Abstract:
The present invention provides a microneedle patch container for effectively and hygienically securing a microneedle patch from manufacture to use. The container has a bottom surface recessed from the peripheral portion towards the centre, a side surface connected to the bottom surface and the peripheral portion, and a bottom-surface protruding portion protruding from the bottom surface. The flexible release-type sheet portion of the microneedle patch is secured to the protruding portion on the bottom surface. A lid can also be used which has a recessed portion pressing against the microneedle patch secured to the bottom-surface protruding portion of the container in the position corresponding to the bottom-surface protruding portion. This is preferably housed inside a pouch moulded from sterilised paper or sterilised film in order to keep the microneedle patch in an aseptic state.

Description:
TECHNICAL FIELD  
       [0001]    The present invention relates to a container containing microneedle patches. 
       BACKGROUND ART 
       [0002]    In order to impart modification effects and functional effects to a skin surface layer and a skin stratum corneum, liquid materials, ointments, cream preparations, tape preparations, patch preparations, poultice preparations, and the like containing medicinal ingredients have been conventionally used. Such preparations are intended to exhibit the effects by allowing the medicinal ingredients to penetrate into skin through their application or attachment to a skin surface. However, the above-mentioned conventional preparations cannot achieve sufficient effect, because simply applying the preparations to the skin brings about easy disappearance and loss of the medicinal ingredients due to a perspiration function of the skin, contact of the skin with the outside, and the like. Moreover, since the skin has a barrier function for preventing entry of foreign matters into a body, it is difficult to allow the medicinal ingredients to penetrate into the skin only through their application or attachment. 
         [0003]    Recently, as a method for solving these drawbacks and surely supplying the medicinal ingredients into the skin, microneedles have been developed, and research thereof has been conducted. The microneedles are microscopic needles with a length of less than 1 mm (Patent Document 1). When the microneedles are made of material which is easily dissolved to disappear in vivo, the inserted microneedles are dissolved in the skin and then absorbed to disappear (Patent Document 2). Therefore, if the medicinal ingredients are contained in the microneedles beforehand, the medicinal ingredients can be supplied to a particular place in the skin. A microneedle array is formed by arranging a number of such microneedles on a substrate, and it has been largely expected on practical uses because a delivery amount can be increased in proportion to the number of the needles (Patent Documents 2 to 4, Non-patent Document 1). A microneedle patch is an easily usable product formed by supplementing the microneedle array with an adhesive tape and the like for sticking the microneedle array on the skin. 
         [0004]    Because the microneedles have generally a length of shorter than 1 mm and a diameter of around 0.1 mm, they do not cause pain and bleeding at their insertion. An insert point closes quickly and does not leave any trace. As a result, the microneedles are recognized as an excellent method for delivering the particular medicinal ingredients to the particular point of the skin. The microneedles have attracted attention by having application as cosmetics, for example delivery of skin active components such as hyaluronic acid to the skin surface, concealment of lentigines and birthmarks, and the like, in addition to medical application such as delivery of vaccine. 
         [0005]    An early microneedle comprised around 100 microneedles on a solid substrate with an area of around 1 cm 2 . However, based on a recent increased demand for improving a wide part of a face at a time, a microneedle array comprising the microneedles on a softened substrate have been developed in order to fit the array to a non-planar face. 
         [0006]    Suitable containers are necessary for providing the microneedle arrays to consumers in the market. Since the microneedle array has a needle portion and it is necessary to protect the needle portion during transport, sale or preservation, containers for patches, such as tapes, which are widely used conventionally (Patent Documents 5 and 6), cannot be used as they are. In addition, containers for solid substrates (Patent Documents 7 to 9) cannot be used for the microneedle array with a soft substrate. 
