompanying drawings. It is to be understood, however, that the drawings are designed solely for purposes of illustration and not as a definition of the limits of the invention, for which reference should be made to the appended claims. Moreover, the drawings are not necessarily drawn to scale and that, unless otherwise indicated, they are merely intended to conceptually illustrate the structures and procedures described herein. In addition, any suitable size, shape or type of elements or materials could be used. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0036]    FIG.  1 —Schematically illustrates a front view of an X-ray source, a specimen/sample, and a digital detector, where the X-ray source moves relative to the specimen for imaging the specimen at different angles, in one embodiment of a system incorporating aspects of the present disclosure. 
           [0037]    FIG.  2 —Schematically illustrates an exemplary orientation of the X-ray source, specimen, and digital detector as viewed when the door of the cabinet is open, in one embodiment of a system incorporating aspects of the present disclosure. 
           [0038]    FIG.  3 —Displays an exemplary workflow/flowchart of an aspect of the disclosed embodiments. 
           [0039]    FIG.  4 —Displays an example of an X-ray Cabinet System incorporating aspects of the present disclosure. 
           [0040]    FIG.  5 —Displays the sample chamber of the embodiment of  FIG. 4  with the swing arm and a detector. 
           [0041]    FIG.  6 —Displays the lateral view of the X-ray source of the embodiment of  FIG. 4  mounted to the top of the swing arm. 
           [0042]      FIGS. 7A ,  7 B and  7 C—Displays the results of the imaging of an apple at multiple depth cuts after tomosynthesis reconstruction in a cabinet X-ray system incorporating aspects of the present disclosure. 
       
    
    
     DETAILED DESCRIPTION 
       [0043]    The systems and methods of the present disclosure address the needs of the art by providing tomosynthesis apparatus and techniques for imaging breast specimens that overcome the shortfall of the data received from two-dimensional imaging systems. The aspects of the present disclosure enable the use of tomosynthesis to efficiently provide accurate three-dimensional imaging of a specimen in which overlapping images having differing attenuation characteristics by applying a three-dimensional reconstruction algorithm, all in an X-ray cabinet. 
         [0044]    As used herein, the term “computer,” “computer system” or “processor” refers to any suitable device operable to accept input, process the input according to predefined rules, and produce output, including, for example, a server, workstation, personal computer, network computer, wireless telephone, personal digital assistant, one or more microprocessors within these or other devices, or any other suitable processing device with accessible memory. 
         [0045]    The term “computer program” or “software” refers to any non-transitory machine readable instructions, program or library of routines capable of executing on a computer or computer system including computer readable program code. 
         [0046]    Specimen Tomography is a three-dimensional specimen imaging system. It involves acquiring images of a sample at multiple viewpoints, typically over an arc or linear path. The three-dimensional (3-D) image is constructed by the reconstruction of the multiple image data set. 
         [0047]    One embodiment of a system  100  incorporating aspects of the present disclosure is illustrated in  FIG. 1  The system  100  is totally enclosed or housed in an X-ray cabinet  22 . In accordance with the aspects of the disclosed embodiments, the X-ray source  10  moves around the stationary sample  18 , typically, but not necessarily, in an arc. References  12 ,  14  and  16  of  FIG. 1  illustrate exemplary positions of the X-ray source  10  within the cabinet  22 . The reference “C” at each of the positions  12 ,  14 ,  16  of the source  10  in  FIG. 1  refers to the point source of the X-ray beam. The reference “M” refers to the spread or fan of the X-ray beam. 
         [0048]    While the detector  20  may move or rotate, in accordance with one aspect of the present disclosure, the detector  20  remains stationary relative to the sample  18  and source  10  to maintain an equidistant center point. The X-ray data taken at each of a number of exemplary positions  12 ,  14 ,  16  of the source  10  relative to the sample  18  within the cabinet  22  is processed to form images, where two or more of the differing imaging positions are utilized to form a digital tomosynthesis image. 
