Abstract:
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.

Description:
STATEMENT OF GOVERNMENT INTEREST 
       [0001]    This application was supported by Grant No. 1R21CA135463-01, 1R21CA122126-01 and 1R01CA140617-01A2 awarded by National Institutes of Health and the National Cancer Institute. The U.S. government has certain rights in the invention. 
     
    
     BACKGROUND OF THE INVENTION 
       [0002]    1. Field of the Invention 
         [0003]    The present invention relates to small molecules having high affinity and specificity to prostrate-specific membrane antigen (PSMA) and methods of using them for diagnostic and therapeutic purposes. 
         [0004]    2. Summary of the Related Art 
         [0005]    Prostate-specific membrane antigen (PSMA) is uniquely overexpressed on the surface of prostate cancer cells as well as in the neovasculature of a variety of solid tumors. As a result, PSMA has attracted attention as a clinical biomarker for detection and management of prostate cancer. Generally, these approaches utilize an antibody specifically targeted at PSMA to direct imaging or therapeutic agents. For example, ProstaScint (Cytogen, Philadelphia, Pa.), which has been approved by the FDA for the detection and imaging of prostate cancer, utilizes an antibody to deliver a chelated radioisotope (Indium-111). However, it is now recognized that the ProstaScint technology is limited to the detection of dead cells and therefore its clinical relevance is questionable. 
         [0006]    The success of cancer diagnosis and therapy using antibodies is limited by challenges such as slow elimination of these biomolecules from the blood and poor vascular permeability. In addition, large antibodies bound to cell-surface targets present a barrier for subsequent binding of additional antibodies at neighboring cell-surface sites resulting in a decreased cell-surface labeling. 
         [0007]    In addition to serving as a cell-surface target for antibodies delivering diagnostic or therapeutic agents, a largely overlooked and unique property of PSMA is its enzymatic activity. That is, PSMA is capable of recognizing and processing molecules as small as dipeptides. Despite the existence of this property, it has been largely unexplored in terms of the development of novel diagnostic and therapeutic strategies. There are a few recent examples in the literature that have described results in detecting prostate cancer cells using labeled small-molecule inhibitors of PSMA. 
         [0008]    Certain phosphoramidate PSMA inhibitors have been described in U.S. Pat. No. 7,696,185 to Berkman. 
       SUMMARY OF THE INVENTION 
       [0009]    The present invention comprises compounds that bind to the prostate-specific membrane antigen (PSMA) with high affinity and specificity. 
         [0010]    In one aspect, the present disclosure comprises compounds of one of the formulae, 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein each variable is as defined herein. 
         [0011]    In another aspect, the present invention comprises compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent. 
         [0012]    In another aspect, the present invention comprises diagnostic methods for detecting and/or identifying cells presenting PSMA comprising contacting (or causing to be contacted) a cell suspected of presenting PSMA with a compound of the invention. 
         [0013]    In another aspect, the present invention comprises compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent. 
         [0014]    In another aspect, the present invention comprises methods for inhibiting or treating prostrate cancer comprising administering to a patient having prostrate cancer a therapeutically effective amount of a compound of the invention linked to a prostrate cancer therapeutic agent (or a composition thereof). 
         [0015]    In another aspect, the present invention comprises methods for blocking or destabilizing neovasculature of a tumor, comprising administering to a patient having a tumor; or contacting a tumor cell with a therapeutically effective amount of a compound or composition of the invention. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0016]      FIG. 1  shows uptake of DTPA-SCN-CTT-54 labeled with pertechnetate ( 99m TcO 4 ) reduced with SnCl 2  by LNCaP (PSMA+) and PC3 (PSMA−) cells. 
           [0017]      FIG. 2  shows uptake DTPA-SCN-CTT-54 labeled with  99m Tc(CO) 3  by LNCaP (PSMA+) and PC3 (PSMA−) cells. 
           [0018]      FIG. 3  shows biodistribution of the  99m Tc-labeled probe in a LNCaP PSMA+ tumor xenograft model 4 hours following tail-vein probe injection. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0019]    In embodiment (1) of the first aspect, the invention comprises the compound of formula (I), 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    and pharmaceutically acceptable salts thereof wherein
   X and Y are independently —O— or —N(R)—, wherein each R is independently hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, —C 1 -C 7  alkylheteroaryl, or a protecting group;   m is 1, 2, 3, 4, 5, or 6;   n is 1, 2, 3, 4, 5, or 6;   R 1  and R 2  are each independently —C(O)OR 3 , —C(O)N(R 3 ) 2 , —P(O)(OR 3 ) 2 , —OP(O)(OR 3 ) 2 , —S(O) 2 R 3 , —S(O) 2 OR 3 , —S(O) 2 N(R 3 ) 2 , or tetrazolyl;   each R 3  is independently hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, —C 1 -C 7  alkylbeteroaryl, or a protecting group;   R 4  is hydrogen, —C(O)OR 3 , —C(O)N(R 3 ) 2 , —P(O)(OR 3 ) 2 , —OP(O)(OR 3 ) 2 , —S(O) 2 R 3 , —S(O) 2 OR 3 , —S(O) 2 N(R 3 ) 2 , or tetrazolyl;   R 5  is hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, —C 1 -C 7  alkylheteroaryl, or a protecting group;   each R 6  is independently hydrogen, C 1 -C 4  alkyl, or fluoro;   M is —O—, —S—, —N(R 31 )—, or —CH 2 —, wherein R 31  is hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, —C 1 -C 7  alkylheteroaryl, or a protecting group;   R 7  is -L-R 10 , wherein
       L is —C(O)—, -(Pep)-C(O)—, —C(O)N(H)—, —O(O)O—, —C(S)N(H)—, or —C(S)O—, wherein   Pep is a polypeptide of 1-20 amino acids; and   R 10  is -aryl-R 9 , -heteroaryl-R 9 , —C 1 -C 7 alkyl-aryl-R 9 , —C 1 -C 7 alkyl-heteroaryl -R 9 , —C 1 -C 7 alkyl-R 8 , -aryl-C 1 -C 7  alkyl-R 8 , or -heteroaryl-C 1 -C 7 alkyl-R 8 , wherein
           the aryl, heteroaryl, -alkyl-aryl, -aryl-alkyl, -alkyl-heteroaryl, and -heteroaryl-alkyl groups are optionally and independently substituted with one, two, or three groups which are each independently —O(O)R 11 , —CO(O)R 12 , —C(O)N(R 12 ) 2 , wherein
               each R 11  is independently hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or —C 1 -C 7  alkylheteroaryl; and   each R 12  is independently R 11  or a protecting group;   
               
           and   R 8  is —C(H)(COOR 3 )N(R 15 )-L 1 -(C 1 -C 7 )alkyl-R 9 ,
           —O(H)(COOR 3 )N(R  15 )-L 1 -aryl-R 9 ,   —C(H)(COOR 3 )N(R 15 )-L 1 -heteroaryl-R 9 ,   —C(H)(COOR 3 )N(R 15 )-L 1 -aryl(C 1 -C 7 )alkyl-R 9 ,   —O(H)(COOR 3 )N(R 15 )-L 1 -heteroaryl(C 1 -C 7 )alkyl-R 9 ,   —C(H)(COOR 3 )N(R 15 )-L 1 -G-CH 2 CH 2 —R 9 ,   —C(H)(COOR 3 )N(R 15 )-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 ,   or R 9 ,   wherein   R 15  is hydrogen, —C 1 -C 7  alkyl, alkylaryl, —C 1 -C 7  alkylheteroaryl, or a protecting group;   L 1  is —C(O)—, —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—; and   the aryl, heteroaryl, arylalkyl, and heteroarylalkyl groups are optionally substituted with one, two, or three groups which are each independently halomethyl dihalomethyl, trihalomethyl, —C(O)R 81 , —C(O)N(R 82 ) 2 , -, wherein
               each R 81  is independently hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or —C 1 -C 7  alkylheteroaryl; and   each R 82  is independently R 81  or a protecting group;   
               G is —(CH 2 CH 2 O) q —, wherein q is an integer from 1 to 200 (e.g., q is 100-200, 150-200, 1-100, 1-50, 1-10, or 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10);   
           
       R 9  is (1) —N 3 , —C≡CH, —ONH 2 , —C(O)N(H)NH 2 , or —N(H)NH 2 ;
               (ii) a detectable label, a cytotoxic group, or biotin;   (iii) a pendant group comprising either a detectable label, a cytotoxic group, or biotin; or   (iv) a pendant group bonded to a solid support.           
       
 
         [0056]    The invention further comprises subgenera of embodiment (1) of the first aspect in which the substituents are selected as any and all combinations of R, R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 11 , R 12 , R 15 , R 31 , R 81 , R 82 , L, L 1 , M, X, Y, in, and n, as defined herein, including without limitation, the following: 
         [0057]    R 1  in formula (I) is one of the following groups (1a)-(1l):
       (1a) —C(O)OR 3  or —C(O)N(R 3 ) 2 .   (1b) —C(O)OR 3 .   (1c) —C(O)OR 34 , wherein R 34  is hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or a protecting group.   (1d) —C(O)OR 34 , wherein R 34  is hydrogen or —C 1 -C 7  alkyl aryl.   (1e) —C(O)OR 34 , wherein R 34  is hydrogen or benzyl.   (1 f) —C(O)OR 34 , wherein R 34  is benzyl.   (1g) —C(O)OR 34 , wherein R 34  is hydrogen or a protecting group.   (1h) —C(O)OR 34 , wherein R 34  is a protecting group.   (1i) —C(O)OH.   (1j) —P(O)(OR 3 ) 2  or —OP(O)(OR 3 ) 2 .   (1k) —S(O) 2 R 3 , —S(O) 2 OR 3  or —S(O) 2 N(R 3 ) 2 .   (1l) tetrazolyl.       
 
         [0070]    R 2  in formula (1) is one of the following groups (2a)-(2j):
       (2a) —C(O)OR 3  or —C(O)N(R 3 ) 2 .   (2b) —C(O)OR 3 .   (2c) —C(O)OR 32  wherein R 32  is hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or a protecting group.   (2d) —C(O)OR 32  wherein R 32  is hydrogen or —C 1 -C 7  alkylaryl.   (2e) —C(O)OR 32  wherein R 32  is hydrogen or benzyl.   (2f) —C(O)OR 32  wherein R 32  is benzyl.   (2g) —C(O)OH.   (2h) —P(O)(OR 3 ) 2  or —OP(O)(OR 3 ) 2 .   (2i) —S(O) 2 R 3 ; —S(O) 2  OR 3  or —S(O) 2 N(R 3 ) 2 .   (2j) tetrazolyl.       
 
         [0081]    R 4  in formula (I) is one of the following groups (3a)-(3k):
       (3a) hydrogen, —C(O)OR 3 , or —C(O)N(R 3 ) 2 .   (3b) hydrogen or —C(O)OR 3 .   (3c) —C(O)OR 33  wherein R 33  is hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or a protecting group.   (3d) —C(O)OR 33  wherein R 33  is hydrogen or —C 1 -C 7  alkylaryl.   (3e) —C(O)OR 33  wherein R 33  is hydrogen or benzyl.   (3f) —C(O)OR 33  wherein R 33  is benzyl.   (3g) —C(O)OH.   (3h) —P(O)(OR 3 ) 2  or —OP(O)(OR 3 ) 2      (3i) —S(O) 2 R 3 , —S(O) 2 OR 3  or —S(O) 2 N(R 3 ) 2 .   (3j) tetrazolyl.   (3k) hydrogen.       
 
         [0093]    R 7  in formula (I) is one of the following groups (4a)-(4w):
       (4a) —C(O)R 10 .   (4h) (Pep)-C(O)R 10 .   (4c) —C(O)C 1 -C 7 alkyl-R 8 .   (4d) —C(O)C 1 -C 7 alkyl-R 8 , wherein R 8  is —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -heteroaryl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 , —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 , or —R 9 .   (4e) —C(O)C 1 -C 7 alkyl-R 8 , wherein R 8  is —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 , —C(H)(COOR 3 )N(H)-L  1 -(C  1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 , or R 9 .   (4f) —C(O)C 1 -C 7 alkylC(H)(COOR 3 )N(H)-L 1 -(C  1 -C 7 )alkyl-R 9 .   (4g) —C(O)C 1 -C 7 alkylC(H)(COOR 3 )N(H)-L 1 -heteroaryl-R 9 ,   (4h) —C(O)C 1 -C 7 alkylC(H)(COOR 3 )N(H)-L 1 -pyridyl-R 9 ,   (4i) —C(O)C 1 -C 7 alkylC(H)(COOR 3 )N(H)-L 1 -aryl-R 9 ,   (4j) —C(O)C  1 -C 7 alkylC(H)(COOR 3 )N(H)-L  1 -phenyl-R 9 ,   (4k) —C(O)C 1 -C 7 alkyl-C(H)(COOR 3 )N(H)-L 1 -G-CH 2 —R 9 .   (4l) —C(O)C 1 -C 7 alkyl-C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 .   (4m) (Pep)-C(O)C 1 -C 7 alkyl-R 8 , wherein R 8  is —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )allcyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -heteroaryl-R 9 ,—C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 , —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 , or R 9 .   (4n) (Pep)-C(O)C 1 -C 7 alkyl-R 8 , wherein R 8  is C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 ,—C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 , or R 9 .   (4o) (Pep)-C(O)—C 1 -C 7 alkylC(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 .   (4p) (Pep)-C(O)—C 1 -C 7 alkyl-C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 .   (4q) (Pep)-C(O)C 1 -C 7 alkyl-C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O-(C 1 -C 7 )alkyl-R 9 .   (4r) (Pep)-C(O)C 1 -C 7 alkyl-R 8 .   (4s) any one of groups (4d)-(4o), wherein L 1  is —C(O)—.   (4t) any one of groups (4d)-(4o), wherein L 1  is —C(O)—, —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (4u) any one of groups (4d)-(4o), wherein L 1  is —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (4v) any one of groups (4d)-(4o), wherein L 1  is —C(O)N(H)— or —C(S)N(H)—.   (4w) any one of groups (4d)-(4o), wherein L 1  is —C(O)N(H)—.       
 
         [0117]    R 8  in formula (I) is one of the following groups (5a)-(5o):
       (5a) C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -heteroaryl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 , —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )allcyl-R 9 , or —R 9 .   (5b) —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 , —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 OH 2 —R 9 , —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 , or —R 9 .   (5c) —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-R 9 .   (5d) —C(H)(COOR 3 )N(H)-L 1 -G-CH 2 CH 2 —R 9 .   (5e) —C(H)(COOR 3 )N(H)-L 1 -(C 1 -C 7 )alkyl-O—(C 1 -C 7 )alkyl-R 9 .   (5f) —C(H)(COOR 3 )N(H)-L 1 -heteroaryl-R 9 ,   (5g) —C(H)(COOR 3 )N(H)-L 1 -pyridyl-R 9 ,   (5h) —C(H)(COOR 3 )N(H)-L 1 -aryl-R 9 ,   (5i) —C(H)(COOR 3 )N(H)-L 1 -phenyl-R 9 ,   (5j) —R 9 .   (5k) any one of groups (5a)-(5g), wherein L 1  is —C(O)—.   (5l) any one of groups (5a)-(5g), wherein L 1  is —C(O)—, —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5m) any one of groups (5a)-(5g), wherein L 1  is —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5n) any one of groups (5a)-(5g), wherein is —C(O)N(H)— or —C(S)N(H)—.   (5o) any one of groups (5a)-(5g), wherein L 1  is —C(O)N(H)—.       
 
         [0133]    L in formula (I) is one of the following groups (5p)-(5u):
       (5p) —C(O)—.   (5q) -(Pep)-C(O)—.   (5r) —C(O)—, —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5s) —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5t) —C(O)N(H)— or —C(S)N(H)—.   (5u) —C(O)N(H)—.       
 
         [0140]    L 1  in formula (I) is one of the following groups (5v)-(5z):
       (5v) —C(O)—.   (5w) —C(O)—, —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5x) —C(O)N(H)—, —C(O)O—, —C(S)N(H)—, or —C(S)O—.   (5y) —C(O)N(H)— or —C(S)N(H)—.   (5z) —C(O)N(H)—.       
 
         [0146]    M in formula (I) is one of the following groups (6a)-(6e):
       (6a) —O—, —S—, or —N(R 31 )—.   (6b) —O—.   (6c) —S—.   (6) —N(R 31 )—.   (6e) —N(H)—.       
 
         [0152]    X and Y in formula (1) are one of the following groups (7a)-(7g):
       (7a) X and Y are each —O—.   (7b) X is —O— and Y is —N(R)—.   (7c) Y is —O— and X is —N(R)—.   (7d) X is —O— and Y is —N(H)—.   (7e) Y is —O— and X is —N(H)—.   (7f) X and Y are each —N(R)—.   (7g) X and Y are each —N(H)—.       
 
         [0160]    m and n in formula (1) are one of the following groups (8a)-(8g):
       (8a) m is 1, 2, 3, 4, 5, or 6 and n is 1, 2, or 3.   (8b) m is 1, 2, or 3 and n is 1, 2, 3, 4, 5, or 6.   (8c) in is 1, 2, or 3 and n is 1, 2, or 3.   (8d) in is 1 or 2 and n is 1 or 2. 1       
 
         [0165]    (8e) in is 1 or 2 and n is 1.
       (8f) m is 1 and n is 1 or 2.   (8g) m is 1 and n is 1.       
 
         [0168]    R 5  in formula (I) is one of the following groups (8h)-(8l):
       (8h) hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkyl aryl, or —C 1 -C 7  alkylheteroaryl.   (8i) hydrogen, methyl, ethyl, t-butyl, or benzyl.   (8j) hydrogen.   (8k) hydrogen or benzyl.   (8l) benzyl.       
 
         [0174]    each R 6  in formula (I) is independently one of the following groups (8m)-(8q):
       (8m) methyl or fluoro.   (8n) hydrogen, methyl, or fluoro.   (8o) hydrogen or methyl.   (8p) hydrogen or fluoro.   (8q) hydrogen.       
 
         [0180]    each of variables R, R 11 , R 12 , R 15 , R 31 , R 81 , and R 82  in formula (I) are independently selected from one of the following groups (8r)-(8v):
       (8r) hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or —C 1 -C 7  alkylheteroaryl.   (8s) hydrogen, —C 2 -C 7  alkyl, or —C 1 -C 7  alkylaryl.   (8t) hydrogen or —C 1 -C 7  alkyl.   (8u) hydrogen.   (8v) —C 1 -C 7  alkyl.       
 