       CITATION LIST 
     Patent Documents 
       [0000]    
       
         [Patent Document 1] JP 2002-517300 W 
         [Patent Document 2] JP 2003-238347 A 
         [Patent Document 3] JP 2006-346126 A 
         [Patent Document 4] JP 2008-284318 A 
         [Patent Document 5] JP 2006-056543 A 
         [Patent Document 6] JP 2008-518042 W 
         [Patent Document 7] Japanese Registered Utility Model No. 3152532 
         [Patent Document 8] JP 2010-75485 A 
         [Patent Document 9] JP 2010-75486 A 
       
     
       Non-Patent Document 
       [0000]    
       
         [Non-patent Document 1] Quan Ying-Shu, Kamiyama Fumio, The Course of Development and Manufacturing for Microneedle, Yakuzaigaku; The Academy of Pharmaceutical Science and Technology. Japan; H21-April 69(4), 272-276. 
       
     
       SUMMARY OF INVENTION  
     Technical Problem 
       [0017]    Since the microneedle patch is attached on skin to deliver the medicinal ingredients, it is necessary for the microneedle patch to be held hygienically so as not to lose its pharmacologic effect, during a period from its manufacture to use through a distribution process. For this purpose, the present invention aims to provide a microneedle patch container suitable for holding the microneedle patch in which an adhesive tape is supplemented to the microneedle array with the flexible substrate and a release sheet is attached on an adhesive surface of the tape. 
       Solution to Problem 
       [0018]    In order to solve the above-mentioned problem, a microneedle patch container according to the present invention comprises: one or plural bottom surfaces recessed from a peripheral portion; a side surface continuously connecting the bottom surfaces with the peripheral portion; and a bottom-surface protruding portion projecting from the bottom surfaces, characterized in that a release sheet portion of a flexible microneedle patch is held with the bottom-surface protruding portion. 
         [0019]    One microneedle patch container can contain the microneedle patches by the number of bottom surfaces. Generally, one microneedle patch container contains one microneedle patch. However, for example, in the case of the microneedle patch for being attached under an eye, since the microneedle patches are generally attached under right and left eyes, it is preferable in business to contain a set of two pieces. Moreover, two or more microneedle arrays may be held on one microneedle patch. In this case, two or more microneedle arrays can be contained in one container. 
         [0020]    Preferably, the microneedle patch container according to the present invention is structured to comprise a lid, the lid having recessed portions which press the microneedle patch held on the bottom-surface protruding portion in a position corresponding to a part of the bottom-surface protruding portion, and the lid not having recessed portions in a position corresponding to other part of the bottom-surface protruding portion. Although the release sheet portion of the microneedle patch is held on the bottom-surface protruding portion, when the recessed portions of the lid are configured to press the entire release sheet portion, the microneedle patch is closely contacted to the lid by the effect of static electricity. If the microneedle patch is attracted to the lid by the static electricity, the microneedle patch is popped up suddenly when the lid is removed, and the microneedle patch is attracted to the container and thus hardly taken out. The press by the recessed portions of the lid is preferably partial to weaken influence of the static electricity and facilitate handling of the container. To further reduce the influence of the static electricity and prevent the microneedle patch from being attracted to the lid, it is efficient and desirable that an area of the bottom-surface protruding portion is made larger than an area of the recessed portions of the lid. 
         [0021]    The bottom-surface protruding portion is preferably a nearly rectangular shape so as to easily press and hold the release sheet of the microneedles. Moreover, this rectangular shape may be divided into several parts so as to hold the four sides of the release sheet by a plurality of convex parts. 
         [0022]    The microneedle patch container may be desirably stacked by fitting the plurality of container each other. To do so, it is preferable that the outside of a bottom surface of the microneedle patch can partially press a microneedle patch contained in other microneedle patch container. Generally, in order to supply hyaluronic acid and the medicinal ingredients by attaching the microneedle patch to face and to achieve a beauty effect, such as wrinkle removing, it is necessary that the microneedle patch is attached while repeating its attachment for a few days. Therefore, it is desirable in business that the number of sheets which is necessary for a series of use can be packaged all together. 
