Abstract:
The present disclosure relates to a macrolide compound as shown by formula I and pharmaceutically acceptable salt thereof. The compound of the present disclosure is an antibacterial agent, and can be used to treat various bacterial and protozoal infections. The presnt disclosure further relates to the preparation method of the compound and a pharmaceutical composition thereof.

Description:
TECHNICAL FIELD 
       [0001]    The present disclosure relates to the pharmaceutical field, and in particular to a novel 4″-substituted-9-deoxy-8A-aza-(8A-alkyl)-8A-homoerythromycin A derivative, an optical active isomer thereof, and a pharmaceutically acceptable salt thereof. The present disclosure also relates to a preparation method and a pharmaceutical composition comprising the derivative. The present disclosure further relates to use of the derivative in the treatment and/or prevention of diseases caused by various bacterial or protozoal infections. 
         [0002]    TECHNICAL BACKGROUND 
         [0003]    Macrolides, as an important category of anti-infection pharmaceuticals, have the advantages of excellent antibacterial activity, no anaphylactic reaction, minor side effect, and high safety. Through fifty years&#39; development, the macrolides have become the second largest category of anti-infection pharmaceuticals, ranking only next to β-lactam antibiotics in clinical application, and occupies an important position in clinical treatment. Erythromycin, which had been widely used in the treatment of infections caused by  Staphylococcus aureus, Streptococcus pneumonia, Streptococcus hemolyticus, Mycoplasma pneumonia,  and the like, is one of the first generation macrolide antibiotics and is especially applicable to patients allergic to penicillin. However, the application of erythromycin is limited due to its instability in acid medium. The second generation macrolide antibiotics represented by azithromycin can solve the above problem, and are greatly improved in terms of potency and pharmacokinetics. Azithromycin (9-deoxo-9A-methyl-9A-aza-homoerythromycin A) is the first 15-membered ring marolide antibiotic discovered by Bright (U.S. Pat. No. 4,474,768) and Kobrehe (U.S. Pat. No. 4,517,367), et al. Azithromycin is a special macrolide antibiotic obtained from erythromycin through oximation, Beckmann rearrangement reaction, and introduction of a nitrogen atom into the lactone ring thereof, and subsequently reduction and methylation. Azithromycin has outstanding features including a high stability in acidic media, a good tissue penetration, a long plasma half life, a wide range of clinical applicability, a significant efficacy, and less adverse effect. In particular, azithromycin has a wider antibacterial spectrum, and has so good antibacterial activity that can inhibit gram negative bacilli, such as  Haemophilus influenza,  making up the insufficiency of macrolide antibiotics in the inhibition of gram negative bacilli. 
         [0004]    Tulathromycin can be prepared by a process comprising firstly protecting the 2′-position of dihydro homoerythromycin, which is the starting material, then oxidizing and cyclizing the 4′-position thereof, removing the protecting group at the 2′-position, and subsequently aminating to form Tulathromycin in the form of salt. Tulathromycin is a newly launched macrolide semisynthetic antibiotic, which is specifically used on animals. Ministry of Agriculture of China issued a 957 th  announcement in 2008, first permitting the use of tulathromycin in animal production. Tulathromycin is mainly used in the treatment and prevention of swine and bovine respiratory diseases caused by  Actinobacillus, Mycoplasma, Pasteurella, Haemophilus parasuis,  and the like, and it has numerous advantages such as small dosage, single administration, low residue, and exclusive use on animals. 
         [0005]    However, due to the wide use of antibiotics, in particular the continuous and improper use, drug resistance against macrolide antibiotics extensively used at present, such as azithromycin and tulathromycin, has been developed, which brings extreme difficulties to clinical treatment. In addition, acute toxicity tests have proven that tulathromycin has relatively high oral toxicity. 
       SUMMARY OF THE INVENTION 
       [0006]    Given this, the present disclosure aims to provide a macrolide compound as shown by formula (I) and a pharmaceutically acceptable salt thereof. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0007]    wherein R′ is H H or C 1 -C 6  alkyl, 
         [0008]    R 1  is selected from a group consisting of H, hydroxyl, methoxyl, propargy, aryl, and a nitrogen-containing heterocyclic group, 
         [0009]    R 2  is hydroxyl, 
         [0010]    R 1  is —CH 2 R, wherein R is H or an organic group that contains or does not contain a heteroatom, the heteroatom being selected from a group consisting of O, N, S, and halogen, and 
         [0011]    R 4  is selected from a group consisting of H, acetyl, and carbobenzoxy. 
         [0012]    In the compound according to the present disclosure, preferably, R 3  is —CH 2 NR 20 R 30  or —CH 2 SR 40 , wherein each R 20 , R 30 , and R 40  is independently H or an organic group that contains or does not contain a heteroatom, the heteroatom being selected from a group consisting of O, N, S, and halogen, and R 20  and R 30  being optionally bonded to each other to form a ring. 
         [0013]    In the compound according to the present disclosure, preferably, R 3  is —CH 2 NHR 50 , and R 50  is an organic group that contains or does not contain a heteroatom, the heteroatom being selected from a group consisting of O, N, S, and halogen. More preferably, R 50  is selected from a group consisting of n-propyl, n-butyl, cyclopropyl, ethyl, isopropyl, isobutyl, tert-butyl, cyclopropylmethyl, 2-methoxyethyl, cyclopentyl, 2,4-difluorobenzyl, 3-methoxybenzyl, n-pentyl, 2-methyl-pyrazin-5-yl-methyl, 3-methoxypropyl, cyclohexylmethyl, and 4-methoxyphenethyl. 
         [0014]    According to the present disclosure, preferably, R 3  is —CH 2 NR 20 R 30 , and each R 20  and R 30  is independently selected from C 1 -C 6  alkyl. More preferably, each R 20  and R 30  is independently methyl or ethyl. 
         [0015]    In an embodiment according to the present disclosure, R in R 3  is a nitrogen-containing heterocyclic group, in which the nitrogen atom is directly attached to the carbon atom of methylene in R 3 . Preferably, R in R 3  is morpholinyl, piperidinyl, or piperazinyl. 
         [0016]    According to the present disclosure, preferably, R 20  and R 30  together form a 4 to 10-membered monocyclic ring, or a 5 to 10-membered heteroaryl ring optionally substituted by one or two alkyls. 
         [0017]    According to the present disclosure, preferably, one of R 20  and R 30  is H, and the other thereof is an organic group containing phenyl or benzyl. 
         [0018]    More preferably, the compound according to the present disclosure is a compound selected from a group consisting of: 
         [0019]    1) 
         [0020]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[propylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimeihylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0021]    2) 
         [0022]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C -methyl-3-O-methyl-4-C-[butylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-tiideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0023]    3) 
         [0024]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C -methyl-3-O-methyl-4-C-[(diethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0025]    4) 
         [0026]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(phenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0027]    5) 
         [0028]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(morpholinyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0029]    6) 
         [0030]    (2R3S,4R5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oso-7-azacyclopentadecan-15-one; 
         [0031]    7) 
         [0032]    (2R,3S,4R5S,8R10R, 11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(pyrryl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0033]    8) 
         [0034]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-fluorobenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0035]    9) 
         [0036]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(imidazolyl)methy]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacycopentadecan-15-one; 
         [0037]    10) 
         [0038]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(ethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacycopentadecan-15-one; 11) 
         [0039]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(isopropylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexorvranosyloxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0040]    12) 
         [0041]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(isobutylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0042]    13) 
         [0043]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[tert-butylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0044]    14) 
         [0045]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[piperidinylmethyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0046]    15) (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropylmethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0047]    16) 
         [0048]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-methoxybenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0049]    17) 
         [0050]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-chlorolbenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0051]    18) 
         [0052]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-pyridinylmethlamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0053]    19) 
         [0054]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-ethoxypropyl)amino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0055]    20) 
         [0056]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-methoxyethyl)amino-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0057]    21) 
         [0058]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[2-methoxybenzyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0059]    22) 
         [0060]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-[(N-methyl)amino]-ethyl)amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0061]    23) 
         [0062]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopentylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0063]    24) 
         [0064]    (2R,3S,4R,5S,8R10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl.-4-C-[2,4-difluorobenzyl-amino]methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0065]    25) 
         [0066]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(6-chloro-pyridazin-3-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0067]    26) 
         [0068]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(1-methyl-3-phenyl)propyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3.4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0069]    27) 
         [0070]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[3-methoxybenzyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0071]    28) 
         [0072]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[2,2,2-trifluoroacetyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0073]    29) 
         [0074]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[[(2-chloro-pyridin-4-yl-amino)-methyl]-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0075]    30) 
         [0076]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-]-O-methyl-4-C-[[[(4-formyl-benzyl-amino)-methyl]amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0077]    31) 
         [0078]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[propargyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0079]    32) 
         [0080]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[butyrate-2-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethy)amino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0081]    33) (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[butyrate-4-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0082]    34) 
         [0083]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-hydroxy-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0084]    35) 
         [0085]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[n-pentyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0086]    36) 
         [0087]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(morpholin-4-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0088]    37) 
         [0089]    3-({(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-6-[-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-1-oxa-7-azacyclopentadecan-15-one-13-yl-oxy]-3-hydroxy-4-methoxy-2,4-dimethyl-tetrahydropyran-3-yl-methyl-amino)-butyric acid; 
         [0090]    38) 
         [0091]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1-hydroxymethyl-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0092]    39) 
         [0093]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-hydroxy-2-phenyl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethy)amino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0094]    40) 
         [0095]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-dimethoxy-butylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0096]    41) 
         [0097]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,4-dichloro-benzylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0098]    42) 
         [0099]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1-methyl-4-dimethylaminobutylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0100]    43) 
         [0101]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(3-cyclohexylamino)propylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azaeyclopentadecan-15-one; 
         [0102]    44) 
         [0103]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(4-mesylphenylethylamino)propylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0104]    45) 
         [0105]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(1-methyl-but-1-en-3-yne-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0106]    46) 
         [0107]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(1-methyl-butyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0108]    47) 
         [0109]    (2R,3S,4R,5S,8R,10R,11R,12S,13R,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(2-pyridin-4-yl-ethylamine)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0110]    48) 
         [0111]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-]-O-methyl-4-C-{[(5-methyl-pyrazin-2-yl-methyl)-amino]-methyl}-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0112]    49) 
         [0113]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(3-methoxy-propyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxo-7-azacyclopentadecan-15-one; 
         [0114]    50) 
         [0115]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(cyclohexyl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxo-7-azacyclopentadecan-15-one; 
         [0116]    51) 
         [0117]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-fluoro-phenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0118]    52) 
         [0119]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-morpholinyl-propyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0120]    53) 
         [0121]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-furfuryl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0122]    54) 
         [0123]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-aminobenzyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0124]    55) 
         [0125]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(phenylhydrazono)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-↑-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0126]    56) 
         [0127]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-{[2-(1H-indol-3-yl)-ethylamino]-methyl}-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0128]    57) 
         [0129]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-chloropropyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0130]    58) 
         [0131]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,5-dimethoxyphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0132]    59) 
         [0133]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(thienylformyloxymethyl-2-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0134]    60) 
         [0135]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-methylfurfurylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0136]    61) 
         [0137]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-fluoro-phenylhydrazono)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0138]    62) 
         [0139]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(benzyloxy-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0140]    63) 
         [0141]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(6-dideoxy-3-C-methyl-3-O-methyl-4-C-](p-methoxyphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0142]    64) 
         [0143]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,4-dimethylphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0144]    65) 
         [0145]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-fluoropyridin-2-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0146]    66) 
         [0147]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-pyrrolyl-ethyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0148]    67) 
         [0149]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-pyridin-4-yl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0150]    68) 
         [0151]    (2R,3S,4R,5S,8R, 10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-fluorobenzyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0152]    69) 
         [0153]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-piperidin-4-yl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino -β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0154]    70) 
         [0155]    (2R,3S,4R,5S,8R,10R,11R, 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-chloro-o-methylphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one, 
         [0156]    71) 
         [0157]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-fluoro-phenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0158]    72) 
         [0159]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-fluoro-5-methylphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0160]    73) 
         [0161]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-methyl-4-chloro-phenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0162]    74) 
         [0163]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(N-methyl-butyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[3,4,6-trideoxy-3-(dimethy)amino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0164]    75) 
         [0165]    (2R,3S,4R5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(quinolin-6-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxo-7-azacyclopentadecan-15-one; 
         [0166]    76) 
         [0167]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1,2,2-trimethyl-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0168]    77) 
         [0169]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(n-propyl-amino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0170]    78) 
         [0171]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(n-butyl-amino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0172]    79) 
         [0173]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(pentylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0174]    80) 
         [0175]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(diethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0176]    81) 
         [0177]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-]-O-methyl-4-C-[(phenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0178]    82) 
         [0179]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-]-O-methyl-4-C-[(morpholinyl)methyl]-α-L-ribopyranosy)oxy]-2-ethyl -3,4,10-trihydroxy -3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0180]    83) 
         [0181]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-{[(5-amino-1,3,3-trimethyl-cyclohexylmethyl)-amino]-methyl}-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0182]    84) 
         [0183]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[piperonylamino-methyl)]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0184]    85) 
         [0185]    (2R,3S,4R,5S,8R, 10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-(fluorobenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosoxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0186]    86) 
         [0187]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1,2,3-triazolyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0188]    87) 
         [0189]    (2R,3S,4R,5S,8R,10R,11R, S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(ethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0190]    88) 
         [0191]    (2R,3S,4R,5S,8R,10R,11R,1S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(isopropylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0192]    89) 
         [0193]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(isobutylamino)methyl-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0194]    90) 
         [0195]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-chlorophenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0196]    91) 
         [0197]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(tert-butylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0198]    92) 
         [0199]    (2R,3S,4R5S,8R, 10R,11R, 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(n-hexylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0200]    93) 
         [0201]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-trifluoromethylbenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0202]    94) 
         [0203]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropyl-methylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0204]    95) 
         [0205]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-methoxy-benzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexatnethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0206]    96) 
         [0207]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(4-nitro-benzyl)aminol]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0208]    97) 
         [0209]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(6-dideoxy-3-C-methyl-3-O-methyl-4-C-[4-chloro-benzyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0210]    98) 
         [0211]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-pyridinyl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0212]    99) 
         [0213]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-]-O-methyl-4-C-[[(3-ethyoxyl-propyl)-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0214]    100) 
         [0215]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-methoxyethyl)-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0216]    101) 
         [0217]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(N-methyl-2-hydroxy-ethyl)amino-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,7,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0218]    102) 
         [0219]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-methoxy-benzyl)-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-ttihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0220]    103) 
         [0221]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopentyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0222]    104) 
         [0223]    (2R,3S,4R,5S,8R,10R,11R, S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2,4-difluorobenzyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-3-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0224]    105) 
         [0225]    (2R,3S,4R,5S,8R,10R,11R,1S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(6-chloro-pyridazin-3-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino -β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0226]    106) 
         [0227]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-hydroxy-butyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0228]    107) 
         [0229]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1-methyl-3-phenyl-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0230]    108) 
         [0231]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-methoxy-benzylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0232]    109) 
         [0233]    (2R,3S,4R5S,8R10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[piperazinyi-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl -7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0234]    110) 
         [0235]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[trifluoroacetylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosoxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0236]    111) 
         [0237]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[[(2-chloro-pyridin-4-yl-amino)-methyl]-amino]-mmethyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0238]    112) 
         [0239]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[4-formylbenzylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0240]    113) 
         [0241]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[propargyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0242]    114) 
         [0243]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[1-butyrate2-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0244]    115) 
         [0245]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[1-butyrate4-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0246]    116) 
         [0247]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[diglycol-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0248]    117) 
         [0249]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-hydroxy-1-hydroxyethyl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0250]    118) 
         [0251]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-hydroxy-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0252]    119) 
         [0253]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[n-pentyl-amino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0254]    120) 
         [0255]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methy)-3-O-methyl-4-C-[(morpholin-4-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0256]    121) 
         [0257]    (2R,3S,4R,5S,8R,10R,11S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-amino-butyrate)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0258]    122) 
         [0259]    (2R,3S,4R,5S,8R,10R,11S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1-hydroxymethyl-propylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0260]    123) 
         [0261]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-hydroxy-2-phenyl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0262]    124) 
         [0263]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,4-difluorophenylmethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0264]    125) 
         [0265]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C[(3,5-difluorophenylmethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-tri hydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0266]    126) 
         [0267]    (2R,3S,4R5S,8R10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-](2-methyethylamino)-methyl]α-L-ribropyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0268]    127) 
         [0269]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1-methyl-4-diethylaminobutylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4.10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0270]    128) 
         [0271]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[4-sulphonylamino-phenylethylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0272]    129) 
         [0273]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(1-methyl-but-1-ene-3-yne-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0274]    130) 
         [0275]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14)-13-[(,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(1-methyl-butyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0276]    131) 
         [0277]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(2-pyridin-4-yl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0278]    132) 
         [0279]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-{[(5-methyl-pyrazin-2-yl-methyl)-amino]-methyl}-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0280]    133) 
         [0281]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[[(cyclohexyl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-tri hydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0282]    134) 
         [0283]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl3-O-methyl-4-C-[(2-fluoro-phenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0284]    135) 
         [0285]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-morpholinyl-propyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0286]    136) 
         [0287]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-chloro-phenylmethyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0288]    137) 
         [0289]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-furyl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0290]    138) 
         [0291]    (2R,3S,4R,5S,8R,10R,11R,1S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-aminobenzyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0292]    139) 
         [0293]    (2R,3S,4R,5S,8R,10R,11R,1S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(phenylhydrazono)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacylclopentadecan-15-one; 
         [0294]    140) 
         [0295]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[{[2-(1H-indol-3-yl)-ethylamino]-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-he xopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0296]    141) 
         [0297]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-chloro-propyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyloxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0298]    142) 
         [0299]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,5-dimethoxyphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-]-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0300]    143) 
         [0301]    (2R,3S.4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2.6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-methyl-furan-2-O-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyt-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0302]    144) 
         [0303]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-fluoro-phenyihydrazono)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3.4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyloxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0304]    145) 
         [0305]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(benzyloxy-amino)-methyl]-α-L-ribopyranosyl.)oxy]-2-ethyl-3,4,10-trihydroxy-3.5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxyl-1-oxa-7-azacyclopentadecan-15-one; 
         [0306]    146) 
         [0307]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(p-methoxyphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0308]    147) 
         [0309]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,4-dimethylphenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0310]    148) 
         [0311]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4-fluorothiophenol)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0312]    149) 
         [0313]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-fluoropyridinyl-2-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0314]    150) 
         [0315]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(diethyl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-tri hydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0316]    151) 
         [0317]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-morpholinyl-propyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0318]    152) 
         [0319]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-pyrrolyl-ethyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-]]3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0320]    153) 
         [0321]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-](2-pyridin-4-yl-ethylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0322]    154) 
         [0323]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methy)-3-O-methyl-4-C-[(2-fluorobenzyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0324]    155) 
         [0325]    (2R,3S,4R,5S,8R,10R,11R, S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-piperidin-4-yl-methyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0326]    156) 
         [0327]    (2R,3S,4R,5S,8R,10R,11R, S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-methyl-4-chloro-phenyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0328]    157) 
         [0329]    (2R,3S,4R,5S,8R,10R,11R 2 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(N-methyl-butyl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0330]    158) 
         [0331]    (2R,3S,4R,5S,8R,10R,11R 2 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4,6-dichloro-pyrimidin-2-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0332]    159) 
         [0333]    (2R,3S,4R,5S,8R,10R,11R 2 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-](cycloheptylamino)-methyl]α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0334]    160) 
         [0335]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-(morpholinyl-methyl)-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3 4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0336]    161) 
         [0337]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(4,4-dimethoxy-butylamino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyloxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0338]    162) 
         [0339]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-(piperidin-4-yl-amino-methyl)-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0340]    163) 
         [0341]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(6-chloro-pyridin-3-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0342]    164) 
         [0343]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-(tetrahydropyrrolyl-methyl)-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0344]    165) 
         [0345]    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(5-hydrosulphonyl-1H-[1,2,4]triazol-3-yl-amino)-methyl]-α-L-ribopyranosyl)oxy]-2-ethy 1-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one; 
         [0346]    166) 
         [0347]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-amino-5-chloropyridinyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0348]    167) 
         [0349]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[N-ethylmethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,1 1R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0350]    168) 
         [0351]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(diallylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl -11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0352]    169) 
         [0353]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2,2,2-trifluoroacetamido)methyl]α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R.,11R.,12S,13S,14R)-1-oxa-7-azacycclopentadecan-15-one; 
         [0354]    170) 
         [0355]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-amino-2chloropyridinyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl -11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0356]    171) 
         [0357]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(benzamido)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R, 12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0358]    172) 
         [0359]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-trifluoromethylbenzylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0360]    173) 
         [0361]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3-bromophenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,1 I R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0362]    174) 
         [0363]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl -4-C-[(3-methoxyphenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0364]    175) 
         [0365]    13-[(2,6-di deoxy-3-C-methyl-3-O-methyl-4-C-[(p-iodophenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R, 12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0366]    176) 
         [0367]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2,4-dinitrophenylamino)etyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0368]    177) 
         [0369]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2,4-dimethylphenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0370]    178) 
         [0371]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(3,5-di(trifluoromethyl)phenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0372]    179) 
         [0373]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2,4-dichlorophenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0374]    180) 
         [0375]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-chlorophenylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylatnino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0376]    181) 
         [0377]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(allopurinol)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0378]    182) 
         [0379]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(1,2,4-triazolyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; 
         [0380]    183) 
         [0381]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(2-methylimidazotyl)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one; or 
         [0382]    184) 
         [0383]    13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(N-methyl-2-hydroxyethylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl -3,4,10-trihydroxy -3,5,8,10,12,14-hexamethyl-7-propyl -11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-(2R,3S,4R5S,8R,10R,11R,12S,13S,14R)-1-oxa-7-azacyclopentadecan-15-one. 
         [0384]    The present disclosure further provides a pharmaceutically acceptable salt of the compound described above. Preferably, the salt is prepared from the compound and an acid, and the acid is preferably selected from one or more of a group consisting of hydrochloric acid, oxalic acid, maleic acid, fumaric acid, citric acid, malic acid, isethionic acid, tartaric acid, methanesulfonic acid, ethanesulfonic acid, hydrobromic acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid, trifluoroacetic acid, benzoic acid, and p-toluenesulfonic acid. 
         [0385]    The present disclosure further provides a pharmaceutical composition for use in treatment of bacterial infections or protozoal infections in mammals, birds, or fish, comprising a therapeutically effective amount of the compound described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier thereof. 
         [0386]    The present disclosure further provides use of the compound described above or a pharmaceutically acceptable salt thereof in preparation of medicaments for the treatment of bacterial infections or protozoal infections in mammals, birds, or fish. 
         [0387]    The following synthetic routes describe the compounds as shown by formula (I) according to the present disclosure. All materials involved are prepared according to the process schematically shown by the synthetic routes, or process well known to one ordinary skilled in the organic chemistry field, or commercially available. All titled compounds according to the present disclosure are prepared according to the process schematically shown by the synthetic routes, which are well known to one ordinary skilled in the organic chemistry field. 
         [0388]    The compound shown by formula (I) according to the present disclosure can be prepared through the following route. 
         [0389]    The preparation process according to the present disclosure: 
         [0000]    
       
