Abstract:
A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

Description:
BACKGROUND OF THE INVENTION 
     Field of the Invention 
     The invention relates to a metering device which can be activated by the user&#39;s suction airstream and is intended for the inhalation of a pulverulent substance, in particular a medicinal substance, according to the preamble of the main claim. 
     A metering device of the type in question is known from WO 2006/021546 A1. The quantity of substance separated off in the metering chamber is moved into a closed emptying-standby position. As a result of a user breathing in, a piston moves and opens the metering chamber. Thereafter, the latter is connected to an air-flow path for clearing the separated-off quantity of substance out of the metering chamber and transferring it into the airstream which is to be sucked in. 
     In view of this known prior art, it may be considered to be a technical problem of the invention to develop in an advantageous manner a metering device of the type in question in respect of optimum air channeling. WO 02/26299 has already proposed to use the suction airstream both for displacing a metering rod and for conveying the substance through the mouthpiece. These solutions, however, can only be used with the metering device in the upright position, that is to say they cannot be used, in practice, when the user is lying in bed. There is also a risk of the inhaler-substance mixture separating. 
     BRIEF SUMMARY OF THE INVENTION 
     The problem of optimum air channeling is solved substantially by the subject matter of the invention. Two airstreams meet in an annular chamber, one of the airstreams initially opening the metering chamber and then coming into contact with the other airstream in the annular chamber. The configuration selected for the piston means that only a relatively low mass needs to be shifted when the piston is displaced, but a large-area engagement surface is provided, and this makes it easier for the piston to be moved out of the emptying-standby position into the emptying-release position by means of the user&#39;s suction airstream. Accordingly, only a relatively low level of suction airstream energy is required in order to release the metering chamber. Furthermore, the narrow construction of the piston makes it possible to achieve increased levels of air energy during inhalation. 
     In an advantageous development, it is provided that, in its upper end position, the upper periphery of the piston engages in front of an annular wall, which belongs to an annular chamber, and preferably the ceiling of the latter has peripherally extending, projecting wings which leave intermediate spaces between them. Disposed downstream of the same is a ceiling portion which constitutes an oblique deflecting wall with concentrating action. Further preferably, the piston, which has air flowing around it during inhalation, i.e. during suction-air activation by the user, releases the path to the annular chamber in the upper position, i.e. in the emptying-release position of the metering chamber, with sealing engagement against the annular wall of the annular chamber. The annular chamber acts in the manner of a vortex chamber, in which the powder which is to be inhaled is distributed optimally in the suction air. The powder which is to be inhaled consists, for example, of a basic body, such as lactose, which can be transported by a suction stream and is suitable as a carrier for fine micronized drug particles adhering to its surface. These basic bodies are usually of different sizes. On account of the powder-laden suction air flowing through the annular chamber, the particles of powder are rendered more or less the same size, i.e. relatively large particles of powder are broken up as a result of the vortexing and the associated centrifugal forces. The powder-laden suction air is extracted by suction through the intermediate spaces which are formed between the wings extending radially outward from the cover and from where the suction air passes, in slightly concentrated form, into the mouthpiece of the metering device. It is possible to distribute, over the circumference of the cover, wings and interspaces of the same width, as seen in the circumferential direction. However, it is also possible to provide wings and/or interspaces of different widths in the circumferential direction. This creates at the end of the annular chamber, as seen in the direction in which flow takes place around the annular chamber, forced guidance of the powder-laden airstream, through an interspace provided correspondingly on the cover, into the mouthpiece. In a development of the subject matter of the invention, it is provided that some of the wings are of circumferentially wider configuration, in order to form a deflecting-wall wing for the powder-laden suction airstream. This wing is preferably directed, in first instance, in the axial direction of the annular chamber. The deflecting-wall wing forces the incoming suction airstream to deflect into a plane of circulation directed transversely to the annular chamber. By virtue of the deflecting-wall wing being acted upon at relatively high speed, relatively large particles of powder are broken up. The metering rod is retained in an inner cylinder, which can be rotated by the closure cap, such that it can be displaced along the axial extent of the inner cylinder. The rotation of the inner cylinder is transmitted to the metering rod. This inner cylinder is provided, on the lateral-wall side, with an axially running channel which extends from the emptying side of the metering chamber and terminates in the annular chamber, the deflecting-wall wing being provided in order to deflect the axial airstream direction into the orbital plane. Accordingly, this deflecting-wall wing is disposed in the manner of a cover in axial extension of the channel, with the radial outlet being left in the process. Via this channel, following the suction-air-induced raising operation of the piston and the associated release of the metering chamber, the separated-off dose of substance is sucked out and fed, via the annular chamber, to the user who is building up the suction airstream. In a preferred configuration, deflection from the radial flow direction into the axial flow direction is achieved by two channel deflection regions which are located directly one after the other and each cause flow to be deflected by 45 degrees. An intermediate channel portion which runs at an angle of approximately 45 degrees to a plane oriented transversely to the axis of the device, and connects the emptying side of the metering chamber to the axially running channel, is thus also preferably provided. 