         [0186]    Particular embodiments of this aspect of the invention include compounds of formula (I) wherein are defined in each of the following rows, wherein each entry is a group number as defined above for formula (I) (e.g., (8e) refers to m is 1-6, in a sub-embodiment m is 1, n is 1): 
         [0000]    
       
         
               
               
               
               
               
               
               
               
               
             
           
               
                   
               
               
                 Embodiment 
                 R 1   
                 R 2   
                 R 4   
                 R 6   
                 R 7   
                 X &amp; Y 
                 m &amp; n 
                 M 
               
               
                   
               
             
             
               
                 I-1 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-2 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-3 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-4 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-5 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-6 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-7 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-8 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-9 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-10 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-11 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-12 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-13 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-14 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-15 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-16 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-17 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-18 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-19 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-20 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-21 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-22 
                 1b 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-23 
                 1b 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-24 
                 1b 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-25 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-26 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-27 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-28 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-29 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-30 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-31 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-32 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-33 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-34 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-35 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-36 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-37 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-38 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-39 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-40 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-41 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-42 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-43 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-44 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-45 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-46 
                 1b 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-47 
                 1b 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-48 
                 1b 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-49 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-50 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-51 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-52 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-53 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-54 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-55 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-56 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-57 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-58 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-59 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-60 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-61 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-62 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-63 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-64 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-65 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-66 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-67 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-68 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-69 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-70 
                 1b 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-71 
                 1b 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-72 
                 1b 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-73 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-74 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-75 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-76 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-77 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-78 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-79 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-80 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-81 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-82 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-83 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-84 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-85 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-86 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-87 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-88 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-89 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-90 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-91 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-92 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-93 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-94 
                 1b 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-95 
                 1b 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-96 
                 1b 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-97 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-98 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-99 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-100 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-101 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-102 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-103 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-104 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-105 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-106 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-107 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-108 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-109 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-110 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-111 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-112 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-113 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-114 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-115 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-116 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-117 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-118 
                 1e 
                 2b 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-119 
                 1e 
                 2b 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-120 
                 1e 
                 2b 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-121 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-122 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-123 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-124 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-125 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-126 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-127 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-128 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-129 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-130 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-131 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-132 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-133 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-134 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-135 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-136 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-137 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-138 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-139 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-140 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-141 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-142 
                 1e 
                 2b 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-143 
                 1e 
                 2b 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-144 
                 1e 
                 2b 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-145 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-146 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-147 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-148 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-149 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-150 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-151 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-152 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-153 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-154 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-155 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-156 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-157 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-158 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-159 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-160 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-161 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-162 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-163 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-164 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-165 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-166 
                 1e 
                 2e 
                 3b 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-167 
                 1e 
                 2e 
                 3e 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-168 
                 1e 
                 2e 
                 3k 
                 8m 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-169 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-170 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-171 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-172 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-173 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-174 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-175 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-176 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-177 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-178 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-179 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-180 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-181 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-182 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-183 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-184 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-185 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-186 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-187 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-188 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-189 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-190 
                 1e 
                 2e 
                 3b 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-191 
                 1e 
                 2e 
                 3e 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-192 
                 1e 
                 2e 
                 3k 
                 8m 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-193 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-194 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-195 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-196 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-197 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-198 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-199 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-200 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-201 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-202 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-203 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-204 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-205 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-206 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-207 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-208 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-209 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-210 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-211 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-212 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-213 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-214 
                 1b 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-215 
                 1b 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-216 
                 1b 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-217 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-218 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-219 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-220 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-221 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-222 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-223 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-224 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-225 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-226 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-227 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-228 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-229 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-230 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-231 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-232 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-233 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-234 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-235 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-236 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-237 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-238 
                 1b 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-239 
                 1b 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-240 
                 1b 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-241 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-242 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-243 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-244 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-245 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-246 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-247 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-248 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-249 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-250 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-251 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-252 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-253 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-254 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-255 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-256 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-257 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-258 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-259 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-260 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-261 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-262 
                 1b 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-263 
                 1b 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-264 
                 1b 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-265 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-266 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-267 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-268 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-269 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-270 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-271 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-272 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-273 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-274 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-275 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-276 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-277 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-278 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-279 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-280 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-281 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-282 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-283 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-284 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-285 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-286 
                 1b 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-287 
                 1b 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-288 
                 1b 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-289 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-290 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-291 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-292 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-293 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-294 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-295 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-296 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-297 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-298 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-299 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-300 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-301 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-302 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-303 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-304 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-305 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-306 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-307 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-308 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-309 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-310 
                 1e 
                 2b 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-311 
                 1e 
                 2b 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-312 
                 1e 
                 2b 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-313 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-314 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-315 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-316 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-317 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-318 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-319 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-320 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-321 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-322 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-323 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-324 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-325 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-326 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-327 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-328 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-329 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-330 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-331 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-332 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-333 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-334 
                 1e 
                 2b 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-335 
                 1e 
                 2b 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-336 
                 1e 
                 2b 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-337 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-338 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-339 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6a 
               
               
                 I-340 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-341 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-342 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8c 
                 6d 
               
               
                 I-343 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-344 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-345 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6a 
               
               
                 I-346 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-347 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-348 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7a 
                 8e 
                 6d 
               
               
                 I-349 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-350 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-351 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6a 
               
               
                 I-352 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-353 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-354 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8c 
                 6d 
               
               
                 I-355 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-356 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-357 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6a 
               
               
                 I-358 
                 1e 
                 2e 
                 3b 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-359 
                 1e 
                 2e 
                 3e 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-360 
                 1e 
                 2e 
                 3k 
                 8q 
                 4d 
                 7b 
                 8e 
                 6d 
               
               
                 I-361 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-362 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-363 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6a 
               
               
                 I-364 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-365 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-366 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8c 
                 6d 
               
               
                 I-367 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-368 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-369 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6a 
               
               
                 I-370 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-371 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-372 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7a 
                 8e 
                 6d 
               
               
                 I-373 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-374 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-375 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6a 
               
               
                 I-376 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-377 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-378 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8c 
                 6d 
               
               
                 I-379 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-380 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-381 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6a 
               
               
                 I-382 
                 1e 
                 2e 
                 3b 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-383 
                 1e 
                 2e 
                 3e 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                 I-384 
                 1e 
                 2e 
                 3k 
                 8q 
                 4f 
                 7b 
                 8e 
                 6d 
               
               
                   
               
             
          
         
       
     
         [0187]    In embodiment (2) of the first aspect, the invention comprises the compound of formula (II), or any one of formulae (IIa)-(IIe), 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    and pharmaceutically acceptable salts thereof, wherein p is 0 or 1; R 26  is —C 1 -C 7 alkyl-R 9 , aryl-R 9 , aryl(C 1 -C 7 ) alkyl-R 9 , or -heteroaryl-R 9 , and m, n, X, Y, L 1 , R 1 -R 6 , R 9 , R 15 , and R 31  are as defined for formula (I). 
         [0188]    The invention further comprises subgenera of embodiment (2) of the first aspect in which the substituents are selected as any and all combinations of m, n, L 1 , R 1 , R 2 , R 4 , R 5 , R 6 , R 15 , R 20 , R 31 , X, and Y as defined herein, including without limitation, the following: 
         [0189]    R 1  is one of groups (1a)-(1l) as defined above for formula (I). 
         [0190]    R 2  is one of groups (2a)-(2j) as defined above for formula (I). 
         [0191]    R 4  is one of groups (3a)-(3k) as defined above for formula (I). 
         [0192]    R 5  is one of groups (8h)-(8l) as defined above for formula (I). 
         [0193]    each R 6  is independently one of groups (8m)-(8q) as defined above for formula (I). 
         [0194]    L 1  is one of groups (5v)-(5z) as defined above for formula (I). 
         [0195]    X and Y are one of groups (7a)-(7g) as defined above for formula (I). 
         [0196]    m and n are one of groups (8a)-(8g) as defined above for formula (I). 
         [0197]    each R 3  is independently one of the following groups (9a)-(9e):
       (9a) hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or —C 1 -C 7  alkylheteroaryl.   (9b) hydrogen, methyl, ethyl, t-butyl, or benzyl.   (9c) benzyl.   (9d) hydrogen or benzyl.   (9e) hydrogen.       
 
         [0203]    R 15  and R 31  are each independently one of the following groups (10a)-(10e):
       (10a) hydrogen, —C 1 -C 7  alkyl, or benzyl.   (10b) hydrogen or —C 1 -C7 alkyl.   (10c) hydrogen or methyl.   (10d) hydrogen.   (10e) methyl       
 
         [0209]    R 20  is one of the following groups (11a) (11gg):
       (11a) R 20  is —C 1 -C 7 alkyl-R 9 , -aryl(C 1 -C 7 ) alkyl-R 9 , or -heteroaryl-R 9 .   (11b) R 20  is —C 1 -C 7 alkyl-R 9  or -aryl(C 1 -C 7 ) alkyl-R 9 .   (11e) R 20  is -heteroaryl-R 9 .   (11d) R 20  is -pyridyl-R 9 .   (11e) R 20  is -pyrimiclinyl-R 9 .   (11f) R 20  is —C 1 -C 7 alkyl-R 9 .   (11g) R 20  is —C 1 -C 7 alkyl-R 9 , -aryl(C 1 -C 7 ) alkyl-R 9 , or -heteroaryl-R 9 .   (11h) R 20  is —C 1 -C 7 alkyl-R 9 .   (11i) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein Z 1  is a fluoro cold standard and t is 0, 1, 2, 3, 4, or 5.
       (11j) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein Z 1  is a fluoro cold standard.
       (11k) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein Z 2  is fluoro cold standard, .
       (11l) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11m)
 
wherein Z 2  is a fluoro cold standard. R 20  is selected from the goup consisting of,
 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein t is 0, 1, 2, 3, 4, or 5.
       (11n) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0224]    wherein t is 0, 1, 2, 3, 4, or 5.
       (11o) R 20  is selected from the group consisting of,       
 
         [0000]    
       
                 
         
             
             
         
       
     
         [0226]    (11p) R 20  is selected from the group consisting of, 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11q) R 20  is 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    wherein t is 0, 1, 2, 3, 4, or 5.
       (11r) R 20  is       
 
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11s) R 20  is 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11t) R 20  is 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11u) R 20  is 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
       
         
           
             (11v) R 20  is 
           
         
       
     
         [0000]    
       
                 
         
             
             
         
       
     
         [0233]    Particular embodiments of this aspect of the invention include compounds of any one of formulae (II) and (IIa)-(IIe) wherein are defined in each of the following rows, wherein each entry is a group number as defined above: 
         [0000]    
       
         
               
               
               
               
               
               
               
             
           
               
                   
               
               
                 Embodiment 
                 R 1 , R 2 , R 4 , R 5   
                 R 3   
                 R 6   
                 L 1   
                 R 20   
                 R 31   
               
               
                   
               
             
             
               
                 II-1 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11a 
                 10c 
               
               
                 II-2 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11b 
                 10c 
               
               
                 II-3 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11c 
                 10c 
               
               
                 II-4 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11d 
                 10c 
               
               
                 II-5 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11e 
                 10c 
               
               
                 II-6 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11f 
                 10c 
               
               
                 II-7 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11g 
                 10c 
               
               
                 II-8 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11h 
                 10c 
               
               
                 II-9 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11i 
                 10c 
               
               
                 II-10 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11j 
                 10c 
               
               
                 II-11 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11k 
                 10c 
               
               
                 II-12 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11l 
                 10c 
               
               
                 II-13 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11m 
                 10c 
               
               
                 II-14 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11n 
                 10c 
               
               
                 II-15 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11o 
                 10c 
               
               
                 II-16 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11p 
                 10c 
               
               
                 II-17 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11q 
                 10c 
               
               
                 II-18 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11r 
                 10c 
               
               
                 II-19 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11s 
                 10c 
               
               
                 II-20 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11t 
                 10c 
               
               
                 II-21 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11u 
                 10c 
               
               
                 II-22 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11v 
                 10c 
               
               
                 II-23 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11w 
                 10c 
               
               
                 II-24 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11x 
                 10c 
               
               
                 II-25 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11y 
                 10c 
               
               
                 II-26 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11z 
                 10c 
               
               
                 II-27 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11aa 
                 10c 
               
               
                 II-28 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11bb 
                 10c 
               
               
                 II-29 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11cc 
                 10c 
               
               
                 II-30 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11dd 
                 10c 
               
               
                 II-31 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11ee 
                 10c 
               
               
                 II-32 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11ff 
                 10c 
               
               
                 II-33 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5v 
                 11gg 
                 10c 
               
               
                 II-34 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11a 
                 10c 
               
               
                 II-35 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11b 
                 10c 
               
               
                 II-36 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11c 
                 10c 
               
               
                 II-37 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11d 
                 10c 
               
               
                 II-38 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11e 
                 10c 
               
               
                 II-39 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11f 
                 10c 
               
               
                 II-40 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11g 
                 10c 
               
               
                 II-41 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11h 
                 10c 
               
               
                 II-42 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11i 
                 10c 
               
               
                 II-43 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11j 
                 10c 
               
               
                 II-44 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11k 
                 10c 
               
               
                 II-45 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11l 
                 10c 
               
               
                 II-46 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11m 
                 10c 
               
               
                 II-47 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11n 
                 10c 
               
               
                 II-48 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11o 
                 10c 
               
               
                 II-49 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11p 
                 10c 
               
               
                 II-50 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11q 
                 10c 
               
               
                 II-51 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11r 
                 10c 
               
               
                 II-52 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11s 
                 10c 
               
               
                 II-53 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11t 
                 10c 
               
               
                 II-54 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11u 
                 10c 
               
               
                 II-55 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11v 
                 10c 
               
               
                 II-56 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11w 
                 10c 
               
               
                 II-57 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11x 
                 10c 
               
               
                 II-58 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11y 
                 10c 
               
               
                 II-59 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11z 
                 10c 
               
               
                 II-60 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11aa 
                 10c 
               
               
                 II-61 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11bb 
                 10c 
               
               
                 II-62 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11cc 
                 10c 
               
               
                 II-63 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11dd 
                 10c 
               
               
                 II-64 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11ee 
                 10c 
               
               
                 II-65 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11ff 
                 10c 
               
               
                 II-66 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5v 
                 11gg 
                 10c 
               
               
                 II-67 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11a 
                 10c 
               
               
                 II-68 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11b 
                 10c 
               
               
                 II-69 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11c 
                 10c 
               
               
                 II-70 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11d 
                 10c 
               
               
                 II-71 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11e 
                 10c 
               
               
                 II-72 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11f 
                 10c 
               
               
                 II-73 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11g 
                 10c 
               
               
                 II-74 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11h 
                 10c 
               
               
                 II-75 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11i 
                 10c 
               
               
                 II-76 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11j 
                 10c 
               
               
                 II-77 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11k 
                 10c 
               
               
                 II-78 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11l 
                 10c 
               
               
                 II-79 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11m 
                 10c 
               
               
                 II-80 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11n 
                 10c 
               
               
                 II-81 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11o 
                 10c 
               
               
                 II-82 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11p 
                 10c 
               
               
                 II-83 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11q 
                 10c 
               
               
                 II-84 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11r 
                 10c 
               
               
                 II-85 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11s 
                 10c 
               
               
                 II-86 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11t 
                 10c 
               
               
                 II-87 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11u 
                 10c 
               
               
                 II-88 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11v 
                 10c 
               
               
                 II-89 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11w 
                 10c 
               
               
                 II-90 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11x 
                 10c 
               
               
                 II-91 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11y 
                 10c 
               
               
                 II-92 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11z 
                 10c 
               
               
                 II-93 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11aa 
                 10c 
               
               
                 II-94 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11bb 
                 10c 
               
               
                 II-95 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11cc 
                 10c 
               
               
                 II-96 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11dd 
                 10c 
               
               
                 II-97 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11ee 
                 10c 
               
               
                 II-98 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11ff 
                 10c 
               
               
                 II-99 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5v 
                 11gg 
                 10c 
               
               
                 II-100 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11a 
                 10c 
               
               
                 II-101 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11b 
                 10c 
               
               
                 II-102 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11c 
                 10c 
               
               
                 II-103 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11d 
                 10c 
               
               
                 II-104 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11e 
                 10c 
               
               
                 II-105 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11f 
                 10c 
               
               
                 II-106 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11g 
                 10c 
               
               
                 II-107 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11h 
                 10c 
               
               
                 II-108 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11i 
                 10c 
               
               
                 II-109 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11j 
                 10c 
               
               
                 II-110 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11k 
                 110c 
               
               
                 II-111 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11l 
                 10c 
               
               
                 II-112 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11m 
                 10c 
               
               
                 II-113 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11n 
                 10c 
               
               
                 II-114 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11o 
                 10c 
               
               
                 II-115 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11p 
                 10c 
               
               
                 II-116 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11q 
                 10c 
               
               
                 II-117 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11r 
                 10c 
               
               
                 II-118 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11s 
                 10c 
               
               
                 II-119 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11t 
                 10c 
               
               
                 II-120 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11u 
                 10c 
               
               
                 II-121 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11v 
                 10c 
               
               
                 II-122 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11w 
                 10c 
               
               
                 II-123 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11x 
                 10c 
               
               
                 II-124 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11y 
                 10c 
               
               
                 II-125 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11z 
                 10c 
               
               
                 II-126 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11aa 
                 10c 
               
               
                 II-127 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11bb 
                 10c 
               
               
                 II-128 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11cc 
                 10c 
               
               
                 II-129 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11dd 
                 10c 
               
               
                 II-130 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11ee 
                 10c 
               
               
                 II-131 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11ff 
                 10c 
               
               
                 II-132 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5v 
                 11gg 
                 10c 
               
               
                 II-133 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11a 
                 10c 
               
               
                 II-134 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11b 
                 10c 
               
               
                 II-135 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11c 
                 10c 
               
               
                 II-136 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11d 
                 10c 
               
               
                 II-137 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11e 
                 10c 
               
               
                 II-138 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11f 
                 10c 
               
               
                 II-139 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11g 
                 10c 
               
               
                 II-140 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11h 
                 10c 
               
               
                 II-141 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11i 
                 10c 
               
               
                 II-142 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11j 
                 10c 
               
               
                 II-143 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11k 
                 10c 
               
               
                 II-144 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11l 
                 10c 
               
               
                 II-145 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11m 
                 10c 
               
               
                 II-146 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11n 
                 10c 
               
               
                 II-147 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11o 
                 10c 
               
               
                 II-148 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11p 
                 10c 
               
               
                 II-149 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11q 
                 10c 
               
               
                 II-150 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11r 
                 10c 
               
               
                 II-151 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11s 
                 10c 
               
               
                 II-152 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11t 
                 10c 
               
               
                 II-153 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11u 
                 10c 
               
               
                 II-154 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11v 
                 10c 
               
               
                 II-155 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11w 
                 10c 
               
               
                 II-156 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11x 
                 10c 
               
               
                 II-157 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11y 
                 10c 
               
               
                 II-158 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11z 
                 10c 
               
               
                 II-159 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11aa 
                 10c 
               
               
                 II-160 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11bb 
                 10c 
               
               
                 II-161 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11cc 
                 10c 
               
               
                 II-162 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11dd 
                 10c 
               
               
                 II-163 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11ee 
                 10c 
               
               
                 II-164 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11ff 
                 10c 
               
               
                 II-165 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5v 
                 11gg 
                 10c 
               
               
                 II-166 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11a 
                 10c 
               
               
                 II-167 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11b 
                 10c 
               
               
                 II-168 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11c 
                 10c 
               
               
                 II-169 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11d 
                 10c 
               
               
                 II-170 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11e 
                 10c 
               
               
                 II-171 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11f 
                 10c 
               
               
                 II-172 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11g 
                 10c 
               
               
                 II-173 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11h 
                 10c 
               
               
                 II-174 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11i 
                 10c 
               
               
                 II-175 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11j 
                 10c 
               
               
                 II-176 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11k 
                 10c 
               
               
                 II-177 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11l 
                 10c 
               
               
                 II-178 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11m 
                 10c 
               
               
                 II-179 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11n 
                 10c 
               
               
                 II-180 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11o 
                 10c 
               
               
                 II-181 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11p 
                 10c 
               
               
                 II-182 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11q 
                 10c 
               
               
                 II-183 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11r 
                 10c 
               
               
                 II-184 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11s 
                 10c 
               
               
                 II-185 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11t 
                 10c 
               
               
                 II-186 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11u 
                 10c 
               
               
                 II-187 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11v 
                 10c 
               
               
                 II-188 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11w 
                 10c 
               
               
                 II-189 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11x 
                 10c 
               
               
                 II-190 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11y 
                 10c 
               
               
                 II-191 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11z 
                 10c 
               
               
                 II-192 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11aa 
                 10c 
               
               
                 II-193 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11bb 
                 10c 
               
               
                 II-194 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11cc 
                 10c 
               
               
                 II-195 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11dd 
                 10c 
               
               
                 II-196 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11ee 
                 10c 
               
               
                 II-197 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11ff 
                 10c 
               
               
                 II-198 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5v 
                 11gg 
                 10c 
               
               
                 II-199 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11a 
                 10c 
               
               
                 II-200 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11b 
                 10c 
               
               
                 II-201 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11c 
                 10c 
               
               
                 II-202 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11d 
                 10c 
               
               
                 II-203 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11e 
                 10c 
               
               
                 II-204 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11f 
                 10c 
               
               
                 II-205 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11g 
                 10c 
               
               
                 II-206 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11h 
                 10c 
               
               
                 II-207 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11i 
                 10c 
               
               
                 II-208 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11j 
                 10c 
               
               
                 II-209 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11k 
                 10c 
               
               
                 II-210 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11l 
                 10c 
               
               
                 II-211 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11m 
                 10c 
               
               
                 II-212 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11n 
                 10c 
               
               
                 II-213 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11o 
                 10c 
               
               
                 II-214 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11p 
                 10c 
               
               
                 II-215 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11q 
                 10c 
               
               
                 II-216 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11r 
                 10c 
               
               
                 II-217 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11s 
                 10c 
               
               
                 II-218 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11t 
                 10c 
               
               
                 II-219 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11u 
                 10c 
               
               
                 II-220 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11v 
                 10c 
               
               
                 II-221 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11w 
                 10c 
               
               
                 II-222 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11x 
                 10c 
               
               
                 II-223 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11y 
                 10c 
               
               
                 II-224 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11z 
                 10c 
               
               
                 II-225 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11aa 
                 10c 
               
               
                 II-226 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11bb 
                 10c 
               
               
                 II-227 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11cc 
                 10c 
               
               
                 II-228 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11dd 
                 10c 
               
               
                 II-229 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11ee 
                 10c 
               
               
                 II-230 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11ff 
                 10c 
               