         [0049]    In one embodiment, the aspects of the present disclosure limit the arc or linear travel of the X-ray source  10  over about a 20° to about a 50° arc, preferably about 30°, more preferably about 20°. The movement can be clockwise or counter clockwise along a path, which includes for example, one or more, or a combination thereof, of the following exemplary ranges: between approximately 350° (reference position  12 ), to 0° (reference position  14 ) to 10° (reference position  16 ), or between approximately 340° (reference position  12 ) to 0° (reference position  14 ) to 20° (reference position  16 ) and or between approximately 335° (reference position  12 ) to 0° (reference position  14 ) to 25° (reference position  16 ). The ranges recited herein are intended to be approximate and inclusive of start and endpoints. In the example of  FIG. 1  the detector  20  is stationary as is the sample  18 . The sample  18 , also referred to as the “object” or “imaging object” is disposed on or rests on the protective cover  19  or other surface of the detector  20 . 
         [0050]    In operation, source  10  is energized to emit an X-ray beam, generally throughout its travel along one or more of the paths or positions described above. The X-ray beam travels through the sample  18  to the detector  20  and the multiple images collected at varying angles are stored and then utilized for the tomosynthesis reconstruction. The X-ray source  10  may range from about 0 kVp to about 90 kVp, preferably a 50 kVp 1000 μa X-ray source. 
         [0051]    Different embodiments of the present disclosure can utilize different ranges of motion of one or more of the source  10  and detector  20  as well as changing the angularity of one or both. The inventive aspects of the present disclosure differ from the prior art in that in prior art systems either the detector and source move and/or the isocenter is above the sample and not at the detector surface. In accordance with the aspects of the present disclosure, in one embodiment, the source  10  is configured to move, as is described herein, while the detector  20  is configured to remain stationary or in a fixed position. 
         [0052]    The detector  20  and associated electronics generate image data in digital form for each pixel at each of the angular positions  12 ,  14 ,  16  of source  10  and translation positions of the detector  20  relative to the sample  18 . While only three positions  12 ,  14 ,  16  are illustrated in  FIG. 1 , in practice more images are taken at differing angles. For example, in one embodiment, images can be taken at approximately every 1° of rotation or motion of source  10 . 
         [0053]      FIG. 2  schematically illustrates one embodiment of the orientation of the source  10  as seen when the door  24  is opened and the source  10  is locate at approximately 0°, reference point  14  in this example, within the cabinet  22 . In this embodiment, the motion of the source  10  can generally occur from the back to the front of the cabinet  22  with the detector  20  orientated, or otherwise disposed, at the base  26  of the cabinet  22 , within the cabinet chamber  28 . In one embodiment, the detector  20  is suitably coupled to the base  26  of the cabinet  22 . The X-ray spread in this example can be from about 0 kVp to about 50 kVp with the system preferably utilizing an AEC (Automatic Exposure Control) to ascertain the optimal setting to image the object or sample  18  being examined. 
         [0054]    In one embodiment, the detector  20 , X-ray source  10 , and the swing arm  50  ( FIG. 5 ) servo mechanism are controlled via a combination of one or more of software and hardware, such as non-transitory machine readable instructions stored in a memory that are executable by one or more processors. On example of such a configuration can include controller cards of a computer  470  ( FIG. 4 ), such as a MS Windows based computer. In one embodiment, non-transitory machine readable instructions being executed by one or more processors of the computer  470  is utilized to compile data received from the detector  20  and present resulting images to a suitable display or monitor  472  ( FIG. 4).t  each imaging position, such as positions  12 ,  14  and  16  shown in  FIG. 1 , the detector  20  generates the respective digital values for the pixels in a two-dimensional array. The size of detector  20  may range, for example, from about 2 inches by 2 inches to about 16 inches by 16 inches, preferably about 5 inches by 6 inches. In one example, detector  20  has a rectangular array of approximately 1536×1944 pixels with a pixel size of 74.8 micrometers. The image dataset attained at each respective position may be processed either at the full spatial resolution of detector  20  or at a lower spatial resolution by overlapping or binning a specified number of pixels in a single combined pixel value. 