     A total of two air-flow paths are created, of which the one causes the metering chamber to be emptied and the second leads directly into an annular chamber which is located upstream of the mouthpiece and where the two airstreams meet. Accordingly, the one particle-laden airstream established during the inhalation operation is channeled separately. The quantity of air which is required for inhalation is fed, in part, via the first air-flow path within the annular chamber. If the metering chamber is closed, the metering chamber can be opened via this air-flow path, for example via the suction-air-activated piston. By virtue of the air-flow paths being separated, a stream of air which is not laden with particles is formed initially. In the event of correct inhalation, approximately 50 liters of air per minute flow through the device, which quantities of air result from at least the two airstreams being added together, one fraction being fed, in first instance, via the first flow path, which opens the metering chamber. In a preferred configuration, this opening of the metering chamber, for example by virtue of a piston being displaced out of an emptying-standby position into an emptying-release position, takes place at an opening pressure of approximately 2 kPa, and furthermore with an airflow of 18 to 22 liters of air per minute. The airstream of the second air-flow path, which leads directly from the metering chamber into the annular chamber, the annular chamber being located upstream of the mouthpiece, has a significantly higher flow speed than the airstream which results in the metering chamber being emptied. 
     In a preferred configuration, the second airstream is sucked in through a grille-wall portion. The latter leaves a free opening cross-section which allows the necessary quantity of air to be easily sucked in. Further preferably, the air-inlet grille surface is located on the outer cylinder, which cannot be rotated in relation to the inner cylinder and continues the closure cap, on that side of the metering rod which is located opposite to the emptying direction of the metering chamber. This means that there is clear structural separation of the air-flow paths. 
     A compact construction of such a metering device is further achieved in that a flow channel directed toward the metering chamber is disposed beneath the air-inlet grille surface, even in the position assumed by the metering chamber in an emptying-standby position, and this flow channel even allows a visual check as to whether the metering chamber is full and/or closed. In a preferred configuration, this channel passes through the outer cylinder beneath the air-inlet grille surface for the first air-flow path in the region of an appropriately formed air-inlet opening. As a result of this configuration, the two air-flow paths open, in respect of the air-inlet openings, to the same side of the outer cylinder. Via the flow channel provided beneath the air-inlet grille surface, in the emptying-release position, the metering chamber is cleared preferably transversely to the device axis in order for the separated-off substance to be transported via the second air-flow path, passing through the annular chamber into the mouthpiece, all this being as a consequence of suction-air activation on the part of the user. In a further-preferred configuration, the interior of the inner cylinder is available entirely for the free distribution of the air sucked in through the air-inlet grille surface, and it is in flow connection with the annular chamber. 
     In a further configuration of the invention, the lateral wall of the outer cylinder has at least one air-inlet opening, preferably two radially opposite air-inlet openings. Further air-flow paths are achieved via these separate air-inlet openings, these further air-flow paths being separated from the other two air-flow paths at least in the emptying-standby position. It is thus provided, in an advantageous development of the subject matter of the invention, that the air-inlet openings open out in a tangentially directed manner into the annular chamber, a common flow direction being predetermined in the process, this further being a flow direction which is even predetermined by the other two air-flow paths. These air-inlet openings achieve a kind of initial ignition in order to deflect the rest of the air-flow paths in the desired flow direction within the annular chamber. 
     The substance which is to be inhaled is stored in a storage chamber, into which the metering chamber penetrates for filling purposes. In order to assist the filling operation of the metering chamber here, and furthermore to achieve the situation where the uppermost layer of the substance store, which has the metering chamber passing through it, is always loosened, a rotor-like blade is retained on the lower periphery of the inner cylinder, for example clipped thereon, which blade interacts with an inwardly directed stator-like shoulder of the storage-chamber wall. This allows the replenishment and the density of the substance in the storage chamber to be kept constant. Added to this is a loosening effect which is provided in the area surrounding the metering chamber and prevents fractions of the substance from coming to a halt. Furthermore, the rotor, in interaction with the stator, is configured such that, when the rotor-like blades are moved back when the closure cap is replaced and screwed on and the metering chamber is lowered into the storage chamber, the uppermost substance layer is subjected to slight contact pressure, in order thus to provide, in the storage chamber, an evened-out uppermost substance-quantity region associated with the metering chamber. 
     Finally, it has also proven to be advantageous to provide, in the region of the storage-chamber wall, a filling-level indicator which makes it possible to ascertain the amount of filling. In the simplest configuration, this can be coupled directly to the axial movement of a pressure piston which is disposed in the storage chamber and subjects the stored quantity of substance to loading from beneath in the direction of the inner cylinder. This pressure piston advances as substance is removed, and this can be observed via the filling-level indicator. 
