Abstract:
A method and apparatus for cooling a human being utilizes skin temperature feedback to control the amount of cooling. When the measured skin temperature reaches a preset high temperature, the human being is cooled until the measured skin temperature reaches a preset low temperature, and then cooling of the human being stops. In one embodiment, the preset high temperature is about 35 degrees Centigrade and the preset low temperature is about 33 degrees Centigrade. Cooling of the human being resumes whenever the preset high temperature is reached and pauses whenever the preset low temperature is reached to thereby provide intermittent cooling to the human being. The invention is also applicable to heating a human being.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims the benefit of priority of U.S. provisional patent application Ser. No. 60/538,140 filed Jan. 22, 2004, which is hereby incorporated by reference. 
    
    
     STATEMENT OF GOVERNMENT INTEREST 
     The invention described herein may be manufactured and used by or for the Government of the United States of America for government purposes without the payment of any royalties therefor. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention relates in general to methods and devices for regulating body temperature in humans and in particular to methods and devices for regulating body temperature in humans using skin temperature feedback. 
     Some closely related literature includes, in ascending chronological order: (1) Shitzer, A., Chato, J. C., and Hertig, B. A. Thermal protective garment using independent regional control of coolant temperature. Aerospace Med. 1: 49-59, 1973. (2) Veicsteinas, A, Ferretti, G, and Rennie, D W. Superficial shell insulation in resting and exercising men in cold water. J. Appl. Physiol. 52: 1557-1564, 1982. (3) Sawka, M N, Gonzalez, R R, Drolet, L L, and Pandolf, K B. Heat exchange during upper and lower body exercise.  J. Appl. Physiol.  57: 1050-1054, 1984. (4) Johnson, J M, Brenglemann, G L, Hales, J R S, Vanhoutte, P M, and Wenger, C B. Regulation of the cutaneous circulation. Federation Proc. 45: 2841-2850, 1986. (5) Speckman, K L, Allan, A E, Sawka, M N, Young, A J, Muza, S R, and Pandolf, K B. Perspectives in microclimate cooling involving protective clothing in hot environments. International Journal of Industrial Ergonomics. 3: 121-147, 1988. (6) Pergola, P E, Kellogg, D L, Johnson, J M, and Kosiba, W. Reflex control of active cutaneous vasodilation by skin temperature in humans. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1979-H1984, 1994. (7) Constable, S. H., Bishop, P. A., Nunneley, S. A., and Chen, T. Intermittent microclimate cooling during rest increases work capacity and reduces heat stress. Ergonomics. 37(2): 277-285, 1994. (8) Bomalaski, S. H., Chen, Y. T., and Constable, S. H. Continuous and intermittent personal microclimate cooling strategies. Aviat. Space Environ. Med. 66(8): 745-750, 1995. (9) Pergola, P E, Johnson, J M, Kellogg, D L, and Kosiba, W. Control of skin blood flow by whole body and local skin cooling in exercising humans. Am. J. Physiol. 270 (Heart Circ. Physiol. 35): H208-H215, 1996. (10) Xu, X., Hexamer, M., and Wemer, J. Multi-loop control of liquid cooling garment systems. Ergonomics. 42(2): 282-298, 1999. (11) Nyberg, K. L., Diller, K. R., and Wissler, E. H. Model of human/liquid cooling garment interaction for space suit automatic thermal control. J. Biomechanical Engineering. 123: 114-120, 2001. (12) Cheuvront, S. N., Kolka, M. A., Cadarette, B. S., Montain, S. J., and Sawka, M. N. Efficacy of intermittent, regional microclimate cooling. J. Appl. Physiol. 94: 1841-1848, 2003. (13) Thomley, L. J., Cheung, S. S., and Sleivert, G. G. Responsiveness of thermal sensors to nonuniform thermal environments and exercise. Aviat. Space Environ. Med. 74: 1135-1141, 2003. (14) Xu, X., Berglund, L. G., Cheuvront, S. N., Endrusick, T. L., and Kolka, M. A. Model of human thermoregulation for intermittent regional cooling. Aviat. Space Environ. Med. 75: 1065-1069, 2004. 