               
                 II-231 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5v 
                 11gg 
                 10c 
               
               
                 II-232 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11a 
                 10c 
               
               
                 II-233 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11b 
                 10c 
               
               
                 II-234 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11c 
                 10c 
               
               
                 II-235 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11d 
                 10c 
               
               
                 II-236 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11e 
                 10c 
               
               
                 II-237 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11f 
                 10c 
               
               
                 II-238 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11g 
                 10c 
               
               
                 II-239 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11h 
                 10c 
               
               
                 II-240 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11i 
                 10c 
               
               
                 II-241 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11j 
                 10c 
               
               
                 II-242 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11k 
                 10c 
               
               
                 II-243 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11l 
                 10c 
               
               
                 II-244 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11m 
                 10c 
               
               
                 II-245 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11n 
                 10c 
               
               
                 II-246 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11o 
                 10c 
               
               
                 II-247 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11p 
                 10c 
               
               
                 II-248 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11q 
                 10c 
               
               
                 II-249 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11r 
                 10c 
               
               
                 II-250 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11s 
                 10c 
               
               
                 II-251 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11t 
                 10c 
               
               
                 II-252 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11u 
                 10c 
               
               
                 II-253 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11v 
                 10c 
               
               
                 II-254 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11w 
                 10c 
               
               
                 II-255 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11x 
                 10c 
               
               
                 II-256 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11y 
                 10c 
               
               
                 II-257 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11z 
                 10c 
               
               
                 II-258 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11aa 
                 10c 
               
               
                 II-259 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11bb 
                 10c 
               
               
                 II-260 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11cc 
                 10c 
               
               
                 II-261 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11dd 
                 10c 
               
               
                 II-262 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11ee 
                 10c 
               
               
                 II-263 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11ff 
                 10c 
               
               
                 II-264 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5v 
                 11gg 
                 10c 
               
               
                 II-265 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11a 
                 10c 
               
               
                 II-266 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11b 
                 10c 
               
               
                 II-267 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11c 
                 10c 
               
               
                 II-268 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11d 
                 10c 
               
               
                 II-269 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11e 
                 10c 
               
               
                 II-270 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11f 
                 10c 
               
               
                 II-271 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11g 
                 10c 
               
               
                 II-272 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11h 
                 10c 
               
               
                 II-273 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11i 
                 10c 
               
               
                 II-274 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11j 
                 10c 
               
               
                 II-275 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11k 
                 10c 
               
               
                 II-276 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11l 
                 10c 
               
               
                 II-277 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11m 
                 10c 
               
               
                 II-278 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11n 
                 10c 
               
               
                 II-279 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11o 
                 10c 
               
               
                 II-280 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11p 
                 10c 
               
               
                 II-281 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11q 
                 10c 
               
               
                 II-282 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11r 
                 10c 
               
               
                 II-283 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11s 
                 10c 
               
               
                 II-284 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11t 
                 10c 
               
               
                 II-285 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11u 
                 10c 
               
               
                 II-286 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11v 
                 10c 
               
               
                 II-287 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11w 
                 10c 
               
               
                 II-288 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11x 
                 10c 
               
               
                 II-289 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11y 
                 10c 
               
               
                 II-290 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11z 
                 10c 
               
               
                 II-291 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11aa 
                 10c 
               
               
                 II-292 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11bb 
                 10c 
               
               
                 II-293 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11cc 
                 10c 
               
               
                 II-294 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11dd 
                 10c 
               
               
                 II-295 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11ee 
                 10c 
               
               
                 II-296 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11ff 
                 10c 
               
               
                 II-297 
                 1b, 2b, 3b, 8h 
                 9a 
                 8m 
                 5y 
                 11gg 
                 10c 
               
               
                 II-298 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11a 
                 10c 
               
               
                 II-299 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11b 
                 10c 
               
               
                 II-300 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11c 
                 10c 
               
               
                 II-301 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11d 
                 10c 
               
               
                 II-302 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11e 
                 10c 
               
               
                 II-303 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11f 
                 10c 
               
               
                 II-304 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11g 
                 10c 
               
               
                 II-305 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11h 
                 10c 
               
               
                 II-306 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11i 
                 10c 
               
               
                 II-307 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11j 
                 10c 
               
               
                 II-308 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11k 
                 10c 
               
               
                 II-309 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11l 
                 10c 
               
               
                 II-310 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11m 
                 10c 
               
               
                 II-311 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11n 
                 10c 
               
               
                 II-312 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11o 
                 10c 
               
               
                 II-313 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11p 
                 10c 
               
               
                 II-314 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11q 
                 10c 
               
               
                 II-315 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11r 
                 10c 
               
               
                 II-316 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11s 
                 10c 
               
               
                 II-317 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11t 
                 10c 
               
               
                 II-318 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11u 
                 10c 
               
               
                 II-319 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11v 
                 10c 
               
               
                 II-320 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11w 
                 10c 
               
               
                 II-321 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11x 
                 10c 
               
               
                 II-322 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11y 
                 10c 
               
               
                 II-323 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11z 
                 10c 
               
               
                 II-324 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11aa 
                 10c 
               
               
                 II-325 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11bb 
                 10c 
               
               
                 II-326 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11cc 
                 10c 
               
               
                 II-327 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11dd 
                 10c 
               
               
                 II-328 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11ee 
                 10c 
               
               
                 II-329 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11ff 
                 10c 
               
               
                 II-330 
                 1b, 2b, 3b, 8h 
                 9a 
                 8q 
                 5y 
                 11gg 
                 10c 
               
               
                 II-331 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11a 
                 10c 
               
               
                 II-332 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11b 
                 10c 
               
               
                 II-333 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11c 
                 10c 
               
               
                 II-334 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11d 
                 10c 
               
               
                 II-335 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11e 
                 10c 
               
               
                 II-336 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11f 
                 10c 
               
               
                 II-337 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11g 
                 10c 
               
               
                 II-338 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11h 
                 10c 
               
               
                 II-339 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11i 
                 10c 
               
               
                 II-340 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11j 
                 10c 
               
               
                 II-341 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11k 
                 10c 
               
               
                 II-342 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11l 
                 10c 
               
               
                 II-343 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11m 
                 10c 
               
               
                 II-344 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11n 
                 10c 
               
               
                 II-345 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11o 
                 10c 
               
               
                 II-346 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11p 
                 10c 
               
               
                 II-347 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11q 
                 10c 
               
               
                 II-348 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11r 
                 10c 
               
               
                 II-349 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11s 
                 10c 
               
               
                 II-350 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11t 
                 10c 
               
               
                 II-351 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11u 
                 10c 
               
               
                 II-352 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11v 
                 10c 
               
               
                 II-353 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11w 
                 10c 
               
               
                 II-354 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11x 
                 10c 
               
               
                 II-355 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11y 
                 10c 
               
               
                 II-356 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11z 
                 10c 
               
               
                 II-357 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11aa 
                 10c 
               
               
                 II-358 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11bb 
                 10c 
               
               
                 II-359 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11cc 
                 10c 
               
               
                 II-360 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11dd 
                 10c 
               
               
                 II-361 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11ee 
                 10c 
               
               
                 II-362 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11ff 
                 10c 
               
               
                 II-363 
                 1b, 2b, 3b, 8h 
                 9d 
                 8m 
                 5y 
                 11gg 
                 10c 
               
               
                 II-364 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11a 
                 10c 
               
               
                 II-365 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11b 
                 10c 
               
               
                 II-366 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11c 
                 10c 
               
               
                 II-367 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11d 
                 10c 
               
               
                 II-368 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11e 
                 10c 
               
               
                 II-369 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11f 
                 10c 
               
               
                 II-370 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11g 
                 10c 
               
               
                 II-371 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11h 
                 10c 
               
               
                 II-372 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11i 
                 10c 
               
               
                 II-373 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11j 
                 10c 
               
               
                 II-374 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11k 
                 10c 
               
               
                 II-375 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11l 
                 10c 
               
               
                 II-376 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11m 
                 10c 
               
               
                 II-377 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11n 
                 10c 
               
               
                 II-378 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11o 
                 10c 
               
               
                 II-379 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11p 
                 10c 
               
               
                 II-380 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11q 
                 10c 
               
               
                 II-381 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11r 
                 10c 
               
               
                 II-382 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11s 
                 10c 
               
               
                 II-383 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11t 
                 10c 
               
               
                 II-384 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11u 
                 10c 
               
               
                 II-385 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11v 
                 10c 
               
               
                 II-386 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11w 
                 10c 
               
               
                 II-387 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11x 
                 10c 
               
               
                 II-388 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11y 
                 10c 
               
               
                 II-389 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11z 
                 10c 
               
               
                 II-390 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11aa 
                 10c 
               
               
                 II-391 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11bb 
                 10c 
               
               
                 II-392 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11cc 
                 10c 
               
               
                 II-393 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11dd 
                 10c 
               
               
                 II-394 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11ee 
                 10c 
               
               
                 II-395 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11ff 
                 10c 
               
               
                 II-396 
                 1b, 2b, 3b, 8h 
                 9d 
                 8q 
                 5y 
                 11gg 
                 10c 
               
               
                 II-397 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11a 
                 10c 
               
               
                 II-398 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11b 
                 10c 
               
               
                 II-399 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11c 
                 10c 
               
               
                 II-400 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11d 
                 10c 
               
               
                 II-401 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11e 
                 10c 
               
               
                 II-402 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11f 
                 10c 
               
               
                 II-403 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11g 
                 10c 
               
               
                 II-404 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11h 
                 10c 
               
               
                 II-405 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11i 
                 10c 
               
               
                 II-406 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11j 
                 10c 
               
               
                 II-407 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11k 
                 10c 
               
               
                 II-408 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11l 
                 10c 
               
               
                 II-409 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11m 
                 10c 
               
               
                 II-410 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11n 
                 10c 
               
               
                 II-411 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11o 
                 10c 
               
               
                 II-412 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11p 
                 10c 
               
               
                 II-413 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11q 
                 10c 
               
               
                 II-414 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11r 
                 10c 
               
               
                 II-415 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11s 
                 10c 
               
               
                 II-416 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11t 
                 10c 
               
               
                 II-417 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11u 
                 10c 
               
               
                 II-418 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11v 
                 10c 
               
               
                 II-419 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11w 
                 10c 
               
               
                 II-420 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11x 
                 10c 
               
               
                 II-421 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11y 
                 10c 
               
               
                 II-422 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11z 
                 10c 
               
               
                 II-423 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11aa 
                 10c 
               
               
                 II-424 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11bb 
                 10c 
               
               
                 II-425 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11cc 
                 10c 
               
               
                 II-426 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11dd 
                 10c 
               
               
                 II-427 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11ee 
                 10c 
               
               
                 II-428 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11ff 
                 10c 
               
               
                 II-429 
                 1e, 2e, 3e, 8k 
                 9a 
                 8m 
                 5y 
                 11gg 
                 10c 
               
               
                 II-430 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11a 
                 10c 
               
               
                 II-431 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11b 
                 10c 
               
               
                 II-432 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11c 
                 10c 
               
               
                 II-433 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11d 
                 10c 
               
               
                 II-434 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11e 
                 10c 
               
               
                 II-435 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11f 
                 10c 
               
               
                 II-436 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11g 
                 10c 
               
               
                 II-437 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11h 
                 10c 
               
               
                 II-438 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11i 
                 10c 
               
               
                 II-439 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11j 
                 10c 
               
               
                 II-440 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11k 
                 10c 
               
               
                 II-441 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11l 
                 10c 
               
               
                 II-442 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11m 
                 10c 
               
               
                 II-443 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11n 
                 10c 
               
               
                 II-444 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11o 
                 10c 
               
               
                 II-445 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11p 
                 10c 
               
               
                 II-446 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11q 
                 10c 
               
               
                 II-447 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11r 
                 10c 
               
               
                 II-448 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11s 
                 10c 
               
               
                 II-449 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11t 
                 10c 
               
               
                 II-450 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11u 
                 10c 
               
               
                 II-451 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11v 
                 10c 
               
               
                 II-452 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11w 
                 10c 
               
               
                 II-453 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11x 
                 10c 
               
               
                 II-454 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11y 
                 10c 
               
               
                 II-455 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11z 
                 10c 
               
               
                 II-456 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11aa 
                 10c 
               
               
                 II-457 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11bb 
                 10c 
               
               
                 II-458 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11cc 
                 10c 
               
               
                 II-459 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11dd 
                 10c 
               
               
                 II-460 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11ee 
                 10c 
               
               
                 II-461 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11ff 
                 10c 
               
               
                 II-462 
                 1e, 2e, 3e, 8k 
                 9a 
                 8q 
                 5y 
                 11gg 
                 10c 
               
               
                 II-463 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11a 
                 10c 
               
               
                 II-464 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11b 
                 10c 
               
               
                 II-465 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11c 
                 10c 
               
               
                 II-466 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11d 
                 10c 
               
               
                 II-467 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11e 
                 10c 
               
               
                 II-468 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11f 
                 10c 
               
               
                 II-469 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11g 
                 10c 
               
               
                 II-470 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11h 
                 10c 
               
               
                 II-471 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11i 
                 10c 
               
               
                 II-472 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11j 
                 10c 
               
               
                 II-473 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11k 
                 10c 
               
               
                 II-474 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11l 
                 10c 
               
               
                 II-475 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11m 
                 10c 
               
               
                 II-476 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11n 
                 10c 
               
               
                 II-477 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11o 
                 10c 
               
               
                 II-478 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11p 
                 10c 
               
               
                 II-479 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11q 
                 10c 
               
               
                 II-480 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11r 
                 10c 
               
               
                 II-481 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11s 
                 10c 
               
               
                 II-482 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11t 
                 10c 
               
               
                 II-483 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11u 
                 10c 
               
               
                 II-484 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11v 
                 10c 
               
               
                 II-485 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11w 
                 10c 
               
               
                 II-486 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11x 
                 10c 
               
               
                 II-487 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11y 
                 10c 
               
               
                 II-488 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11z 
                 10c 
               
               
                 II-489 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11aa 
                 10c 
               
               
                 II-490 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11bb 
                 10c 
               
               
                 II-491 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11cc 
                 10c 
               
               
                 II-492 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11dd 
                 10c 
               
               
                 II-493 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11ee 
                 10c 
               
               
                 II-494 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11ff 
                 10c 
               
               
                 II-495 
                 1e, 2e, 3e, 8k 
                 9d 
                 8m 
                 5y 
                 11gg 
                 10c 
               
               
                 II-496 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11a 
                 10c 
               
               
                 II-497 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11b 
                 10c 
               
               
                 II-498 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11c 
                 10c 
               
               
                 II-499 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11d 
                 10c 
               
               
                 II-500 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11e 
                 10c 
               
               
                 II-501 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11f 
                 10c 
               
               
                 II-502 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11g 
                 10c 
               
               
                 II-503 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11h 
                 10c 
               
               
                 II-504 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11i 
                 10c 
               
               
                 II-505 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11j 
                 10c 
               
               
                 II-506 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11k 
                 10c 
               
               
                 II-507 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11l 
                 10c 
               
               
                 II-508 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11m 
                 10c 
               
               
                 II-509 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11n 
                 10c 
               
               
                 II-510 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11o 
                 10c 
               
               
                 II-511 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11p 
                 10c 
               
               
                 II-512 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11q 
                 10c 
               
               
                 II-513 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11r 
                 10c 
               
               
                 II-514 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11s 
                 10c 
               
               
                 II-515 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11t 
                 10c 
               
               
                 II-516 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11u 
                 10c 
               
               
                 II-517 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11v 
                 10c 
               
               
                 II-518 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11w 
                 10c 
               
               
                 II-519 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11x 
                 10c 
               
               
                 II-520 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11y 
                 10c 
               
               
                 II-521 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11z 
                 10c 
               
               
                 II-522 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11aa 
                 10c 
               
               
                 II-523 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11bb 
                 10c 
               
               
                 II-524 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11cc 
                 10c 
               
               
                 II-525 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11dd 
                 10c 
               
               
                 II-526 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11ee 
                 10c 
               
               
                 II-527 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11ff 
                 10c 
               
               
                 II-528 
                 1e, 2e, 3e, 8k 
                 9d 
                 8q 
                 5y 
                 11gg 
                 10c 
               
               
                   
               
             
          
         
       
     
         [0234]    In embodiment (3) of the first aspect, the invention comprises the compound of formula (III), or any one of (IIIa)-(IIIe), 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    and pharmaceutically acceptable salts thereof, wherein p is 0 or 1; R 20  is —C 1 -C 7 alkyl-R 9 , -aryl-R 9 , aryl(C 1 -C 7 )alkyl-R 9 , or -heteroaryl-R 9 , and R 3 , R 5 , R 6 , R 9 , R 31 , L 1 , X and Y are as defined for formula (I). 
         [0235]    The invention further comprises subgenera of embodiment (3) of the first aspect in which the substituents are selected as any and all combinations of R 3 , R 5 , R 6 , R 20 , R 31 , L 1 , X, and Y as defined herein, including without limitation, the following: 
         [0236]    each R 3  is independently one of groups (9a)-(9e) as defined above for formula (II). 
         [0237]    R 5  is one of groups (8h)-(8l) as defined above for formula (I). 
         [0238]    each R 6  is independently one of groups (8m)-(8q) as defined above for forniula. (I). 
         [0239]    R 20  is one of groups (11a)-(1 1 gg) as defined above for formula (II). 
         [0240]    R 31  is one of groups (10a)-(10e) as defined above for formula (II). 
         [0241]    L 1  is one of groups (5v)-(5z) as defined above for formula (I). 
         [0242]    X and Y are one of groups (7a)-(7g) as defined above for formula (I). 
         [0243]    Particular embodiments of this embodiment of the invention include compounds of any one of formulae (III) and (IlIa)-(IIIe) wherein are defined in each of the following rows, wherein each entry is a group number as defined above: 
         [0000]    
       
         
               
               
               
               
               
               
               
             
           
               
                   
                   
               
               
                   
                 Embodiment 
                 R 3  &amp; R 5   
                 R 6   
                 R 20   
                 R 31   
                 L 1   
               
               
                   
                   
               
             
             
               
                   
                 III-1 
                 9a, 8h 
                 8m 
                 11a 
                 10c 
                 5v 
               
               
                   
                 III-2 
                 9a, 8h 
                 8m 
                 11b 
                 10c 
                 5v 
               
               
                   
                 III-3 
                 9a, 8h 
                 8m 
                 11c 
                 10c 
                 5v 
               
               
                   
                 III-4 
                 9a, 8h 
                 8m 
                 11d 
                 10c 
                 5v 
               
               
                   
                 III-5 
                 9a, 8h 
                 8m 
                 11e 
                 10c 
                 5v 
               
               
                   
                 III-6 
                 9a, 8h 
                 8m 
                 11f 
                 10c 
                 5v 
               
               
                   
                 III-7 
                 9a, 8h 
                 8m 
                 11g 
                 10c 
                 5v 
               
               
                   
                 III-8 
                 9a, 8h 
                 8m 
                 11h 
                 10c 
                 5v 
               
               
                   
                 III-9 
                 9a, 8h 
                 8m 
                 11i 
                 10c 
                 5v 
               
               
                   
                 III-10 
                 9a, 8h 
                 8m 
                 11j 
                 10c 
                 5v 
               
               
                   
                 III-11 
                 9a, 8h 
                 8m 
                 11k 
                 10c 
                 5v 
               
               
                   
                 III-12 
                 9a, 8h 
                 8m 
                 11l 
                 10c 
                 5v 
               
               
                   
                 III-13 
                 9a, 8h 
                 8m 
                 11m 
                 10c 
                 5v 
               
               
                   
                 III-14 
                 9a, 8h 
                 8m 
                 11n 
                 10c 
                 5v 
               
               
                   
                 III-15 
                 9a, 8h 
                 8m 
                 11o 
                 10c 
                 5v 
               
               
                   
                 III-16 
                 9a, 8h 
                 8m 
                 11p 
                 10c 
                 5v 
               
               
                   
                 III-17 
                 9a, 8h 
                 8m 
                 11q 
                 10c 
                 5v 
               
               
                   
                 III-18 
                 9a, 8h 
                 8m 
                 11r 
                 10c 
                 5v 
               
               
                   
                 III-19 
                 9a, 8h 
                 8m 
                 11s 
                 10c 
                 5v 
               
               
                   
                 III-20 
                 9a, 8h 
                 8m 
                 11t 
                 10c 
                 5v 
               
               
                   
                 III-21 
                 9a, 8h 
                 8m 
                 11u 
                 10c 
                 5v 
               
               
                   
                 III-22 
                 9a, 8h 
                 8m 
                 11v 
                 10c 
                 5v 
               
