Abstract:
A frequency swept laser source that generates an optical signal that is tuned over a spectral scan band at single discrete wavelengths associated with longitudinal modes of the swept laser source. Laser hopping over discrete single cavity modes allows long laser coherence length even under dynamic very high speed tuning conditions. A ramp drive to the laser is used to linearize laser frequency tuning. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical signal from the reference arm and the sample arm for generating depth profiles and images of the sample.

Description:
RELATED APPLICATIONS 
       [0001]    This application claims the benefit under 35 USC 119(e) of U.S. Provisional Application No. 60/968,185, filed on Aug. 27, 2007. 
         [0002]    This application is related to U.S. application No. ______ filed on an even date herewith, entitled Linearized Swept Laser Source for Optical Coherence Analysis System, now U.S. Patent Publication No. ______, which is incorporated herein by reference in its entirety. 
     
    
     BACKGROUND OF THE INVENTION 
       [0003]    Optical coherence analysis relies on the use of the interference phenomena between a reference wave and an experimental wave or between two parts of an experimental wave to measure distances and thicknesses, and calculate indices of refraction of a sample. Optical Coherence Tomography (OCT) is one example technology that is used to perform usually high-resolution cross sectional imaging that can provide images of biological tissue structure, for example, on the microscopic scales in real time. Optical waves are sent through an object and a computer produces images of cross sections of the object by using information on how the waves are changed. 
         [0004]    The original OCT imaging technique, the time-domain OCT (TD-OCT) uses a movable reference mirror in a Michelson interferometer arrangement. Another type of optical coherence analysis is termed Fourier domain OCT (FD-OCT). Other terms are time encoded Frequency Domain OCT and swept source OCT. These techniques use either a wavelength swept source and a single detector, sometimes referred to as time-encoded FD-OCT or TEFD-OCT, or a broadband source and spectrally resolving detector system, sometimes referred to spectrum-encoded FD-OCT or SEFD-OCT. FD-OCT has advantages over time domain OCT (TD-OCT) in speed and signal-to-noise ratio (SNR). 
         [0005]    TEFD-OCT has advantages over SEFD-OCT in some respects. The spectral components are not encoded by spatial separation, but they are encoded in time. The spectrum is either filtered or generated in successive frequency steps and reconstructed before Fourier-transformation. Using the frequency scanning light source (i.e. wavelength tuned laser) the optical configuration becomes less complex but the critical performance characteristics now reside in the wavelength tuned laser. 
       SUMMARY OF THE INVENTION 
       [0006]    Frequency swept laser source for TEFD-OCT imaging requires tuning at very high repetition rates, in the tens of kilohertz, for fast real-time image frame acquisition with a sufficiently large image pixel count. At the same time, long coherence length of the source is required for large imaging depth range. Simultaneous high speed tuning while maintaining long coherence length is difficult to achieve in conventional tunable lasers, such as conventional external cavity semiconductor tunable lasers. 
         [0007]    Long laser coherence length requires narrow spectral linewidth operation and therefore demands a narrow bandwidth tunable filter for the laser. Fast tuning of a narrow filter implies laser light makes very few roundtrips inside the laser cavity as the filter shifts its center frequency by its width. Few roundtrips imply detrimental decrease of coherence length of the laser. We define dwell time as the number of roundtrips light makes inside the laser cavity while intracavity tunable filter tunes by its full width at half maximum. As the laser tuning speed is increased and the dwell time decreases to less than about 2, the laser coherence length degrades very rapidly and eventually the laser power turns off completely. One solution to this problem is the frequency domain modelocked laser (FDML), where light in a kilometer long fiber cavity is repetitively filtered by the tunable filter on multiple round trips in the cavity, such that long coherence length is maintained even at high tuning speeds. Such a laser, however, is bulky, has complications related to using very long fiber, and has a number of other limitations. 
         [0008]    Dwell time of a tunable laser at high tuning speed can be increased by using a short laser cavity length with a correspondingly small cavity roundtrip time. Such a short required cavity length, e.g. 10 to 30 millimeters (mm), is typically difficult to achieve with conventional external cavity semiconductor lasers. Using micro-electro-mechanical system (MEMS) tunable filters and optical micro-bench packaging allows such compact tunable lasers, however. 