         [0023]    It is preferable that a cut and a protrusion are provided in corresponding positions of the microneedle patch container and the lid to easily remove the lid from the container when the microneedle patch is used. This is because, although the microneedle patch container needs to be sealed from its manufacture until immediately before use, it needs to easily be taken out when the microneedle patch is used. 
         [0024]    In the bottom surface of the microneedle patch container, a swollen part for easily picking the microneedle patch is preferably provided. This is because, even when the microneedle patch closely contacted to the container by the static electricity, the microneedle patch is made easier to be picked. 
         [0025]    The surfaces of the microneedle patch container according to the present invention are preferably anti-static treated. This is because, when the container is charged electrostatically, the microneedle patch is attracted to the container and thus hardly taken out. 
         [0026]    Although this microneedle patch container can hold the microneedles in a closed state, it cannot necessarily hold them in an aseptic state. To hold the microneedles in the aseptic state, it is desirable that after the container and the microneedles have been aseptic processed, the container is stored and sealed in a pouch formed with sterilized paper or a sterilized film sheet. A plastic sheet and an aluminum sheet can be preferably used as the sterilized film sheet. Since the aluminum sheet has high sealability, it is especially preferable. 
         [0027]    In the case of a patch, that is, so-called an adhesive skin patch in which an active ingredient of an agent and an adhesive are mixed and spread on resin film, it is usual that a release sheet is put on the active ingredient, the release sheet is peeled off before attaching to skin, and the patch is attached to bring the active ingredient of the agent into contact with the skin directly. In this case, although the patch is desirably clean because it is attached on a stratum corneum of the skin, it is not required to be aseptic due to presence of barrier effect on the stratum corneum. 
         [0028]    In this respect, conditions necessary for the microneedle patch container are severer than requirements necessary for a patch container. Since the microneedles are inserted into the skin, they must be hygienically preserved. Moreover, if the needles are not sharp, they cannot be inserted into the skin, so that hard matter which may damage a needle tip cannot be used. In addition, since the needles are inserted into the skin, matter about which it is doubtful whether or not it is safe in vivo, such as an adhesive agent, must not be attached. Namely, the microneedles must be held and preserved with only the release sheet portion in a sterile state and a state in which the microneedles are not brought into contact with any part of the container. Therefore, the microneedle patch container is inevitably different in structure from the patch container, and it cannot be designed on the analogy of the patch container. 
         [0029]    In addition, when the microneedle array is flexible, a method for preserving a solid microneedle array cannot be used as it is. This is because holding methods are different between the solid microneedle array and the flexible microneedle array. 
         [0030]    Resin which is easy in injection molding processing or press processing is preferable, but material of the microneedle patch container is not particularly limited. The microneedle patch container is especially preferably transparent or translucent because a situation of contents can be seen from the outside. Moreover, it is desirable that penetrability to air and vapor is low and that the microneedle patch can be stably protected for a long term. For example, polyethylene terephthalate (PET), polypropylene (PP) and polyethylene (PE) are preferable, among which PET is especially preferable because deterioration and stinking caused by sterilisation with gamma ray or electron beam irradiation are slight. 
       Advantageous Effects of Invention 
       [0031]    According to the microneedle patch container of the present invention, the microneedle patch is held with the release sheet portion, and the microneedles portion does not contact with any part of the container. Even if the microneedle patch is a flexible sheet, it can be held hygienically until its unsealing. Using this container allows the microneedle patch to be easily taken out when needed. Furthermore, the containers may be stacked each other, and several microneedle patches which are necessary for a series of use may be simply packaged. 
         [0032]    The microneedle patch container of the present invention is designed to avoid influence of static electricity. This is because, if the influence of the static electricity exists, the microneedle patch is attracted to the lid and popped up suddenly when the lid is removed, and the microneedle patch is attracted to the container and thus hardly taken out. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0033]      FIG. 1  shows a microneedle patch used in Example 1 to 3. 
           [0034]      FIG. 2  shows the first example of the microneedle patch container. 
           [0035]      FIG. 3  shows a lid of the microneedle patch container of the first example. 