               
                   
                 III-23 
                 9a, 8h 
                 8m 
                 11w 
                 10c 
                 5v 
               
               
                   
                 III-24 
                 9a, 8h 
                 8m 
                 11x 
                 10c 
                 5v 
               
               
                   
                 III-25 
                 9a, 8h 
                 8m 
                 11y 
                 10c 
                 5v 
               
               
                   
                 III-26 
                 9a, 8h 
                 8m 
                 11z 
                 10c 
                 5v 
               
               
                   
                 III-27 
                 9a, 8h 
                 8m 
                 11aa 
                 10c 
                 5v 
               
               
                   
                 III-28 
                 9a, 8h 
                 8m 
                 11bb 
                 10c 
                 5v 
               
               
                   
                 III-29 
                 9a, 8h 
                 8m 
                 11cc 
                 10c 
                 5v 
               
               
                   
                 III-30 
                 9a, 8h 
                 8m 
                 11dd 
                 10c 
                 5v 
               
               
                   
                 III-31 
                 9a, 8h 
                 8m 
                 11ee 
                 10c 
                 5v 
               
               
                   
                 III-32 
                 9a, 8h 
                 8m 
                 11ff 
                 10c 
                 5v 
               
               
                   
                 III-33 
                 9a, 8h 
                 8m 
                 11gg 
                 10c 
                 5v 
               
               
                   
                 III-34 
                 9a, 8h 
                 8q 
                 11a 
                 10c 
                 5v 
               
               
                   
                 III-35 
                 9a, 8h 
                 8q 
                 11b 
                 10c 
                 5v 
               
               
                   
                 III-36 
                 9a, 8h 
                 8q 
                 11c 
                 10c 
                 5v 
               
               
                   
                 III-37 
                 9a, 8h 
                 8q 
                 11d 
                 10c 
                 5v 
               
               
                   
                 III-38 
                 9a, 8h 
                 8q 
                 11e 
                 10c 
                 5v 
               
               
                   
                 III-39 
                 9a, 8h 
                 8q 
                 11f 
                 10c 
                 5v 
               
               
                   
                 III-40 
                 9a, 8h 
                 8q 
                 11g 
                 10c 
                 5v 
               
               
                   
                 III-41 
                 9a, 8h 
                 8q 
                 11h 
                 10c 
                 5v 
               
               
                   
                 III-42 
                 9a, 8h 
                 8q 
                 11i 
                 10c 
                 5v 
               
               
                   
                 III-43 
                 9a, 8h 
                 8q 
                 11j 
                 10c 
                 5v 
               
               
                   
                 III-44 
                 9a, 8h 
                 8q 
                 11k 
                 10c 
                 5v 
               
               
                   
                 III-45 
                 9a, 8h 
                 8q 
                 11l 
                 10c 
                 5v 
               
               
                   
                 III-46 
                 9a, 8h 
                 8q 
                 11m 
                 10c 
                 5v 
               
               
                   
                 III-47 
                 9a, 8h 
                 8q 
                 11n 
                 10c 
                 5v 
               
               
                   
                 III-48 
                 9a, 8h 
                 8q 
                 11o 
                 10c 
                 5v 
               
               
                   
                 III-49 
                 9a, 8h 
                 8q 
                 11p 
                 10c 
                 5v 
               
               
                   
                 III-50 
                 9a, 8h 
                 8q 
                 11q 
                 10c 
                 5v 
               
               
                   
                 III-51 
                 9a, 8h 
                 8q 
                 11r 
                 10c 
                 5v 
               
               
                   
                 III-52 
                 9a, 8h 
                 8q 
                 11s 
                 10c 
                 5v 
               
               
                   
                 III-53 
                 9a, 8h 
                 8q 
                 11t 
                 10c 
                 5v 
               
               
                   
                 III-54 
                 9a, 8h 
                 8q 
                 11u 
                 10c 
                 5v 
               
               
                   
                 III-55 
                 9a, 8h 
                 8q 
                 11v 
                 10c 
                 5v 
               
               
                   
                 III-56 
                 9a, 8h 
                 8q 
                 11w 
                 10c 
                 5v 
               
               
                   
                 III-57 
                 9a, 8h 
                 8q 
                 11x 
                 10c 
                 5v 
               
               
                   
                 III-58 
                 9a, 8h 
                 8q 
                 11y 
                 10c 
                 5v 
               
               
                   
                 III-59 
                 9a, 8h 
                 8q 
                 11z 
                 10c 
                 5v 
               
               
                   
                 III-60 
                 9a, 8h 
                 8q 
                 11aa 
                 10c 
                 5v 
               
               
                   
                 III-61 
                 9a, 8h 
                 8q 
                 11bb 
                 10c 
                 5v 
               
               
                   
                 III-62 
                 9a, 8h 
                 8q 
                 11cc 
                 10c 
                 5v 
               
               
                   
                 III-63 
                 9a, 8h 
                 8q 
                 11dd 
                 10c 
                 5v 
               
               
                   
                 III-64 
                 9a, 8h 
                 8q 
                 11ee 
                 10c 
                 5v 
               
               
                   
                 III-65 
                 9a, 8h 
                 8q 
                 11ff 
                 10c 
                 5v 
               
               
                   
                 III-66 
                 9a, 8h 
                 8q 
                 11gg 
                 10c 
                 5v 
               
               
                   
                 III-67 
                 9d, 8k 
                 8m 
                 11a 
                 10c 
                 5v 
               
               
                   
                 III-68 
                 9d, 8k 
                 8m 
                 11b 
                 10c 
                 5v 
               
               
                   
                 III-69 
                 9d, 8k 
                 8m 
                 11c 
                 10c 
                 5v 
               
               
                   
                 III-70 
                 9d, 8k 
                 8m 
                 11d 
                 10c 
                 5v 
               
               
                   
                 III-71 
                 9d, 8k 
                 8m 
                 11e 
                 10c 
                 5v 
               
               
                   
                 III-72 
                 9d, 8k 
                 8m 
                 11f 
                 10c 
                 5v 
               
               
                   
                 III-73 
                 9d, 8k 
                 8m 
                 11g 
                 10c 
                 5v 
               
               
                   
                 III-74 
                 9d, 8k 
                 8m 
                 11h 
                 10c 
                 5v 
               
               
                   
                 III-75 
                 9d, 8k 
                 8m 
                 11i 
                 10c 
                 5v 
               
               
                   
                 III-76 
                 9d, 8k 
                 8m 
                 11j 
                 10c 
                 5v 
               
               
                   
                 III-77 
                 9d, 8k 
                 8m 
                 11k 
                 10c 
                 5v 
               
               
                   
                 III-78 
                 9d, 8k 
                 8m 
                 11l 
                 10c 
                 5v 
               
               
                   
                 III-79 
                 9d, 8k 
                 8m 
                 11m 
                 10c 
                 5v 
               
               
                   
                 III-80 
                 9d, 8k 
                 8m 
                 11n 
                 10c 
                 5v 
               
               
                   
                 III-81 
                 9d, 8k 
                 8m 
                 11o 
                 10c 
                 5v 
               
               
                   
                 III-82 
                 9d, 8k 
                 8m 
                 11p 
                 10c 
                 5v 
               
               
                   
                 III-83 
                 9d, 8k 
                 8m 
                 11q 
                 10c 
                 5v 
               
               
                   
                 III-84 
                 9d, 8k 
                 8m 
                 11r 
                 10c 
                 5v 
               
               
                   
                 III-85 
                 9d, 8k 
                 8m 
                 11s 
                 10c 
                 5v 
               
               
                   
                 III-86 
                 9d, 8k 
                 8m 
                 11t 
                 10c 
                 5v 
               
               
                   
                 III-87 
                 9d, 8k 
                 8m 
                 11u 
                 10c 
                 5v 
               
               
                   
                 III-88 
                 9d, 8k 
                 8m 
                 11v 
                 10c 
                 5v 
               
               
                   
                 III-89 
                 9d, 8k 
                 8m 
                 11w 
                 10c 
                 5v 
               
               
                   
                 III-90 
                 9d, 8k 
                 8m 
                 11x 
                 10c 
                 5v 
               
               
                   
                 III-91 
                 9d, 8k 
                 8m 
                 11y 
                 10c 
                 5v 
               
               
                   
                 III-92 
                 9d, 8k 
                 8m 
                 11z 
                 10c 
                 5v 
               
               
                   
                 III-93 
                 9d, 8k 
                 8m 
                 11aa 
                 10c 
                 5v 
               
               
                   
                 III-94 
                 9d, 8k 
                 8m 
                 11bb 
                 10c 
                 5v 
               
               
                   
                 III-95 
                 9d, 8k 
                 8m 
                 11cc 
                 10c 
                 5v 
               
               
                   
                 III-96 
                 9d, 8k 
                 8m 
                 11dd 
                 10c 
                 5v 
               
               
                   
                 III-97 
                 9d, 8k 
                 8m 
                 11ee 
                 10c 
                 5v 
               
               
                   
                 III-98 
                 9d, 8k 
                 8m 
                 11ff 
                 10c 
                 5v 
               
               
                   
                 III-99 
                 9d, 8k 
                 8m 
                 11gg 
                 10c 
                 5v 
               
               
                   
                 III-100 
                 9d, 8k 
                 8q 
                 11a 
                 10c 
                 5v 
               
               
                   
                 III-101 
                 9d, 8k 
                 8q 
                 11b 
                 10c 
                 5v 
               
               
                   
                 III-102 
                 9d, 8k 
                 8q 
                 11c 
                 10c 
                 5v 
               
               
                   
                 III-103 
                 9d, 8k 
                 8q 
                 11d 
                 10c 
                 5v 
               
               
                   
                 III-104 
                 9d, 8k 
                 8q 
                 11e 
                 10c 
                 5v 
               
               
                   
                 III-105 
                 9d, 8k 
                 8q 
                 11f 
                 10c 
                 5v 
               
               
                   
                 III-106 
                 9d, 8k 
                 8q 
                 11g 
                 10c 
                 5v 
               
               
                   
                 III-107 
                 9d, 8k 
                 8q 
                 11h 
                 10c 
                 5v 
               
               
                   
                 III-108 
                 9d, 8k 
                 8q 
                 11i 
                 10c 
                 5v 
               
               
                   
                 III-109 
                 9d, 8k 
                 8q 
                 11j 
                 10c 
                 5v 
               
               
                   
                 III-110 
                 9d, 8k 
                 8q 
                 11k 
                 10c 
                 5v 
               
               
                   
                 III-111 
                 9d, 8k 
                 8q 
                 11l 
                 10c 
                 5v 
               
               
                   
                 III-112 
                 9d, 8k 
                 8q 
                 11m 
                 10c 
                 5v 
               
               
                   
                 III-113 
                 9d, 8k 
                 8q 
                 11n 
                 10c 
                 5v 
               
               
                   
                 III-114 
                 9d, 8k 
                 8q 
                 11o 
                 10c 
                 5v 
               
               
                   
                 III-115 
                 9d, 8k 
                 8q 
                 11p 
                 10c 
                 5v 
               
               
                   
                 III-116 
                 9d, 8k 
                 8q 
                 11q 
                 10c 
                 5v 
               
               
                   
                 III-117 
                 9d, 8k 
                 8q 
                 11r 
                 10c 
                 5v 
               
               
                   
                 III-118 
                 9d, 8k 
                 8q 
                 11s 
                 10c 
                 5v 
               
               
                   
                 III-119 
                 9d, 8k 
                 8q 
                 11t 
                 10c 
                 5v 
               
               
                   
                 III-120 
                 9d, 8k 
                 8q 
                 11u 
                 10c 
                 5v 
               
               
                   
                 III-121 
                 9d, 8k 
                 8q 
                 11v 
                 10c 
                 5v 
               
               
                   
                 III-122 
                 9d, 8k 
                 8q 
                 11w 
                 10c 
                 5v 
               
               
                   
                 III-123 
                 9d, 8k 
                 8q 
                 11x 
                 10c 
                 5v 
               
               
                   
                 III-124 
                 9d, 8k 
                 8q 
                 11y 
                 10c 
                 5v 
               
               
                   
                 III-125 
                 9d, 8k 
                 8q 
                 11z 
                 10c 
                 5v 
               
               
                   
                 III-126 
                 9d, 8k 
                 8q 
                 11aa 
                 10c 
                 5v 
               
               
                   
                 III-127 
                 9d, 8k 
                 8q 
                 11bb 
                 10c 
                 5v 
               
               
                   
                 III-128 
                 9d, 8k 
                 8q 
                 11cc 
                 10c 
                 5v 
               
               
                   
                 III-129 
                 9d, 8k 
                 8q 
                 11dd 
                 10c 
                 5v 
               
               
                   
                 III-130 
                 9d, 8k 
                 8q 
                 11ee 
                 10c 
                 5v 
               
               
                   
                 III-131 
                 9d, 8k 
                 8q 
                 11ff 
                 10c 
                 5v 
               
               
                   
                 III-132 
                 9d, 8k 
                 8q 
                 11gg 
                 10c 
                 5v 
               
               
                   
                 III-133 
                 9a, 8h 
                 8m 
                 11a 
                 10c 
                 5y 
               
               
                   
                 III-134 
                 9a, 8h 
                 8m 
                 11b 
                 10c 
                 5y 
               
               
                   
                 III-135 
                 9a, 8h 
                 8m 
                 11c 
                 10c 
                 5y 
               
               
                   
                 III-136 
                 9a, 8h 
                 8m 
                 11d 
                 10c 
                 5y 
               
               
                   
                 III-137 
                 9a, 8h 
                 8m 
                 11e 
                 10c 
                 5y 
               
               
                   
                 III-138 
                 9a, 8h 
                 8m 
                 11f 
                 10c 
                 5y 
               
               
                   
                 III-139 
                 9a, 8h 
                 8m 
                 11g 
                 10c 
                 5y 
               
               
                   
                 III-140 
                 9a, 8h 
                 8m 
                 11h 
                 10c 
                 5y 
               
               
                   
                 III-141 
                 9a, 8h 
                 8m 
                 11i 
                 10c 
                 5y 
               
               
                   
                 III-142 
                 9a, 8h 
                 8m 
                 11j 
                 10c 
                 5y 
               
               
                   
                 III-143 
                 9a, 8h 
                 8m 
                 11k 
                 10c 
                 5y 
               
               
                   
                 III-144 
                 9a, 8h 
                 8m 
                 11l 
                 10c 
                 5y 
               
               
                   
                 III-145 
                 9a, 8h 
                 8m 
                 11m 
                 10c 
                 5y 
               
               
                   
                 III-146 
                 9a, 8h 
                 8m 
                 11n 
                 10c 
                 5y 
               
               
                   
                 III-147 
                 9a, 8h 
                 8m 
                 11o 
                 10c 
                 5y 
               
               
                   
                 III-148 
                 9a, 8h 
                 8m 
                 11p 
                 10c 
                 5y 
               
               
                   
                 III-149 
                 9a, 8h 
                 8m 
                 11q 
                 10c 
                 5y 
               
               
                   
                 III-150 
                 9a, 8h 
                 8m 
                 11r 
                 10c 
                 5y 
               
               
                   
                 III-151 
                 9a, 8h 
                 8m 
                 11s 
                 10c 
                 5y 
               
               
                   
                 III-152 
                 9a, 8h 
                 8m 
                 11t 
                 10c 
                 5y 
               
               
                   
                 III-153 
                 9a, 8h 
                 8m 
                 11u 
                 10c 
                 5y 
               
               
                   
                 III-154 
                 9a, 8h 
                 8m 
                 11v 
                 10c 
                 5y 
               
               
                   
                 III-155 
                 9a, 8h 
                 8m 
                 11w 
                 10c 
                 5y 
               
               
                   
                 III-156 
                 9a, 8h 
                 8m 
                 11x 
                 10c 
                 5y 
               
               
                   
                 III-157 
                 9a, 8h 
                 8m 
                 11y 
                 10c 
                 5y 
               
               
                   
                 III-158 
                 9a, 8h 
                 8m 
                 11z 
                 10c 
                 5y 
               
               
                   
                 III-159 
                 9a, 8h 
                 8m 
                 11aa 
                 10c 
                 5y 
               
               
                   
                 III-160 
                 9a, 8h 
                 8m 
                 11bb 
                 10c 
                 5y 
               
               
                   
                 III-161 
                 9a, 8h 
                 8m 
                 11cc 
                 10c 
                 5y 
               
               
                   
                 III-162 
                 9a, 8h 
                 8m 
                 1dd 
                 10c 
                 5y 
               
               
                   
                 III-163 
                 9a, 8h 
                 8m 
                 11ee 
                 10c 
                 5y 
               
               
                   
                 III-164 
                 9a, 8h 
                 8m 
                 11ff 
                 10c 
                 5y 
               
               
                   
                 III-165 
                 9a, 8h 
                 8m 
                 11gg 
                 10c 
                 5y 
               
               
                   
                 III-166 
                 9a, 8h 
                 8q 
                 11a 
                 10c 
                 5y 
               
               
                   
                 III-167 
                 9a, 8h 
                 8q 
                 11b 
                 10c 
                 5y 
               
               
                   
                 III-168 
                 9a, 8h 
                 8q 
                 11c 
                 10c 
                 5y 
               
               
                   
                 III-169 
                 9a, 8h 
                 8q 
                 11d 
                 10c 
                 5y 
               
               
                   
                 III-170 
                 9a, 8h 
                 8q 
                 11e 
                 10c 
                 5y 
               
               
                   
                 III-171 
                 9a, 8h 
                 8q 
                 11f 
                 10c 
                 5y 
               
               
                   
                 III-172 
                 9a, 8h 
                 8q 
                 11g 
                 10c 
                 5y 
               
               
                   
                 III-173 
                 9a, 8h 
                 8q 
                 11h 
                 10c 
                 5y 
               
               
                   
                 III-174 
                 9a, 8h 
                 8q 
                 11i 
                 10c 
                 5y 
               
               
                   
                 III-175 
                 9a, 8h 
                 8q 
                 11j 
                 10c 
                 5y 
               
               
                   
                 III-176 
                 9a, 8h 
                 8q 
                 11k 
                 10c 
                 5y 
               
               
                   
                 III-177 
                 9a, 8h 
                 8q 
                 11l 
                 10c 
                 5y 
               
               
                   
                 III-178 
                 9a, 8h 
                 8q 
                 11m 
                 10c 
                 5y 
               
               
                   
                 III-179 
                 9a, 8h 
                 8q 
                 11n 
                 10c 
                 5y 
               
               
                   
                 III-180 
                 9a, 8h 
                 8q 
                 11o 
                 10c 
                 5y 
               
               
                   
                 III-181 
                 9a, 8h 
                 8q 
                 11p 
                 10c 
                 5y 
               
               
                   
                 III-182 
                 9a, 8h 
                 8q 
                 11q 
                 10c 
                 5y 
               
               
                   
                 III-183 
                 9a, 8h 
                 8q 
                 11r 
                 10c 
                 5y 
               
               
                   
                 III-184 
                 9a, 8h 
                 8q 
                 11s 
                 10c 
                 5y 
               
               
                   
                 III-185 
                 9a, 8h 
                 8q 
                 11t 
                 10c 
                 5y 
               
               
                   
                 III-186 
                 9a, 8h 
                 8q 
                 11u 
                 10c 
                 5y 
               
               
                   
                 III-187 
                 9a, 8h 
                 8q 
                 11v 
                 10c 
                 5y 
               
               
                   
                 III-188 
                 9a, 8h 
                 8q 
                 11w 
                 10c 
                 5y 
               
               
                   
                 III-189 
                 9a, 8h 
                 8q 
                 11x 
                 10c 
                 5y 
               
               
                   
                 III-190 
                 9a, 8h 
                 8q 
                 11y 
                 10c 
                 5y 
               
               
                   
                 III-191 
                 9a, 8h 
                 8q 
                 11z 
                 10c 
                 5y 
               
               
                   
                 III-192 
                 9a, 8h 
                 8q 
                 11aa 
                 10c 
                 5y 
               
               
                   
                 III-193 
                 9a, 8h 
                 8q 
                 11bb 
                 10c 
                 5y 
               
               
                   
                 III-194 
                 9a, 8h 
                 8q 
                 11cc 
                 10c 
                 5y 
               
               
                   
                 III-195 
                 9a, 8h 
                 8q 
                 11dd 
                 10c 
                 5y 
               
               
                   
                 III-196 
                 9a, 8h 
                 8q 
                 11ee 
                 10c 
                 5y 
               
               
                   
                 III-197 
                 9a, 8h 
                 8q 
                 11ff 
                 10c 
                 5y 
               
               
                   
