Abstract:
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of a cardiovascular drug or a pharmaceutical acceptable salt thereof. The cardiovascular drug is selected from the group consisting of peripheral vasodilator reaming enhancer, angiotensin converting agent inhibitor, hypotension and shock therapeutic agent, diuretic, antiarrhythmic agent, antiarralciton drug, antihypertensive agent, anticoagulant thrombolytic agent, cardiac tonic, and intravenous (hemorrhoids) therapeutic agent. The cancer is selected from the group consisting of lung cancer, intestinal cancer, colorectal cancer, prostate cancer, liver cancer, bladder cancer, cervical cancer, breast cancer, and blood cancer.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This is a National Phase Application filed under 35 U.S.C. 371 as a national stage of PCT/CN2015/092768 filed Oct. 23, 2015, an application claiming the benefit under 35 USC 119(e) to the following U.S. Provisional Applications No. 62/068,298 filed Oct. 24, 2014, the content of each of which is hereby incorporated by reference in its entirety. 
     
    
     FIELD OF THE INVENTION 
       [0002]    The present invention provides new clinical indication of cardiovascular drugs, which were approved by FDA. Particularly, the present invention demonstrates that the cardiovascular drugs can effectively inhibit a variety of cancers. 
       BACKGROUND OF THE INVENTION 
       [0003]    Cancer is the most popular disease cause of death in the world. The cancer patients are gradually increase yearly, therefore the treatment method of the cancer has become an important issue. The medical treatments of cancer can be classified as surgical treatment, radiation therapy, chemotherapy and target therapy. 
         [0004]    Generally, the cancer drug, whether chemotherapy drug or target therapy drug, is inhibit the cancer cells&#39; duplication and split to prevent the tumor growth and metastasis. In clinical treatment options, the combination of chemotherapies and several targeted therapies were selected; try to eliminate cancer cells more effectively, by means of different mechanisms. Furthermore, if the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure. 
         [0005]    On the other side, treatment of cardiovascular disease aims to prevent or delay the progression of the disease. Also, it aims to reduce the risk of developing cardiovascular diseases. For example, some cardiovascular drugs can treat high blood pressure, and other cardiovascular drugs can promote blood flow in patients with heart failure. 
         [0006]    Based on the many years&#39; experience of inventors, the human cancer cells and normal cells often have different characteristics, the differences in patterns or mechanism variation might be seen as a foreign invader. The different cancel cells are located in different locations and the statuses of variations are related to the located environment. Thus, the inventors are the first person to propose the use of antibiotic drugs to inhibit the cancer cell growth. 
         [0007]    In contrast, these cardiovascular drugs have been used for decades and are recognized by FDA long time ago. These cardiovascular drugs already have been researched and analyzed to know the mechanism on human body. Therefore, the groundbreaking new application would be time-saving and cost effective if these drugs applied in treating cancer. Besides, the treatment effect would be improved if these drugs are used to combine with other treating method. 
         [0008]    Otherwise, the manufacturing of the drug is also a big problem. When the drug starting the clinical trials, there are lots of problems need to overcome, such as drug safety, patient selection, trial dose and other issues. Even the drug has approved by the FDA and sales on the market, there still possibly face the situation of the poor drug response in patients. Furthermore, if the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure. Therefore, the new drug development is very difficult. 
       SUMMARY OF THE INVENTION 
       [0009]    To solve the above problems, the present invention provides a usage of existing cardiovascular drugs, which have passed clinical trials. 
         [0010]    The experiment results showed that the cardiovascular drugs had no toxicity or only little toxicity to normal cells. However, there are more studies need to be test to know that whether the cardiovascular drugs have selection between normal cells and cancer cells. Besides, not all the cardiovascular drugs could inhibit the growth of cancer cells under same condition, there are still lots of problems need to be overcame. 
         [0011]    Term Definition 
         [0012]    The cardiovascular drugs can be classified to ten categories based on the features, includes: peripheral vasodilator reaming enhancer, angiotensin converting agent inhibitor, hypotension and shock therapeutic agent, diuretic, antiarrhythmic agent, antiarralciton drug, antihypertensive agent, anticoagulant and thrombolytic agent, cardiac tonic, intravenous (hemorrhoids) therapeutic agent. 
         [0013]    (1) Peripheral vasodilator reaming enhancer, which can directly or indirectly effect on peripheral blood vessels to increase blood flow, includes: Cilnidipine, Minoxidil, Prazosin HCl, Sildenafil citrate, Tadalafil (Cialis), Nicorandil (Ikorel), Lacidipine (Lacipil, Motens), Benidipine hydrochloride, Cilazapril monohydrate (Inhibace), Fosinopril sodium (Monopril), Almotriptan malate (Axert), Milrinone (Primacor), Avanafil, Lomerizine HCl, Histamine Phosphate, Chromocarb and Pinacidil. 
         [0014]    (2) Angiotensin converting agent inhibitor, which is used to inhibit ACE activity and reduce the production of vasopressin II, so as to reduce the bradykinin hydrolysis, lead to vasodilatation, blood volume, and decrease blood pressure, includes: Benazepril hydrochloride, Losartan potassium, Perindopril Erbumine (Aceon), Irbesartan (Avapro), Candesartan (Atacand), Olmesartan medoxomil (Benicar), Enalaprilat dehydrate, Telmisartan (Micardis), Ramipril (Altace), Valsartan (Diovan), Enalapril maleate (Vasotec), Candesartan cilexetil (Atacand), Conivaptan HCl (Vaprisol), Azilsartan Medoxomil (TAK-491) and Eprosartan Mesylate. 
         [0015]    (3) Hypotension and shock therapeutic agent, which includes: L-Adrenaline (Epinephrine), DL-Adrenaline and Methoxamine HCl. 
         [0016]    (4) Diuretic, which is used to increase the generation of urine and increase the excretion of human body water, includes: Bumetanide, Furosemide (Lasix), Metolazone(Zaroxolyn), Silodosin (Rapaflo), Chlorothiazide, Trichlormethiazide (Achletin), Torsemide (Demadex), Hydrochlorothiazide, Indapamide (Lozol), Dichlorphenamide (Diclofenamide), Amiloride hydrochloride dehydrate, Solifenacin succinate, Methyclothiazide, Benzthiazide, Meticrane, Bendroflumethiazide and Potassium Canrenoate. 
         [0017]    (5) Antiarrhythmic agent, which is used to inhibit abnormal heartbeat rhythm (arrhythmia), such as atrial fibrillation, atrial flutter, and ventricular tachycardia (ventricular tachycardia) and ventricular fibrillation, includes: Adenosine (Adenocard), Dofetilide (Tikosyn), Amiodarone HCl, Ibutilide fumarate, Propafenone (Rytmonorm) and Disopyramide Phosphate. 