           [0036]      FIG. 4  shows the second example of the microneedle patch container. 
           [0037]      FIG. 5  shows a lid of the microneedle patch container of the second example. 
           [0038]      FIG. 6  shows the third example of the microneedle patch container. 
           [0039]      FIG. 7  shows the fourth example of the microneedle patch container. 
           [0040]      FIG. 8  also shows the fourth example of the microneedle patch container. 
           [0041]      FIG. 9  shows a microneedle array used in Example 5. 
           [0042]      FIG. 10  shows the fifth example of the microneedle patch container. 
       
    
    
     DESCRIPTION OF EMBODIMENTS 
       [0043]    Hereinafter, the embodiments of the present invention will be described in accordance with examples. Although the present examples were designed to contain microneedle patches which had been designed on the assumption of being attached under an eye, the present invention is not limited to the shape of the examples, and the design may be suitably changed according to microneedle array patches with other shapes. 
         [0044]      FIG. 1  shows a microneedle patch  10  used in the present examples. As shown in  FIG. 1 , a microneedle array  11  has a planar shape with a curved bottom of a semicylindrical cross section, a horizontal width of approximately 35 mm and a vertical width of approximately 15 mm. As an outline of the microneedle array  11  shown in  FIG. 1 , the semicylindrical cross section has a shape in which a convex curved part and another convex curved part, with a smaller curvature than the convex curved part, or another straight part are spaced from one another and in which ends of both parts are continued together. This shape is designed on the assumption of being attached under an eye. Microneedles of this microneedle array are provided on a flexible sheet to allow the entire microneedle array to change shape according to an unevenness of a face. The microneedle array comprises needles with a length of 30-1000 μm at the rate of 50-500 counts per cm 2 , but the size of the microneedle is not limited, Although the main component is hyaluronic acid, the microneedles contain components which are effective for wrinkle removing of skin and activation of skin rejuvenation. 
         [0045]    In about the same shape as the microneedle array portion, a large adhesive sheet  12  with a circumference of 2 to 10 mm is adhered to an opposite surface of the microneedle array surface. An adhesive surface is directed in the same direction as the array surface. Moreover, at the microneedle array surface side, a nearly rectangular release sheet  13  (70×45 mm) with the microneedle array portion removed is stuck to cover the adhesive surface. A bottom part of the adhesive sheet  12  is narrow to attach the microneedle array  11  as closely as possible to the eye. 
         [0046]    Because a cutting line is provided in the centre of the release sheet  13 , when the microneedle patch is used, an user has both ends of the release sheet and contacts the release sheet with an array-attached site (under the eye) expanding the form sheet to open, so that the microneedle patch is adhered by the adhesive sheet  12 . Then, by tapping the microneedle array  11  surface, the microneedles are inserted into skin keratin. Since it is said that a point of skin which is sensitive to pain is inside by around 1 mm from a skin surface, the user feels little pain caused by this insertion. 
       EXAMPLE 1 
       [0047]      FIG. 2  shows an example of a microneedle patch container suitable for the above-mentioned microneedle patch. It is made of polyethylene terephthalate (PET). A microneedle patch container  30  may be a container closed by covering with a lid.  FIG. 3  shows an example of a lid  20 . Surfaces of the microneedle patch container  30  and the lid  20  are anti-static treated. 
         [0048]    The microneedle patch container  30  of the present example is an almost rectangular shape with outer dimensions of approximately 88×63 mm and has an almost rectangular bottom surface  32  with a depth of approximately 5 mm and a size of approximately 72×49 mm which is recessed from a peripheral portion  31  in the centre. The bottom surface  32  is a plane with an almost uniform depth and is continued to the peripheral portion  31  via a side surface  33 . An almost oblong bottom-surface protruding portion  34  is provided from the bottom surface  32 . A height of the bottom-surface protruding portion  34  is approximately 2 mm and an upper part of the bottom-surface protruding portion is curved. Four side surface convex parts  35  are provided inside the side surface  33  and a height of the side surface convex parts is the same as the bottom convex part  34 . 