                 III-198 
                 9a, 8h 
                 8q 
                 11gg 
                 10c 
                 5y 
               
               
                   
                 III-199 
                 9d, 8k 
                 8m 
                 11a 
                 10c 
                 5y 
               
               
                   
                 III-200 
                 9d, 8k 
                 8m 
                 11b 
                 10c 
                 5y 
               
               
                   
                 III-201 
                 9d, 8k 
                 8m 
                 11c 
                 10c 
                 5y 
               
               
                   
                 III-202 
                 9d, 8k 
                 8m 
                 11d 
                 10c 
                 5y 
               
               
                   
                 III-203 
                 9d, 8k 
                 8m 
                 11e 
                 10c 
                 5y 
               
               
                   
                 III-204 
                 9d, 8k 
                 8m 
                 11f 
                 10c 
                 5y 
               
               
                   
                 III-205 
                 9d, 8k 
                 8m 
                 11g 
                 10c 
                 5y 
               
               
                   
                 III-206 
                 9d, 8k 
                 8m 
                 11h 
                 10c 
                 5y 
               
               
                   
                 III-207 
                 9d, 8k 
                 8m 
                 11i 
                 10c 
                 5y 
               
               
                   
                 III-208 
                 9d, 8k 
                 8m 
                 11j 
                 10c 
                 5y 
               
               
                   
                 III-209 
                 9d, 8k 
                 8m 
                 11k 
                 10c 
                 5y 
               
               
                   
                 III-210 
                 9d, 8k 
                 8m 
                 11l 
                 10c 
                 5y 
               
               
                   
                 III-211 
                 9d, 8k 
                 8m 
                 11m 
                 10c 
                 5y 
               
               
                   
                 III-212 
                 9d, 8k 
                 8m 
                 11n 
                 10c 
                 5y 
               
               
                   
                 III-213 
                 9d, 8k 
                 8m 
                 11o 
                 10c 
                 5y 
               
               
                   
                 III-214 
                 9d, 8k 
                 8m 
                 11p 
                 10c 
                 5y 
               
               
                   
                 III-215 
                 9d, 8k 
                 8m 
                 11q 
                 10c 
                 5y 
               
               
                   
                 III-216 
                 9d, 8k 
                 8m 
                 11r 
                 10c 
                 5y 
               
               
                   
                 III-217 
                 9d, 8k 
                 8m 
                 11s 
                 10c 
                 5y 
               
               
                   
                 III-218 
                 9d, 8k 
                 8m 
                 11t 
                 10c 
                 5y 
               
               
                   
                 III-219 
                 9d, 8k 
                 8m 
                 11u 
                 10c 
                 5y 
               
               
                   
                 III-220 
                 9d, 8k 
                 8m 
                 11v 
                 10c 
                 5y 
               
               
                   
                 III-221 
                 9d, 8k 
                 8m 
                 11w 
                 10c 
                 5y 
               
               
                   
                 III-222 
                 9d, 8k 
                 8m 
                 11x 
                 10c 
                 5y 
               
               
                   
                 III-223 
                 9d, 8k 
                 8m 
                 11y 
                 10c 
                 5y 
               
               
                   
                 III-224 
                 9d, 8k 
                 8m 
                 11z 
                 10c 
                 5y 
               
               
                   
                 III-225 
                 9d, 8k 
                 8m 
                 11aa 
                 10c 
                 5y 
               
               
                   
                 III-226 
                 9d, 8k 
                 8m 
                 11bb 
                 10c 
                 5y 
               
               
                   
                 III-227 
                 9d, 8k 
                 8m 
                 11cc 
                 10c 
                 5y 
               
               
                   
                 III-228 
                 9d, 8k 
                 8m 
                 11dd 
                 10c 
                 5y 
               
               
                   
                 III-229 
                 9d, 8k 
                 8m 
                 11ee 
                 10c 
                 5y 
               
               
                   
                 III-230 
                 9d, 8k 
                 8m 
                 11ff 
                 10c 
                 5y 
               
               
                   
                 III-231 
                 9d, 8k 
                 8m 
                 11gg 
                 10c 
                 5y 
               
               
                   
                 III-232 
                 9d, 8k 
                 8q 
                 11a 
                 10c 
                 5y 
               
               
                   
                 III-233 
                 9d, 8k 
                 8q 
                 11b 
                 10c 
                 5y 
               
               
                   
                 III-234 
                 9d, 8k 
                 8q 
                 11c 
                 10c 
                 5y 
               
               
                   
                 III-235 
                 9d, 8k 
                 8q 
                 11d 
                 10c 
                 5y 
               
               
                   
                 III-236 
                 9d, 8k 
                 8q 
                 11e 
                 10c 
                 5y 
               
               
                   
                 III-237 
                 9d, 8k 
                 8q 
                 11f 
                 10c 
                 5y 
               
               
                   
                 III-238 
                 9d, 8k 
                 8q 
                 11g 
                 10c 
                 5y 
               
               
                   
                 III-239 
                 9d, 8k 
                 8q 
                 11h 
                 10c 
                 5y 
               
               
                   
                 III-240 
                 9d, 8k 
                 8q 
                 11i 
                 10c 
                 5y 
               
               
                   
                 III-241 
                 9d, 8k 
                 8q 
                 11j 
                 10c 
                 5y 
               
               
                   
                 III-242 
                 9d, 8k 
                 8q 
                 11k 
                 10c 
                 5y 
               
               
                   
                 III-243 
                 9d, 8k 
                 8q 
                 11l 
                 10c 
                 5y 
               
               
                   
                 III-244 
                 9d, 8k 
                 8q 
                 11m 
                 10c 
                 5y 
               
               
                   
                 III-245 
                 9d, 8k 
                 8q 
                 11n 
                 10c 
                 5y 
               
               
                   
                 III-246 
                 9d, 8k 
                 8q 
                 11o 
                 10c 
                 5y 
               
               
                   
                 III-247 
                 9d, 8k 
                 8q 
                 11p 
                 10c 
                 5y 
               
               
                   
                 III-248 
                 9d, 8k 
                 8q 
                 11q 
                 10c 
                 5y 
               
               
                   
                 III-249 
                 9d, 8k 
                 8q 
                 11r 
                 10c 
                 5y 
               
               
                   
                 III-250 
                 9d, 8k 
                 8q 
                 11s 
                 10c 
                 5y 
               
               
                   
                 III-251 
                 9d, 8k 
                 8q 
                 11t 
                 10c 
                 5y 
               
               
                   
                 III-252 
                 9d, 8k 
                 8q 
                 11u 
                 10c 
                 5y 
               
               
                   
                 III-253 
                 9d, 8k 
                 8q 
                 11v 
                 10c 
                 5y 
               
               
                   
                 III-254 
                 9d, 8k 
                 8q 
                 11w 
                 10c 
                 5y 
               
               
                   
                 III-255 
                 9d, 8k 
                 8q 
                 11x 
                 10c 
                 5y 
               
               
                   
                 III-256 
                 9d, 8k 
                 8q 
                 11y 
                 10c 
                 5y 
               
               
                   
                 III-257 
                 9d, 8k 
                 8q 
                 11z 
                 10c 
                 5y 
               
               
                   
                 III-258 
                 9d, 8k 
                 8q 
                 11aa 
                 10c 
                 5y 
               
               
                   
                 III-259 
                 9d, 8k 
                 8q 
                 11bb 
                 10c 
                 5y 
               
               
                   
                 III-260 
                 9d, 8k 
                 8q 
                 11cc 
                 10c 
                 5y 
               
               
                   
                 III-261 
                 9d, 8k 
                 8q 
                 11dd 
                 10c 
                 5y 
               
               
                   
                 III-262 
                 9d, 8k 
                 8q 
                 11ee 
                 10c 
                 5y 
               
               
                   
                 III-263 
                 9d, 8k 
                 8q 
                 11ff 
                 10c 
                 5y 
               
               
                   
                 III-264 
                 9d, 8k 
                 8q 
                 11gg 
                 10c 
                 5y 
               
               
                   
                   
               
             
          
         
       
     
         [0244]    In embodiment (4) of the first aspect, the invention comprises the compound of formula (IV), or any one of (IVa)-(IVe), 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    and pharmaceutically acceptable salts thereof, wherein R 20  is —C 1 -C 7 alkyl-R 9 , -aryl-R 9 , -aryl(C 1 -C 7 )alkyl-R 9 , or -heteroaryl-R 9 , and R 3 , R 5 , R 6 , L I , and R 9  are as defined for formula (I). 
         [0245]    The invention further comprises subgenera of embodiment (4) of the first aspect in which the substituents are selected as anvand all combinations of R 3 , R 5 , R 6 , R 20 , L 1 , X, and Y as defined herein, including without limitation, 
         [0246]    each R 3  is independently one of groups (9a)-(9e) as defined above for formula (II). 
         [0247]    R 5  is one of groups (8h)-(8l) as defined above for formula (I). 
         [0248]    each R 6  is independently one of groups (8m)-(8q) as defined above for formula (I). 
         [0249]    L 1  is one of groups (5v)-(5z) as defined above for formula (I). 
         [0250]    X and Y are one of groups (7a)-(7g) as defined above for formula (I). 
         [0251]    R 20  is one of groups (11a)-(11gg) as defined above for formula (II). 
         [0252]    Particular embodiments of this embodiment of the invention include compounds of any one of formulae (IV) and (IVa)-(IVe) wherein are defined in each of the following rows, wherein each entry is a group number as defined above: 
         [0000]    
       
         
               
               
               
               
               
               
             
           
               
                   
                   
               
               
                   
                 Embodiment 
                 R 3  &amp; R 5   
                 R 6   
                 R 20   
                 L 1   
               
               
                   
                   
               
             
             
               
                   
                 IV-1 
                 9a, 8h 
                 8m 
                 11a 
                 5v 
               
               
                   
                 IV-2 
                 9a, 8h 
                 8m 
                 11b 
                 5v 
               
               
                   
                 IV-3 
                 9a, 8h 
                 8m 
                 11c 
                 5v 
               
               
                   
                 IV-4 
                 9a, 8h 
                 8m 
                 11d 
                 5v 
               
               
                   
                 IV-5 
                 9a, 8h 
                 8m 
                 11e 
                 5v 
               
               
                   
                 IV-6 
                 9a, 8h 
                 8m 
                 11f 
                 5v 
               
               
                   
                 IV-7 
                 9a, 8h 
                 8m 
                 11g 
                 5v 
               
               
                   
                 IV-8 
                 9a, 8h 
                 8m 
                 11h 
                 5v 
               
               
                   
                 IV-9 
                 9a, 8h 
                 8m 
                 11i 
                 5v 
               
               
                   
                 IV-10 
                 9a, 8h 
                 8m 
                 11j 
                 5v 
               
               
                   
                 IV-11 
                 9a, 8h 
                 8m 
                 11k 
                 5v 
               
               
                   
                 IV-12 
                 9a, 8h 
                 8m 
                 11l 
                 5v 
               
               
                   
                 IV-13 
                 9a, 8h 
                 8m 
                 11m 
                 5v 
               
               
                   
                 IV-14 
                 9a, 8h 
                 8m 
                 11n 
                 5v 
               
               
                   
                 IV-15 
                 9a, 8h 
                 8m 
                 11o 
                 5v 
               
               
                   
                 IV-16 
                 9a, 8h 
                 8m 
                 11p 
                 5v 
               
               
                   
                 IV-17 
                 9a, 8h 
                 8m 
                 11q 
                 5v 
               
               
                   
                 IV-18 
                 9a, 8h 
                 8m 
                 11r 
                 5v 
               
               
                   
                 IV-19 
                 9a, 8h 
                 8m 
                 11s 
                 5v 
               
               
                   
                 IV-20 
                 9a, 8h 
                 8m 
                 11t 
                 5v 
               
               
                   
                 IV-21 
                 9a, 8h 
                 8m 
                 11u 
                 5v 
               
               
                   
                 IV-22 
                 9a, 8h 
                 8m 
                 11v 
                 5v 
               
               
                   
                 IV-23 
                 9a, 8h 
                 8m 
                 11w 
                 5v 
               
               
                   
                 IV-24 
                 9a, 8h 
                 8m 
                 11x 
                 5v 
               
               
                   
                 IV-25 
                 9a, 8h 
                 8m 
                 11y 
                 5v 
               
               
                   
                 IV-26 
                 9a, 8h 
                 8m 
                 11z 
                 5v 
               
               
                   
                 IV-27 
                 9a, 8h 
                 8m 
                 11aa 
                 5v 
               
               
                   
                 IV-28 
                 9a, 8h 
                 8m 
                 11bb 
                 5v 
               
               
                   
                 IV-29 
                 9a, 8h 
                 8m 
                 11cc 
                 5v 
               
               
                   
                 IV-30 
                 9a, 8h 
                 8m 
                 11dd 
                 5v 
               
               
                   
                 IV-31 
                 9a, 8h 
                 8m 
                 11ee 
                 5v 
               
               
                   
                 IV-32 
                 9a, 8h 
                 8m 
                 11ff 
                 5v 
               
               
                   
                 IV-33 
                 9a, 8h 
                 8m 
                 11gg 
                 5v 
               
               
                   
                 IV-34 
                 9a, 8h 
                 8q 
                 11a 
                 5v 
               
               
                   
                 IV-35 
                 9a, 8h 
                 8q 
                 11b 
                 5v 
               
               
                   
                 IV-36 
                 9a, 8h 
                 8q 
                 11c 
                 5v 
               
               
                   
                 IV-37 
                 9a, 8h 
                 8q 
                 11d 
                 5v 
               
               
                   
                 IV-38 
                 9a, 8h 
                 8q 
                 11e 
                 5v 
               
               
                   
                 IV-39 
                 9a, 8h 
                 8q 
                 11f 
                 5v 
               
               
                   
                 IV-40 
                 9a, 8h 
                 8q 
                 11g 
                 5v 
               
               
                   
                 IV-41 
                 9a, 8h 
                 8q 
                 11h 
                 5v 
               
               
                   
                 IV-42 
                 9a, 8h 
                 8q 
                 11i 
                 5v 
               
               
                   
                 IV-43 
                 9a, 8h 
                 8q 
                 11j 
                 5v 
               
               
                   
                 IV-44 
                 9a, 8h 
                 8q 
                 11k 
                 5v 
               
               
                   
                 IV-45 
                 9a, 8h 
                 8q 
                 11l 
                 5v 
               
               
                   
                 IV-46 
                 9a, 8h 
                 8q 
                 11m 
                 5v 
               
               
                   
                 IV-47 
                 9a, 8h 
                 8q 
                 11n 
                 5v 
               
               
                   
                 IV-48 
                 9a, 8h 
                 8q 
                 11o 
                 5v 
               
               
                   
                 IV-49 
                 9a, 8h 
                 8q 
                 11p 
                 5v 
               
               
                   
                 IV-50 
                 9a, 8h 
                 8q 
                 11q 
                 5v 
               
               
                   
                 IV-51 
                 9a, 8h 
                 8q 
                 11r 
                 5v 
               
               
                   
                 IV-52 
                 9a, 8h 
                 8q 
                 11s 
                 5v 
               
               
                   
                 IV-53 
                 9a, 8h 
                 8q 
                 11t 
                 5v 
               
               
                   
                 IV-54 
                 9a, 8h 
                 8q 
                 11u 
                 5v 
               
               
                   
                 IV-55 
                 9a, 8h 
                 8q 
                 11v 
                 5v 
               
               
                   
                 IV-56 
                 9a, 8h 
                 8q 
                 11w 
                 5v 
               
               
                   
                 IV-57 
                 9a, 8h 
                 8q 
                 11x 
                 5v 
               
               
                   
                 IV-58 
                 9a, 8h 
                 8q 
                 11y 
                 5v 
               
               
                   
                 IV-59 
                 9a, 8h 
                 8q 
                 11z 
                 5v 
               
               
                   
                 IV-60 
                 9a, 8h 
                 8q 
                 11aa 
                 5v 
               
               
                   
                 IV-61 
                 9a, 8h 
                 8q 
                 11bb 
                 5v 
               
               
                   
                 IV-62 
                 9a, 8h 
                 8q 
                 11cc 
                 5v 
               
               
                   
                 IV-63 
                 9a, 8h 
                 8q 
                 11dd 
                 5v 
               
               
                   
                 IV-64 
                 9a, 8h 
                 8q 
                 11ee 
                 5v 
               
               
                   
                 IV-65 
                 9a, 8h 
                 8q 
                 11ff 
                 5v 
               
               
                   
                 IV-66 
                 9a, 8h 
                 8q 
                 11gg 
                 5v 
               
               
                   
                 IV-67 
                 9d, 8k 
                 8m 
                 11a 
                 5v 
               
               
                   
                 IV-68 
                 9d, 8k 
                 8m 
                 11b 
                 5v 
               
               
                   
                 IV-69 
                 9d, 8k 
                 8m 
                 11c 
                 5v 
               
               
                   
                 IV-70 
                 9d, 8k 
                 8m 
                 11d 
                 5v 
               
               
                   
                 IV-71 
                 9d, 8k 
                 8m 
                 11e 
                 5v 
               
               
                   
                 IV-72 
                 9d, 8k 
                 8m 
                 11f 
                 5v 
               
               
                   
                 IV-73 
                 9d, 8k 
                 8m 
                 11g 
                 5v 
               
               
                   
                 IV-74 
                 9d, 8k 
                 8m 
                 11h 
                 5v 
               
               
                   
                 IV-75 
                 9d, 8k 
                 8m 
                 11i 
                 5v 
               
               
                   
                 IV-76 
                 9d, 8k 
                 8m 
                 11j 
                 5v 
               
               
                   
                 IV-77 
                 9d, 8k 
                 8m 
                 11k 
                 5v 
               
               
                   
                 IV-78 
                 9d, 8k 
                 8m 
                 11l 
                 5v 
               
               
                   
                 IV-79 
                 9d, 8k 
                 8m 
                 11m 
                 5v 
               
               
                   
                 IV-80 
                 9d, 8k 
                 8m 
                 11n 
                 5v 
               
               
                   
                 IV-81 
                 9d, 8k 
                 8m 
                 11o 
                 5v 
               
               
                   
                 IV-82 
                 9d, 8k 
                 8m 
                 11p 
                 5v 
               
               
                   
                 IV-83 
                 9d, 8k 
                 8m 
                 11q 
                 5v 
               
               
                   
                 IV-84 
                 9d, 8k 
                 8m 
                 11r 
                 5v 
               
               
                   
                 IV-85 
                 9d, 8k 
                 8m 
                 11s 
                 5v 
               
               
                   
                 IV-86 
                 9d, 8k 
                 8m 
                 11t 
                 5v 
               
               
                   
                 IV-87 
                 9d, 8k 
                 8m 
                 11u 
                 5v 
               
               
                   
                 IV-88 
                 9d, 8k 
                 8m 
                 11v 
                 5v 
               
               
                   
                 IV-89 
                 9d, 8k 
                 8m 
                 11w 
                 5v 
               
               
                   
                 IV-90 
                 9d, 8k 
                 8m 
                 11x 
                 5v 
               
               
                   
                 IV-91 
                 9d, 8k 
                 8m 
                 11y 
                 5v 
               
               
                   
                 IV-92 
                 9d, 8k 
                 8m 
                 11z 
                 5v 
               
               
                   
                 IV-93 
                 9d, 8k 
                 8m 
                 11aa 
                 5v 
               
               
                   
                 IV-94 
                 9d, 8k 
                 8m 
                 11bb 
                 5v 
               
               
                   
                 IV-95 
                 9d, 8k 
                 8m 
                 11cc 
                 5v 
               
               
                   
                 IV-96 
                 9d, 8k 
                 8m 
                 11dd 
                 5v 
               
               
                   
                 IV-97 
                 9d, 8k 
                 8m 
                 11ee 
                 5v 
               
               
                   
                 IV-98 
                 9d, 8k 
                 8m 
                 11ff 
                 5v 
               
               
                   
                 IV-99 
                 9d, 8k 
                 8m 
                 11gg 
                 5v 
               
               
                   
                 IV-100 
                 9d, 8k 
                 8q 
                 11a 
                 5v 
               
               
                   
                 IV-101 
                 9d, 8k 
                 8q 
                 11b 
                 5v 
               
               
                   
                 IV-102 
                 9d, 8k 
                 8q 
                 11c 
                 5v 
               
               
                   
                 IV-103 
                 9d, 8k 
                 8q 
                 11d 
                 5v 
               
               
                   
                 IV-104 
                 9d, 8k 
                 8q 
                 11e 
                 5v 
               
               
                   
                 IV-105 
                 9d, 8k 
                 8q 
                 11f 
                 5v 
               
               
                   