         [0055]    For example, if we bin at a 2×2 ratio, then there would be an effective spatial resolution of approximately 149.6 micrometers. This binning may be achieved within the original programming of the detector  20  or within the computer  470  providing the tomosynthetic compilation and image. 
         [0056]      FIG. 3  illustrates one embodiment of an exemplary workflow from initiating  302  the system  100  through imaging, reconstruction and display  324  of data images collected of the sample  18 . 
         [0057]    As will be generally understood, the system  100  is initiated  302 , the cabinet door  24  opened  304 , and the sample  18  placed into  306  the chamber  28 . As shown in  FIG. 2 , for example, the sample  18  is positioned on the detector  20  in a suitable manner. The door  24  is closed  308 . 
         [0058]    The data and information regarding the subject, including any other suitable information or settings relevant to the imaging process and procedure, is entered  310  into the computer  470 . The scan is initiated  312 . The system  100  will take  314  scout or 2-D images at Top Dead Center, which for purposes of this example is location  14  of  FIGS. 1 and 2 . The source  10  can then be moved to other locations, such as locations  12  and  16 , and the detector  20  can be used to capture  316  images at various increments along the travel path of the source  10 , such as about every 1 degree. 
         [0059]    The captured images are stored  318  and digital tomosynthesis is performed  320 . The tomosynthesis image is then displayed  324 . 
         [0060]      FIG. 4  shows one embodiment of an X-ray Cabinet System  400  incorporating aspects of the present disclosure. In this embodiment, the X-ray Cabinet System  400  is mounted on wheels  458  to allow easy portability. In alternate embodiments, the cabinet system can be mounted on any suitable base or transport mechanism. The cabinet  422  in this example, similar to the exemplary cabinet  22  of  FIG. 1 , is constructed of a suitable material such as steel. In one embodiment, the cabinet  422  comprises painted steel defining a walled enclosure with an opening or cabinet chamber  428 . Within the cabinet chamber  428 , behind door  424 , resides an interior space forming a sample chamber  444 , which in this example is constructed of stainless steel. Access to the sample chamber  444  is via an opening  446 . In one embodiment, the opening  446  of the sample chamber  444  has a suitable door or cover, such as a moveable cover  448 . In one embodiment, the moveable cover  448  comprises a door which has a window of leaded glass. 
         [0061]    Between the outer wall  421  of cabinet  422  and the sample chamber  444  are sheets of lead  452  that serve as shielding to reduce radiation leakage emitted from the X-ray source  10 . In the example of  FIG. 4 , the X-ray source  10  is located in the upper part  456  of the cabinet  422 , in the source enclosure  468 . The detector  20  is housed in the detector enclosure  460  at an approximate midpoint  462  of the cabinet  422 . 
         [0062]    In one embodiment, a controller or computer  470  controls the collection of data from the detector  20 , controls the swing arm  60  shown in  FIGS. 5 &amp; 6 , and X-ray source  10 . A monitor  472  displays the compiled data and can, for example, be mounted on an articulating arm  474  that is attached to the cabinet  422 . The computer  470  receives commands and other input information entered by the operator via a user interface  476 , such as a keyboard and mouse for example. In one embodiment, the computer  470  can comprise a touch screen or near touch screen device. Although the aspects of the disclosed embodiments will generally be described with respect to a computer, it will be understood that the computer  470  can comprise any suitable controller or computing device. Such computing devices can include, but are not limited to, laptop computers, mini computers, tablets and pad devices. 
         [0063]    The computer  470  can be configured to communicate with the components of the system  400  in any suitable manner, including hardwired and wireless communication. In one embodiment, the computer  470  can be configured to communicate over a network, such as a Local Area Network or the Internet. 