         [0018]    (6) Antiarralciton drug, which is used to treat ischemic heart disease symptoms, includes Dexrazoxane Hydrochloride, Ranolazine dihydrochloride, Nisoldipine (Sular), Ranolazine (Ranexa), Acadesine, Nifedipine (Adalat), Amlodipine besylate (Norvasc), Diltiazem HCl (Tiazac), Ticagrelor and Oxprenolol HCl 
         [0019]    (7) Antihypertensive agent is a medicament for hypertension treatment, which is used to prevent high blood pressure complications, such as stroke and myocardial infarction, includes: Bisoprolol, Doxazosin mesylate, Alfuzosin hydrochloride (Uroxatral), Nebivolol (Bystolic), Reserpine, Methyldopa (Aldomet), Eplerenon, Nimodipine (Nimotop), Betaxolol hydrochloride (Betoptic), Carvedilol, Metoprolol tartrate, Felodipine (Plendil), Amlodipine (Norvasc), Phentolamine mesilate, Imidapril (Tanatril) HCl, Aliskiren hemifumarate, Sodium Nitroprusside, Propranolol HCl, Levobetaxolol HCl, Esmolol HCl, (R)-(+)-Atenolol, Guanethidine Sulfate and Lofexidine HCl. 
         [0020]    (8) Anticoagulant, thrombolytic agent is the flag used to prevent blood coagulation (coagulation). Those substances exist in leeches and blood-sucking insects. Anticoagulants can treat thrombotic diseases, include: Prasugrel (Effient), Cilostazol, Nafamostat mesylate, Clopidogrel (Plavix), Apixaban, Aminocaproic acid (Amicar), Dipyridamole (Persantine), Phenindione (Rectadione), Ticlopidine HCl, Ozagrel HCl, Argatroban, Bexarotene, Gabexate mesylate and Ozagrel and Anisindione. 
         [0021]    (9) Cardiac tonic includes: Pimobendan (Vetmedin), Ampiroxicam, Digoxigenin and Pindolol. 
         [0022]    (10) Intravenous (hemorrhoids) therapeutic agent includes: Edaravone (MCI-186), Daidzein, Ginkgolide A and Bisacodyl. 
         [0023]    In one of the embodiments, the cancer is selected from lung cancer, intestinal cancer, colorectal cancer, prostate cancer, liver cancer, bladder cancer, cervical cancer, breast cancer and blood cancer. 
         [0024]    In one of the embodiment of the present invention, wherein the effect concentration of the drug in the present invention is 20 mg/kg/day˜500 mg/kg/day. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0025]      FIG. 1  illustrates the analysis of cardiovascular drugs for cancer cells inhibition. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0026]    The present invention provides a usage of cardiovascular drugs for cancer inhibition pharmaceutical composition preparation, which feature is the pharmaceutical composition composed by an effective dosage of cardiovascular drug and a pharmaceutical acceptable salt. 
         [0027]    The cardiovascular drug of the present invention includes: Lenalidomide Valproic acid sodium salt (Sodium valproate), Decitabine, Bisoprolol, Dexrazoxane Hydrochloride, Prasugrel (Effient), Benazepril hydrochloride, Bumetanide, Cilnidipine, Cilostazol, Doxazosin mesylate, Edaravone (MCI-186), Losartan potassium, Minoxidil, Nafamostat mesylate, Bimatoprost, Alfuzosin hydrochloride (Uroxatral), Clopidogrel (Plavix), Prazosin HCl, Ranolazine dihydrochloride, Sildenafil citrate, Perindopril Erbumine (Aceon), Irbesartan (Avapro), Tadalafil (Cialis), Nebivolol (Bystolic), Pimobendan (Vetmedin), Candesartan (Atacand), Apixaban, Reserpine, Furosemide (Lasix), Olmesartan medoxomil (Benicar), Pyridostigmine Bromide (Mestinon), Metolazone (Zaroxolyn), Silodosin (Rapaflo), Chlorothiazide, Methyldopa (Aldomet), Adenosine (Adenocard), Ezetimibe (Zetia), Enalaprilat dehydrate, Dofetilide (Tikosyn), Trichlormethiazide (Achletin), Aminocaproic acid (Amicar), Busulfan (Myleran, Busulfex), Torsemide (Demadex), Eplerenone, Hydrochlorothiazide, Gemfibrozil (Lopid), Indapamide (Lozol), Telmisartan (Micardis), Nimodipine (Nimotop), Nisoldipine (Sular), Pitavastatin calcium (Livalo), Simvastatin (Zocor), Ramipril (Altace), Fenofibrate (Tricor, Trilipix), Ranolazine (Ranexa), Acadesine, Acipimox, Nifedipine (Adalat), Amlodipine besylate (Norvasc), Clofibrate (Atromid-S), Betaxolol hydrochloride (Betoptic), Carvedilol, Daidzein, toprolol tartrate, Diltiazem HCl (Tiazac), Tranexamic acid (Transamin), Felodipine (Plendil), Valsartan (Diovan), Dipyridamole (Persantine), Amlodipine (Norvasc), Fluvastatin sodium (Lescol), Phenindione (Rectadione), Enalapril maleate (Vasotec), Nicorandil (Ikorel), Amiodarone HCl, Ticlopidine HCl, Lacidipine (Lacipil, Motens), Suplatast tosylate, Benidipine hydrochloride, Ginkgolide A, Candesartan cilexetil (Atacand), Phentolamine mesilate, Nimesulide, Cytidine, Bromhexine HCl, Tiopronin (Thiola), Ozagrel HCl, Argatroban, Mitiglinide calcium, Rosiglitazone HCl, Atorvastatin calcium (Lipitor), Famotidine (Pepcid), Cleviprex (Clevidipine), Cilazapril monohydrate (Inhibace), Adiphenine HCl, Rivastigmine tartrate (Exelon), Detomidine HCl, Fosinopril sodium (Monopril), Almotriptan malate (Axert), Bexarotene, Gabexate mesylate, Rasagiline mesylate, Imidapril (Tanatril) HCl, Conivaptan HCl (Vaprisol), Ibutilide fumarate, Probucol, Arbidol HCl, S-(+)-Rolipram, Tebipenem pivoxil (L-084), Dichlorphenamide (Diclofenamide), Aliskiren hemifumarate, DL-Carnitine hydrochloride, D-Mannitol (Osmitrol), L-carnitine (Levocarnitine), Amantadine hydrochloride (Symmetrel), Clozapine (Clozaril), Milrinone (Primacor), Mitoxantrone Hydrochloride, Novobiocin sodium (Albamycin), Ozagrel, Pancuronium (Pavulon), Propafenone (Rytmonorm), Quinine hydrochloride dehydrate, Spectinomycin hydrochloride, Xylazine HCl, L-Adrenaline (Epinephrine), DL-Adrenaline, Trospium chloride (Sanctura), Amiloride hydrochloride dehydrate, Cloxacillin sodium (Cloxacap), Zidovudine (Retrovir), Thiamphenicol (Thiophenicol), Oseltamivir phosphate (Tamiflu), Lonidamine, Peramivir Trihydrate, Carfilzomib (PR-171), Pazopanib, Fosaprepitant dimeglumine, Otilonium Bromide, Solifenacin succinate, Besifloxacin HCl (Besivance), Azilsartan Medoxomil (TAK-491), Creatinine, Adrenalone HCl, Ampiroxicam, Desloratadine, Avanafil, Bisacodyl, Methyclothiazide, Sodium Nitroprusside, Vitamin D3 (Cholecalciferol), Deferiprone, Propranolol HCl, Mefenamic acid, Ticagrelor, sulfacetamide sodium, Lomerizine HCl, Levobetaxolol HCl, Dexlansoprazole, Esmolol HCl, Eprosartan Mesylate, Histamine Phosphate, Sevelamer HCl, Deoxyarbutin, Clorprenaline HCL, Ethamsylate, Chromocarb, Mevastatin, Mexiletine HCl, Phenazopyridine HCl, (R)-(+)-Atenolol, Anisindione, Benzthiazide, Disopyramide Phosphate, Guanethidine Sulfate, Isoetharine Mesylate, Methoxamine HCl, Meticrane, Oxprenolol HCl, Pinacidil, Bendroflumethiazide, Potassium Canrenoate, Digoxigenin, Lofexidine HCl and Pindolol. 
         [0028]    Cell Culture 
         [0029]    Subculture the different types of cancer cells. The cancer cells includes lung cancer, gastric cancer, hepatic cancer, colon cancer, skin cancer, cervical cancer, prostate cancer, bladder cancer, breast cancer, leukemia, pancreatic cancer, ovarian cancer, tongue cancer, osteosarcoma, and renal cancer. Cancer cell lines were cultured in different culture medium according to different characteristics (as shown in Table 1). The cell numbers were counted and reseed as 2×10 6  in cell culture plate/flask. Then, the culture medium for culturing the cell lines was added to a volume of 10 ml, and the cells were cultured for 2-3 days. Then, the cells were suspended for loading into 96-well plates. The cell number was 3000 cells and the volume of the culture medium was 100 ul each well. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Cancer cell lines and the culture medium 
               