     The invention is explained in more detail hereinbelow with reference to the accompanying drawing, which merely constitutes an exemplary embodiment and in which: 
    
    
     
       BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING 
         FIG. 1  shows the vertical section through a metering device according to the invention in the basic position, with the cap closed; 
         FIG. 2  shows a further vertical section along line II-II in  FIG. 1 ; 
         FIG. 3  shows an enlargement of an upper region of the device according to  FIG. 1 ; 
         FIG. 4  shows a sectional illustration corresponding to  FIG. 1 , relating to the situation where the storage chamber for the substance which is to be inhaled has been more or less emptied; 
         FIG. 5  shows the section along line V-V in  FIG. 4 ; 
         FIG. 6  shows a further illustration corresponding to  FIG. 1 , this time during removal of the closure cap; 
         FIG. 7  shows the section along line VII-VII in  FIG. 6 ; 
         FIG. 8  shows the vertical section according to  FIG. 1 , but following removal of the closure cap and the resulting displacement of a metering chamber into the emptying-standby position; 
         FIG. 9  shows the section along line IX-IX in  FIG. 8 ; 
         FIG. 10  shows a detail-view illustration corresponding to  FIG. 3 , relating to the situation according to  FIG. 8 ; 
         FIG. 11  shows a follow-up illustration to  FIG. 8 , but relating to a position assumed during inhalation; 
         FIG. 12  shows the section along line XII-XII in  FIG. 11 ; 
         FIG. 13  shows a further detail-view illustration corresponding to  FIG. 3 , but relating to the situation according to  FIG. 11 ; 
         FIG. 14  shows a further vertical-section illustration corresponding to  FIG. 1 , this time relating to an intermediate position as the closure cap is being replaced following completion of inhalation; 
         FIG. 15  shows a follow-up illustration to  FIG. 14 , relating to an intermediate position; 
         FIG. 16  shows a follow-up illustration to  FIG. 15 , relating to an intermediate position as the operation of screwing on the closure cap continues; 
         FIG. 17  shows the cross-section through the metering device in the emptying-standby position along line XVII-XVII in  FIG. 8 ; 
         FIG. 18  shows the cross-sectional illustration through the metering device along line XVIII-XVIII in  FIG. 11 ; 
         FIG. 19  shows an illustration which corresponds to  FIG. 17  and has been taken along line XIX-XIX in  FIG. 11 , relating to the emptying-release position; 
         FIG. 20  shows the section along line XX-XX in  FIG. 11  through the storage chamber, with the substance which is stored here having been left out; 
         FIG. 21  shows a perspective detail illustration of an inner cylinder of the metering device; 
         FIG. 22  shows a further perspective illustration of the inner cylinder; 
         FIG. 23  shows a perspective detail illustration of the metering rod of the metering device; 
         FIG. 24  shows a perspective detail illustration of the piston; 
         FIG. 25  shows a further perspective detail illustration of a rotor-like blade for disposing on the inner cylinder; 
         FIG. 26  shows a further perspective illustration of the rotor-like blade; and 
         FIG. 27  shows, in a detail drawing, the bottom view of a cover of an annular chamber. 
     
    
    
     DESCRIPTION OF THE INVENTION 
     The metering device  1  which is illustrated in the figures and is intended for the inhalation of a pulverulent substance  2 , in particular a medicinal substance, is realized as a short-elongate device which can readily be carried in a pocket and has a cylindrical housing  3  which determines its shape. 
     The cylindrical, tube-like housing  3  has, at the head end, an outer cylinder  4  which can be rotated about the device axis x relative to the housing  3 . This outer cylinder is secured in a rotatable manner on the housing  3  in the region of an end-side radial step  5 . 
     This likewise cylindrical, tube-like outer cylinder  4  merges, at the head end of the device  1 , into an attached mouthpiece  6  which is formed appropriately for the mouth, for example is flattened. This mouthpiece  6  can have a cup-like closure cap  7  engaging over it in a protective manner. This closure cap is realized as a screw cap for which reason an associated internal thread  8  engages in a corresponding external thread  9  on the lateral wall of the housing  3 . 
     The outer cylinder  4  is connected to the closure cap  7  in a rotationally fixed manner, for which reason the outer cylinder has, on the outside of its lateral wall, vertically oriented ribs  10  which interact with correspondingly positioned, slot-like vertical grooves  11  on the inside of the wall of the closure cap  7 . Accordingly, screw-action actuation of the closure cap  7  causes the outer cylinder  4  to be rotated about the device axis x. 
     At the foot end, the end periphery of the cup-like closure cap  7  engages in a stop-limiting manner, and with sealing via a cone, against an annular shoulder  12 , which is achieved on account of the abovementioned step of the cylindrical housing  3 . 
     The closure cap  7  serves, at the same time, as an actuating handle  13  for dispensing the pulverulent substance  2  in reproducible sub-quantities  14 , for which purpose use is made of the axial screw-action displacement provided by the threaded engagement between the internal thread  8  and external thread  9 . The substance  2  is accommodated (possibly such that it can be refilled) in a storage chamber  15  of the housing  3 . A metering device conveys a respective sub-quantity  14  of substance to a transfer location U located outside the storage chamber  15 . 
     The meterable substance is a (usually medicinal) pulverulent substance  2 . It is possible for basic bodies such as lactose, which are capable for example of transporting a suction stream, to be carriers for fine micronized drug particles adhering to the surface. 
     The storage chamber  15  is terminated at the bottom by a cup-like pressure-exerting base  16 , which is spring-loaded in the direction of the mouthpiece  6  by means of a compression spring  17 . The compression spring  17  has its foot-side end turn supported on a base cap  18 , which closes the housing  3  there. This base cap is in latching engagement with that portion of the housing  3  which is of larger cross-section here on its inside wall, a corresponding latching collar  19  of the base cap  18  engaging in a matching annular groove of the housing  3 . 
     The head-side end turn of the biased compression spring  14  subjects an inner shoulder  20  of a hollow piston  21  of the piston-like means  16 / 21  to loading action. As can be seen from the illustrations, the pressure-exerting base  16 , which is in the form of a graduated cup, is connected with latching action to the hollow piston  21  in the region of the inner shoulder  20 . 
     The cup periphery of the pressure-exerting base  16  forms an annular lip  22  which, on account of its elastomeric material, strips substance off the wall of the storage chamber  15  without leaving any residues. 