         [0064]      FIG. 5  shows a front interior view and  FIG. 6  shows a lateral interior view of the sample chamber of imaging unit cabinet of  FIG. 4 . In this embodiment, a sample  18  is placed or otherwise disposed onto the detector  20 . Using the computer system  470  shown in  FIG. 4 , the operator enters in the parameters for the scan via the user interface  476 , which can be displayed on the monitor  472 . As used herein, the term “display” or “monitor” means any type of device adapted to display information, including without limitation CRTs, LCDs, TFTs, plasma displays, LEDs, and fluorescent devices. The computer system  470  then sends the appropriate commands to the X-ray source  10  and detector  20  to activate image collection while the swing arm  60  is moving along a path or arc from location  14  to  12  to  16  (which are shown in  FIGS. 1 and 5 ) or vice versa as described, which in this embodiment are at 345°, 0°, and 15° respectively with 0° at top dead center. At the end of the travel of the swing arm  60  at either position  12  or  16 , the computer  470  issues the command to the X-ray source  10  and the detector  20  to cease operating. The individual 2-dimensional (2-D) images which were collected, in this example at 1° increments, are then tabulated in the computer  470  to create the tomosynthetic images. In one embodiment, the operator may select which images they wish via the user interface  476  as they are being displayed on the monitor  472 . In one embodiment, the devices and components of the cabinet system  400  are suitably communicatively coupled together, including one or more of hard wire connections or wireless connections using a suitable wireless connection and communication transmission protocol, as will generally be understood. The system  400  can also be configured to transfer images via USB, CD-Rom, or WIFI. 
         [0065]    The dynamic imaging software of the disclosed embodiments reconstructs three-dimensional images (tomosynthesis) from two-dimensional projection images in real-time and on-demand. The software offers the ability to examine any slice depth, tilt the reconstruction plane for multiplanar views and gives higher resolution magnifications.  FIGS. 7A ,  7 B, and  7 C illustrate exemplary images of an apple using the above process. 
         [0066]      FIG. 7A  is an image of a slice of the apple at it&#39;s very top. 59 mm from the bottom.  FIG. 7B  is an image of an apple computed at 30.5 mm up from the detector, and  FIG. 7C  is a view of the apple computed at 13.5 mm from the bottom. 
         [0067]    The real-time image reconstruction of the present disclosure enables immediate review, higher throughput, and more efficient interventional procedures reducing patient call backs and data storage needs. Multiplanar reconstruction enables reconstruction to any depth, magnification and plane, giving the viewer the greater ability to view and interrogate image data, thereby reducing the likelihood of missing small structures. Built-in filters allow higher in-plane resolution and image quality during magnification for greater diagnostic confidence. Software is optimized for performance using GPU technology. 
         [0068]    The reconstruction software used in conjunction with the aspects of the present disclosure provides the users greater flexibility and improved visibility of the image data. It reconstructs images at any depth specified by the user, rather than at fixed slice increments. With fixed slice increments, an object located between two reconstructed slices, such as a calcification, is blurred and can be potentially missed. The aspects of the present disclosure provide for positioning the reconstruction plane so that any object is exactly in focus. This includes objects that are oriented at an angle to the detector  20 . The aspects of the present disclosure provide for the reconstruction plane to be angled with respect to the detector plane. 
         [0069]    Thus, while there have been shown and described and pointed out fundamental novel features of the invention as applied to the exemplary embodiments thereof, it will be understood that various omissions and substitutions and changes in the form and details of devices illustrated, and in their operation, may be made by those skilled in the art without departing from the spirit of the invention. For example, it is expressly intended that all combinations of those elements and/or method steps which perform substantially the same function in substantially the same way to achieve the same results are within the scope of the invention. Moreover, it should be recognized that structures and/or elements and/or method steps shown and/or described in connection with any disclosed form or embodiment of the invention may be incorporated in any other disclosed or described or suggested form or embodiment as a general matter of design choice. It is the intention, therefore, to be limited only as indicated by the scope of the claims appended hereto.