         [0009]    Furthermore, as the cavity length gets smaller, cavity mode spacing gets larger, so that fewer modes remain lasing under the narrow tunable filter spectral envelope, eventually leaving just a single lasing mode. Conventional thinking has assumed that a continuously tuned laser mode or a group of modes is required for OCT imaging. However, since OCT data is read at discrete time intervals anyway, a laser tuned over a discrete set of individual wavelengths should be also suitable for OCT imaging. Such a discretely tuned single mode laser can have a short laser cavity and thus capable of operating at very high speeds with dwell times sufficiently high for maintaining the long required dynamic coherence length. 
         [0010]    The present invention concerns a wavelength tuned laser for an optical coherence analysis system. The laser hops between single discrete modes of the laser cavity. The laser can be tuned at very high scanning speeds while maintaining long coherence length. Further, laser frequency tuning with time can be linearized with a high utilization duty cycle. 
         [0011]    In general, according to one aspect, the invention features an optical coherence analysis system. This system comprises a swept laser source that generates an optical signal that is tuned over a spectral scan band at discrete wavelengths associated with longitudinal modes of the swept laser source. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical interference signal from the reference arm and the sample arm. 
         [0012]    In the preferred embodiment, the swept laser source comprises: a laser cavity defining the longitudinal modes, a semiconductor gain medium in the laser cavity, and a tuning element for the laser cavity. A phase compensation semiconductor medium is provided in the laser cavity for compensating for dispersion effects over the spectral scan band in some examples. 
         [0013]    The swept laser source comprises a tunable pass band filter that restricts the swept laser source to lasing at the discrete selected longitudinal modes. The tuning element comprises a Fabry-Perot tunable filter in the preferred embodiment, which is preferably a MEMS device. 
         [0014]    In the typical implementation, the system further comprises an image processing system for controlling the swept laser source and constructing an image from a response of the detector system. A trigger system is used for monitoring the swept laser source and signaling the image processing system to sample the response of the signal/reference detector system. 
         [0015]    In general, according to another aspect, the invention features an optical coherence analysis method, which comprises generating an optical signal that is tuned over a spectral scan band at discrete wavelengths. The optical signal is divided between a reference arm leading to a reference reflector and a sample arm leading to a sample. The signals from the reference arm and the sample arm are then optically interfered and detected. 
         [0016]    The above and other features of the invention including various novel details of construction and combinations of parts, and other advantages, will now be more particularly described with reference to the accompanying drawings and pointed out in the claims. It will be understood that the particular method and device embodying the invention are shown by way of illustration and not as a limitation of the invention. The principles and features of this invention may be employed in various and numerous embodiments without departing from the scope of the invention. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0017]    In the accompanying drawings, reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale; emphasis has instead been placed upon illustrating the principles of the invention. Of the drawings: 
           [0018]      FIG. 1  is a schematic block diagram of an optical coherence analysis system to which the invention is applicable; 
           [0019]      FIG. 2  is a schematic diagram of a single longitudinal mode hopping tunable laser for the optical coherence analysis system, according to a first embodiment of the present invention; 
           [0020]      FIG. 3  is a spectral plot illustrating the relationship between the tunable signal emission from the mode hopping laser, the laser&#39;s cavity modes, scan band, and intracavity filter passband; 
           [0021]      FIG. 4  is a schematic diagram of a single longitudinal mode hopping tunable laser for the optical coherence analysis system with phase compensation, according to a second embodiment of the present invention; 
           [0022]      FIG. 5  is a schematic diagram of a single longitudinal mode hopping tunable laser for the optical coherence analysis system using an single angle facet (SAF) semiconductor optical amplifier (SOA) chip, according to a third embodiment of the present invention; 
           [0023]      FIG. 6  is a schematic diagram of a single longitudinal mode hopping tunable laser for the optical coherence analysis system taking the tunable optical signal directly from the SOA, according to a fourth embodiment of the present invention; 
           [0024]      FIG. 7  is a plot of optical frequency as a function of scan period showing the inventive saw-toothed tuning ramp compared with a convention sinusoid tuning drive; and 
           [0025]      FIG. 8  is a flow diagram illustrating process for optical coherence analysis. 
       
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
       [0026]      FIG. 1  shows an optical coherence analysis system to which the present invention is applicable. 
         [0027]    In more detail, the illustrated system is a time encoded Fourier domain optical coherence tomography system (TEFD-OCT). As such it comprises a tunable narrowband light source. Specifically, a tunable semiconductor diode laser system  100  is used. The light from the tunable laser  100  is output on a fiber  125  to a tap  50 . A tap  50  takes a portion of the tunable signal from the tunable laser  100  and directs it to a wavelength or frequency reference system. Specifically, the tap  50  is coupled to a reference filter  52  that applies a known spectral function against the tunable signal. A reference detector  54  detects the tunable signal as it is filtered by the reference filter  52 . In one example, the reference filter  52  comprises a fixed etalon providing a series of transmission peaks spaced at known wavelengths. 