     In the exemplary embodiment illustrated, the compression spring  17  is a cylindrical spring which, in the state in which it is relieved of stressing, has a length corresponding approximately to ten times the maximum contact-pressure length. The contact-pressure length is defined by the extent of axial displacement of the pressure-exerting base  16  between a lower position according to  FIG. 1 , this position corresponding to the filling position, and an upper, stop-limited position of the pressure-exerting base  16  in the storage chamber  15  according to  FIG. 4 . Thus, the exemplary embodiment illustrated provides a contact-pressure length of 15 mm. As a result of the configuration of the spring, in particular as a result of the selected length of the spring, the pressure-exerting base  16  is subjected to a constant spring pressure over the entire contact-pressure length, and this leads to the substance being compressed uniformly throughout the duration of use of the device  1 . 
     A hollow upright stub  23  extends centrally from the base cap  18 . Together with the hollow piston  21  which encloses it at a distance apart, this hollow upright stub forms a chamber  24  for the compression spring  17 . The hollow upright stub  23  contains, in its center, a moisture-absorbing material in the form of a drying-agent capsule  25 . At the transition to the outer cylinder  4 , which follows the housing  3  in the axial direction, the storage chamber  15  terminates with a chamber ceiling  26  formed integrally with the lateral wall of the storage chamber  15 . Passing through the center of this chamber ceiling is a cylinder portion  27  of a rotary part  28  which extends in a plane perpendicular to the device axis x. This rotary part is of substantially plate-like configuration and is connected in a rotationally fixed manner to the outer cylinder  4  and, accordingly, can be rotated about the device axis x in relation to the chamber ceiling  26 . The cylinder portion  27  extends on the underside of the rotary part  28 , passing through the chamber ceiling  26 . The lower free end surface of the cylinder portion  27  is located in the plane of that surface of the chamber ceiling  26  which covers the storage chamber  15 . 
     The diameter of the through-opening in the chamber ceiling  26  is larger than the diameter of the cylinder portion  27 . A holder, of annular shape in plan view, for a rotor blade R, is positioned in the annular gap which remains. This rotor blade is connected in a rotationally fixed manner to the cylinder portion  27 . 
     The inner surface of the rotor ring  30 , this inner surface being directed toward the storage chamber  15 , is located in the plane of the correspondingly directed end surface of the cylinder portion  27 . 
     The rotor R, which is illustrated on its own in  FIGS. 22 and 23 , carries on the underside, that is to say in the direction toward the storage chamber  15 , a blade  29 . This is a blade  29  which is in the form of a spherical-cap portion and projects radially outward beyond the ring  30  of the rotor R. The blade  29  correspondingly engages beneath that region of the chamber ceiling  26  which adjoins the rotor R radially on the outside, that surface of the blade  29  which is directed toward the chamber ceiling  26  being of planar configuration. This surface of the blade  29  engages against the top surface of the chamber which is directed toward the blade. The blade  29  extends radially as far as the inner wall of the storage chamber  15 . From this radially outer region, the blade  29  slopes up convexly in the radially inward direction, as seen in cross-section, to an axial height corresponding approximately to the extent by which the blade  29  projects radially beyond the rotor ring  30 . 
     As a result of this arrangement, the blade  29  of the rotor R projects into the substance stored in the storage chamber  15 . The shoulder formed by the chamber ceiling  26 , in interaction with the blade  29  or rotor R, which can be rotated relative to the storage chamber  15 , forms a stator St. 
     The rotor R is clipped on the cylinder portion  27  of the rotary part  28  via the rotor ring  30 . 
     The cylinder portion  27  accommodates a sealing bushing  31  in its center. This bushing consists of a rubber material or a similar elastic material. This leaves, in its center, a cross-sectionally slot-like guide opening  32  for a cross-sectionally adapted metering rod  33 . 
     In the simplest configuration, the sealing bushing  31  and also an annular seal  35  provided between the rotary part  28  and a housing portion  34 , which engages over the chamber ceiling  26  on the housing side, may be produced by two-component injection molding together with the rotary part  28  and, furthermore, with an inner cylinder, which will be described in more detail. It is also possible in this respect, however, for the rubber or elastomer parts to be provided subsequently during production. 
     At the foot end, the hollow piston  21 , which is connected with latching action to the pressure-exerting base  16 , has a radial extension arm  36 . Integrally formed on the latter is an axially oriented indicating protrusion  37  which engages over the storage-chamber wall on its outside. The axial position of this indicating protrusion, this position being reached in dependence on the position of the pressure-exerting base, can be seen by the user from the outside through a viewing window  38  provided in the housing. A filling-level indicator  39  is provided as a result. 
     The metering rod  33  is appropriately configured for functioning as a moving metering chamber  40  for the sub-quantity  14  of substance which is to be dispensed, the metering rod  33  moving linearly along the longitudinal center axis x-x of the substantially rotationally symmetrical device  1 , and this being accompanied by a rotary movement executed about the longitudinal center axis x-x. The metering rod  33  is formed substantially as a flat part with an elongate-rectangular cross-section. The length ratio of narrow side to broad side is approximately 1:3 in the exemplary embodiment illustrated. 
     At the end which is directed away from the mouthpiece  6 , the metering rod  33  forms a portion which tapers to a point more or less in the manner of a cross-recessed screwdriver tip. The two mirror-symmetrical oblique flanks here extend from the respective broad sides of the metering rod  33  (cf.  FIG. 20 ). 
     On account of the metering rod  33  being carried along in rotation, the cross-sectional configuration of the metering rod  33  and the tapering of the free end region have a loosening, displacing effect in the central region in relation to the mass of pulverulent substance  2 . 