                 
         
             
             
         
       
     
         [0390]    Starting compound 222 can be synthesized according to processes recited in literature (Synthesis of 9-Deoxo-8a-aza-8a-homoerythromycin A by One-step, Chinese Journal of Synthetic Chemistry, volume 18, 2011, pages 265-268) and Chinese Patent CN1425022A, which are well known to the person skilled in the art. 
         [0391]    According to an embodiment of the present disclosure, C-2′ hydroxyl in compound 222 can be selectively protected by treating compound 222 with equivalent acetic anhydride in dichloromethane without external alkali, thus obtaining a compound of general formula 223 in which R 4  is acetyl. The compound of general formula 223 can be treated with methanol for 10-48 h at a temperature in a range from 23 to 65° C., so that acetyl protecting group can be removed. C-2′ hydroxyl can also be protected by other hydroxyl protecting group well known to the person skilled in the art, such as carboxybenzyl (Cbz). In the meantime, C-4″ hydroxyl would also be protected, which, however, does not influence subsequent experiments. C-2′ hydroxyl can be selectively protected using Cbz in one step by treating the compound of formula 222 with benzyl chloroformate in tetrahydrofuran and water. The Cbz group can be removed through conventional catalytic hydrogenation, or by reaction in a suitable organic solvent known in the art at a temperature in a range from room temperature to 100° C. for 2 h-5 days. In the following description, C-2′ hydroxyl and C-4″ hydroxyl are protected or deprotected in manners deemed suitable by the person skilled in the art. 
         [0392]    C-4″ hydroxyl of the compound of general formula 223 is oxidized. The oxidation of C-4″ hydroxyl is the focus of the synthesis of parent nucleus. C-4″ hydroxyl of the compound of general formula 223 is oxidized to a corresponding ketone through process well known to the person skilled in the art, including one or more processes described in Journal of Anti-biotics, 1988, pages 1029-1047. For example, the ketone of general formula 224 can be prepared from dimethylsulfoxide and suitable activating agent. Conventional reaction conditions for oxidation include: for example, a) Corey-kim oxidation (J. Med. Chem, 2001, 44 (24): 4137-4156), b) Jone&#39;s reagent (Bioorg. Med. Chem. Lett, 2006, 16 (3): 569-572), c) Dess-martin&#39;s reagent (US 2004/0254126), d) modified Pfitzner-maffat oxidation (J. Med. Chem, 1998, 41 (21): 4080-4100), e) Moffatt oxidation, in which N-ethyl-N′-(N,N-dimethylaminopropyl)carbodiimi de and dimethylsulfoxide react under the presence of trifluoroacetic acid pyridine onium salt, or f) Swern oxidation, in which oxalic acid chloride or trifluoroacetic anhydride reacts with dimethylsulfoxide in dichloromethane, followed by the addition of triethylamine. 
         [0393]    The oxidation of the compound of general formula 223 is preferably conducted by using dimethylsulfoxide, trifluoroacetic anhydride, and triethylamine. In the oxidation process, the protected compound is dissolved in a suitable solvent, such as dichloromethane, acetone, ethyl acetate, acetic acid isopropyl ester, and the like, preferably dichloromethane, at a temperature in a range from −78 to 50° C., preferably in a range from −78 to 60° C. Subsequently, trifluoroacetic anhydride is added, preferably dropwise, and reacted for 0-3 h. Afterwards, triethylamine is added dropwise and reacted for 0-3h. After the reaction is completed, an oxide, i.e. compound of general formula 224, can be obtained. 
         [0394]    Compound of general formula 225 can be obtained through either of the two following processes. 
         [0395]    In a first process (process A), compound of general formula 224 is treated with (CH 3 ) 3 S(O)X 2  wherein X 2 , is halogen, preferably iodine, —BF 4  or -—PF 6 , at a temperature in a range from 0 to about 60° C., under the presence of an alkali, such as potassium tert-butoxide, sodium tert-butoxide, sodium ethoxide, sodium hydride, 1,1,3,3-tetratnethyl guanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, 1,5-diazabicyclo[4.3.0]non-5-ene, potassium ethoxide, or sodium methoxide, preferably a sodium-containing alkali, such as sodium hydride, in a solvent, such as tetrahydrofuran, an ether solvent, N,N-dimethylformamide, or dimethylsulfoxide, or mixture of two or more of the above solvents, whereby compound of general formula 225 is obtained. 
         [0396]    In a second process(process B), compound of general formula 224 is treated with (CH 3 ) 3 SX 2  wherein X, is halogen, —BF 4  or —PF 6 , preferably —BF 4 , at a temperature in a range from −78 to about 60° C., under the presence of alkali, such as potassium tert-butoxide, sodium tert-butoxide, sodium ethoxide, sodium hydride, 1,1,3,3-tetramethyl guanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, 1,5-diazabicyclo[4.3.0]non-5-ene, potassium ethoxide, potassium hexatnethyldisilazide (KHMDS), or sodium methoxide, preferably KHMDS, in a solvent, such as tetrahydrofuran, an ether solvent, N,N-dimethylformamide, or dimethylsulfoxide, or mixture of two or more of the above solvents, whereby compound of general formula 225 is obtained. 
         [0397]    The term “halogen”, as used herein, unless otherwise indicated, includes fluorine, chlorine, bromine, or iodine. 
         [0398]    The term “alkyl”, as used herein, unless otherwise indicated, includes saturated monovalent hydrocarbon residue having straight, cyclic or branched moieties, or mixtures thereof. It is to be understood that where a cyclic moiety is mentioned, there are at least three carbon atoms present in said alkyl. Such cyclic moieties include cyclopropyl, cyclobutyl, and cyclopentyl. 
         [0399]    The term “alkoxy”, as used herein, unless otherwise indicated, includes —O-alkyl where alkyl is as defined above. 
         [0400]    The term “aryl”, as used herein, unless otherwise indicated, includes an organic residue derived from an aromatic hydrocarbon by removal of one hydrogen from the aromatic hydrocarbon, such as phenyl or naphthyl. 
         [0401]    The term “5-10 membered heteroaryl”, as used herein, unless otherwise indicated, includes aromatic heterocyclic groups containing one or more heteroatoms independently selected from O, S and N, wherein each heterocyclic group has 5-10 atoms in its ring system. Examples of suitable 5-10 membered heteroaryl groups include pyridyl, furyl, thienyl, pyrazolyl, (1,2,3)-and (1,2,4)-triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, and thiazolyl. 
         [0402]    The compounds of the present disclosure may have asymmetrical carbon atoms and therefore exist in different enantiomeric and diastereomeric forms. Diastereomeric mixtures can be separated into individual diastereomers based on the physical and chemical differences by methods well known in the art, such as chromatography or fractional crystallization. An enantiomer can be separated by converting the enantiomeric mixture into a diastereomeric mixture by reaction with a suitable optically active compound (such as alcohol), separated the diastereomers and converting individual diastereomers to the corresponding pure enantiomers. The use of all such isomers, including diastereomeric mixtures and pure enantiomers, are considered to be part of the present disclosure. 
         [0403]    Preferably, the bacterial and protozoal infections of the present disclosure, as well as human diseases related to such infections, include the following: pneumonia, trachitis, bronchitis, otitis media, sinusitis, amygdalitis, pharyngitis and nephritis related to infection by phthogenic  Streptococcus suis, Haemophilus influenza, Moraxella, Staphylococcus aureus, Legionella, Actinobacillus, Mycoplasma , and  Chlamydia ; fever and skin and soft tissue infections, abscesses and osteomyelitis related to infection by pathogenic  Staphylococcus, Streptococcus , and  Corynebacterium ; diseases of the genitourinary system, such as urethritis, cervicitis, gonorrhea infection, and sexually transmitted diseases, related to infection by pathogenic  Staphylococcus, Enterococcus, Chlamydia, Spirochaeta, Mycoplasma , and  Neisseria ; Lyme disease related to infection by  borrelia burgdorferi ; conjunctivitis, keratitis and dacryocystitis related to infection by  Chlamydia trachomatis, Neisseria gonorrhoeae, Staphylococcus aureus, Streptococcus pneumonia, Streptococcus pyogenes, Hemophilus influenza , or  Listeria  spp.; gastroenteritis related to infection by  Campylobacter jejuni  or anabrosis related to infection by  Helicobacter pylori ; intestinal protozoa related to infection by  Crytosporiduum  spp.; odontogenic infection related to infection by  Viridans streptococci ; persistent cough related to infection by  Bordetella pertussis ; gas gangrene related to infection by  Clostridium perfringens  or  Bacteroids  spp.; and arteriosclerosis related to infection by  Helicobacter pylori  or  Chlamydia pneumoniae.    
         [0404]    Preferably, the animal bacterial infections and protozoal infections that can be prevented and treated according to the present disclosure, as well as diseases related to such infections, include the following: bovine respiratory diseases related to infection by  Pasteurella hemolytica, Pasteurella multocida, Mycoplasma bovis , or  Bordetella  spp.; bovine enteric diseases related to infection by  Escherichia coli  or protozoa (such as coccidia); dairy cow mastitis related to infection by  Staphylococcus aureus, Streptococcus uberis, Streptococcus agalactiae, Streptococcus dysgalactiae, Klebsiella  spp.,  Corynebacterium  and  Enterococcus ; bovine or swine hysteritis related to infection by  Escherichia coli ; infectious conjunctivitis related to infection by  Moraxella bovis ; cow premature abortion related to infection by protozoa (i.e., nesporium); swine respiratory diseases related to infection by  Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus , and  Mycoplasma ; blood protozoonoses related to infection by protozoa (such as toxoplasm, eperythrozoon); swine enteric diseases related to infection by  E.coli, Salmonella  and  spirochaeta ; swine septicemia, skin inflammation, and joint swell, necrosis and pyosis related to infection by  Bacillus etysipelatos - suis, Streptococcus suis  and  Bacillus anthracis ; urinary tract infections in dogs and cats related to infection by  E. coli ; skin and soft tissue infections in dogs and cats related to infection by  Staph. epidermidis, Staph. intermedius , coagulase neg.  Staph  or  P. multocida ; dental or mouth infections in dogs and cats related to infection by  Alkaligenes. Bacteroides, Clostridium, Enterobacter  spp.,  Eubacterium, Peptostreptococcus, Porphyromonas  and  Prevotella ; enteric diseases in birds related to infection by  E. coli, Salmonella  and  Clostridium welchii ; septicemia and parenchymatous organs and mucous membrane inflammations of skin, soft tissues and internal organs in birds related to infection by  E. coli, Pasteurella, Staphylococcus  and  Streptococcus ; protozoosis related to protozoa (such as  coccidium  and  Leucocytozoosis ); and respiratory diseases related to infection by  Mycoplasma, Haemophilus  and  E. coli.    
         [0405]    A therapeutic dose of the effective amount according to the present disclosure is 2-50 mh/kg per single dose. 
         [0406]    The term “pharmaceutically acceptable salt(s)” as used herein, unless otherwise indicated, includes salts of acidic or basic groups which may be present in the compounds of the present disclosure. The compounds of the present disclosure that are basic in nature are capable of forming a wide variety of salts with various inorganic or organic acids. Acids that may be used to prepare the pharmaceutically acceptable salts of such basic compounds are those that form acid addition salts, i.e., salts containing pharmaceutically acceptable anions, such as, formate, acetate, propionate, lactate, citrate, tartrate, oxalate, malate, hydrochloride, sulfate, nitrate, hydrosulfate, phosphate, acid phosphate, nicotinate, salicylate, pantothenate, ascorbate, succinate, maleate, gentisic acid, fumarate, gluconate, glucarate, saccharate, benzoate, glutamate; mesylate, esilate, benzene sulfonate, tosilate, and various amino acids according to the present disclosure. The compounds of the present disclosure that are acid in nature are capable of forming basic salts with various pharmaceutically acceptable positive ions. The salts include alkali metals and alkaline earth, such as calcium, magnesium, sodium and potassium, and the like, 
         [0407]    According to the present disclosure, the pharmaceutical composition for treatment of bacterial or protozoal infections in mammals, birds, or fish, comprises the compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient, and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier refers to any diluent or adjuvant that can be used in pharmaceutical field. 
         [0408]    Dosage form of the pharmaceutical composition of the present disclosure can be oral preparations, injection, or external preparations. 
         [0409]    Preferably, the oral preparations according to the present disclosure can be powder, tablets, capsules, granules, liquores, and suspensoid. The injection preparations can be powder injection, emulsion, suspensoid, and liquors. The external preparations can be ointment and drops. 
         [0410]    The cartier in the pharmaceutical composition according to the present disclosure refers to adjuvant ingredients necessary in the preparations in the pharmaceutical field, including diluents, cosolvent, antioxidant, corrigent, preservative, excipient, and coagulant. 
     