         [0049]    The container  30  has a size in which the microneedle patch  10  fits precisely. The microneedle patch  10  is precisely stored inside the container by directing the microneedles  11  surface downward. A zone  38  shown by double two-dot chain lines in  FIG. 2  shows a site at which the microneedles portion  11  exists when the microneedle patch  10  is contained in the container  30  and does not show structure of the container  30 . Then, the microneedle patch  10  is supported by the bottom-surface protruding portion  34  and the side surface convex parts  35 , and the microneedles portion  11  does not contact with any part of the container  30 . Upper right and lower left swollen parts of the recess of the container in the figure are provided to pick the microneedle patch easily in taking the microneedle patch out of the container. Although the microneedle patch fits precisely in the container, it can be picked easily by inserting fingers into the swelling parts. 
         [0050]    The lid  20  for the above-mentioned container is a rectangular shape with about the same size as the container  30 . The lid  20  has recessed portions  22  which are recessed from a peripheral portion  21  and matched with the recess  32  of the container  30 , When the container  30  is engaged with the lid  20 , the microneedle patch is caught and held by these recessed portions  22  and by the bottom-surface protruding portion  34  and the side surface convex parts  35  of the container. A protrusion  26  is located outside the lid  30 , and a cut  36  is located in a corresponding position outside the container  30 . They are provided to easily remove the lid from the container. 
         [0051]    In the microneedle patch container  30  of the present example, the microneedle patch is not completely pressed by the bottom-surface protruding portion  34  and the recessed portions  22  of the lid. If the microneedle patch is completely pressed, due to static electricity, the microneedle patch is attracted to the lid  20  and popped up suddenly when the lid is removed, and the microneedle patch is attracted to the container  30  and thus hardly taken out. 
         [0052]    As shown in  FIG. 2  and  FIG. 3 , the position of the bottom-surface protruding portion  34  of the container and the position of the recessed portions  22  of the lid shift from each other and are designed not completely to press the microneedle patch. In the present example, the recessed portions  22  of the lid are arranged towards a border of the bottom-surface protruding portion  34  from a top of the side surface convex parts  35 . Moreover, the recessed portions  22  of the lid are provided in upper and lower areas of the figure, while they are not provided in right and left areas. Accordingly, the microneedle patch is not pressed down in right and left parts of the bottom-surface protruding portion  34  in  FIG. 2 . Providing the parts in which the microneedle patch is not pressed down to avoid influence of the static electricity allows the microneedle patch to be easily taken out. 
         [0053]    It is possible that the microneedle patch container  30  of the present example is not covered with the lid and that other container is substituted for the lid to cover the microneedle patch container  30  from above with other container after the microneedle patches have been stored. Moreover, it is also possible that the microneedle patch container in which the microneedle patch has been stored is not covered with the lid and that it is contained, sealed and held in a pouch made of a sterile aluminum film sheet after aseptic process. Moreover, it is also possible that the microneedle patch container in which the microneedle patch has been stored is not covered with the lid, that it is instead covered with sterilized paper laminated with a heat-sealable film or polyethylene, and that the peripheral portion of the container and the film are fused by heat sealing to seal the microneedle patch container. 
       EXAMPLE 2 
       [0054]      FIG. 4  shows other example of the microneedle patch container. A microneedle patch container  50  may be a container closed by covering with a lid.  FIG. 5  shows an example of a lid  40 . The microneedle patch container  50  and the lid  40  are made of polyethylene terephthalate (PET) and their surfaces are anti-static treated. 
         [0055]    The microneedle patch container  50  of the present example is an almost rectangular shape with outer dimensions of approximately 88×63 mm and has an almost rectangular bottom surface  52  with a depth of approximately 5 mm and a size of approximately 72×49 mm which is recessed from a peripheral portion  51  in the centre. The bottom surface  52  is a plane with an almost uniform depth and is continued to the peripheral portion  51  via a side surface  53 . Twelve bottom-surface protruding portions  54  are provided from the bottom surface  52 . Five of these in upper and lower areas of the figure are almost collinear, respectively. Upper parts of the bottom-surface protruding portions  54  are curved, and all of the bottom-surface protruding portions have the same height of approximately 2.5 mm. 