     Many occupations (e.g., firefighters, soldiers, astronauts, explosive ordnance, toxic waste clean-up) require workers to wear personal protective equipment (PPE) with characteristic high insulation (clo) and low moisture permeability (i m ) properties. These conditions impose uncompensable heat stress (required evaporative cooling exceeds evaporative cooling capacity of environment) that results in rapid heat storage and a reduction in work capabilities. Specifically, physical and cognitive performance is severely compromised and heat strain becomes overwhelming in a relatively short period. 
     Present-day microclimate cooling (MCC) systems are designed to remove heat from the skin using ice-packet vests, cooled air, or by circulating cooled liquid in tubes. Each of these methods is effective in reducing heat strain and extending work performance. For most military, space, and firefighting applications, liquid-cooled systems have several advantages over other MCC approaches, including reduced logistical requirements and sustainable high cooling capacities. 
     Engineering approaches for developing liquid MCC systems have focused on enhancing MCC efficacy by reducing coolant temperatures or increasing coolant flow. However, these engineering approaches increase MCC power (battery) requirements. Ironically they may also reduce heat transfer potential in certain situations. Skin cooling produces cutaneous vascular constriction that decreases convective heat transfer from the body core to the periphery. Superficial shell insulation (skin and subcutaneous fat) approaches near maximal values at skin temperatures of 30° C., with the onset of vasoconstriction occurring at skin temperatures of 32-33° C. Thus, the heat loss advantage obtained by widening the core-to-skin temperature gradient with constant cooling is progressively reduced by increased superficial shell insulation as skin temperature drops below 32° C. 
     A primary object of the present invention is to reduce the amount of power required for body cooling and/or heating. This and other objects of the invention are achieved by using skin temperature feedback to control the cooling or heating of the body. In one embodiment, the skin temperature is maintained between a high temperature of about 35 degrees Centigrade and a low temperature of about 33 degrees Centigrade. 
     Further objects, features and advantages of the invention will become apparent from the following detailed description taken in conjunction with the accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a graph of body core temperature (rectal temperature, T re ) versus time for six cooling paradigms. 
         FIG. 2  is a graph of the change in heart rate versus skin temperature. 
         FIGS. 3A-3C  are bar graphs of thermal comfort and thermal sensation for three cooling paradigms. 
         FIG. 4  is a comparison of three cooling paradigms showing mean and standard deviation values for four parameters. 
         FIG. 5A  is a schematic showing cooling of a human being using skin temperature feedback. 
         FIG. 5B  is a schematic showing heating of a human being using skin temperature feedback. 
         FIG. 6  is a schematic drawing of a body cooling apparatus. 
         FIG. 7  is a schematic drawing of a portion of a body cooling apparatus. 
     
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     The inventors were the first to compare the effects of systematic intermittent cooling (IC) to constant cooling (CC) of the skin for improving MCC effectiveness during work in protective clothing. They discovered that the heat flux benefits from periodically (intermittently) applying cooling to warm-vasodilated skin offset the potential for vasoconstriction that occurs with continuous skin cooling. The inventors observed that when skin temperature was maintained between about 33 and 35 degrees Centigrade in IC, thermoregulatory and cardiovascular strain was similar to CC despite less total cooling time with IC. That is to say, this is the temperature range that optimized heat flux by minimizing vasoconstriction, without undue cardiovascular strain, and with an added potential of reducing MCC power (battery) requirements as a consequence of reducing the total required cooling time. The inventors hypothesized that the most efficient MCC system would provide automated cooling on demand using an approximate skin temperature range (33 to 35 degrees Centigrade) as feedback control for perfusion (begin cooling when skin temperature reaches 35 degrees Centigrade) and withdrawal (stop cooling when skin temperature reaches 33 degrees Centigrade). 
       FIG. 1  illustrates that IC reduces thermoregulatory strain (rectal temperature) similarly to CC regardless of the systematic IC paradigm used (IRC 1 - 4 ). When no cooling is provided (NC) rectal temperature rises significantly above all cooling paradigms after 50 minutes of work. From: Cheuvront, S. N., Kolka, M. A., Cadarette, B. S., Montain, S. J., and Sawka, M. N. Efficacy of intermittent, regional microclimate cooling. J. Appl. Physiol. 94: 1841-1848, 2003. 