             
          
           
               
                 tumor 
                 Cell line 
                 Culture medium 
               
               
                   
               
               
                 Lung cancer 
                 H1650 (Lung Adenocarcinoma) 
                 RPMI 
               
               
                   
                 A549 (Lung Adenocarcinoma) 
                 DMEM 
               
               
                 Stomach cancer 
                 AGS (Gastric Adenocarcinoma) 
                 RPMI 
               
               
                   
                 MKN-45 (Gastric Adenocarcinoma) 
                 RPMI 
               
               
                 Liver cancer 
                 HepG2 (Hepatocellular Carcinoma) 
                 DMEM 
               
               
                 Intestinal 
                 HCT116 (Colorectal Carcinoma) 
                 DMEM 
               
               
                 cancer 
                 LoVo (Colorectal Adenocarcinoma) 
                 DMEM 
               
               
                 Skin cancer 
                 A375 (Amelanotic Melanoma) 
                 DMEM 
               
               
                 Cervical cancer 
                 HeLa (Cervix Adenocarcinoma) 
                 DMEM 
               
               
                 Pr o state cancer 
                 PC3 (Prostate Adenocarcinoma) 
                 DMEM 
               
               
                 Bladder cancer 
                 TSGH-8301 (Urinary Bladder Carcinoma) 
                 RPMI 
               
               
                 Breast cancer 
                 MCF7 (Mammary Gland, Adenocarcinoma) 
                 DMEM 
               
               
                 Leukemia 
                 HL-60 (Acute Promyelocytic Leukemia) 
                 RPMI 
               
               
                   
               
             
          
         
       
     
         [0030]    Cell Viability Analysis 
         [0031]    Removing the original culture medium from 96-well plate. Then add 100 μl of commercially drug at a concentration of 10 μM per well. After 72 hours, add the diluted WST-1 reagent to the well with 100 μl/well, and the diluted WST-1 reagent was acquired from the dilution of 9:1 medium and WST-1 stock reagent. Finally, the total volume of each well are 200 μl/well. Culture the 96-well plate at 37° C. for 30 to 90 minutes. Detecting and calculating the survival rate of each cancer cells with an ELISA reader at OD450 nm. The lower viability of cancer cells represents better inhibition effect via the drugs. Otherwise, the higher viability of cancer cells represents worse inhibition effect via the drugs. 
         [0032]    Growth Inhibitory Effects on Cancer Cell Lines by Various Cardiovascular Drugs in the Present Invention 
         [0033]    For cell viability analysis, the cardiovascular drugs include peripheral vasodilator reaming enhancer, angiotensin converting agent inhibitor, hypotension and shock therapeutic agent, diuretic, antiarrhythmic agent, antiarralciton drug, antihypertensive agent, anticoagulant thrombolytic agent, cardiac tonic, intravenous (hemorrhoids) therapeutic agent, are used to test the inhibition effect of cancer cell. 
         [0034]    The test result showed that lots of cardiovascular drugs had no effect on cancer cell lines growth inhibition (Table 2). 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 The cardiovascular drugs which do not have  
               
               
                 significant inhibitory effect to cancer cells 
               
             
          
           
               
                   
                   
                 Numbers of inhibitory  
               
               
                   
                 cardiovascular drugs 
                 effect on cancer cell line 
               
               
                   
                   
               
             
          
           
               
                   
                 Bisoprolol 
                 0 
               
               
                   
                 Benazepril hydrochloride 
                 0 
               
               
                   
                 Bumetanide 
                 0 
               
               
                   
                 Furosemide (Lasix) 
                 0 
               
               
                   
                 Trichlormethiazide (Achletin) 
                 0 
               
               
                   
                 Aminocaproic acid (Amicar) 
                 0 
               
               
                   