    
     DETAILED DESCRIPTION OF THE EMBODIMENTS 
       [0411]    Examples are provided to further illustrate the process and intermediates according to the present disclosure. Nevertherless, the following examples are not intended to limit the scope of the present disclosure. 
         [0412]    A synthetic route involved in examples 1 to 80 of the present disclosure is shown as follows. 
         [0000]    
       
                 
         
             
             
         
       
     
       EXAMPLE 1 
       [0413]    A cryostat was turned on, and the temperature was set at −12° C. 500 ml dichloromethane was measured with a 1 L graduated cylinder and added into a 1.0 L three-necked bottle. The three-necked bottle was placed in the cryostat to be cooled under agitation. 50 g (0.068 mol) of compound 2 was weighed with a counter balance and added into the reaction flask, and 300 ml of dichloromethane was measured with the 1 L graduated cylinder and added therein. The mixture was stirred, dissolved and cooled. An inner temperature of the reaction flask was cooled to 0-5° C. To the reaction solution, the temperature of which is kept at 0-5° C., was slowly added dropwise a mixed solution of 11.98 ml of benzyl chloroformate and 60 ml of dichloromethane. After the addition of the mixed solution, the reaction was carried out under the same temperature for 1 h. The reaction progress was monitored through thin layer chromatography (developing solvent: dichloromethane/methanol=10:1, with addition of two drops of ammonia). After the reaction was completed, the resulting reaction solution was concentrated under vacuum (with a temperature being ≦50° C. and a vacuum degree being ≦−0,086 Mpa) to give about 300 ml of compound 3. 
         [0414]    TLC Rf=0.42 (dichloromethane: methanol=7:1). 
         [0415]    ESI/MS: m/z 869[M+H] + . 
       EXAMPLE 2 
       [0416]    A low temperature cooling device was turned on, and the temperature was set at −75° C. Temperature was cooled to a range from −70 to −60° C. The 300 ml compound 3 liquid obtained from the concentration according to example 1 was transferred to a 1.0 L three-necked reaction flask. 106.46 ml (117.11 g or 1.498 mol) of dimethyl sulfoxide was added into the reaction flask under room temperature (25-30° C.). After dimethyl sulfoxide was added, the reaction flask was placed in the cryostat to be cooled under agitation to a temperature in a range from −70 to 60° C. 21.55 ml (0.152 mol or 31.865 g) of trifluoroacetic anhydride was slowly added dropwise, a dropping speed thereof being controlled, so that a temperature of the reaction solution can be maintained in a range from −65 to −60° C. The reaction was carried out under the same temperature for 0.5 h. Under the condition that the temperature of the reaction solution was maintained in the range from −65 to −60° C., 47.3 ml (0.339 mol, 34.35 g) of triethylamine was slowly added dropwise, and then stirred for 0.5 h under the same temperature. After the completion of the reaction, the reaction solution was warmed to the room temperature. The reaction liquid at room temperature (20-30° C.) was transferred to a 2.0 L separating funnel, into which 350 ml of putified water was added. After extraction, a water layer was discarded and an organic layer was obtained. The organic layer was extracted again with 250 ml of saturated sodium bicarbonate solution, from which an organic layer was obtained and a water layer was discarded. The organic layer obtained was extracted again with 350 ml of purified water, from which a water layer was discarded and an organic layer is obtained. The organic layer was transferred to a 1.0 L beaker, into which 20 g of anhydrous magnesium sulfate was added. After agitation for 20 minutes, the mixture in the beaker is dried and dehydrated. Then, magnesium sulfate was filtered out, and pale yellow filtrate was obtained. The pale yellow filtrate was concentrated to a volume of 125 ml under vacuum, with a temperature being ≦60° C. and a vacuum degree being ≦−0.086 Mpa. To the concentrate, was added 135 ml of isopropanol, and concentrated again to a volume of 135 ml. The liquid finally obtained from the concentration was transferred into the 1.0 L three-necked reaction flask. 700 ml of tert-butyl methyl ether was added into the reaction flask, and 11.2 ml (0.1497 mol, 17.07 g) of trifluoroacetic acid was slowly added therein dropwise at room temperature. The resulting mixture was crystallized under stirring at room temperature. After suction filtration, the filter cake was washed with n-heptane (200 ml×2) by stirring for 30 min. The filter cake was dried by forced air at 30° C., to afford 8.2 g of compound 4, with a yield of 82.2% and HPLC purity of 91% (applying HPLC-Waters Symmetry C8, 15 cm×3.9mm column, Mobile Phase: methanol: ammonium acetate (25:75), Flow rate: 2,0 mL/min, Residence time: 5.07 min). 
         [0417]    TLC Rf=0.39 (dichloromethane: methanol=7:0). 
         [0418]    ESI/MS: m/z 867[M+H] 
       EXAMPLE 3 
       [0419]    To a 3.0 L beaker were added 50 g (0.0456 mol) of compound 4 of example 2 and 80 ml of dichloromethane. After uniform mixing, the solution was dried with 15 g of anhydrous magnesium sulfate for 20 min and then filtered by suction filtration. The filtrate was dried for the second time with 7 g of anhydrous magnesium sulfate for 20 min and then filtered by suction filtration. The filter residue, which was washed with dichloromethane, and the filtrate, which was refilled with dichloromethane to a volume of 160 ml (the measured content of moisture in the filtrate should be less than 0.3%) were reserved for later use. A low temperature cooling device was turned on and set at −8° C. 170 ml of tetrahydrofuran (dried with anhydrous magnesium sulfate for 30 min and filtered by suction filtration) was added into a 1.0 L three-necked bottle. The three-necked bottle was placed in a cryostat to be cooled under agitation to a temperature in a range from −5 to 0° C. 20 g (0.1273 mol) of trimethylsulfonium bromide was added into the three-necked bottle, and 20 g (0.11.786 mol) of potassium tert-butoxide was added therein at −5-0° C. After being vacuumized by a circulating water pump, the three-necked bottle was filled with nitrogen. The reaction mixture was stirred for for 15 min under nitrogen atmosphere. The temperature of the low temperature cooling device was adjusted to −75° C., and an inner temperature thereof was reduced to a range from −65 to −60° C. The solution, which has been deoxidized and dried, was slowly added into the reaction flask dropwise, meanwhile timekeeping begun. In this course, the temperature of the reaction solution was kept in a range from −65 to −60° C. After the addition of the solution, the reaction was carried out at −65 to −60° C. till the timekeeping reached 3 h. Reaction progress was monitored by thin layer chromatography (developing solvent: dichloromethanelmethanol=10:1, with addition of two drops of ammonia). After the reaction was completed, to the reaction mixture was added a solution of 21.5 g (0.405mol) of ammonium chloride in 120 ml of water. The resulting mixture was stirred for 15 min at 5-10° C. After stratification, the water layer was extracted once with 200 ml of dichloromethane; and organic phases were combined, and washed with water for four times (4×100 ml). The organic layer was concentrated under vacuum until no more distillate was observed. Remaining solvent was vaporized by being substituted with 200 ml methanol. After two substitutions, the solution was concentrated, thereby obtaining compound 5. 
         [0420]    TLC Rf=0.55(dichloromethane: methanol=8:1). 
         [0421]    ESI/MS: m/z 881 [M+H] + . 
       EXAMPLE 4 
       [0422]    Compound 5 prepared in example 3 was dissolved in 350 ml of methanol and transferred to a 1.0 L three-necked bottle. 16 g of palladium and 142 g (0.2246 mol) of ammonium formate were added into the three-necked bottle. The reaction was carried out at 50° C. for 2 h. Reaction progress was monitored by thin layer chromatography (developing solvent: dichloromethane/methanol=10:1, with addition of two drops of ammonia). After the reaction was completed, the reaction solution was cooled to lower than 30° C., and then filtered by suction. The filtrate was concentrated under vacuum until about 200 ml of mixture remained, and the filter cake was kept sealed with water. The concentrate was slowly added into 550 ml of water dropwise within 20 min, and crystallized under stirring for 1 h. After suction filtration, the filter cake was washed with methanol/water (1:3), and then dried, to afford compound 6 (applying WATERS ACQUITY UPLC BEH C18 chromatographic column (2.1×50 mm, 1.7 μm); Mobile phase: acetonitrile-0.01 moL/L ammonium acetate in water (55:45), Flow rate: 0.20 mL/min, Residence time: 2.77 min, Detecting wavelength: 210 nm, Column temperature: 40° C., and Inj. Vol: 2.5 μl). 
         [0423]    TLC Rf=0.45(dichloromethane: methanol=7:1). 
         [0424]    ESI/MS: m/z 747[M+H] + . 
       EXAMPLE 5 
     General Preparation Process 1 
       [0425]    Preparation of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropylamino)methyl]-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0426]    Compound 6 (0.5 g, 0.6698 mmol), potassium iodide (1.11 g, 0.698 mmol) and cyclopropylamine (2.43 mL, 2.00 g, 35 mmoL) were dissolved under vibration at 50° C. in 5 ml isopropanol in a 50 ml round-bottom flask, and the resulting mixture was stirred at 50° C. Reaction progress was monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and the residue was dissolved in water (50 ml) and ethyl acetate (100 ml). After standing stratification, the water layer was washed with ethyl acetate (3×50 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (50 ml) and brine (40 ml), dried with anhydrous sodium sulfate, and filtered. The filtrate was concentrated under vacuum to afford crude product. The crude product was purified by silica gel chromatograph (gradient of eluents of methanol:dichloromethane: ammonia water from 4:95.6:0.4 to 6:93.5:04) to afford 0.38 g of the titled compound (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C -[(cyclopropylamino)methyl]-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0427]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0428]    ESI/MS: m/z 805[M+H] + . 
       General Preparation Process 2 
       [0429]    Preparation of (2R,3S,4R,5S,8R, 10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(butylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideox y-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one, 
         [0430]    Compound 6 (0.5 g, 0.6698 mmol), tetrabutylammonium iodide (0.74, 2.0 mmoL) and n-butylamine (0.395 mL, 0.2938, 4 mmoL) were dissolved under vibration in 5 ml methanol at 50° C., and the resulting mixture was stirred at the same temperature. Reaction progress was monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and residue was dissolved in 20 ml of water and 20 ml of ethyl acetate. After standing stratification, the water layer was washed with ethyl acetate (3 ×20 ml). The organic extractants were combined and washed with 40 ml of brine, dried with anhydrous sodium sulfate, and filtered. The filtrate was concentrated under vacuum, thereby obtaining crude product. The crude product was purified by silica gel chromatograph (gradient of eluents of methanol:dichloromethane: ammonia water from 4:95.6:0.4 to 6:93.5:0.4) to afford 0. 0888 g of the tiltled compound (2R,3S,4R,5S,8R,10R,11R, 12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(butylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0431]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0432]    ESI/MS: m/z 819 [M+H] + . 
       General Preparation Process 3 
       [0433]    Preparation of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C -[(propylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexatnethyl-11-[[3,4,6-trideoxy -3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa -7-azacyclopentadecan-15-one. 
         [0434]    Compound 6 (0.5 g, 06694 mmol) and n-propylamine (0.5 g) were dissolved under vibration in isopropanol (10 ml) at 50° C., and the resulting mixture was stirred at the same temperature for 48 h. Reaction progress is monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and residue was added into saturated sodium bicarbonate solution (50 ml) and dichloromethane (80 ml). The mixture was vibrated uniformly, and stood to be stratified. The organic phase dichloromethane was washed with water (3 ×50 ml), dried with MgSO 4 , and concentrated under vacuum to dryness. The resulting substance was dissolved in dichloromethane, and applied on GF254 silica gel. Thin layer chromatography separation was performed with an eluent of 4/1 cyclohexaneldiethylamine or 4/1/0.01 dichloromethane/methanol/amtnonia water. The chromatographic band corresponding to the desired product was scraped off and further purified by silica gel chromatography eluted with a mixture of dichloromethanelmethanollammonia in a ratio of 4/1/0.01. The mobile phase was concentrated at 50° C. under vacuum and dried, thereby obtaining 0.16 g of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one as pure amine. 
         [0435]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0436]    ESI/MS: m/z 807[M+H] + . 
         [0437]    Compounds according to examples 5 to 80 have structures shown by the following general formula 1. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0438]    In examples 5 to 80, R is a group shown by Table 1, and nitrogen or sulfur in R is directly attached to methylene of R 3 . R′ in each of examples 5 to 80 is H. Specific reaction time for each of compounds of examples 6 to 80 prepared according to the above general preparation process 1, general preparation process 2 and general preparation process 3 of example 5 is shown in Table 1. In Table 1, data relating to structures, yields and mass spec are the data of the final compounds. 
         [0000]    
       