       FIG. 2  illustrates that cardiovascular strain is similar when MCC maintains skin temperature between 32 and 35 degrees Centigrade. When skin temperature exceeds 35 degrees Centigrade, a severe penalty results. The relationship between heart rate change and mean skin temperature is curvilinear [y=3668+−225.8 (T sk )+3.499 (T sk ) 2 ]. Shaded area represents temperature band for optimal heat transfer. From: Cheuvront, S. N., Kolka, M. A., Cadarette, B. S., Montain, S. J., and Sawka, M. N. Efficacy of intermittent, regional microclimate cooling. J. Appl. Physiol. 94: 1841-1848, 2003. 
     An embodiment of a skin temperature feedback MCC system was built and the energy savings hypothesis was tested. CC, IC and skin temperature feedback were compared. All three paradigms resulted in similar thermoregulatory and cardiovascular strain, as well as perceived thermal comfort. Compared with CC, IC and skin temperature feedback reduced power requirements by 25% and 46%, respectively. This reduction in power requirement is a very significant advance in the art of human body thermoregulation. 
       FIGS. 3A-3C  illustrate thermal comfort and thermal sensation for three cooling paradigms.  FIG. 3A  shows constant cooling (CC),  FIG. 3B  shows intermittent cooling (IC) and  FIG. 3C  shows intermittent cooling using skin temperature feedback (Icskin). Thermal comfort and sensation are similar among trials. From: Vemieuw, C. R., Stephenson, L. A., and Kolka, M. A., Thermal comfort and sensation in exercising soldiers wearing a microclimate cooling system individually controlled by skin temperature. In preparation for publication. 
       FIG. 4  is a comparison of three cooling paradigms (CC, IC and skin temperature feedback) showing mean and standard deviation values for change in heart rate (delta HR), change in core temperature (delta Tc), difference between core temperature and skin temperature (Tc-Tskin) and electrical power requirements. Thermoregulatory and cardiovascular strain was similar among the three paradigms. Cooling power requirements were reduced by 25% and 46% in IC and skin temperature feedback, respectively, compared with CC. From: Stephenson, L. A., Vernieuw, C. R., Leammukda, W., Teal, W., Laprise, B., Cadarette, B. S., Kolka, M. A., Microclimate cooling activated by skin temperature feedback saves electrical energy. In preparation for publication. 
       FIG. 5A  is a schematic showing cooling of a human being  100  using skin temperature feedback. A cooling source  106  is connected to a garment  102  that is worn by the human being  100 . The garment  102  extracts heat from the human being  100  by, for example, liquid cooling, air cooling, or phase change. A device  104  for measuring skin temperature, such as a skin thermistor, is connected to a control  108  for the cooling source. 
     One aspect of the invention is a method of cooling the human being  100  that comprises measuring skin temperature of the human being; and, when the measured skin temperature reaches a preset high temperature, cooling the human being until the measured skin temperature reaches a preset low temperature and then ceasing cooling of the human being, otherwise known as “skin temperature feedback for microclimate cooling.” 
     In one embodiment of the cooling method, the preset high temperature is about 35 degrees Centigrade and the preset low temperature is about 33 degrees Centigrade. Cooling begins when the sensed skin temperature reaches about 35 degrees Centigrade and continues until the sensed skin temperature falls to about 33 degrees Centigrade. The cycle is repeated as necessary. 
       FIG. 5B  is a schematic showing heating of a human being  100  using skin temperature feedback. A heat source  110  is connected to a garment  102  that is worn by the human being  100 . The garment  102  adds heat to the human being  100  by, for example, liquid heating, air heating, or phase change. A device  104  for measuring skin temperature, such as a skin thermistor, is connected to a control  108  for the heating source. 
     Another aspect of the invention is a method of heating a human being  100  that comprises measuring skin temperature of the human being; and, when the measured skin temperature reaches a preset low temperature, heating the human being until the measured skin temperature reaches a preset high temperature and then ceasing heating of the human being, otherwise known as “skin temperature feedback for microclimate heating.” 