     The metering chamber  40  is realized as a transverse hole which runs substantially perpendicularly to the longitudinal center axis x-x and has an axis which passes through the broad-side surfaces of the metering rod  33 . The transverse hole is formed conically, so that the transverse hole tapers in the direction of one broad-side surface of the metering rod  33 . Furthermore, as can be seen for example from the illustration in  FIG. 2 , the metering chamber  40 , which is formed in the region of that end of the metering rod  33  which projects into the mass of substance, is disposed eccentrically in relation to the broad-side surfaces of the metering rod  33 , that is to say it is offset laterally in relation to the longitudinal axis x-x. 
     The displacement path of the metering chamber  40 , which moves linearly, and, at the same time, in rotation, allows, in both end positions of the metering rod  33 , for the cross-section of the guide opening  32  to be kept closed, with metering-chamber-filling scraping or stripping action over the length of the said opening  33 . 
     The mouthpiece end of the closure cap  7  forms a docking location  41  between the metering rod  33  and closure cap  7 , this docking location disengaging when subjected to overloading. The latching means on the closure-cap side here is a resilient hook annulus which is formed in the region of the free end of a hollow cylinder  43  disposed centrally on the underside of a closure-cap ceiling  42 . The corresponding end of the metering rod  33  is rotationally symmetrical in cross-section, a disk-like radial collar  44 , furthermore, projecting out in the transition region from the flat-part portion to the cylindrical end portion. At an axial spacing from this radial collar  44 , that end region of the metering rod  33  which is directed away from the flat part forms a latching head  45 . A wasp-waist-like annular groove  46  is formed between this latching head and the radial collar  44 . Inwardly directed noses  47  of the resilient tongues of the hook annulus engage in this annular groove. The noses  47  can pass over the latching head  45  in both axial directions. The latching action may be fairly tight, since it is released and reinstated during the screwing-action displacement of the cap. 
     The central opening  48  of the mouthpiece  6  is formed in the region of a dispersing part  49 . This dispersing part  49  opens conically outward, that is to say in the direction away from the storage chamber  15 , the wall  50  of the dispersing part merging, in the direction toward the storage chamber  15 , into an annular, roof-like ceiling portion  51 . At the same time, the latter forms the upper terminal of the outer cylinder  4 , which carries the mouthpiece  6 . 
     The central free space created by the dispersing part  49  has the hollow cylinder  43 , which carries the noses  47 , passing through it centrally in the cap-closed position. The annular space which forms here between the hollow cylinder  43  and the dispersing-part wall is filled by a further drying-agent capsule  52  in the cap-closed position. 
     The outer cylinder  4  accommodates an inner cylinder  53 , passing through the center of which is the metering rod  33  and, in the cap-closed position, the hollow cylinder  43  belonging to the closure cap. The inner cylinder is connected in a rotationally fixed manner to the outer cylinder  4 . 
     This inner cylinder  53  is configured substantially as a hollow body and carries, in its center, an axially displaceable piston  54 . The piston  54  is guided more or less in the lower half of the inner cylinder  53 , directed toward the storage chamber  15 , by a cross-sectionally round guide portion  55 . 
     That portion of the inner cylinder  53  which is directed away from the storage chamber  15  forms a piston-head displacement region  56  which has a cross-section larger than that of the guide portion  55  and of which the axially oriented wall  57  has radial openings  58 ,  58 ′ and  58 ″. These radial openings are in flow connection with a grille-wall portion  59  of the outer cylinder. 
     Formed beneath the grille-wall portion  59 , and furthermore at the foot end of the guide portion  55  of the inner cylinder, is a radially oriented flow channel  60 , which likewise opens toward the grille-wall portion  59 . This flow channel may also serve as a window for visually monitoring the metering rod  33 . It opens out into the free space left in the center by the guide portion  55 . Radially opposite the flow channel  60 , the guide portion  55  is adjoined by an intermediate channel portion  61  which, starting from the guide portion  55 , and with the inclusion of an angle of 45° in relation to a plane oriented perpendicularly to the axis x, slopes up in the direction of the associated wall of the outer cylinder  4  in order then to merge, at the end, into an axially directed channel  62 . This channel  62  is formed by an axially oriented, slot-like, radially outwardly opening recess in the lateral surface of the inner cylinder. The channel  62  is covered over radially by the associated wall of the outer cylinder  4 . 
     As well as the radial opening  58 , which can be seen by way of example in the sectional illustration in  FIG. 1 , two further radial openings  58 ′ and  58 ″ are provided, and these each enclose, as seen in a plane oriented transversely to the axis x, an angle of 90° in relation to this radial opening  58  and, by virtue of the inner-cylinder wall being configured appropriately, are in direct air-flow connection with the grille-wall portion  59 . 
     The axially oriented channel  62  has its end which is directed toward the mouthpiece  6  opening out into an annular chamber  63 . The latter forms a vortex chamber. The ceiling  64  of the latter is of cross-sectionally roof-like configuration and is provided with peripherally extending, projecting wings  65 ,  66 . These engage peripherally against the inner wall of the outer cylinder  4  and, as seen in the circumferential direction, leave intermediate spaces  67  between them, through which an air-flow connection is achieved between the annular chamber  63  and a further annular space  68  left between the dispersing-part ceiling portion  51  and the annular-chamber ceiling  64 . 
     The ceiling  64  is secured on the inside wall of the inner cylinder  53  by an axially directed flange  69 . 