         [0028]    The light that is not diverted by the tap  50  is provided to a circulator  56 . This directs the light from the tunable laser  100  to a coupler  60 . The tunable signal is divided by the coupler  60  into a reference arm and a sample arm of the system. Specifically, the optical fiber of the reference arm terminates at the fiber endface  62 . The light exiting from the reference arm fiber endface  62  is collimated by a lens  64  and then reflected on a mirror  66  to return back to the coupler  60 . 
         [0029]    The external mirror  66  has an adjustable fiber to mirror distance. This distance determines the depth range being imaged, i.e. the position in the sample of the zero path length difference between the reference and the sample arms. The distance is adjusted for different sampling catheters and/or imaged samples. 
         [0030]    The fiber on the sample arm terminates at the sample arm fiber endface  70 . The light exiting from the fiber endface  70  is focused by a lens  72  onto the sample  75 . The fiber endface  70  and the lens  72  are controlled by an x-y-z scanner  68 . Specifically, the x-y-z scanner  68  scans the focused beam from the fiber endface  70  relative to the sample  75  while collecting the spectral response from the sample  75 . The light reflected back into the fiber endface  70  is returned to the coupler  60  which then combines the signals from the reference and sample arms. Light then returns to a first detector  58  via circulator  56  and to a second detector  62 . 
         [0031]    In examples, the x-y-z scanning is implemented by moving the lens  72  and endface  70  using a three dimensional positioner. In other examples, the x-y-z scanning is implemented by moving the sample  75  relative to the lens  72  and endface  70 . In still other examples, the scanning is implemented by rotating and laterally moving the lens  72 /endface  70 . 
         [0032]    The first detector  58  and the second detector  62  function in a balanced detector scheme. Specifically, their electrical responses are combined in a differential amplifier  86  and then sampled in a current embodiment. 
         [0033]    In one implementation, an analog to digital converter system  82  of a digital signal processor (DSP)  80  is used to sample the output from the differential amplifier  86 . 
         [0034]    The analog to digital detection system  82 , and usually a second converter, is used to sample the output from the reference detector  54 . As a result, the DSP  80  is able to determine the instantaneous wavelength or frequency of the tunable laser  100  as it scans over the scan band. 
         [0035]    In one embodiment, the output of the tunable laser is also provided to a direct trigger circuit  75  to provide the sampling trigger to the analog to digital converter system  82 . Specifically, the trigger  75  detects the instantaneous amplitude of the tunable laser  100 . When the amplitude jumps high as the tunable laser scans and discretely hops between the modes of the laser, the trigger circuit  75  generates a trigger signal that the analog to digital converter system  82  of the digital signal processor  80  uses to trigger and thus sample the output of the differential amplifier  86 . In this case such direct laser trigger signal  75  is used instead of the reference detector  54  trigger signal. 
         [0036]    Once a complete data set has been collected from the surface of the sample  75  by the operation of the scanner  68  and the spectral response at each one of these points is generated from the tuning of the tunable laser  100 , the digital signal processor  80  performs a Fourier transform on the data in order to reconstruct the image and perform a 2D or 3D tomographic reconstruction of the sample  75 . This information is generated by the digital signal processor  80  is then displayed on a video monitor  84 . 
         [0037]      FIG. 2  shows the tunable semiconductor laser  100  according to a first embodiment of the invention. 
         [0038]    In more detail, the tunable laser  100  comprises a semiconductor gain chip  110  that is paired with a microelectromechanical (MEMS) angled reflective Fabry-Perot tunable filter  112  to create external cavity tunable laser (ECL). 
         [0039]    The semiconductor optical amplifier (SOA) chip  110  is located within a laser cavity  105 . In the current embodiment, both facets of the SOA chip are angled and anti-reflection (AR) coated, providing parallel beams from the two facets. 
         [0040]    Specifically, each end facet of the SOA  110  has associated lenses  114 ,  116  that are used to couple the light exiting from either facet of the SOA  110 . The first lens  114  couples the light between the back facet of the SOA  110  and a mirror  118 . Light exiting out the front facet of the SOA  110  is coupled by a second lens  116  to the reflective Fabry-Perot tunable filter  112 . 
         [0041]    The angled reflective Fabry-Perot filter is a multi-spatial-mode tunable filter that provides angular dependent reflective spectral response back into the laser cavity  105 . This phenomenon is discussed in more detail in incorporated US20060215713A1. 