         
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                 Mass 
               
               
                   
                 Compound 
                   
                 Preparation 
                 Reaction 
                 Yield 
                 spec 
               
               
                 Example 
                 No. 
                 R 
                 process 
                 time, h 
                 % 
                 M + H 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                  5 (general 
                 syzx-1 
                 n-propylamino 
                 general 
                 48 
                 50 
                 807 
               
               
                 preparation 
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process 3) 
                   
                   
                 process 3 
                   
                   
                   
               
               
                  5 (general 
                 syzx-2 
                 n-butylamino 
                 general 
                 53 
                 45 
                 819 
               
               
                 preparation 
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process 2) 
                   
                   
                 process 2 
                   
                   
                   
               
               
                  6 
                 syzx-3 
                 diethylamino 
                 general 
                 36 
                 60 
                 820 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                  7 
                 syzx-4 
                 phenylamino 
                 general 
                 36 
                 58 
                 840 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                  8 
                 syzx-5 
                 morpholinyl 
                 general 
                 36 
                 42 
                 834 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                  5 (general 
                 syzx-6 
                 cyclopropylamino 
                 general 
                 36 
                 46 
                 805 
               
               
                 preparation  
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process 1) 
                   
                   
                 process 1 
                   
                   
                   
               
               
                  9 
                 syzx-7 
                 pyrryl 
                 general 
                 36 
                 59 
                 814 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 10 
                 syzx-8 
                 4-fluorobenzylamino 
                 general 
                 36 
                 58 
                 872 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 11 
                 syzx-9 
                 1-imidazolyl 
                 general 
                 36 
                 32 
                 815 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 12 
                 syzx-10 
                 ethylamino 
                 general 
                 36 
                 40 
                 792 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 13 
                 syzx-11 
                 isopropylamino 
                 general 
                 48 
                 33 
                 806 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 14 
                 syzx-12 
                 isobutylamino 
                 general 
                 48 
                 35 
                 820 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 15 
                 syzx-14 
                 tert-butylamino 
                 general 
                 48 
                 51 
                 820 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 16 
                 syzx-15 
                 piperidinylamino 
                 general 
                 48 
                 55 
                 832 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 17 
                 syzx-17 
                 cyclopropylmethylamino 
                 general 
                 48 
                 70 
                 818 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 18 
                 syzx-18 
                 4-methoxybenzylamino 
                 general 
                 48 
                 55 
                 884 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 19 
                 syzx-20 
                 4-chlorobenzylamino 
                 general 
                 48 
                 52 
                 888 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 20 
                 syzx-21 
                 3-pyridinylmethylamino 
                 general 
                 48 
                 60 
                 855 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 21 
                 syzx-22 
                 (3-ethoxypropyl)amino 
                 general 
                 48 
                 33 
                 850 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 22 
                 syzx-24 
                 dimethylamino 
                 general 
                 48 
                 33 
                 792 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 23 
                 syzx-25 
                 (2-methoxyethyl)amino 
                 general 
                 48 
                 44 
                 822 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 24 
                 syzx-27 
                 2-methoxybenzyl-amino 
                 general 
                 72 
                 50 
                 884 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 25 
                 syzx-29 
                 2-[(N-methyl)amino]-ethyl)amnino 
                 general 
                 72 
                 33 
                 821 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 26 
                 syzx-30 
                 cyclopentylamino 
                 general 
                 72 
                 35 
                 832 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 27 
                 syzx-31 
                 2,4-difluoro-benzyl-amino 
                 general 
                 72 
                 36 
                 890 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 28 
                 syzx-32 
                 6-chloro-pyridazin-3-yl-amino 
                 general 
                 72 
                 44 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 29 
                 syzx-34 
                 (1-methyl-3-phenyl)propyl-amino 
                 general 
                 72 
                 23 
                 896 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 30 
                 syzx-35 
                 3-methoxybenzyl-amino 
                 general 
                 72 
                 26 
                 884 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 31 
                 syzx-37 
                 2,2,2-trifluoroacetyl-amino 
                 general 
                 72 
                 56 
                 860 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 32 
                 syzx-38 
                 2-chloro-pyridin-4-yl-amino 
                 general 
                 72 
                 60 
                 875 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 33 
                 syzx-39 
                 4-formyl-benzyl-amino 
                 general 
                 72 
                 23 
                 898 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 34 
                 syzx-40 
                 propargyl-amino 
                 general 
                 72 
                 45 
                 802 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 35 
                 syzx-41 
                 butyrate-2-amino 
                 general 
                 72 
                 56 
                 850 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 36 
                 syzx-42 
                 butyrate-4-amino 
                 general 
                 72 
                 60 
                 850 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 37 
                 syzx-46 
                 3-hydroxy-propylamino 
                 general 
                 72 
                 56 
                 822 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 38 
                 syzx-47 
                 n-pentyl-amino 
                 general 
                 72 
                 57 
                 834 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 39 
                 syzx-48 
                 morpholin-4-yl-amino 
                 general 
                 72 
                 23 
                 849 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 40 
                 syzx-50 
                 butyrate-3-amino 
                 general 
                 72 
                 26 
                 850 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 41 
                 syzx-51 
                 1-hydroxymethyl-propylamino 
                 general 
                 72 
                 66 
                 836 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 42 
                 syzx-52 
                 2-hydroxy-2-phenyl-ethylamino 
                 general 
                 72 
                 77 
                 884 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 43 
                 syzx-56 
                 4-dimethoxy-butylamino 
                 general 
                 72 
                 50 
                 880 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 44 
                 syzx-57 
                 3,4-dichloro-benzylamino 
                 general 
                 72 
                 45 
                 923 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 45 
                 syzx-58 
                 2-methoxyethylamino 
                 general 
                 48 
                 44 
                 822 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 46 
                 syzx-59 
                 1-methyl-4-dimethylamino- 
                 general 
                 72 
                 36 
                 905 
               
               
                   
                   
                 butylamino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 47 
                 syzx-60 
                 (3-cyclohexylamino)propylamino 
                 general 
                 72 
                 37 
                 903 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 48 
                 Syzx-61 
                 4-sulfamido-phenethylamino 
                 general 
                 72 
                 38 
                 947 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 49 
                 syzx-62 
                 1-methyl-but-1-en-3-yne-amino 
                 general 
                 72 
                 44 
                 828 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 50 
                 syzx-63 
                 1-methyl-butyl-amino 
                 general 
                 72 
                 25 
                 834 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 51 
                 syzx-64 
                 2-pyridin-4-yl-ethylamino 
                 general 
                 72 
                 27 
                 869 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 52 
                 syzx-65 
                 (2-methyl-pyrazin-5-yl-methyl)- 
                 general 
                 72 
                 28 
                 870 
               
               
                   
                   
                 amino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 53 
                 syzx-66 
                 3-methoxy-propyl-amino 
                 general 
                 72 
                 29 
                 836 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 54 
                 syzx-67 
                 cyclohexyl-methyl-amino 
                 general 
                 72 
                 30 
                 860 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 55 
                 syzx-68 
                 2-fluoro-phenyl-amino 
                 general 
                 72 
                 33 
                 858 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 56 
                 syzx-69 
                 3-morpholinyl-propyl-amino 
                 general 
                 72 
                 63 
                 891 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 2 
                   
                   
                   
               
               
                 57 
                 syzx-71 
                 2-furfuryl-amino 
                 general 
                 72 
                 38 
                 844 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 58 
                 syzx-72 
                 3-aminobenzyl-amino 
                 general 
                 72 
                 39 
                 869 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 59 
                 syzx-73 
                 phenylhydrazono 
                 general 
                 72 
                 50 
                 855 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 60 
                 syzx-74 
                 2-(1H-indol-3-yl)-ethylamino 
                 general 
                 72 
                 23 
                 907 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 61 
                 syzx-75 
                 3-chloropropyl-amino 
                 general 
                 72 
                 46 
                 840 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 62 
                 syzx-76 
                 3,5-dimethoxyphenyl-amino 
                 general 
                   
                   
                   
               
               
                   
                   
                   
                 preparation 
                 72 
                 44 
                 900 
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 63 
                 syzx-77 
                 thienylformyloxymethyl-2-amino 
                 general 
                 72 
                 43 
                 904 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 64 
                 syzx-78 
                 5-methylfurfurylamino 
                 general 
                 72 
                 48 
                 858 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 65 
                 syzx-81 
                 4-fluoro-phenylhydrazono 
                 general 
                 72 
                 25 
                 873 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 66 
                 syzx-82 
                 benzyloxy-amino 
                 general 
                 72 
                 30 
                 870 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 67 
                 syzx-83 
                 p-methoxyphenyl-amino 
                 general 
                 72 
                 21 
                 870 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 68 
                 syzx-84 
                 3,4-dimethylphenyl-amino 
                 general 
                 72 
                 25 
                 868 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 69 
                 syzx-86 
                 5-fluoropyridin-2-yl-amino  
                 general 
                 72 
                 16 
                 859 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 70 
                 syzx-90 
                 2-pyrrolyl-ethyl-amino  
                 general 
                 72 
                 33 
                 861 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 71 
                 syzx-91 
                 2-pyridin-4-yl-ethylamino 
                 general 
                 72 
                 32 
                 869 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 72 
                 syzx-92 
                 2-fluorobenzyl-amino 
                 general 
                 72 
                 33 
                 872 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 73 
                 syzx-93 
                 2-piperidin-4-yl-methyl-amino  
                 general 
                 72 
                 36 
                 861 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 3 
                   
                   
                   
               
               
                 74 
                 syzx-94 
                 5-chloro-o-methylphenyl-amino 
                 general 
                 72 
                 11 
                 888 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 75 
                 syzx-95 
                 2-fluoro-phenyl-amino 
                 general 
                 72 
                 10 
                 858 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 76 
                 syzx-96 
                 2-fluoro-5-methylphenyl-amino 
                 general 
                 72 
                 10 
                 872 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 77 
                 syzx-97 
                 2-methyl-4-chloro-phenyl-amino 
                 general 
                 72 
                 13 
                 888 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 78 
                 syzx-98 
                 N-methyl-butyl-amino 
                 general 
                 72 
                 23 
                 834 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 79 
                 syzx-99 
                 quiriolin-6-yl-amino 
                 general 
                 72 
                 12 
                 891 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 80 
                 syzx-100 
                 1,2,2-trimethyl-propylamino  
                 general 
                 72 
                 18 
                 848 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
               
               
                   
               
             
          
         
       
     
         [0439]    The following examples relate to compounds and preparation thereof when R′ in formula (I) is n-propyl, 
         [0000]    
       
                 
         
             
             
         
       