     The base of the annular chamber  63  is formed by an annular collar  70  which projects radially outward on the outside wall of the inner cylinder  53  at an axial spacing from the wings  65 ,  66  of the ceiling  64 . It is also the case that this annular collar is supported peripherally on the inside wall of the outer cylinder  4 . This annular collar  70  is interrupted by the axially oriented channel  62 . The annular chamber  63  is bounded in the radially inward direction by an end-side wall portion which belongs to the inner cylinder  53  and serves for latching the ceiling  64 . The resulting annular-chamber wall is provided with slot-like through-passages  71  in order to provide air-flow connection between the annular chamber  63  and the piston-head displacement region  56 . 
     As can furthermore be seen, in particular, from the sectional illustration in  FIG. 18 , the outer-cylinder wall is provided, level with the annular chamber  63 , with two diametrically opposite air-inlet openings  72 . These open out tangentially into the annular chamber  63 , and this, furthermore, predetermines a common flow direction. Accordingly, a sucking-in action through the air-inlet openings  72  results in a predetermined air flow in the annular chamber  63 . The axially oriented channel  62  opens out, as seen in the flow direction, immediately downstream of the mouth of one air-inlet opening  72  in the annular chamber  63 , so that the airstream entering into the annular chamber  63  through the axial channel  62  is deflected specifically in the desired vortexing direction via the air-inlet openings  72 . 
     The wings of the ceiling  64  are of different widths as seen in the circumferential direction. Thus, two diametrically opposite wings  65  are approximately three times the width of the rest of the wings  66 , as seen in the circumferential direction. One of these broader wings  65  covers over the mouth region of the axial channel  62  into the annular chamber  63  and, accordingly, forms a deflecting-wall wing  73  for the suction airstream entering into the annular chamber  63  through the axial channel  62 . 
     As can further be seen, in particular, from the illustration in  FIG. 27 , the wings  66  extend circumferentially, in the exemplary embodiment described, over an angle β of 15°. The intermediate spaces  67  left between the wings  66  and  65  likewise extend circumferentially over an angle α of 15°, while the peripheral edges of the broader wings  65  enclose an angle δ of 45°. 
     Other distributions are also possible in this respect (for example smaller wings—larger intermediate spaces; larger wings—smaller intermediate spaces; irregular configuration of wings and intermediate spaces). 
     An interrupter  74  is disposed in the annular chamber  63  adjacent to the mouth of the axial channel  62  in the annular chamber  63 , the interrupter being in the airflow direction through the air inlet openings  72 . This interrupter limits the circumferential path of the annular chamber  63  and, accordingly as a result of this configuration, this path is of an interrupted form rather than being annular throughout. The rear flank of the interrupter  74 , this flank being oriented counter to the flow direction, constitutes a run-on slope  75 , connecting the annular-chamber base to the annular-chamber ceiling, which contains the intermediate spaces  67 . This causes the airstream in the end region of the annular chamber  63  to be forcibly deflected axially upward into the further annular space  68 . 
     The piston  54 , which is retained in a rotationally fixed, but axially displaceable manner, in the inner cylinder  53 , has, in first instance, a piston head  76  which opens in disk form in the direction of the mouthpiece. This piston head opens conically in cross-section. Two parallel, axially oriented tongues  77  are integrally formed on the underside of the piston disk. The piston  54  consist of a rubber-like material. 
     Along their lower free periphery, the tongues  77 , which accommodate the cross-sectional contour of the guide portion  55  of the inner cylinder  53  on their outside wall, are split in a lip-like manner and, furthermore, in their free peripheral region, they have material-reinforced sealing surfaces  78 . 
     The flat part of the metering rod  33  is guided between the tongues  77 , the sealing surfaces  78 , in interaction with the flat part of the metering rod  33 , having a stripping and sealing action. 
     In a basic position of the device according to the illustration in  FIG. 1 , the free peripheries of the tongues  77 , these peripheries being split in a lip-like manner, engage, within an axial depression, against the upper side of the cylinder portion  27 . 
     Furthermore, in this basic position, the disk-like piston head  76  rests in a stop-limited manner on a base region of the piston-head displacement region  56 . The encircling peripheral region of the free end of the piston head  76  engages with sealing action against the associated inner wall of the inner cylinder  53 . 
     Furthermore, in this basic position, the head of the metering rod  33 , that is to say the radial collar  44  and latching head  45  of the same, rests in the depression created by the disk-like configuration of the piston head  76 . 
     The piston head  76  here is located at an axial distance beneath the ceiling  64 . 
     The device  1  cited functions as follows: 
     In order to prepare for inhalation, the closure cap  7  is first of all removed by unscrewing. As the closure cap  7  is being unscrewed upward, the coupling mentioned results in the outer cylinder  4  being carried along in rotation and, via this outer cylinder, the inner cylinder  53  as well as, in the exemplary embodiment cited, all those parts above the storage-chamber plane which are not connected in a rotationally fixed manner to the housing  3 . Accordingly, the metering rod  33  is also carried along in rotation, and furthermore, the action of the closure cap  7  being unscrewed upward gives rise, at the same time, to axial displacement of the metering rod  33  via the docking location  41 , which causes helical displacement of the metering chamber  40  into the as yet closed emptying-standby position B according to the illustration in  FIGS. 6 and 7 , in which it is aligned with the flow channel  60 . 
     By virtue of the metering chamber  40  being disposed eccentrically in relation to the axis of rotation of the metering rod  33 , it is filled optimally as a result of penetrating helically through the mass of substance, assisted by the rotor. The larger-diameter opening surface of the metering chamber  40  here is oriented in the direction of rotation. 