         [0042]    In one specific example, the filter  112  is a curved-flat Fabry-Perot tunable filter that supports multiple spatial modes. 
         [0043]    The light transmitted by the tunable filter  112  is coupled through to a third lens  122 . This focuses the light down into the endface  124  of an output optical fiber  125 , such as single mode fiber, which can also be polarization controlling, such as polarization maintaining (PM), fiber. 
         [0044]    The single mode fiber  125  ultimately transports the tunable signal to the coupler  60  and then to each of the reference and sample arms of the optical coherence analysis system  100 , see  FIG. 1 .  
         [0045]    In one embodiment, the drive current to the semiconductor optical amplifier  110  is controlled by the digital signal processor  80 . Specifically, in one implementation the drive current is controlled to stabilize the power output of the laser  100 . Further, in the preferred embodiment, the signal processor  80  either is implemented to function as a ramp generator or a separate ramp generator circuit  120  is provided, which is triggered by the DSP  80 . The ramp generator  120  provides a saw-toothed tuning voltage curve to the tunable filter  112  to thereby provide substantially linear frequency tuning with time over the scan band, which also maximizes the tuning performance of the tunable laser  100 . 
         [0046]    In the preferred embodiment the tunable laser  100  is implemented on an optical bench  107 , which is installed in a hermetic package  106 . Specifically, this is a micro-optical bench to provide a relatively short laser cavity  105 .  
         [0047]      FIG. 3  is an exemplary spectral plot illustrating of the relationship between the scan band  310 , longitudinal cavity modes  152 , the passband  154  for the tunable filter  112 , and the laser emission/tunable signal  150 .  
         [0048]    The scan band  310  for the tunable laser  100  extends over a wavelength range. The passband  154  of the tunable filter  112  is then scanned over the band  310 . Its passband is such that it only selects no more than one of the cavity modes  152  of the laser cavity  105 . Thus, at points when the passband is directly between cavity modes, spectrally, it is possible that no cavity modes are lasing. However, when the passband  154  aligns with a given cavity mode then the output tunable signal  150  is produced. In this way, the laser system  100  functions as a mode-hopping laser system that only produces an optical signal at the discrete wavelengths of the cavity modes  152 .  
         [0049]      FIG. 4  shows a second embodiment of the mode hopping tunable laser  100 . This includes a second semiconductor chip section  111  that functions as an intra cavity phase or dispersion compensator, which is integral with the semiconductor gain medium in a preferred embodiment. Specifically, there is a certain amount of dispersion during scanning, which implies variation of cavity mode frequency spacing. The cavity  105  is not all air; there is refractive index dispersion in the laser chip, lenses, optical coatings. Also, laser threshold changes over the tuning range. Thus, there will typically be higher carrier density inside the gain chip  110 , when it is tuned to the edges of the spectrum. This increased carrier density decreases the chip&#39;s refractive index and thereby causes a dispersion-like effect. 
         [0050]    The phase compensator  111  controls its refractive index and thus the optical length of the cavity as compensation. 
         [0051]    In other embodiments, the compensator includes an electro-optic medium. 
         [0052]    In other embodiments, signal processing by the DSP  80  is used to compensate for dispersion in the case of the mode-hopping laser. This involves measuring the laser&#39;s tuning dispersion. This dispersion relates to the variation in the optical frequency spacing between modes across the scan band. The collected data is then resampled onto an equally spaced frequency grid before doing the FFT to make the image. 
         [0053]      FIG. 5  shows a third embodiment of the mode hopping tunable laser  100 . This uses a reflective SOA or single angled facet (SAF) chip  110 ′. Specifically, the back normal facet  512  of the semiconductor amplifier  110 ′ is reflective to define one end of the laser cavity  105 . On the front angled non-reflective facet, a series of three lenses  116 - 1 ,  116 - 2 ,  116 - 3  is used to collimate the output of the semiconductor amplifier and relay it to the tunable filter  112 , thereby yielding the laser cavity with the desired length. Also in one implementation, light output through fiber  510  is taken, alternatively or in addition to output fiber  125 , through the back facet  512  of the reflective optical amplifier SAF  110 ′. This is used to provide an alternative output of the tunable laser or a second laser output to serve as a possible input to the trigger circuit  75 , see  FIG. 1 . 
         [0054]    In a variant design for longer laser cavities, the reflective SOA  110 ′ is replaced with an SOA having antireflection (AR) coated front and rear facets. Further, the facet  540  of the optical fiber  510  is AR coated. This extends the laser cavity  105  into the fiber  510 . Thus, with a reflective coated end  530  of the optical fiber, the length of the cavity is made longer to include a portion of the cavity in the fiber  510 .  