     
       EXAMPLE 81 
       [0440]    600 ml of dichloromethane was added into a 2 L three-necked bottle. The three-necked bottle was placed in the cryostat to be cooled under agitation. 30 g (0.3861 mol) of compound 11, which was prepared according to the process as described in Chinese patent CN102239174A, was measured and added into the reaction flask to be dissolved under stirring, and then cooled to 0-5° C. To the reaction solution, the temperature of which is kept at 0-5° C. ;  was slowly added dropwise a mixed solution of 6.8 ml (0.424 mol, 82.32 g) of benzyl chloroformate and 60 ml of dichloromethane. After the addition of the mixed solution, the reaction was carried out under 0-5° C. for 1 h. The reaction solution was concentrated under vacuum, with a temperature being ≦50° C. and a vacuum degree being ≦−0.086 Mpa, to give 180 ml of concentrate of compound 7. The concentrate of compound 7 was transferred to the 2 L three-necked reaction flask, into which 60.6 ml (66.6 g, 8.532 mol) of dimethyl sulfoxide was added at room temperature (20-30° C.). After dimethyl sulfoxide was added, the reaction flask was placed in the cryostat to be cooled under agitation to a temperature in a range from −70 to −60° C. 12.18 ml (0.864 mol, 181.32 g) of trifluoroacetic anhydride was slowly added dropwise, a dropping speed thereof being controlled, so that a temperature of the reaction solution can be maintained in a range from −65 to −60° C. The reaction was carried out at the same temperature for 0.5 h. Under the condition that the temperature of the reaction solution was maintained in the range from −65 to −60° C., 26.88 ml (1.932 mol, 195.3 g) of triethylamine was slowly added dropwise, and then stirred for 0.5 h at the same temperature. 
         [0441]    After the reaction was completed, the reaction solution was warmed to the room temperature, and then transferred to a 2 L separating funnel, into which 210 ml of purified water was added. After extraction, an organic layer was obtained and a water layer was discarded. The organic layer was extracted again with 150 mL of saturated sodium bicarbonate solution, from which an organic layer was obtained and a water layer was discarded. Again, the organic layer obtained was extracted with 200 ml of purified water, from which a water layer was discarded and an organic layer was obtained. 
         [0442]    The organic layer was transferred to a 1.0 L beaker, into which 120 g of anhydrous magnesium sulfate was added. After agitation for 20 minutes, the mixture in the beaker is dried and dehydrated. Then, magnesium sulfate was filtered out, and pale yellow filtrate was obtained. The pale yellow filtrate was concentrated under vacuum to dryness, with a temperature being ≦60° C. and a vacuum degree being ≦−0.086 Mpa, to afford compound 8. 
         [0443]    TLC Rf=0.60 (dichloromethane: methanol=7:1). 
         [0444]    ESI/MS: m/z909[M+H] + . 
       EXAMPLE 82 
       [0445]    170 ml of tetrahydrofuran was added into a 1.0 L three-necked bottle. The three-necked bottle was placed in a cryostat to be cooled under agitation to a temperature in a range of −5-0° C. Trimethylsulfonium bromide (0.12256 mol, 19.25 g) was added into the three-necked bottle, and potassium tert-butoxide (0.17156 mol, 19.25 g) was added therein at −5-0° C. The reaction mixture was stirred for 15 min under nitrogen atmosphere. An inner temperature was reduced to −70° C., and a dichloromethane solution of compound 8 prepared according to example 81 was slowly added dropwise into the three-necked bottle, meanwhile timekeeping begun. In this course, the temperature of the reaction solution was kept in a range from −65 to −60° C. After the addition of the solution, the reaction was carried out under nitrogen atmosphere till the timekeeping reached 3 h. 
         [0446]    To the reaction solution was added a solution of 20.85 g (0.39 mol, 20.85 g) of ammonia chloride in 120 ml of water. The resulting mixture was stirred for 15 min at 5-10° C. After stratification, the water layer was extracted once with 200 ml of dichloromethane. The dichloromethane layer and the organic phase were combined, and washed with water (4×200 ml). The organic layer was concentrated under vacuum until no more distillate was observed. Remaining solvent was vaporized by being substituted with 200 ml methanol. After two substitutions, the solution was concentrated, thereby obtaining compound 9. 
         [0447]    TLC Rf=0.58(dichloromethane: methanol=7:1). 
         [0448]    ESI/MS m/z923[M+H] + . 
       EXAMPLE 83 
       [0449]    Compound 9 prepared in example 82 was dissolved in 170 ml of methanol. 16 g of palladium and 13.63 g (0.2164 mol, 13.63 g) of ammonium formate were added into the resulting solution. The reaction was carried out at 50° C. for 2 h. After the reaction was completed, the reaction solution was cooled and then filtered. The filter cake was kept sealed with water, and the filtrate was concentrated under vacuum until about 80 ml of mixture remained. The concentrate was slowly added dropwise into 250 ml of water within 20 min. The concentrate was regulated with 10% sodium hydroxide solution until the pH thereof reached 10.5±0.5, and crystallized under stirring for 1 h. After suction filtration, the filter cake was washed with methanol/water (1:3), and then dried under forced air at 40° C., thereby affording compound 10. 
         [0450]    TLC Rf=0.33(dichloromethane: ethanol=7:1). 
         [0451]    ESI/MS: m/z789[M+H] + . 
       EXAMPLE 84 
     General Preparation Process (a) 
       [0452]    Preparation of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(cyclopropylamino)-methyl]-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-tri&#39;hydroxy-8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0453]    In a 50 ml round-bottom flask, compound 10 (0.5 g, 0.6698 mmol) prepared according to example 83, potassium iodide (1.11 g, 0.698 mmol) and cyclopropylamine (2.43 mL, 2.00 g, 35 mmoL) were dissolved under vibration at 50° C. in 5 ml of isopropanol, and the resulting mixture was stirred at 50° C. Reaction progress was monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and the residue was dissolved in water (50 ml) and ethyl acetate (100 ml). After stratification, the water layer was washed with ethyl acetate (3×50 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (50 ml) and brine (40 ml), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under vacuum to afford a crude product. The crude product was purified by silica gel chromatograph (gradient of eluents of methanol: dichlorotnethane: ammonia water from 4:95.6:0.4 to 6:93.5:0.4) to afford 0.38 g of the titled corn pound. 
         [0454]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0455]    ESI/MS: m/z 846[M+H] + . 
       General Preparation Process (b) 
       [0456]    Preparation of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(n-butylamino)-methyl]-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0457]    Compound 10 (0.5 g, 0.6698 mmol) prepared according to example 83, tetrabutylammonium iodide (0.74, 2.0 mmoL) and n-butylamine (0.395 mL, 0.2938, 4 mmoL) were dissolved under vibration in 5 ml methanol at 50° C., and the resulting mixture was stirred at the same temperature. Reaction progress was monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and the residue was dissolved in water (20 ml) and ethyl acetate (20 ml). After stratification, the water layer was washed with ethyl acetate (3×20 ml). The organic extractants were combined and washed with 40 ml of brine, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under vacuum, thereby obtaining a crude product. The crude product was purified by silica gel chromatography (gradient of eluents of methanol: dichloromethane: ammonia water being in a range from 4:95.6:0.4 to 6:93.5:0.4) to afford 0. 0888 g of the titled compound. 
         [0458]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0459]    ESI/MS: m/z 862 [M+H] + . 
       General Preparation Process c) 
       [0460]    Preparation of (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3O-methyl-4-C -[(n-propylamino)-methyl]-α-L- ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosy]oxy]-1-oxa-7-azacyclopentadecan-15-one. 
         [0461]    Compound 10 (0.5 g, 0.6694 mmol) prepared according to example 83 and n-propylamine (0.5 g, 25 nlmmol) were dissolved under vibration in isopropanol (10 ml) at 50° C., and the resulting mixture was stirred at the same temperature for 72 h. Reaction progress was monitored by TLC. After the reaction was completed, the resulting reaction mixture was concentrated, and the residue was added into saturated sodium bicarbonate solution (50 ml) and dichloromethane (80 ml). The mixture was vibrated uniformly, and stood to be stratified. The organic phase dichloromethane was washed with water (3×50 ml). The organic phases were combined, dried over MgSO 4 , and concentrated under vacuum to dryness. The resulting substance was dissolved in dichloromethane, and applied on GF254 silica gel. Thin layer chromatography separation was performed with an eluent of 4/1 cyclohexane/diethylamine or 4/1/0.01 dichloromethane/methanol/ammonia water. The chromatographic band corresponding to the desired product was scraped off and further purified by silica gel chromatography eluted with a mixture of dichloromethane/methanol/ammonia in a ratio of 4/1/0.01. The mobile phase was concentrated at 50° C. under vacuum and dried, thereby obtaining 0.16 g of the titled compound as a pure amine. 
         [0462]    TLC Rf=0.47(dichloromethane: methanol=5:1). 
         [0463]    ESI/MS: m/z 848[M+H] + . 
         [0464]    Compounds of examples 85-187 each have a structure shown by the following general formula 1, in which substituent group R is as shown by Table 2. Compounds of examples 85-187 are prepared according to the general preparation process (a), general preparation process (b) and general preparation process (c) of the above example 84.Specific reaction time for preparation of each of compounds of examples 85 to 187 is shown in Table 2. In Table 2, structures, yields and mass spec are data of the final compounds. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0465]    In examples 84 to 187, R is a group shown by Table 2, and nitrogen or sulfur in R is directly attached to methylene of R 3 . R’ in each of examples 84 to 187 is n-propyl. 
         [0000]    
       
         
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                 Mass 
               
               
                   
                 Compound 
                   
                 Preparation 
                 Reaction  
                 Yield 
                 spec 
               
               
                 Examples 
                 No. 
                 R 
                 process 
                 time, h 
                 % 
                 M + H 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                  84 (general 
                 syzx-217 
                 cyclopropylamino 
                 general 
                 72 
                 76 
                 846 
               
               
                 preparation 
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process (a)) 
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  84 (general 
                 syzx-102 
                 n-butylamino 
                 general 
                 72 
                 20 
                 862 
               
               
                 preparation 
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process (b)) 
                   
                   
                 process (b) 
                   
                   
                   
               
               
                  84(general 
                 syzx-101 
                 n-propylamino 
                 general 
                 72 
                 32 
                 848 
               
               
                 preparation 
                   
                   
                 preparation 
                   
                   
                   
               
               
                 process (c)) 
                   
                   
                 process (c) 
                   
                   
                   
               
               
                  85 
                 syzx-103 
                 diethylamino 
                 general 
                 72 
                 60 
                 862 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  86 
                 syzx-104 
                 phenylamino 
                 general 
                 72 
                 58 
                 882 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  87 
                 syzx-105 
                 morpholinyl 
                 general 
                 72 
                 42 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  88 
                 syzx-106 
                 (5-amino-1,3,3-trimethyl-  
                 general 
                 72 
                 59 
                 959 
               
               
                   
                   
                 cyclohexylmethyl)-amino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  89 
                 syzx-107 
                 piperonylamino 
                 general 
                 72 
                 58 
                 926 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  90 
                 syzx-108 
                 4-fluorobenzylamino 
                 general 
                 72 
                 32 
                 914 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                  91 
                 syzx-109 
                 1,2,3-triazolyl 
                 general 
                 72 
                 40 
                 858 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  92 
                 syzx-110 
                 ethylamino 
                 general 
                 72 
                 33 
                 834 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  93 
                 syzx-111 
                 isopropylamino 
                 general 
                 72 
                 35 
                 848 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  94 
                 syzx-112 
                 isobutylamino 
                 general 
                 72 
                 56 
                 862 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  95 
                 syzx-113 
                 3-chlorophenylamino 
                 general 
                 72 
                 51 
                 914 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process a 
                   
                   
                   
               
               
                  96 
                 syzx-114 
                 tert-butylamino 
                 general 
                 72 
                 55 
                 862 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  97 
                 syzx-115 
                 n-hexylamino 
                 general 
                 72 
                 60 
                 890 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  98 
                 syzx-116 
                 4-trifluoromethylbenzylamino 
                 general 
                 72 
                 70 
                 964 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                  99 
                 syzx-117 
                 cyclopropyl-methylamino 
                 general 
                 72 
                 55 
                 860 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 100 
                 syzx-118 
                 4-methoxy-benzylamino 
                 general 
                 72 
                 51 
                 926 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 101 
                 syzx-119 
                 4-nitro-benzyl-amino 
                 general 
                 72 
                 52 
                 941 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 102 
                 syzx-120 
                 4-chloro-benzyl-amino 
                 general 
                 72 
                 60 
                 930 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 103 
                 syzx-121 
                 3-pyridinylmethylamino 
                 general 
                 72 
                 33 
                 897 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 104 
                 syzx-122 
                 3-ethoxyl-propyl-amino 
                 general 
                 72 
                 36 
                 892 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 105 
                 syzx-125 
                 2-methoxyethyl-amino 
                 general 
                 72 
                 45 
                 864 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 106 
                 syzx-126 
                 (N-methyl-2-hydroxy-ethyl)-amino 
                 general 
                 72 
                 50 
                 864 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 107 
                 syzx-127 
                 3-methoxy-benzyl-amino 
                 general 
                 72 
                 24 
                 926 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 108 
                 syzx-130 
                 cyclopentyl-amino 
                 general 
                 72 
                 36 
                 874 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 109 
                 syzx-131 
                 2,4-difluorobenzyl-amino 
                 general 
                 72 
                 44 
                 932 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process(c) 
                   
                   
                   
               
               
                 110 
                 syzx-132 
                 6-chloro-pyridazin-3-yl-amino 
                 general 
                 72 
                 58 
                 918 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 111 
                 syzx-133 
                 4-hydroxy-butylamino 
                 general 
                 72 
                 23 
                 878 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 112 
                 syzx-134 
                 1-methyl-3-phenyl-propylamino 
                 general 
                 72 
                 26 
                 938 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 113 
                 syzx-135 
                 3-methoxy-benzylamino 
                 general 
                 72 
                 55 
                 926 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 114 
                 syzx-136 
                 piperazinyl 
                 general 
                 72 
                 56 
                 875 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 115 
                 syzx-137 
                 trifluoroacetylamino 
                 general 
                 72 
                 20 
                 902 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 116 
                 syzx-138 
                 2-chloro-pyridin-4-yl-amino 
                 general 
                 72 
                 23 
                 917 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 117 
                 syzx-139 
                 4-formylbenzylamino 
                 general 
                 72 
                 45 
                 940 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 118 
                 syzx-140 
                 propargyl-amino 
                 general 
                 72 
                 56 
                 844 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process(a) 
                   
                   
                   
               
               
                 119 
                 syzx-141 
                 1-butyrate 2-amino 
                 general 
                 72 
                 60 
                 892 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 120 
                 syzx-142 
                 1-butyrate 4-amino 
                 general 
                 72 
                 50 
                 892 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 121 
                 syzx-143 
                 diglycol-amino 
                 general 
                 72 
                 45 
                 894 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 122 
                 syzx-145 
                 2-hydroxy-1-hydroxyethyl- 
                 general 
                 72 
                 56 
                 880 
               
               
                   
                   
                 ethylamino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 123 
                 syzx-146 
                 3-hydroxy-propylamino 
                 general 
                 72 
                 57 
                 864 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 124 
                 syzx-147 
                 n-pentyl-amino 
                 general 
                 72 
                 23 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 125 
                 syzx-148 
                 morpholin-4-yl-amino 
                 general 
                 72 
                 60 
                 891 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 126 
                 syzx-150 
                 3-amino-butyrate 
                 general 
                 72 
                 66 
                 892 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 127 
                 syzx-151 
                 1-hydroxymethyl-propylamino 
                 general 
                 72 
                 77 
                 878 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 128 
                 syzx-153 
                 ethyl sulfate-amino 
                 general 
                 72 
                 25 
                 930 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process 1 
                   
                   
                   
               
               
                 129 
                 syzx-154 
                 3,4-difluorophenylmethylamino 
                 general 
                 72 
                 28 
                 932 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 130 
                 syzx-155 
                 3,5-difluorophenylmethylamino 
                 general 
                 72 
                 50 
                 932 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 131 
                 syzx-158 
                 2-methoxyethylamino 
                 general 
                 72 
                 36 
                 864 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process a 
                   
                   
                   
               
               
                 132 
                 syzx-159 
                 1-methyl-4- 
                 general 
                 72 
                 37 
                 947 
               
               
                   
                   
                 diethylaminobutylamino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 133 
                 Syzx-161 
                 4-sulphonylamino- 
                 general 
                 72 
                 5 
                 989 
               
               
                   
                   
                 phenylethylamino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 134 
                 syzx-162 
                 1-methyl-but-1-ene-3-yne-amino 
                 general 
                 72 
                 25 
                 870 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 135 
                 syzx-163 
                 1-methyl-butyl-amino 
                 general 
                 72 
                 27 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 136 
                 syzx-164 
                 (2-pyridin-4-yl-ethylamino 
                 general 
                 72 
                 28 
                 911 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 137 
                 syzx-165 
                 (5-methyl-pyrazin-2-  
                 general 
                 72 
                 29 
                 912 
               
               
                   
                   
                 yl-methyl)-amino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 138 
                 syzx-167 
                 cyclohexyl-methyl-amino 
                 general 
                 72 
                 33 
                 902 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 139 
                 syzx-168 
                 2-fluoro-phenyl-amino 
                 general 
                 72 
                 63 
                 900 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 140 
                 syzx-169 
                 3-morpholinyl-propyl-amino 
                 general 
                 72 
                 55 
                 933 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 141 
                 syzx-170 
                 2-chloro-phenylmethyl-amino 
                 general 
                 72 
                 38 
                 947 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 142 
                 syzx-171 
                 2-furyl-methyl-amino 
                 general 
                 72 
                 39 
                 902 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 143 
                 syzx-172 
                 3-aminobenzyl-amino 
                 general 
                 72 
                 50 
                 930 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 144 
                 syzx-173 
                 phenylhydrazono 
                 general 
                 72 
                 23 
                 897 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 145 
                 syzx-174 
                 2-(1H-indol-3-yl)-ethylamino 
                 general 
                 72 
                 46 
                 949 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 146 
                 syzx-175 
                 3-chloro-propyl-amino 
                 general 
                 72 
                 44 
                 882 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
                   