         [0056]    Six side surface convex parts  55  are provided inside the side surface  53 , and the inside of the side surface convex parts have a size in which the microneedle patch  10  fits just precisely. When the microneedle patch is contained in this container, the release sheet  13  is precisely fit inside the six side surface projections  55  not to move in the longitudinal and cross directions, and the bottom-surface protruding portions  54  support the release sheet  13  without contacting with the microneedle array  11 . A zone  58  shown by double two-dot chain lines in  FIG. 4  shows a site at which the microneedles portion  11  exists when the microneedle patch  10  is contained in the container  30  and does not show structure of the container  50 . Then, the microneedle patch  10  is supported by the bottom-surface protruding portions  54  and the side surface convex parts  55 , and the microneedles portion  11  does not contact with any part of the container  50 . 
         [0057]    The lid  40  for the container of the present example is a rectangular shape with about the same size as the container  50 . The lid  40  has recessed portions  42  which are recessed from a peripheral portion  41  and matched with the recess of the container. When the container  50  is engaged with the lid  40 , the recessed portions  42  correspond to the bottom-surface protruding portions  54  of the container to hold the entire microneedle patch  10  from above and below. A protrusion  46  is located outside the lid  40 , and a cut  56  is located in a corresponding position outside the container  50 . They are provided to easily remove the lid from the container. 
         [0058]    Unlike the case of Example 1, in the microneedle patch container of the present example, a position where the microneedle patch container  50  and the lid  40  are closely contacted is only on the side surface projections. Accordingly, the microneedle patch is not strongly pressed but caught between the bottom-surface protruding portions of the container and the recessed portions of the lid with a little allowance. Moreover, the recessed portions of the lid are provided in upper and lower areas of the figure, while they are not provided in right and left areas. The microneedle patch is placed on the bottom-surface protruding portions in right and left areas of  FIG. 4 , where it is not sandwiched from above. 
       EXAMPLE 3 
       [0059]      FIG. 6  shows an example of a microneedle patch container which can contain two microneedle patches. A microneedle patch container  60  may be a container closed by covering with a lid. The microneedle patch container  60  is made of polyethylene terephthalate (PET) and its surface is anti-static treated. 
         [0060]    Although the microneedle patch container  60  has two bottom parts provided in a peripheral portion, configuration of each bottom part is similar to that of the container  50 , so that further detail is omitted. Moreover, it is considered that the lid of the container  60  can be easily estimated based on  FIG. 6  and the lid  40 , so that its illustration is omitted. The microneedle patches are held like the case of Example 2. 
       EXAMPLE 4 
       [0061]      FIG. 7  and  FIG. 8  show examples of a microneedle patch container in which a microneedle patch holding two microneedle arrays can be contained. In the microneedle patch, the two microneedle arrays  68  are held on one piece of release sheet paper. Moreover, in the case of the present example, adhesive tapes  69  are attached to only a part of the microneedle arrays. By this means, the two microneedle arrays can be easily contained than the case of  FIG. 6 . 
         [0062]      FIG. 7  shows the microneedle patch container  60  holding two elongate microneedle arrays. Outer dimensions are slightly bigger than the case of  FIG. 2 . A bottom surface  62  with a depth of approximately 5 mm recessed from a peripheral portion  61  is provided in the centre. An almost oblong bottom-surface protruding portion  64  is provided from the bottom surface. The bottom-surface protruding portion  64  may be formed relatively larger than the bottom-surface protruding portion  34  of  FIG. 2  to contain the two microneedle arrays. Moreover, a lateral bottom-surface protruding portion may be added between the two microneedle arrays of a central part. Configurations of other parts are similar to  FIG. 2 , so that their description is omitted. 