                 IV-106 
                 9d, 8k 
                 8q 
                 11g 
                 5v 
               
               
                   
                 IV-107 
                 9d, 8k 
                 8q 
                 11h 
                 5v 
               
               
                   
                 IV-108 
                 9d, 8k 
                 8q 
                 11i 
                 5v 
               
               
                   
                 IV-109 
                 9d, 8k 
                 8q 
                 11j 
                 5v 
               
               
                   
                 IV-110 
                 9d, 8k 
                 8q 
                 11k 
                 5v 
               
               
                   
                 IV-111 
                 9d, 8k 
                 8q 
                 11l 
                 5v 
               
               
                   
                 IV-112 
                 9d, 8k 
                 8q 
                 11m 
                 5v 
               
               
                   
                 IV-113 
                 9d, 8k 
                 8q 
                 11n 
                 5v 
               
               
                   
                 IV-114 
                 9d, 8k 
                 8q 
                 11o 
                 5v 
               
               
                   
                 IV-115 
                 9d, 8k 
                 8q 
                 11p 
                 5v 
               
               
                   
                 IV-116 
                 9d, 8k 
                 8q 
                 11q 
                 5v 
               
               
                   
                 IV-117 
                 9d, 8k 
                 8q 
                 11r 
                 5v 
               
               
                   
                 IV-118 
                 9d, 8k 
                 8q 
                 11s 
                 5v 
               
               
                   
                 IV-119 
                 9d, 8k 
                 8q 
                 11t 
                 5v 
               
               
                   
                 IV-120 
                 9d, 8k 
                 8q 
                 11u 
                 5v 
               
               
                   
                 IV-121 
                 9d, 8k 
                 8q 
                 11v 
                 5v 
               
               
                   
                 IV-122 
                 9d, 8k 
                 8q 
                 11w 
                 5v 
               
               
                   
                 IV-123 
                 9d, 8k 
                 8q 
                 11x 
                 5v 
               
               
                   
                 IV-124 
                 9d, 8k 
                 8q 
                 11y 
                 5v 
               
               
                   
                 IV-125 
                 9d, 8k 
                 8q 
                 11z 
                 5v 
               
               
                   
                 IV-126 
                 9d, 8k 
                 8q 
                 11aa 
                 5v 
               
               
                   
                 IV-127 
                 9d, 8k 
                 8q 
                 11bb 
                 5v 
               
               
                   
                 IV-128 
                 9d, 8k 
                 8q 
                 11cc 
                 5v 
               
               
                   
                 IV-129 
                 9d, 8k 
                 8q 
                 11dd 
                 5v 
               
               
                   
                 IV-130 
                 9d, 8k 
                 8q 
                 11ee 
                 5v 
               
               
                   
                 IV-131 
                 9d, 8k 
                 8q 
                 11ff 
                 5v 
               
               
                   
                 IV-132 
                 9d, 8k 
                 8q 
                 11gg 
                 5v 
               
               
                   
                 IV-133 
                 9a, 8h 
                 8m 
                 11a 
                 5y 
               
               
                   
                 IV-134 
                 9a, 8h 
                 8m 
                 11b 
                 5y 
               
               
                   
                 IV-135 
                 9a, 8h 
                 8m 
                 11c 
                 5y 
               
               
                   
                 IV-136 
                 9a, 8h 
                 8m 
                 11d 
                 5y 
               
               
                   
                 IV-137 
                 9a, 8h 
                 8m 
                 11e 
                 5y 
               
               
                   
                 IV-138 
                 9a, 8h 
                 8m 
                 11f 
                 5y 
               
               
                   
                 IV-139 
                 9a, 8h 
                 8m 
                 11g 
                 5y 
               
               
                   
                 IV-140 
                 9a, 8h 
                 8m 
                 11h 
                 5y 
               
               
                   
                 IV-141 
                 9a, 8h 
                 8m 
                 11i 
                 5y 
               
               
                   
                 IV-142 
                 9a, 8h 
                 8m 
                 11j 
                 5y 
               
               
                   
                 IV-143 
                 9a, 8h 
                 8m 
                 11k 
                 5y 
               
               
                   
                 IV-144 
                 9a, 8h 
                 8m 
                 11l 
                 5y 
               
               
                   
                 IV-145 
                 9a, 8h 
                 8m 
                 11m 
                 5y 
               
               
                   
                 IV-146 
                 9a, 8h 
                 8m 
                 11n 
                 5y 
               
               
                   
                 IV-147 
                 9a, 8h 
                 8m 
                 11o 
                 5y 
               
               
                   
                 IV-148 
                 9a, 8h 
                 8m 
                 11p 
                 5y 
               
               
                   
                 IV-149 
                 9a, 8h 
                 8m 
                 11q 
                 5y 
               
               
                   
                 IV-150 
                 9a, 8h 
                 8m 
                 11r 
                 5y 
               
               
                   
                 IV-151 
                 9a, 8h 
                 8m 
                 11s 
                 5y 
               
               
                   
                 IV-152 
                 9a, 8h 
                 8m 
                 11t 
                 5y 
               
               
                   
                 IV-153 
                 9a, 8h 
                 8m 
                 11u 
                 5y 
               
               
                   
                 IV-154 
                 9a, 8h 
                 8m 
                 11v 
                 5y 
               
               
                   
                 IV-155 
                 9a, 8h 
                 8m 
                 11w 
                 5y 
               
               
                   
                 IV-156 
                 9a, 8h 
                 8m 
                 11x 
                 5y 
               
               
                   
                 IV-157 
                 9a, 8h 
                 8m 
                 11y 
                 5y 
               
               
                   
                 IV-158 
                 9a, 8h 
                 8m 
                 11z 
                 5y 
               
               
                   
                 IV-159 
                 9a, 8h 
                 8m 
                 11aa 
                 5y 
               
               
                   
                 IV-160 
                 9a, 8h 
                 8m 
                 11bb 
                 5y 
               
               
                   
                 IV-161 
                 9a, 8h 
                 8m 
                 11cc 
                 5y 
               
               
                   
                 IV-162 
                 9a, 8h 
                 8m 
                 11dd 
                 5y 
               
               
                   
                 IV-163 
                 9a, 8h 
                 8m 
                 11ee 
                 5y 
               
               
                   
                 IV-164 
                 9a, 8h 
                 8m 
                 11ff 
                 5y 
               
               
                   
                 IV-165 
                 9a, 8h 
                 8m 
                 11gg 
                 5y 
               
               
                   
                 IV-166 
                 9a, 8h 
                 8q 
                 11a 
                 5y 
               
               
                   
                 IV-167 
                 9a, 8h 
                 8q 
                 11b 
                 5y 
               
               
                   
                 IV-168 
                 9a, 8h 
                 8q 
                 11c 
                 5y 
               
               
                   
                 IV-169 
                 9a, 8h 
                 8q 
                 11d 
                 5y 
               
               
                   
                 IV-170 
                 9a, 8h 
                 8q 
                 11e 
                 5y 
               
               
                   
                 IV-171 
                 9a, 8h 
                 8q 
                 11f 
                 5y 
               
               
                   
                 IV-172 
                 9a, 8h 
                 8q 
                 11g 
                 5y 
               
               
                   
                 IV-173 
                 9a, 8h 
                 8q 
                 11h 
                 5y 
               
               
                   
                 IV-174 
                 9a, 8h 
                 8q 
                 11i 
                 5y 
               
               
                   
                 IV-175 
                 9a, 8h 
                 8q 
                 11j 
                 5y 
               
               
                   
                 IV-176 
                 9a, 8h 
                 8q 
                 11k 
                 5y 
               
               
                   
                 IV-177 
                 9a, 8h 
                 8q 
                 11l 
                 5y 
               
               
                   
                 IV-178 
                 9a, 8h 
                 8q 
                 11m 
                 5y 
               
               
                   
                 IV-179 
                 9a, 8h 
                 8q 
                 11n 
                 5y 
               
               
                   
                 IV-180 
                 9a, 8h 
                 8q 
                 11o 
                 5y 
               
               
                   
                 IV-181 
                 9a, 8h 
                 8q 
                 11p 
                 5y 
               
               
                   
                 IV-182 
                 9a, 8h 
                 8q 
                 11q 
                 5y 
               
               
                   
                 IV-183 
                 9a, 8h 
                 8q 
                 11r 
                 5y 
               
               
                   
                 IV-184 
                 9a, 8h 
                 8q 
                 11s 
                 5y 
               
               
                   
                 IV-185 
                 9a, 8h 
                 8q 
                 11t 
                 5y 
               
               
                   
                 IV-186 
                 9a, 8h 
                 8q 
                 11u 
                 5y 
               
               
                   
                 IV-187 
                 9a, 8h 
                 8q 
                 11v 
                 5y 
               
               
                   
                 IV-188 
                 9a, 8h 
                 8q 
                 11w 
                 5y 
               
               
                   
                 IV-189 
                 9a, 8h 
                 8q 
                 11x 
                 5y 
               
               
                   
                 IV-190 
                 9a, 8h 
                 8q 
                 11y 
                 5y 
               
               
                   
                 IV-191 
                 9a, 8h 
                 8q 
                 11z 
                 5y 
               
               
                   
                 IV-192 
                 9a, 8h 
                 8q 
                 11aa 
                 5y 
               
               
                   
                 IV-193 
                 9a, 8h 
                 8q 
                 11bb 
                 5y 
               
               
                   
                 IV-194 
                 9a, 8h 
                 8q 
                 11cc 
                 5y 
               
               
                   
                 IV-195 
                 9a, 8h 
                 8q 
                 11dd 
                 5y 
               
               
                   
                 IV-196 
                 9a, 8h 
                 8q 
                 11ee 
                 5y 
               
               
                   
                 IV-197 
                 9a, 8h 
                 8q 
                 11ff 
                 5y 
               
               
                   
                 IV-198 
                 9a, 8h 
                 8q 
                 11gg 
                 5y 
               
               
                   
                 IV-199 
                 9d, 8k 
                 8m 
                 11a 
                 5y 
               
               
                   
                 IV-200 
                 9d, 8k 
                 8m 
                 11b 
                 5y 
               
               
                   
                 IV-201 
                 9d, 8k 
                 8m 
                 11e 
                 5y 
               
               
                   
                 IV-202 
                 9d, 8k 
                 8m 
                 11d 
                 5y 
               
               
                   
                 IV-203 
                 9d, 8k 
                 8m 
                 11e 
                 5y 
               
               
                   
                 IV-204 
                 9d, 8k 
                 8m 
                 11f 
                 5y 
               
               
                   
                 IV-205 
                 9d, 8k 
                 8m 
                 11g 
                 5y 
               
               
                   
                 IV-206 
                 9d, 8k 
                 8m 
                 11h 
                 5y 
               
               
                   
                 IV-207 
                 9d, 8k 
                 8m 
                 11i 
                 5y 
               
               
                   
                 IV-208 
                 9d, 8k 
                 8m 
                 11j 
                 5y 
               
               
                   
                 IV-209 
                 9d, 8k 
                 8m 
                 11k 
                 5y 
               
               
                   
                 IV-210 
                 9d, 8k 
                 8m 
                 11l 
                 5y 
               
               
                   
                 IV-211 
                 9d, 8k 
                 8m 
                 11m 
                 5y 
               
               
                   
                 IV-212 
                 9d, 8k 
                 8m 
                 11n 
                 5y 
               
               
                   
                 IV-213 
                 9d, 8k 
                 8m 
                 11o 
                 5y 
               
               
                   
                 IV-214 
                 9d, 8k 
                 8m 
                 11p 
                 5y 
               
               
                   
                 IV-215 
                 9d, 8k 
                 8m 
                 11q 
                 5y 
               
               
                   
                 IV-216 
                 9d, 8k 
                 8m 
                 11r 
                 5y 
               
               
                   
                 IV-217 
                 9d, 8k 
                 8m 
                 11s 
                 5y 
               
               
                   
                 IV-218 
                 9d, 8k 
                 8m 
                 11t 
                 5y 
               
               
                   
                 IV-219 
                 9d, 8k 
                 8m 
                 11u 
                 5y 
               
               
                   
                 IV-220 
                 9d, 8k 
                 8m 
                 11v 
                 5y 
               
               
                   
                 IV-221 
                 9d, 8k 
                 8m 
                 11w 
                 5y 
               
               
                   
                 IV-222 
                 9d, 8k 
                 8m 
                 11x 
                 5y 
               
               
                   
                 IV-223 
                 9d, 8k 
                 8m 
                 11y 
                 5y 
               
               
                   
                 IV-224 
                 9d, 8k 
                 8m 
                 11z 
                 5y 
               
               
                   
                 IV-225 
                 9d, 8k 
                 8m 
                 11aa 
                 5y 
               
               
                   
                 IV-226 
                 9d, 8k 
                 8m 
                 11bb 
                 5y 
               
               
                   
                 IV-227 
                 9d, 8k 
                 8m 
                 11cc 
                 5y 
               
               
                   
                 IV-228 
                 9d, 8k 
                 8m 
                 11dd 
                 5y 
               
               
                   
                 IV-229 
                 9d, 8k 
                 8m 
                 11ee 
                 5y 
               
               
                   
                 IV-230 
                 9d, 8k 
                 8m 
                 11ff 
                 5y 
               
               
                   
                 IV-231 
                 9d, 8k 
                 8m 
                 11gg 
                 5y 
               
               
                   
                 IV-232 
                 9d, 8k 
                 8q 
                 11a 
                 5y 
               
               
                   
                 IV-233 
                 9d, 8k 
                 8q 
                 11b 
                 5y 
               
               
                   
                 IV-234 
                 9d, 8k 
                 8q 
                 11c 
                 5y 
               
               
                   
                 IV-235 
                 9d, 8k 
                 8q 
                 11d 
                 5y 
               
               
                   
                 IV-236 
                 9d, 8k 
                 8q 
                 11e 
                 5y 
               
               
                   
                 IV-237 
                 9d, 8k 
                 8q 
                 11f 
                 5y 
               
               
                   
                 IV-238 
                 9d, 8k 
                 8q 
                 11g 
                 5y 
               
               
                   
                 IV-239 
                 9d, 8k 
                 8q 
                 11h 
                 5y 
               
               
                   
                 IV-240 
                 9d, 8k 
                 8q 
                 11i 
                 5y 
               
               
                   
                 IV-241 
                 9d, 8k 
                 8q 
                 11j 
                 5y 
               
               
                   
                 IV-242 
                 9d, 8k 
                 8q 
                 11k 
                 5y 
               
               
                   
                 IV-243 
                 9d, 8k 
                 8q 
                 11l 
                 5y 
               
               
                   
                 IV-244 
                 9d, 8k 
                 8q 
                 11m 
                 5y 
               
               
                   
                 IV-245 
                 9d, 8k 
                 8q 
                 11n 
                 5y 
               
               
                   
                 IV-246 
                 9d, 8k 
                 8q 
                 11o 
                 5y 
               
               
                   
                 IV-247 
                 9d, 8k 
                 8q 
                 11p 
                 5y 
               
               
                   
                 IV-248 
                 9d, 8k 
                 8q 
                 11q 
                 5y 
               
               
                   
                 IV-249 
                 9d, 8k 
                 8q 
                 11r 
                 5y 
               
               
                   
                 IV-250 
                 9d, 8k 
                 8q 
                 11s 
                 5y 
               
               
                   
                 IV-251 
                 9d, 8k 
                 8q 
                 11t 
                 5y 
               
               
                   
                 IV-252 
                 9d, 8k 
                 8q 
                 11u 
                 5y 
               
               
                   
                 IV-253 
                 9d, 8k 
                 8q 
                 11v 
                 5y 
               
               
                   
                 IV-254 
                 9d, 8k 
                 8q 
                 11w 
                 5y 
               
               
                   
                 IV-255 
                 9d, 8k 
                 8q 
                 11x 
                 5y 
               
               
                   
                 IV-256 
                 9d, 8k 
                 8q 
                 11y 
                 5y 
               
               
                   
                 IV-257 
                 9d, 8k 
                 8q 
                 11z 
                 5y 
               
               
                   
                 IV-258 
                 9d, 8k 
                 8q 
                 11aa 
                 5y 
               
               
                   
                 IV-259 
                 9d, 8k 
                 8q 
                 11bb 
                 5y 
               
               
                   
                 IV-260 
                 9d, 8k 
                 8q 
                 11cc 
                 5y 
               
               
                   
                 IV-261 
                 9d, 8k 
                 8q 
                 11dd 
                 5y 
               
               
                   
                 IV-262 
                 9d, 8k 
                 8q 
                 11ee 
                 5y 
               
               
                   
                 IV-263 
                 9d, 8k 
                 8q 
                 11ff 
                 5y 
               
               
                   
                 IV-264 
                 9d, 8k 
                 8q 
                 11gg 
                 5y 
               
               
                   
                   
               
             
          
         
       
     
         [0253]    Examples of a PSMA inhibitor bearing a polymer conjugate (PEG) 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    where n is 1-200, 100-200, 150-200, 1-100, 1-50, 1-10, or 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10. 
         [0254]    The invention compounds falling under the embodiments as disclosed above are not one or all of the following compounds in Table 1: 
         [0000]    
       
         
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
             
             
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                   18 F-S-2-((2-(S-4-(4-fluorobenzamido)- 4-carboxybutanamido)-S-2- carboxyethoxy)hydroxyphosphoryl- amino)-pentanedioic acid. 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{[(2S)-2-carboxy-2-({4-[({3-[(2- {[3-carboxy-4-(6-hydroxy-3-oxo- 9,9a-dihydro-3H-xanthen-9-yl) phenyl]amino}-2-oxoethyl)thio] propanoyl}amino)methyl]benzoyl} amino)ethoxy](hydroxy)phosphoryl}- L-glutamic acid;  
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-[{(2S)-2-carboxy-2-[(4-{[(6- {[3-carboxy-4-(6-hydroxy-3-oxo- 9,9a-dihydro-3H-xanthen-9-yl) benzoyl]amino}hexanoyl)amino] methyl}benzoyl)amino]ethoxy} (hydroxy)phosphoryl]-L-glutamic acid;  
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{3-[(2-{[3-carboxy-4-(6-hydroxy- 3-oxo-9,9a-dihydro-3H-xanthen- 9-yl)phenyl]amino}-2-oxoethyl) thio]propanoyl}-L-γ-glutamyl-O- [{[(1S)-1,3-dicarboxy- propyl]amino}(hydroxy) phosphoryl]-L-serine; 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-(6-{[3-carboxy-4-(6-hydroxy- 3-oxo-9,9a-dihydro-3H- xanthen-9-yl)benzoyl]amino}hexanoyl)- L-γ-glutamyl-O-[{[(1S)-1,3-dicarboxy- propyl]amino}(hydroxy)prosphoryl]- L-serine; 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-[{(2S)-2-carboxy-2-[({[3- carboxy-4-(6-hydroxy-3- oxo-9,9a-dihydro-3H-xanthen- 9-yl)phenyl]amino}carbonothioyl) amino]ethoxy}(hydroxy)phosphoryl]- L-glutamic acid; 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{[(4-{2-[bis(carboxymethyl) amino]-3-[{2-[bis(carboxy- methyl)amino]ethyl}(carboxymethyl) amino]propyl}phenyl)amino] carbonothioyl}-L-γ-glutamyl-O- [{[(1S)-1,3-dicarboxypropyl]amino} (hydroxy)phosphoryl]-L-serine; 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{6-[(6-{[5-(2-oxohexahydro- 1H-thieno[3,4-d]imidazol-4- yl)pentanoyl]amino}hexanoyl)amino] hexanoyl}-L-γ-glutamyl-O-[{[(1S)- 1,3-dicarboxypropyl]amino} (hydroxy)phosphoryl]-L-serine; 
               
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
                 N-{[(2S)-2-carboxy-2-({4-[({6- [(6-{[5-(2-oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)pentanoyl]amino}hexanoyl)amino] hexanoyl}amino)methyl]benzoyl} amino)ethoxy](hydroxy)phosphoryl}- L-glutamic acid 
               
               
                   
               
             
          
         
       
     
         [0255]    In an embodiment , the invention comprises the compound of formula (V), 
         [0000]    
       
                 
         
             
             
         
       
     
         [0000]    and pharmaceutically acceptable salts thereof, wherein R AA , L 1 , X, Y, R 3 , R 5 , R° , and R 10  are R AA  is hydrogen, C 1 -C 7 alkyl, aryl, heteroaryl, arylC 1 -C 7 alkyl, or heteroarylC 1 -C 7 alkyl, wherein the alkyl, arylalkyl, and heteroarylalkyl groups are optionally substituted with 1, 2, 3,4, or 5 R A1  groups, wherein each R A1  is independently —OR A2 , —N(R A2 ) 2 , —C(O)OR A2 , —C(O)N(R A2 ) 2 , —N(R A2 )C(═NR A2 )N(R A2 ) 2 , or C 1 -C 7 alkyl, wherein each R A2  is independently hydrogen or C 1 -C 1 alkyl. 
         [0256]    L 1  is one of groups (5u)-(5z) as defined above for formula (I). 
         [0257]    X and Y are one of groups (7a)-(7g) as defined above for formula (I). 
         [0258]    each R 3  is independently one of groups (9a)-(9e) as defined above for formula (II). 
         [0259]    R 5  is one of groups (8h)-(8i) as defined above for formula (I). 
         [0260]    each R 6  is independently one of groups (8m)-(8q) as defined above for formula (I). 
         [0261]    R 10  is -aryl-R 9 , -heteroaryl-R 9 , —C 1 -C 7 alkyl-aryl-R 9 , —C 1 -C 1 alkyl-heteroaryl-R 9 , —C 1 -C 7 alkyl-R 8 , -aryl-C 1 -C 7 alkyl-R 8 , or -heteroaryl-C 1 -C 7 alkyl-R 8 , wherein
           the aryl, heteroaryl, alkyl-aryl, aryl-alkyl, alkyl-heteroaryl, and heteroaryl-alkyl groups are optionally substituted with one, two, or three groups which are each independently halomethyl, dihalomethyl, trihalomethyl, —C(O)R 11 , —CO(O)R 12 , —C(O)N(R 12 ) 2 , wherein
               each R 11  is independently hydrogen, —C 1 -C 7  alkyl, —C 1 -C 7  alkylaryl, or —C 1 -C 7  alkylheteroaryl; and   each R 12  is independently R 11  or a protecting group;   
                       
 
         [0265]    In an embodiment of any of the preceding embodiments of formulae (I)-(VI), (IIa)-(IIe), (IIIa)-(IIIe), (IVa)-(IVe), (Va)-(Vc), and (VIa)-(VII), R 9  can be one of groups (12a)-(12o):
       (12a) a detectable label, or a cytotoxic group.   (12b) a detectable label.   (12c)  18 F.   (12d) biotin.   (12e) a cytotoxic group.   (12f) —N 3 , —C≡CH, —ONH 2 , —C(O)N(H)NH 2 , or —N(H)NH 2 .   (12g) —N 3  or —C≡CH.   (12h) —C≡CH,   (12i) —N 3 .   (12j) a pendant group comprising either a detectable label, or a cytotoxic group.   (12k) a pendant group comprising a detectable label.   (12l) a pendant group comprising a cytotoxic group.   (12m) a pendant group bonded to a solid support.       
 