     In one embodiment of the heating method, the preset low temperature is about 33 degrees Centigrade and the preset high temperature is about 35 degrees Centigrade. Heating begins when the sensed skin temperature falls to about 33 degrees Centigrade and continues until the sensed skin temperature reaches about 35 degrees Centigrade. The cycle is repeated as necessary. 
     Another aspect of the invention is a body cooling apparatus  20  shown schematically in  FIG. 6 . Body cooling apparatus  20  includes a cooling garment  24  that is fitted on a human being  22 , a cooling source  26 , cooling connections  30 ,  32  between the cooling source  26  and the cooling garment  24 , at least one device  28  for measuring skin temperature and an electrical connection  34  between the skin temperature measuring device  28  and a control  36  for the cooling source  26 . 
     Cooling garment  24  may be, for example, a liquid cooling garment, an air cooling garment or a phase change cooling garment. Cooling source  26  may be, for example, a chilled water source, a cold air source, or a source of a phase change refrigerant. In one embodiment, garment  24  is a liquid cooling garment made of, for example, cotton or Nomex® aramid fabric woven or laminated around small diameter Tygon® tubing (2.5 mm, I.D.) divided into multiple parallel circuits. It should be noted that apparatus  20  may be readily adapted for body heating by exchanging a heat source for the cooling source  26 . 
     Garment  24  may be styled to cover any portion of the body. For example, as shown in  FIG. 7 , there may be a hood section  38  to cover the head, a vest section  40  to cover the torso and a pants section  42  to cover the legs. In an embodiment of the garment  24  that includes a hood section  38 , a vest section  40  and a pants section  42 , the percentage of body surface area covered is about sixty percent. For improved comfort, heat transfer tubes may be omitted from the crotch and buttocks areas. Preferably, the garment does not cover sensitive wear points such as elbows and the back of the knees. 
     The device  28  for measuring skin temperature may be, for example, a skin thermistor. A single thermistor or multiple thermistors placed at different locations on the body may be used. In the case of a single thermistor, the skin temperature used to control the cooling source  26  (or heating source) is measured by the single thermistor. If multiple skin thermistors are used, the mean weighted skin temperature may be calculated as 0.30 (upper body skin temperature)+0.20 (lower body skin temperature). See, e.g, Ramanathan, N. L., J. Appl. Physiol., 19: 931-933, 1964. The (upper body skin temperature) is the sum of two measurements on the upper body, for example, the chest and arm or the head and arm (or twice a single measurement). The (lower body skin temperature) is the sum of two measurements on the lower body, for example, the thigh and calf (or twice a single measurement). 
     By way of example,  FIG. 7  shows three thermistors  44 ,  46  and  48 . Assume thermistor  44  on the head reads 33 degrees, thermistor  46  on the chest reads 35 degrees and thermistor  48  on. the thigh reads 36 degrees. Using the above described relation, the mean skin temperature equals 0.30(33+35)+0.20(36+36) which equals 34.8. Other methods for calculating mean skin temperature may, of course, be used. 
     In one embodiment, cooling source  26  is a chilled water source that includes a heat exchanger and a vapor compression refrigerator. Heat generated by the human  22  is captured by the chilled water circulating through liquid cooling garment  24 . The chilled water returns to the chilled water source  26  and rejects the body heat through a heat exchanger to the working fluid of a vapor compression refrigerator. The heat exchanger and vapor compression refrigerator may be carried in a backpack or a belt pack. The refrigerator may be, for example, battery powered or internal combustion engine powered. The control  36  receives the mean skin temperature and controls the flow of chilled water to the liquid cooling garment. When the mean skin temperature reaches about 35 degrees Centigrade, the flow of chilled water is turned on. When the mean skin temperature reaches about 33 degrees Centigrade, the flow of chilled water is turned off. This cycle is repeated as long as cooling is desired. The control  36  may be, for example, a pump in the chilled water lines, a bypass valve that bypasses the heat exchanger, or other devices for controlling cooling systems. 
     While the invention has been described with reference to certain preferred embodiments, numerous changes, alterations and modifications to the described embodiments are possible without departing from the spirit and scope of the invention, as defined in the appended claims and equivalents thereof.