                 Indapamide (Lozol) 
                 0 
               
               
                   
                 Simvastatin (Zocor) 
                 0 
               
               
                   
                 Ramipril (Altace) 
                 0 
               
               
                   
                 Fenofibrate (Tricor, Trilipix) 
                 0 
               
               
                   
                 Acadesine 
                 0 
               
               
                   
                 Acipimox 
                 0 
               
               
                   
                 Ticlopidine HCl 
                 0 
               
               
                   
                 Adiphenine HCl 
                 0 
               
               
                   
                 Rivastigmine tartrate (Exelon) 
                 0 
               
               
                   
                 Detomidine HCl 
                 0 
               
               
                   
                 Gabexate mesylate 
                 0 
               
               
                   
                 Rasagiline mesylate 
                 0 
               
               
                   
                 S-(+)-Rolipram 
                 0 
               
               
                   
                 Tebipenem pivoxil (L-084) 
                 0 
               
               
                   
                 Aliskiren hemifumarate 
                 0 
               
               
                   
                 Milrinone (Primacor) 
                 0 
               
               
                   
                 Novobiocin sodium 
                 0 
               
               
                   
                 Ozagrel 
                 0 
               
               
                   
                 Pancuronium (Pavulon) 
                 0 
               
               
                   
                 Propafenone (Rytmonorm) 
                 0 
               
               
                   
                 Xylazine HCl 
                 0 
               
               
                   
                 L-Adrenaline (Epinephrine) 
                 0 
               
               
                   
                 Lonidamine 
                 0 
               
               
                   
                 Bisacodyl 
                 0 
               
               
                   
                 Sodium Nitroprusside 
                 0 
               
               
                   
                 Mefenamic acid 
                 0 
               
               
                   
                 Ticagrelor 
                 0 
               
               
                   
                 sulfacetamide sodium 
                 0 
               
               
                   
                 Levobetaxolol HCl 
                 0 
               
               
                   
                 Dexlansoprazole 
                 0 
               
               
                   
                 Chromocarb 
                 0 
               
               
                   
                 Guanethidine Sulfate 
                 0 
               
               
                   
                 Isoetharine Mesylate 
                 0 
               
               
                   
                   
               
             
          
         
       
     
         [0035]    Besides, the inhibition effects of different cardiovascular drugs on different cancer cells were different (shown as  FIG. 1 ). According to the experiment, the Lenalidomide, Valproic acid sodium salt (Sodium valproate), Decitabine, Bisoprolol, Dexrazoxane Hydrochloride, Prasugrel (Effient), Benazepril hydrochloride, Bumetanide, Cilnidipine, Cilostazol, Doxazosin mesylate, Edaravone (MCI-186), Losartan potassium, Minoxidil, Nafamostat mesylate, Bimatoprost, Alfuzosin hydrochloride (Uroxatral), Clopidogrel (Plavix), Prazosin HCl, Ranolazine dihydrochloride, Sildenafil citrate, Perindopril Erbumine (Aceon), Irbesartan (Avapro), Tadalafil (Cialis), Nebivolol (Bystolic), Pimobendan (Vetmedin), Candesartan (Atacand), Apixaban, Reserpine, Furosemide (Lasix), Olmesartan medoxomil (Benicar), Pyridostigmine Bromide (Mestinon), Metolazone (Zaroxolyn), Silodosin (Rapaflo), Chlorothiazide, Methyldopa (Aldomet), Adenosine (Adenocard), Ezetimibe (Zetia), Enalaprilat dehydrate, Dofetilide (Tikosyn), Trichlormethiazide (Achletin), Aminocaproic acid (Amicar), Busulfan (Myleran, Busulfex), Torsemide (Demadex), Eplerenone, Hydrochlorothiazide, Gemfibrozil (Lopid), Indapamide (Lozol), Telmisartan (Micardis), Nimodipine (Nimotop), Nisoldipine (Sular), Pitavastatin calcium (Livalo), Simvastatin (Zocor), Ramipril (Altace), Fenofibrate (Tricor, Trilipix), Ranolazine (Ranexa), Acadesine, Acipimox, Nifedipine (Adalat), Amlodipine besylate (Norvasc), Clofibrate (Atromid-S), Betaxolol hydrochloride (Betoptic), Carvedilol, Daidzein, toprolol tartrate, Diltiazem HCl (Tiazac), Tranexamic acid (Transamin), Felodipine (Plendil), Valsartan (Diovan), Dipyridamole (Persantine), Amlodipine (Norvasc), Fluvastatin sodium (Lescol), Phenindione (Rectadione), Enalapril maleate (Vasotec), Nicorandil (Ikorel), Amiodarone HCl, Ticlopidine HCl, Lacidipine (Lacipil, Motens), Suplatast tosylate, Benidipine hydrochloride, Ginkgolide A, Candesartan cilexetil (Atacand), Phentolamine mesilate, Nimesulide, Cytidine, Bromhexine HCl, Tiopronin (Thiola), Ozagrel HCl, Argatroban, Mitiglinide calcium, Rosiglitazone HCl, Atorvastatin calcium (Lipitor), Famotidine (Pepcid), Cleviprex (Clevidipine), Cilazapril monohydrate (Inhibace). Adiphenine HCl, Rivastigmine tartrate (Exelon), Detomidine HCl, Fosinopril sodium (Monopril), Almotriptan malate (Axert), Bexarotene, Gabexate mesylate, Rasagiline mesylate, Imidapril (Tanatril) HCl, Conivaptan HCl (Vaprisol), Ibutilide fumarate, Probucol, Arbidol HCl, S-(+)-Rolipram, Tebipenem pivoxil (L-084), Dichlorphenamide (Diclofenamide), Aliskiren hemifumarate, DL-Carnitine hydrochloride, D-Mannitol (Osmitrol), L-carnitine (Levocarnitine), Amantadine hydrochloride (Symmetrel), Clozapine (Clozaril), Milrinone (Primacor), Mitoxantrone Hydrochloride, Novobiocin sodium (Albamycin), Ozagrel, Pancuronium (Pavulon), Propafenone (Rytmonorm), Quinine hydrochloride dihydrate, Spectinomycin hydrochloride, Xylazine HCl, L-Adrenaline (Epinephrine), DL-Adrenaline, Trospium chloride (Sanctura), Amiloride hydrochloride dihydrate, Cloxacillin sodium (Cloxacap), Zidovudine (Retrovir), Thiamphenicol (Thiophenicol), Oseltamivir phosphate (Tamiflu), Lonidamine, Peramivir Trihydrate, Carfilzomib (PR-171), Pazopanib, Fosaprepitant dimeglumine, Otilonium Bromide, Solifenacin succinate, Besifloxacin HCl (Besivance), Azilsartan Medoxomil (TAK-491), Creatinine, Adrenalone HCl, Ampiroxicam, Desloratadine, Avanafil, Bisacodyl, Methyclothiazide, Sodium Nitroprusside, Vitamin D3 (Cholecalciferol), Deferiprone, Propranolol HCl, Mefenamic acid, Ticagrelor, sulfacetamide sodium, Lomerizine HCl, Levobetaxolol HCl, Dexlansoprazole, Esmolol HCl, Eprosartan Mesylate, Histamine Phosphate, Sevelamer HCl, Deoxyarbutin, Clorprenaline HCL, Ethamsylate, Chromocarb, Mevastatin, Mexiletine HCl, Phenazopyridine HCl, (R)-(+)-Atenolol, Anisindione, Benzthiazide, Disopyramide Phosphate, Guanethidine Sulfate, Isoetharine Mesylate, Methoxamine HCl, Meticrane, Oxprenolol HCl, Pinacidil, Bendroflumethiazide, Potassium Canrenoate, Digoxigenin, Lofexidine HCl and Pindolol showed significant inhibition effect on different cancer cell lines (shown as Table 3). 
         [0036]    Although the present invention has been described in terms of specific exemplary embodiments and examples, it will be appreciated that the embodiments disclosed herein are for illustrative purposes only, and various modifications might be made by those skilled in the art without departing from the spirit and scope of the invention as set forth in the following claims. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 The inhibitory effect of cardiovascular drugs on various cancer cell lines 
               