         [0279]    Suitable detectable labels include, but are not limited to, fluorescent or dichroic dyes; bonded radionuclides; radioisotopes coordinated to a chelating moiety, such as chelated  99m Tc,  64 Cu,  68 Ga,  111 In, or  152 Gd; chelated MRI contrast agents, such as Gd, Mn, Ba, superparamagnetic iron oxide (SIPO)(e.g., 300-3500 nm, or 60-150 nm diameter particles), ultrasmall superparamagnetic iron oxide (USPIO)(e.g., 10-30 mn diameter particles); and chelated radiotherapeutics, such as  171 Lu or  90 Y. 
         [0280]    Radionuclides useful within the present invention include gamma-emitters, positron-emitters, Auger electron-emitters, X-ray emitters and fluorescence-emitters, with beta- or alpha-emitters preferred for therapeutic use. Examples of useful radionuclides include:  18 F,  32 P,  33 P,  43 K,  47 Sc,  52 Fe,  57 Co,  64 Cu,  67 Ga,  67 Cu,  68 Ga,  71 Ge,  75 Br,  76 Br,  77 Br,  77 As,  77 Br,  81 Rb,  81m Kr,  87m Sr,  90 Y,  97 Ru,  99m Tc,  100 Rh,  101 Rh,  103 Pb,  105 Rh,  109 Pd,  111 Ag,  111 In,  113 In,  119 Sb,  121 Sb,  123 I,  125 I,  127 Cs,  128 Ba,  129 Cs,  131 I,  131 Cs,  143 Pr,  153 Sm,  161 Tb,  166 Ho,  169 Eu,  177 In,  136 Re,  188 Re,  189 Re,  191 Os,  193 Pt,  194 Ir,  197 Hg,  199 Au,  203 Pb,  211 At,  212 Pb,  212 Bi and  213 Bi. 
         [0281]    In certain embodiments, the detectable label can be a bonded radionuclide. In one embodiment, the radionuclide is  18 F,  123 I,  124 I,  125 , or  131 I. 
         [0282]    When R 9  is a radiotisotope, it can be coordinated to a chelating moiety, such as chelated  99m Te,  64 Cu,  68 Ga, or  111 In. In certain embodiments, R 9  is  99m Te coordinated to a chelating moiety. Moieties which can serve as chelating ligands, include, for example MAG 3 (mercaptoacetyltriglycine) or bispicolylamine (SAAC); derivatives of 1,4,7,10-tetraazacyclododecanetetraacetie acid (DOTA), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA) and 1-p-Isothiocyanato-benzyl-methyl-diethylenetriaminepentaacetic acid (ITC-MX). These chelators typically have groups on the side chain by which the chelator can be used for attachment to a parent molecule. Such groups include, e.g., benzylisothiocyanate, by which the MAG 3, SAAC. DTPA, NOTA, CHX-A′ or EDTA can be coupled to, e.g., an amine group of the parent molecule. 
         [0283]    In another embodiment, the  18 F in the  18 F-containing structures displayed hereinabove can be replaced with another radionuclide disclosed herein. 
         [0284]    Suitable cytotoxic groups include, but are not limited to, chelated or bonded radiotherapeutics, photosensitizers, small molecule agents such as paclitaxel, camptothecin, and doxorubicin, as well as lysosomal disrupting agents, such as,  125 I,  131 I,  177 Lu,  168 Rh, or  90 Y. 
         [0285]    An example of a  18 F-labeled peptide analog of CTT-54 which could be made is a pharmaceutically acceptable salt of, 
         [0000]    
       
                 
         
             
             
         
       
     
         [0286]    Exemplary cold compounds which could be 18F labeled were examined using the assay described in U.S. Pat. No. 7,696,185 to Berkman which is herein incorporated by reference. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0287]    These results are consistent with those observed for the SFB-CTT-54 conjugate initially described in “Assessment of an  18 F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer”. Lapi, S. E., et al.,  J. Nucl. Med.  2009, 50(12), 2042-8, which is hereby incorporated by reference in its entirety. The heteroatomic ring (nicotinamide) did not diminish the PSMA binding observed for the SFB-CTT-54. Unexpectedly, the IC 50  for the fluoronicotinamide (LW-4-48) was found to be 0.6 nM, an approximately three-fold improvement over the preceding fluorobenzamide (SFB-CTT-54). 
       DEFINITIONS 
       [0288]    A “polypeptide of 1-20 amino acids” as used herein means a linear polypeptide wherein each of the amino acids are naturally occurring or non-naturally occurring (e.g., D-amino acids, beta amino acids, beta and gamma-linked aspartate and glutamate). In certain embodiments, each of the amino acids is naturally occurring (L-amino acids). For example, a polypeptide can have the following structure, [N(R N )—C(H)(R A )—C(O)] r —, wherein
       —C(O)R 10  is connected to the N-terminus;   r is selected from 1 to 20;   each R A  is independently hydrogen, C 1 -C 7 alkyl, aryl, heteroaryl, arylC 1 -C 7 alkyl, or heteroarylC 1 -C 7 alkyl, wherein the alkyl, arylalkyl, and heteroarylalkyl groups are optionally substituted with 1, 2, 3, 4, or 5 R A10  groups, wherein each R A10  is independently —OR A20 , —SR A20 , —N(R A20 ) 2 , —C(O)OR A20 , —C(O)N(R A2 ) 2 , —N(R A20 )C(═NR A2 )N(R A20 ) 2 , or C 1 -C 7 alkyl, wherein each R A20  is independently hydrogen or C 1 -C 7 alkyl; and   each R N  is hydrogen,   or any R A  and R N  within the same subunit can be taken together with the atoms to which they are attached to faun a 5 membered heterocyclyl.       
 
         [0294]    “Protecting groups” include, but are not limited to substituted benzyl, t-butyl ester, alkyl esters (e.g., methyl, ethyl), and fluorenylmethoxycarbonyl groups as described in Greene&#39;s Protective Groups in Organic Synthesis, 4th Edition for protecting groups of carboxylic and phosphorus acids. Substituted benzyl groups include, but are not limited to, triphenylmethyl (trityl), diphenylmethyl, o-nitrobenzyl, 2,4,6-trimethylbenzyl, p-brornobenzyl, p-nitrobenzyl, p-methoxybenzyl, 2,6-d imethoxybenzyl, 4-(methyl sul finyl)benzyl, 4-sul fobenzyl, 4-azidomethoxybenzyl, and piperonyl, and other teachings relating to carboxylate protecting groups of Greene&#39;s Protective Groups in Organic Synthesis (included, without limitation, the identity of such groups and methods of their use) is hereby incorporated by reference in their entirety. 
         [0295]    A “pendant group” as used herein means a group of the formula, 
         [0000]      —(C 0 -C 10  alkyl-D) 0-1 -C 0 -C 10  alkyl-,
 
         [0000]    wherein D is a bond, aryl, heteroaryl, C 3 -C 8  cycloalkyl, or heterocyclyl; and no more than one methylene in each alkyl group is optionally and independently replaced by —O—, —S—, —N(R 00 )—, —C(H)═C(H)—, —C≡C—, —C(O)—, —S(O)—, —S(O) 2 —, —P(O)(OH)—, —OP(O)(OH)—, —P(O)(OH)O—, —N(R 00 P(O)(OH)—, —P(O)(OH)N(R 00 )—, —OP(O)(OH)O—, —OP (O)(OH)N(R 00 )—, —N(R 00 )P(O)(OH)O—, —N(R 00 )P(O)(OH)N(R 00 )—, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —S(O)O—, —OS(O)—, —S(O)N(R 00 )—, —N(R 00 )S(O)—, —S(O) 2 O—, —OS(O) 2 —, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, —N(R 00 )C(O)N(R 00 )—, —OS(O)O—, —OS(O)N(R 00 )—, —N(R 00 )S(O)O—, —N(R 00 )S(O)N(R 00 )—, —OS(O) 2 O—, —OS(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 O—, or —N(R 00 )S(O) 2 N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl. 
         [0296]    Particular embodiments of a “pendant group” as used herein include groups of the formula, 
         [0000]      —(C 0 -C 10  alkyl-D) 0-1 -C 0 -C 10  alkyl-,
 
         [0000]    wherein
   (1) D is aryl, heteroaryl, C 3 -C 8  cveloalkyl, or heterocyclyl; and no more than one methylene in each alkyl group is optionally and independently replaced by —O—, —S—, —N(R 00 )—, —C(H)═C(H)—, —C≡C—, —C(O)—, —S(O)—, —S(O) 2 —, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —S(O) 2 O—, —OS(O) 2 —, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, —OC(O)O—, —OC(O)N(R 00 —, —N(R 00 )C(O)O—, —N(R 00 )C(O)N(R 00 )—, —OS(O) 2 O—, —OS(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 O—, or —N(R 00 )S(O) 2 N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl;   or   (2) D is aryl or heteroaryl; and no more than one methylene in each alkyl group is optionally and independently replaced by —O—, —S—, —N(R 00 )—, —C(H)═C(H)—, —C≡C—, —C(O)—, —S(O)—, —S(O) 2 —, —O(O)O—, —C(O))N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, or —N(R 00 )C(O)N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl;   or   (3) D is aryl or heteroaryl; and no more than one methylene in each alkyl group is optionally and independently replaced by —O—, —S—, —N(R 00 )—, —C(O)—, —S(O) 2 —, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, or —N(R 00 )C(O)—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl.   
 
         [0302]    Particular embodiments of a “pendant group” also includes a group of the formula, 
         [0000]      —C 0 -C 10  alkyl-,
 
         [0000]    wherein no more than one methylene in the alkyl group is optionally replaced by —O—, —S—, —N(R 00 )—, —C(H)═C(H)—, —C≡C—, —C(O)—, —S(O)—, —S(O) 2 —, —P(O)(OH)—, —OP(O)(OH)—, —P(O)(OH)O—, —N(R 00 )P(O)(OH)—, —P(O)(OH)N(R 00 )—, —OP(O)(OH)O—, —OP(O)(OH)N(R 00 )—, —N(R 00 )P(O)(OH)O—, —N(R 00 )P(O)(OH)N(R 00 )—, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —S(O)O—, —OS(O)—, —S(O)N(R 00 )—, —N(R 00 )S(O)—, —S(O) 2 O—, —OS(O) 2 —, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, —N(R 00 )C(O)N(R 00 )—, —OS(O)O—, —OS(O)N(R 00 )—, —N(R 00 )S(O)O—, —N(R 00 )S(O)N(R 00 )—, —OS(O) 2 O—, —OS(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 O—, or —N(R 00 )S(O) 2 N(R 00 )— wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl. 
         [0303]    Particular embodiments of a “pendant group” also includes a group of the formula, 
         [0000]      —C1-C 10  alkyl-,
   wherein   (1) no more than one methylene in the alkyl group is optionally replaced by —O—, —S—, —N(R 00 )—, —O(O)—, S(O) 2 —, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, —OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, or —N(R 00 )C(O)N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl;   or (2) no more than one methylene in the alkyl group is optionally replaced by —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, or —N(R 00 )C(O)N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl;   or (3) no more than one methylene in the alkyl group is optionally replaced by —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, or —N(R 00 C(O)—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl.   
 