                   
                   
               
               
                 147 
                 syzx-176 
                 3,5-dimethoxyphenyl-amino 
                 general 
                 72 
                 43 
                 942 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 148 
                 syzx-178 
                 5-methyl-furan-2-yl-amino 
                 general 
                 72 
                 50 
                 886 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 149 
                 syzx-181 
                 4-fluoro-phenylhydrazono 
                 general 
                 72 
                 30 
                 915 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 150 
                 syzx-182 
                 benzyloxy-amino 
                 general 
                 72 
                 21 
                 912 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 151 
                 syzx-183 
                 p-methoxyphenyl-amino 
                 general 
                 72 
                 25 
                 912 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 152 
                 syzx-184 
                 3,4-dimethylphenyl-amino 
                 general 
                 72 
                 20 
                 910 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 153 
                 syzx-187 
                 diethyl-methyl-amino 
                 general 
                 72 
                 28 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 154 
                 syzx-188 
                 3-morpholinyl-propyl-amino  
                 general 
                 72 
                 29 
                 933 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 155 
                 syzx-190 
                 2-pyrrolyl-ethyl-amino 
                 general 
                 72 
                 32 
                 903 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (b) 
                   
                   
                   
               
               
                 156 
                 syzx-191 
                 2-pyridin-4-yl-ethylamino 
                 general 
                 72 
                 33 
                 911 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 157 
                 syzx-192 
                 2-fluorobenzyl-amino 
                 general 
                 72 
                 36 
                 914 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 158 
                 syzx-193 
                 2-piperidin-4-yl-methyl-amino 
                 general 
                 72 
                 11 
                 903 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 159 
                 syzx-197 
                 2-methyl-4-chloro-phenyl-amino 
                 general 
                 72 
                 23 
                 930 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 160 
                 syzx-198 
                 N-methyl-butyl-amino 
                 general 
                 72 
                 12 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 161 
                 Syzx-202 
                 4,6-dichloro-pyrimidin-2-yl-amino 
                 general 
                 72 
                 42 
                 952 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 162 
                 Syzx-203 
                 cycloheptylamino 
                 general 
                 72 
                 59 
                 902 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 163 
                 Syzx-204 
                 morpholinyl 
                 general 
                 72 
                 58 
                 876 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 164 
                 Syzx-205 
                 4,4-dimethoxy-butylamino 
                 general 
                 72 
                 32 
                 922 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 165 
                 Syzx-206 
                 piperidinyl-1-amino 
                 general 
                 72 
                 40 
                 889 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 166 
                 Syzx-208 
                 6-chloro-pyridin-3-yl-amino 
                 general 
                 72 
                 35 
                 917 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 167 
                 Syzx-209 
                 tetrahydropyrrolyl 
                 general 
                 72 
                 56 
                 860 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 168 
                 Syzx-210 
                 5-hydrosulphonyl-1H-[1,2,4] 
                 general 
                 72 
                 51 
                 905 
               
               
                   
                   
                 triazol-3-yl-amino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 169 
                 Syzx-211 
                 5-chloropyridinyl-2-amino 
                 general 
                 72 
                 55 
                 917 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 170 
                 Syzx-213 
                 N-ethylmethylamino 
                 general 
                 72 
                 70 
                 848 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 171 
                 Syzx-214 
                 diallylamino 
                 general 
                 72 
                 55 
                 886 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 172 
                 Syzx-215 
                 2,2,2-trifluoroacetamido 
                 general 
                 72 
                 51 
                 902 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 173 
                 Syzx-218 
                 2-chloropyridinyl-3-amino 
                 general 
                 72 
                 33 
                 917 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 174 
                 Syzx-219 
                 benzamido 
                 general 
                 72 
                 36 
                 910 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 175 
                 Syzx-222 
                 4,6-dimethoxypyrimidinyl- 
                 general 
                 72 
                 45 
                 944 
               
               
                   
                   
                 2-amino 
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 176 
                 Syzx-223 
                 3-bromophenylamino 
                 general 
                 72 
                 50 
                 960 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 177 
                 Syzx-226 
                 5-fluoro-2-nitrophenylamino 
                 general 
                 72 
                 12 
                 945 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 178 
                 Syzx-227 
                 p-iodophenylamino 
                 general 
                 72 
                 9 
                 1008 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 179 
                 Syzx-228 
                 2,4-dinitrophenylamino 
                 general 
                 72 
                 5 
                 972 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 180 
                 Syzx-229 
                 2,4-dimethylphenylamino 
                 general 
                 72 
                 6 
                 910 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 181 
                 Syzx-230 
                 3,5-di(trifluromethyl) 
                 general 
                 72 
                 8 
                 1018 
               
               
                   
                   
                 phenylamino 
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 182 
                 Syzx-231 
                 2,4-dichlorophenylamino 
                 general 
                 72 
                 10 
                 950 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 183 
                 Syzx-234 
                 5-chloro o-methylphenylamino 
                 general 
                 72 
                 6 
                 930 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 184 
                 Syzx-235 
                 allopurinol 
                 general 
                 72 
                 5 
                 925 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 185 
                 Syzx-237 
                 2,6-dichloropyrimidinyl-4-amino  
                 general 
                 72 
                 10 
                 953 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 186 
                 Syzx-238 
                 2-methylimidazolyl 
                 general 
                 72 
                 11 
                 871 
               
               
                   
                   
                   
                 preparation  
                   
                   
                   
               
               
                   
                   
                   
                 process (a) 
                   
                   
                   
               
               
                 187 
                 Syzx-239 
                 N-methyl-2-hydroxyethylamino 
                 general 
                 72 
                 26 
                 864 
               
               
                   
                   
                   
                 preparation 
                   
                   
                   
               
               
                   
                   
                   
                 process (c) 
               
               
                   
               
             
          
         
       
     
         [0466]    Although the present disclosure is described based on specific examples, certain changes and equivalents are obviously understandable for a person skilled in the art, which fall within the scope of the present disclosure. 
         [0467]    Table 3 shows structural formulas of some compounds in Table 1 and Table 2. 
         [0000]    
       
         
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                   
                 Compound 
                   
                   
               
               
                 Example 
                 No. 
                 Name of amine 
                 Structural formula of the compound 
               
               
                   
               
             
             
               
                 5 (general preparation process 3) 
                 syzx-1 
                 n-propylamine 
                                           
              1 
               
               
                   
               
               
                 5 (general preparation process 2) 
                 syzx-2 
                 n-butylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  6 
                 syzx-3 
                 diethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  8 
                 syzx-5 
                 morpholine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 5 (general preparation process 1) 
                 syzx-6 
                 cyclopropylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 12 
                 syzx-10 
                 ethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 13 
                 syzx-11 
                 isopropylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 14 
                 syzx-12 
                 isobutylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 15 
                 syzx-14 
                 tert-butylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 16 
                 syzx-15 
                 piperidine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 17 
                 syzx-17 
                 cyclopropylmethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 23 
                 SYZX-25 
                 2-methoxyethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 26 
                 SYZX-30 
                 cyclopentylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 30 
                 SYZX-35 
                 3-methoxybenzylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 38 
                 syzx-47 
                 n-pentylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 45 
                 syzx-58 
                 2-methoxyethylamine  
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 52 
                 syzx-65 
                 2-aminomethyl-5- methylpyrazine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 53 
                 syzx-66 
                 3-methoxypropylamie 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 54 
                 syzx-67 
                 cyclohexylmethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 170  
                 Syzx-213 
                 N-ethylmethylamine 
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
         
       
     
       EXAMPLE 188 
       [0468]    in vitro tests of susceptibility of the compounds according to the present disclosure against bacterial strains commonly used in laboratories. 
         [0469]    In accordance with the Performance Standards for Antimicrobial Disk Susceptibility Tests: Approved Standard published by the US National Committee for Clinical Laboratory Standards, the antibactetial activities of compounds prepared according to examples 5 to 187 were tested. The MICs (minimum inhibitory concentration) of the medicaments prepared according to the examples on the following bacterial strains were measured through mini broth dilution technique. 
       1. Bacterial Strains 
       [0470]      Staphylococcus aureus  CVCC26003,  Streptococcus equines  CVCC556.  Actinobacillus pleuropneumoniae  CVCC262,  Haemophilus parasuis , and  Pasteurella multocida  CVCC399, which were purchased from the Control Institute of Veterinary Bioproducts and Pharmaceuticals, China. 
       2. Test Medicaments (as Controls) 
       [0471]    Gamithromycin prepared by a process referring to that described in CN102239174A, the content thereof being 95.2%; and 
         [0472]    Tulathromycin prepared by a process referring to that described in CN1530370A, the content thereof being 96.4%. 
       3. Test Apparatus 
       [0473]    An SW-CJ-2FD model clean bench manufactured by Suzhou Anti Airtech Co., Ltd, 
         [0474]    a DNP-9272BS-III model electro-thermal incubator manufactured by Shanghai Xinmiao Medical Instruments Manufacturing Co., Ltd, 
         [0475]    a 6132 model nucleic acid analyser manufactured by Eppendorf Germany, 
         [0476]    ABC-265 model double-range electronic scales manufactured by METTLER TOLEDO, 
         [0477]    MBA of batch No. 20120921 manufactured by Qingdao Hope Bio-Technology Co., Ltd, 
         [0478]    MHB of batch No. 20120229 manufactured by Qingdao Hope Bio-Technology Co., Ltd, 
         [0479]    new-born calf serum of batch No. 20120824 manufactured by Wei kesheng Biotech Co., Ltd, 
         [0480]    plastic culture dishes manufactured by Yangz ou Guanghua Medical Instrument Factory, 
         [0481]    a 96-channel pipetting workstation manufactured by METTLER TOLEDO, and 
         [0482]    a single-channel pipettor and a multi-channel pipettor manufactured by Eppendorf Germany. 
       4. Test Process 
       [0483]    4.1 Preparation of Culture Medium 
         [0484]    4.1.1 Culture Medium for  Staphylococcus aureus  CVCC26003 
         [0485]    Liquid culture medium: CAMHB. To MHB (prepared according to the specification of the final product) were added CaCl 2  and MgCl 2 , so that a final concentration of Ca 2+  in the culture medium was 20 mg/L and that of Mg 2+  therein was 10 mg/L. 
         [0486]    Solid culture medium: NINA prepared according to the specification of the final product. 
         [0487]    4.1.2 Culture Media for the Rest Four Bacterial Strains. 
         [0488]    Liquid culture medium: CAMHB with 10% calf serum and 0.005% NAD+. 
         [0489]    Solid culture medium: MHA with 10% calf serum and 0.005% NAD+. 4.2Strain Revival 
         [0490]    The strains were taken out of a regrigerator at −20° C. to be revived, and were spreaded by streaking on the solid culture medium with an inoculating loop. The inoculated culture medium was cultured at 35° C. in a constant temperature incubator for 20 h. Monoclonal antibodies were selected from a well-grown culture plate and streaked on the solid culture medium. The inoculated culture medium was cultured at 35° C. in the constant temperature incubator for 20 h. 
         [0491]    4.3 Dilution of the Compounds 
         [0492]    The compounds of examples 5 to 80 and the compounds of examples 84 to 187 each were prepared with 100% DMSO into a solution having a concentration of 8.8 mg/mL. A 96-well plate was used, and 100 μl of DMSO was added into each of wells 2 to 11, and 200 μl of ready-prepared medicament solution was added into the 1 st  well, 100 μl of the medicament solution was extracted from the 1 st  well and added into the 2 nd  well. Double dilution was performed until the 11 th  well, thereby forming 11 gradients. In this case, compound of parent plate was prepared. 3 μl of double diluted medicament solution was extracted with a 12-channel pipettor and added into wells 1-11 of a new disposable 96-well culture plate. The 12 th  well thereof is a controll well. For each medicament, there are two adjacent rows which are parallel. The transferred compound plate was reserved for later use. 
         [0493]    4.4 Preparation of Bacterial Liquid 
         [0494]    Representative bacterial colony was selected from the plate prepared in the above section 4.2 and added into normal saline, an OD 600  value being adjusted to a range of 0.14-0.15. The dilution ratio was recorded, and the bacterial liquid for the tests was diluted according to the recorded dilution ratio. Subsequently, the bacterial suspension and the liquid culture medium were diluted in the proportion of 1:200. The diluted solution was reserved for later use. 
         [0495]    4.5 Test Operations 
         [0496]    The medicaments and bacterial liquid were added into the compound plates from section 4.3, two rows for each medicament, and one plate for one bacterium. The test results are as shown in Table 5. The MICs of partial compounds failed to be determined in one test, thus further tests were performed under new diluted concentration, so as to further determine the MICs of the compounds. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Schematic diagram of additives in the 96-well plate 
               
             
          
           
               
                 cmd 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
                 7 
                 8 
                 9 
                 10 
                 11 
                 12 
               
               
                   
               
               
                 A 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▪ 
               
               
                 B 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▪ 
               
               
                 C 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▪ 
               
               
                 D 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▪ 
               
               
                 E 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▴ 
               
               
                 F 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▴ 
               
               
                 G 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▴ 
               
               
                 H 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ∘ 
                 ▴ 
               
               
                   
               
               
                 ∘represents 3 μl compound + 100 μl bacterial liquid; 
               
               
                 ▪represents positive control, the well contains 100 μl bacterial liquid; 
               
               
                 ▴represents negative control, the well contains 100 μl culture medium. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 MIC values (ug/mi) of the compounds 
               
             
          
           
               
                   
                   
                 
                   Actinobacillus 
                 
                 
                   Staphylococcus 
                 
                 
                   Pasteurella 
                 
                 
                   Streptococcus 
                 
                   
               
               
                   
                   
                 
                   pleuropneumoniae 
                 
                 
                   aureus 
                 
                 
                   multocida 
                 
                 
                   equines 
                 
                 
                   Haemophilus 
                 
               
               
                 Example 
                 Compound No. 
                 CVCC262 
                 CVCC26003 
                 CVCC399 
                 CVCC556 
                 
                   parasuis 
                 
               
               
                   
               
             
          
           
               
                 Comparison 
                 Gamithromycin 
                 0.25 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
               
               
                 example 1 
                   
                 0.25 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
               
               
                 Comparison 
                 Tulathromycin 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                 example 2 
                   
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                  5 general 
                 syzx-6 
                 0.125 
                 0.125 
                 0.125 
                 0.125 
                 0.125 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process 1 
                   
                   
                   
                   
                   
                   
               
               
                  5 general 
                 syzx-1 
                 0.125 
                 0.125 
                 1 
                 0.125 
                 0.125 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process 3 
                   
                   
                   
                   
                   
                   
               
               
                  5 general 
                 syzx-2 
                 1 
                 4 
                 2 
                 2 
                 2 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process 2 
                   
                   
                   
                   
                   
                   
               
               
                  6 
                 syzx-3 
                 1 
                 0.5 
                 0.125 
                 0.125 
                 0.125 
               
               
                  7 
                 syzx-4 
                 32 
                 1 
                 1 
                 ≦0.25 
                 0.5 
               
               
                  8 
                 syzx-5 
                 16 
                 0.5 
                 0.5 
                 ≦0.25 
                 0.5 
               
               
                  9 
                 syzx-7 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  10 
                 syzx-8 
                 0.5 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  11 
                 syzx-9 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  12 
                 syzx-10 
                 0.5 
                 0.5 
                 ≦0.25 
                 0.5 
                 1 
               
               
                  13 
                 syzx-11 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 0.5 
               