         [0055]      FIG. 6  shows a fourth embodiment in which the tunable filter  112  forms the one end of the laser cavity  105 . The other end of the laser cavity is formed by a mirror  124 ′ formed or deposited on the endface of output optical fiber  125 . In preferred embodiment, the mirror is a dielectric multi-layer stack mirror. Further, the fiber  125  preferably has a mode expanded core or an integral mode expander/collimator, such as a fused graded index lens, at the endface/mirror  124 ′ so that the mode size of the fiber output matches the beam size produced by lens  114  from the output of SOA  110 . 
         [0056]    This embodiment provides higher levels of output power since the output light does not need to pass through the tunable filter  112  and suffer corresponding insertion loss. Also, the beam profile is less distorted, yielding good power coupling. On the other hand, broadband amplified spontaneous emissions from the semiconductor amplifier  110  are not filtered out, as they are when output is taken through the filter  112 . 
       Mode Hopping Laser Specifications  
       [0057]    The laser cavity  105  is preferably only about 10-30 millimeters (mm) long, in air. This provides roundtrip times that are on the order 0.07-0.20 nanoseconds (nsec). This short cavity provides for good dynamic laser coherence length upon fast sweep tuning: relatively long coherence length is largely preserved upon fast tuning because of the relatively short cavity.  
         [0058]    The passband of the tunable filter  112  is selected to be relatively spectrally narrow in relation to the spectral longitudinal cavity mode spacing of the cavity  105 . Specifically, the filter is narrow to ensure only a few, and preferably never more than one, longitudinal mode of the cavity can lase during the scanning of the filter  112 . In one example, the passband of the filter  112  is less than 10 giga-Hertz (GHz) wide and is preferably about 5.0 GHz wide, tuning over 100 nanometer scan band near 1300 nm wavelength at 45 kilo-Hertz (kHz) repetition rate. Thus, the filter  112  tunes by one bandwidth in 2.0 nanosecond (nsec). This yields dwell times of 10-57 for 10-30 mm cavities, where dwell time is the number of roundtrips light makes inside laser cavity while the filter tunes by its full width at half maximum. Large dwell times imply static laser coherence length is well preserved under dynamic tuning conditions; for dwell times less than about 2, dynamic laser coherence length decreases rapidly. 
         [0059]    First single-mode laser: 
         [0060]    Filter  112 , bandwidth 6-8 GHz. 
         [0061]    Length of laser cavity  105 : ˜17.5 mm, Mode Spacing ˜8.6 GHz. 
         [0062]    Lorentzian filter transmission at side-mode: 0.11-0.20. Good single mode operation with low, &gt;30 dB, sidemodes. 
         [0063]    Second single-mode laser: 
         [0064]    Filter  112  bandwidth: 9-12 GHz. 
         [0065]    Length of laser cavity  105 : 21 mm, Mode Spacing ˜7.0 GHz. 
         [0066]    Lorentzian filter transmission at side-mode: 0.29-0.42. 
         [0067]    side-mode suppression ration (SMSR) only ˜10-15 dB. 
         [0068]      FIG. 7  shows the conventional sinusoidal filter tuning drive. As a result, only a small portion of the total scan period has a near linear tuning curve (see sinusoid scan utilization time period  710 ). This sinusoidal drive signal is necessitated by the relative high mass spectral tuning elements used in convention ECL devices, which requires driving such tunable filters sinusoidally in time near their resonant frequency. MEMS tunable filters, preferably used in the inventive lasers, have high resonance frequencies and their frequency tuning with time can be linearized for repetition frequencies of 50-100 kHz and higher. 
         [0069]    According to the present invention, the ramp generator  120  produces a sawtoothed drive signal  714  to provide a linearized sweep that extends over 50% and preferably greater than 80% of the scan period  310 , providing much higher duty cycles of 50-80% and greater. 
         [0070]      FIG. 8  illustrates the process performed by the optical coherence analysis system. Specifically, in step  1010  the laser is scanned through the discrete wavelengths of the spectral scan band. In step  1012 , the detector system response is stored as a function of wavelength by the digital signal processor  80  in one example. The data are then reassembled on to an equally spaced frequency grid in step  114 . This is required if the discrete laser scan frequencies do not have the same spectral separation. 
         [0071]    Finally, in step  1016  an inverse Fourier transform is applied to the data in order to reconstruct the image of the sample. 
         [0072]    While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.