             
          
           
               
                 Item Name 
                 A375 
                 HCT116 (WT) 
                 HepG2 
                 HeLa 
                 AGS 
                 H1650 
                 MKN-45 
                 TSGH 
                 A549 
                 MCF7 
                 PC3 
                 LoVo 
                 HL-60 
               
               
                   
               
             
          
           
               
                 Bisoprolol 
                 117.4 
                 118.0 
                 107.5 
                 110.8 
                 80.3 
                 80.7 
                 79.7 
                 87.5 
                 123.9 
                 111.9 
                 95.2 
                 118.8 
                 85.7 
               
               
                 Benazepril 
                 104.0 
                 60.0 
                 93.0 
                 75.9 
                 76.7 
                 61.6 
                 103.3 
                 77.5 
                 81.8 
                 126.1 
                 80.7 
                 96.0 
                 93.6 
               
               
                 hydrochloride 
               
               
                 Bumetanide 
                 67.6 
                 66.8 
                 86.0 
                 79.5 
                 69.9 
                 105.2 
                 98.8 
                 92.6 
                 88.2 
                 116.3 
                 72.7 
                 98.6 
                 98.3 
               
               
                 Furosemide (Lasix) 
                 87.6 
                 92.6 
                 103.5 
                 98.2 
                 97.4 
                 80.6 
                 64.2 
                 76.5 
                 142.0 
                 104.8 
                 191.9 
                 112.2 
                 100.3 
               
               
                 Trichlormethiazide 
                 128.4 
                 111.5 
                 95.1 
                 85.7 
                 79.3 
                 76.7 
                 71.0 
                 95.6 
                 106.3 
                 64.2 
                 122.3 
                 107.3 
                 102.2 
               
               
                 (Achletin) 
               
               
                 Aminocaproic acid 
                 122.7 
                 114.2 
                 101.2 
                 90.4 
                 64.8 
                 65.4 
                 80.2 
                 71.4 
                 70.3 
                 69.2 
                 79.6 
                 91.2 
                 93.0 
               
               
                 (Amicar) 
               
               
                 Indapamide (Lozol) 
                 64.8 
                 80.0 
                 84.0 
                 67.9 
                 109.2 
                 86.7 
                 104.9 
                 85.0 
                 105.8 
                 65.5 
                 76.8 
                 92.7 
                 101.2 
               
               
                 Simvastatin (Zocor) 
                 114.5 
                 124.2 
                 113.3 
                 103.6 
                 85.6 
                 114.7 
                 79.4 
                 101.0 
                 126.3 
                 81.5 
                 91.8 
                 99.9 
                 69.0 
               
               
                 Ramipril (Altace) 
                 120.3 
                 108.3 
                 105.6 
                 84.3 
                 99.8 
                 135.0 
                 84.0 
                 114.2 
                 99.6 
                 82.4 
                 103.5 
                 81.9 
                 107.3 
               
               
                 Fenofibrate (Tricor, 
                 158.8 
                 98.9 
                 103.7 
                 98.3 
                 84.1 
                 122.0 
                 83.1 
                 103.2 
                 101.1 
                 78.1 
                 105.2 
                 74.6 
                 77.6 
               
               
                 Trilipix) 
               
               
                 Acadasine 
                 99.1 
                 88.7 
                 103.1 
                 88.4 
                 75.4 
                 100.9 
                 81.5 
                 99.7 
                 117.1 
                 84.7 
                 94.8 
                 80.9 
                 110.1 
               
               
                 Acipimox 
                 123.9 
                 79.4 
                 99.8 
                 87.6 
                 87.5 
                 89.6 
                 80.2 
                 99.8 
                 107.8 
                 75.8 
                 94.5 
                 77.4 
                 102.2 
               
               
                 Ticlopidine HCl 
                 86.5 
                 71.9 
                 97.4 
                 81.9 
                 77.2 
                 61.6 
                 72.7 
                 111.5 
                 84.9 
                 96.8 
                 69.9 
                 90.5 
                 101.8 
               
               
                 Adiphenine HCl 
                 87.6 
                 133.9 
                 95.5 
                 96.4 
                 109.0 
                 118.7 
                 95.7 
                 82.0 
                 86.8 
                 102.9 
                 102.2 
                 95.7 
                 105.0 
               
               
                 Rivastigmine tartrate 
                 76.1 
                 117.6 
                 93.7 
                 90.1 
                 63.6 
                 83.6 
                 93.8 
                 83.9 
                 65.9 
                 67.5 
                 85.4 
                 85.4 
                 103.2 
               
               
                 (Exelon) 
               
               
                 Detomidine HCl 
                 84.8 
                 133.0 
                 102.3 
                 88.8 
                 68.5 
                 90.6 
                 91.0 
                 74.2 
                 81.1 
                 106.5 
                 89.2 
                 91.0 
                 104.8 
               