         [0308]    Particular embodiments of a “pend ant group” also includes a group of the formula, 
         [0000]      -J-C 0 -C 10  alkyl-,   wherein   (1) J is —O—, —S—, —N(R 00 )—, —C(H)═C(H)—, —C≡C—, —C(O)—, —S(O)—, —S(O) 2 —, —P(O)(OH)—, —OP(O)(OH)—, —P(O)(OH)O—, —N(R 00 )P(O)(OH)—, —P(O)(OH)N(R 00 )—, —OP(O)(OH)O—, —OP(O)(OH)N(R 00 )—, —N(R 00 )P(O)(OH)O—, —N(R 00 )P(O)(OH)N(R 00 )—, —C(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —S(O)O—, —S(O)—, —S(O)N(R 00 )—, —N(R 00 )S(O)—, —S(O) 2 O—, —OS(O) 2 —, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, —N(R 00 )C(O)N(R 00 )—, —OS(O)O—, —OS(O)N(R 00 )—, —N(R 00 )S(O)O—, —N(R 00 )S(O)N(R 00 )—, —OS(O) 2 O—, —OS(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 O—, or —N(R 00 )S(O) 2 N(R 00 )—, wherein each R 0   0  is independently hydrogen or C 1 -C 7  alkyl, and wherein J is bonded to the moiety substituted by the pendant group;   or (2) J is —O—, —S—, —N(R 00 )—, —C(O)—, S(O) 2 —, —C(O)O—, —C(O)N(R 00 )—, —CO(O)—, —N(R 00 )C(O)—, —S(O) 2 N(R 00 )—, —N(R 00 )S(O) 2 —, —OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, or —N(R 00 )C(O)N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C 2  alkyl, and wherein J is bonded to the moiety substituted by the pendant group;   or (3) J is —O(O)O—, —C(O)N(R 00 )—, —OC(O)—, —N(R 00 )C(O)—, —OC(O)O—, —OC(O)N(R 00 )—, —N(R 00 )C(O)O—, or —N(R 00 )C(O)N(R 00 )—, wherein each R 00  is independently hydrogen or C 1 -C- 7  alkyl, and wherein J is bonded to the moiety substituted by the pendant group;   or (4) J is —O(O)O—, —C(O)N(R 00 )—, —OC(O)—, or —N(R 00 )C(O)—, wherein each R 00  is independently hydrogen or C 1 -C 7  alkyl, and wherein J is bonded to the moiety substituted by the pendant group; or (5) 7 is —C(O)N(R 00 )— or —N(R 00 )C(O)—, wherein R 00  is hydrogen or C 1 -C 7  alkyl, and wherein J is bonded to the moiety substituted by the pendant group.     
         [0314]    Particular embodiments of a “pendant group” also includes a group of the formula, —C(O)N(R 00 )—C 0 -C 10  alkyl-, wherein R 00  is hydrogen or C 1 -C 7  alkyl, and wherein the amide carbonyl is bonded to the moiety substituted by the pendant group. 
         [0315]    Particular embodiments of a “pendant group” also includes a group of the formula,) —N(R 00 )C(O)—C 0 -C 12  alkyl-, wherein R 00  is hydrogen or C 1 -C 7  alkyl, and wherein the amide nitrogen is bonded to the moiety substituted by the pendant group. 
         [0316]    A “pendant group comprising a detectable label, or a cytotoxic group” as used herein means a group of the formula -L-R 0  wherein L is any of the preceding pendant groups as defined herein and R 0  is a detectable label, or a cytotoxic group, each as defined above. 
         [0317]    A “pendant group bonded to a solid support” as used herein means a group of the formula, -L-R 0 , wherein L is any of the preceding pendant groups, as defined herein, and R 0  is the surface of a solid support. Examples of solid supports include, but are not limited to, a resin, a polymer, or a silica. 
         [0318]    The term “alkyl” as used herein, means a straight or branched chain hydrocarbon containing from 1 to 10 carbon atoms, unless otherwise specified. Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl tert-butyl, n-pentyl, isopentyl, neop en t yl, n-hexyl, 3-methylhexyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, n-heptyl, n-octyl, n-nonyl, and n-decyl. When an “alkyl” group is a linking group between two other moieties, then it may also be a straight or branched chain; examples include, but are not limited to —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CHC(CH 3 )—, —CH 2 CH(CH 2 CH 3 )CH 2 —. 
         [0319]    The term “aryl,” as used herein, means a phenyl (i.e., monocyclic aryl), or a bicyclic ring system containing at least one phenyl ring or an aromatic bicyclic ring containing only carbon atoms in the aromatic bicyclic ring system. The bicyclic aryl can be azulenyl, naphthyl, or a phenyl fused to a monocyclic cycloalkyl, a monocyclic cycloalkenyl, or a monocyclic hetcrocyclyl. The bicyclic aryl is attached to the parent molecular moiety through any carbon atom contained within the phenyl portion of the bicyclic system, or any carbon atom with the napthyl or azulenyl ring. The fused monocyclic cycloalkyl or monocyclic heterocyclyl portions of the bicyclic aryl are optionally substituted with one or two oxo and/or thia groups. Representative examples of the bicyclic aryls include, but are not limited to, azulenyl, naphthyl, dihydroinden-1-yl, dihydroinden-2-yl, dihydroindcn-3-yl, dihydroinden-4-yl, 2,3-dihydroindol-4-yl, 2,3-dihydroindol-5-yl, 2,3-dihydroindol-6-yl, 2,3-dihydroindol-7-yl, inden-1-yl, inden-2-yl, inden-3-yl, inden-4-yl, dihydronaphthalen-2-yl, dihydronaphthalen-3-yl, dihydronaphthalen-4-yl, dihydronaphthalen-1-yl, 5,6,7,8-tetrahydronaphthalen-1-yl, 5,6,7,8-tetrahydronaphthalen-2-yl, 2,3-dihydrobenzo 2,3-dihydrobenzofuran-5-yl, 2,3-dihydrobenzofuran-6-yl, 2,3-dihydrobenzofuran-7-yl, benzo[d][1,3]dioxol-4-yl, benzo[d][1,3]dioxol-5-yl, 2H-chromen-2-on-5-yl, 2H-chromen-2-on-6-yl, 2H-chromen-2-on-7-yl, 2H-chromen-2-on-8-yl, isoindoline-1,3-dion-4-yl, isoindoline-1,3-dion-5-yl, inden-1-on-4-yl, inden-1-on-5-yl, inden-1-on-6-yl, inden-1-on-7-yl, 2,3-dihydrobenzo[b][1,4]dioxan-5-yl, 2,3-dihydrobenzo[b][1,4]dioxan-6-yl, 2H-benzo[b][1,4]oxazin3(4H)-on-5-yl, 2H-benzo[b][1,4]oxazin3 (4H)-on-6-yl, 2H-benzo[b][1,4]oxazin3(4H)-on-7-yl, 2H-benzo[b][1,4]oxazin3 (4H)-on-8-yl, benzo[d]oxazin-2(3H)-on-5-yl, benzo[d]oxazin-2(3H)-on-6-yl, benzo[d]oxazin-2(3H)-on-7-yl, benzo[d]oxazin-2(3H)-on-8-yl, quinazolin-4(3H)-on-5-yl, quinazolin-4(3H)-on-6-yl, quinazolin-4(3H)-on-7-yl, quinazolin-4(3H)-on-8-yl, quinoxalin-2(1H)-on-5-yl, quinoxalin-2(1H)-on-6-yl, quinoxalin-2(1H)-on-7-yl, quinoxalin-2(1H)-on-8-yl, benzo[d]thiazol-2(3H)-on-4-yl, benzo[d]thiazol-2(3H)-on-5-yl, benzo[d]thiazol-2(3H)-on-6-yl, and, benzo[d]thiazol-2(3H)-on-7-yl. In certain embodiments, the bicyclic aryl is (i) naphthyl or (ii) a phenyl ring fused to either a 5 or 6 membered monocyclic cycloalkyl, a 5 or 6 membered monocyclic cycloalkenyl, or a 5 or 6 membered monocyclic heterocyclyl, wherein the fused cycloalkyl, cycloalkenyl, and heterocyclyl groups are optionally substituted with one or two groups which are independently oxo or thia. 
         [0320]    The term “arylalkyl” and “-alkylaryl” as used herein, means an aryl group, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of arylalkyl include, but are not limited to, benzyl, 2-phenylethyl, 3-phenylpropyl, and 2-naphth-2-ylethyl. 
         [0321]    The term “cycloalkyl” as used, herein, means a monocyclic or a bicyclic cycloalkyl ring system. Monocyclic ring systems are cyclic hydrocarbon groups containing from 3 to 8 carbon atoms, where such groups can be saturated or unsaturated, but not aromatic. In certain embodiments, cycloalkyl groups are fully saturated. Examples of monocyclic cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, and cyclooctyl. Bicyclic cycloalkyl ring systems are bridged monocyclic rings or fused bicyclic rings. Bridged monocyclic rings contain a monocyclic cycloalkyl ring where two non-adjacent carbon atoms of the monocyclic ring are linked by an alkylene bridge of between one and three additional carbon atoms (i.e., a bridging group of the form —(CH 2 ) w —, where w is 1, 2, or 3). Representative examples of bicyclic ring systems include, but are not limited to, bicyclo[3.1.1]heptane, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.2]uonane, bicyclo[3.3.1]nonanc, and bicyclo[4.2.1]nonane. Fused bicyclic cycloalkyl ring systems contain a monocyclic cycloalkyl ring fused to either a phenyl, a monocyclic cycloalkyl, a monocyclic cycloalkenyl, a monocyclic heterocyclyl, or a monocyclic heteroaryl. The bridged or fused bicyclic cycloalkyl is attached to the parent molecular moiety through any carbon atom contained within the monocyclic cycloalkyl ring. Cycloalkyl groups arc optionally substituted with one or two groups which are independently oxo or thia. In certain embodiments, the fused bicyclic cycloalkyl is a 5 or 6 membered monocyclic cycloalkyl ring fused to either a phenyl ring, a 5 or 6 membered monocyclic cycloalkyl, a 5 or 6 membered monocyclic cycloalkenyl, a 5 or 6 membered monocyclic heterocyclyl, or a 5 or 6 membered monocyclic heteroaryl, wherein the fused bicyclic cycloalkyl is optionally substituted by one or two groups which are independently oxo or thia. 
         [0322]    “Cycloalkenyl” as used herein refers to a monocyclic or a bicyclic cycloalkenyl ring system. Monocyclic ring systems are cyclic hydrocarbon groups containing from 3 to 8 carbon atoms, where such groups are unsaturated (i.e., containing at least one annular carbon-carbon double bond), but not aromatic. Examples of monocyclic ring systems include cyclopentenyl and cyclohexenyl. Bicyclic cycloalkenyl rings are bridged monocyclic rings or a fused bicyclic rings. Bridged monocyclic rings contain a monocyclic cycloalkenyl ring where two non-adjacent carbon atoms of the monocyclic ring are linked by an alkylene bridge of between one and three additional carbon atoms (i.e., a bridging group of the form —(CH 2 ) w —, where w is 1, 2, or 3). Representative examples of bicyclic cycloalkenyls include, but are not limited to, norbornyl and bicyclo[2.2.2]oct-2-enyl. Fused bicyclic cycloalkenyl ring systems contain a monocyclic cycloalkenyl ring fused to either a phenyl, a monocyclic cycloalkyl, a monocyclic cycloalkenyl, a monocyclic heterocyclyl, or a monocyclic heteroaryl. The bridged or fused bicyclic cycloalkenyl is attached to the parent molecular moiety through any carbon atom contained within the monocyclic cycloalkenyl ring. Cycloalkenyl groups are optionally substituted with one or two groups which are independently oxo or thia. 
         [0323]    The term “halo” or “halogen” as used herein, means —Cl, —Br, —I or —F. 
         [0324]    The term “haloalkyl” as used herein, means at least one halogen, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of haloalkyl include, but are not limited to, chloromethyl, 2-fluoroethyl, trifluoromethyl, pentafluoroethyl, and 2-chloro-3-fluoropentyl. 
         [0325]    The term “haloalkylcarbonyloxy” as used herein means a group of the formula —OC(O)R, where R is a haloalkyl group as defined herein. 
         [0326]    The term “heteroaryl,” as used herein, means a monocyclic heteroaryl or a bicyclic ring system containing at least one heteroaromatic ring. The monocyclic heteroaryl can be a 5 or 6 membered ring. The 5 membered ring consists of two double bonds and one, two, three or four nitrogen atoms and optionally one oxygen or sulfur atom. The 6 membered ring consists of three double bonds and one, two, three or four nitrogen atoms. The 5 or 6 membered heteroaryl is connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the heteroaryl. Representative examples of monocyclic heteroaryl include, but are not limited to, furyl, imidazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, oxazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrazolyl, pyrolyl, tetrazolyl, thiadiazolyl, thiazolyl, thienyl, triazolyl, and triazinyl. The bicyclic heteroaryl consists of a monocyclic heteroaryl fused to a phenyl, a monocyclic cycloalkyl, a monocyclic cycloalkenyl, a monocyclic heterocyclyl, or a monocyclic heteroaryl. The fused cycloalkyl or heterocyclyl portion of the bicyclic heteroaryl group is optionally substituted with one or two groups which are independently oxo or thia. When the bicyclic heteroaryl contains a fused cycloalkyl, cycloalkenyl, or heterocyclyl ring, then the bicyclic heteroaryl group is connected to the parent molecular moiety through any carbon or nitrogen atom contained within the monocyclic heteroaryl portion of the bicyclic ring system. When the bicyclic heteroaryl is a monocyclic heteroaryl fused to a phenyl ring, then the bicyclic heteroaryl group is connected to the parent molecular moiety through any carbon atom or nitrogen atom within the bicyclic ring system. Representative examples of bicyclic heteroaryl include, but are not limited to, benzimidazolyl, benzofuranyl, benzothienyl, benzoxadiazolyl, benzoxathiadiazolyl, benzothiazolyl, cinnolinyl, 5,6-dihydroquinolin-2-yl, 5,6-dihydroisoquinolin-1-yl, furopyridinyl, indazolyl, indolyl, isoquinolinyl, naphthyridinyl, quinolinyl, purinyl, 5,6,7,8-tetrahydroquinolin-2-yl, 5,6,7,8-tetrahydroquinolin-3-yl, 5,6,7,8-tetrahydroquinol 5,6,7,8-tetrahydroisoquinolin-1-yl, thienopyridinyl, tetrahydrobenzo[c][1,2,5]oxadiazolyl, and 6,7-dihydrobenzo[c][1,2,5]oxadiazol-4(5H)-onyl. In certain embodiments, the fused bicyclic heteroaryl is a 5 or 6 membered monocyclic heteroaryl ring fused to either a phenyl ring, a 5 or 6 membered monocyclic cycloalkyl, a 5 or 6 membered monocyclic cycloalkenyl, a 5 or 6 membered monocyclic heterocyclyl, or a 5 or 6 membered monocyclic heteroaryl, wherein the fused cycloalkyl, cycloalkenyl, and heterocyclyl groups are optionally substituted with one or two groups which are independently oxo or thia. 
         [0327]    The term “heteroarylalkyl” and “-alkylheteroaryl” as used herein, means a heteroaryl, as defined herein, appended to the parent molecular moiety through an alkyl group, as defined herein. Representative examples of heteroarylalkyl include, but are not limited to, fur-3-ylmethyl, 1H-imidazol-2-ylmethyl, 1H-imidazol-4-ylmethyl, 1-(pyridin-4-yl)ethyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl, pyrimidin-5-ylmethyl, 2-(pyrimidin-2-yl)propyl, thien-2-ylmethyl, and thien-3-ylmethyl. 
         [0328]    The term “heterocyclyl” as used herein, means a monocyclic heterocycle or a bicyclic heterocycle. The monocyclic heterocycle is a 3, 4, 5, 6 or 7 membered ring containing at least one heteroatom independently selected from the group consisting of O, N, and S where the ring is saturated or unsaturated, but not aromatic. The 3 or 4 membered ring contains 1 heteroatom selected from the group consisting of O, N and S. The 5 membered ring can contain zero or one double bond and one, two or three heteroatoms selected from the group consisting of O, N and S. The 6 or 7 membered ring contains zero, one or two double bonds and one, two or three heteroatoms selected from the group consisting of O, N and S. The monocyclic heterocycle is connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the monocyclic heterocycle. Representative examples of monocyclic heterocycle include, but are not limited to, azctidinyl, azepanyl, aziridinyl, diazepanyl, 1,3-dioxanyl, 1,3-dioxolanyl, 1,3-dithiolanyl, imidazolinyl, isothiazolinyl, isothiazolidinyl. isoxazolinyl, isoxazolidinyl, morpholinyl, oxadiazolinyl, oxazolinyl, oxazolidinyl, piperazinyl, piperidinyl, pyranyl, pyrazolinyl, pyrazolidinyl, pyrrolinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, thiadiazolinyl, thiadiazolidinyl, tluazolinyl, thiazolidinyl, thionicapholinyl, 1,1-dioxidothiomorpholinyl (thiomorpholine sulfone), thiopyranyl, and trithianyl. The bicyclic heterocycle is a monocyclic heterocycle fused to either a phenyl, a monocyclic cycloalkyl, a monocyclic cycloalkenyl, a monocyclic heterocycle, or a monocyclic heteroaryl. The bicyclic heterocycle is connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the monocyclic heterocycle portion of the bicyclic ring system. Representative examples of bicyclic heterocyclyls include, but are not limited to, 2,3-dihydrobenzofuran-2-yl, 2,3-dihydrobenzofizan-3-yl, indolin-1-yl, indolin-2-yl, indolin-3-yl, 2,3-clihydrobenzothien-2-yl, decahydroquinolinyl, decahydroisoquinolinyl, octahydro-1H-indolyl, and octahydrobenzofuranyl. Fleterocyclyl groups arc optionally substituted with one or two groups which are independently oxo or thia. In certain embodiments, the bicyclic heterocyclyl is a 5 or 6 membered monocyclic heterocyclyl ring fused to phenyl ring, a 5 or 6 membered monocyclic cycloalkyl, a 5 or 6 membered monocyclic cycloalkenyl, a 5 or 6 membered monocyclic heterocyclyl, or a 5 or 6 membered monocyclic heteroarvl, wherein the bicyclic heterocyclyl is optionally substituted by one or two groups which are independently oxo or thia. 
         [0329]    The term “oxo” as used herein means a ═O group. 
         [0330]    The term “saturated” as used herein means the referenced chemical structure does not contain any multiple carbon-carbon bonds. For example, a saturated cycloalkyl group as defined herein includes cyclohexyl, cyclopropyl, and the like. 
         [0331]    The terra “thia” as used herein means a ═S group. 
         [0332]    The term “unsaturated” as used herein means the referenced chemical structure contains at least one multiple carbon-carbon bond, but is not aromatic. For example, a unsaturated cycloalkyl group as defined herein includes cyclohexenyl, cyclopentenyl, cyclohexadienyl, and the like, 
         [0333]    As used herein, the term “cell” is meant to refer to a cell that is in vitro, ex vivo or in vivo. In some embodiments, an ex vivo cell can be part of a tissue sample excised from an organism such as a mammal. In some embodiments, an in vitro cell can be a cell in a cell culture, In some embodiments, an in vivo cell is a cell living in an organism such as a mammal. 
         [0334]    As used herein, the term “contacting” refers to the bringing together of indicated moieties in an in vitro system or an in vivo system. For example, “contacting” PSMA with a compound includes the administration of a compound described herein to an individual or patient, such as a human, as well as, for example, introducing a compound into a sample containing a cellular or purified preparation containing PMSA. 
         [0335]    As used herein, the term “individual” or “patient,” used interchangeably, refers to any animal, including mammals, preferably mice, rats, other rodents, rabbits, dogs, cats, swine, cattle, sheep, horses, or primates, and most preferably humans. 
         [0336]    As used herein, the phrase “therapeutically effective amount” refers to the amount of active compound or pharmaceutical agent that elicits the biological or medicinal response that is being sought in a tissue, system, animal, individual or human by a researcher, veterinarian, medical doctor or other clinician, which includes one or more of the following, as the case may be:
       (1) preventing the disease; for example, preventing a disease, condition or disorder in an individual who may be predisposed to the disease, condition or disorder but does not yet experience or display the pathology or symptomatology of the disease;   (2) inhibiting the disease; for example, inhibiting a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder; and   (3) ameliorating the disease; for example, ameliorating a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder (i.e., reversing the pathology and/or symptomatology) such as decreasing the severity of disease.
 
Whether the therapeutically effective amount is for prevention, inhibitions, or amelioration will be clear from the context.
       
 
         [0340]    As used here, the terms “treatment” and “treating” means ameliorating the referenced disease state, for example, ameliorating a disease, condition or disorder in an individual who is experiencing or displaying the pathology or symptomatology of the disease, condition or disorder (i.e., reversing or improving the pathology and/or symptomatology) such as decreasing the severity of disease. 
         [0341]    As used herein, the phrase “pharmaceutically acceptable salt” refers to both pharmaceutically acceptable acid and base addition salts and solvates. Such pharmaceutically acceptable salts include salts of acids such as hydrochloric, phosphoric, hydrobromic, sulfuric, sullinic, formic, toluenesulfonic, methanesulfonic, nitric, benzoic, citric, tartaric, maleic, hydroiodic, alkanoic such as acetic, HOOC—(CH 2 ) n —COOH where n is 0-4, and the like. Non-toxic pharmaceutical base addition salts include salts of bases such as sodium, potassium, calcium, ammonium, and the like. Those skilled in the art will recognize a wide variety of non-toxic pharmaceutically acceptable addition salts. 
       EXAMPLES 
     Example 1 
     Synthesis of Cold F19 PSMA Inhibitor 
       [0342]    
       
                 
         
             
             
         
       
     
         [0343]    The precursor (8.9 mg, 0.00875 mmol) was dissolved in THU (2 drops) and ethanol (400 μL). A suspension of 10% Pd/C (10.9 mg/800 μL in ethanol (200 μL) and 0.0256 mmol of KHCO 3  was added (25 μL of a 54.3 mg/250 μL solution), Ammonium formate (31 mg/200 μL water, 0.49 mmol) was added to initiate the reaction. The reaction was stirred at room temperature (without a cap) for 20 min, which was complete by TLC. The reaction mixture was filtered through a 0.2 μm PTFF. Whatman disc and flushed through with a mixture of ethanol: water (9:1 vol:vol ratio). The reaction mixture was evaporated to dryness and the product confirmed by  1 H and  31 P NMR. 
       Example 2 
     Pendant Group-Bearing Precursors of PSMA Inhibitors for Indirect Labeling with  18 F 
       [0344]    PSMA inhibitors can be outfitted with a motif that could be used in click chemistry or biorthogonal click chemistry (such as the Staudinger ligation, azide-alkyne Huisgen cycloaddition, Diels-Alder, or hydrazone formation) to couple to a detectable group (fluorescent dye, covalently attached radionuclide such as  18 F or  123 I, a chelated radioisotope such as  99m Tc,  64 Cu,  68 Ga or  111 In, a chelated MRI contrast agent, or therapeutic agent including chelated and covalently bonded radiotherapeutics such as  177 Lu,  90 Y,  125 I,  131 I, or cytotoxic drugs like doxorubicin, camptothecin, or paclitaxel. Examples of some click chemistry handles are shown below on the CTT-54 scaffold. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0345]    Indirect 18F-radiolabeling of PSMA inhibitors such as CTT-54 can be achieved, for example, by reacting PSMA inhibitors with amine-reactive radiolabeled prosthetic groups such as N-Succiairoidyl-4-18F-Fluorobenzoate or 6-[18F]fluoronicotinic acid tetrafluorophenyl ester. See, Lapi, S. E., et al., Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer. J. Nucl Med, 2009. 50(12): p. 2042-8, and Olberg, D. E., et al., One step radiosynthesis of 6-[(18)F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester ([(18)F]F-Py-TFP): a new prosthetic group for efficient labeling of biomolecules with fluorine-18. J Med Chem. 53(4): p. 1732-40, both of which are herein incorporated by reference. 
         [0346]    Two alternative routes of indirect labeling which are applicable to the compounds of the present invention, including without limitation to protected or deprotected pyridine derivatives, are presented below. 
         [0000]    
       
                 
         
             
             
         
       
       
                 
         
             
             
         
       
     
       Example 3 
     Preparation of Authentic Standards 
       [0347]    For the single substituted nicotinamide model compounds, an authentic standard was prepared as the 6-fluoronieotinamide analog. To prepare for the labeling of the tosyloxyethylcarbamoyl benzamide from  FIG. 1 , we completed the preparation of the cold authentic standard as shown below. 
         [0000]    
       
                 
         
             
             
         
       
     
       Example 4 
       99m Tc-Labeling Experiments 
       [0348]    Chelate conjugates of CTT-54 have recently been examined for the labeling of PSMA+ cells using  89m Tc as the guest radionuclide in the chelate structure. The rationale for these studies is to prepare for the development of alternative payloads for PET imaging ( 68 Ga or  64 Cu) and radiotherapy.  99m Tc serves as a model radionuclide for biodistribution studies. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0349]    Both LNCaP (PSIvIA+) and PC3 (PSMA−) cells were treated with DTPA-SCN-CTT-54 labeled with pertechnetate ( 99m TeO 4   − ) reduced with SnCl 2 . At increasing time points at 37° C., cells were washed free of the probe and uptake was determined as a percentage of the total amount of probe applied. Uptake was exclusive for LNCaP cells as shown in  FIG. 2 . Similarly, cells were treated with DTPA-SCN-CTT-54 labeled with  99m Tc(CO) 3  and the data shown in  FIG. 3 . Preliminary studies to determine the extent of internalization of the probe were completed and the results suggest that greater than 80% internalization (See, Table 4). 
         [0000]    
       
         
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                 Time  
                 % uptake 
                 % internalization 
               
               
                   
               
             
             
               
                 30 min  
                 2.30 
                 71.9 
               
               
                 2 hr 
                 2.94 
                 71.0 
               
               
                 4 hr 
                 2.34 
                 79.5 
               
               
                   
               
             
          
         
       
     
         [0350]    Our data suggests that binding to the cell surface happens rapidly (within 30 min), which is followed by rapid internallization (greater than 70% within 30 min). 
         [0351]    Competitive Binding Experiments. To confirm that the uptake of the probe was due to PSMA binding, cells were preincubated with the unlabeled inhibitor core C1T-54 for 30 min prior to incubation of the probe for 2 hours. In a dose-dependent manner, as shown in Table 5, CTT-54 blocked the binding of the radiolabeled probe. 
         [0000]    
       
         
               
               
               
             
               
               
               
             
           
               
                   
                 TABLE 5 
               
               
                   
                   
               
               
                   
                 Concentration (nM) 
                 % Uptake 
               
               
                   
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 0 
                 4.46 
               
               
                   
                 0.5 
                 2.80 
               
               
                   
                 5 
                 1.26 
               
               
                   
                 50  
                 0.38 
               
               
                   
                 500 
                 0.26 
               
               
                   
                   
               
             
          
         
       
     
         [0352]    Biodistribution Studies. Both PSMA+ (LNCaP) and PSMA− (PC3) tumor xenografts were implanted in opposite rear flanks of each mouse. Thus, each mouse served as both a positive and negative control. In biodistribution studies with the  99m Tc-labeled probe, substantial uptake was observed in the LNCaP PSMA+ tumor xenozrafts.