               
                  14 
                 syzx-12 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  15 
                 syzx-14 
                 0.5 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  16 
                 syzx-15 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  17 
                 syzx-17 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  18 
                 syzx-18 
                 16 
                 0.5 
                 2 
                 — 
                 0.5 
               
               
                  19 
                 syzx-20 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  20 
                 syzx-21 
                 32 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  21 
                 syzx-22 
                 8 
                 1 
                 0.5 
                 0.5 
                 ≦0.25 
               
               
                  22 
                 syzx-24 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
                 0.5 
               
               
                  23 
                 syzx-25 
                 16 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  24 
                 syzx-27 
                 4 
                 0.5 
                 0.5 
                 ≦0.25 
                 ≦0.25 
               
               
                  25 
                 syzx-29 
                 16 
                 1 
                 2 
                 0.5 
                 0.5 
               
               
                  26 
                 syzx-30 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 0.5 
               
               
                  27 
                 syzx-31 
                 1 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  28 
                 syzx-32 
                 0.5 
                 0.5 
                 1 
                 0.25 
                 0.25 
               
               
                  29 
                 syzx-34 
                 8 
                 8 
                 16 
                 0.5 
                 4 
               
               
                  30 
                 syzx-35 
                 0.25 
                 0.25 
                 1 
                 0.5 
                 0.25 
               
               
                  31 
                 syzx-37 
                 32 
                 0.5 
                 1 
                 ≦0.25 
                 0.5 
               
               
                  32 
                 syzx-38 
                 32 
                 1 
                 0.5 
                 0.5 
                 0.5 
               
               
                  33  
                 syzx-39 
                 0.25 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
               
               
                  34 
                 syzx-40 
                 16 
                 0.5 
                 1 
                 0.5 
                 0.5 
               
               
                  35 
                 syzx-41 
                 1 
                 2 
                 4 
                 0.5 
                 1 
               
               
                  36 
                 syzx-42 
                 1 
                 2 
                 2 
                 1 
                 1 
               
               
                  37 
                 syzx-46 
                 32 
                 1 
                 4 
                 2 
                 ≦0.25 
               
               
                  38 
                 syzx-47 
                 0.5 
                 1 
                 ≦0.25 
                 ≦0.25 
                 0.5 
               
               
                  39 
                 syzx-48 
                 16 
                 0.5 
                 1 
                 0.5 
                 ≦0.25 
               
               
                  40 
                 syzx-50 
                 0.5 
                 1 
                 1 
                 1 
                 0.5 
               
               
                  41 
                 syzx-51 
                 1 
                 0.5 
                 0.5 
                 1 
                 2 
               
               
                  42 
                 syzx-52 
                 32 
                 0.5 
                 0.5 
                 0.5 
                 ≦0.25 
               
               
                  43 
                 syzx-56 
                 0.25 
                 0.5 
                 1 
                 0.25 
                 0.5 
               
               
                  44 
                 syzx-57 
                 ≦0.25 
                 ≦0.25 
                 32 
                 4 
                 ≦0.25 
               
               
                  45 
                 syzx-58 
                 16 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  46 
                 syzx-59 
                 32 
                 1 
                 2 
                 2 
                 0.5 
               
               
                  47 
                 syzx-60 
                 8 
                 1 
                 2 
                 2 
                 1 
               
               
                  48 
                 syzx-61 
                 32 
                 ≦0.25 
                 1 
                 0.5 
                 ≦0.25 
               
               
                  49 
                 syzx-62 
                 8 
                 0.5 
                 0.5 
                 ≦0.25 
                 ≦0.25 
               
               
                  50 
                 syzx-63 
                 0.5 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  51 
                 syzx-64 
                 0.5 
                 ≦0.25 
                 0.25 
                 0.25 
                 ≦0.25 
               
               
                  52 
                 syzx-65 
                 32 
                 ≦0.25 
                 1 
                 ≦0.25 
                 ≦0.25 
               
               
                  53 
                 syzx-66 
                 8 
                 1 
                 ≦0.25 
                 0.5 
                 ≦0.25 
               
               
                  54 
                 syzx-67 
                 0.5 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  55 
                 syzx-68 
                 8 
                 ≦0.25 
                 8 
                 ≦0.25 
                 ≦0.25 
               
               
                  56 
                 syzx-69 
                 1 
                 1 
                 0.5 
                 0.5 
                 1 
               
               
                  57 
                 syzx-71 
                 16 
                 8 
                 ≦0.25 
                 ≦0.25 
                 8 
               
               
                  58 
                 syzx-72 
                 16 
                 1 
                 1 
                 ≦0.25 
                 0.25 
               
               
                  59 
                 syzx-73 
                 1 
                 1 
                 2 
                 0.5 
                 1 
               
               
                  60 
                 syzx-74 
                 1 
                 1 
                 1 
                 0.5 
                 2 
               
               
                  61 
                 syzx-75 
                 64 
                 4 
                 8 
                 4 
                 4 
               
               
                  62 
                 syzx-76 
                 64 
                 2 
                 4 
                 2 
                 1 
               
               
                  63 
                 syzx-77 
                 16 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
               
               
                  64 
                 syzx-78 
                 2 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                  65 
                 syzx-81 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  66 
                 syzx-82 
                 16 
                 0.5 
                 1 
                 ≦0.25 
                 ≦0.25 
               
               
                  67 
                 syzx-83 
                 2 
                 0.5 
                 0.25 
                 0.5 
                 0.25 
               
               
                  68 
                 syzx-84 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  69 
                 syzx-86 
                 2 
                 ≦0.25 
                 0.25 
                 ≦0.25 
                 ≦0.25 
               
               
                  70 
                 syzx-90 
                 0.5 
                 2 
                 2 
                 0.5 
                 2 
               
               
                  71 
                 syzx-91 
                 2 
                 4 
                 2 
                 1 
                 2 
               
               
                  72 
                 syzx-92 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                  73 
                 syzx-93 
                 16 
                 32 
                 64 
                 1 
                 8 
               
               
                  74 
                 syzx-94 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                  75 
                 syzx-95 
                 2 
                 2 
                 2 
                 0.5 
                 2 
               
               
                  76 
                 syzx-96 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                  77 
                 syzx-97 
                 128 
                 1 
                 4 
                 0.5 
                 1 
               
               
                  78 
                 syzx-98 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                  79 
                 syzx-99 
                 128 
                 4 
                 8 
                 2 
                 4 
               
               
                  80 
                 syzx-100 
                 1 
                 1 
                 0.5 
                 2 
                 2 
               
               
                  84 general 
                 syzx-217 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process (a) 
                   
                   
                   
                   
                   
                   
               
               
                  84 general 
                 syzx-102 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process (b) 
                   
                   
                   
                   
                   
                   
               
               
                  84 general 
                 syzx-101 
                 0.125 
                 0.125 
                 0.125 
                 0.125 
                 0.125 
               
               
                 preparation 
                   
                   
                   
                   
                   
                   
               
               
                 process (c) 
                   
                   
                   
                   
                   
                   
               
               
                  85 
                 syzx-103 
                 0,25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  86 
                 syzx-104 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  87 
                 sync-105 
                 1 
                 0.25 
                 2 
                 0.25 
                 0.5 
               
               
                  88 
                 syzx-106 
                 0.5 
                 2 
                 2 
                 0.25 
                 0.5 
               
               
                  89 
                 syzx-107 
                 0.25 
                 0.25 
                 1 
                 1 
                 0.25 
               
               
                  90 
                 syzx-108 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  91 
                 syzx-109 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  92 
                 syzx-110 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                  93 
                 syzx-111 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                  94 
                 syzx-112 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                  95 
                 syzx-113 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  96 
                 syzx-1 14 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                  97 
                 syzx-115 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                  98 
                 syzx-116 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                  99 
                 syzx-117 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 100 
                 syzx-118 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                 101 
                 syzx-119 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 102 
                 syzx-120 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 103 
                 syzx-121 
                 0.25 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
               
               
                 104 
                 syzx-122 
                 1 
                 1 
                 1 
                 0.25 
                 0.5 
               
               
                 105 
                 syzx-125 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                 106 
                 syzx-126 
                 4 
                 4 
                 2 
                 0.5 
                 4 
               
               
                 107 
                 syzx-127 
                 1 
                 4 
                 8 
                 0.25 
                 1 
               
               
                 108 
                 syzx-130 
                 0.5 
                 0.25 
                 0.5 
                 0.25 
                 8 
               
               
                 109 
                 syzx-131 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 110 
                 syzx-132 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.5 
               
               
                 111 
                 syzx-133 
                 1 
                 1 
                 2 
                 0.5 
                 0.5 
               
               
                 112 
                 syzx-134 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 113 
                 syzx-135 
                 1 
                 1 
                 2 
                 0.5 
                 0.5 
               
               
                 114 
                 syzx-136 
                 0.5 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 115 
                 syzx-137 
                 0.5 
                 0.5 
                 2 
                 1 
                 0.5 
               
               
                 116 
                 syzx-138 
                 2 
                 2 
                 8 
                 0.5 
                 2 
               
               
                 117 
                 syzx-139 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 118 
                 syzx-140 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 119 
                 syzx-141 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 120 
                 syzx-142 
                 0.25 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
               
               
                 121 
                 syzx-143 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 122 
                 syzx-145 
                 64 
                 1 
                 2 
                 0.5 
                 0.5 
               
               
                 123 
                 syzx-146 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 124 
                 syzx-147 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 125 
                 syzx-148 
                 0.5 
                 0.25 
                 1 
                 0.25 
                 0.5 
               
               
                 126 
                 syzx-150 
                 1 
                 0.5 
                 2 
                 0.25 
                 0.5 
               
               
                 127 
                 syzx-151 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 128 
                 syzx-153 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 129 
                 syzx-154 
                 0.25 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
               
               
                 130 
                 syzx-155 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 131 
                 syzx-158 
                 4 
                 2 
                 2 
                 0.25 
                 4 
               
               
                 132 
                 syzx-159 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
                 0.25 
               
               
                 133 
                 syzx-161 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 134 
                 syzx-162 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 135 
                 syzx-163 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 136 
                 syzx-164 
                 0.25 
                 0.25 
                 2 
                 0.5 
                 0.25 
               
               
                 137 
                 syzx-165 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 138 
                 syzx-167 
                 2 
                 2 
                 4 
                 0.25 
                 2 
               
               
                 139 
                 syzx-168 
                 0.25 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 140 
                 syzx-169 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 141 
                 syzx-170 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 142 
                 syzx-171 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 143 
                 syzx-172 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                 144 
                 syzx-173 
                 1 
                 2 
                 4 
                 0.25 
                 1 
               
               
                 145 
                 syzx-174 
                 4 
                 4 
                 8 
                 0.25 
                 2 
               
               
                 146 
                 syzx-175 
                 0.25 
                 0.5 
                 0.5 
                 0.5 
                 0.25 
               
               
                 147 
                 syzx-176 
                 0.25 
                 0.5 
                 2 
                 0.25 
                 0.5 
               
               
                 148 
                 syzx-178 
                 2 
                 4 
                 4 
                 0.5 
                 4 
               
               
                 149 
                 syzx-181 
                 0.5 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 150 
                 syzx-182 
                 0.5 
                 1 
                 4 
                 0.5 
                 0.5 
               
               
                 151 
                 syzx-183 
                 0.5 
                 0.25 
                 2 
                 0.25 
                 0.25 
               
               
                 152 
                 syzx-184 
                 2 
                 2 
                 4 
                 0.5 
                 2 
               
               
                 153 
                 syzx-187 
                 0.5 
                 1 
                 2 
                 0.25 
                 0.25 
               
               
                 154 
                 syzx-188 
                 0.5 
                 0.5 
                 1 
                 0.25 
                 0.5 
               
               
                 155 
                 syzx-190 
                 0.5 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 156 
                 syzx-191 
                 0.5 
                 1 
                 4 
                 0.5 
                 0.5 
               
               
                 157 
                 syzx-192 
                 4 
                 4 
                 4 
                 0.5 
                 4 
               
               
                 158 
                 syzx-193 
                 4 
                 4 
                 2 
                 0.25 
                 2 
               
               
                 159 
                 syzx-197 
                 0.5 
                 0.25 
                 1 
                 0.25 
                 0.25 
               
               
                 160 
                 syzx-198 
                 0.5 
                 1 
                 4 
                 0.5 
                 0.5 
               
               
                 161 
                 syzx-202 
                 2 
                 2 
                 2 
                 0.25 
                 4 
               
               
                 162 
                 syzx-203 
                 1 
                 1 
                 0.25 
                 1 
                 0.5 
               
               
                 163 
                 syzx-204 
                 4 
                 4 
                 4 
                 0.5 
                 4 
               
               
                 164 
                 syzx-205 
                 4 
                 4 
                 4 
                 0.5 
                 4 
               
               
                 165 
                 syzx-206 
                 0.25 
                 0.5 
                 0.5 
                 0.25 
                 0.25 
               
               
                 166 
                 syzx-208 
                 4 
                 4 
                 4 
                 0.5 
                 4 
               
               
                 167 
                 syzx-209 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                 168 
                 syzx-210 
                 0.5 
                 2 
                 4 
                 0.25 
                 0.5 
               
               
                 169 
                 syzx-211 
                 4 
                 2 
                 0 
                 0.5 
                 4 
               
               
                 170 
                 syzx-213 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
                 0.25 
               
               
                 171 
                 syzx-214 
                 2 
                 4 
                 0 
                 0.25 
                 2 
               
               
                 172 
                 syzx-215 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 173 
                 syzx-218 
                 4 
                 2 
                 0.25 
                 4 
                   
               
               
                 174 
                 syzx-219 
                 4 
                 2 
                 0 
                 0.5 
                 4 
               
               
                 175 
                 syzx-222 
                 2 
                 4 
                 8 
                 0.25 
                 2 
               
               
                 176 
                 syzx-223 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 177 
                 syzx-226 
                 4 
                 2 
                 0 
                 0.25 
                 4 
               
               
                 178 
                 syzx-227 
                 4 
                 2 
                 0 
                 0.5 
                 4 
               
               
                 179 
                 syzx-228 
                 | 
                 2 
                 2 
                 0.25 
                 1 
               
               
                 180 
                 syzx-229 
                 4 
                 4 
                 16 
                 0.25 
                 4 
               
               
                 181 
                 syzx-230 
                 2 
                 4 
                 8 
                 0.25 
                 2 
               
               
                 182 
                 syzx-231 
                 0.25 
                 0.25 
                 0.5 
                 0.25 
                 0.25 
               
               
                 183 
                 syzx-234 
                 4 
                 2 
                 0 
                 0.25 
                 4 
               
               
                 184 
                 syzx-235 
                 4 
                 2 
                 8 
                 0.5 
                 4 
               
               
                 185 
                 syzx-237 
                 4 
                 2 
                 8 
                 0.25 
                 4 
               
               
                 186 
                 syzx-238 
                 1 
                 1 
                 4 
                 0.25 
                 1 
               
               
                 187 
                 syzx-239 
                 4 
                 4 
                 0 
                 0.25 
                 2 
               
               
                   
               
             
          
         
       
     