               
                 Gabexate mesylate 
                 77.9 
                 114.9 
                 92.0 
                 83.1 
                 75.0 
                 69.8 
                 81.1 
                 70.9 
                 77.3 
                 89.6 
                 94.2 
                 89.1 
                 117.6 
               
               
                 Rasagiline mesylate 
                 76.9 
                 141.9 
                 92.0 
                 88.1 
                 75.8 
                 71.8 
                 87.7 
                 74.2 
                 91.3 
                 88.3 
                 103.4 
                 94.0 
                 104.9 
               
               
                 S-(+)-Rolipram 
                 77.0 
                 86.2 
                 90.4 
                 69.0 
                 69.0 
                 73.1 
                 69.9 
                 81.1 
                 71.4 
                 80.4 
                 89.3 
                 94.1 
                 107.3 
               
               
                 Tebipenem pivoxil (L- 
                 60.4 
                 92.2 
                 73.8 
                 67.4 
                 63.7 
                 76.4 
                 77.4 
                 82.3 
                 73.5 
                 77.3 
                 90.1 
                 93.1 
                 101.6 
               
               
                 084) 
               
               
                 Aliskiren hemifumarate 
                 91.2 
                 97.2 
                 94.2 
                 107.8 
                 81.8 
                 79.8 
                 85.1 
                 73.3 
                 92.0 
                 99.1 
                 89.0 
                 99.5 
                 98.5 
               
               
                 Milrinone (Primacor) 
                 101.4 
                 104.1 
                 98.5 
                 99.0 
                 130.3 
                 86.2 
                 92.9 
                 101.1 
                 90.9 
                 98.5 
                 92.0 
                 90.5 
                 111.8 
               
               
                 Novobiocin sodium 
                 93.4 
                 115.9 
                 92.0 
                 96.1 
                 128.1 
                 93.5 
                 84.4 
                 85.3 
                 95.2 
                 109.2 
                 89.0 
                 87.1 
                 123.4 
               
               
                 (Albamycin) 
               
               
                 Ozagrel 
                 74.7 
                 102.5 
                 91.2 
                 77.7 
                 98.5 
                 80.6 
                 93.9 
                 69.4 
                 77.7 
                 101.8 
                 101.4 
                 80.6 
                 118.3 
               
               
                 Pancuronium (Pavulon) 
                 75.4 
                 101.8 
                 92.7 
                 83.3 
                 119.7 
                 91.7 
                 95.3 
                 68.3 
                 100.0 
                 110.3 
                 107.5 
                 79.8 
                 108.8 
               
               
                 Propafenone 
                 95.8 
                 109.2 
                 86.0 
                 108.8 
                 79.8 
                 92.5 
                 84.7 
                 61.1 
                 94.1 
                 119.7 
                 104.4 
                 105.3 
                 113.2 
               
               
                 (Rytmonorm) 
               
               
                 Xylazine HCl 
                 63.5 
                 100.6 
                 83.5 
                 65.1 
                 86.3 
                 67.2 
                 88.7 
                 61.5 
                 71.7 
                 104.4 
                 105.3 
                 96.6 
                 116.4 
               
               
                 L-Adrenaline 
                 101.9 
                 85.0 
                 81.6 
                 88.7 
                 61.1 
                 76.6 
                 69.4 
                 64.7 
                 90.8 
                 123.0 
                 106.0 
                 93.6 
                 101.8 
               
               
                 (Epinephrine) 
               
               
                 Lonidamine 
                 65.8 
                 81.2 
                 114.2 
                 61.6 
                 69.9 
                 65.9 
                 93.3 
                 86.4 
                 109.4 
                 86.9 
                 102.3 
                 96.1 
                 115.1 
               
               
                 Bisacodyl 
                 88.0 
                 122.0 
                 100.4 
                 89.2 
                 107.2 
                 93.6 
                 132.3 
                 104.3 
                 66.7 
                 65.0 
                 83.7 
                 85.5 
                 96.0 
               
               
                 Sodium Nitroprusside 
                 78.9 
                 125.6 
                 85.2 
                 107.4 
                 96.4 
                 109.4 
                 115.9 
                 106.8 
                 110.4 
                 97.2 
                 76.1 
                 70.9 
                 81.7 
               
               
                 Mefenamic acid 
                 78.7 
                 85.9 
                 100.7 
                 76.1 
                 71.1 
                 73.9 
                 114.8 
                 118.4 
                 116.5 
                 95.3 
                 102.8 
                 83.3 
                 113.4 
               
               
                 Ticagrelor 
                 60.1 
                 73.6 
                 94.5 
                 125.5 
                 100.5 
                 76.0 
                 114.5 
                 86.0 
                 85.0 
                 83.1 
                 84.1 
                 79.6 
                 93.7 
               
               
                 sulfacetamide sodium 
                 64.9 
                 76.7 
                 98.7 
                 75.9 
                 81.4 
                 79.8 
                 117.8 
                 120.3 
                 70.0 
                 110.2 
                 70.8 
                 81.8 
                 111.5 
               
               
                 Levobetaxolol HCl 
                 76.9 
                 70.3 
                 99.2 
                 88.7 
                 62.5 
                 69.9 
                 118.6 
                 98.2 
                 75.9 
                 85.0 
                 77.3 
                 80.0 
                 107.4 
               
               
                 Dexlansoprazole 
                 75.1 
                 82.8 
                 119.8 
                 104.7 
                 89.8 
                 69.6 
                 85.8 
                 84.9 
                 74.5 
                 72.1 
                 104.5 
                 102.0 
                 72.2 
               
               
                 Chromocarb 
                 63.4 
                 72.8 
                 95.6 
                 67.6 
                 81.8 
                 78.8 
                 100.3 
                 97.2 
                 61.1 
                 100.4 
                 88.3 
                 72.5 
                 110.1 
               
               
                 Guanethidine Sulfate 
                 81.1 
                 83.7 
                 85.5 
                 75.9 
                 86.3 
                 88.4 
                 116.7 
                 75.2 
                 101.4 
                 96.5 
                 100.8 
                 79.8 
                 106.7 
               
               
                 Isoetharine Mesylate 
                 97.0 
                 96.1 
                 76.5 
                 81.6 
                 96.6 
                 91.7 
                 91.0 
                 88.3 
                 76.7 
                 102.7 
                 71.6 
                 100.2 
               
               
                   
               
             
          
         
       
     