     The simultaneously rotating blade  29  of the rotor R here causes the surrounding mass of substance to be in a constantly loosened state, a shoveling effect being achieved. When the rotor R rotates in the opposite direction—as the closure cap  7  is screwed on again—the blade  29  interacts with the stator St in order to scrape off substance  2  from the surface of the stator and to press the substance  2  down, as a result of which the mass of substance is evened out. The blade  29  of the rotor R, accordingly, acts on the mass of substance in both directions of rotation. 
     When the removal-standby position B of the metering rod  33  is reached, the metering rod is secured with latching action. For this purpose, the radial collar  44  of the metering rod  33  moves behind latching fingers  79  which are formed on the underside of the ceiling  64 . 
     As the screwing-action displacement of the closure cap  7  continues, the latching in the region of the docking location  41  between the hollow cylinder  43  and the metering rod  33  is eliminated. Accordingly, the noses  47  leave the annular groove  46 , whereupon the closure cap  7  can be removed. The device  1  is now prepared for inhalation. 
     The screwing-action displacement of the closure cap  7  makes it possible to provide sufficient force for producing the latching between the radial collar  44  and latching fingers  79  and, furthermore, for eliminating the latching between the latching head  45  and noses  47  on the cap. 
     The tongues  77  of the piston  54  cover over the metering chamber  40  on each side. Accordingly, in this position, it is not possible for the sub-quantity  14  of substance to trickle out even in part. Rather, the substance is held reliably captive in the metering chamber  40 . This prevents cases of double metering when inhalation is not carried out, but the device is closed-off again via the closure cap  7 . Furthermore, in the removal-standby position B of the metering chamber  40 , it is also possible for the device  1  to be put to one side. Even if the device  1  experiences normal kinds of impacts, this does not result in the sub-quantity  14  of substance which is to be inhaled trickling out, which would falsify the inhalation result. 
     The inhalation operation takes place automatically by the user subjecting the device to suction air, in the simplest case by the user breathing in. 
     Air is sucked in via the mouthpiece  6 , and this, in first instance, by virtue of the piston head  76  being subjected to the action of air, results in the piston  54  being displaced axially in the direction of the ceiling  64 . In the case of the exemplary embodiment illustrated, the pressure required to trigger the device is approximately 2 kgPa. Triggering takes place, as far as possible, in abrupt fashion. 
     In the raised position, the upper free peripheral region of the piston head  76  engages against the underside of an annular wall  80  of the ceiling  64 . The annular space of the inner cylinder  53  which then encloses the free peripheral region of the piston head  76  is widened radially, as a result of which radial flow takes place around the piston  54  in the region of the piston head  76 . This gives a main airstream a which flows through the grille-wall portion  59 , passing through the radial openings  58 ,  58 ′ and  58 ″, into the piston-head displacement region  56  and passes, by way of the annular-space region left radially outside the piston head  76 , through the openings  71  into the annular chamber  63 . Approximately 85 to 90% of the total inhalation air volume is transported via this air-flow path. 
     At the same time, via the always open radial air-inlet openings  72 , air is sucked in directly into the annular chamber  63 , in order to predetermine the vortexing direction in the annular chamber  63 . 
     By virtue of the axially displaced piston  54 , the tongues  77  are likewise displaced axially, in order to release the metering chamber  40 . The axial displacement of the piston  54  is assisted by the guide portion  55 , which accommodates the tongues  77 , widening slightly in the direction of the piston head  76 , as a result of which there is a reduction in the friction between the tongues  77  and the wall of the guide portion  55 . It is also the case that the friction between the tongues  44  and the flat part of the metering rod  33  is minimized, being on the region of the sealing surfaces  78 . 
     The metering chamber  40  is then located in a removal-release position F, in which it lies freely in the flow path between the flow channel  60  and intermediate channel portion  61 . In the exemplary embodiment illustrated, approximately 10 to 15% of the inhalation air volume is transported via this substance-transporting airstream b. 
     The metering chamber is cleared out with through-suction from the flow channel  60 , this, furthermore, taking place from the smaller opening surface in the direction of the larger opening surface of the metering chamber  40 . The two-fold deflection through in each case approximately 45° into the angled intermediate channel portion  61  and, from the latter, into the axially oriented channel  62  results, in the manner of a baffle-plate effect, in the initial breaking up of relatively large particles of powder, which further leads to an improved inhalation result. 
     The substance-laden airstream flowing axially, at relatively high speed, into the annular chamber  63  via the channel  62  is deflected via the deflecting-wall wing  73  and, assisted by the initial flow by way of the radial air-inlet openings  72 , in the circumferential direction. Relatively large particles of powder are further broken up on this deflecting-wall wing  73 . 
     As a result of this configuration, the substance-laden airstream is guided outside the piston region. The piston  54  merely has powder-free air flowing around it. 
     Optimum distribution of the sub-quantity  14  of substance which is to be inhaled is achieved in the annular chamber  63 . The substance-laden air passes out through the intermediate spaces  67  for inhalation. Relatively heavy particles of powder which have possibly not been broken up, or have not been sufficiently broken up, are directed into the annular space  68  at the latest via the interrupter  74 . 
     In the annular chamber  63 , the initially substantially axially inflowing airstreams a and b are directed in a common horizontal direction of circulation in order then to pass jointly into the mouthpiece  6 , with axial passage through the ceiling  64 . 