         [0497]    The in vivo antibacterial activity was measured by conventional animal experiment process well known to the person skilled in the art, and the test animals were BALB/c mice. 
         [0498]    Test materials: standard strain of  Streptococcus pneumoniae , under Accession Numbe CMCC 31203, purchased from the National Center for Medical Culture Collections; and Tulathromycin prepared by a process referring to that described in CN1530370A. 
         [0499]    Test medicaments: compounds (syzx-1, syzx-2, syzx-6) prepared according to the three general preparation processes of example 5, and compounds prepared in example 6 (syzx-3), example 8 (syzx-5), example 12 (syzx-10), example 13 (syzx-11), example 14 (syzx-12), example 15 (syzx-14), example 16 (syzx-15), example 17 (syzx-17), example 18 (syzx-101 prepared according to the general preparation process (c)), example 26 (syzx-30), example 30 (syzx-35), example 38 (syzx-47), example 45 (syzx-58), example 52 (syzx-65), example 53 (syzx-66), example 54 (syzx-67), and example 170 (syzx-213). In the meantime, Tulathromycin was used for comparison. The compounds each were dissolved in absolute ethyl alcohol. The mixture was supplemented until the volume reached a required level, and sufficiently mixed to afford solution with a concentration of 1 mg/mL. 
       Test Process 
       [0500]    Mice each weighed in a range of 18-20 g were selected from 350 mice of 5 to 6 weeks and divided into different cages, with 10 mice in each cage. The mice were breeded for 72 h, and entered into tests if observations turned out normal. Before the tests started,  Streptococcus pneumoniae  was cultured in a blood plate for 24 h, and then added into a sterility broth containing serum for shaking culture (120 r/min) at 37° C., for 20 h, so that an enriched culture can be conducted. Viable count was performed. The bacteria were diluted to 5×1.0 8  cfu/mL, with sterilized saline water. The mice each were infected with 0.5 ml of the bacterial liquid by intraperitoneal injection. The day after the infection, compounds prepared according to the above examples and the medicament for comparison were administered to the mice by subcutaneous injection via neck at a dose of 5 mg per kg of body weight for 3 consecutive days. In the meantime, control groups, such as blank control groups and medicament control groups, were arranged. The blank control groups were not administered with any medicament after being infected. The mice in the medicament control groups each were injected with Tulathromycin at a dose of 10 mg per kg of body weight after being infected. After infection and administration, the mice were observed every day, and the death count in each group was recorded until the seventh day, Table 6 shows the influence of the compounds shown in the general formula of the present disclosure on the survival rate of mice infected by  Streptococcus pneumoniae.    
       1. Test Results 
       [0501]      
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
             
             
               
                   
               
               
                 Results of in vivo antibacterial tests of certain compounds 
               
             
          
           
               
                 Test 
                 Animal 
                 Test 
                 Animal 
                 Test 
                 Animal 
               
               
                 medicament 
                 survival rate 
                 medicament 
                 survival rate 
                 medicament 
                 survival rate 
               
               
                   
               
               
                 Blank control group 
                 100% (10/10) 
                 syzx-5 
                 70% (7/10) 
                 syzx-101 
                 90% (9/10) 
               
               
                 Tulathromycin control group 
                 70% (7/10) 
                 syzx-10 
                 90% (9/10) 
                 syzx-30 
                 80% (8/10) 
               
               
                 Negative control group 
                 30% (3/10) 
                 syzx-11 
                 70% (8/10) 
                 syzx-35 
                 70% (7/10) 
               
               
                 syzx-1 
                 80% (8/10) 
                 syzx-12 
                 70% (8/10) 
                 syzx-47 
                 90% (9/10) 
               
               
                 syzx-2 
                 80% (8/10) 
                 syzx-14 
                 70% (8/10) 
                 syzx-58 
                 80% (8/10) 
               
               
                 syzx-6 
                 80% (8/10) 
                 syzx-15 
                 70% (8/10) 
                 syzx-65 
                 90% (9/10) 
               
               
                 syzx-3 
                 70% (8/10) 
                 syzx-17 
                 70% (8/10) 
                 syzx-66 
                 80% (8/10) 
               
               
                 syzx-67 
                 70% (8/10) 
                 syzx-213 
                 90% (9/10) 
               
               
                   
               
             
          
         
       
     
       2, Results 
       [0502]    As shown in Table 6, administration of the compounds shown by the formula of the present disclosure at a dose of 5 mg per kg of body weight can reduce deaths of the mice due to infection by Streptococcus pneumoniae. As compared with the control groups, the compounds of the present disclosure can significantly improve the survival rate of the infected mice, and have manifested evident in vivo antibacterial activity. 
       EXAMPLE 189 
       [0503]    acute toxicity test of compound Syzx-24. 
       1. Test Materials 
       [0504]    1.1 Test Medicaments 
         [0505]    Name of the medicaments: compound No.Syzx-24, and tulathromycin having a content of 96.4% prepared by the process referring to that described in Chinese patent CN1530370A. 
         [0506]    1.2 Test Animals 
         [0507]    Balb/c mice, each weighed 16.0-19.0 g, were selected. The mice were half male and half female. Before the tests started, the mice were fed in different cages and observed for 3 days. 12 (half male and half female) healthy and brisk mice were selected for tests. The mice were prohibited from feeding, but not water, for 14 h (from 6 pm to 8 am the next morning) before administeration. 
         [0508]    1.3 Test Articles 
         [0509]    A mice gavage device, a 1 ml disposable syringe, a 50 mL beaker and a 100 mL beaker, individual ventilated cages (IVC), ophthalmologic operating scissors, tweezers, a medical tray, 0.5% basic fuchsin dye liquor, medical rubber gloves, an analytical balance, and electronic scales. 
       2. Test Process 
       [0510]    2.1 Test Animals Grouping 
         [0511]    Three groups were arranged for the tests, each having four mice (half male and half female). The three groups were respectively tulathromycin group, Syzx-24 group, and solvent control group. The mice were marked with 0.5% basic fuchsin dye liquor. The marked parts of mice in the tulathromycin group were respectively left upper shoulders (female), left ribs (female), right upper shoulders (male) and right ribs (male). 
         [0512]    The marked parts of mice in the Syzx-24 group were respectively left hinder limbs (female), necks (female), right hinder limbs (male), and necks (male). The mice in the solvent control group were not marked. 
         [0513]    Mice in the administered group were administered at a dose of 2000 mg/kg.d-1 (it was reported that the minimum lethal dose of tulathromycin in orally intoxicated mice is higher than 2000 mg/kg.d-1). 
         [0514]    2.2 Preparation of Medicament 
         [0515]    0.2 g of sodium carboxymethylcellulose was added into 40 ml of purified water and dissolved therein under stirring at 80° C., thereby forming 0.5% sodium carboxymethylcellulose solution as solvent for preparing the medicament. The test medicament was added into the 0.5% sodium carboxymethylcellulose solution according to the dosage of administration, which gave 170 mg/ml suspension. 0.5% sodium carboxymethylcellulose solution of the same volume was added into the suspension and screened through a 100 mesh, whereby a suspension having a concentration of 85 mg/ml was prepared. 
         [0516]    2.3 Administration Process 
         [0517]    The medicaments were formulated into 85 mg/m1 suspensions and administered by gastric perfusion once at a dose of 2000 Ing/kg.d-1. In other words, the medicament was administered to each mouse at a dose of 0.47 ml per 20 g of body weight. Specific grouping and administration are shown in Table 7. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                 Grouping of test animals 
               
             
          
           
               
                   
                 Number of 
                   
               
               
                 Group 
                 animals (n) 
                 Dosage 
               
               
                   
               
               
                 Tulathromycin 
                 4 
                 85 mg/ml tulathromycin 
               
               
                 group 
                   
                 suspension, at a dose of 0.47 ml/20 g 
               
               
                   
                   
                 by gastric perfusion 
               
               
                 Syzx-24 group 
                 4 
                 85 mg/ml Syzx-24 suspension, at a 
               
               
                   
                   
                 dose of 0.47 ml/20 g by gastric 
               
               
                   
                   
                 perfusion 
               
               
                 Solvent control 
                 4 
                 0.5% sodium 
               
               
                 group 
                   
                 carboxymethylcellulose solution, at a 
               
               
                   
                   
                 dose of 0.47 ml/20 g by gastric 
               
               
                   
                   
                 perfusion 
               
               
                   
               
             
          
         
       
     
         [0518]    After administration of the medicaments, toxic symptons and deaths of the animals within 6 h after administration were observed and recorded. The animals were continuously observed for 30 min after administration, and observed once from 1 h to 4 h after administration. Subsequently, the animals were observed once a day until recovery. Toxic symptoms and deaths were recorded, and dead animals were dissected without delay, so that organs, such as heart, liver, spleen, lungs, kidneys, stomach and intestines, can be observed. 
         [0519]    3. Test Results and Analysis 
         [0520]    3.1 Death rates after 6 h upon infection were compared. Table 8 shows the death status and death rates of the groups. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                 Results of deaths of animals 
               
             
          
           
               
                   
                 Number of dead animals/total 
                   
               
               
                 Group 
                 number of animals 
                 Death rate 
               
               
                   
               
               
                 Tulathromycin group 
                 3/4 (2 female and 1 male) 
                 75%  
               
               
                 Syzx-24 group 
                 0/4 
                 0% 
               
               
                 Solvent control group 
                 0/4 
                 0% 
               
               
                   
               
             
          
         
       
     
         [0521]    Acute toxicity tests indicate that toxicities of the compounds according to the present disclosure were obviously lower than that of tulathromycin. 
       EXAMPLE 190 
       [0522]    acute toxicity of orally administered compounds of the present disclosure. 
       1. Test Materials 
       [0523]    1.1 Appliances and Materials 
         [0524]    1 ml disposable plastic sterile syringe, small operating scissors, disposable rubber gloves, a WKZ-4 model pulverizer, a mortar, a measuring cylinder, a beaker, TIANYIJA2003 electronic scales, a medical tray, carbazotic acid dye, medical rubber gloves, a mice gavage device (No. 12), sodium carboxymethylcellulose (Tianjin Kemiou Chemical Reagent Co., Ltd), and the like. 
         [0525]    1.2 Test Medicaments 
         [0526]    Compounds (syzx-, syzx-2, syzx-6) prepared through the three general preparation processes according to example 5, compound of example 6 (syzx-3), compound of example 8 (syzx-5), compound of example 12 (syzx-10), compound of example 13 (syzx-11), compound of example 14 (syzx-12), compound of example 15 (syzx-14), compound of example 16 (syzx-15), compound of example 17 (syzx-17), compound of example 45 (syzx-58), compound (syzx-101) prepared in general preparation process (c) of example 84, and compound of example 170 (syzx-213). 
         [0527]    Solvent for the medicaments: 0.2% sodium carboxymethylcellulose solution. 
         [0528]    1.3 Test Animals 
         [0529]    SPF level Konmin mice purchased from Henan Provicial Laboratory Animal Center, license number being SC) (         )2010-0002. The mice comprise half male and half female, each weighed 18-22 g. The female mice and the male mice are separated and fed in individual ventilated cages. Rearing condition of the mice include sterilized complete teed, free choice feeding and drinking, room temperature in a range of 10-24° C., and relative humidity in a range of 40-60%. 
       2. Test Process 
       [0530]    2.1 Preparation of Medicaments 
         [0531]    2.1.1 Preparation of a 0.2% sodium carboxymethylcellulose solution 0.2 g of sodium carboxymethylcellulose was dissolved in 100 ml of purified water, placed overnight for swelling, and then stirred uniformly for later use. 
         [0532]    2.1.2 The compounds of some examples were powdered using a mortar, and sifted through mesh (100-mesh) for later use. 
         [0533]    2.2 Test Process 
         [0534]    Trial tests were performed repeatedly, so that an interval range between LD 0  and LD 100  can be determined and divided into groups, thereby grouping and determining the difference between the groups. 
         [0535]    In official tests, 60 mice each weighed in a range of 18-22 g were selected for each medicament. Male mice and female mice were separated and respectively weighed. Mice of the same weight range (for example a range of 18.0-18.9 g or a range of 19.0-19.9 g) were marked and fed in the same cage. The male mice and the female mice were respectively divided into 6 groups at random based on weight, so that mice of different gender and different weight can be evenly distributed in each group, and each group included 10 mice, in which half were male and half were female. Before the mice were infected, the medicament was prepared with 0.2% sodium carboxymethylcellulose solution based on a predetermined concentration. The mice each were gavaged once at a dose of 0.2ml per 10 g of body weight. The mice were prohibited from feeding, but not from water, within 12-16 h before gavaging. The general health conditions, toxic symptoms, and the death process of the mice were minutely observed and recorded right after the gavaging. The dead mice were roughly dissected without delay, and continuously observed for 7 days. 
         [0536]    Per os LD 50  and 95% fiducial limit (FL) were calculated according to improved karber method. The calculation equations are as follows: 
         [0000]              LD   50     =       lg     -   1            [       X   m     -     i        (       ∑              p     -   0.5     )         ]                     S     x                 50       =     i          ∑     pq   n                 The 95% fiducial limit: FL= lg   1 ( lgLD   50 ±1.96× S   x50 )
 
         [0537]    In the above equations, X m —logarithmic value of the maximum dosage, 
         [0538]    i—logarithm of ratio between two adjacent dosages, 
         [0539]    p—death rate at each dosage (represented by decimals), 
         [0540]    q—survival rate at each dosage, q=−p, 
         [0541]    Σp—sum of death rates of the groups, 
         [0542]    n—number of animals in each group, 
         [0543]    P m —maximum death rate, 
         [0544]    P n —minimum death rate, 
         [0545]    S x50 —standard error of lgLD 50 . 
       3. Test Results 
       [0546]      
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                 Results of acute oral toxicity test on partial compounds of the present disclosure 
               
             
          
           
               
                   
                 LD 50   
                 95% fiducial 
                   
                 LD 50   
                 95% fiducial 
               
               
                 Compound 
                 (mg/kg) 
                 limit (mg/kg) 
                 Compound 
                 (mg/kg) 
                 limit (mg/kg) 
               
               
                   
               
               
                 syzx-1 
                 2584.8 
                 2156.3-3098.4 
                 syzx-11 
                 4196.0 
                 3535.6-4979.8 
               
               
                 syzx-2 
                 2547.8 
                 2231.2-2909.2 
                 syzx-12 
                 4313.5 
                 3753.3-4957.4 
               
               
                 syzx-6 
                 2611.7 
                 2229.0-3060.0 
                 syzx-14 
                 2589.5 
                 2099.5-3139.8 
               
               
                 syzx-3 
                 2487.1 
                 2162.2-2860.9 
                 syzx-15 
                 2662.0 
                 2243.0-3159.3 
               
               
                 syzx-5 
                 2734.4 
                 2219.4-3368.8 
                 syzx-17 
                 2673.5 
                 2322.3-3077.7 
               
               
                 syzx-10 
                 2809.6 
                 2291.0-3445.7 
                 syzx-58 
                 3549.4 
                 2990.7-4212.4 
               
               
                 syzx-213 
                 2794.8 
                 2375.7-3287.9 
                 syzx-101 
                 3760.6 
                 2334.8-3263.9 
               
               
                 Tulathromycin 
                 2379.2 
                 1608.1-2818.7 
                 Gamithromycin 
                 2165.2 
                 1793.8-2613.6 
               
               
                   
               
             
          
         
       
     
         [0547]    According to the LD 50  dosage grading stardards for acute toxicity of chemicals in the Guidelines for Acute Toxicity of Veterinary Drugs, a drug, the LD 50 , of which is in a range of 501-5000 mg/kg body weight, is assessed as low toxic. Obviously, the compounds prepared according to the present disclosure have lower toxicity. It is known to the person skilled in the art that the higher the value of LD 50 , the lower the toxicity. 
         [0548]    The above embodiments are described only for better understanding, rather than restricting, the present disclosure. Various modifications and variants to the present disclosure may be made by anyone skilled in the art, without departing from the scope and spirit of the present disclosure. The scope of the present disclosure should still be subjected to the scope defined in the claims.