         [0037]    Repeated experiments for growth inhibitory effects on cancer cell lines by various cardiovascular drugs in the present invention 
         [0038]    According to the above mentioned cardiovascular drugs for cancer growth inhibition in Table 3, the inventors took the repeat experiments for the cardiovascular drugs to check the growth inhibitory effects of cancer cells by the cardiovascular drugs. The results were showed as Table. 4. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                 The inhibitory effect of cardiovascular drugs on various cancer cell lines 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 AGS 
                 MKN-45 
                 A549 
                 H1650 
                 TSGH-8301 
                 T24 
               
               
                   
               
               
                 Amlodipine besylate 
                 12.18342 
                 86.43411 
                 110.3104 
                 110.2477 
                 36.2492 
                 93.07934 
               
               
                 (Norvase) 
               
               
                 Nebivolol(Bystolic) 
                 26.60363 
                 52.82679 
                 48.95406 
                 87.37268 
                 38.02989 
                 97.6357 
               
               
                 Pimobendan 
                 60.81009 
                 65.23876 
                 58.25261 
                 77.77842 
                 59.42484 
                 74.23873 
               
               
                 (Vetmedin) 
               
               
                 Cilnidipine 
                 76.93947 
                 105.3923 
                 67.8263 
                 68.97714 
                 95.88997 
                 107.7523 
               
               
                 Losartan potassium 
                 74.09621 
                 82.7996 
                 96.04947 
                 77.1775 
                 91.97894 
                 66.27541 
               
               
                 Prazosin HCl 
                 86.83206 
                 70.11645 
                 72.20906 
                 100.6142 
                 99.83677 
                 88.51161 
               
               
                 Perindopril 
                 87.13689 
                 73.83094 
                 71.92761 
                 78.569 
                 105.3434 
                 87.89513 
               
               
                 Erbumine (Aceon) 
               
               
                 Nisoldipine (Sular) 
                 64.72004 
                 98.01894 
                 48.91949 
                 70.00318 
                 77.9189 
                 67.81543 
               
               
                 Amlodipine 
                 16.51631 
                 88.19584 
                 89.21803 
                 72.01455 
                 36.20415 
                 96.56012 
               
               
                 (Norvase) 
               
               
                 Benidipine 
                 87.82976 
                 92.86011 
                 70.30445 
                 64.52406 
                 81.48268 
                 60.98854 
               
               
                 hydrochloride 
               
               
                 Azelnidipine 
                 90.22252 
                 139.0039 
                 87.46658 
                 39.65028 
                 115.122 
                 79.46668 
               
               
                 Ouabain 
                 16.61027 
                 53.00617 
                 15.12608 
                 38.72274 
                 43.58029 
                 17.57783 
               
               
                 Disopyramide 
                 95.87973 
                 110.9738 
                 99.43989 
                 90.5041 
                 115.4261 
                 87.62175 
               
               
                 Phosphate 
               
               
                 Pitavastatin calcium 
                 19.17312 
                 61.30374 
                 89.44373 
                 49.9822 
                 48.91635 
                 52.63171 
               
               
                 (Livalo) 
               
               
                 Simvastatin (Zocor) 
                 80.96248 
                 92.58344 
                 109.6818 
                 79.82892 
                 105.9187 
                 89.62686 
               
               
                 Fluvastatin sodium 
                 51.95546 
                 65.29484 
                 98.76315 
                 73.07759 
                 78.17048 
                 71.79614 
               
               
                 (Lescol) 
               
               
                 Atorvastatin calcium 
                 31.48172 
                 84.18125 
                 90.1462 
                 69.54683 
                 70.58927 
                 78.47023 
               
               
                 (Lipitor) 
               
               
                   
               
               
                   
                 HepG2 
                 Hep3B 
                 HCT116 
                 LoVo 
                 HeLa 
                 C-33A 
               
               
                   
               
               
                 Amlodipine besylate 
                 95.00681 
                 123.4192 
                 78.25503 
                 85.56338 
                 101.287 
                 33.71715 
               
               
                 (Norvase) 
               
               
                 Nebivolol(Bystolic) 
                 42.12209 
                 44.81568 
                 81.90311 
                 85.28787 
                 52.00985 
                 76.97273 
               
               
                 Pimobendan 
                 87.23618 
                 94.82416 
                 53.63161 
                 66.73545 
                 34.00865 
                 62.77014 
               
               
                 (Vetmedin) 
               
               
                 Cilnidipine 
                 77.12693 
                 92.70906 
                 88.59966 
                 53.71666 
                 64.33688 
                 92.99393 
               
               
                 Losartan potassium 
                 93.9165 
                 102.6817 
                 105.8013 
                 106.1105 
                 83.41553 
                 108.1531 
               
               
                 Prazosin HCl 
                 87.24 
                 115.7343 
                 96.42385 
                 95.70664 
                 90.90437 
                 97.23898 
               
               
                 Perindopril 
                 99.43144 
                 99.52974 
                 64.99606 
                 83.48715 
                 66.66128 
                 90.91624 
               
               
                 Erbumine (Aceon) 
               
               
                 Nisoldipine (Sular) 
                 95.50526 
                 130.2372 
                 77.38842 
                 76.88917 
                 76.89186 
                 65.96391 
               
               
                 Amlodipine 
                 71.75803 
                 99.21563 
                 91.96059 
                 90.33212 
                 86.95599 
                 38.17616 
               
               
                 (Norvase) 
               
               
                 Benidipine 
                 83.57118 
                 98.76207 
                 90.62094 
                 69.00425 
                 92.92617 
                 105.186 
               
               
                 hydrochloride 
               
               
                 Azelnidipine 
                 100.8108 
                 98.58296 
                 111.283 
                 59.86935 
                 87.03299 
                 123.2929 
               
               
                 Ouabain 
                 38.05699 
                 33.35996 
                 15.8664 
                 39.68181 
                 23.12941 
                 35.48352 
               
               
                 Disopyramide 
                 108.9905 
                 113.0039 
                 93.97825 
                 104.5373 
                 102.7953 
                 98.46569 
               
               
                 Phosphate 
               
               
                 Pitavastatin calcium 
                 98.05696 
                 96.33898 
                 35.06809 
                 65.14687 
                 36.90614 
                 74.75168 
               
               
                 (Livalo) 
               
               
                 Simvastatin (Zocor) 
                 124.3915 
                 113.5223 
                 83.19968 
                 89.30886 
                 100.3977 
                 112.4884 
               
               
                 Fluvastatin sodium 
                 104.3733 
                 108.8002 
                 54.97113 
                 99.98781 
                 54.32329 
                 89.50117 
               
               
                 (Lescol) 
               
               
                 Atorvastatin calcium 
                 95.92241 
                 91.85783 
                 82.55431 
                 103.0307 
                 78.64343 
                 96.94654 
               