         [0063]    An example of the microneedle arrays  68  and an example of the adhesive tape  69  are shown by broken lines in  FIG. 7 . These broken lines are illustrations when the microneedle patch is contained in the container, and they do not show structure of the container. 
         [0064]      FIG. 8  shows the microneedle patch container  70  holding two thick microneedle arrays. Outer dimensions are slightly bigger than the case of  FIG. 4 . A nearly rectangular bottom surface  72  with a depth of approximately 5 mm recessed from a peripheral portion  71  is provided in the centre. The bottom surface  72  is a plane with an almost uniform depth and is continued to the peripheral portion  71  via a side surface. Twelve bottom-surface protruding portions  74  are provided from the bottom surface  72 . Five of these in upper and lower areas of the figure are almost collinear, respectively. Upper parts of the bottom-surface protruding portions  74  are curved, and all of the bottom-surface protruding portions have the same height of approximately 2.5 mm. Compared to  FIG. 4 , the bottom-surface protruding portion  74  of  FIG. 8  spreads relative to the entire container than the bottom-surface protruding portion  54  of  FIG. 4 , to hold the two microneedle arrays. This is because two microneedle arrays are held in a narrow space. 
         [0065]    An example of the microneedle arrays  68  and an example of the adhesive tape  69  are shown by broken lines in  FIG. 8 . These broken lines are illustrations when the microneedle patch is contained in the container, and they do not show structure of the container. 
       EXAMPLE 5 
       [0066]    An example for containing four microneedle arrays in one microneedle patch container is shown.  FIG. 9  shows a microneedle array with an adhesive sheet provided only in a peripheral portion of the microneedle array. The microneedle array comprises the adhesive sheet of course on a surface side where microneedles of the microneedle array are not provided, and it is convenient that the adhesive sheet does not exist on the backside of a part where the microneedles exist. Such a microneedle patch holding four microneedle arrays on one piece of release sheet is convenient when the four microneedle patches are used at a time. 
         [0067]    Although a microneedle patch container  80  of Example 5 may be the same shape as that of Example 4 as shown in  FIG. 10 , a container which is larger as a whole is easy to use for containing the four microneedle arrays. A bottom surface  82  with a depth of approximately 5 mm recessed from a peripheral portion  81  is provided in the centre. An almost oblong bottom-surface protruding portion  84  is provided from the bottom surface. It is convenient that the bottom-surface protruding portion  84  is formed relatively larger than the bottom-surface protruding portion  34  of  FIG. 2  to contain the four microneedle arrays. Moreover, a cross or columnar bottom-surface protruding portion may be added between the four microneedle arrays of a central part. Configurations of other parts are similar to  FIG. 2 , so that their description is omitted. 
         [0068]    The four microneedle arrays shown in  FIG. 9  are shown by broken lines in  FIG. 10 . These broken lines are illustrations when the microneedle patch is contained in the container, and they do not show structure of the container. 
       REFERENCE NUMERALS 
       [0000]    
       
           10  microneedle patch 
           11  microneedle array 
           12  adhesive sheet 
           13  release sheet 
           20 ,  40  lid for microneedle patch container 
           21 ,  41  peripheral portion of lid 
           22 ,  42  recess part of lid 
           26 ,  46  protrusion for to release fitting between lid and container 
           30 ,  50  microneedle patch container 
           31 ,  52 ,  61 ,  71 ,  81  peripheral portion of container 
           32 ,  52 ,  62 ,  72 ,  82  bottom surface recessed from peripheral portion of container 
           34 ,  54 ,  64 ,  74 ,  84  bottom surface convex part provided in recess of bottom surface 
           35 ,  55  side surface convex part 
           38 ,  58  zone 
           60 ,  70  microneedle patch container which can contain two microneedle arrays 
           68  microneedle array 
           69  adhesive tape 
           80  microneedle patch container which can contain four microneedle arrays 
           87  microneedle array 
           88  microneedle patch