     A number of features are provided in order to indicate successful inhalation to the user. In first instance, a visual check can be carried out in that the piston  54 , once raised by suction air, is retained in its raised position on account of the, albeit low, frictional forces present. The piston  54 , or the tongues  77  thereof, can be seen in the removal-standby position B through the radially outwardly open flow channel  60 . This can be further assisted by the tongues  77  being conspicuously colored. Once inhalation has taken place and the piston  54  has been raised correspondingly, the tongues  77  cannot be seen. Rather, there is a free view of the empty metering chamber  40 . It is also the case that the action of the piston  54  striking against the underside of the sealing  64  can be sensed both acoustically and by touch. 
     Once inhalation has taken place, and alternatively also if it is not desired to effect inhalation from the removal-standby position B, the closure cap  7  is screwed on again, the latching between the radial collar  44  and the latching fingers  79  being eliminated in first instance by virtue of the latching head  45  being acted upon by the noses  47 . The retaining forces of this latching connection are of a correspondingly smaller magnitude than the amount of force which is necessary for deflecting the noses  47 . As the action of screwing the closure cap  7  downward continues, the radial collar  44  on the metering rod displaces the piston  54  back again into its basic position. At the same time, with axial displacement and corresponding rotary movement, the metering rod  33  is displaced downward into the storage chamber. The action of the piston  54  being displaced back via the metering rod  33  terminates with the free ends of the tongues  77 , which are formed in the manner of lips, striking against the facing ceiling surface of the cylinder part  27 . As the downward-screwing displacement continues, finally the noses  47  enter into the annular groove  46  of the metering rod  33 . This final latching action is discernable to the user acoustically and by touch, to indicate that the closing operation is at an end. It is thus also ensured that a latching action between the metering rod  33  and closure cap  7  which causes the metering rod  33 , and thus the metering chamber  40 , to be carried along into the removal-standby position B is only achieved in the lowermost position of the metering rod  33 , in which position the metering chamber  40  is filled. Accordingly, there is always a filled metering chamber  40  available when the metering rod  33  is raised. 
     Incorrect operation is reliably avoided. Improper closure of the device  1  means that, during the next attempt at inhalation, the metering rod  33 , which has accordingly not been raised, on the one hand closes the passage between the flow channel  60  and intermediate channel portion  61  by way of its flat-part portion. It is also the case that the metering rod  33  continues to act on the associated surface of the piston head  76  via the radial collar  44 . Accordingly, when an attempt is made at inhalation, the closure of the flow channel  60  and the blocking of the piston  54  means that it is not possible to build up any air flow (with the exception of the small amount of flow via the small radial air-inlet openings  72 ). This clearly signals incorrect positioning to the user. This can only be eliminated by the device  1  being properly closed. 
     All features disclosed are (in themselves) pertinent to the invention. The disclosure content of the associated/attached priority documents (copy of the prior application) is hereby also included in full in the disclosure of the application, also for the purpose of incorporating features of these documents in claims of the present application. 
     LIST OF REFERENCE SIGNS 
     
         
           1  Device 
           2  Substance 
           3  Housing 
           4  Outer cylinder 
           5  Radial step 
           6  Mouthpiece 
           7  Closure cap 
           8  Internal thread 
           9  External thread 
           10  Ribs 
           11  Grooves 
           12  Annular shoulder 
           13  Actuating handle 
           14  Sub-quantity of substance 
           15  Storage chamber 
           16  Pressure-exerting base 
           17  Compression spring 
           18  Base cap 
           19  Latching collar 
           20  Inner shoulder 
           21  Hollow piston 
           22  Annular lip 
           23  Upright stub 
           24  Spring chamber 
           25  Drying-agent capsule 
           26  Chamber ceiling 
           27  Cylinder portion 
           28  Rotary part 
           29  Blade 
           30  Rotor ring 
           31  Sealing bushing 
           32  Guide opening 
           33  Metering rod 
           34  Housing portion 
           35  Annular seal 
           36  Radial extension arm 
           37  Indicating protrusion 
           38  Viewing window 
           39  Filling-level indicator 
           40  Metering chamber 
           41  Docking location 
           42  Closure-cap ceiling 
           43  Hollow cylinder 
           44  Radial collar 
           45  Latching head 
           46  Annular groove 
           47  Noses 
           48  Mouthpiece opening 
           49  Dispersing part 
           50  Wall 
           51  Ceiling portion 
           52  Drying-agent capsule 
           53  Inner cylinder 
           54  Piston 
           55  Guide portion 
           56  Piston-head displacement region 
           57  Region wall 
           58  Radial opening 
           58 ′ Radial opening 
           58 ″ Radial opening 
           59  Grille-wall portion 
           60  Flow channel 
           61  Intermediate channel portion 
           62  Channel 
           63  Annular chamber 
           64  Ceiling 
           65  Wing 
           66  Wing 
           67  Intermediate spaces 
           68  Annular space 
           69  Flange 
           70  Annular collar 
           71  Openings 
           72  Air-inlet openings 
           73  Deflecting-wall wing 
           74  Interrupter 
           75  Run-on slope 
           76  Piston head 
           77  Tongues 
           78  Sealing surfaces 
           79  Latching finger 
           80  Annular wall 
         x Device axis 
         B Removal-standby position 
         F Removal-release position 
         R Rotor 
         St Stator 
         U Transfer location 
         α Angle of intermediate spaces  67   
         β Angle of wings  66   
         δ Angle of wings  65   
         a Main airstream 
         b Substance-transporting airstream