               
                 (Lipitor) 
               
               
                   
               
               
                   
                   
                   
                 MDA- 
                 NIH- 
               
               
                   
                 PC-3 
                 MCF-7 
                 MB231 
                 OVCAR-3 
                 TOV-21G 
                 AsPC-1 
               
               
                   
               
               
                 Amlodipine besylate 
                 73.55958 
                 80.48625 
                 82.71348 
                 91.55643 
                 93.54755 
                 87.83891 
               
               
                 (Norvase) 
               
               
                 Nebivolol(Bystolic) 
                 36.95159 
                 27.04214 
                 66.43548 
                 86.76822 
                 86.16763 
                 88.66097 
               
               
                 Pimobendan 
                 69.47215 
                 53.94911 
                 75.04087 
                 74.72196 
                 70.73536 
                 69.30304 
               
               
                 (Vetmedin) 
               
               
                 Cilnidipine 
                 61.39718 
                 64.63051 
                 86.26857 
                 75.85887 
                 62.8999 
                 57.59939 
               
               
                 Losartan potassium 
                 119.8879 
                 87.64286 
                 101.4346 
                 98.7328 
                 78.5729 
                 86.43686 
               
               
                 Prazosin HCl 
                 100.7353 
                 87.60617 
                 85.08244 
                 88.88644 
                 91.8658 
                 80.37522 
               
               
                 Perindopril 
                 81.06817 
                 75.64154 
                 63.78244 
                 79.59739 
                 71.22602 
                 64.22167 
               
               
                 Erbumine (Aceon) 
               
               
                 Nisoldipine (Sular) 
                 98.90966 
                 86.64786 
                 74.06174 
                 68.14248 
                 44.35767 
                 78.75132 
               
               
                 Amlodipine 
                 85.88287 
                 63.42196 
                 87.55328 
                 90.31382 
                 61.32005 
                 89.03664 
               
               
                 (Norvase) 
               
               
                 Benidipine 
                 88.48559 
                 77.28047 
                 77.34072 
                 85.24836 
                 47.45143 
                 63.35622 
               
               
                 hydrochloride 
               
               
                 Azelnidipine 
                 120.9111 
                 60.82186 
                 86.91866 
                 102.4284 
                 27.15468 
                 53.57238 
               
               
                 Ouabain 
                 25.76337 
                 29.14322 
                 44.49393 
                 42.33431 
                 15.89529 
                 20.08356 
               
               
                 Disopyramide 
                 103.4303 
                 107.038 
                 98.77022 
                 102.8007 
                 94.30529 
                 77.1867 
               
               
                 Phosphate 
               
               
                 Pitavastatin calcium 
                 27.53778 
                 83.56777 
                 39.0358 
                 61.40586 
                 21.78861 
                 51.36252 
               
               
                 (Livalo) 
               
               
                 Simvastatin (Zocor) 
                 92.77994 
                 88.80292 
                 71.08201 
                 98.38307 
                 63.61464 
                 78.20757 
               
               
                 Fluvastatin sodium 
                 32.11203 
                 82.4571 
                 43.03235 
                 84.73175 
                 50.48937 
                 83.55133 
               
               
                 (Lescol) 
               
               
                 Atorvastatin calcium 
                 56.4832 
                 79.08152 
                 47.83606 
                 98.29788 
                 34.04009 
                 81.09956 
               
               
                 (Lipitor) 
               
               
                   
               
               
                   
                 BxPC-3 
                 SAS 
                 U2OS 
                 A375 
                 BCC 
                 786-O 
               
               
                   
               
               
                 Amlodipine besylate 
                 99.10538 
                 94.7983 
                 71.05736 
                 136.6675 
                 102.9778 
                 73.16328 
               
               
                 (Norvase) 
               
               
                 Nebivolol(Bystolic) 
                 74.42236 
                 75.56914 
                 66.6423 
                 44.93539 
                 55.82216 
                 38.30332 
               
               
                 Pimobendan 
                 51.86991 
                 51.11398 
                 56.58073 
                 44.3967 
                 49.56082 
                 39.63967 
               
               
                 (Vetmedin) 
               
               
                 Cilnidipine 
                 68.6671 
                 38.91442 
                 43.14859 
                 47.06953 
                 60.17311 
                 86.69656 
               
               
                 Losartan potassium 
                 77.73778 
                 95.71052 
                 105.4483 
                 96.64672 
                 90.16032 
                 96.33382 
               
               
                 Prazosin HCl 
                 54.00243 
                 114.3263 
                 97.95575 
                 77.91429 
                 73.45319 
                 79.5367 
               
               
                 Perindopril 
                 49.97129 
                 52.47616 
                 73.98258 
                 83.20685 
                 58.70789 
                 86.19895 
               
               
                 Erbumine (Aceon) 
               
               
                 Nisoldipine (Sular) 
                 75.55234 
                 48.80258 
                 69.11154 
                 51.46547 
                 58.78716 
                 49.50878 
               
               
                 Amlodipine 
                 86.01719 
                 99.20403 
                 78.90455 
                 81.57538 
                 74.9299 
                 81.41545 
               
               
                 (Norvase) 
               
               
                 Benidipine 
                 73.78347 
                 64.48332 
                 54.15218 
                 76.01467 
                 74.60455 
                 78.8709 
               
               
                 hydrochloride 
               
               
                 Azelnidipine 
                 64.6017 
                 76.82412 
                 69.39511 
                 101.1726 
                 100.2223 
                 86.81704 
               
               
                 Ouabain 
                 27.01516 
                 20.23483 
                 22.80353 
                 18.38812 
                 25.61877 
                 14.51443 
               
               
                 Disopyramide 
                 69.94309 
                 96.93263 
                 98.72214 
                 113.872 
                 109.7018 
                 102.4512 
               
               
                 Phosphate 
               
               
                 Pitavastatin calcium 
                 59.77881 
                 38.0374 
                 43.44485 
                 22.09494 
                 26.77364 
                 16.46038 
               
               
                 (Livalo) 
               
               
                 Simvastatin (Zocor) 
                 81.82199 
                 83.91121 
                 65.60642 
                 78.63685 
                 57.35253 
                 87.7969 
               
               
                 Fluvastatin sodium 
                 79.10141 
                 81.50136 
                 91.20342 
                 21.78962 
                 27.03446 
                 23.64486 
               
               
                 (Lescol) 
               
               
                 Atorvastatin calcium 
                 81.02839 
                 76.29143 
                 86.25076 
                 23.01045 
                 41.49497 
                 32.53672 
               
               
                 (Lipitor)